MA27490A1 - Formulation d'ibuprofene sodique. - Google Patents
Formulation d'ibuprofene sodique.Info
- Publication number
- MA27490A1 MA27490A1 MA28268A MA28268A MA27490A1 MA 27490 A1 MA27490 A1 MA 27490A1 MA 28268 A MA28268 A MA 28268A MA 28268 A MA28268 A MA 28268A MA 27490 A1 MA27490 A1 MA 27490A1
- Authority
- MA
- Morocco
- Prior art keywords
- weight
- sodium hydrate
- tablet
- ibuprofen
- coating
- Prior art date
Links
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229910052708 sodium Inorganic materials 0.000 title 1
- 239000011734 sodium Substances 0.000 title 1
- VTGPMVCGAVZLQI-UHFFFAOYSA-M sodium;2-[4-(2-methylpropyl)phenyl]propanoate;dihydrate Chemical compound O.O.[Na+].CC(C)CC1=CC=C(C(C)C([O-])=O)C=C1 VTGPMVCGAVZLQI-UHFFFAOYSA-M 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000007888 film coating Substances 0.000 abstract 1
- 238000009501 film coating Methods 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Comprimé non effervescent d'ibuprofène. comprenant un comprimé nu et, si on le souhaite, une dragéification ou un pelliculage, dans lequel le comprimé nu se compose de 50 à 100% en poids d'hydrate d'ibuprofène sodique et de 50 à 0% en poids d'adjuvant, sur la base du poids du comprimé nu. et ne contient ni lubrifiant ni agent de délitement, l'hydrate d'ibuprofène sodique ayant une teneur en eau allant de 8 à 16%, de préference de 11 à 16% en poids, qui possède une dureté suffisante, qui est d'une taille relativement petite et mène à une augmentation particulièrement rapide des concentrations sanguines et, par conséquence, a un début accéléré de l'effet analgésique. Contrairement à l'opinion reçue, l'hydrate d'ibuprofène sodique ayant une teneur en eau appropriée est suffisamment compressible.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH01703/02A CH693586A8 (de) | 2002-10-14 | 2002-10-14 | Darreichungsform von Ibuprofen-Natrium. |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27490A1 true MA27490A1 (fr) | 2005-08-01 |
Family
ID=28796671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28268A MA27490A1 (fr) | 2002-10-14 | 2005-05-09 | Formulation d'ibuprofene sodique. |
Country Status (32)
Country | Link |
---|---|
US (1) | US20040102522A1 (fr) |
EP (1) | EP1410793B1 (fr) |
JP (1) | JP4608316B2 (fr) |
KR (1) | KR101046894B1 (fr) |
CN (1) | CN100592909C (fr) |
AR (1) | AR041428A1 (fr) |
AT (1) | ATE309789T1 (fr) |
AU (1) | AU2003266094B2 (fr) |
BR (1) | BRPI0315248B1 (fr) |
CA (1) | CA2500987A1 (fr) |
CH (1) | CH693586A8 (fr) |
CO (1) | CO5700709A2 (fr) |
DE (1) | DE50301661D1 (fr) |
DK (1) | DK1410793T3 (fr) |
EA (1) | EA007914B1 (fr) |
EC (1) | ECSP055793A (fr) |
ES (1) | ES2249702T3 (fr) |
HR (1) | HRP20050429A2 (fr) |
IL (1) | IL167357A (fr) |
MA (1) | MA27490A1 (fr) |
MX (1) | MXPA05003592A (fr) |
MY (1) | MY132858A (fr) |
NO (1) | NO20052343L (fr) |
NZ (1) | NZ539405A (fr) |
PA (1) | PA8586101A1 (fr) |
PE (1) | PE20040417A1 (fr) |
PL (1) | PL376177A1 (fr) |
SI (1) | SI1410793T1 (fr) |
TW (1) | TWI262800B (fr) |
UA (1) | UA86751C2 (fr) |
WO (1) | WO2004035024A1 (fr) |
