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MA21808A1 - Procede de production de derives de 2 - oxindole substitues en position 3 . - Google Patents

Procede de production de derives de 2 - oxindole substitues en position 3 .

Info

Publication number
MA21808A1
MA21808A1 MA22068A MA22068A MA21808A1 MA 21808 A1 MA21808 A1 MA 21808A1 MA 22068 A MA22068 A MA 22068A MA 22068 A MA22068 A MA 22068A MA 21808 A1 MA21808 A1 MA 21808A1
Authority
MA
Morocco
Prior art keywords
oxindole
substituted
producing derivatives
derivatives
producing
Prior art date
Application number
MA22068A
Other languages
English (en)
Inventor
Carl Joseph Godard
Gary Richard Schulte
Frederick Jacob Ehrgott
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA21808A1 publication Critical patent/MA21808A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
MA22068A 1989-04-18 1990-04-17 Procede de production de derives de 2 - oxindole substitues en position 3 . MA21808A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34011389A 1989-04-18 1989-04-18

Publications (1)

Publication Number Publication Date
MA21808A1 true MA21808A1 (fr) 1990-12-31

Family

ID=23331948

Family Applications (1)

Application Number Title Priority Date Filing Date
MA22068A MA21808A1 (fr) 1989-04-18 1990-04-17 Procede de production de derives de 2 - oxindole substitues en position 3 .

Country Status (33)

Country Link
US (4) US5047554A (fr)
EP (1) EP0393936B1 (fr)
JP (2) JP2506478B2 (fr)
KR (1) KR920006394B1 (fr)
CN (1) CN1022832C (fr)
AP (1) AP142A (fr)
AT (1) ATE118767T1 (fr)
AU (1) AU633767B2 (fr)
BG (1) BG60646B1 (fr)
CA (1) CA2014467C (fr)
CZ (1) CZ284340B6 (fr)
DD (1) DD293822A5 (fr)
DE (1) DE69017066T2 (fr)
DK (1) DK0393936T3 (fr)
EG (1) EG19122A (fr)
ES (1) ES2068334T3 (fr)
FI (1) FI106378B (fr)
GR (1) GR3015811T3 (fr)
HU (2) HUT58314A (fr)
IE (1) IE65091B1 (fr)
IL (3) IL110173A (fr)
IS (1) IS1636B (fr)
MA (1) MA21808A1 (fr)
MX (1) MX20359A (fr)
NO (1) NO176759C (fr)
NZ (1) NZ233320A (fr)
OA (1) OA09205A (fr)
PL (2) PL163941B1 (fr)
PT (1) PT93785B (fr)
RO (1) RO106402B1 (fr)
RU (2) RU2039042C1 (fr)
YU (1) YU47588B (fr)
ZA (1) ZA902871B (fr)

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HU208421B (en) * 1988-10-18 1993-10-28 Pfizer Process for producing starting materials for producing 3-acyl-2-oxindol-carboxamides ofantiphlogistic activity
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
TW438798B (en) * 1992-10-07 2001-06-07 Pfizer 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
CZ131695A3 (en) * 1992-11-23 1996-05-15 Pfizer Process for preparing 4-chloro-2-thiophenecarboxylic acid, intermediates for its preparation and process for preparing 5-fluoro-6-chloro-3-(4-chloro-2-thenoyl)-2-oxindole-1-carboxamide
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
JP2709530B2 (ja) * 1993-02-09 1998-02-04 ファイザー・インク． 抗炎症薬としてのオキシンドール１−［ｎ−（アルコキシカルボニル）］カルボキサミド類および１−（ｎ−カルボキサミド）カルボキサミド類
ES2076106B1 (es) * 1993-08-26 1996-06-16 Pfizer Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas
US5783664A (en) * 1993-09-17 1998-07-21 Smithkline Beecham Corporation Cytokine suppressive anit-inflammatory drug binding proteins
EP0679396A1 (fr) * 1994-03-02 1995-11-02 Pfizer Inc. Utilisation de dérivés oxindol-2-carboxamides-1,3-substitués pour la fabrication d'un médicament destiné au traiter des dommages du myocardes causés par une ischémie et les dommages du myocardes induits par les cytokines
CN1051452C (zh) * 1994-07-26 2000-04-19 中国医学科学院血液学研究所 3-取代芳基氧化吲哚类化合物的应用
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US6043379A (en) * 1997-04-04 2000-03-28 Pfizer Inc. Processes and intermediates for preparing 2-fluorothiophene derivatives
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PL211834B1 (pl) 2000-02-15 2012-06-29 Sugen Związki 2-indolinonowe, kompozycja farmaceutyczna je zawierająca oraz ich zastosowanie
AU2002230056A1 (en) * 2001-01-29 2002-08-12 Insight Strategy And Marketing Ltd Indole derivatives and their uses as heparanase inhibitors
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
WO2002070478A1 (fr) * 2001-03-06 2002-09-12 Astrazeneca Ab Dérivés indolone capable de dégrader des vaisseaux
US6642232B2 (en) 2001-10-10 2003-11-04 Sugen, Inc. 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors
PL373523A1 (en) * 2002-04-22 2005-09-05 Pfizer Products Inc. Indol-2-ones as selective inhibitors of cyclooxygenase-2
MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
CA2696609C (fr) 2007-08-27 2017-09-05 Helicon Therapeutics, Inc. Composes isoxazole therapeutiques
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
CN102413825A (zh) 2009-04-29 2012-04-11 阿马里纳股份公司 含有epa和心血管剂的药物组合物以及使用其的方法
US8933248B2 (en) 2012-06-21 2015-01-13 Council Of Scientific & Industrial Research 3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
CA2950084C (fr) 2014-06-06 2022-04-19 Basf Se Utilisation d'oxadiazoles substitues pour lutter contre des fongus phytopathogenes
WO2016150937A1 (fr) 2015-03-25 2016-09-29 Lonza Ltd Procédé de préparation de chlorures de thiophènecarbonyle
BR112018009539B1 (pt) 2015-11-13 2022-05-24 Basf Se Uso de compostos da fórmula i, compostos, mistura, composição agroquímica, uso dos compostos e método para combater fungos nocivos fitopatogênicos
AR106679A1 (es) 2015-11-13 2018-02-07 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatógenos
KR20180083419A (ko) 2015-11-19 2018-07-20 바스프 에스이 식물병원성 진균을 퇴치하기 위한 치환 옥사디아졸
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CN115403566B (zh) * 2022-09-21 2024-01-30 山东大学 3-取代吲哚-2-酮化合物及其制备方法和应用

