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MA29791B1 - Composes therapeutiques. - Google Patents

Composes therapeutiques.

Info

Publication number
MA29791B1
MA29791B1 MA30764A MA30764A MA29791B1 MA 29791 B1 MA29791 B1 MA 29791B1 MA 30764 A MA30764 A MA 30764A MA 30764 A MA30764 A MA 30764A MA 29791 B1 MA29791 B1 MA 29791B1
Authority
MA
Morocco
Prior art keywords
therapeutic compounds
compounds
solvates
processes
formula
Prior art date
Application number
MA30764A
Other languages
English (en)
Inventor
Brian Douglas Patterson
Sylvie Kim Sakata
Mitchell David Nambu
Leena Bharat Kumar Patel
John Howard Tatlock
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA29791B1 publication Critical patent/MA29791B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composés thérapeutiques La présente invention propose des composés de formule (I) ou leurs sels ou produits de solvatation pharmaceutiquement acceptables, des procédés pour leur préparation, des méthodes pour leur utilisation, et des compositions pharmaceutiques les contenant.
MA30764A 2005-09-23 2008-03-19 Composes therapeutiques. MA29791B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72015105P 2005-09-23 2005-09-23
US72311505P 2005-10-03 2005-10-03
US72546905P 2005-10-11 2005-10-11
US76225606P 2006-01-25 2006-01-25
US82166406P 2006-08-07 2006-08-07

Publications (1)

Publication Number Publication Date
MA29791B1 true MA29791B1 (fr) 2008-09-01

Family

ID=37889174

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30764A MA29791B1 (fr) 2005-09-23 2008-03-19 Composes therapeutiques.

Country Status (29)

Country Link
US (1) US7868026B2 (fr)
EP (1) EP1937639B1 (fr)
JP (1) JP4336738B2 (fr)
KR (1) KR100975448B1 (fr)
CN (1) CN101287708B (fr)
AT (1) ATE459603T1 (fr)
AU (1) AU2006293605B2 (fr)
BR (1) BRPI0616156A2 (fr)
CA (1) CA2621805C (fr)
CY (1) CY1110010T1 (fr)
DE (1) DE602006012713D1 (fr)
DK (1) DK1937639T3 (fr)
EA (1) EA014329B1 (fr)
EC (1) ECSP088296A (fr)
ES (1) ES2340200T3 (fr)
GE (1) GEP20115230B (fr)
HK (1) HK1120506A1 (fr)
HR (1) HRP20100272T2 (fr)
IL (1) IL189666A (fr)
MA (1) MA29791B1 (fr)
MY (1) MY143391A (fr)
NO (1) NO20081844L (fr)
NZ (1) NZ566136A (fr)
PL (1) PL1937639T3 (fr)
PT (1) PT1937639E (fr)
RS (2) RS51349B (fr)
SI (1) SI1937639T1 (fr)
TN (1) TNSN08139A1 (fr)
WO (1) WO2007034312A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090034958A (ko) * 2006-07-05 2009-04-08 화이자 프로덕츠 인크. 시토크롬 ｐ４５０ 억제제로서의 피라졸 유도체
CA2673586A1 (fr) * 2006-12-26 2008-07-24 Amgen Inc. N-cyclohexyl benzamides et benzene acetamides utilises comme inhibiteurs de 11-beta-hydroxysteroides deshydrogenases
EP2126574B1 (fr) 2007-03-08 2015-12-23 The Board of Trustees of the Leland Stanford Junior University Modulateurs de l'aldéhyde deshydrogènase-2 mitochondrial, et leurs procédés d'utilisation
EP2207540B1 (fr) * 2007-10-04 2014-02-26 F. Hoffmann-La Roche AG Dérivés de cyclopropyl aryl amides et leurs utilisations
ES2477552T3 (es) 2008-09-08 2014-07-17 The Board Of Trustees Of The Leland Stanford Junior University Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos
WO2010062308A1 (fr) * 2008-10-28 2010-06-03 The Board Of Trustees Of The Leland Stanford Junior University Modulateurs d’aldéhyde déshydrogénase et procédés d’utilisation de ceux-ci
CA2747419C (fr) 2009-01-12 2014-07-08 Icagen, Inc. Derives sulfonamides
KR20140071518A (ko) * 2009-05-01 2014-06-12 라퀄리아 파마 인코포레이티드 Ｔｒｐｍ8 길항제로서의 설파모일 벤조산 유도체
JP5872552B2 (ja) 2010-07-09 2016-03-01 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 化学化合物
WO2012149106A1 (fr) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions et procédés d'augmentation de la prolifération de cellules souches salivaires adultes
CN104540813A (zh) * 2012-06-27 2015-04-22 默沙东公司 磺酰胺衍生物以及使用它们用于改善药物的药物动力学的方法
WO2014000178A1 (fr) 2012-06-27 2014-01-03 Merck Sharp & Dohme Corp. Dérivés de sulfamide et leurs méthodes d'utilisation permettant d'améliorer la pharmacocinétique d'un médicament
WO2014160185A2 (fr) 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Modulateurs de l'aldéhyde déshydrogénase-2 mitochondriale et leurs procédés d'utilisation
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
WO2014194519A1 (fr) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Dérivés imidazole et leurs procédés d'utilisation pour l'amélioration des propriétés pharmacocinétiques d'un médicament
WO2015070366A1 (fr) 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Dérivés d'imidazole et de triazole liés à aryle et leurs procédés d'utilisation pour améliorer la pharmacocinétique d'un médicament
WO2015070367A1 (fr) 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Dérivés d'imidazole et de triazole liés à la pipéridine ou la pipérazine et leurs procédés d'utilisation pour améliorer la pharmacocinétique d'un médicament
AU2015238537B2 (en) 2014-03-26 2019-08-01 F. Hoffmann-La Roche Ag Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
WO2016101118A1 (fr) * 2014-12-23 2016-06-30 Merck Sharp & Dohme Corp. Antagonistes des récepteurs d'orexine de type amidoéthylazole
CA2992889A1 (fr) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Derives de phenoxymethyle
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー Ａｔｘインヒビターとしての新規二環式化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7169763B2 (en) * 2002-02-22 2007-01-30 Oliver Yoa-Pu Hu Cytochrome P450 3A inhibitors and enhancers