ZA (1) | ZA200502925B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3920358A1 (de) * | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US6705028B2 (en) * | 2001-09-12 | 2004-03-16 | Honda Giken Kogyo Kabushiki Kaisha | Self-propelled snowplow vehicle |
US20050176809A1 (en) * | 2004-02-05 | 2005-08-11 | Rodlen Laboratories, Inc. | Method and compositions for treatment of painful disorders |
PL1799195T3 (pl) * | 2004-08-12 | 2016-09-30 | Granulki zawierające paracetamol, nlpz i alkohol cukrowy wytwarzane przez wytłaczanie ze stopionego materiału | |
US20070077297A1 (en) | 2004-09-30 | 2007-04-05 | Scolr Pharma, Inc. | Modified release ibuprofen dosage form |
WO2006093353A1 (fr) | 2005-03-03 | 2006-09-08 | Takeda Pharmaceutical Company Limited | Composition a liberation controlee |
WO2006100281A2 (fr) | 2005-03-22 | 2006-09-28 | Losan Pharma Gmbh | Ibuprofene solubilise |
EP1800667A1 (fr) | 2005-12-23 | 2007-06-27 | Losan Pharma GmbH | Granulate d'ibuprofen solubilisé rapidement |
DE102006029233A1 (de) * | 2006-06-26 | 2007-12-27 | Liedtke, Rainer K., Dr. | Formulierungen zur Verbesserung der Verträglichkeit nichtsteroidaler Antiphlogistika |
CL2007002425A1 (es) | 2006-08-22 | 2008-06-27 | Albermarle Corp | Procedimiento de preparacion controlado de sal sodica de ibuprofeno de tamano de particula mediano; y dichas particulas de sal sodica. |
FI20080348A0 (fi) * | 2008-02-15 | 2008-05-09 | Atacama Labs Oy | Uudenlainen farmaseuttinen formulaatio |
US7749537B2 (en) * | 2006-12-04 | 2010-07-06 | Scolr Pharma, Inc. | Method of forming a tablet |
US9629809B2 (en) | 2008-07-21 | 2017-04-25 | Si Group, Inc. | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
US9629806B2 (en) | 2008-07-21 | 2017-04-25 | Si Group, Inc. | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
WO2011001228A1 (fr) * | 2008-08-14 | 2011-01-06 | Shasun Chemicals And Drugs Limited | Sels dacide arylalkylcarboxylique, procédé pour leur préparation et formes galéniques |
UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
SG10201509312UA (en) | 2009-06-22 | 2015-12-30 | Wyeth Llc | Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen |
AU2015264861C1 (en) * | 2009-06-22 | 2017-11-16 | Pf Consumer Healthcare 1 Llc | Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen |
AU2014200704C1 (en) * | 2009-06-22 | 2018-12-06 | Pf Consumer Healthcare 1 Llc | Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen |
FR2997856B1 (fr) * | 2012-11-14 | 2015-04-24 | Pf Medicament | Pastille medicamenteuse a base d'ibuprofene sodique dihydrate |
EP2965746B1 (fr) | 2014-07-10 | 2019-03-13 | Santa Farma Ilaç Sanayi A.S. | Composition pharmaceutique orale comprenant de l'ibuprofène, du dihydrate de sodium d'ibuprofène, de l'hydrochlorure de pseudoéphédrine et du maléate de chlorophéniramine |
US20180078516A1 (en) * | 2016-09-19 | 2018-03-22 | Innovazone Labs LLC | Pharmaceutical Composition of Ibuprofen Sodium for Oral Administration |
CN113893227B (zh) * | 2021-11-18 | 2023-04-14 | 山东则正医药技术有限公司 | 布洛芬片的制备原料、制备方法和布洛芬片 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5104648A (en) * | 1989-02-02 | 1992-04-14 | Mallinckrodt Specialty Chemicals Company | High ibuprofen content granulations |
