LU103079B1

LU103079B1 - IMMUNIZATION AGAINST VIRAL INFECTIONS DISEASE(S)

Info

Publication number: LU103079B1
Application number: LU103079A
Authority: LU
Inventors: Wolfgang Schönharting; Mari Carmen Martos Contreras; Meik Kunz
Original assignee: PMCR GmbH
Priority date: 2023-02-28
Filing date: 2023-02-28
Publication date: 2024-08-28

Abstract

The present invention relates to a pharmaceutical composition for use in the treatment or prophylaxis of at least one viral infectious disease, comprising at least one antigen polypeptide comprising at least one HLA peptide corresponding to MHC class I complexes, wherein the HLA antigen peptides are coronavirus exclusive and are directed against at least one MHC class I complex including combinations thereof; a pharmaceutical composition, a kit (or parts thereof), a method for determining a class I HLA peptide and/or antigen polypeptide, a method for preparing a formulation according to the invention, and the use of a formulation according to the invention for the preparation of a pharmaceutical composition for the treatment of at least one viral infectious disease.The present invention relates to a pharmaceutical composition for use in the treatment or prophylaxis of at least one viral infectious disease, comprising at least one antigen polypeptide comprising at least one HLA peptide corresponding to MHC class I complexes, wherein the HLA antigen peptides are coronavirus exclusive and are directed against at least one MHC class I complex including combinations thereof; a pharmaceutical composition, a kit (or parts thereof), a method for determining a class I HLA peptide and/or antigen polypeptide, a method for preparing a formulation according to the invention, and the use of a formulation according to the invention for the preparation of a pharmaceutical composition for the treatment of at least one viral infectious disease.

Description

This disclosure relates to the field of amino acids to prevent or treat viral infections). In particularly to a combination agent/composition comprising of at isast one, more particularly at mast two and most particularly up to 12 different synthelic peptide complexes (antigen immunization against viral infectious diseases while avoiding infection-enhancing antibodies,This disclosure relates to the field of amino acids to prevent or treat viral infections). In particularly to a combination agent/composition comprising at isast one, more particularly at mast two and most particularly up to 12 different synthetic peptide complexes (antigen immunization against viral infectious diseases while avoiding infection-enhancing antibodies,

HLA antigen peptide corresponding fo the MMC class | Complexes and/or antigen polypeptide for use in the pharmaceutical composition and s method for preparing a pharmaceuticalHLA antigen peptide corresponding to the MMC class | Complexes and/or antigen polypeptide for use in the pharmaceutical composition and method for preparing a pharmaceutical

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FMCR GmbHFMCR GmbH

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PCR GmbHPCR GmbH

PRIC-GCO7-P-LU 28.02 2023 Luxemburgische PalentanmaldungPRIC-GCO7-P-LU 28.02 2023 Luxembourg Palentan declaration

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PMC-GO07-P-LU AO ELPMC-GO07-P-LU AO EL

PMC-CG07-P-LU 2 prevention and/or treatment of such viral infectious diseases, which include the administrationPMC-CG07-P-LU 2 prevention and/or treatment of such viral infectious diseases, which include the administration

À severe shortcoming of known combination immunization strategies is that individually usable 5 vaccines are combined in a combination vaccination, withou! modifying the vaccines for uss in this application. In some embodiments of the invention, À may provide synthetic landem viral infectious diseases, again matching different HLA À and HUA B antigen peptides and withÀ severe shortcoming of known combination immunization strategies is that individually usable 5 vaccines are combined in a combination vaccination, without you! modifying the vaccines for uss in this application. In some embodiments of the invention, À may provide synthetic landem viral infectious diseases, again matching different HLA À and HUA B antigen peptides and with

Solution

To overcome the technical problems of the prior art, a preferred embodiment of the present invention comprises of pharmacologically active agents {so called “antigen polypeptide” or “antigen polypeptide sequences”, pharmaceutical compositions and/or methods which haveTo overcome the technical problems of the prior art, a preferred embodiment of the present invention comprises pharmacologically active agents {so called “antigen polypeptide” or “antigen polypeptide sequences”, pharmaceutical compositions and/or methods which have

À mors preferred embdodiment of the present invention is to provide therapeuticaily active synthetic polypeptides matching HLA antigen peptides that may be used as phanmacologically anantys veasnantivahs and fn arovicda alhamsmacandiceal say SS HANNS Ey NIS NEN osme Fong deThe preferred embodiment of the present invention is to provide therapeutically active synthetic polypeptides matching HLA antigen peptides that may be used as phanmacologically anantys veasnantivahs and fn arovicda alhamsmacandiceal say SS HANNS Ey NIS NEN osme Fong de

SU FUSS, TESDETUVSIY, SIE 10 Provide pNarMmacaulical Compasiiong fomaming same, Toi me prevention and/or therapeutic treatment of such infections and disorders involving the administration and/or use of such therapeutically active polypentidss matching HLA antigen therapeutic use in warm-blooded animals, more particularly in mammals and most particularly in humans.SU FUSS, TESDETUVSIY, SIE 10 Provide pNarMmacaulical Compasiiong fomaming same, Toi me prevention and/or therapeutic treatment of such infections and disorders involving the administration and/or use of such therapeutically active polypentidss matching HLA antigen therapeutic use in warm-blooded animals, more particularly in mammals and most particularly in humans.

According io the invention, these objections are soived Dy à pharmaceutical composition for an use in the tharnnautis andior oroanhviactio fraatmant of at least ane viral faction comnrisineAccording to the invention, these objections are soived Dy à pharmaceutical composition for a use in the tharnnautis andior oroanhviactio fraatmant of at least ane viral faction comnrisine

Sid USE IT INS INSrapsulic anion propnmyiiaciic aaimait OT EL 18881 ONS viral IHECLUON, Comprising a pharmacologically effective amount of at least ons, proferably at least 7, more preferably 3,Sid USE IT INS INSrapsulic anion propnmyiiaciic aaimait OT EL 18881 ONS viral IHECLUON, Comprising a pharmacologically effective amount of at least ons, proferably at least 7, more preferably 3,

FMCR GmbHFMCR GmbH

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LG A infection with preferably at least two different viral infectious diseases, mors preferably against three different viral infectious diseases and io prevent severe disease progression in the event that an infection has occurred, in addition to B-cel-mediated antibody generation, the main focus of the current invention is on the T-cell response. Preferably, administration of the three of the viral infectious diseases the combination composition Is intended 10 immunize against, with the proportion of non-neulralizing antibodies preferably being less than 10%, imitation to any explanation, mechanism of action or hypothesis in the present invention, {aiso referred to as synthetic antigen polypeptides) of the Invention have been determined based on their ability and inferaction with specific virus structures, These structures of amine acid seduences of the invention are fas described halow) ice SL TLE WE LG Ghana CS LEW MS GT INGA WISIN 1 diseases can be archived with only one preparation consisting of synthetic polypeptides matching different paris of the virus epitopes, therefore radusing he amounis of injections vaccinations {which are made up of multiple individual vaccines) in one embodiment, HLA antigen peptides in accordance with the present invention are corresponding to MMC class ! and/or | complexes. in one embodiment, HLA antigen peptides in accordance with the present invention arg corresponding to MHC class | and/or H complexes, particulary for the immunization and/orLG A infection with preferably at least two different viral infectious diseases, mors preferably against three different viral infectious diseases and io prevent severe disease progression in the event that an infection has occurred, in addition to B-cel-mediated antibody generation, the main focus of the current invention is on the T-cell response. Preferably, administration of the three of the viral infectious diseases the combination composition Is intended 10 immunize against, with the proportion of non-neuralizing antibodies preferably being less than 10%, imitation to any explanation, mechanism of action or hypothesis in the present invention, {aiso referred to as synthetic antigen polypeptides) of the Invention have been determined based on their ability and inferaction with specific virus structures, These structures of amine acid seduences of the invention are fas described halow) ice SL TLE WE LG Ghana CS LEW MS GT INGA WISIN 1 diseases can be archived with only one preparation consisting of synthetic polypeptides matching different paris of the virus epitopes, therefore radusing he amounis of injections vaccinations {which are made up of multiple individual vaccines) in one embodiment, HLA antigen peptides in accordance with the present invention are corresponding to MMC class! and/or | complexes. in one embodiment, HLA antigen peptides in accordance with the present invention arg corresponding to MHC class | and/or H complexes, particularly for the immunization and/or

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TOU IHS 10 OCCUT, ING amiga buraische Patentanmelduna m ATS Ma LE Lukemburgische Patentanmeld ANGTOU IHS 10 OCCUT, ING amiga Buraan patent applicationuna m ATS Ma LE Lukemburgian patent application ANG

PMOR GmbH SA AN SANS LUXE TOUTES CTPMOR GmbH SA AN SANS LUXE TOUTES CT

PILE SD 28.02 2023 MX 3PILE SD 28.02 2023 MX 3

DRAOONOT MI TIDRAOONOT MI TI

PRIC-GCO7-P-LU of so-called auxiliary proteins, Thess include CD4 and CDS (CD = "Cluster of Differentiation’,PRIC-GCO7-P-LU of so-called auxiliary proteins, Thess include CD4 and CDS (CD = “Cluster of Differentiation’,

T coll iymphocoyles contain the CD4+ and the CDS+ positive T cells, T cells that carry the C4 cells account for 27-57% of lymphocytes, or approximately 310-1570 calis/yl, The group ofT coll iymphocoyles contain the CD4+ and the CDS+ positive T cells, T cells that carry the C4 cells account for 27-57% of lymphocytes, or approximately 310-1570 calis/yl, The group of

Killing the body's own cells that are infected by pathogens, such as viruses. make up the critical component of the adaptive immune system, While T cells are involved in {and are responsible for the formation of antibodies). 1 has been shown In experiments that preferably more than 100 ua and particularly preferably more than 500 ug are quite oreferredKilling the body's own cells that are infected by pathogens, such as viruses. make up the critical component of the adaptive immune system, while T cells are involved in {and are responsible for the formation of antibodies). 1 has been shown In experiments that preferably more than 100 ug and particularly preferably more than 500 ug are quite oreferred

MISIGTQANY DISC War TUL NU GI Mai UGA EN RTI aliany TTC LE QUAY NY TS URE pisces, = 7,200 ug are contained in the pharmaceutical composition (per vial, 1 15 highly above, which, when the composition is applied {© a patient, are capable of intensifying theMISIGTQANY DISC War TUL NU GI Mai UGA EN RTI aliany TTC LE QUAY NY TS URE pisces, = 7,200 ug are contained in the pharmaceutical composition (per vial, 1 15 highly above, which, when the composition is applied {© a patient, are capable of intensifying the

Comprehensive of a balanced Th{Th2 based robust immune response, CpG (sligonuciectideComprehensive of a balanced Th{Th2 based robust immune response, CpG (sligonuciectide

The letter C stands for the nucleotide oytosine, the 5 for phosphate and the G for the nucleatids possibilities for using these compounds, for example, to improve the efficacy of vaccines. In vaccination schedule from three (ail other approved HEV vaccines) fo two vaccinations, In pharmaceutical composition of up to 12 amino acid sequences used in accordance with theThe letter C stands for the nucleotide oytosine, the 5 for phosphate and the G for the nucleatids possibilities for using these compounds, for example, to improve the efficacy of vaccines. In vaccination schedule from three (ail other approved HEV vaccines) fo two vaccinations, In pharmaceutical composition of up to 12 amino acid sequences used in accordance with the

FMCR GmbHFMCR GmbH

PRIC-GCO7-P-LU 28.02 2023 Luxemburgische Palentanmaldung srPRIC-GCO7-P-LU 28.02 2023 Luxembourg Palentanmaldung sr

LU103079 & vaccination mare effective against new mutations.LU103079 & vaccination mare effective against new mutations.

Furthermore, in an aspect of the current invention, 1 is an outstanding achievement of the inventors fo have discovered à pharmaceutical composition of up fo 12 amino acid sequences parts of à selection of at least wo viral infectious diseases by comparing them to differant mutants, relaisd viruses, wildhtypes and other related viruses, thus enabling a vaccination more effective against new mutations. in one embodiment of Ihe invention relating to coronaviruses, the spike glycoprotein consists of trimers that form large structures, referred to as spikes or pepiomers, which project from theFurthermore, in an aspect of the current invention, 1 is an outstanding achievement of the inventors fo have discovered à pharmaceutical composition of up to 12 amino acid sequences parts of à selection of at least wo viral infectious diseases by comparing them to different mutants, relayd viruses, wildtypes and other related viruses, thus enabling a vaccination more effective against new mutations. in one embodiment of Ihe invention relating to coronaviruses, the spike glycoprotein consists of trimers that form large structures, referred to as spikes or pepiomers, which project from the

Si subunit is responsible for the interaction with the cells receptor proteins and docks to the angiotensin canvearling anzuma 2 {ACES mambrans nrotem The 82 renan cansist of thaSi subunit is responsible for the interaction with the cells receptor proteins and docks to the angiotensin canvearling anma 2 {ACES mambrans nrotem The 82 renan cansist of tha

CHAITIN LAVIN SUEY ING 6 IMS) Eni ahs Jalon. ad Qa TORRE LAMELLEN 165 of hydrophobic amino acids. The SE region Is more sonsanad IN Coronavinisss compared io the ST region, In a preferred embodiment of the invention, al least one amino acid sequence is selected to target the 82 region of the coronavirus specifically, since for effective entry of aCHAITIN LAVIN SUEY ING 6 IMS) Eni ahs Jalon. ad Qa TORRE LAMELLEN 165 of hydrophobic amino acids. The SE region Is more sonsanad IN Coronavinisss compared io the ST region, In a preferred embodiment of the invention, at least one amino acid sequence is selected to target the 82 region of the coronavirus specifically, since for effective entry of a

D) fusion of the host cell and virlon membranes primed by the searing 2 transmembraneD) fusion of the host cell and virlon membranes primed by the searing 2 transmembrane

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In à alternative embodiment of the present invention at least one of the antigen polypeptide sequences of the pharmaceutical composition comprises epitopes of the BARS-CoV-2 Spike sequences of the pharmaceutical composition comprises spitopes of the of the SE membrane fusion subunit of the Spike protein specifically rather than the 81 receptor binding domain (RED). In this respect, blocking the SZ fusion protein by antibodies is expected io mechanism. In contrast to the ST subunit, the Se subunit is highly conserved and shows only & low Mutation rate. Advantageously, the use of 32 specific apitopes results in improvedIn à alternative embodiment of the present invention at least one of the antigen polypeptide sequences of the pharmaceutical composition comprises epitopes of the BARS-CoV-2 Spike sequences of the pharmaceutical composition comprises epitopes of the of the SE membrane fusion subunit of the Spike protein specifically rather than the 81 receptor binding domain (RED). In this respect, blocking the SZ fusion protein by antibodies is expected io mechanism. In contrast to the ST subunit, the Se subunit is highly conserved and shows only & low Mutation rate. Advantageously, the use of 32 specific apitopes results in improved

FMCR GmbHFMCR GmbH

PMC-GO07-P-LU 23.02 2023 Luxemburgische PalentanmaldungPMC-GO07-P-LU 23.02 2023 Luxembourg Palentanmaldung

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DA + 22 AY IN espe ive nee iese ban Fedora aaa bet pet © ay LU 23.02 2023 LUXS IMOUGISONS FalantanmaiqungDA + 22 AY IN espe ive nee iese ban Fedora aaa bet pet © ay LU 23.02 2023 LUXS IMOUGISONS Falantanmaiqung

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MELLE À, 2 mechanism is supported by the observation that antigens that bind more strongly to the ädiuvant cause a stronger immune response, In particular, alum-dependent T cell antibody-based HTMUNE response, Alum can further promote antigen uptake in antigen- (NS SPOPGPOUS POS YSLGLSFTRTTF RQ 'MELLE À, 2 mechanism is supported by the observation that antigens that bind more strongly to the aediuvant cause a stronger immune response, In particular, alum-dependent T cell antibody-based HTMUNE response, Alum can further promote antigen uptake in antigen- (NS SPOPGPOUS POS YSLGLSFTRTTF RQ'

HSE retain OID OE Thie water. soluble adjuvant induces potent responses from CDS and CD4 positive T cells. used in a vanely of market approved human vaccines, They can lead to an improved and responses. MFSS is currently used as an adivvant in the United States Canada and Europe.HSE retain OID OE Thie water. Soluble adjuvant induces potent responses from CDS and CD4 positive T cells. used in a variety of market approved human vaccines, They can lead to an improved and responses. MFSS is currently used as an adivvant in the United States Canada and Europe.

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A SANS EN Te Sanieren for beiter physiological compatibility the pH of the pharmaceutical composition is considered, or only slightly acidic. In à preferred embodiment of the present invention single peptides have 3 A A ans mnet nrofarras of 2 & maximum sxcess of acidic amino acids of 5, more preferred of 4, and most preferred of 3. ï Arne: ANA avrage le arabe of 8, and most preferred {8 an excess of § basic amino acids, Amino acid excess is hsreby protein contains the fusion peptide, a stretch of mainly hydrophobic amino acids, thus in aA SANS EN Te Sanieren for beiter physiological compatibility the pH of the pharmaceutical composition is considered, or only slightly acidic. In a preferred embodiment of the present invention single peptides have 3 A A ans mnet nrofarras of 2 & maximum sxcess of acidic amino acids of 5, more preferred of 4, and most preferred of 3. ï Arne: ANA avrage le arabe of 8, and most preferred {8 an excess of § basic amino acids, Amino acid excess is hsreby protein contains the fusion peptide, a stretch of mainly hydrophobic amino acids, thus in a

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SEQ ID NOs: 38-58) is mainly compromised of hydrophobic amino acids, preferably the share {%-80% of the total amine acids of the sequence bearing hydrophobic aming groups, moreSEQ ID NOs: 38-58) is mainly compromised of hydrophobic amino acids, preferably the share {%-80% of the total amine acids of the sequence bearing hydrophobic amino groups, more

Bc aon 28.02 2023 Luxemburgische PalentanmeldungBc aon 28.02 2023 Luxembourg Palent Declaration

PMC-0007-P-LU 28.02 2023 LuxemburgPMC-0007-P-LU 28.02 2023 Luxembourg

XX

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N iment, the CO-1ermminus angio NASEN OF NS SINGT. DOIVDSIMIUS in à referred embodiment in TAT IT RNIN CLS GE PRE II IS x : NM 3 ¥i $N iment, the CO-1ermminus angio NASEN OF NS SINGT. DOIVDSIMIUS in à referred embodiment in TAT IT RNIN CLS GE PRE II IS x: NM 3 ¥i $

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CARDING S'OUDS NOT OMV HNCIGSSS TEEN Sao X XCARDING S'OUDS NOT OMV HNCIGSSS TEEN Sao X

AREA WIIG TM Nery + affinitionAREA WIIG TM Nery + affinition

DNS. ~ $ m * 3 à AN AN a ATDNS. ~ $ m * 3 à AN AN a AT

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A Ye da ie prefarred ambodiment one of the aforementioned amino acing iA Ye da ie prefarred ambodiment one of the aforementioned amino acing i

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Heron SOON INES ONE QF MONE MLA-A ST HWE X : : is RE - Damien HEwvaminsias far ans hear ati x Te tin Outarming! andar Altarminat nosition Examnies for anchor amino by an anchor amine acid in G4 TNH SCHOTT IN-TSTTTHITSN MASINI LOA € €Heron SOON INES ONE QF MONE MLA-A ST HWE X : : is RE - Damien HEwvaminsias far ans hear ati x Te tin Outarming! andar Altarminat nosition Examnies for anchor amino by an anchor amine acid in G4 TNH SCHOTT IN-TSTTTHITSN MASINI LOA € €

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TAU 23.02 2023 aTAU 23.02 2023 a

PMC-GO07-P-LU AOL AV ED 4PMC-GO07-P-LU AOL AV ED 4

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LU103079 an amino acid sequence located within a region of at least one virus related to a viral infectious disease, wherein the amino acid sequence of the first MLAA and/orLU103079 an amino acid sequence located within a region of at least one virus related to a viral infectious disease, wherein the amino acid sequence of the first MLAA and/or

HLA-S antigen peptide differs from the amine acld sequence of the second or the antigen polypeptide according io the invention can be used © “target” a species (such as only the spike SI domain, 32 domain, nucisocapsid profein, and'or {i} each ons of the HLA-A and/or HLA-B antigen peptide located within the lande an amino acid sequence located within à region of a different virus related to a viralHLA-S antigen peptide differs from the amine acld sequence of the second or the antigen polypeptide according to the invention can be used © “target” a species (such as only the spike SI domain, 32 domain, nucisocapsid profein, and'or { i} each ons of the HLA-A and/or HLA-B antigen peptide located within the lande an amino acid sequence located within a region of a different virus related to a viral

INTECHOUS diseases, wherein the amine acid sequence ofthe first HLA-A and/or HLAINTECHOUS diseases, wherein the amine acid sequence of the first HLA-A and/or HLA

BE antigen peptide differs from the amine acid sequence of the second or the other int & first virus, especially first virus sub-spacies and the second or the other HLA-A andor HLA-R antigen nantide si corrasnonds to and “tarost”’ a region in a secondBE antigen peptide differs from the amine acid sequence of the second or the other int & first virus, especially first virus sub-spacies and the second or the other HLA-A andor HLA-R antigen nantide si corrasnonds to and “tarost”' a region in a second

