LU82452A1 - Bis-esters de methanediol avec des penicillines et le 1,1-dioxyde d'acide penicillanique,leur procede de production et composition pharmaceutique les contenant - Google Patents

Bis-esters de methanediol avec des penicillines et le 1,1-dioxyde d'acide penicillanique,leur procede de production et composition pharmaceutique les contenant Download PDF

Info

Publication number: LU82452A1
Authority: LU; Luxembourg
Prior art keywords: compound; formula; amino; group; dioxide
Prior art date: 1979-05-16

Application number

LU82452A

Other languages

English (en)

French (fr)

Inventor

E Bigham

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-16

Filing date

1980-05-14

Publication date

1980-12-16

1980-05-14 Application filed by Pfizer filed Critical Pfizer

1980-12-16 Publication of LU82452A1 publication Critical patent/LU82452A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
- C07D499/32—Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

LU82452A 1979-05-16 1980-05-14 Bis-esters de methanediol avec des penicillines et le 1,1-dioxyde d'acide penicillanique,leur procede de production et composition pharmaceutique les contenant LU82452A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3953979		1979-05-16
US06/039,539 US4244951A (en)	1979-05-16	1979-05-16	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Publications (1)

Publication Number	Publication Date
LU82452A1 true LU82452A1 (fr)	1980-12-16

Family

ID=21906015

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU82452A LU82452A1 (fr)	1979-05-16	1980-05-14	Bis-esters de methanediol avec des penicillines et le 1,1-dioxyde d'acide penicillanique,leur procede de production et composition pharmaceutique les contenant

Country Status (44)

