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LV10863B - Process for preparing 1-substituted-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid, a novel intermediate useful in said process, and a process for preparing said intermediate - Google Patents

Process for preparing 1-substituted-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid, a novel intermediate useful in said process, and a process for preparing said intermediate Download PDF

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Publication number
LV10863B
LV10863B LV931317A LV931317A LV10863B LV 10863 B LV10863 B LV 10863B LV 931317 A LV931317 A LV 931317A LV 931317 A LV931317 A LV 931317A LV 10863 B LV10863 B LV 10863B
Authority
LV
Latvia
Prior art keywords
substituted
fluoro
piperazinyl
general formula
dihydroquinoline
Prior art date
Application number
LV931317A
Other languages
English (en)
Other versions
LV10863A (lv
Inventor
Natasa Zupancic
Martin Barbo
Boris Sket
Pavel Zupet
Original Assignee
Krka Tovarna Zdravil
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil filed Critical Krka Tovarna Zdravil
Publication of LV10863A publication Critical patent/LV10863A/lv
Publication of LV10863B publication Critical patent/LV10863B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Claims (7)

  1. 000¾ kur R·) ir zemākā alikil-, zemākā cikloalkil- vai 2,4-difluorfenilgrupa un R2 ir zemākā aikilgrupa vai pēc izvēles aizvietota fenilgrupa, raksturīgs ar to, ka 1-aizvietotā-6-fluor-7-halogēn-4-oksi-1,4-dihidrohinolīn-3-karboksilāta bora diacetātā, kura vispārējā formula ir (III)
    kur X ir F vai Cl, bet R-ļ ir augšminētais, veic halogēna atoma nukleofllo aivietošanu 7-stāvokfī ar 1-aizvietoto piperazinu, kura formula ir H
    COORg un kur R2 ir augšminētais.
    000¾ kur Rļ ir zemākā alkii-, zemākā cikloalkil- vai 2,4-difluorfenilgrupa un R2 ir zemākā alkii- vai pēc izvēles aizvietota fenilgrupa.
    000¾ kur R ir augšminētais un R2 ir zemākā aikilgrupa vai pēc izvēles aizvietota fenilgrupa, tiek pakļauts sārmainai hidroiizei un, pēc izvēles, iegūto savienojumu ar vispārējo formulu (II) pārveido farmakoloģiski saderīga pievienotās skābes sāli, tādā kā hidrohlorīds vai laktāts un to hidrāti.
  2. 2. 1 -aizvietotais-6-fluor-4-oksi-7-(4-aizvietotais-1 -piperazinil)-1,4- dihidrohinofīn-3-karboksilāta bora diacetāts ar vispārējo formulu (I) AcO OAc
    LV 10863 IZGUDROJUMA FORMULA 1. Paņēmiens 1 -aizvietotās-6-fluor-4-oksi-7-(l -piperazinil)-1,4-dihidrohinofin-3-karbonskābes, kuras vispārējā formula ir (II), izgatavošanai 0
    II kur Ri ir zemākā alkii-, zemākā cikloalkil- vai 2,4-difluorfenilgrupa vai farmokoloģiski saderīga pievienotās skābes sāls, tāda kā hidrohlorīds vai laktāts un to hidrāti, raksturīgs ar to, ka savienojums ar vispārējo formulu (I) AcO OAc
  3. 3. Paņēmiens 1 -aizvietota-6-fluor-4-oksi-7-{4-aizvietotā-1 -piperazinil)-1,4-dihidrohinolīn-3-karboksilāta bora diacetāta, kura vispārējā formula ir (I), iegūšanai
  4. 4. Paņēmiens saskaņā ar 1.punktu, raksturīgs ar to, ka to veic ūdens vai spirta/ūdens vidē.
  5. 5. Paņēmiens saskaņā ar 1 .punktu, raksturīgs ar to, ka to veic temperatūrā no 50°C līdz reakcijas maisījuma flegmas temperatūrai.
  6. 6. Paņēmiens saskaņā ar 3.punktu, raksturīgs ar to, ka to veic organiskā šķīdinātājā, tādā kā piridīns, dimetisufoksīds, dimetilformamīds, 1-metil-2-pirolidons, ieteicamāk 1-metil-2-piroidonā.
  7. 7. Paņēmiens saskaņā ar 3.punktu, raksturīgs ar to, ka to veic temperatūrā no 0° līdz 40°C, ieteicamāk no 20°C līdz 30°C.
LV931317A 1992-12-11 1993-12-10 Process for preparing 1-substituted-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid, a novel intermediate useful in said process, and a process for preparing said intermediate LV10863B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9200377A SI9200377A (en) 1992-12-11 1992-12-11 Process for the preparation of 1-substituted 6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxilic acid, novel intermediate used in this process and process for its preparation

Publications (2)

Publication Number Publication Date
LV10863A LV10863A (lv) 1995-10-20
LV10863B true LV10863B (en) 1996-08-20

Family

ID=20431064

Family Applications (1)

Application Number Title Priority Date Filing Date
LV931317A LV10863B (en) 1992-12-11 1993-12-10 Process for preparing 1-substituted-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid, a novel intermediate useful in said process, and a process for preparing said intermediate

Country Status (13)

Country Link
AT (1) AT401648B (lv)
CA (1) CA2111181A1 (lv)
CZ (1) CZ284715B6 (lv)
EE (1) EE9400277A (lv)
HR (1) HRP931485A2 (lv)
HU (1) HUT75319A (lv)
LT (1) LT3084B (lv)
LV (1) LV10863B (lv)
PL (1) PL173784B1 (lv)
RU (1) RU2127270C1 (lv)
SI (1) SI9200377A (lv)
SK (1) SK140093A3 (lv)
YU (1) YU76593A (lv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003219103B2 (en) * 2002-03-27 2008-10-23 Axovant Sciences Gmbh Quinoline derivatives and their use as 5-HT6 ligands

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE444566B (sv) 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
DE2747357A1 (de) 1977-10-21 1979-04-26 Bayer Ag Substituierte pyrimidinyl(thiono) (thiol)phosphor (phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide und akarizide
JPS5533453A (en) 1978-08-31 1980-03-08 Dainippon Pharmaceut Co Ltd Preventive and remedy for infectious disease of fish
JPS5762259A (en) 1980-09-05 1982-04-15 Kyorin Pharmaceut Co Ltd Preparation of substituted quinolinecarboxylic acid derivative
DE3308909A1 (de) 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel auf chinoloncarbonsaeure-basis
DE8812756U1 (de) 1988-09-22 1988-12-01 Weinschlauch Hemü Weinhandel GmbH, 4000 Düsseldorf Zapfschrank

Also Published As

Publication number Publication date
HU9302940D0 (en) 1993-12-28
PL301045A1 (en) 1994-06-13
SK140093A3 (en) 1994-11-09
ATA249793A (de) 1996-03-15
PL173784B1 (pl) 1998-04-30
YU76593A (sh) 1996-07-24
RU2127270C1 (ru) 1999-03-10
AT401648B (de) 1996-10-25
CA2111181A1 (en) 1994-06-12
LTIP1558A (en) 1994-06-15
LV10863A (lv) 1995-10-20
SI9200377A (en) 1994-06-30
EE9400277A (et) 1996-04-15
CZ284715B6 (cs) 1999-02-17
LT3084B (en) 1994-11-25
HUT75319A (en) 1997-05-28
HRP931485A2 (en) 1995-04-30
CZ264393A3 (en) 1994-07-13

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