SHEA PARTS SIG RGAE OF LATE CARA ING LL CHERE CON VOS Si TERT NT ST OeSHEA PARTS SIG RGAE OF LATE CARA ING LL CHERE CON VOS Si TERT NT ST Oe

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VIUS, ÉSSOGIQRY SORA VITUS SUIS SÇOGISS, AS à FOSUN, Ng TONQON SPEISEN invention can be used not only for the treatment of a specific/single viral infectious disease, especially spedifioisingle virus Sub-Species, bul moreover for the use in prophviactic treatment of à family-spanning, preferably at least subfamily-spanning, infectious disease,VIUS, ÉSSOGIQRY SORA VITUS SUIS SÇOGISS, AS à FOSUN, Ng TONQON SPEISEN invention can be used not only for the treatment of a specific/single viral infectious disease, especially spedifioisingle virus Sub-Species, bul moreover for the use in prophviactic treatment of à family spanning, preferably at least subfamily spanning, infectious disease,

SOSO

CE sach one of the HLA-A and/or HLA-B antigen peptide located within the tandem antigen polypaplide or the overlapping tandam antigen pobypaplide corresponds io 5 antigen peptide differs from the amino acid sequence of the second or the otherCE sach one of the HLA-A and/or HLA-B antigen peptide located within the tandem antigen polypaplide or the overlapping tandam antigen pobypaplide corresponds io 5 antigen peptide differs from the amino acid sequence of the second or the other

FMCE GmbHFMCE GmbH

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LU103079 first MLA-A and/or HLACE antigen peptide corresponds to and “target!” a first region corresponds to and Target” a region in à second virus, especially TIRE second virus more preferably from another viral kingdom, especially from another viral phyla, such as another subphyia, More especially preferably from another virai Class, praferably from another family, such as a subfamily, Most especially preferably from from another species, As a result, the tandem antigen polypeptide, or the only for the treatment of à specific/single viral infectious disease, especially specific/single virus sub-spagies, bul moreover for the use in the broad-spectrum immunization, preferably for use in the therapeutic or prophylactic treatment of at least two different, preferably not closely related viral infectious diseases. in a preferred embodiment of the current invention, the antigen polypeptides of (Hi) correspond ip the apilopes of at least two different viral diseases, preferably from different species,LU103079 first MLA-A and/or HLACE antigen peptide corresponds to and “target!” a first region corresponds to and Target” a region in à second virus, especially TIRE second virus more preferably from another viral kingdom, especially from another viral phyla, such as another subphyia, More especially preferably from another virai Class, preferably from another family, such as a subfamily, Most especially preferably from another species, As a result, the tandem antigen polypeptide, or the only for the treatment of a specific/single viral infectious disease, especially specific/single virus sub-spagies, bul moreover for the use in the broad-spectrum immunization, preferably for use in the therapeutic or prophylactic treatment of at least two different, preferably not closely related viral infectious diseases. in a preferred embodiment of the current invention, the antigen polypeptides of (Hi) correspond ip the apilopes of at least two different viral diseases, preferably from different species,

In a more preferred embodiment of the current invention, the antigen polvpsplides of (i) praferably at isast four different viral diseases, Most especially preferably up to five viruses viral eenIn a more preferred embodiment of the current invention, the antigen polvpsplides of (i) preferably at isast four different viral diseases, most especially preferably up to five viruses viral een

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In an alternative embodiment of the invention related lo à coronavirus, a tandem antigen polypeptide as defined in Rem (0 or an overlapping tandem antigen polypeptide as defined inIn an alternative embodiment of the invention related to coronavirus, a tandem antigen polypeptide as defined in Rem (0 or an overlapping tandem antigen polypeptide as defined in

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PRIC-GCO7-P-LU 28.02 2023 Luxemburgische Palentanmaldung xPRIC-GCO7-P-LU 28.02 2023 Luxembourg Palentan declaration x

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LU103079 other HLA-A and/or MLAB antigen peptides) of the antigen polypeptide, for coronavirus, especially a specific/single region of a virus sub-speacias (such as only the spike 81 domain, 82 domain, nucleocapsid protein, envelope profsin orLU103079 other HLA-A and/or MLAB antigen peptides) of the antigen polypeptide, for coronavirus, especially a specific/single region of a virus sub-speacias (such as only the spike 81 domain, 82 domain, nucleocapsid protein, envelope profsin or

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ORFIab polyprotaind, but moreover for the use in broad largeting, preferably for and/or {ii} each ons of the HLA-A and/or HLA-B antigen peptide located within the tandem antigen polypeptide or the overlapoing landem antigen polypeptide corresponds to within the spike 31 domain, 82 domain, nucleocapsid protein, envelope protein and/or ORFTab polyprotein, wherein the amino acid sequence of the first HLA-A or the other HLA-A and/or HLA-5 antigen peptida(s) of the antigen polypepide in a first region in à first coronavirus, especially first virus sub-species (such SARS-ORFIab polyprotaind, but moreover for the use in broad sizing, preferably for and/or {ii} each ons of the HLA-A and/or HLA-B antigen peptide located within the tandem antigen polypeptide or the overlapping landem antigen polypeptide corresponds to within the spike 31 domain, 82 domain, nucleocapsid protein, envelope protein and/or ORFTab polyprotein, wherein the amino acid sequence of the first HLA-A or the other HLA-A and/or HLA-5 antigen peptida(s) of the antigen polypepide in a first region in à first coronavirus, especially first virus sub-species (such SARS-

B antigen peptide(s} corresponds fa and Target” a region in à Second coronavirus, or the overlapping tandem antigen polypeptide according to the invention can be used not only for the dresiment of à specific/single coronavirus, especiallyB antigen peptide(s} corresponds fa and Target” a region in à Second coronavirus, or the overlapping tandem antigen polypeptide according to the invention can be used not only for the desiment of à specific/single coronavirus, especially

CoV), bul moreover for the use in the broad-spectrum immunization, preferably forCoV), bul moreover for the use in the broad-spectrum immunization, preferably for

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PCR GmbHPCR GmbH

PMC-0007-P-LU 28.02 2023 Luxemburgische PalentanmeldungPMC-0007-P-LU 28.02 2023 Luxembourg Palent Application

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S aa 4e ih = Sta SANTONIO TS in 1 + À antigen nantides corresnn: inc to ; i Sof tha current invention are mi A anugen Dentides SIT KESSEL a, À nraterrad emhneiimant ft & SLITS INVEITTION ars mus : 8S aa 4e ih = Sta SANTONIO TS in 1 + À antigen nantides corresnn: inc to ; i Sof tha current invention are mi A anugen Dentides SIT KESSEL a, À nraterrad emhneiimant ft & SLITS INVEITTION ars mus: 8

A DI'STSITSO SNIDOSIMONT OT INS gun a ; i : En fire infantioninie $ } anhnviavia of à Virus infections 5, ir +4 Am ses oF Aramis LT à VEUS FRGCIOUS i i «in particular for use in the raatmeant Qf Di QHTVIAXIS LID WHS NSA DI'STSITSO SNIDOSIMONT OT INS gun a ; i : En fire infantioninie $ } anhnviavia of à Virus infections 5, ir +4 Am ses oF Aramis LT à VEUS FRGCIOUS i i «in particular for use in the raatmeant Qf Di QHTVIAXIS LID WHS NS

AO sings | comniavas in nar ioular for use in the ssimen ehAO sings | comniavas in nar ioular for use in the ssimen eh

RNG Ciass | COMDISKSS, El RPC adie a ) . € ca 31 - AT SIMSRNG Ciass | COMDISKSS, El RPC adie a ) . € approx. 31 - AT SIMS

Torey sive ps fav containingTorey sive ps fav containing

Flaw id 3 FN ee ae VAN D VITUS Tamiv ES fi male but not limited to Lrnomyxovingag, a virus FETT >Flaw id 3 FN ee ae VAN D VITUS Tamiv ES fi male but not limited to Lrnomyxovingag, a virus FETT >

HsSase OP axampig IN NREL I Srna ; discsase TOU EXAamMDiE DUT OT NM 3HsSase OP axampig IN NREL I Srna ; discsase TOU EXAamMDiE DUT OT NM 3

N SXEN MIGN SXEN MIG

MCE GmbH Luxemburaische PalentanmeldunaMCE GmbH Luxembourg Patent Registration Office

Stora 28.02 2023 LUXEMOUTEISCHS Faenianimaiqung i i LANL AEDStora 02/28/2023 LUXEMOUTEISCHS Faenianimaiqung i i LANL AED

DRACO DL Li 2DRACO DL Li 2

PMO-OG07-P-LUPMO-OG07-P-LU

Yhaaatavirus, and Quaraniavirus (necatve-sense RNA viruses) and/ar sallavirus from thaYhaaatavirus, and Quaraniavirus (necatve-sense RNA viruses) and/ar sallavirus from tha

VS WI AES, CHE AIMS SHRI LFS CIO MGI VC AN tow NENA WH MARS SIL MURS (HIS LS family of Reoviridas with double stranded RNA viruses), and/or tick-borne encephalitis virus papillomavirus (HPV, from the Pagilomaviridas family of DNA viruses), in 8 person or group of persons who has contracted or is at risk of contracting such a aforementioned viral infectious dissase and/or for a pharmaceutical composition according to the invention consisting of antigen polypeptides. class | complexes, in particular for use in the treatment or prophyviaxis of a coronavirusVS WI AES, CHE AIMS SHRI LFS CIO MGI VC AN tow NENA WH MARS SIL MURS (HIS LS family of Reoviridas with double stranded RNA viruses), and/or tick-borne encephalitis virus papillomavirus (HPV, from the Pagilomaviridas family of DNA viruses ), in 8 person or group of persons who has contracted or is at risk of contracting such a mentioned viral infectious dissase and/or for a pharmaceutical composition according to the invention consisting of antigen polypeptides. class | complexes, in particular for use in the treatment or prophyviaxis of a coronavirus

Composition according to the Invention, wherein the HLA-A antigen peptides or HLA-B antigen in Table 1-8 or which have at least one mulation, preferably an amino acid substitution, with fespect io one of these amine sold sequences,Composition according to the Invention, wherein the HLA-A antigen peptides or HLA-B antigen in Table 1-8 or which have at least one mulation, preferably an amino acid substitution, with certainty one of these amine sold sequences,

Particularly preferred herein is the use of the foregoing HUA antigen peptides and/or antigen polypeptides for use in a method of treating at least one viral infectious disease in a patient or group of patients having at least one identical HLA allele, the method comprising administering/apniving a treatment regimen to a aubiect or group of subjects such that aParticularly preferred is the use of the foregoing HUA antigen peptides and/or antigen polypeptides for use in a method of treating at least one viral infectious disease in a patient or group of patients having at least one identical HLA allele, the method comprising administering/ giving a treatment regimen to an aubiect or group of subjects such as

SAI ISIS ARERR FINE © BSUS I%HENEN MS 8 QUASGLL VE AERA WI SURES lala Lidl SR pharmacologicaily effective amount comprises at eas! one of the foregoing HLA antigen paniides,SAI ISIS ARERR FINE © BSUS I%HENEN MS 8 QUASGLL VE AERA WI SURES lala Lidl SR pharmacologicaily effective amount comprises at eas! one of the foregoing HLA antigen paniides,

DN Another aspect of the currant invention is the use ofthe forscoino HLA antigen nantides andor ad AEPRANT SoTL LINE GLI IVS RRA Is D LSE OF UNS TON TANS ILA CR UNE PO SUR STI IRIS LS à trsaiment regimen io a Subject or group of subjects such that a pharmacotogicaily effective as defined herein is for use in therapeutic or prophylactic treatment of à coronavirus infectious dissase in a Hving Subject, wherein the therapeutic or prophylactic treatment comprisesDN Another aspect of the current invention is the use of the forscoino HLA antigen nantides andor ad AEPRANT SoTL LINE GLI IVS RRA Is D LSE OF UNS TON TANS ILA CR UNE PO SUR STI IRIS LS à trsaiment regimen io a Subject or group of subjects such that a pharmacotogicaily effective as defined in is for use in therapeutic or prophylactic treatment of à coronavirus infectious dissase in a Hving Subject, wherein the therapeutic or prophylactic treatment comprises

FMCE GmbHFMCE GmbH

PMC-0C07-P-LU 28.02 2023 Luxemburgische Palentanmeldung aPMC-0C07-P-LU 28.02 2023 Luxembourg Palent Application a

LU103079 administering an effective amount of the pharmaceutical composition to à subject and/or group of subjects. in one atemative embodiment of the invention related to coronaviruses, the HLAA and/orLU103079 administering an effective amount of the pharmaceutical composition to à subject and/or group of subjects. in one breathative embodiment of the invention related to coronaviruses, the HLAA and/or

HLA-S antigen pepüde(s) corresponding fo MMO class | complexes of the at least one antigen polypeptides, preferably as used in the pharmaceutical composition, is/are an amine acid sequence Seiscisd from the group consisting of SEQ ID NO: 1 — 37, 55 — 75, i 3 iment the antigen nolvnantide(s\ nreferably as used in the npharmaceutisalHLA-S antigen pepüde(s) corresponding fo MMO class | Complexes of the at least one antigen polypeptides, preferably as used in the pharmaceutical composition, is/are an amine acid sequence Seiscisd from the group consisting of SEQ ID NO: 1 - 37, 55 - 75, and 3 within the antigen nolvnantide (s \nreferably as used in the npharmaceutisal

HT ONE ambodimen, 016 antigen DONDEDUCE(S), DIOTSfADV a8 used mn the pnam composition, Is/are an amino acid sequence selected from the group consisting of SEQ ID 1HT ONE ambodimen, 016 antigen DONDEDUCE(S), DIOTSfADV a8 used mn the pnam composition, Is/are an amino acid sequence selected from the group consisting of SEQ ID 1

In one embodiment, the pharmaceutical composition further comprises al lsast one amino acidIn one embodiment, the pharmaceutical composition further comprises all one amino acid

SEQUENCES cumprising or consisting of an HLA-A or HLA-B antigen peptide, wherein the HLA 165 the virus presented on the surface of the virus, More preferably being part of the viral epitope. sequence as defined herein, more preferably, the amine acid sequence is Ssiscisd from theSEQUENCES cumprising or consisting of an HLA-A or HLA-B antigen peptide, wherein the HLA 165 the virus presented on the surface of the virus, more preferably being part of the viral epitope. sequence as defined in, more preferably, the amine acid sequence is Ssiscisd from the

An "HLA-A antigen peptide corresponding to MHC class | complexes” is defined herein as an sequence of the invention” (as defined herein} comprising: consisting of 7 to 10 amino acids, and Most preferably consisting of 8 or D amine acids 28 to a protein encoding RNA sequence in the genome of a vival infectious disease, according io the invention at à concentration, as defined above, of at least 190 yg and concentration of al least 500 ug relative to the volume of the pharmaceuticalAn "HLA-A antigen peptide corresponding to MHC class | complexes” is defined in as a sequence of the invention” (as defined in} comprising: consisting of 7 to 10 amino acids, and Most preferably consisting of 8 or D amine acids 28 to a protein encoding RNA sequence in the genome of a vivo infectious disease, according to the invention at à concentration, as defined above, of at least 190 yg and concentration of at least 500 ug relative to the volume of the pharmaceutical

Draft by. the HLA-A antiosn peotides are selected as defined above under point (iiDraft by. the HLA-A antioxidant peotides are selected as defined above under point (ii

Preferably, the HLA-A antigen peptides are selected as defined above under point (5)Preferably, the HLA-A antigen peptides are selected as defined above under point (5)

AGAG

Assnreine TA a narfisaderks arafarran amkanimant an SRE ALA antisan santa” ie rnrofarranAssnreine TA a narfisaderks arafarran amkanimant an SRE ALA antisan santa” ie rnrofarran

ACCOTGHIQ 10 à daniCliiany OSTSEITE emnaaimeant, an MLA- A angen DSDS , IS pramsiveq, somnrising the following scaffold sequence:ACCOTGHIQ 10 à daniCliiany OSTSEITE emnaaiimeant, an MLA- A angen DSDS , IS pramsiveq, somnrising the following scaffold sequence:

LASHER RATIO ELE WEG FLOAT H I SAGE ENT ADAM ESLASHER RATIO ELE AWAY FLOAT H I SAGE ENT ADAM IT

Fa) AR AHR seien sans Same Ar canaeioting af an amine AH van ande aolastas (A} A SD ala sequence SOMPNSG OF CONSISENS OF af AIS RE SOQUONGE SORGENFa) AR AHR sei sans Same Ar canaeioting af an amine AH van ande aolastas (A} A SD ala sequence SOMPNSG OF CONSISENS OF af AIS RE SOQUONGE SORGEN

Seven wns en APN EE a ae ui CNET ES AN Aa SHOES ON CS SD ES ON CIS CNE CNRS ER CCS froum tha ANTOUD oonsisting of SEM ID NOg 1 37 9 18 18.18 717 57 SQ.A1 SESeven wns en APN EE a ae ui CNET ES AN Aa SHOES ON CS SD ES ON CIS CNE CNRS ER CCS froum tha ANTOUD oonsisting of SEM ID NOg 1 37 9 18 18.18 717 57 SQ.A1 SE

HOM TS GTOUD CONSISUNG OF DEL IL INST, 3-4, UW, 10, 19-10, EEE, df, £801, 3a = AE ba en ges ie aise ue dique Cao Ai = car Conon a paris es cv a om pg Seat . En ses Jaen a = 2A & whaerain whan ha Sins 200 Saniancg Samaricas an aisremantinnes amin > ad, 30, WSS WHEN Ng amid 800 SEQUENTS CONDISSS an Ai0fSMENtioNed aming aye ene a din es an EN a ry CEN ANE NE oe nye pue dean oem Be Ÿ Heath eau Present aa bo Fly od ened août saauancs the amino acid saqduance arafarahlı further comprises un fa hut notHOM TS GTOUD CONSISUNG OF DEL IL INST, 3-4, UW, 10, 19-10, EEE, df, £801, 3a = AE ba en ges ie aise ue dique Cao Ai = car Conon a paris es cv a om pg Seat. En ses Jaen a = 2A & whaerain whan ha Sins 200 Saniancg Samaricas an aisremantinnes amin > ad, 30, WSS WHEN Ng amid 800 SEQUENTS CONDISSS an Ai0fSMENtioNed aming aye ene a din es an EN a ry CEN ANE NE oe nye pue dean oem Be Ÿ Heath eau Present aa bo Fly od ened août saauancs the amino acid saqduance arafarahlı further comprises a fa hut not

QG sequence, US AITHNG AGO SOQUONSS QUGTSTANIY runner COMPnses UD 10 (DUT MOLQG sequence, US AITHNG AGO SOQUONSS QUGTSTANIY runner COMPnses UD 10 (DUT MOL

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More Man) 110 SU, MOS DrSTOTADIY 110 LU, MOST DTOTSTEINY 110 TD aming acids, andiMore Man) 110 SU, MOS DrSTOTADIY 110 LU, MOST DTOTSTEINY 110 TD aming acids, andi

FY AN antinan nantige Samarlalan or onnsisting of an amin acid saauanea having loseFY AN antinan nantige Samarlalan or onnsisting of an amine acid saauanea having lose

LH SRE SIRE POLAT NHI Ian Ke CONSITUNG Mi dy ain ay lala SEC SEES WE ERS thon AON samiianeca Inantlhu ar ohm ilar fe fha native MME ALA antinan nannte gel aeLH SRE SIRE POLAT NHI Ian Ke CONSITUNG Mi dy ain ay lala SEC SEES WE ERS thon AON samiianeca Inantlhu ar ohm ilar fe fha native MME ALA antinan called gel ae

Han TUU7 SSQUENCS IGENRY OF SIMEAMY 10 INS Naive MUA-A SMUGEN DODUGE, SUCH asHan TUU7 SSQUENCS IGENRY OF SIMEAMY 10 INS Naive MUA-A SMUGEN DODUGE, SUCH as

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PAS HAVING ST GAS 070, MOIS rargiamy ol ddl VU 0, SOQUONCG IQOMAY (88 QanneQPAS HAVING ST GAS 070, MOIS rargiamy ol ddl VU 0, SOQUONCG IQOMAY (88 QanneQ

Ya ua aa À 5 Pan ANA ny ori \ = i & J Sw A bi pe gra” = te Lin FOTN SEN NOs:Ya ua aa À 5 Pan ANA ny ori \ = i & J Sw A bi pe gra” = te Lin FOTN SEN NOs:

Fara) fa an amine sein SONTIANSS aalartan fran Sa armen SANS SAN af Om IM NOFara) fa an amine sein SONTIANSS aalartan fran Sa pooren SANS SAN af Om IM NO

SPS) 0 an ating SCHE Sequence SSIQCIES Wom INS group CONSISUNG OF Sk HY NUE * *%* > & +2 AD AMD SA IE SE N DY A SIS ONS ss den an tes § pet = Rey pus yee À tes oo Sw a onan ad t ur ki tes AREA BE AY SRA AR 2 ARTNET GASEN TRS ANT SOITSPS) 0 an ating SCHE Sequence SSIQCIES Wom INS group CONSISUNG OF Sk HY NUE * *%* > & +2 AD AMD SA IE SE N DY A SIS ONS ss den an tes § pet = Rey pus yee À tes oo Sw a onan ad t ur kites AREA BE AY SRA AR 2 ARTNET GASEN TRS ANT SOIT