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US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives

Also Published As

Publication number Publication date
PT93785A (pt) 1990-11-20
PL287812A1 (en) 1991-07-15
RU2039042C1 (ru) 1995-07-09
HUT58314A (en) 1992-02-28
CZ284340B6 (cs) 1998-10-14
EP0393936B1 (fr) 1995-02-22
GR3015811T3 (en) 1995-07-31
CN1022832C (zh) 1993-11-24
NZ233320A (en) 1991-09-25
DE69017066D1 (de) 1995-03-30
KR920006394B1 (ko) 1992-08-06
DK0393936T3 (da) 1995-06-26
JP2581525B2 (ja) 1997-02-12
OA09205A (en) 1992-06-30
HU902462D0 (en) 1990-08-28
ZA902871B (en) 1991-11-27
AU1051092A (en) 1992-04-09
ATE118767T1 (de) 1995-03-15
CN1046525A (zh) 1990-10-31
IS1636B (is) 1996-09-20
ES2068334T3 (es) 1995-04-16
KR900016189A (ko) 1990-11-12
BG60646B1 (bg) 1995-11-30
IL94047A (en) 1995-10-31
IL110173A (en) 1997-06-10
JP2506478B2 (ja) 1996-06-12
HU211150A9 (en) 1995-10-30
YU75590A (sh) 1992-07-20
NO176759C (no) 1995-05-24
EG19122A (en) 1994-07-30
IE65091B1 (en) 1995-10-04
PL284817A1 (en) 1991-03-25
AU621477B2 (en) 1992-03-12
NO901684D0 (no) 1990-04-17
CA2014467C (fr) 2000-02-08
AP142A (en) 1991-09-26
CA2014467A1 (fr) 1990-10-18
EP0393936A1 (fr) 1990-10-24
PL163951B1 (pl) 1994-05-31
NO901684L (no) 1990-10-19
US6174883B1 (en) 2001-01-16
PT93785B (pt) 1996-09-30
JPH07118261A (ja) 1995-05-09
IL110173A0 (en) 1994-10-07
RU2073671C1 (ru) 1997-02-20
IE901360L (en) 1990-10-18
CZ184890A3 (cs) 1998-07-15
NO176759B (no) 1995-02-13
BG91773A (bg) 1993-12-24
AP9000175A0 (en) 1990-04-30
AU5362690A (en) 1990-11-22
RO106402B1 (ro) 1993-04-30
US5290802A (en) 1994-03-01
JPH02292258A (ja) 1990-12-03
FI901915A0 (fi) 1990-04-17
MX20359A (es) 1994-02-28
IL94047A0 (en) 1991-01-31
IS3570A7 (is) 1990-10-19
DE69017066T2 (de) 1995-06-14
FI106378B (fi) 2001-01-31
AU633767B2 (en) 1993-02-04
YU47588B (sh) 1995-10-24
PL163941B1 (pl) 1994-05-31
US5047554A (en) 1991-09-10
US5919809A (en) 1999-07-06
DD293822A5 (de) 1991-09-12

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