LV10083B - Method of preparation of (6s)- and (6r)-tetrahydrofolic acid - Google Patents

Method of preparation of (6s)- and (6r)-tetrahydrofolic acid Download PDF

Info

Publication number: LV10083B
Authority: LV; Latvia
Prior art keywords: acid; tetrahydrofolic; τγφκ; sulphonic; kmcjlotbl
Prior art date: 1991-01-16

Application number

LVP-93-220A

Other languages

English (en)

Latvian (lv)

Other versions

LV10083A (lv

Inventor

Hans Rudolf M Ller

Martin Ulmann

Josef Conti

G Nter M Rdel

Original Assignee

Eprova Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-16

Filing date

1993-04-02

Publication date

1995-04-20

1993-04-02 Application filed by Eprova Ag filed Critical Eprova Ag

1994-05-10 Publication of LV10083A publication Critical patent/LV10083A/xx

1995-04-20 Publication of LV10083B publication Critical patent/LV10083B/lv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Steroid Compounds (AREA)
Liquid Crystal Substances (AREA)
Oscillators With Electromechanical Resonators (AREA)
Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)

LVP-93-220A 1991-01-16 1993-04-02 Method of preparation of (6s)- and (6r)-tetrahydrofolic acid LV10083B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH108/91A CH681303A5 (ru)	1991-01-16	1991-01-16

Publications (2)

Publication Number	Publication Date
LV10083A LV10083A (lv)	1994-05-10
LV10083B true LV10083B (en)	1995-04-20

Family

ID=4179454

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-220A LV10083B (en)	1991-01-16	1993-04-02	Method of preparation of (6s)- and (6r)-tetrahydrofolic acid

Country Status (25)

Country	Link
US (1)	US5324836A (ru)
EP (1)	EP0495204B1 (ru)
JP (1)	JPH0739417B2 (ru)
KR (1)	KR100207133B1 (ru)
CN (1)	CN1030079C (ru)
AT (1)	ATE123777T1 (ru)
AU (1)	AU654993B2 (ru)
CA (1)	CA2059103C (ru)
CH (1)	CH681303A5 (ru)
DE (1)	DE59105722D1 (ru)
DK (1)	DK0495204T3 (ru)
ES (1)	ES2075315T3 (ru)
FI (1)	FI109906B (ru)
GE (1)	GEP19971019B (ru)
HU (1)	HU207083B (ru)
IE (1)	IE72164B1 (ru)
IL (1)	IL100478A (ru)
LV (1)	LV10083B (ru)
MX (1)	MX9200063A (ru)
NO (1)	NO301422B1 (ru)
NZ (1)	NZ241245A (ru)
PT (1)	PT100014B (ru)
RU (1)	RU2099340C1 (ru)
TW (1)	TW198033B (ru)
ZA (1)	ZA92291B (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH682664A5 (en) *	1991-10-15	1993-10-29	Eprova Ag	Stable salts of 5,10-methylene tetrahydrofolate.
DE4136921A1 (de) *	1991-11-11	1993-05-13	Knoll Ag	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683262A5 (it) *	1992-01-22	1994-02-15	Applied Pharma Res	Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
IT1254635B (it) *	1992-02-20	1995-09-28	Bracco Spa	Processo per la separazione degli stereoisomeri dell'acido folinico
CH684644A5 (de)	1992-07-13	1994-11-15	Eprova Ag	5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
CH686672A5 (de) *	1992-12-01	1996-05-31	Cerbios Pharma Sa	Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
CH686369A5 (de) *	1994-05-09	1996-03-15	Eprova Ag	Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
CH689831A5 (de) *	1995-11-07	1999-12-15	Eprova Ag	Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de)	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH694251A5 (de) *	1999-07-14	2004-10-15	Eprova Ag	Herstellung von Tetrahydropterin und Derivaten.
CH695217A5 (de) *	1999-07-14	2006-01-31	Merck Eprova Ag	Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
AU2002241918B2 (en)	2001-01-16	2007-01-18	Gr Intellectual Reserve, Llc	Enhanced data storage and retrieval devices and systems and methods for utilizing the same
ITMI20020132A1 (it) *	2002-01-25	2003-07-25	Gmt Fine Chemicals Sa	Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
AU2003303150A1 (en)	2002-11-21	2004-07-14	Berkshire Laboratories, Inc.	Enhanced data storage and retrieval devices and systems and methods for utilizing same
CH696717A5 (de) *	2004-02-20	2007-10-31	Cerbios Pharma Sa	Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
CH698729B1 (de)	2007-05-30	2009-10-15	Cerbios Pharma Sa	Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN101407518A (zh) *	2007-10-11	2009-04-15	南京莱尔生物化工有限公司	(6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
JP5925381B2 (ja)	2012-04-13	2016-05-25	▲連雲▼港金康和信▲薬業▼有限公司ＬｉａｎｙｕｎｇａｎｇＪｉｎｋａｎｇＨｅｘｉｎＰｈａｒｍａｃｅｕｔｉｃａｌＣｏ．，Ｌｔｄ．	化合物［４−（２−アミノ−１０−メチル−４−オキソ−６，７，８，９−テトラヒドロ−４ａ，７−エピミノピリミド［４，５−ｂ］［１，４］ジアゼピン−５（４Ｈ）−イル）ベンゾイル］−グルタメート及びその製造
CN104045640B (zh) *	2013-03-14	2016-04-06	天津康鸿医药科技发展有限公司	一种制备高纯度左亚叶酸钙的方法
CN104774169B (zh) *	2014-01-15	2017-02-15	上海韶远试剂有限公司	一种利用非手性助剂进行非对映异构体拆分的新方法
CN108164531B (zh) *	2018-02-12	2019-11-05	江苏红豆杉药业有限公司	一种l-5-甲基四氢叶酸钙的制备方法
AU2019297309B2 (en)	2018-07-06	2024-08-29	Merck Patent Gmbh	Crystalline salt of 5-methyl-(6S)-tetrahydrofolic acid and L-isoleucine ethyl ester