EL Sri, $ HD, EEE, ER, ASS, HA, QD, VISIO Wheh ine gaining GS aA RAS Anmnarilaas an nfaramantinnen coving acid cannancs The Smins aieEL Sri, $ HD, EEE, ER, ASS, HA, QD, VISIO Wheh ine gaining GS aA RAS Anmnarilaas an nfaramantinnen coving acid cannancs The Smins aie

SEQUENCE COMDMNSSS an afofeMentioned armifo acid SEQUENtS, INS ammo addSEQUENCE COMDMNSSS an afofeMentioned armifo acid SEQUENtS, INS ammo add

Pg 5 vp a onan ven Bn A AAA aed ae ren be Ft LÉ a Shaman) A den VAR A NSPg 5 vp a onan ven Bn A AAA aed ae ren be Ft LÉ a Shaman) A den VAR A NS

Sntanse nArafarahhe father samınrnscaa fin te Shi Hat mars Sham ~~ Ai MSTSntanse nArafarahhe father samınrnscaa fin te Shi Hat mars Sham ~~ Ai MST

Sequence proterally TUMMSF Comprises UD TD (DUT DOL More Mar 1 10 SU, More <a enim Fenn bn 9 den SN ARE wr en een bane oF Sen TE AAA RATS omen tieSequence proterally TUMMSF Comprises UD TD (DUT DOL More Mar 1 10 SU, More <a enim Fenn bn 9 den SN ARE wr en een bane oF Sen TE AAA RATS omen tie

ER afarahby 1 in ? mast nreferaniy Tia TS amino adidas angina ta PCSI GRNY FIV SU, TRS PIGISSGNIY TVQ LS IMMO SEE) LV OIHE afarahby 1 in ? mast nreferaniy Tia TS amino adidas angina ta PCSI GRNY FIV SU, TRS PIGISSGNIY TVQ LS IMMO SEE) LV OI

Sel sm ATLAS NANTES hin aim sures SN STAMOS SEIS ENS ar caneioting acaantiatbiv (0) EN antigen papliQa NEVIS an amine acid saguanie Comprising OT CONSISUNG assomianySel sm ATLAS NANTES hin aim sures SN STAMOS SEIS ENS ar caneioting acaantiatbiv (0) EN antigen papliQa NEVIS an amine acid saguanie Comprising OT CONSISUNG assomiany

FE mnt PES ARE ae ang ad od ole ab oven Tend x a Ÿ A bw IW ERS RNY A ew ena aE en TE Sn 3 Aen md af DANS ans amino acid substitution relative to the amino acid taguaneais) salacimetlFE mnt PES ARE ae ang ad od ole ab oven Tend x a Ÿ A bw IW ERS RNY A ew ena aE en TE Sn 3 Aen md af DANS ans amino acid substitution relative to the amino acid taguaneais) salacimetl

WA REY VOS AIS GS SUDSITUTION lOISTVS 10 ING amma adi SÉQUENLOIS) SHISCIESWA REY VOS AIS GS SUDSITUTION lOISTVS 10 ING amma adi SÉQUENLOIS) SHISCIES

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TOM INS group SONSISUNG oF mld IL NOS, 322 8, In, TO TB, 1.48, ZI, 28-81, aaTOM INS group SONSISUNG oF mld IL NOS, 322 8, In, TO TB, 1.48, ZI, 28-81, aa

TA TE RE en ca tn eu eu CR EN EN EN EN AN Sh ES GES EE Re NN EN eee EN THEN en ES CN enh Sn en Ean ae an a EN | en ; & wharain when he amis aon Sam Enea Sam cae an AINTOMEANTiNanNl ainTA TE RE en ca tn eu eu CR EN EN EN EN AN Sh ES GES EE Re NN EN eee EN THEN en ES CN enh Sn en Ean ae an a EN | en ; & wharain when he amis aon Sam Enea Sam cae an AINTOMEANTiNanNl ain

So WHSrEnN WHEN INS aMiNg 3610 SEQUENCE COMOPMSES an SOTSMESNTONSS amma “IM SAN ey EN EY PR Si SEN NEY ay ond ori = ea Se En PATES A = m + pt + +So WHSrEnN WHEN INS aMiNg 3610 SEQUENCE COMOPMSES an SOTSMESNTONSS amma “IM SAN ey EN EY PR Si SEN NEY ay ond ori = ea Se En PATES A = m + pt + +

RH SANtIDANPS Tha amide APT SANNIANSA NATATANS favthar SSSSANTIQA St NN TA hit nov <U BE SEQUENCS, INES aid adic SOQUENCE DFSTSTRDI TUITTET Comprises UD 10 (OUT MOL mare than 1 ia 30 more arafarabhb Tin DO moa! oratarabiy dis 18 armins acids: ancderRH SANtIDANPS Tha amide APT SANNIANSA NATATANS favthar SSSSANTIQA St NN TA hit nov <U BE SEQUENCS, INES aid adic SOQUENCE DFSTSTRDI TUITTET Comprises UD 10 (OUT MOL mare than 1 ia 30 more arafarabhb Tin DO moa! oratarabiy dis 18 armins acids: ancder

FROTQ Nan) 10 OU, MOTE ESTER. 110 £0, MOS Qreteraity PIS TO amino SS, andyFROTQ Nan) 10 OU, MOTE ESTER. 110 £0, MOS Qreteraity PIS TO amino SS, andy

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Fe a Imam mantis ia a SAVTTINEINET SRNSTTEST ar frntnantits Tha ARS aan Oo iano {G8 ONE DSDS, LE, 8 COMPBoUnd, CONSILEL, OF DONDSDIKS, INE aiming adi seguance onl yea been ie . GY WN Bh an oad Tac aay = SLR Ad al nes end pa N Tes Ed en ene Jed be Fal en x af which samoricag of aaa ang anfinen nantina as define in Hama (A) in (a) ahaaFe a Imam mantis ia a SAVTTINEINET SRNSTTEST ar frntnantits Tha ARS aan Oo iano {G8 ONE DSDS, LE, 8 COMPBoUnd, CONSILEL, OF DONDSDIKS, INE aiming adi seguance onl yea been ie . GY WN Bh an oad Tac aay = SLR Ad al nes end pa N Tes Ed en ene Jed be Fal en x af which samoricag of aaa ang anfinen nantina as defined in Hama (A) in (a) ahaa

LIE wna LUITRNSES SAD GS FIR SERIEN OS MRIS HE ASS (8) WL) SING, ed fone ane feyLIE wna LUITRNSES SAD GS FIR SERIEN OS MRIS HE ASS (8) WL) SING, ed fone ane fey

ANGIANGI

SE FRA any Semen ston ent en enone ee bo ae en ye NN EN ene ey eh i SN NN re en en Ea a ee ENTE ES NN SE eue ententes aeSE FRA any Semen ston ent en enone ee bo ae en ye NN EN ene ey eh i SN NN re en en Ea a ee ENTE ES NN SE eue ententes ae

DE fa) afandam pantide 19 a snmnnund cennefreni ar aniıneantina aamariclan ar canaiatingDE fa) afandam pantide 19 a snmnnund cennefreni ar aniıneantina aamariclan ar canaiating

A 18) a 1anGam paid, LE, à COMPOUNnG, CONSULER, OF DON DSDS COMPISING Of LORRYA 18) a 1anGam paid, LE, à COMPOUNnG, CONSULER, OF DON DSDS COMPISING Of LORRY

AE ond tev enasd Basen Gas ane oti ev re ae Sana oF at Bay nana Si À. À median at at lass ain iHantion AifTarant Nantifia SANtjipnnae at inact ann SI As NANAE ond tev enasd Bases Gas ane oti ev re ae Sana oF at Bay nana Si À. À median at at lass ain iHantion AifTarant Nantifia SANtjipnnae at inact ann SI As NAN

QF al Sas tw KOSTEN OF Giron DODUGS SegUenCes OF 8118881 ONS MLA-A antigen ots yoy Tan a SE ee SE A A Sie St AM © 33 an EC u See UN N ea ba ante and ane ST AA sn far WHE ALR antinan nantiste swafaralhiy Both na dafines inQF al Sas tw COSTS OF Giron DODUGS SegUenCes OF 8118881 ONS MLA-A antigen ots yoy Tan a SE ee SE A A Sie St AM © 33 an EC u See UN N ea ba ante and ane ST AA sn far WHE ALR antinan nantiste swafaralhiy Both well dafines in

DEDtdS ANG ONE HILAVA SRV MAD AUOT REN, ENGEN GUL go ASCHE iDEDtdS ANG ONE HILAVA SRV MAD AUOT REN, ENGEN GUL go ASH i

HI Fea) de EX 5 Ka ea ES AA ei aA An “i The Klee + SN EN eA dinerHI Fea) de EX 5 Ka ea ES AA ei aA An “i The Klee + SN EN eA diner

Tama fai tm fe SRY AIS TR St À STAY STATS ATOS ANTENNES NES TS ASP ArTama fai tm fe SRY AIS TR St À STAY STATS ATOS ANTENNES NES TS ASP Ar

Kems (8) 10 (0), IN WHON INS MLA STEIGEN DONT0SS arg ODTIONAINV HNKSO 10 each otngy by suitable linkers {So-calisd oligopantidest andorKems (8) 10 (0), IN WHON GET INTO MLA DONT0SS arg ODTIONAINV HNKSO 10 each otngy by suitable linkers {So-calisd oligopantidest andor

SY SUNAIIS INKED (SUSE ONQUDCPUOSS I, SO amy À fau ais Aa LA À À ANA ave enh rat eon eye me enema en ast dam Sia Se Sa Sen FE a ody san by AdesSY SUNAIIS INKED (SUSE ONQUDCPUOSS I, SO amy À fau ais Aa LA À À ANA ave enh rat eon eye me enema en ast dam Sia Se Sa Sen FE a ody san by Ades

AD fary orafarahly Hi AA antigen nentrles are as definad in HY a) and (a) rasnactivaly Alan 1812 WEY Ra ANY, TILAA AT DEDNGES arg ad GEHTIGG in (2, AN anid CS, FESDECOVOIV, ARQAD fary orafarahly Hi AA antigen nentrles are as defined in HY a) and (a) rasnactivaly Alan 1812 WEY Ra ANY, TILAA AT DEDNGES arg ad GEHTIGG in (2, AN anid CS, FESDECOVOIV, ARQ

Mn 8 doy ge SN ENE BR ETES an ene wats a & Sa I. ia A A on ent a « PSC nS ans pate RE CEE CUS En tien eut a in ha armhnnlirmmant assacrsiing fn fal fhe Hi ALA antinan nanticdas ara nrofaranh; Nafinaest neMn 8 doy ge SN ENE BR ETES an ene wats a & Sa I. ia A A on ent a « PSC nS ans pate RE CEE CUS Ent tien eut a in ha armhnnlirmant assacrsiing fn fal fhe Hi ALA antinan nanticdas ara nrofaranh; Nafinaest no

IM Ing gmopogimeam BETA 0 (SI, Wg MLA-A antigen SERIEN CS MSG QUE Y Wong ao described under fa) or (dd) In the case that the HLA-À antioen nentides as defined under (a)IM Ing gmopogimeam BETA 0 (SI, Wg MLA-A antigen SERIEN CS MSG QUE Y Wong ao described under fa) or (dd) In the case that the HLA-À antioen nentides as defined under (a)

SSL ANSE LE INS YSN AMF. EE EE A SE EE Fa SII NEN CS SOLS GDS ANSSSL ANSE LE INS YSN AMF. EE EE A SE EE Fa SII NEN CS SOLS GDS ANS

EAC Saad iEAC Saad i

FMOR GmbHFMOR GmbH

DRA ONNT DL Li BAND BAO Drees trv ie siesesbian DaftantearnenetbtonneDRA ONNT DL Li BAND BAO Drees trv ie siesesbian Daftantearnenetton

SAN ELL EAN LUXSIMOUTUISCHE Faenianimaiqung prior art.SAN ELL EAN LUXSIMOUTUISCHE Faenianimaiqung prior art.

That one of the aforementioned aming acid sequences, in particular as defined in items {a to {2}, may furiher comprises up to oui nol more than 1 to 30, more preferably 1 to 20, most increases the stably after administration to à subject, as they may be undergoing partial degradation from the C- and/or N-terminus after application, in à particular embodiment of the present invention, one of the aforementioned amine acid sequences, in particular as defined in teams (a to (C), comprises of preferably up to (but not comprise up to {but not more than 110 20, more preferably Tio 5 most preferably 110 TO amino a single amino acid sequence In accordance to the present invention, thus creasing a potsntiai 5/7 call response.That one of the mentioned acid sequences, in particular as defined in items {a to {2}, may further comprise up to nol more than 1 to 30, more preferably 1 to 20, most increases the stability after administration to à subject , as they may be undergoing partial degradation from the C- and/or N-terminus after application, in à particular embodiment of the present invention, one of the mentioned amine acid sequences, in particular as defined in teams (a to (C) , comprises of preferably up to (but not comprise up to {but not more than 110 20, more preferably Tio 5 most preferably 110 TO amino a single amino acid sequence In accordance with the present invention, thus creating a potsntiai 5/7 call response .

The use of compounds, constructs or polypeptides as defined under (6) according to the peptides, has the further advantage that the longer amine acid sequences of the compounds, constructs, profains or polypeptides result in à longer retention time in the tissue of the subject application to the subject can, for example by endogenous enzymes into smaller fragments biologicaliy desired function in the sense of the invention, That is, the individual fragments of the gligopeptide axhibil activity as HLA-A and/or HLA-B antigen peptides and thus contribute tothe activation of T cells,The use of compounds, constructs or polypeptides as defined under (6) according to the peptides, has the further advantage that the longer amine acid sequences of the compounds, constructs, profains or polypeptides result in à longer retention time in the tissue of the subject application to the subject can, for example by endogenous enzymes into smaller fragments biologically desired function in the sense of the invention, That is, the individual fragments of the gligopeptide axhibil activity as HLA-A and/or HLA-B antigen peptides and thus contribute to the activation of T cells,

HLA-B antigen peptide of the invention” (also called "HLA-B antigen peptide”) or "amine acid sequence of the invention” (as defined herein}, which comprises the following:HLA-B antigen peptide of the invention” (also called “HLA-B antigen peptide”) or “amine acid sequence of the invention” (as defined herein}, which comprises the following:

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TS of \ nnlavas which ie similar more orefarably identical esponding to MHC class | complexes which is similar or more PSS AR Y GGINILETS of \nnlavas which ie similar more orefarably identical esponding to MHC class | complexes which is similar or more PSS AR Y GGINILE

COrTespont Gi MIT GIASS | LLANES WENN 3d 3COrTespont Gi WITH GIASS | LLANES IF 3d 3

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VTUS nprésentec sou Ka Sr LES VS RATE KE AAN A X A NVTUS nprésentec sou Ka Sr LES VS RATE KE AAN A X A N

VITUS IRIEL LY UIE sure > iVITUS IRIEL LY UIE sure > i

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ARE + =; 2 A Lit A A tam 8 3 + ea ii; À antisan lan at dafinad ahave far the BME AA anti sn ling to the Invention ai a concentration, as defined above for the HLA-A ANTARE + =; 2 A Lit A A tam 8 3 + ea ii; À antisan lan at dafinad ahave far the BME AA anti sn ling to the Invention ai a concentration, as defined above for the HLA-A ANT

SCCOTOITO 10 INS HIVONTION ST 8 CONCENTTATION, 88 qannaqSCCOTOITO 10 INS HIVONTION ST 8 CONCENTTATION, 88 qannaq

SCCOrong LL AI MIVONILIQI Où 0 À XSCCOrong LL AI MIVONILIQI Où 0 À X

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TT dratinin af nrafteraihhe af laaet i $3 in absolute concantration of nrafarabiy at least 1 Hid of at feast 100 LG alternatively ET Anse CONceOntTation ww pet Tsay X va il DES, OT a TIC & ) CS ANNE NN N AAS DNR peptide, OT Gi CAN il ug, ail à ¥ a . Ta m m ; A cuisse A Ray aasdian € harmaceuticai composition to be applisg, at i oalume of the pharmaceutk À GAATEIRALISINLN VS OSTT dratinin af nrafteraihhe af laaet i $3 in absolute concentration of nrafarabiy at least 1 Hid of at feast 100 LG alternatively ET Anse CONceOntTation ww pet Tsay X va il DES, OT a TIC & ) CS ANNE NN N AAS DNR peptide, OT Gi CAN il ug, ail à ¥ a . Ta m m ; A cuisse A Ray aasdian € harmaceuticai composition to be applied, at i oalume of the pharmaceutk À GAATEIRALISINLN VS OS

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Ny & Ges Kr Be last EA sa cond an as defined shaue in noînt (hi ‘ eS Qs . irda ara salacrtas ac Afatina à CHLMLAVXS III RAIL LA). © jai 3 A antigen pantigdes are seiedclan as dahned above N AH ;Ny & Ges Kr Be last EA sa cond an as defined shaue in noînt (hi ‘ eS Qs . irda ara salacrtas ac Afatina à CHLMLAVXS III RAIL LA). © jai 3 A antigen pantigdes are seiedclan as dahned above N AH ;

Preferabiy, the HLA 3 ANGEn DODUO SAT OCR NS ORNE RORTS LA RD OMAN ; \Preferabiy, the HLA 3 ANEn DODUO SAT OCR NS ORNE RORTS LA RD OMAN ; \

FESTEN, WE MLA SC MRIS QE x Ÿ ~ Y im + REALE antinan nantige” prafarabhy far ferred embodiment, an “HLA-S antigen nentide” preferablFESTIEN, WE MLA SC MRIS QE x Ÿ ~ Y im + REALE antinan nantige” prafarabhy far ferred embodiment, an “HLA-S antigen nentide” preferabl

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ONT ING Grou CONSISENG OF DEUX 2 NUS £4, 5, : 5 TS = oS X El : : 5 x ~ x €, EE ASAT aan sie : Ie ae NY 4 Seamnaricas an afaramantianan aming acio haralnı when the amino acid ssqgusnee COMPBNSEs AN aioigmantionsg amine agiONT ING Grou CONSISENG OF DEUX 2 NUS £4, 5, : 5 TS = oS aioigmantionsg amine agi

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SAS SEQUENcEe, LÉ DIS AA VU MISSILES à 3SAS SEQUENcEe, LÉ DIS AA VU MISSILES à 3

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Sal ï tn tha native Mi AIS antinen nantide such as &} y 1005646 sequence identity or similarity ia the native HLAR antigen BED, SUCH at han FANS SCHUHE SDT VE Drain y = x Loa ; afin st ; RAS Sana Ifantih: fae dafinast = a a fanned KO Séquence identity (‘as dcetned © Pa Ne re FN eM a DAT Sais da SET! NCE GTV EER 18TH : Dan cad innot DIRQ mors preferably at least 509, ssouence viSal ï tn tha native Mi AIS antinen nantide such as &} y 1005646 sequence identity or similarity ia the native HLAR antigen BED, SUCH at han FANS SHOES SDT VE Drain y = x Loa ; afin st ; RAS Sana Ifantih: fae dafinast = a a fanned KO Séquence identity (‘as dcetned © Pa Ne re FN eM a DAT Sais da SET! NCE GTV EER 18TH : Dan cad innot DIRQ mors preferably at least 509, ssouence vi

ESSEN AY IRAN ANA mars AETEiainy al IQast où ; iESSEN AY IRAN ANA mars AETEiainy al IQast où ; i

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SENET EET a an AIOTEMENTIOHSS ammo 3840 Squen ,SENET EET a an AIOTEMENTIOHSS ammo 3840 Squen ,

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DISTSTSDIV TUITHIST Comprises up io (DUT NOLM ;DISTSTSDIV TUITHIST Comprises up io (DUT NOLM ;

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Fey $i nopntiols having an aming acid Seduerice CONIDIISITO LLIN 255ehua SyFey $i nopntiols having an amic acid Seduerice CONIDIISITO LLIN 255ehua Sy

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PMCR S bi a : Aare ie en Datanterimmues tin eo 28.02 2023 Luxemburgiscne PalantanmeldungPMCR S bi a: Aare ie en Datanterimmues tin eo 28.02 2023 Luxembourgish patent application

PRC-O007-PLU FARPRC-O007-PLU FAR

PMO-OG07-P-LU an >PMO-OG07-P-LU to >

LU103079 wherein when the amino acid sequence comprises an aforementioned amino acid sequences, the amine acid sequence preferably further comprises up fo {put not mors comprises at least one antigen peptide as defined in tema {a} through (0) above; and/or {2} a tandem peptide, Le, à compound, construct, or polypeptide comprising or consisting peptide and one HLA-A and/or HLA-B, preferably both as defined in lems {a} to (0) In which the HLA antigen peptides are optionally connected to each other by suitable inkare fer malen alinanantigdea) iQ HEROES (SU-LANSU CHYOPOPULESS}.LU103079 wherein when the amino acid sequence comprises an aforementioned amino acid sequences, the amine acid sequence preferably further comprises up fo {put not mors comprises at least one antigen peptide as defined in tema {a} through (0) above; and/or {2} a tandem peptide, Le, à compound, construct, or polypeptide comprising or consisting peptide and one HLA-A and/or HLA-B, preferably both as defined in lems {a} to (0) In which the HLA antigen peptides are optionally connected to each other by suitable inkare fer malen alinanantigdea) iQ HEROES (SU-LANSU CHYOPOPULESS}.