Country	Link
US (1)	US4244951A (hu)
JP (1)	JPS55157589A (hu)
KR (1)	KR840000105B1 (hu)
AR (1)	AR226062A1 (hu)
AT (2)	AT369373B (hu)
AU (1)	AU520066B2 (hu)
BE (1)	BE883299A (hu)
BG (1)	BG35467A3 (hu)
CA (1)	CA1200545A (hu)
CH (1)	CH646177A5 (hu)
CS (1)	CS276964B6 (hu)
DD (1)	DD150898A5 (hu)
DE (2)	DE3050440A1 (hu)
DK (1)	DK159786C (hu)
EC (1)	ECSP941080A (hu)
EG (1)	EG15129A (hu)
ES (1)	ES8104300A1 (hu)
FI (1)	FI71742C (hu)
FR (2)	FR2456745A1 (hu)
GB (2)	GB2081269B (hu)
GR (1)	GR68468B (hu)
GT (1)	GT198063473A (hu)
HK (2)	HK66787A (hu)
HU (1)	HU184754B (hu)
IE (1)	IE49892B1 (hu)
IL (1)	IL60074A (hu)
IN (1)	IN154371B (hu)
IT (1)	IT1131187B (hu)
KE (2)	KE3460A (hu)
LU (1)	LU82452A1 (hu)
MX (1)	MX6717E (hu)
MY (2)	MY8500322A (hu)
NL (1)	NL8002793A (hu)
NO (3)	NO801415L (hu)
NZ (1)	NZ193713A (hu)
PH (3)	PH16554A (hu)
PL (2)	PL127434B1 (hu)
PT (1)	PT71248A (hu)
RO (2)	RO84151B (hu)
SE (1)	SE449749B (hu)
SG (1)	SG56284G (hu)
SU (2)	SU1122226A3 (hu)
YU (1)	YU41925B (hu)
ZA (1)	ZA801885B (hu)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE49880B1 (en) *	1979-02-13	1986-01-08	Leo Pharm Prod Ltd	Penicillin derivatives
US4309347A (en) *	1979-05-16	1982-01-05	Pfizer Inc.	Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
DE3051044C2 (hu) *	1979-06-19	1989-03-30	Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4364957A (en) *	1979-09-26	1982-12-21	Pfizer Inc.	Bis-esters of alkanediols as antibacterial agents
US4342768A (en) *	1979-10-22	1982-08-03	Pfizer Inc.	Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
IL61880A (en) *	1980-01-21	1984-11-30	Bristol Myers Co	2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4488994A (en) *	1980-09-08	1984-12-18	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IE51516B1 (en) *	1980-10-06	1987-01-07	Leo Pharm Prod Ltd	1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate
IL64009A (en) *	1980-10-31	1984-09-30	Rech Applications Therap	Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them
US4474698A (en) *	1980-12-11	1984-10-02	Pfizer Inc.	Process for preparing esters of penicillanic acid sulfone
US4323499A (en) *	1981-01-05	1982-04-06	Pfizer Inc.	6-(2-Aryl-2-(1,1-dioxopenicillanoyloxy-methoxycarbonyl)acetamido penicillanic acids
US4478748A (en) *	1981-02-20	1984-10-23	Pfizer Inc.	Bis-esters of alkanediols
US4321196A (en) *	1981-03-23	1982-03-23	Pfizer Inc.	Bis-esters of methanediol with acetonides of ampicillin or amoxicillin and penicillanic acid 1,1-dioxide
IN157669B (hu) *	1981-03-23	1986-05-17	Pfizer
US4376076A (en) *	1981-03-23	1983-03-08	Pfizer Inc.	Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide
US4393001A (en) *	1981-03-23	1983-07-12	Pfizer Inc.	Intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates
US4381263A (en) *	1981-03-23	1983-04-26	Pfizer Inc.	Process for the preparation of penicillanic acid esters
US4540687A (en) *	1981-09-09	1985-09-10	Pfizer Inc.	Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
US4582829A (en) *	1981-09-09	1986-04-15	Pfizer Inc.	Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
ZA826687B (en) *	1981-09-14	1983-07-27	Pfizer	Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4351840A (en) *	1981-09-18	1982-09-28	Pfizer Inc.	Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
US4457924A (en) *	1981-12-22	1984-07-03	Pfizer, Inc.	1,1-Alkanediol dicarboxylate linked antibacterial agents
US4359472A (en) *	1981-12-22	1982-11-16	Pfizer Inc.	Bis-hydroxymethyl carbonate bridged antibacterial agents
US4452796A (en) *	1982-06-14	1984-06-05	Pfizer Inc.	6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
EP0084730A1 (en) *	1982-01-22	1983-08-03	Beecham Group Plc	Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use
US4444686A (en) *	1982-01-25	1984-04-24	Pfizer Inc.	Crystalline penicillin ester intermediate
US4432987A (en) *	1982-04-23	1984-02-21	Pfizer Inc.	Crystalline benzenesulfonate salts of sultamicillin
US4377590A (en) *	1982-05-10	1983-03-22	Pfizer Inc.	Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
US4428935A (en)	1982-05-24	1984-01-31	Pfizer Inc.	Penicillanic acid dioxide prodrug
US4375434A (en) *	1982-06-21	1983-03-01	Pfizer Inc.	Process for 6'-amino-penicillanoyloxymethyl penicillanate 1,1-dioxide
US4530792A (en) *	1982-11-01	1985-07-23	Pfizer Inc.	Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
US4868297A (en) *	1982-12-06	1989-09-19	Pfizer Inc.	Process for preparing sultamicillin and analogs
US4462934A (en)	1983-03-31	1984-07-31	Pfizer Inc.	Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
US4536393A (en) *	1983-06-06	1985-08-20	Pfizer Inc.	6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
JPS60214792A (ja) *	1984-04-06	1985-10-28	Taiho Yakuhin Kogyo Kk	ペナム酸エステル誘導体
JPH01139584A (ja) *	1987-11-25	1989-06-01	Yoshitomi Pharmaceut Ind Ltd	ペニシラン酸化合物の製造法
GB8808001D0 (en) *	1988-04-06	1988-05-05	Scras	Stereospecific preparative process for furol(3,4-c)pyridine derivatives
GB8808701D0 (en) *	1988-04-13	1988-05-18	Erba Carlo Spa	Beta-lactam derivatives
GB2231049A (en) *	1989-04-14	1990-11-07	Yoshitomi Pharmaceutical	Method for producing diester compounds
KR910009271B1 (ko) *	1989-06-20	1991-11-08	김영설	1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
KR0164866B1 (ko) *	1990-04-13	1999-01-15	알렌 제이. 스피겔	설타마이실린 중간체의 제조방법
CN100384857C (zh) *	2003-11-28	2008-04-30	浙江永宁制药厂	耐β-内酰胺酶的头孢菌素酯化合物及其盐
IT202000031070A1 (it)	2020-12-16	2022-06-16	Paolo Bonomi	Procedimento di sintesi di derivati ammidici dell’acido 8-idrossi penicillanico
CN115385934A (zh) *	2022-10-26	2022-11-25	北京纳百生物科技有限公司	一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (10)

