[go: up one dir, main page]

LU83833A1 - Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl) butyl)-8-azaspiro (4,5)-decane-7,9-dione." - Google Patents

Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl) butyl)-8-azaspiro (4,5)-decane-7,9-dione." Download PDF

Info

Publication number
LU83833A1
LU83833A1 LU83833A LU83833A LU83833A1 LU 83833 A1 LU83833 A1 LU 83833A1 LU 83833 A LU83833 A LU 83833A LU 83833 A LU83833 A LU 83833A LU 83833 A1 LU83833 A1 LU 83833A1
Authority
LU
Luxembourg
Prior art keywords
dione
azaspiro
piperazinyl
formula
pyrimidinyl
Prior art date
Application number
LU83833A
Other languages
English (en)
French (fr)
Inventor
D Temple Jr
R Covington
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of LU83833A1 publication Critical patent/LU83833A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LU83833A 1980-12-11 1981-12-11 Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl) butyl)-8-azaspiro (4,5)-decane-7,9-dione." LU83833A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21521480A 1980-12-11 1980-12-11
US21521480 1980-12-11

Publications (1)

Publication Number Publication Date
LU83833A1 true LU83833A1 (fr) 1982-07-07

Family

ID=22802113

Family Applications (1)

Application Number Title Priority Date Filing Date
LU83833A LU83833A1 (fr) 1980-12-11 1981-12-11 Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl) butyl)-8-azaspiro (4,5)-decane-7,9-dione."

Country Status (18)

Country Link
JP (1) JPS57122082A (xx)
AT (1) AT380686B (xx)
AU (1) AU528067B2 (xx)
BE (1) BE891446A (xx)
CA (1) CA1172255A (xx)
CH (1) CH647518A5 (xx)
DE (1) DE3149011A1 (xx)
DK (1) DK154560C (xx)
FI (1) FI73993C (xx)
FR (1) FR2496105B1 (xx)
GB (1) GB2089341B (xx)
GR (1) GR76331B (xx)
IE (1) IE51948B1 (xx)
IT (1) IT1172073B (xx)
LU (1) LU83833A1 (xx)
NL (1) NL8105529A (xx)
SE (1) SE444438B (xx)
YU (1) YU42432B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212301B (en) * 1989-04-28 1996-05-28 Alkaloida Vegyeszeti Gyar Process for producing buspirone
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
KR950014099A (ko) * 1993-11-10 1995-06-15 장기하 N-(2-피리미딜)피페라지닐 부틸아미드의 제조방법
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
DE2341925A1 (de) * 1973-08-20 1975-03-06 Thomae Gmbh Dr K Neue pyrimidinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DE3149011C2 (xx) 1988-08-25
SE8107446L (sv) 1982-06-12
FI73993B (fi) 1987-08-31
YU42432B (en) 1988-08-31
GB2089341B (en) 1984-09-19
IT8149718A0 (it) 1981-11-16
GB2089341A (en) 1982-06-23
BE891446A (fr) 1982-06-11
DK548081A (da) 1982-06-12
ATA529581A (de) 1985-11-15
GR76331B (xx) 1984-08-04
DE3149011A1 (de) 1982-07-15
FR2496105A1 (fr) 1982-06-18
FI73993C (fi) 1987-12-10
FI813937L (fi) 1982-06-12
CA1172255A (en) 1984-08-07
AU7604181A (en) 1982-07-15
YU243681A (en) 1984-02-29
JPS57122082A (en) 1982-07-29
DK154560C (da) 1989-04-17
IT1172073B (it) 1987-06-18
NL8105529A (nl) 1982-07-01
IE812897L (en) 1982-06-11
JPH0113476B2 (xx) 1989-03-06
CH647518A5 (de) 1985-01-31
IE51948B1 (en) 1987-04-29
AU528067B2 (en) 1983-04-14
DK154560B (da) 1988-11-28
FR2496105B1 (fr) 1985-12-13
SE444438B (sv) 1986-04-14
AT380686B (de) 1986-06-25

Similar Documents

Publication Publication Date Title
EP2010498B1 (en) Synthesis of acylaminoalkenylene amides useful as substance p antagonists
LU84561A1 (fr) 2-(4-((4,4,-dialcoyl-2,6-piperidinedione-1-yl)butyl)-1-piperazinyl)pyrimidines
WO2015103142A1 (en) 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1- (arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation
JP2008516005A (ja) レトロゾールの改良された調製方法
US20080275265A1 (en) Process for the Preparation of (Aminoalkylamino)Alkyl Halides and Conversion to Amifostine
RU2174978C2 (ru) Способ получения производных пиримидина, промежуточные продукты и способ их получения
EP1982983B1 (en) Improved process for producing moxonidine
EP0406112B1 (fr) 1-Benzhydrylazétidines, leur préparation et leur application comme intermédiaires pour la préparation de composés à activité antimicrobienne
EP0790236B1 (en) Pro-drugs of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
LU83833A1 (fr) Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl) butyl)-8-azaspiro (4,5)-decane-7,9-dione."
KR100249594B1 (ko) 5-알콕시(1,2,4)트리아졸로(1,5-c)피리미딘-2(3h)-티온화합물, 및 2,2'-디티오비스(5-알콕시(1,2,4)트리아졸로(1,5-c)-피리미딘) 및 2-클로로설포닐-5-알콕시(1,2,4)트리아졸로(1,5-c)피리미딘 화합물의 제조에 있어서의 이의 용도
JP2002544184A (ja) （１ｒ，２ｓ，４ｒ）−（−）−２−［（２’−｛ｎ，ｎ−ジメチルアミノ｝−エトキシ）］−２−［フェニル］−１，７，７−トリ−［メチル］−ビシクロ［２．２．１］ヘプタン及びその薬学上許容される酸付加塩の製法
JPH0121141B2 (xx)
EP3281941B1 (en) Process for preparing 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid
US20080033207A1 (en) Preparation of R-5- (2-(2-Ethoxyphenoxyetylamino) -2-Methoxybenzen-Sulphonamide Hydrochloride of High Chemical
EP3144393A1 (en) A synthetic pathway towards apremilast
JP3617053B2 (ja) ５−アルコキシ−１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３（２Ｈ）−チオン化合物、ならびに５−アルコキシ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン−２（３Ｈ）−チオン及び３−ヒドロカルビルチオ−５−アルコキシ−１，２，４−トリアゾロ［４，３−ｃ］ピリミジンの製造におけるそれらの利用
US4560764A (en) Synthesis of an imidazolyl isothiourea
FR2772378A1 (fr) Derives d'imidazole, leur preparation et leur application en therapeutique
JPH08505410A (ja) ２−アルコキシ−４−ヒドラジノピリミジン化合物及び５−アルコキシ−１，２，４−トリアゾロ［４，３−ｃピリミジン−３（２Ｈ）−チオン化合物の製造におけるそれらの利用
RU2238269C1 (ru) Способ получения 6-замещенных 2-(алкилсульфанил)-4(3н)-пиримидинонов
US20040106829A1 (en) Process for the synthesis of modafinil
EP0713865A1 (fr) Dérivés d'acide 2-aminobenzènesulfonique et de chlorure de 2-aminobenzènesulfonyle, leur préparation et leur utilisation comme intermédiaires de synthèse
US4703121A (en) Process for the preparation of 5-fluorocytosine
ES2355849T3 (es) Síntesis de acilaminoalquenileno amidas útiles como antagonistas de sustancia p.