Also in the embadiment according to {8), the HLA-B antigen peptides are preferably defined under fem (se) are linked to each other vig à linker, suitable linkers are known to the person skilled in {he art from the prior artAlso in the embadiment according to {8), the HLA-B antigen peptides are preferably defined under fem (se) are linked to each other vig à linker, suitable linkers are known to the person skilled in {he art from the prior art

That one of the afbrementionsd amino acid sequences, in particular as defined in tems (a) fo {a}, may further comprise up fo (but not more than) 1 to 30, more preferably 1 to 20, most preferabiy 1 to 15 amino acids in addition to the HLA-9 antigen peptide, has the advantage degradation from the C- and/or N-terminus after application. since they are more economic in the preparation and synthesis than longer peptides. acids in length are especially preferred as antigen polypeptides in the spirit of the current invention since they are more eoonomic in the preparation and synthesis than longer peptides, ; PEPIN eambodiment of the prasent invention, one of the aforementioned amino acidThat one of the afbrementionsd amino acid sequences, in particular as defined in tems (a) fo {a}, may further comprise up fo (but not more than) 1 to 30, more preferably 1 to 20, most preferably 1 to 15 amino acids in addition to the HLA-9 antigen peptide, has the advantage degradation from the C- and/or N-terminus after application. since they are more economical in the preparation and synthesis than longer peptides. acids in length are especially preferred as antigen polypeptides in the spirit of the current invention since they are more eoonomic in the preparation and synthesis than longer peptides, ; PEPIN eambodiment of the present invention, one of the aforementioned amino acid

In & particular ambodimeant of the prasent Invention, ong of the atorgmantion in particular as defined in ams ‘at to (©! comprises of preferably up to (but notIn & particular ambodimeant of the present invention, ong of the atorgmantion in particular as defined in ams ‘at to (©! comprising of preferably up to (but not

SÉQUENCES, MN DANICUIET 35 Gained IM OMS (3) 10 (0), COMPHSSS OT DIOIGTANIV Ww { comprise up to {but not more than 1 to 20, more preferably 110 15 most preferably 1 io 10SÉQUENCES, MN DANICUIET 35 Gained IM OMS (3) 10 (0), COMPHSSS OT DIOIGTANIV Ww { consist up to {but not more than 1 to 20, more preferably 110 15 most preferably 1 io 10

Paie Sep ; 28.02 2023 Luxemburgische PalentanmeldungPaie Sep ; 28.02 2023 Luxembourg Palent Declaration

PMC-0007-P-LU 28.02 2023 Luxemburg qPMC-0007-P-LU 28.02 2023 Luxembourg q

PF SESPF SES

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In an aspect of the currant invention which discloses a particularly preferred embodiment, the # HLA-À and/or HLA-R antigen nentides of the nrasant invention are selected in such a way that > TILA-A NM PLA ANTIQON DEINES OT ING radon Mysnuion arg SOIGGISG HT SUCH à Way, inal they match or correspond to COONEVRIUS, preferably belacoronaviruses, more preferably domain, nucleocapsid protein, envelopes protein and/or ORF Tab polvorofein, which are highly variants. This has the technical effect, that the combination preparation relating to the aforementioned antigen peptides is less susceptible against RNA mutations in new strains and (broadband) immunization. Correct sequence matching can be achigved by comparing the preferably with respect to the spike 81 domain, 92 domain, nucleocapsid protein, envelopes protein and/or ORF Tab polyprotein, that are (D) identical to each other or {i having an amino acid sequence comprising or consisting easentially of only one amino acid substitution relative sequences. if has been found fo be particularly advantageous to compare not only different (betacoronaviruses), Dui at least different mulants within à subgenus (Sarbecovirust, This invention to be used not only for the treatment of a specific virus types (such as SARS-CoV 1, at least subfamiby-spanning, particularly preferably genus-spanning, especially subgenus. coronaviruses within the coronavirus family, preferably with a (multiple) sequence alignmentIn an aspect of the current invention which discloses a particularly preferred embodiment, the # HLA-À and/or HLA-R antigen nentides of the nrasant invention are selected in such a way that > TILA-A NM PLA ANTIQON DEINES OT ING radon Mysnuion arg SOIGGISG HT SUCH à Way, inal they match or correspond to COONEVRIUS, preferably belacoronaviruses, more preferably domain, nucleocapsid protein, envelopes protein and/or ORF Tab polvorofein, which are highly variants. This has the technical effect, that the combination preparation relating to the aforementioned antigen peptides is less susceptible against RNA mutations in new strains and (broadband) immunization. Correct sequence matching can be achieved by comparing the preferably with respect to the spike 81 domain, 92 domain, nucleocapsid protein, envelopes protein and/or ORF Tab polyprotein, that are (D) identical to each other or {i having an amino acid sequence comprising or consisting easily of only one amino acid substitution relative sequences. if has been found fo be particularly advantageous to compare not only different (betacoronaviruses), Dui at least different mulants within à subgenus (Sarbecovirust, This invention to be used not only for the treatment of a specific virus types (such as SARS-CoV 1 , at least subfamily-spanning, particularly preferably genus-spanning, especially subgenus coronaviruses within the coronavirus family, preferably with a (multiple) sequence alignment

FMCR GmbHFMCR GmbH

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LU103079 coronavirus QU4S, UNIPROT reference: P3488, Human coronavirus HKUT {isolate NB),LU103079 coronavirus QU4S, UNIPROT reference: P3488, Human coronavirus HKUT {isolate NB),

GHMQCE; and savers acute respiratory syndrome coronavirus 2, UNIPROT reference:GHMQCE; and savers acute respiratory syndrome coronavirus 2, UNIPROT reference:

In an alternative embodiment of the invention, the SARS-CoV-2 apike protein was aligned against 5 different coronaviruses within the coronavirus family (Human coronavirus 2288,In an alternative embodiment of the invention, the SARS-CoV-2 apike protein was aligned against 5 different coronaviruses within the coronavirus family (Human coronavirus 2288,

Human coronavirus HKUT Gsolate NS) UNIPROT reference: QOIMET, Human coronavirus corresponding to MHC class | complexes in accordance with the present invention. acid sequence of the invention) used in the invention binds to à T call receptor of endogenous nantide sanusnce BF ahnuid he noted that "san chnaciiicatie bing to” and ''ensoiticaie hinds te”Human coronavirus HKUT Gsolate NS) UNIPROT reference: QOIMET, Human coronavirus corresponding to MHC class | complexes in accordance with the present invention. acid sequence of the invention) used in the invention binds to à T call receptor of endogenous nantide sanusnce BF ahnuid he noted that “san chnaciiicatie bing to” and ''ensoiticaie hinds te”

PUAIINMS STE LELE CSI, SL SIH OID TITEL WIGHT Le] SRIRAM AL QUE IY SLT GT YAS WWPUAIINMS STE LELE CSI, SL SIH OID TITLE WIGHT Le] SRIRAM AL QUE IY SLT GT YAS WW

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LS MAIO ES AGFA ERS END QIN QG DGSE DS BELLI A WISIN ASS Bolle NT ane invention into a single polypeptide of the invention. In particular, has been demonstrated that invention have unique hindina nronarties of Fig. 3 [AN WISI TIENT MEIN PRIN I OBAMA RING (Ted Pag. 470LS MAIO ES AGFA ERS END QIN QG DGSE DS BELLI A WISIN ASS Bolle NT an invention into a single polypeptide of the invention. In particular, has been demonstrated that invention have unique hindina nronarties of Fig. 3 [AN WISI TIENT MEIN PRIN I OBAMA RING (Ted Pag. 470

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PMC-0C07-P-LU 28.02 2023 Luxemburgische Palentanmeldung enPMC-0C07-P-LU 28.02 2023 Luxembourg Pallet Registration en

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AN SIN SANS DES fEBCONHSHILITADS ary MET GUAT, UV S, § > > &MLNSIONS, SUSPENSIONS, TRA) TULUTIONEGLGINIE y ob 3 } i € PO pa Iinlastinne nr sah tian fad ¥. ï (HSiANES are Nastinne ar aalidinne = 3 Schr rata era et sheen Favre ior 376 injections OT SOI ionsAN SIN SANS DES feBCONHSHILITADS ary MET GUAT, UV S, § > > &MLNSIONS, SUSPENSIONS, TRA) TULUTIONEGLGINIE y ob 3 } i € PO pa Iinlastinne nr saw tian fad ¥. ï (HSiANES are Nastinne aalidinne = 3 Schr rata era et sheen Favre ior 376 injections OT SOI ions

Particularly prefered drug TONTRHATONS as INeQiong OT SDILTIONS.Particularly preferred drug TONTRHATONS as INeQiong OT SDILTIONS.

FRIUCUHATY prasad VIOL naan | 3 : e, ais me + 3 XS Wakila annliratar Soins arafaraihiy a8 a “« 2 I Farin ie nrasant in à quais anni ation device, preferably as aFRIUCUHATY prasad VIOL naan | 3 : e, ais me + 3

Atarmatively tha dron formulation is Grasait NT à SUNSDIS Sppicaion DEV 5 NN X >Atarmatively the dron formulation is Grasait NT à SUNSDIS Sppicaion DEV 5 NN X >

Aternatveiy, INS VU ITED D Tea | 1 ie oi i $ sconstitution with a charmaceuticaily accentable x Cor x . © enn fv aN AN aN hich allows in su reconstitution with = pharmaceutically acceptableAternatveiy, INS VU ITED D Tea | 1 ie oi i $ sconstitution with a charmaceuticaily accentable x Cor x . © enn fv aN AN an hich allows in su reconstitution with = pharmaceutically acceptable

EN ren hi isn mo sure uch le © HOWS HT SHU l'ECONSTAUTION with a8 gnam y § aA ÖVODTENZEIS IN 8 STEINE, WIDTH SUAS HT DRL FEL à fa sdi ; adie aobidion fan salinaEN ren hi isn mo sure also le © HOWS HT SHU l'ECONSTAUTION with a8 gnam y § aA ÖVODTENZEIS IN 8 STEIN, WIDTH SUAS HT DRL FEL à fa sdi ; Goodbye aobidion fan salina

SOLON L.A SAIS ï N + 4 EEA median mania : os Are toy of Lens! ane MEA aatinan entire i tt nfioen polvpantide corresponding to at ICQ NIRS FILA SUIT Rae in one embodiment, the antigen polvpeptids cor Sah ALAIN AL QL Iai AIT LA CRI + ESSOLON L.A SAIS ï N + 4 EEA median mania : os Are toy of Lens! ane MEA aatinan entire i tt nfioen polvpantide corresponding to at ICQ NIRS FILA SUIT Rae in one embodiment, the antigen polvpeptides cor Sah ALAIN AL QL Iai AIT LA CRI + ES

HI ONS SMDOdITISTT IS QINIGET PLUS LUGE CUS SONNIG © ine ief, intact rin $A RK Fares daten i ; rs mA is farmulatec ar ie te he farmuiiates © qu ga” 1 X i. Arte arming nelle is farmitiatec aria ta he formulated 5 Uno to MHC class complexas orthe amino acids is formulated oristo he formulaHI ONS SMDOdITISTT IS QINIGET PLUS LUGE CUS SUNNY © ine ief, intact rin $A RK Fares data i ; rs mA is farmulatec ar ie te he farmuiiates © qu ga” 1 X i. Arte arming nelle is farmitiatec aria ta he formulated 5 Uno to MHC class complexas orthe amino acids is formulated oristo he formula

COYITESPONTHNQ 10 AML GIASS | CONDIEXES Oring aming ACIOS IS HERCOYITESPONTHNQ 10 AML GIASS | CONDIEXES Oring aming ACIOS IS HER

CO responding LS IIT. ice à COMREXE > A XCO responding LS IIT. ice à COMREXE > A X

Sad BA ; Minadises FharoantSad BA ; Minadises Fharoant

Haniel a san Ar a snamhinationn fharantHaniel a san Ar a snamhinationn fharant

AR 9 MO a NE 20 ES SAT ENT Ÿ sreoi. asa HUQ, a Sons, ÂGE CA Lin ania) angry es 3 [A ead «be ddan $3 i Mian Farm dation asearding ta tha ça + _ Grue Bn a Fiend Arn nae isan Seen sation acenrading to the © f bi } {medicament oharmasceutical comnostiorrtTormulation ALLUDING WY ASAR 9 MO a NE 20 ES SAT ENT Ÿ sreoi. asa HUQ, a Sons, ÂGE CA Lin ania) angry es 3 [A ead «be ddan $3 i Mian Farm dation asearding ta tha ça + _ Grue Bn a Fiend Arn nae isan Seen sation acenrading to the © f bi } {medicament oharmasceutical comnostiorrtTormulation ALLUDING WY AS

Da Drofarahh: tha fmanipamant SINCAT TENNIS AL Le TE ANT TRADER PIE D TT DS IRTECRANET 3Da Drofarahh: tha fmanipamant SINCAT TENNIS AL Le TE ANT TRADER PIE D TT DS IRTECRANET 3

EI Froeteraniy, The (ICAISTEIG NS hanna Sati 4 } $ inérathoans! anthsirat sp He) quais ca Than ét tte ENS infrathanat Aare re i i {i N QUE UT RITIUISOLUAI SUDOUTSITISGOQUES ILE CAL GE Ian CAT x €: © rid en bai I WT TRIN NAY SUDOUTSTHISOUS er siecat, se ,EI Froeteraniy, The (ICAISTEIG NS hanna Sati 4 } $ inérathoans! anthsirat sp He) quais ca Than ét tte ENS infrathanat Aare re i i {i N QUE UT RITIUISOLUAI SUDOUTSITISGOQUES ILE CAL GE Ian CAT x €: © rid en bai I WT TRIN NAY SUDOUTSTHISOUS he siecat, se ,

HIVSntioNn IS SUNSDIE for Intrav SS SERIES DIS TERE, Sua = ; , SHIVSntioNn IS SUNSDIE for Intrav SS SERIES DIS TERE, Sua = ; , p

VENTION IS SURAaNe Tor mraveng MS, HA ,VENTION IS SURAaNe Tor mraveng MS, HA ,

I ; =. + + EN ENN NES oN + 4 Hi = LA der Seien fre subcutanaaus oF $ i i a. hE ene sith Sache armas) fermi ons for suboulaneaus OFI ; =. + + EN ENN NES oN + 4 Hi = LA der Be fre subcutanaaus oF $ i i a. hE ene sith thing armas) fermi ons for suboulaneaus OF

X ps : ARE administration with Mariana ARATE ILRI EY TAY una) X transdermal or nasal Sdninistration, with PHL aI usdX ps : ARE administration with Mariana ARATE ILRI EY TAY una) X transdermal or nasal Sdninistration, with PHL aI usd

Tanhsdermai OF Nasal agniinisiranon, WAT X ; a 4 § €, soi Ges lee nrefarres amhnadimand ; Le ce : : ea ee nrofarros In a nerfisiitauhe oreferred embodiment int ministration Dana particularly prefers: PQ RACH AIL LAI TY RAEI GMA Shaan nie dt Earana ie aomirniotraty OMNES FET ANA AARON CHEN OAL HEY CD Raat anal ty NTanhsdermai OF Nasal agniinisiranon, WAT X ; a 4 § €, soi Ges lee nrefarres amhnadimand ; Le ce : : ea ee nrofarros In a nerfisiitauhe oreferred embodiment int ministration Dana particularly prefers: PQ RACH AIL LAI TY RAEI GMA Shaan nie dt Earana ie aomirniotraty OMNES FET ANA AARON CHEN OAL HEY CD Raat anal ty N

MMEEVSNOUS admiisiranon NIGH MO UGMRRIIY Wise } AMMEEVSNOUS admiisiranon NIGH MO UGMRRIIY Wise } A

N & ae Enenes din 3 ï 345 ; Ayayılie tan aide aman ie Thia hao tha ‘ . . ‘ acrantical camnacitian is anntisntac subeutaneonus Thig has the étage EN L Sen EE gm hen Sdn on Aaharmacandiceal or AMOS à anpiicated subcutaneous. YiN & ae Enenes din 3 ï 345 ; Ayayılie tan aide aman ie Thia hao tha ‘ . . ‘ acrantical camnacitian is anntisntac subeutaneonus Thig has the étage EN L Sen EE gm hen Sdn on Aaharmacandiceal or AMOS à anpiicated subcutaneous. Yi

OF the invention, ing ASTA TEA NEO LUIGI IS SHAR ; Ce . re Cs ied 9 feat HA à Nanné Three affant ann $ 3 { \ À Santina degradation and a deonat forrmiri al antOF the invention, ing ASTA TEA NEO LUIGI IS SHAR ; Ce. re Cs ied 9 feat HA à Nanné Three affant ann $ 3 { \ À Santina degradation and a deonat forrmiri al ant

N } i oad age of reduced antigen pantide degradation EHH ERC ERE LS CARI LEE RHR TO va FEN FR 18 ischnical advantage of reduced antigen paphide degradation and a À U 2 (SCHOEN agvaniage LH TELLIER GIE OiS Jaw \ “a se $3 soivnentide is slowly delivered to the subiectN } i oad age of reduced antigen pantide degradation EHH ERC ERE LS CARI LEE RHR TO va FEN FR 18 ischnical advantage of reduced antigen paphide degradation and a À U 2 (SCHOEN agvaniage LH TELLIER GIE OiS Jaw \ “a se $3 soivnentide is slowly delivered to the subject

Starr AS ASSET FANDEN I IE HV Rives) ID TS Suga.Starr AS ASSET FANDEN I IE HV Rives) ID TS Suga.

WS, Wg APE PUY POPNUS 10 SLIM envi 3WS, Wg APE PUY POPNUS 10 SLIM envi 3

PACER SimbH | N ere bares irvine rei ren Datantantmeatntines iO LU 28.02 2023 LUXEMOUTEISCHS FaenianimaiqungPACER SimbH | N ere bares irvine rei ren Datantantmeatntines iO LU 28.02 2023 LUXEMOUTEISCHS Faenianimaiqung

PRC-O007-PLU LOL ENTE {3PRC-O007-PLU LOL DUCK {3

FOND SEULS the antigen polypeptides are formulated or are to be formulated for injection.FOND SEULS the antigen polypeptides are formulated or are to be formulated for injection.

In one embodiment, the HLA antigen peptide corresponding to MHC class | complexes and/or the antigen polypeptides are formulated or ars lo be formuiaied for intramusoular ong embodiment, the pharmaceutical compoaitionfformulation is a vaccine. is to be formulated as particles. gach antigen polypeptide, IF 1 is part of the pharmaceutical composition, for the therapeutic or may be administered at an absolute concentration per dose of the pharmaceutical composition up to 400 ug, up to 450 ug, up to SOU ug Or up to 550 ug may be administered. In one embodiment, the invention relates to à single dose administration, In one embodiment, the invention relates to the administration of à priming dose followed by ong or more booster dAncas The hanstar dose or tha first hnnpater docs may he anministaran Fin 28 dave ar 14 inIn one embodiment, the HLA antigen peptide corresponding to MHC class | complexes and/or the antigen polypeptides are formulated or can be formulated for intramusoular ong embodiment, the pharmaceutical composition is a vaccine. is to be formulated as particles. gach antigen polypeptide, IF 1 is part of the pharmaceutical composition, for the therapeutic or may be administered at an absolute concentration per dose of the pharmaceutical composition up to 400 ug, up to 450 ug, up to SOU ug Or up to 550 ug may be administered. In one embodiment, the invention relates to à single dose administration in

QOUES. IS DOOSIET QOLSE OF IMS HITS DOORS, GOSSES ay Se Saminisiargd / 10 Lo Gays OF TS 16 24 davs following administration of the priming doseQOUES. IS DOOSIET QOLSE OF IMS HITS DOORS, GOSSES ay Se Saminisiargd / 10 Lo Gays OF TS 16 24 davs following administration of the priming dose

EN LS Uae VOTE AU HS TGS OF ine Priming GOSE. gach antigen peptide, i it is part of the pharmaceutical composition, for the therapeutic or may be administered at an absolute concentration per dose of the pharmaceutical composition this greatly intensifies the therapeutic effect. This is particularly advantageous I the immune system of the subject to be treated is already weakened by other pre-dissase, eg, renal disease, chronic pulmonary disease, ADSM, any malignancy, lymphoma or metastatic solid tumor and possibly associated pretreatment tharsol, or if the subject alreadyEN LS Uae VOTE AU HS TGS OF ine Priming GOSE. This antigen peptide is part of the pharmaceutical composition, for the therapeutic or may be administered at an absolute concentration per dose of the pharmaceutical composition, this greatly intensifies the therapeutic effect. This is particularly advantageous I the immune system of the subject to be treated is already weakened by other pre-dissase, eg, renal disease, chronic pulmonary disease, ADSM, any malignancy, lymphoma or metastatic solid tumor and possibly associated pretreatment tharsol, or if the subject already

PMCR GmbHPMCR GmbH

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SL, antigen peptide containing amine acid sequences corresponding io at least two viral infecligus diseases, if # is pad of the pharmaceutical composition, for the therapeutic or prophylactic treatment of à viral Infectious disease, especially for the therapeutic treatment, may be preforably at an absolute concentration of al least 800 ug, Le, containing at least inthe range intensifies the therapeutic affect and allows for simuilansous immunization against at isast fwo pharmaceutical composition allowing for immunization against at least two different vival infectious diseases,SL, antigen peptide containing amine acid sequences corresponding io at least two viral infecligus diseases, if # is pad of the pharmaceutical composition, for the therapeutic or prophylactic treatment of a viral infectious disease, especially for the therapeutic treatment, may be preferably at an absolute concentration of at least 800 ug, Le, containing at least inthe range intensifies the therapeutic affect and allows for simuilansous immunization against at isast fwo pharmaceutical composition allowing for immunization against at least two different vival infectious diseases,

In ong embodiment, administration of the pharmaceutical composition as described herein,In ong embodiment, administration of the pharmaceutical composition as described,

Anta aNMunisiration mast nartimaderiu afar hire dace adminmiciratinn at tha sharmaca dies!Anta aNMunisiration mast nartimaderiu afar hire dace adminmiciratinn at tha sharmaca dies!