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Publication number	Priority date	Publication date	Assignee	Title
IE34948B1 (en) *	1970-03-12	1975-10-01	Leo Pharm Prod Ltd	New penicillin esters
GB1303491A (hu) *	1970-03-24	1973-01-17
GB1335718A (en) *	1971-05-05	1973-10-31	Leo Pharm Prod Ltd	Penicillin esters salts thereof and methods for their preparation
US3838152A (en) *	1971-10-07	1974-09-24	American Home Prod	Poly alpha-amino penicillins
DE2460477A1 (de) *	1973-12-26	1975-07-10	Yamanouchi Pharma Co Ltd	Verbessertes verfahren zur herstellung von 6-alkoxy-substituierten penicillinen
GB1467604A (en) *	1974-06-27	1977-03-16	Toyama Chemical Co Ltd	Bis-type penicillins and process for producing the same
GB1578128A (en) *	1976-03-30	1980-11-05	Leo Pharm Prod Ltd	Amidinopenicillanoyloxyalkyl amoxycillinates
IN149747B (hu) *	1977-06-07	1982-04-03	Pfizer
IE49880B1 (en) *	1979-02-13	1986-01-08	Leo Pharm Prod Ltd	Penicillin derivatives
ZA80796B (en) *	1979-02-13	1981-02-25	Leo Pharm Prod Ltd	Chemical compounds

1979
- 1979-05-16 US US06/039,539 patent/US4244951A/en not_active Expired - Lifetime
1980
- 1980-03-31 ZA ZA00801885A patent/ZA801885B/xx unknown
- 1980-04-22 IN IN290/DEL/80A patent/IN154371B/en unknown
- 1980-05-08 SU SU802921352A patent/SU1122226A3/ru active
- 1980-05-08 CS CS803252A patent/CS276964B6/cs not_active IP Right Cessation
- 1980-05-08 HU HU801136A patent/HU184754B/hu unknown
- 1980-05-09 RO RO108682A patent/RO84151B/ro unknown
- 1980-05-09 RO RO80101076A patent/RO80220A/ro unknown
- 1980-05-09 BG BG047702A patent/BG35467A3/xx unknown
- 1980-05-13 CA CA000351802A patent/CA1200545A/en not_active Expired
- 1980-05-13 NO NO801415A patent/NO801415L/no unknown
- 1980-05-13 FI FI801546A patent/FI71742C/fi not_active IP Right Cessation
- 1980-05-13 SE SE8003603A patent/SE449749B/sv not_active IP Right Cessation
- 1980-05-14 ES ES491534A patent/ES8104300A1/es not_active Expired
- 1980-05-14 FR FR8010886A patent/FR2456745A1/fr active Granted
- 1980-05-14 PL PL1980224225A patent/PL127434B1/pl unknown
- 1980-05-14 PH PH24029A patent/PH16554A/en unknown
- 1980-05-14 PL PL1980230846A patent/PL127283B1/pl unknown
- 1980-05-14 NZ NZ193713A patent/NZ193713A/en unknown
- 1980-05-14 NL NL8002793A patent/NL8002793A/nl not_active Application Discontinuation
- 1980-05-14 DK DK211880A patent/DK159786C/da active
- 1980-05-14 LU LU82452A patent/LU82452A1/fr unknown
- 1980-05-14 MX MX808811U patent/MX6717E/es unknown
- 1980-05-14 BE BE0/200615A patent/BE883299A/fr not_active IP Right Cessation
- 1980-05-14 DE DE19803050440 patent/DE3050440A1/de active Pending
- 1980-05-14 GR GR61944A patent/GR68468B/el unknown
- 1980-05-14 AU AU58396/80A patent/AU520066B2/en not_active Expired
- 1980-05-14 DE DE19803018590 patent/DE3018590A1/de not_active Withdrawn
- 1980-05-14 AR AR281014A patent/AR226062A1/es active
- 1980-05-14 IL IL60074A patent/IL60074A/xx unknown
- 1980-05-14 AT AT0258880A patent/AT369373B/de active
- 1980-05-14 CH CH380680A patent/CH646177A5/de not_active IP Right Cessation
- 1980-05-15 JP JP6465480A patent/JPS55157589A/ja active Granted
- 1980-05-15 IE IE1007/80A patent/IE49892B1/en not_active IP Right Cessation
- 1980-05-15 GB GB8127095A patent/GB2081269B/en not_active Expired
- 1980-05-15 IT IT22097/80A patent/IT1131187B/it active
- 1980-05-15 PT PT71248A patent/PT71248A/pt unknown
- 1980-05-15 KR KR1019800001917A patent/KR840000105B1/ko active
- 1980-05-15 YU YU1303/80A patent/YU41925B/xx unknown
- 1980-05-15 GB GB8016136A patent/GB2051057B/en not_active Expired
- 1980-05-16 GT GT198063473A patent/GT198063473A/es unknown
- 1980-05-16 DD DD80221170A patent/DD150898A5/de unknown
- 1980-05-17 EG EG308/80A patent/EG15129A/xx active
1981
- 1981-02-20 FR FR8103436A patent/FR2477154A1/fr active Granted
- 1981-04-27 PH PH25556A patent/PH15539A/en unknown
- 1981-04-27 SU SU813274747A patent/SU1122228A3/ru active
- 1981-04-27 PH PH25555A patent/PH15706A/en unknown
1982
- 1982-01-18 AT AT0016082A patent/AT377522B/de not_active IP Right Cessation
1983
- 1983-03-23 NO NO831026A patent/NO831026L/no unknown
- 1983-03-23 NO NO831025A patent/NO831025L/no unknown
1984
- 1984-08-13 SG SG562/84A patent/SG56284G/en unknown
- 1984-09-24 KE KE3460A patent/KE3460A/xx unknown
- 1984-09-24 KE KE3457A patent/KE3457A/xx unknown
1985
- 1985-12-30 MY MY322/85A patent/MY8500322A/xx unknown
- 1985-12-30 MY MY324/85A patent/MY8500324A/xx unknown
1987
- 1987-09-17 HK HK667/87A patent/HK66787A/xx not_active IP Right Cessation
- 1987-09-17 HK HK669/87A patent/HK66987A/xx not_active IP Right Cessation
1994
- 1994-05-05 EC EC1994001080A patent/ECSP941080A/es unknown