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3468886A (en) *	1967-10-23	1969-09-23	Us Health Education & Welfare	Tetrahydrohomofolic acid sulfate and synthesis thereof
DE2063027A1 (de) *	1969-12-26	1971-07-01	Yamanouchi Pharmaceutical Co Ltd , Tokio	Salz einer basischen Aminosäure der 5 6,7,8 Tetrahydrofolsaure
JPS4832120A (ru) *	1971-08-31	1973-04-27
US4665176A (en) *	1984-10-23	1987-05-12	Mitsui Toatsu Chemicals, Incorporated	Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) *	1986-09-03	1986-10-08	Univ Strathclyde	Separation of substances
CH673459A5 (ru) *	1987-05-15	1990-03-15	Eprova Ag
DE3821875C1 (ru) *	1988-06-29	1990-02-15	Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
JPH0265787A (ja) *	1988-08-30	1990-03-06	Kyowa Hakko Kogyo Co Ltd	Ｌ（‐）‐テトラヒドロ葉酸の製造法
CH676981A5 (ru) *	1988-11-11	1991-03-28	Eprova Ag
FR2643081B1 (fr) *	1989-02-14	1991-06-07	Panmedica Sa	Folates de magnesium, procede de preparation et compositions pharmaceutiques
US5173488A (en) *	1989-08-21	1992-12-22	American Cyanamid Company	Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
ES2090075T3 (es) *	1989-12-11	1996-10-16	American Cyanamid Co	Procedimiento para la preparacion de diastereoisomeros opticamente puros de compuestos de tetrahidrofolato.
CH680731A5 (ru) *	1990-04-12	1992-10-30	Sapec Fine Chemicals