GOSE AQMINHSITRNCN, MOST PartilUTaiy anay IN GOSS aqivhinisialion OP INS pnarMmacaiiica composition with an administration dose as described harsin results in an IFNy activity in theGOSE AQMINHSITRNCN, MOST PartilUTaiy anay IN GOSS aqivhinisialion OP INS pnarMmacaiiica composition with an administration dose as described harsin results in an IFNy activity in the

AMTES TEICHE ANETTE QUITHIST ENON QOSS AD GOSCIDOU NETT TODURS in an i NY GUVRY HANS blood serum of the subject in a range of at least 50 to 500, More preferabiy a range of at least more preferably administration of the pharmaceutical composition with an administration dose composition with an administration dose as described herein results in an IFNy cell count per 100 O00 cells in the hiood serum of the subieci in a ranne of at least 28 to S00 cells. moreAMTES TEICHE ANETTE QUITHIST ENON QOSS AD GOSCIDOU NETT TODURS in an i NY GUVRY HANS blood serum of the subject in a range of at least 50 to 500, More preferabiy a range of at least more preferably administration of the pharmaceutical composition with an administration dose composition with an administration dose as described results in an IFNy cell count per 100 O00 cells in the high serum of the subieci in a range of at least 28 to S00 cells. more

VER APPLE LEIS CDS LOIS RAMRSREAS D0 dl ASS LIRE SEN ny OQ VRE WL IS Qa 1 GU tale, MEARSVER APPLE LEIS CDS LOIS RAMRSREAS D0 dl ASS LIRE SEN ny OQ VRE WL IS Qa 1 GU tale, MEARS

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Sal 4 : 3s gL a - > AE SES + oy on pad din es nina eus ON ot em Te pa es ae pu PY CAES asus Kiel 1x a let Tye is nana 8 3 3 va x Fear atin 1e ae le Thus : ane ee C : FEN Prd ian NEVE PYF HionSformuiation 8 a gt PRIUS, N ons i = > } MS! the pharmaceutical com FOSHNATTOIT IHU IS AONE 3 in one mbogimsy [HEE SEI DEGRA a) AA IR STU A ra iN ang smbooiment, LS MIR Ie 3Sal 4 : 3s gL a - > AE SES + oy on pad din es nina eus ON ot em Te pa es ae pu PY CAES asus Kiel 1x a let Tye is nana 8 3 3 va x Fear atin 1e ae le Thus : ane ee C : FEN Prd ian NEVE PYF HionSformuiation 8 a gt PRIUS, N ons i = > } MS! the pharmaceutical com FOSHNATTOIT IHU IS AONE 3 in one mbogimsy [HEE SEI DEGRA a) AA IR STU A ra iN ang smbooiment, LS MIR Ie 3

X A + + nn » + a a { { J Seve Rn iors ï 4 RAL lass | commiexas ar tha antinat 3 43 Ada Hparrecnnnninn tn RALF diass | complexes or tha antiasn : 2: a Fa antinan mantis sarraonanoiing HA MN & MNX A + + nn » + a a { { J Seve Rn iors ï 4 RAL lass | commiexas ar tha antinate 3 43 Ada Hparrecnnnninn tn RALF diass | complexes or tha antiasn : 2: a Fa antinan mantis sarraonanoiing HA MN & MN

SITQOOGHTIENT INE SINTOSN. OS 0108 AERO WIT 3 LXE o oSITQOOGHTIENT INE SINTOSN. OS 0108 AERO WIT 3 LXE o o

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DOIVDEDTICS CAIN LAs iany ATS Redit ater ig 3 ; ;DOIVDEDTICS CAIN LAs iany ATS Redit ater ig 3 ; ;

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CHUONT ani ARRAS SW HE GE } = Net a on N Sean » saut 4 A ~ ~ ~ on Comend ave ID ~ 3 on ea my or Et stitic al camnasitions Oar cnencte x $ TN à Far tha 5 nATation of sharmacautiosl compassion 18 losange ï Rat! ie roman in the DOP art toi à he Dr'enaTatioN OÙ Pharmaceutical COMPOSTIONS ak CITCHUONT ani ARRAS SW HE GE } = Net a on N Sean » saut 4 A ~ ~ ~ on Comend ave ID ~ 3 on ea my or Et stitic al camnasitions Oar cnencte x $ TN à Far tha 5 nATation of sharmacautiosl compassion 18 losange ï Advice! The novel in the DOP art toi à he Dr'enaTatioN OÙ Pharmaceutical COMPOSTIONS ak CIT

SUTOGS KNOW © SELIG RAT ORS nd ® 3 + VMOUIOGS KITQOWT GN INS MIRE CHEN à X } ; } = so + A # 7 + W I hai st ans sin ; fool QaansnneT DharmanowisatSUTOGS KNOW © SELIG RAT ORS nd ® 3 + VMOUIOGS KITQOWT GN INS MIRE CHEN à X } ; } = so + A # 7 + W I hai st ans sin ; fool QaansnneT Dharmanowisat

TS ; § S 3 le "Naminaton's Pharmaceutical SCIENCES FRS IOGO QT Lai f re found ir QF EXampbie NEMNQION'S PFIAIMACSUTCAI OCIENCES . 2TS ; § S 3 le "Naminaton's Pharmaceutical SCIENCES FRS IOGO QT Lai f re found ir QF EXampbie NEMNQION'S PFIAIMACSUTCAI OCIENCES . 2

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MDOSKK 1 pargniaral aan OU CALERSS Ia) eas na We WANING, $ 3 XMDOSKK 1 pargniaral aan OU CALERSS Ia) eas na We WANING, $3X

COMPOSING TOT Oarsmara fQminisirauiiy Hay + 3 3COMPOSING TOT Oarsmara fQminisirauiiy Hay + 3 3

SITTIN X SSITTIN X S

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OF SE, DOIVSIKYIONS LYS, SUL Qe) ¥ 3 ANOF SE, DOIVSIKYIONS LYS, SUL Qe) ¥ 3 AN

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GUN, Qi NEN ASIN ERTS HESS 3 > > = = > nd od an x N N © N A an pe ~ © en AR An pas SAN ? Isis Ar aoimaers can he sen ~ ened x NNER TENS NN IA YA Scanner Sy an he used lsctide/givrotide copolymers, or DOIVOXVEUTYISNS-DOIVOXYDTODVIETIE LU SUIYTEIGN SO Lath) CS Ladd 4 SOTO QI LS LUVDINTTIOHD, LI PUY LAYRUNNIENES +» y y; X S 3 XGUN, Qi NEN ASIN ERTS HESS 3 > > = = > nd od an x N N © N A an pe ~ © en AR An pas SAN ? Isis Ar aoimaers can he sen ~ ened x NNER TENS NN IA YA Scanner Sy an he used lsctide/givrotide copolymers, or DOIVOXVEUTYISNS-DOIVOXYDTODVIETIE LU SUIYTEIGN SO Lath) CS Ladd 4 SOTO QI LS LUVDINTTIOHD, LI PUY LAYRUNNIENES +» y y; XS 3X

IQ ECTS AGENTEN WAYS, > > $ Age $ = {+ x ~ A “3 J | Aafians ovuelanse $ $ foils rom area daffisaunes watame eut AAN reat nay X ; leliyeryv sy ams $ cantrol tha ralaaca of the COMPAUNGSE, ang DOTSITISHV USE MRTG MURVE Y SY ol > 10 CONTTOI INE lEIDaSS OT INS MAS MIRE KES ; 3 & a & x ai ee ea sl acatata Sanabıımar : ; x ie athviene vinyl acetate DONC Sf + $ oy Fie SF TPE EY amoaunds for evamnias includes ath SENS VI abttait LU ANTENNENIQ ECTS AGENTS WAYS, > > $ Age $ = {+ x ~ A “3 Y | Aafians ovuelanse $ $ foils rom area daffisaunes watame eut AAN reat nay X ; leliyeryv sy ams $ cantrol tha ralaaca of the COMPAUNGSE, ang DOTSITISHV USE MRTG MURVE Y SY ol > 10 CONTTOI INE LEIDASS OT INS MAS MIRE KES ; 3 & a & x ai ee ea sl acatata Sanabıımar : ; x ie athviene vinyl acetate DONC Sf + $ oy Fie SF TPE EY amoaunds for evamnias includes ath SENS VI abttait LU ANTENNEN

Ar theraneutie a HISDrION CONIDOUNGS, Tor © CAT II RENE, EEE KLEE > toi LIL RAE. LT MERA LAAN IAA 3 ; ee sons eat ian ue no en N om bn bend Das retame and innanmeas 43 A Veen AN ea Da cet amis. and inosomes, ticles ISITIONS DUT HTISMANtaDIS HTUSION systams, ang ASSO =Ar theraneutie a HISDrION CONIDOUNGS, Tor © CAT II RENE, EEE KLEE > toi LIL RAE. LT MERA LAAN IAA 3 ; ee sons eat ian ue no en N om bn bend Das retame and innanmeas 43 A Veen AN ea Da cet amis. and inosomes, ticles ISITIONS DUT HTISMANtaDIS HTUSION systams, ang ASSO =

DAMICISS, OSMAOUC DUNIDS, mdianiadia HTUSION y : }DAMICISS, OSMAOUC DUNIDS, mdianiadia HTUSION y : }

DartiCiSE, LÉ DIT ISSUES RAUNT, TTT a ethene srr a et ie et es hs 8 TN LT Le alatas a à nharmanspentisal ssnimesneitinn a > = ï i 7 the pre ait invention also relais: © à pharmacteuticai LAS SHIQE, aDartiCiSE, LÉ DIT ISSUES RAUNT, TTT a ethene srr a et ie et es hs 8 TN LT Le alatas a à nharmanspentisal ssnimesneitinn a > = ï i 7 the pre ait invention also relays: © à pharmacteuticai LAS SHIQE, a

Ï ii HHS, INS Fossey HVE ai VAS Wd RELA INNA ÿ in other embodiments He Drogen HVENTION SISO FSIRIES to a 3 ;Ï ii HHS, INS Fossey HVE ai VAS Wd RELA INNA ÿ in other embodiments He Drugs HVENTION SISO FSIRIES to a 3 ;

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According to a preferred embodiment of the present invention, a method for determining treatment or prophylaxis of à viral infectious disease, or in à pharmaceutical composition according to the invention is used, said method comprising the following steps Ee) {a} determining the amino acid sequence(s) from at least one vival genome, preferably for part of the viral epitopes), with those of at least one other related virus {preferably of the same family, moreAccording to a preferred embodiment of the present invention, a method for determining treatment or prophylaxis of a viral infectious disease, or in a pharmaceutical composition according to the invention is used, said method comprising the following steps Ee) {a} determining the amino acid sequence(s) from at least one living genome, preferably for part of the viral epitopes), with those of at least one other related virus {preferably of the same family, more

SO preferably from the same species) and determining the conserved regions in the viralSO preferably from the same species) and determining the conserved regions in the viral

FMOR GmbHFMOR GmbH

PRC-O007-PLU 28.02 2023 Luxemburgische PalentanmaldungPRC-O007-PLU 28.02 2023 Luxembourg Palentanmaldung

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LU103079 complaxes and/or matching to Bealls, preferably Delonging to conserved viral epHone 8 praferably selected according fo {© and determining the physiological and physicochemical properties, ; Ai composition of at lsast ons, more specific at least two, more preferably at {8} creating à composition of at least ong, More Specific at least twa, mora pi \ to (ci), while considering HLA allele distribution of the worldwide population,LU103079 complaxes and/or matching to Bealls, preferably Delonging to conserved viral epHone 8 preferably selected according to {© and determining the physiological and physicochemical properties, ; Ai composition of at lsast ons, more specific at least two, more preferably at {8} creating à composition of at least ong, More Specific at least twa, mora pi \ to (ci), while considering HLA allele distribution of the worldwide population ,

According fo one especially preferred smbodiment of the present invention, a method for determining pharmaceutically active HLA antigenic peptides and/or antigenic poïvpepides for aspeacially preferably at least four, most preferably up to five different viral infectious dissase(s), viral infectious dissase{sigenome, preferably for paris of the proteome expressed on the viral surface proteins, more preferably being a part of the viral epitope(s), of ‘bY comparing the amine acid sequence(s), preferably those determined according to (8), {3} COMPAanng INS amine adil SSOQUENCE(S}, prareradly MOSS ag i 4 3 with those of at least ons other related virus per selected genomes of (8) (preferably of same genus, most preferably from the same species) and determining the conserved regions in {he viral genomes, {6} determining amine acid sequence(s) corresponding to MHC class | and/or class N region(s), more preferably those determined according to (bi,According to one especially preferred smbodiment of the present invention, a method for determining pharmaceutically active HLA antigenic peptides and/or antigenic poïvpepides for aspeacially preferably at least four, most preferably up to five different viral infectious dissase(s), viral infectious dissase{sigenome , preferably for paris of the proteome expressed on the viral surface proteins, more preferably being a part of the viral epitope(s), of 'bY comparing the amine acid sequence(s), preferably those determined according to (8), {3 } COMPAanng INS amine adil SSOQUENCE(S}, prareradly MOSS ag i 4 3 with those of at least ons other related viruses per selected genomes of (8) (preferably of same genus, most preferably from the same species) and determining the conserved regions in {he viral genomes, {6} determining amine acid sequence(s) corresponding to MHC class |. and/or class N region(s), more preferably those determined according to (bi,

PR aed 28.02 2023 Luxemburgische PalentanmeldungPR aed 28.02 2023 Luxembourg Palent Registration

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In an especially preferred embodiment of the invention, at least two amino acid sequences that match HLA antigen peptides are selected to match conserved regions in the viral opitope that encode different proteins. In a particularly preferred embodiment, at lsast two of these amino acid sequences are combined In an antigen polypeptide such that the sequences contained encode differant profes in the virus, 150 In a preferred smbodiment of the present invention, novel viral variants, such as a mulant antigen peptides according to the present invention can be compared to predict whetherIn an especially preferred embodiment of the invention, at least two amino acid sequences that match HLA antigen peptides are selected to match conserved regions in the viral opitope that encode different proteins. In a particularly preferred embodiment, at least two of these amino acid sequences are combined In an antigen polypeptide such that the sequences contained encode different profes in the virus, 150 In a preferred embodiment of the present invention, novel viral variants, such as a mulant antigen peptides according to the present invention can be compared to predict whether

Mulations alter the amino acid sequence in the conserved regions, Thus, potential resistance to immunization can de predicted and evaluated in silico. conserved regions as identified, for example with means described in 5), can be analyzed ioMulations alter the amino acid sequence in the conserved regions, Thus, potential resistance to immunization can be predicted and evaluated in silico. conserved regions as identified, for example with means described in 5), can be analyzed io

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Any means known to the skilled person can be used, preferably the use of the online servers prediction is performed using al least two, preferably three, and most preferably four of the affinities may vary between the different methods, In a preferred embodiment of the present an acciiracy of the AA! mide! in mmstehirne 9 none fa the antnane\ In an oavan mare nreferrect! sv ALLAH ALY VI OS RRL THULE I TG à NOPOLIC AG VS SPREE HE CSI SEVEN HIDE MITTEN émbodiment, a portion of the conserved region with a score of C5 and higher is considered aAny means known to the skilled person can be used, preferably the use of the online servers prediction is performed using at least two, preferably three, and most preferably four of the affinities may vary between the different methods, in a preferred embodiment of the present an accident of the AA! mide! in mmstehirne 9 none fa the antnane\ In an oavan mare nreferrect! sv ALLAH ALY VI OS RRL THULE I TG à NOPOLIC AG VS SPREE HE CSI SEVEN HIDE MITTEN émbodiment, a portion of the conserved region with a score of C5 and higher is considered a

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EN cod ed i hoantinas ara oranstast bi Hon, artificial tandem polypeptides are createdEN cod ed i hoantinas ara oranstast bi Hon, artificial tandem polypeptides are created

Fi vent invention, artificial lande SONDERN bodiment of the current invention, artificial | DON 8) in one embodiment of the current inven ; 3 O SA crie GRINS co … ; mLhaniee mashing farming : SES USING aN H-NOUSE MECNING MWST igFi vent invention, artificial lande BUT Bodiment of the current invention, artificial | DON 8) in one embodiment of the current invention ; 3 O SA crie GRINS co… ; mLhaniee mashing farming : SES USING an H-NOUSE MECNING VAT ig

HLA alleles coverages, using an in-house ma toh B-cell and T-cells and HLA allsies co YSIAgé, USING matching 5-06 and 1-ealis and HL AHLA alleles coverages, using an in-house ma toh B-cell and T-cells and HLA allsies co YSIAgé, USING matching 5-06 and 1-ealis and HL A

ISLE SSSR SI ; or oe ; i } verifying the results with in vivo feedback, In ét = nogenioïy and varifving the results with in vivo fISLE SSSR SI ; or oe ; i } verifying the results with in vivo feedback, In ét = nogenioïy and varying the results with in vivo f

BAL) 4h to predict the immunogenicity and verifying the res {ML} approach to predict the immun AST \ {MALE AG GAL) $ | : Co _ N does avanti men le Seer 3 AO ti N improved by feedback from in vive © a ML is thus continuously improved MY QQ Rai ferred embodiment, the MU is thus continuously ATH \ & proferrad emboonnent, US AL IS 02BAL) 4h to predict the immunogenicity and verifying the res {ML} approach to predict the immune AST \ {MALE AG GAL) $ | : Co _ N does avanti men le Seer 3 AO ti N improved by feedback from in vive © a ML is thus continuously improved MY QQ Rai ferred embodiment, the MU is thus continuously ATH \ & proferrad emboonnent, US AL IS 02

Creme 3 3 nrandietant ; i u NIE a Ta TaN aoictee ; { EHISA Tha imimumanenie &HHTODES praqiciad i s elispot and ELISA. The HULL SR Ä \ snicity studies such as QUSROT ang lisa, In \Cream 3 3 nrandietant ; i u NIE a Ta TaN aoictee ; { EHISA Tha imimumanenie &HHTODES praqiciad i s elispot and ELISA. The HULL SR Ä \ snicity studies such as QUSROT ang lisa, In \

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ML model since the b GATTAT AIR nariML model since the b GATTAT AIR nari

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Ï tide of the invention is immunogenic or not whaethar a DONDEDHOS OT ING IVSITHON IS mmu uÏ tide of the invention is immunogenic or not whaethar a DONDEDHOS OT ING IVSITHON IS mmu u

WISINST à BONDSDUOS © } i rodenicitv of an antigen al of the immunogenicity of an antigen invention, the prediction of the immunogenicity of an antig } iment of the currant invention, the pradiction of x , embodiment of the current invention 1h in one embodiment of the currant inv ; { oeWISINST à BONDSDUOS © } i rodenicitv of an antigen al of the immunogenicity of an antigen invention, the prediction of the immunogenicity of an antigen } iment of the current invention, the prediction of x , embodiment of the current invention 1h in one embodiment of the current inv ; { oe

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AIT The rot | oe BUT ti ti prafarably has an accouracy of at i th the current invention praferably has an agourag y i JHE nodel in accordance with the current invention rere X trained ML mode! in accordance with theAIT The red | oe BUT ti ti prafarably has an accuracy of at i th the current invention praferably has an agourag y i JHE node in accordance with the current invention rere X trained ML mode! in accordance with the

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Sa fives can he reduced compare acl t, the number of false positives can be reduced compared ; : fembadimeant the number of false nositives à : ; safarras armas ire oe HS PRI WY 3 45 in à particuiariy preferred emooTONt, Ing nun 45 BEE DEINES TI PIGTOITGE | ; oe ih HE 8 Dar Lu, mn © trot He results with ciassical { is | bsequentiy controlling the results with classical à Hot } nathods by [USS LITTLE LRAT ENR yy QC 5 = Nel aol Tan ano Carnot mate an DY SUOSSQUET N 3 to standard binding prediction msthods VS 3 10 SIanNtard gnaing DISC 0 mu nn. Nn { sas oy oo mat MOY WNSa fives can he reduced compare acl t, the number of false positives can be reduced compared ; : fembadimeant the number of false nositives à : ; safarras armas ire oe HS PRI WY 3 45 in à particuiariy preferred emooTONt, Ing nun 45 BEE YOUR TI PIGTOITGE | ; oe ih HE 8 Dar Lu, mn © trot He results with ciassical { is | bsequentiy controlling the results with classical à Hot } nathods by [USS LITTLE LRAT ENR yy QC 5 = Nel aol Tan ano Carnot mate an DY SUOSSQUET N 3 to standard binding prediction msthods VS 3 10 SIanNtard gnaing DISC 0 mu nn. Nn { sas oy oo mat MOY WN