Also Published As

Publication number	Publication date
ES491534A0 (es)	1981-04-01
AU5839680A (en)	1980-11-20
SE449749B (sv)	1987-05-18
CS325280A3 (en)	1992-05-13
PH15539A (en)	1983-02-09
DK211880A (da)	1980-11-17
FI801546A (fi)	1980-11-17
IE801007L (en)	1980-11-16
PH15706A (en)	1983-03-14
CA1200545A (en)	1986-02-11
PL127434B1 (en)	1983-10-31
CS276964B6 (en)	1992-11-18
FI71742C (fi)	1987-02-09
NZ193713A (en)	1984-05-31
ATA258880A (de)	1982-05-15
GB2081269A (en)	1982-02-17
BE883299A (fr)	1980-11-14
IT8022097A0 (it)	1980-05-15
IL60074A0 (en)	1980-07-31
PH16554A (en)	1983-11-16
ES8104300A1 (es)	1981-04-01
KE3457A (en)	1984-10-12
PT71248A (en)	1980-06-01
RO84151A (ro)	1984-05-23
PL127283B1 (en)	1983-10-31
DK159786B (da)	1990-12-03
IL60074A (en)	1983-09-30
RO84151B (ro)	1984-07-30
BG35467A3 (en)	1984-04-15
SU1122226A3 (ru)	1984-10-30
US4244951A (en)	1981-01-13
MX6717E (es)	1985-11-07
DE3050440A1 (hu)	1982-07-29
GT198063473A (es)	1981-11-07
HK66787A (en)	1987-09-25
YU41925B (en)	1988-02-29
ECSP941080A (es)	1995-02-27
CH646177A5 (de)	1984-11-15
FR2477154A1 (fr)	1981-09-04
IT1131187B (it)	1986-06-18
AT369373B (de)	1982-12-27
JPS55157589A (en)	1980-12-08
FR2456745B1 (hu)	1983-08-19
HK66987A (en)	1987-09-25
NO801415L (no)	1980-11-17
AU520066B2 (en)	1982-01-14
NO831025L (no)	1980-11-17
FR2456745A1 (fr)	1980-12-12
AT377522B (de)	1985-03-25
IE49892B1 (en)	1986-01-08
KE3460A (en)	1984-10-12
GB2051057A (en)	1981-01-14
HU184754B (en)	1984-10-29
EG15129A (en)	1985-12-31
ATA16082A (de)	1984-08-15
IN154371B (hu)	1984-10-20
MY8500322A (en)	1985-12-31
SE8003603L (sv)	1980-11-17
YU130380A (en)	1983-02-28
SG56284G (en)	1985-03-08
RO80220A (ro)	1982-10-26
KR830002772A (ko)	1983-05-30
AR226062A1 (es)	1982-05-31
JPS6318595B2 (hu)	1988-04-19
MY8500324A (en)	1985-12-31
PL224225A1 (hu)	1981-02-13
DD150898A5 (de)	1981-09-23
NL8002793A (nl)	1980-11-18
DE3018590A1 (de)	1980-11-20
ZA801885B (en)	1981-04-29
NO831026L (no)	1980-11-17
DK159786C (da)	1991-04-22
KR840000105B1 (ko)	1984-02-11
FR2477154B1 (hu)	1983-08-19
GB2081269B (en)	1983-01-19
FI71742B (fi)	1986-10-31
GB2051057B (en)	1983-02-09
SU1122228A3 (ru)	1984-10-30
GR68468B (hu)	1982-01-04