1991
- 1991-01-16 CH CH108/91A patent/CH681303A5/de not_active IP Right Cessation
- 1991-11-27 TW TW080109353A patent/TW198033B/zh active
- 1991-12-06 RU SU915010253A patent/RU2099340C1/ru not_active IP Right Cessation
- 1991-12-12 ES ES91121326T patent/ES2075315T3/es not_active Expired - Lifetime
- 1991-12-12 EP EP91121326A patent/EP0495204B1/de not_active Expired - Lifetime
- 1991-12-12 DE DE59105722T patent/DE59105722D1/de not_active Expired - Lifetime
- 1991-12-12 AT AT91121326T patent/ATE123777T1/de not_active IP Right Cessation
- 1991-12-12 DK DK91121326.2T patent/DK0495204T3/da not_active Application Discontinuation
- 1991-12-23 IL IL10047891A patent/IL100478A/en not_active IP Right Cessation
1992
- 1992-01-08 NZ NZ241245A patent/NZ241245A/en not_active IP Right Cessation
- 1992-01-08 MX MX9200063A patent/MX9200063A/es unknown
- 1992-01-09 CA CA002059103A patent/CA2059103C/en not_active Expired - Lifetime
- 1992-01-10 KR KR1019920000260A patent/KR100207133B1/ko not_active IP Right Cessation
- 1992-01-14 JP JP4005095A patent/JPH0739417B2/ja not_active Expired - Lifetime
- 1992-01-15 PT PT100014A patent/PT100014B/pt not_active IP Right Cessation
- 1992-01-15 FI FI920180A patent/FI109906B/fi active
- 1992-01-15 NO NO920197A patent/NO301422B1/no not_active IP Right Cessation
- 1992-01-15 ZA ZA92291A patent/ZA92291B/xx unknown
- 1992-01-15 HU HU9200134A patent/HU207083B/hu not_active IP Right Cessation
- 1992-01-15 CN CN92100247A patent/CN1030079C/zh not_active Expired - Lifetime
- 1992-01-15 IE IE920112A patent/IE72164B1/en not_active IP Right Cessation
- 1992-01-15 AU AU10254/92A patent/AU654993B2/en not_active Ceased
1993
- 1993-04-02 LV LVP-93-220A patent/LV10083B/lv unknown
- 1993-04-08 US US08/044,886 patent/US5324836A/en not_active Expired - Lifetime
- 1993-07-14 GE GEAP19931024A patent/GEP19971019B/en unknown

Also Published As

Publication number	Publication date
EP0495204B1 (de)	1995-06-14
FI109906B (fi)	2002-10-31
JPH0739417B2 (ja)	1995-05-01
HU207083B (en)	1993-03-01
MX9200063A (es)	1993-01-01
ATE123777T1 (de)	1995-06-15
NZ241245A (en)	1993-11-25
GEP19971019B (en)	1997-05-22
HU9200134D0 (en)	1992-04-28
RU2099340C1 (ru)	1997-12-20
ZA92291B (en)	1992-09-30
NO920197D0 (no)	1992-01-15
CA2059103A1 (en)	1992-07-17
DE59105722D1 (de)	1995-07-20
IL100478A0 (en)	1992-09-06
KR920014812A (ko)	1992-08-25
IE72164B1 (en)	1997-03-26
NO301422B1 (no)	1997-10-27
CN1030079C (zh)	1995-10-18
CN1063285A (zh)	1992-08-05
FI920180A (fi)	1992-07-17
JPH04312586A (ja)	1992-11-04
CH681303A5 (ru)	1993-02-26
HUT60272A (en)	1992-08-28
IE920112A1 (en)	1992-07-29
NO920197L (no)	1992-07-17
CA2059103C (en)	1996-12-17
LV10083A (lv)	1994-05-10
AU1025492A (en)	1992-07-23
PT100014B (pt)	1999-08-31
KR100207133B1 (ko)	1999-07-15
IL100478A (en)	1999-03-12
US5324836A (en)	1994-06-28
DK0495204T3 (da)	1995-08-07
PT100014A (pt)	1993-03-31
AU654993B2 (en)	1994-12-01
FI920180A0 (fi)	1992-01-15
EP0495204A1 (de)	1992-07-22
TW198033B (ru)	1993-01-11
ES2075315T3 (es)	1995-10-01

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US4117126A (en)	1978-09-26	7-(α-(4-Hydroxy-1,5-naphthyridine-3-carbonamido)-α-phenylacetamido) cephalosporin derivatives
US3884915A (en)	1975-05-20	7-Alkylmercaptoacetamido cephalosporins
CA1038759A (en)	1978-09-19	Mixtures of cephalosporin and penicillin type antibiotics
US3341532A (en)	1967-09-12	Substituted 7-acetylamino cephalosporanic acids
Randolph et al.	1979	Comparative bactericidal effect of ceforanide (BL-S 786) and five other cephalosporins in an in vitro pharmacokinetic model
RODRÍGUEZ‐TÉBAR et al.	1982	Interaction of β‐Lactam Antibiotics with Penicillin‐Binding Proteins from Bacillus megaterium
Umegaki et al.	1985	The appearance of “exhausted” platelets at the time of stroke in stroke-prone spontaneously hypertensive rats
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