Co © - refarrad accuracy of of feast SN 9 ioulations, thereby achieving 5 preferred ACCUTaCY OF at GEN ; i inching affine CAIQUIATtIoNns, thereby acitievmg a :Co © - refarrad accuracy of feast SN 9 ioulations, thereby achieving 5 preferred ACCUTaCY OF at GEN ; i inching affine CAIQUIATtIonns, thereby acitievmg a:

SHTODSO DINGING SMINRY CRIGLHRNIN ; 3 | © oe means the manrlelSHTODSO DINGING SMINRY CRIGLHRNIN ; 3 | © oe means the manrlel

Vi an smbachimeand WIE Nas i a oraferred SMB me X VI Nata ane id P80 %. Furthermore, in a preferred embodiment, the = ui. KR oud Dat Lits Hon FUTNarMOre. Ti à rofaraihs vais ab lan 30 9%. Furth ; more prefsrabiv WIN at PAST wl i = oT N ET a ovpentides such as hydrophobicity, Qi, . ; artise of the nolvnentioes s UGH 88 AMyüropnh y, i i Ï KR! properties of the DoOvDEDies S 3 i ti SHISOCHEMIQAI D'ODEIrSS OT TMS DONE considers the physicochemical properties of 1 FHVVi an smbachimeand HOW Nas i a oraferred SMB me X VI Nata ane id P80%. Furthermore, in a preferred embodiment, the = ui. KR oud Dat Lits Hon FUTNarMOre. Ti à rofaraihs vais from lan 30 9%. Furth; more prefsrabiv WIN at PAST wl i = oT N ET a ovpentides such as hydrophobicity, Qi, . ; artise of the nolvnentioes s UGH 88 AMyüropnh y, i i Ï KR! properties of the DoOvDEDies S 3 i ti SHISOCHEMIQAI D'ODEIrSS OT TMS DONE considers the physicochemical properties of 1 FHV

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TIDUIS and VUHIPLIS LE { buraische Patentarmeldunes te, Luxemburgische Patentanmaeid ANGTIDUIS and VUHIPLIS LE { buraische Patentarmeldunes te, Luxemburgische Patentanmaeid ANG

Stora 28.02 2023 LuxemburgisetStora 28.02 2023 Luxemburgiset

MIO GSMDH 28.02 2025MIO GSMDH 28.02 2025

DROIT DU 11st Law

PMC-0C07-P-LU possible to quaniify the parameters which are particularly influential in the polypeptids selection, thus allowing for further, step by step improvement of the data,PMC-0C07-P-LU possible to quaniify the parameters which are particularly influential in the polypeptides selection, thus allowing for further, step by step improvement of the data,

One example of such a trained ML model and the correlation between input and output data is shown in Fig, 15, which does represent a fraction of the current invention and is not milled by # In this particular embodiment of the current invention, the BA-rank result fromOne example of such a trained ML model and the correlation between input and output data is shown in Fig, 15, which does represent a fraction of the current invention and is not milled by # In this particular embodiment of the current invention, the BA- rank result from

NeiMH£pan is the highest correlation result compared with the rest of the inputs,NeiMH£pan is the highest correlation result compared with the rest of the inputs,

His therefore an outstanding achievement of the Inventors fo have found that additional factors can be considered using machine learning (ML) to predict immunogeniclly in siico. The antigen polypeptides determined in the previous steps must be processed in the organism and presented to the T-cel! receptors. This has the {echnical effect that the model generated by this approach resembles much more IN vive conditions, where chemistry, such as protonation reactions, precipitations, cleavage of the peptides occur, and thus pure binding affinity batter, safer, and quicker candidats selection and the feedback von vivo studies can directly be fed back into the ML algorithm to further improve the results, in à particular embodiment of the current invention related to the ML model shown in Fig, 15, mhoflurry processing score and mhollurry_presentation_score), number of amino ac properties in the model are the isoelectne point (OA, net charge of the peptide at aM = 5-8 associated with antigen processing (TAP) protgosome information (TAP), cleavage probability at ihe N-terminus (Cie), the combined score of Score, TAF and Cie (comb Score), and ranking which have à high correlation beiween inpul and output include EL Rank, Ba Rank, Rank AL,His therefore an outstanding achievement of the Inventors fo have found that additional factors can be considered using machine learning (ML) to predict immunogeniclly in siico. The antigen polypeptides determined in the previous steps must be processed in the organism and presented to the T-cel! receptors. This has the {technical effect that the model generated by this approach resembles much more IN vive conditions, where chemistry, such as protonation reactions, precipitations, cleavage of the peptides occur, and thus pure binding affinity batter, safer, and quicker candidates selection and the feedback from vivo studies can be directly fed back into the ML algorithm to further improve the results, in à particular embodiment of the current invention related to the ML model shown in Fig, 15, mhollurry processing score and mhollurry_presentation_score), number of amino ac properties in the model are the isoelectne point (OA, net charge of the peptide at aM = 5-8 associated with antigen processing (TAP) protgosome information (TAP), cleavage probability at its N-terminus (Cie), the combined score of Score, TAF and Cie (comb Score), and ranking which have a high correlation between input and output include EL Rank, Ba Rank, Rank AL,

Mmbofurry presentation sonra Comb scoreMmbofurry presentation sonra Comb score

A ER in an aiternative embodiment of the current invention, inpuis may be excluded from the machine learning algorithm to improve the results. Hs a discovery ofthe inventors, that charge input is the less influential in the database decision In some embodiments of the mentionA ER in an aiternative embodiment of the current invention, inputs may be excluded from the machine learning algorithm to improve the results. Hs a discovery of the inventors, that charge input is the less influential in the database decision In some embodiments of the mention

PMCR GmbHPMCR GmbH

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with CTL matching below 1 wears included. The highest weighted factor is the binding affinity © a NOTE faster OT Thoca nrefarres waisniiise factors represent a discovery by the of aNeies nm IL (TAGIOT LEN INSEE DISTEITSC WEICHUNG TRCLONS represen a yo leads to a better modelling of Immune response in à subject. in an especially preferred embodiment of the current invention, amine acid sequences in the poot can be exchanged, if mutations alter the conservative regions of the virus epitope, In an in different compositions while covering a broad selection of the virus profeing, in such a way that à single amino acid substitution in à new viral variant doesnt affect the combination preparation. 15 the antigen polypeptides the most common alleles to cover preferably at more than 85 %, more alleles gre chosen from al least 20 MHC Class | alleles from table 5, more preferably more combination preparation can be used to immunize nearly the worldwide human population, Inwith CTL matching below 1 wears included. The highest weighted factor is the binding affinity © a NOTE faster OT Thoca nrefarres waisniiise factors represent a discovery by the of aNeies nm IL (TAGIOT LEN INSEE DISTEITSC WEICHUNG TRCLONS represen a yo leads to a better modeling of Immune response in à subject. in an especially preferred embodiment of the current invention, amine acid sequences in the poot can be exchanged, if mutations alter the conservative regions of the virus epitope, in an in different compositions while covering a broad selection of the virus profeing, in such a way that à single amino acid substitution in a new viral variant does not affect the combination preparation 15 the antigen polypeptides to cover preferably at more than 85%, more alleles chosen from at least 20 MHC Class | more combination preparation can be used to immunize nearly the worldwide human population, In

Cases amine acid sequences with lower T-cell and/or B-cell scores can be included to improve the robustness and coverage of the combination preparation,Cases amine acid sequences with lower T-cell and/or B-cell scores can be included to improve the robustness and coverage of the combination preparation,

The present invention further comprises a method for preparing à pharmaceutical composition or formulation according to the vention, said method comprising the following SIDE: {a} determining at least one HLA antigen peptides corresponding to MHC class complexes and/or at least one antigen polypeptide expossd on the cell surface of cells af the viral infectious diseasa(s) of the patient or group of patients to be treated havingThe present invention further comprises a method for preparing à pharmaceutical composition or formulation according to the vention, said method comprising the following SIDE: {a} determining at least one HLA antigen peptides corresponding to MHC class complexes and/or at least one antigen polypeptide exposes on the cell surface of cells af the viral infectious disease(s) of the patient or group of patients to be treated having

PMOR GmbH Ma AA anna : axemburische PatentanmeldungPMOR GmbH Ma AA anna : Axemburian patent application

PMOC-OOOT-P-LU 28.02 2023 Luksmourgisone Palontart 4PMOC-OOOT-P-LU 02/28/2023 Luksmourgisone Palontart 4

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SAN ELL EAN Luxemburgische Palentanmaldung aidSAN ELL EAN Luxembourgish Palentanmaldung aid

LU103079 administered fo à person or à group of persons having at least one identical HLA allele and that contains the combination of HLA antigen peptides according to the Invention in the concentration disclosed herein, wherein an HLA antigen peptide represents an informationLU103079 administered fo à person or à group of persons having at least one identical HLA allele and that contains the combination of HLA antigen peptides according to the Invention in the concentration disclosed, wherein an HLA antigen peptide represents an information

T cells (by HLA antigen peptides corresponding to MHC class | complexes) and/or B cells (by this reason, the pharmaceutical composition according to the invention is preferably applied recognize the applied HUA antigen peptides, process this information applied In the form of viruses which present these HLA antigen peptides on their surface. AL least one HLA antigen administration. The expressiorvierm “composition” therefore refers to the provision of at least one HLA antigen peptide and an adjuvant in à pharmaceutical formulation that allows good applicability and includes solutions, in particular injection solutions, concentrates for the preparation of injection preparations, or powders for the preparation of injection preparations. means à paplide sequence that is bound to or immunogenic for the class | MHC complex {in on the cell surface and comprises & heavy chain with 3 domains (af, a2, and a3) and the B2-T cells (by HLA antigen peptides corresponding to MHC class | complexes) and/or B cells (by this reason, the pharmaceutical composition according to the invention is preferably applied recognize the applied HUA antigen peptides, process this information applied In the form of viruses which present these HLA antigen peptides on their surface. AL least one HLA antigen administration. The expressiorvierm “composition” therefore refers to the provision of at least one HLA antigen peptide and an adjuvant in a pharmaceutical formulation that allows good applicability and includes solutions particular injection solutions, concentrates for the preparation of injection preparations, or powders for the preparation of injection preparations. means à paplide sequence that is bound to or immunogenic for the class |. MHC complex {in on the cell surface and comprises & heavy chain with 3 domains (af, a2, and a3) and the B2

Às such, the polypeptides and pharmaceutical composiions of the present invention (as to herein as "viral infectious disease”, “infectious disease”), In general, the "infectious diseases 20 ancdine fraatasd hu annranriats asminiotratinmn of aifker an II À anfinen mantidea ar aAs such, the polypeptides and pharmaceutical compositions of the present invention (as to rein as "viral infectious disease", “infectious disease”), In general, the "infectious diseases 20 ancdine fraatasd hu annranriats asminiotratinmn of aifker an II À anfinen mantidea ar a

SU HIVVOT USE DY ADDrOPNAIS SQMMYHSIYRaUGN OT athée! an mila antigen peptide or a pharmaceutical composition of the invention (and, more particularly, a pharmaceutically effective amount thereof to à subject (Le, & person having the disease or disorder, or at least one symptom thereof, and/or who is at risk of acquiring or developing such disease orSU HIVVOT USE DY ADDrOPNAIS SQMMYHSIYRaUGN OT athée! an mila antigen peptide or a pharmaceutical composition of the invention (and, more particularly, a pharmaceutically effective amount thereof to à subject (Le, & person having the disease or disorder, or at least one symptom thereof, and/or who is at risk of acquiring or developing such disease or

PMOR GmbHPMOR GmbH

PMC-0007-PAU 28.02 2023 Luxemburgische Patentanmeldung oo &PMC-0007-PAU 28.02.2023 Luxembourg patent application oo &

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HY Alfa aR ÈS and/or BO — 90 list some METSrred, DUT nol imiting, axamy 1 NUS oO — DS ania ol FL HS SRG N , U : ir nat DADS ald 4 © 3 & à . a SSAINAtiANn AanAainat SARS Sali ] ; ti fit mvantion for the use as vaccination against SARS-CoV ; f antigen noptides of the invention for the use as VOST ILE EEE EEE VAR"HY Alfa aR ÈS and/or BO — 90 list some METSrred, DUT nol imiting, axamy 1 NUS oO — DS ania ol FL HS SRG N , U : ir nat DADS ald 4 © 3 & à . a SSAINAtiANn AanAainate SARS Sali ] ; ti fit mvantion for the use as vaccination against SARS-CoV ; f antigen noptides of the invention for the use as VOST ILE EEE EEE VAR"

SEQUETICES OF ANIQEN DODUGSS OT ING MVSTION Tor Ie use as à 4SEQUETICES OF ANIQEN DODUGS OT ING MVSTION Tor Ie use as à 4

SEQUETICES OT antigen LefUdes of ing Nvemic & H ¢ Ets mera oamd santos \ > $ SF which is another embodiment of the orasant invention 18 =, gach of which is another embodime WANE DIESEN nvanuon. iQ <, SEC OT WICH IS SPOINESF SIMDONITIONt OF ING praseSEQUETICES OT antigen LefUdes of ing Nvemic & H ¢ Ets mera oamd santos \ > $ SF which is another embodiment of the orasant invention 18 =, gach of which is another embodime WANE THIS nvanuon. iQ <, SEC OT WICH IS SPOINESF SIMDONITIONt OF ING prase

PMCR OmbH aPMCR OmbH a

PMC-C007-P- 28.02 2023 Luxemburgische PalentanmaldungPMC-C007-P- 28.02.2023 Luxembourg Palentanmaldung

PRIC-GCO7-P-LU A008 EVE - iPRIC-GCO7-P-LU A008 EVE - i

FINO ET füFINO ET for

Tieranimal

SEESSEES

> q 5 De os SOY Seale Drala in , SARS-CoV-2 Spike Protein a /> q 5 De os SOY Seale Drala in , SARS-CoV-2 Spike Protein a /

Table 1, SARS-CoV-2 Si Des 1 rn _ SE amend amo | Tarn Dent airTable 1, SARS-CoV-2 Si Des 1 rn _ SE amend amo | Camo dent air

Peptide | tion | Target Proteinpeptides | tion | Target protein

COUT IAE eld : Reaction | Tat guaCOUT IAE eld : Reaction | Act gua

TTsubtvoe | HLA Poptide | ReactionTTsubtvoe | HLA Poptide | reaction

TTT 8 ubtvne AA PO + À i =e i S AEN yu : iTTT 8 ubtvne AA PO + À i =e i S AEN yu : i

A ene Ï N ie : | WEI i ÏA ene Ï N ie : | WEI i Ï

L TTL SOUS | Snecifie Ë } PREG i iL TTL SOUS | Snecifie Ë } PREG i i

Ï Ny x x iÏ Ny x x i

Alien i iAlien i i

Antigen ; i BNantigen ; i BN

VEN 1 een catia Sant FO RAR!VEN 1 a catia Sant FO RAR!

TEA ad ï SEN tea ny 159 1040)TEA adï SEN tea ny 159 1040)

CEANE > ire a conrot ain sd àCEANE > ire a conrot ain sd à

Ae A PRISE © WELTY criteres € Hyconrote { = Ë qu i § Ö DATS a So SOU 3 HY ; ee ITA TREY 1 Cha Hal A SARS. LO \ 6 WE 3 meAe A PRIZE © WELTY criteres € Hyconrote { = Ë qu i § Ö DATS a So SOU 3 HY ; ee ITA TREY 1 Cha Hal A SARS. LO \ 6 WE 3 me

RSS TILFNE CVTLA i 25 2 : AAN df 1 res is = hh pe dr CES AIN = he TES ssonrotein az 1-848)RSS TILFNE CVTLA i 25 2 : AAN df 1 res is = hh pe dr CES AIN = he TES ssonrotein az 1-848)

EEE | nn Le ae TERE AO AA abike giysopi otein €EEE | nn Le ae TERE AO AA abike giysopi otein €

NEN | Lo SEY TTRE EST [Chain À SARS.CoV5 spike gi 1646) tk olga BS + RURASAE IEA ey UT SE 43 ie 2 spike give en 82 8a) ee DU HURRY TT FIKOYGDEL 1854 ibid sal ini]NEN | Lo SEY TTRE EST [Chain À SARS.CoV5 spike gi 1646) tk olga BS + RURASAE IEA ey UT SE 43 ie 2 spike give en 82 8a) ee DU HURRY TT FIKOYGDEL 1854 ibid sal ini]

Ç BC OMS LES Ba Ë Fain GARG AS 2 spike give prof en pei Sn os TRA ER han A QA RS-Coy-2 spi oh 548)Ç BC OMS LES Ba Ë Fain GARG AS 2 spike give prof en pei Sn os TRA ER han A QA RS-Coy-2 spi oh 548)

FE | se ii . Lee ; TREE LNT Loan 283 Chain , nycoprotes PEFE | se ii . Lee; TREE LNT Loan 283 Chain , nycoprotes PE

LAB ns ee ° A i TTT ETI Are ; | 408 58 2 spike: ooo iLAB ns ee ° A i TTT ETI Are ; | 408 58 2 spike: ooo i

Mala ATED 0301 | TLADAGFIX 1198, { EE RE ss = : ONG A Se Lo ; PAIE ID SANS ses atyconroten { peptide (SE © ne Lo + WS ES TTA SR A BAD S-CoV7 spike ah | olMala ATED 0301 | TLADAGFIX 1198, { EE RE ss = : ONG A Se Lo ; PAIE ID SANS ses atyconroten { peptide (SE © ne Lo + WS ES TTA SR A BAD S-CoV7 spike ah | ol

AoA Anger Ps or SE Lu : NN RS EN a Evan Mi wm ir + À SARS ; jen OT # (Argens ponts BEAT . } ART TEA AEE TIES SS {ha Rep OSAoA Anger Ps or SE Lu : NN RS EN a Evan Mi wm ir + À SARS ; jen OT # (Argens ponts BEAT . } ART TEA AEE TIES SS {ha Rep OS

Ti AAT | KOYOVSPTK | 152,82 | Lio ap! a boy VASTE ns A_ASTN RE 240 > hh oe Ss ü : ‘ pie bn a ha } PAUIITE DO Sa snike cire sapratein { (ds (SEC 2 5 : | | is : EET Tan À Ss A > i Sav > sil 2 SV gan pare SED Ki I ; SENT AST ER Rain À ARS-CoV-2 si al 378-256)Ti AAT | KOYOVSPTK | 152.82 | Lio ap! a boy VASTE ns A_ASTN RE 240 > hh oe Ss ü : ' pie bn a ha } PAUIITE DO Sa snike cire sapratein { (ds (SEC 2 5 : | | is : EET Tan À Ss A > i Sav > sil 2 SV gan pare SED Ki I ; SENT AST ER Rain À ARS-CoV-2 si al 378-256)

FAR on PRE EE EE ER ET TR 58 {Chaim À SAR RSR ESFAR on PRE EE EE ER ET TR 58 {Chaim À SAR RSR ES

A = nc Lee NAN EAN y > : A 5 2 aplke g to oe i i = = ; ETL AA 2d 32 : { Y Le N Sr 1 x + X ; i Si me : AS, “53 : = ; i SQ DRO Bd oe Lo A ; CT TUE EA SNe FY cidre Hvcoprote ee Sa Sn i KUN SG à QARSOGV-2 soike aly ;A = nc Lee NAN EAN y > : A 5 2 aplke g to oe i i = = ; ETL AA 2d 32 : { Y Le N Sr 1 x + X ; i Si me : AS, “53 : = ; i SQ DRO Bd oe Lo A ; CT TUE EA SNe FY cider Hvcoprote ee Sa Sn i KUN SG à QARSOGV-2 soike aly ;

Ach Afiger peptide (SEQ 1D ne Lo + EIT TERS {Chan A, SAREDGV er STEOh Afiger peptide (SEQ 1D ne Lo + EIT TERS {Chan A, SAREDGV er STE

Ta he ors FRICOMLK 1588 | Cha se sheen ei x SEX sn : OS HLA-AO3D" Han BEIASHNLT = x N _ hd SR 7 iT Sd | cu nn. Lo ; PAIX en AN AN } quiles © NET t { dus 2 DE } TUE T Chu CoV-7 amike af ‘peptic ES io 13.05) | PA x PT EL a. FE SE ç 3 5Ta he ors FRICOMLK 1588 | Cha se sheen ei amike af 'peptic ES io 13.05) |. PA x PT EL a. 3 5

U nen SE Co : | PLAINES UE IV IY VAS ER à 35 87 | Chain À, ke giycoprot JkU nen SE Co : | PLAINES UE IV IY VAS ER à 35 87 | Chain À, ke giycoprot Jk

Bl fa ; COUPON AL ADanS I NYVNYIVRT : HIRES: i Cava spi RANEBl fa ; COUPON AL ADanS I NYVNYIVRT : HIRES: i Cava spi RANE

Ç | BS | PLA IT : TTT Rn A SER COVE spike glveo protein!Ç | BS | PLA IT : TTT Rn A SER COVE spike glveo protein!