Publication	Publication Date	Title
LU82452A1 (fr)	1980-12-16	Bis-esters de methanediol avec des penicillines et le 1,1-dioxyde d'acide penicillanique,leur procede de production et composition pharmaceutique les contenant
EP0036812B1 (fr)	1985-01-30	Nouveaux dérivés des céphalosporines, leur procédé de préparation et les médicaments utilisables comme antibiotiques qui contiennent lesdits dérivés
LU82164A1 (fr)	1980-09-24	-lactames derives de l acide penicillanique, leur preparation et leurs utilisations therapeutiques
CH634073A5 (en)	1983-01-14	1,1-Dioxides of penicillanic acid and its esters which are useful as beta-lactamase inhibitors
DE2633193A1 (de)	1977-02-10	Neue, antibakteriell wirksame verbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
EP1493739A1 (fr)	2005-01-05	Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
FR2465736A1 (fr)	1981-03-27	Composes penam acetoxymethyles et composition pharmaceutique les contenant
CH621125A5 (hu)	1981-01-15
CH688319A5 (fr)	1997-07-31	Procédé pour la préparation du céfixime trihydraté.
IE54771B1 (en)	1990-01-31	Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
CH642080A5 (fr)	1984-03-30	Antibiotiques du type beta-lactame, leur procede de production et medicament les contenant.
CH628900A5 (fr)	1982-03-31	Procede de preparation de thio-oximes derivees de cephalosporines et de penicillines.
LU82215A1 (fr)	1980-09-24	Procede et composes intermediaires pour la prouduction du 1,1-dioxyde d'acide penicillanique et de ses esters
EP0043756B1 (fr)	1984-05-09	1,2,4-Triazinylthiométhyl-3-céphèmes sulfoxydes, procédé de préparation et compositions pharmaceutiques en contenant
BE875054A (fr)	1979-07-16	Composes analogues aux cephalosporines
CH645903A5 (fr)	1984-10-31	Composes de la penicilline.
FR2465739A1 (fr)	1981-03-27	Cephalosporines, leurs procedes de preparation et compositions pharmaceutiques en contenant
CH634324A5 (fr)	1983-01-31	Acides amino-spiro(oxa(ou thia)cycloalcane-penam)-carboxyliques.
HU188825B (en)	1986-05-28	Process for production of derivatives of penicillaminebis /hydroxi-methil/ carbonates with antibacterial influence
BE821243A (fr)	1975-04-18	Derives de la penicilline
US4180658A (en)	1979-12-25	7[-2-Alkoxyamino(acetamido)]cephalosporin derivatives
FR2520362A1 (fr)	1983-07-29	Nouveaux composes de type b-lactame, y compris leurs sels formes avec des acides ou des bases acceptables en pharmacie, procedes pour produire ces composes, medicaments les contenant et leur utilisation pour combattre les maladies infectieuses
EP0311521B1 (fr)	1992-04-08	Dérivés des céphalosphorines à pharmacocinétique améliorée, procédé pour leur préparation, compositions pharmaceutiques les contenant et intermédiaire de synthèse
EP0269841B1 (fr)	1992-11-11	1-Hydroxyalkylxanthines, leurs procédés de préparation et médicament les contenant
FR2522663A1 (fr)	1983-09-09	Nouveaux alcaloides ergopeptidiques, leur preparation et leur utilisation comme medicaments