Also Published As

Publication number Publication date
CN101287708B (zh) 2012-02-29
CY1110010T1 (el) 2015-01-14
NO20081844L (no) 2008-05-29
ES2340200T3 (es) 2010-05-31
PT1937639E (pt) 2010-04-23
AU2006293605B2 (en) 2011-05-19
SI1937639T1 (sl) 2010-07-30
JP4336738B2 (ja) 2009-09-30
RS20080118A (en) 2009-05-06
HRP20100272T2 (hr) 2010-07-31
WO2007034312A2 (fr) 2007-03-29
EP1937639B1 (fr) 2010-03-03
EP1937639A2 (fr) 2008-07-02
WO2007034312A3 (fr) 2007-08-23
GEP20115230B (en) 2011-06-10
CN101287708A (zh) 2008-10-15
ECSP088296A (es) 2008-06-30
US7868026B2 (en) 2011-01-11
DK1937639T3 (da) 2010-05-10
MY143391A (en) 2011-05-13
EA014329B1 (ru) 2010-10-29
AU2006293605A1 (en) 2007-03-29
NZ566136A (en) 2010-04-30
ATE459603T1 (de) 2010-03-15
RS51349B (en) 2011-02-28
JP2009508931A (ja) 2009-03-05
KR20080038431A (ko) 2008-05-06
US20070167497A1 (en) 2007-07-19
PL1937639T3 (pl) 2010-07-30
TNSN08139A1 (fr) 2009-07-14
KR100975448B1 (ko) 2010-08-11
IL189666A (en) 2011-12-29
IL189666A0 (en) 2008-08-07
BRPI0616156A2 (pt) 2011-06-07
CA2621805C (fr) 2011-05-10
EA200800542A1 (ru) 2008-08-29
DE602006012713D1 (de) 2010-04-15
HK1120506A1 (en) 2009-04-03
CA2621805A1 (fr) 2007-03-29
HRP20100272T1 (en) 2010-06-30

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