ERE pepe SEE ETERS PRAGA {Tham À SA?ERE pepe SEE ETERS PRAGA {Tham À SA?

LAS Antigen peptide (FO torres oe INT N oC _ > Aa var QYPE : DONE RKS i ;LAS Antigen peptide (FO torres oe INT N oC _ > Aa var QYPE : DONE RKS i ;

Me s (SEQ ID NOS | HLA-527059/ IVELFR ; in tn a PAS ET I ie + { {1 82 i a 'RUCR A fide (SEQ ID NOB | i oo | —Me s (SEQ ID NOS | HLA-527059/ IVELFR ; in tn a PAS ET I ie + { {1 82 i a 'RUCR A fide (SEQ ID NOB | i oo | —

HLA-R Antigen pepiide (SEQ ID NOE) | ä se | oe ' a | HEA id : i een een a ee amie ivconrotain (497-521) ; | HLA-BOSDI i dn SANS soike alvcor ! res ; ARE OR + A AVAL: oV-7 spike g ; ï en ASE 1485 38 i Chain A SAND 0 X 9 EEEHLA-R Antigen pepiide (SEQ ID NOE) | a se | oe'a | HEA id : i een een a ee amie ivconrotain (497-521) ; | HLA-BOSDI i dn SANS soike alvcor! res ; ARE OR + A AVAL: oV-7 spike g ; ï en ASE 1485 38 i Chain A SAND 0 X 9 EEE

NEST | Chain A, 8 SENEST | Chain A, 8 SE

LAA PRY RV fLOF Id 70 ï ETF 1 esseLAA PRY RV fLOF Id 70 ï ETF 1 esse

HRA we Ah MA i . : NTR A NTA U te me nore TAGES Vi oon posts hh. 2 pen KNUT ï Pa TRES 2 SAF SG 8 alyHRA we Ah MA i . : NTR A NTA U te me nore DAYS Vi oon posts hh. 2 pen KNUT ï Pa TRES 2 SAF SG 8 aly

HERR paplids (SEC IP HG 192 | U end OT SEMR paplids (SEC IP HG 192 | U end OT SE

PLAC Sten penis (BEG TR RASA I VOPVRIANA 190 44 - oo + - IPN RRQ Anar 347 I YOPYRY ji ,PLAC Sten penis (BEG TR RASA I VOPVRIANA 190 44 - oo + - IPN RRQ Anar 347 I YOPYRY ji ,

Pe SEQ ID N qi | si 2 tt SS i i i sn sentide (SEQ ID NO 19 | HLA-RSS i | = ks Pager pestis SE © | | 4 : | 431,59 eee ren ‘ _ | Ri ee } TE TA am m m mm mm am m Soite aIvconroteain {497 >Pe SEQ ID N qi | si 2 tt SS i i i sn sentide (SEQ ID NO 19 | HLA-RSS i | = ks Pager pestis SE © | | 4 : | 431.59 eee ren ' _ | Ri ee } TE TA am m m mm mm am m Soite aIvconroteain {497>

Radi : ERI A, SARS-CoV-7 soike ayes be : ASFE( 15908 i Chain A, SARS X meRadi: ERI A, SARS-CoV-7 soike ayes be: ASFE( 15908 i Chain A, SARS X me

SERS TERA SFEI : 250 5 | ES 3 SA os = ; 8SERS TERA SFEI : 250 5 | ES 3 SA os = ; 8

EE je Le … Le rn : INQ eh do a he, FUEL EEN be, rotein : 902-913 }EE je Le … Le rn : INQ eh do a he, FUEL EEN be, rotein : 902-913 }

DO LE oe Lee Lu È EUR TER S Dos anike giyconrotein { 3 peptide (SEQ © en indie = A SUR = AS SI spike givoot äDO LE oe Lee Lu È EUR TER S Dos anike giyconrotein { 3 peptide (SEQ © en indie = A SUR = AS SI spike givoot ä

REA en Lee ; Pesmenmeancae ASE NS vi Ham A BARS ; ‘coprotein 00261REA and Lee ; Pesmenmeancae ASE NS vi Ham A BARS ; ‘coprotein 00261

HLA-B Antigen peptide {wild | mire rer es + - ST EN Re dm | it A AR TOs i y RFNGIGYW | Frein À, SA jen Géatiqie FOREST AC RE | HLA-BZ FamaHLA-B Antigen peptide {wild | mire rer es + - ST EN Re dm | it A AR TOs i y RFNGIGYW | Frein À, SA jen Géatiqie FOREST AC RE | HLA-BZ Fama

POS ARS aptide (SEQ ID NG 1H | | YRENGIGVPOS ARS aptide (SEQ ID NG 1H | | YRENGIGV

CHOATE Antigen peptide {SEQ {IT | HLA-BETOS 13CHOATE Antigen peptide {SEQ {IT | HLA BETOS 13

LHLA-S AY WEEN DS} NEE aELHLA-S AY WEEN DS} NEE aE

Lo PatentanmeldungLo patent application

Le buroische Fatentarenel GLe boroische Fatentarenel G

Luxemburgische FaLuxembourg company

IR 59 2093 23.02.2023IR 59 2093 23.02.2023

PRIOR GraphPRIOR Graph

C10007-EL1C10007-EL1

PMC-C007-F-LU va 1PMC-C007-F-LU va 1

ENEN

En ; 1 id Protein 2 Nucisocaneid Protein _En ; 1 id protein 2 nucisocaneid protein _

SARS-CoV-2 Nucleocapsic eeSARS-CoV-2 Nucleocapsic ee

Tabl 2, S/ NeW E N a _ _Tabl 2, S/ NeW E N a _ _

Taie 2 SAS esse UT Siret | TargTaie 2 SAS esse UT Siret | Targ

SENS, 0 oo wae ML A Po ot de { moat onSENS, 0 oo wae ML A Po ot de { moat on

C0) Subtype HLA PeptideC0) Subtype HLA Peptide

TT ES situ 1TT ES situ 1

He son we | PA 1 X Ÿ XHe son we | PA 1 X Ÿ X

AY A tog MRE | Spanien iAY A tog MRE | Spain i

LA PROT | Specific i i i i | Ÿ / von. | | | menrsesscnnes cms ! | Antigen Ï | i EE [Bar SOFORT i ; i | | ees Sal coro ; | i | frm Seren TE } | tfarin nt i | Er te Soho ! | Variant i memento SET TRS cs i ! A EET 71 NiLA PROT | Specific i i i i | Ÿ / from. | | | menrsessscnnes cms! | Antigen Ï | i EE [Bar IMMEDIATELY i ; i | | ees Sal coro ; | i | frm serums TE } | tfarin nt i | He's in Soho! | Variant i memento SET TRS cs i! A EET 71 Ni

SEF € I | De LE, X i { SASTTESSRANSGET SES [ ARDPON | FPROQOVEI TS | fan. an àSEF € I | De LE, X i { SASTTESSRANSGET SES [ ARDPON | FPROQOVEI TS | fan. to à

Ta UT A-ROTOO/ 1 È 2 aaa ve { N Mt IQ / 89-881 RE ! RR | HLA-BO702/ ; | | HIKUS-ST 80-8 J CONS ISOTa UT A-ROTOO/ 1 È 2 aaa ve { N Mt IQ / 89-881 RE ! RR | HLA-BO702/ ; | | HIKUS-ST 80-8 J CONS ISO

N bentide (SEQ ID NOD-131 } FILAA-N ; | | KU ! III protem {+ : AR Anlloe sou de | > jd aL NV. A 1 ! 4 \ memmmmaemneene OAL re Ean CANE pre + ÏN bentide (SEQ ID NOD-131 } FILAA-N ; | | KU ! III protem {+ : AR Anlloe sou de | > jd aL NV. A 1 ! 4 \ memmmmaemneene OAL re Ean CANE pre + Ï

PUR Antigen peptide {ois ; ae | { sob SES Rome ;PUR Antigen peptide {ois ; ae | { sob SES Rome ;

HLA-B AL Tug Rg } HLA-R3901 i feet SERIE EERE TEHLA-B AL Tug Rg } HLA-R3901 i feet SERIES EERE TE

Pom LAS i renee enna EATS Shan A oy FERED SR TAT A DoS proue X Ÿ i } ESS SEE EERE vsPom LAS i renee enna EATS Shan A oy FERED SR TAT A DoS proue X Ÿ i } ESS SEE EERE vs

TETRA ROTOR 1 KFROKRTAT | bo es eres | HLA-BÜTO2/ KE | La crc i SES AEA TR NSTI PoriLA-n ; i Pas} TRISTE a : ITI 3D NOLTE) ; i | i SERIA TIE Sane prota €TETRA ROTOR 1 KFROKRTAT | bo es eres | HLA-BÜTO2/ KE | La crc i SES AEA TR NSTI PoriLA-n ; i Pas} TRISTE a : ITI 3D NOLTE) ; i | i SERIA TIE Sane prota €

SURE ae npeptce (Sli | ait A_RNAN- : | TEUTRIONNITEE REROUS piecesSURE ae npeptce (Sli | ait A_RNAN- : | TEUTRIONNITEE REROUS pieces

Pd HE ES sys Ta i i BEART ETS ETAPd HE ES sys Ta i i BEART ETS ETA

EMA RE 84 1 KAYNVTQAI | boa mnEMA RE 84 1 KAYNVTQAI | Wow mn

DT A TR Aa H peptide (onl i i mnamn4 | | ess SE ES A TNDT A TR Aa H peptide (onl i i mnamn4 | | ess SE ES A TN

LAA { POA La Q $ AE DUR N X 8 CD NOTE) | HLA FAT CN | Ne a N peptides (SEO iD NG 15 ; x} AAN ; | | ra oo _ a.LAA { POA La Q $ AE DUR N X 8 CD NOTE) | HLA FAT CN | Ne a N peptides (SEO iD NG 15 ; x} AAN ; | | ra oo _ a.

HLA-À Antige N peptide (DE ; | | wa 200HLA-À Antige N peptide (DE ; | | wa 200

Mi a | : ! + Lu te py or ;Mi a | : ! + Lu te py or ;

PORTA > X : ST TE Pur ST | NUCIGOCEI 1 ; a INSTR ONT Pll Ÿ © Ÿ i eee SEY RAST DA Ï SS 1X nnPORTA > X : ST TE Pur ST | NUCIGOCEI 1 ; a INSTR ONT Pll Ÿ © Ÿ i eee SEY RAST DA Ï SS 1X nn

NET HABER | METRE | Anoot (215-2583 anNET HABER | METERS | Aroot (215-2583 on

SEO A Ha Ï VEY mal 31 Lee PE or © ; ) ) _ | | | Tr fe IRA R © DOI ONAVITLISSEO A Ha Ï VEY times 31 Lee PE or © ; ) ) _ | | | Tr fe IRA R © DOI ONAVITLIS

RE NY | A Ï ; ALSO I ARAERC MSR | ALRE NY | A Ï ; ALSO I ARAERC MSR | AL

TRAIT ASAFFGMS! { Va sim anandTRAIT ASAFFGMS! { Va sim anand

PNG B N Ö N Eu | Yan ASE De NPNG B N O N Eu | Yan ASE De N

EOS a XV ee odEOS a XV ee od

TOT RR A is an DE DUO NEE Na i i | a EEE USETOT RR A is an DE DUO NEE Na i i | a EEE USE

SLA-A Antigen KAMEN ; ; N SEES SriSLA-A Antigen CAME ; ; N SEES Sri

FLAS : x i : ear _ mesa ; + TTL X i APR TYR hii ; i bee TERT : X eb SASSFÉ ErFLAS : x i : ear _ mesa ; + TTL X i APR TYR hii ; i bee TERT : X eb SASSFÉ Er

SEQ ID NOUS HILA-ACSU | = on ooSEQ ID NOUS HILA-ACSU | = on oo

N Anticer fick {oid AEN J i sos oo | _ _ l'HLAA A ntigen pentide (SEO ML Noté | Jon te © hE or HLA-AOGE 5 ! | i] hin iN Anticer fuck {oid AEN J i sos oo | _ _ l'HLAA A ntigen pentide (SEO ML Noté | Jon te © hE or HLA-AOGE 5 ! | i] hin i

Ri | HLA-AZUGT | etRi | HLA-AZUGT | et

REET Qo a Vf 2 45REET Qo a Vf 2 45

ARTERY 1 AGFAPSABA | 82.48ARTERY 1 AGFAPSABA | 82.48

O20 | HLACETSOT ee | {Adie 0O20 | HLACETSOT ee | {Adie 0

Fee 8 a 8 a i | Ÿ VITE LL ! HLA-R Antigen ne SS { | | I ; . | ı i EnFee 8 a 8 a i | Ÿ VITE LL! HLA-R Antigen ne SS { | | I ; . | ı i En

A nn i a ...A nn i a ...

À > i Banner banane aÀ > i Banner banana a

AA

AD nd 23.02.2023AD nd 23.02.2023

SENT CireiinidSENT Cireiinid

PRICK GmbhPRICK GmbH

C10007-EL1C10007-EL1

PMC-C007-F-LUPMC-C007-F-LU

Tate 3 SARSONU.? Envelone DratainTate 3 SARSONU.? Envelone Dratain

Table 3, SARS-CoV-2 Ervelose ProteinTable 3, SARS-CoV-2 ervelose protein

AU OR ES ES EE TE I Prestair } me ee TE LMD A DantiSe | Dasrtine | Target Frotein :AU OR ES ES EE TE I Prestair } me ee TE LMD A DantiSe | Dasrtine | Target protein:

I LA ISOTYHE 1> = ; $ i : ; : i ! ; ! 1 1 Ï fe 1 5 San 1 : : | Specific ; : WEIS : ! ! | SPGGIS ; VaR i ! i ; i ; iI LA ISOTYHE 1> = ; $ i : ; :i! ; ! 1 1 Ï fe 1 5 San 1 : : | Specific ; : WHITE : ! ! | SPGGIS ; VaR i! i ; i ; i

Antisen i : ! ; i | ANVGEN- i i i i i X ee : i i ! ; i ! i ; i ; bony anti i : ! 1 aviary i iAntisen i : ! ; i | ANVGEN- i i i i i X ee : i i ! ; i! i ; i ; bony anti i : ! 1 aviary i i

Variant i i ; AAVariant i i ; AA

A i A N - SENSE mmnnmennnnnnennannennnnnnannndunnnnnnnannannenes : DES Ha clone nrofein ISARS-Cot-21 40.75 : A - er ae ET PN AAN à ! envelope protein TSARS-OaV-21 2 F0) }A i A N - SENSE mmnnmennnnnnennannennnnnnannndunnnnnnnannannenes : DES Ha clone nrofein ISARS-Cot-21 40.75 : A - er ae ET PN AAN à ! envelope protein TSARS-OaV-21 2 F0) }

HLA-A Antigen peptide (SER ID NOU2TE | HLAAD 1 ; : rene ! = ? A meseeeeee eee esse e nee dMe ane s case nee sense ane S eee een S anna CUVE EE RINT ETRE i : RO l SRVOIONS arotein SAREE HERSEY ;HLA-A Antigen peptide (SER ID NOU2TE | HLAAD 1 ; : rene ! = ? A meseeeeee eee esse nee dMe ane s case nee sense ane S eee een S anna CUVE EE RINT ETRE i : RO l SRVOIONS arotein SAREE HERSEY ;

RR RII IIIT IRE TEE TERY i A AQDOT | SLVKPSFYV 1911 PENVRIOPRR DIOISIN [DS AMD- LO Wed (RD) !RR RII IIIT IRE TEE TERY i A AQDOT | SLVKPSFYV 1911 PENVRIOPRR DIOISIN [DS AMD- LO Wed (RD) !

HLA-A Antican nentide (SEO ID sel! PLA ALT | : ! esHLA-A Antican nentide (SEO ID sel! PLA ALT | : ! es

PLACA ANDGEN DODIGE {Sid IA : | : : TT a TE TE ETT i merde ee N TT TR RS FOUT Tae SE Ï ere bbs | emvelope protein [SAR S-GOV-2] (40.75) ;PLACA ANDGEN DODIGE {Sid IA : | : : TT a TE TE ETT i merde ee N TT TR RS FOUT Tae SE Ï ere bbs | emvelope protein [SAR S-GOV-2] (40.75) ;

HLA-A Antigen SOPULE {oT I NULLS POET : fi PE PETITE i > i TIC To a ER Br EE Ir Er Bae ; spin FOARSLOAV.DY ALTEN } 1 ——_--__—-—-- - - _ _— _ -————"" er ET COQ 1 45 54 | ENVEIODE protein [SARS-CoV-2] (49-751 }HLA-A Antigen SOPULE {oT I NULLS POET : fi PE PETITE i > i TIC To a ER Br EE Ir Er Bae ; spin FOARSLOAV.DY ALTEN } 1 ——_--__—-—-- - - _ _— _ -————"" er ET COQ 1 45 54 | ENVEIODE protein [SARS-CoV-2] (49-751 }

TITAS Anfinen Deniide (REQ ID NG 24 À -B1501 | LVKRSFEYWY : 14,11 | ENVEIORE PIGION [SAKS-LGV-AT À ’ ÏTITAS Anfinen Deniide (REQ ID NG 24 À -B1501 | LVKRSFEYWY : 14.11 | ENVEIORE PIGION [SAKS-LGV-AT À ’ Ï

Fo HLA-B Antigen peptide (DIN IL INES RSS [EEA : ; erred } SE TER TE TT A RAR EEE A eee aT | envalone srotein ISARS.CoV-77 (ASI) :Fo HLA-B Antigen peptide (DIN IL INES RSS [EEA : ; erred } SE TER TE TT A RAR EEE A eee aT | envalone srotein ISARS.CoV-77 (ASI) :

PUR AR RU TT EU NR, TP NEN SEN en A-BASGT I NOSRVEDLL 311.84 | GNVEIODS protein {SARS AMT ESP iPUR AR RU TT EU NR, TP NEN SEN en A-BASGT I NOSRVEDLL 311.84 | GNVEIODS protein {SARS AMT ESP i

HT AR Antisan manticda (QED Y NO TS FILA NDS BR bowel vy, ! Ÿ >HT AR Antisan manticda (QED Y NO TS FILA NDS BR bowel vy, ! Ÿ >

DELLA ÄANDGSN Rena {LR I NO 29) {re i : TE ae ! emda ï : red PARQ Nei AD TEA } : Dee I A SO AE TT TT TNA NANTES RAI | DEM SM | ENVEIODE protean FBARS-DaV-Z 1400-70) }DELLA ÄANDGSN Rena {LR I NO 29) {re i : TE ae ! emda ï : red PARQ Nei AD TEA } : Dee I A SO AE TT TT TNA NANTES RAI | THE SM | ENVEIODE protean FBARS-DaV-Z 1400-70) }

PUR A de (SEQ ID NO.7283 | HLA-ROSO! | VVYSRVIENE | 250.80 | ENVEIODE protemn [DARS-CGov- 21 1 }PUR A de (SEQ ID NO.7283 | HLA-ROSO! | VVYSRVIENE | 250.80 | ENVEIODE protemn [DARS-CGov- 21 1 }

HLAR Antisen nentide (SEQ ID NO 265 TILA-RUOUT 1 CVS VIOINE JON : iHLAR Antisen nentide (SEQ ID NO 265 TILA-RUOUT 1 CVS VIOINE JON: i

LHILA-S ANTOEN MERLOT EN i = i : ! erLHILA-S ANTOEN MERLOT EN i = i : ! he

LIL v i { Lu dE NULIL v i { Lu dE NU

PRIOR Gari Luxemburgische PatentanmeldungPRIOR Gari Luxembourg patent application

PMOR Gmbh 28.02.2093 Luxembuigische Patent GPMOR GmbH 02/28/2093 Luxembourg Patent G

PMODOOZPALUPMODOOZPALU

Fafa

Dpt Ding ben ia 1 ARS.-CoV-? Surface ProteinDpt thing ben ia 1 ARS.-CoV-? Surface protein

Table 4 SARS A0 A mL sania le CHENTable 4 SARS A0 A mL sania le CHEN

Table 4, SARS-CoV-2 1 on] a N De al ; or 1 MLA Ponti | Raa cian | T QF cet ha Ÿ crier xTable 4, SARS-CoV-2 1 on] a N De al ; or 1 MLA Ponti | Raa cian | T QF cet ha Ÿ crier x

TTT Suh { HLA Feptide | Reaction | gTTT Suh { HLA Feptide | Reaction | G

PS | Subtype | HLA PeptidePS | Subtype | HLA Peptide

HLA Isotype ; ; À Arad i :HLA Isotype ; ; À Arad i :

X Varia 3 : SS = -- TITERS EEE i } Vartant | Ege Fie SINE TRARET iX Varia 3 : SS = -- TITERS EEE i } Vartant | Ege Fie SINE TRARET i

CUTE ERTTTEE | Chain À, Surface Glyooy i : i rd SEY PERS ;CUTE ERTTTEA | Chain À, Surface Glyooy i : i rd SEY PERS ;

TAT AN Arima me dine (SEQ ID NO. 2 ; i DaTAT AN Arima me dine (SEQ ID NO. 2 ; i Da