GB8920693D0 (en) * | 1989-09-13 | 1989-10-25 | Nicholas Kiwi Pty Ltd | Non-effervescent ibuprofen compositions |
CA2061520C (fr) * | 1991-03-27 | 2003-04-22 | Lawrence J. Daher | Systeme de delivrance accelerant l'effet et accroissant la puissance |
GB9224021D0 (en) * | 1992-11-16 | 1993-01-06 | Boots Co Plc | Effervescent compositions |
US6083430A (en) * | 1994-10-28 | 2000-07-04 | Fuisz Technologies Ltd. | Method of preparing a dosage unit by direct tableting and product therefrom |
GB9603699D0 (en) * | 1996-02-21 | 1996-04-17 | Boots Co Plc | Therapeutic composition |
IT1301966B1 (it) * | 1998-07-30 | 2000-07-20 | Zambon Spa | Composizioni farmaceutiche ad attivita' analgesica |
-
2002
- 2002-10-14 CH CH01703/02A patent/CH693586A8/de not_active IP Right Cessation
-
2003
- 2003-04-03 EP EP03405225A patent/EP1410793B1/fr not_active Expired - Lifetime
- 2003-04-03 DK DK03405225T patent/DK1410793T3/da active
- 2003-04-03 DE DE50301661T patent/DE50301661D1/de not_active Expired - Fee Related
- 2003-04-03 SI SI200330125T patent/SI1410793T1/sl unknown
- 2003-04-03 AT AT03405225T patent/ATE309789T1/de not_active IP Right Cessation
- 2003-04-03 ES ES03405225T patent/ES2249702T3/es not_active Expired - Lifetime
- 2003-09-10 UA UAA200504484A patent/UA86751C2/ru unknown
- 2003-09-22 TW TW092126096A patent/TWI262800B/zh active
- 2003-09-29 AR ARP030103544A patent/AR041428A1/es unknown
- 2003-09-30 MY MYPI20033728A patent/MY132858A/en unknown
- 2003-10-09 NZ NZ539405A patent/NZ539405A/en unknown
- 2003-10-09 AU AU2003266094A patent/AU2003266094B2/en not_active Expired - Fee Related
- 2003-10-09 BR BRPI0315248A patent/BRPI0315248B1/pt not_active IP Right Cessation
- 2003-10-09 KR KR1020057006414A patent/KR101046894B1/ko active IP Right Grant
- 2003-10-09 CN CN200380101345A patent/CN100592909C/zh not_active Expired - Fee Related
- 2003-10-09 EA EA200500649A patent/EA007914B1/ru not_active IP Right Cessation
- 2003-10-09 WO PCT/CH2003/000662 patent/WO2004035024A1/fr active Application Filing
- 2003-10-09 MX MXPA05003592A patent/MXPA05003592A/es active IP Right Grant
- 2003-10-09 JP JP2004543886A patent/JP4608316B2/ja not_active Expired - Fee Related
- 2003-10-09 CA CA002500987A patent/CA2500987A1/fr not_active Abandoned
- 2003-10-09 PL PL03376177A patent/PL376177A1/xx not_active Application Discontinuation
- 2003-10-10 PE PE2003001033A patent/PE20040417A1/es not_active Application Discontinuation
- 2003-10-13 PA PA20038586101A patent/PA8586101A1/es unknown
- 2003-10-14 US US10/683,283 patent/US20040102522A1/en not_active Abandoned
-
2005
- 2005-03-09 IL IL167357A patent/IL167357A/en not_active IP Right Cessation
- 2005-04-11 ZA ZA200502925A patent/ZA200502925B/en unknown
- 2005-05-09 MA MA28268A patent/MA27490A1/fr unknown
- 2005-05-10 CO CO05044513A patent/CO5700709A2/es not_active Application Discontinuation
- 2005-05-12 NO NO20052343A patent/NO20052343L/no not_active Application Discontinuation
- 2005-05-13 HR HR20050429A patent/HRP20050429A2/xx not_active Application Discontinuation
- 2005-05-13 EC EC2005005793A patent/ECSP055793A/es unknown
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