Po N X X N yo tee ee SORT RTE ; ; : ; \ mumeneennenne nee n een n mn ns ry Ten IERES COUR : TER À, Surface Glycoprotein [RARS-CoV-2 1 : | REITER Si | Chain A Sur HS NENNT FLAS X X i X tessa, PESTE ÉRIC ES \ i ma TO RENE MESURE PETER i eae res SENS ;Po N X X N yo tee ee SORT RTE ; ; : ; \ mumeneennenne nee n een n mn ns ry Ten IERES COUR : TER À, Surface Glycoprotein [RARS-CoV-2 1 : | RIDER Si | Chain A Sur HS CALLS FLAS X X i

TRE ANGE PSG de (SEG ID NG. ZS) | HLA-HS801 jis i Pras nom iTRE ANGE PSG de (SEG ID NG. ZS) | HLA-HS801 jis i Pras nom i

FLA AUS Adin JEN DEOUQSE {old IL) NG LE ; i | ; | ronFLA AUS Adin JEN DEOUQSE {old IL) NG LE ; i | ; | ron

PLAST Antigen peptide { i | ; | (072-088) 0 ] N ace i Heenan { i rane eee eee emburgische PatontsnmeldungPLAST Antigen peptide { i | ; | (072-088) 0 ] N ace i Heenan { i rane eee eee emburgische Patontsnanmeldung

Luxemburgische Pate 28.02.2023Luxembourgish godfather 28.02.2023

PRIOR GraphPRIOR Graph

PMC-C0O07-FLU ia mney mmm ; mmm mmm mmm mmm - TE - 2 ; fi a - = 5 2 QRFiab Protein mmm mmm ï eat Ses a SV OBRFial mmm ci TE 5, SARS-Cov- ! esse À see “ai baden £ SAN mmm mes - ST BERPMC-C0O07-FLU ia mney mmm ; mmm mmm mmm mmm - TE - 2 ; fi a - = 5 2 QRFiab Protein mmm mmm ï eat Ses a SV OBRFial mmm ci TE 5, SARS-Cov- ! esse À see “ai baden £ SAN mmm mes - ST BER

TENS ©, mmm mmm Ti ape 3 R eee SE TH mmm VE oe | 5 mmm mmm 5 | kn mmm mmm mmm I,TENS ©, mmm mmm Ti ape 3 R eee SE TH mmm VE oe | 5 mm mm mm 5 | kn mmm mmm mmm I,

PRIS A lentu ne | Specific KANN 0 } VHPÉGIME mmssssmsssssssssssssssesssssssssssssssssssssssssssssesssssssssssssess | pe u nn ne a —— RET } | i : A FOREST } ; tea i : | TERRA RINIET 744881 } i nie 3 i i Ann SS 17 } ; } : dessertes ee en TRARY } : x i 1 ORFiab FOIVDrôten (o SEES U } i. TN. : LEE SA REET FARA } i 3 | DES jet menmpanceen can CRATE ÿ } | Var A TIE | SEN } } } FSASTSAFV PARES Fancceeceecee 5 polynratein IRANIAN ha } 1 Pp | TSÂASIDA ! morte RFiab MAS TES ANT TES UE 5 } ETS ATO Ul | seu | aes 5 } SNS IHLA-AUTO i ERREURS ol > SOI } SEQ ID NO 28 yo ry AST 185.18 L TRE ANT TERRES #3 17 } fide (SEQ ID NO 622 pesmepageme een Sean EASY FRE | EEPRIS A lentu ne | Specific CAN 0 } VHPÉGIME mmssssmsssssssssssssssssssssssssssssssssssssssssssssssssssssssssss | pe u nn ne a —— RET } | i : A FOREST } ; tea i : | TERRA RINIET 744881 } i nie 3 i i Ann SS 17 } ; } : desserts ee en TRARY } : x i 1 ORFiab FOIVDrôten (o SEES U } i. TN. : LEE SA REET FARA } i 3 | DES jet menmpanceen can CRATE ÿ } | Var A TIE | SEN } } } FSASTSAFV PARES Fancceeceecee 5 polynratein IRANIAN ha } 1 PP |. 3 17 } fide (SEQ ID NO 622 pesmepageme and Sean EASY FRE | EE

A TT 1 Hentirles {St a ERT RA I LASFDAS i TTR Fab Polyprote I NITRA LaA TT 1 Hentirles {St a ERT RA I LASFDAS i TTR Fab Polyprote I NITRA La

PIAA ADUGESN DE ; nannn N | HLA-AOZD1 i ET RAE TS = l'EPIAA ADUGENS DE ; called N | HLA-AOZD1 i ET RAE TS = l'E

PILA-A X FAT MAN TS nN SO X as N EERPILA-A X FAT MAN TS nN SO X as N EER

AA Antice 4 pestide (QED ID NG.30) } ÉIRETUTETET STSAF | 805 [Ee i } ntide (SEO ! 3 ~ 2) 1 SESASTSAF : ccssseses see TANAA Antice 4 pestide (QED ID NG.30) } ÉIRETUTETET STSAF | 805 [Ee i } ntide (SEO ! 3 ~ 2) 1 SESASTSAF : ccssseses see TAN

RR ican nentide ITA Sa AAN DDP | | VENEN 35-540) iRR ican nentide ITA Sa AAN DDP | | VEINS 35-540) i

Pl ALA à Tiger pet STATE ti A-AS40T | _ a Lu ;Pl ALA à Tiger pet STATE ti A-AS40T | _ a Lu ;

TL > SERIE NO CA PLT | 1 } crepeeeennesseeees HEN REE } EE EE Wl NOT) i aT] 3 | monter Bway prate { fre À Antigen ne pude (DE Puan 1501 ; i namen een | ORFiab MAE ere = ! Hi AA Augen De | PFILA-RTOC } Sirti Sa i Rr: 3 PATL > SERIES NO CA PLT | 1 } crepeeeennesseeees HEN REE } EE EE Wl NOT) i aT] 3 | monter Bway prate { fre À Antigen ne pude (DE Puan 1501 ; i names een | ORFiab MAE ere = ! Hi AA Augen De | PFILA-RTOC } Sirti Sa i Rr: 3 PA

PLAS Pl a. SAYRSIF [994 | TEE SARE - res mmsssemsssssssssssssssssssssssssssissssssssssssssssssssssessses: ses EE polyproteir _- messes sesPLAS Pl a. SAYRSIF [994 | TEE SARE - res mmsssemsssssssssssssssssssssssssssssssssssssssssssssssssssssss: ses EE polyproteir _- messes ses

ABER | AARVY RON ! RF1abd nolvprotelr X } Ti 0707 PARMA | |ORFiab | ot ERRBUT | AARVY RON! RF1abd nolvprotelr X } Ti 0707 PARMA | |ORFiab | ot ERR

SÉQID NG ES | HLA-BOTG : M [D 495 | tein (SARS-Go Well} i } SES ID NO.-32 ; : PONT mea NS DA deseenseseesss ses erie (SARSSÉQID NG ES | HLA-BOTG: M [D 495 | tein (SARS-Go Well} i } SES ID NO.-32 ; : PONT mea NS DA deseenseseess ses erie (SARS

Antigen atide {SEQ TON X On TP QLFRGWILIN 1 RP {ab sohnrotea AM sseeeeeee } ; ary Ë US DUT 1 Pon » polyprotein (3 GorAntigen atide {SEQ TON X On TP QLFRGWILIN 1 RP {ab sonrotea AM sseeeeeee } ; ary Ë US DUT 1 Pon » polyprotein (3 Gor

Antigen nentide A FT ev : | or | a /Antigen nentide A FT ev : | or | a/

PE à Antigen pes en hn RR | 7 = onPE à Antigen pes en hn RR | 7 = on

HLA-B An x Ï Tey AN } FILE 1 Af ARDY RA | CRO SANS. EES SrHLA-B An x Ï Tey AN } FILE 1 Af ARDY RA | CRO SANS. EES Sr

POLS QED NOE +; } TTA NT FFOW! 450.83 EE pros SAR: } ide (SEG ID : = IQASLFFOVV i EE D polyprotein ; ARS-LC a : ou nantes (5 2 AAT PAGES OL : asus, | ORFian POV IS DA A ©POLS QED NOE +; } TTA NT FFOW! 450.83 EE pros SAR: } ide (SEG ID : = IQASLFFOVV i EE D polyprotein ; ARS-LC a : ou nantes (5 2 AAT PAGES OL : asus, | ORFian POV IS DA A ©

TULA aa gen peptic \ Pl A CATA y {+ drersessenees | GRIS rma: TTR —— ! HLA-ÀA Anti SSH} TA AUCY RAA | HLA-A7407 3 COE ann UT ES 15 iv SES EEE ;TULA aa gen peptic \ Pl A CATA y {+ drersessenees | GRIS rma: TTR —— ! HLA-ÀA Anti SSH} TA AUCY RAA | HLA-A7407 3 COE ann UT ES 15 iv SES EEE ;

Por memmsemmnsenanee en NAA Fro = | rn } fide (SEQ ID NO.3 ; ; BRUT RSI SES BMW afr Ra olvorotein (SARS-Co\By memmsemmnsenanee en NAA Fro = | rn } fide (SEQ ID NO.3 ; ; BRUT RSI SES BMW afr Ra olvorotein (SARS-Co\

A Antinen bentide (SEN TEE x nEGNn4 | ASLPFFGY i TR RFiad Poyprole X SEA Antinen bentide (SEN TEE x nEGNn4 | ASLPFFGY i TR RFiad Poyprole X SE

AA Antigen nentioe anne HLA-BSSO1 ; meme PATTER TERNS TTAA Antigen nentioe anne HLA-BSSO1 ; meme PATTER TERNS TT

POY ALA TROT DT anmrmanan, SEX | HHLA-RDE ; en PERS 4 4 | Semmes SEAPOY ALA TROT DT anmrmanan, SEX | HHLA-RDE ; en PERS 4 4 | Semmes SEA

L HLA-A ANT = EIR AYE : vu TE | roms 1 VILA HEAR ES I NO be X N OL 1 eee SR (RARE } ann. tl (Qu: NU! J nnn: EET sh pc } mesesascsnes entide (SEO ID 1 X an ; Te UAGHHLOR i NTRS TTREET Spolprotai àL HLA-A ANT = EIR AYE : vu TE | roms 1 VILA HEAR ES I NO be

H À = ‘ i. "ie = = y IE Hi A-AGTN1 ; bn CATA PSN LR AD 4H À = ‘ i. "ie = = y IE Hi A-AGTN1 ; bn CATA PSN LR AD 4

LA ANUHEN | A Ma. 5 | | oo | À me 11 (SEO ID NO.-37 ; ; i i Hemme } mmm pra TEN or | ot : me : EI DEBUG (D Den ; 1 me a } | Hu oY i bee ~ | LAR me om i Lt à mmm mm a, NORTE > D man A che Patentsnmeldung 3 3 MEUTGISCHE Fatenta nme iiungLA ANUHEN | A Ma. 5 | | oo | À me 11 (SEO ID NO.-37 ; ; i i Hemme } mmm pra TEN or | ot : me : EI DEBUG (D Den ; 1 me a } | Hu oY i bee ~ | LAR me om i Lt à mmm mm a , NORTE > D man A che patent application 3 3 MEUTGISCHE Fatenta name iiung

LuxemburgiecLuxemburgiec

SR ND ADSR ND AD

23.02.2023February 23, 2023

CODECODE

PMOR Gmbh fe Q07-FLLUPMOR Gmbh fe Q07-FLLU

PMC-0007-FL0PMC-0007-FL0

> sas> sas

MEME

Pains ES EN A EIEN VAN SN can eT en LET AA AR RÉ N AN a mé I àPains ES EN A EIEN VAN SN can eT en LET AA AR RÉ N AN a mé I à

Tahlia 8 {ARE MES enapnifiis WDA antinan nantitaeTahlia 8 {ARE MES enapnifiis WDA antinan nantitae

PREIS 0, GARS-GOV-S SPECT MLA antigen DODIICESPRICE 0, GARS-GOV-S SPECT MLA antigen DODIICES

LMI À antfinen sandals | igentifisatinn Net 1 Tarnet Dratain | Mintshine EnfésneLMI À antfinen sandals | igentifisatinn Net 1 Tarnet Dratain | Mintshine Enfesne

RLA SS! Poptide | MOSITIICATION ND, 1 rargst Frais | Maithing EPHOPS |; soliste ta [Dan AS i | RARES aV.2 i ; related to {Pep NO} i POARS-CoV-E !RLASS! Poptide | MOSITIICATION ND, 1 rargst Frais | Maithing EPHOPS |; soloist ta [Dan AS i | RARES aV.2 i ; related to {Pep NO} i POARS-CoV-E !

AIR AS AND MN Omen NOY - RQ es DR ea MT :AIR AS AND MN Omen NOY - RQ's DR ea MT :

AKIRASANL (21) | SEC-ID NO. BY SE Beal], HTLAKIRASANL (21) | SEC ID NO. BY SE Beal], HTL

PAS ARDS A ATE SON MDN IY RECN AIN HE POR madi RAT :PAS ARDS A ATE SON MDN IY RECN AIN HE POR madi RAT :

To AND AT ; Ld bead AN A La ed SEY hedTo AND AT ; Ld bead AN A La ed SEY hed

ASANLAATK {si} DEG-ID NO. 60 Be SCO THE ;ASANLAATK {si} DEG-ID NO. 60 Be SCO THE ;

DO ANDREA UN Omen NOY CR es PT :DO ANDREA UN Omen NOY CR es PT :

AYRENGIGYW (7) | SEQ-D NO 61 SE OTLAYRENGIGYW (7) | SEQ-D NO 61 SE OTL

FENES ENTMAAD SEA PRET NOY RO las PR rail ;FENES ENTMAAD SEA PRET NOY RO las PR rail ;

DO ESALÄRLSEAAÄKN (19) | SEQ-ID NO 82 Poel 1 CONDO ESALÄRLSEAAÄKN (19) | SEQ ID NO 82 Poel 1 CON

EUR EE EEE fa 0 STAR RAR ES FRS Eee ; } NS LS TRIO PAPA + RAT TE dtd + + SAT EN :EUR EE EEE fa 0 STAR RAR ES FRS Eee ; } NS LS TRIO PAPA + RAT TE dtd + + SAT EN :

LG YF OR CT 2) DESTINE. DO DE DAL ;LG YF OR CT 2) DESTINE. DO DE DAL ;

DOESN CHOSE YL STE LE SSENEN TES ONES A Logan Or 1DOESN CHOSE YL STE LE SSENEN TES ONES A Logan Or 1

EH NOMS 5 1 SRI HY NI fe : 25 POT }EH NOMS 5 1 SRI HY NI fe : 25 POT }

PLEO LIN Poonam iS NO. SS Dé PAs !PLEO LIN Poonam iS NO. SS Dé PAs!

LIN STERN IN FAN L'ENITESX ary AIR RE 1 = Vo ee om i à KEANE aan DOANEIOLIMY AS RE Pam Par oo iLIN STERN IN FAN L'ENITESX ary AIR RE 1 = Vo ee om i à KEANE aan DOANEIOLIMY AS RE Pam Par oo i

PLA NAVY EY (eV) SES INK DO LINE HILL ELPLA NAVY EY (eV) SES INK DO LINE HILL EL

Jrmmmentenen nes ten nennnn tn Ann NAN EAU A ANNEE EAN E EE AA tee iit tees EAN UNE EEE A ANNEE EEE A ANNEE CAN annJrmmmentenen nes ten nennnn tn Ann NAN EAU A ANNEE EAN E EE AA tee iit tees EAN UNE EEE A ANNEE EEE A ANNEE CAN ann

L'EST DIVERS SAM DOESN ITS NES AR boone PowayL'EST DIVERS SAM DOESN ITS NES AR boone Poway

PEYVEGRRLM (13) SEC-ID NO. 88 iS HEPEYVEGRRLM (13) SEC ID NO. 88 iS HE

PERS PATES FE as PSS ON AIS OT RD ITER enti :PERS PATES FE as PSS ON AIS OT RD ITER enti :

CN | DELAI NLA OF PN Pony Gen ;CN | DELAI NLA OF PN Pony Gen ;

OREN ETRY BANN SX TOSSES IFR AR DD Es SORT! NTI ;OREN ETRY BANN SX TOSSES IFR AR DD Es SORT! NTI ;

FOFINGVOY (8) | SEC-IS NO. 658 SZ HILL, OTLFOFINGVOY (8) | SEC-IS NO. 658 SZ HILL, OTL

ENTER Tar EN EE TS PARTIR IPN ESTER NS NS iENTER Tar EN EE TS PARTIR IPN ESTER NS NS i

PMWIKI $4 ORAL NITY - AN Pod Po APMWIKI $4 ORAL NITY - AN Pod Po A

FEY ERY GRR (ir; {STAR NO: 69 LAB | LeiFEY ERY GRR (ir; {STAR NO: 69 LAB | Lei

FAs mS RET AA fen ESS GNS NAS SA Tee aT ~~ ;FAs mS RET AA fen ESS GNS NAS SA Tee aT ~~ ;

GYOPYRVVY (6) | SEG-ID NO. 70 ;S2 HILL CTLGYOPYRVVY (6) | SEG ID NO. 70 ;S2 HILL CTL

L'RD\FTONRAT VS EM RES AN + 74 | POT ;L'RD\FTONRAT VS EM RES AN + 74 | POT ;

Poa QNVLY (7) | DEG-ID NO 7/7 LE SENPoa QNVLY (7) | DEG ID NO 7/7 READ SEN

TERT aan TSR DEE IR TEES Poe PER pvTERT aan TSR DEE IR TEES Poe PER pv

KOLSPRAWYEF (20) | SEC-ID NO: 72 NS iHTL CTU ;KOLSPRAWYEF (20) | SEC ID NO: 72 NS iHTL CTU ;

DORADO ANT ON PROGID ND - TA PND PR pall ;DORADO ANT ON PROGID ND - TA PND PR pall ;

APINVPIOISAGEP (Tu) LASER NO. 73 ! NF 1 GEN !APINVPIOISAGEP (Tu) LASER NO. 73! NF 1 GEN!

DIRK BETH 247) Omen NY Ta SA PT :DIRK BETH 247) Omen NY Ta SA PT :

PREY ORTH PY LT} DOES INL SS PE Pole !PREY ORTH PY LT} DOES INL SS PE Pole !

LE SDMANTVY SOM PROGID ND - TR ND PRT OT ;LE SDMANTVY SOM PROGID ND - TR ND PRT OT ;

List RWVYFYY {LW} Pasi NO: 75 | NE ER ELList RWVYFYY {LW} Pasi NO: 75 | NE ER EL

DONELSON ONDIVED (A LSENSVOINN AY TR ES PRT OO :DONELSON ONDIVED (A LSENSVOINN AY TR ES PRT OO :

NOVGOYQPYR (Gi Poli NO: 25 DE PTL, GL ;NOVGOYQPYR (Gi Poli NO: 25 DE PTL, GL ;

POUR EN TENTE PO TE CURTIS FOUR PTT ANS :POUR EN TENTE PO TE CURTIS FOUR PTT ANS :

TT EES PRET NON + 77 1 PR sait £8 ;TT EES PRET NON + 77 1 PR said £8 ;

PNLNESLIDL (18) | SEQ- 1 NO 77 Poel 1 CS, GilPNLNESLIDL (18) | SEQ-1 NO 77 Poel 1 CS, Gil

L'DVYIMAAA SE A FOSSILEN NS - TR | PRT om :L'DVYIMAAA SE A FOSSILEN NS - TR | PRT om:

PONV HEIAENMANRST HIN L SENS NAN - 70 | pa D sal STI ST iPONV HEIAENMANRST HIN L SENS NAN - 70 | pa D sal STI ST i

PQYIKWERWYT (15) | GEO-D NO. 79 SE PB ce HTL, CTLPQYIKWERWYT (15) | GEO-D NO. 79 SE PB ce HTL, CTL

PMOR GmbHPMOR GmbH

PRIC-O00T-P-LU 28.02 2023 Luxemburgische PatentanmeldungPRIC-O00T-P-LU 28.02.2023 Luxembourg patent application

Fer =Fer =

Tahlia 7 [RARIOANLD Dalynantidie OITIDINATION MadioaudnTahlia 7 [RARIOANLD Dalynantidie OITIDINATION Madioaudn

ADS 2, GARD à Gy ENADS 2, GARD à Gy EN

POR | Amino Anis Complex | IGONTTGATON i top NC 1 NS. 1 ANS ACHE Dna À i vol So x i : { i Ë : { i ; i i ; - : ; | Uma ae i Ï ; HUMIDE! i : { à meee} : i He ETRE Fan beeen ITI, Pra im ey an Pana i : VTT ER PEL UPS A PR EIRE PS PES PR AA HES- NO PER à LIT EAST) AMDAGEROYVOTIOI CRI FAS oak ES NS. SE Pod § Ï i i | i. Li i N AY i LS Les ANNIE TER A Ÿ ASS REX ; : i em a RR encens eee een e ec anna anne : | N + 1 : HA SR TEUTTRUTER Pa ;POR | Amino Anise Complex | IGONTTGATON i top NC 1 NS. 1 ANSWERS Dna À i vol So x i : { i Ë : { i ; i i ; - : ; | Uma ae i Ï ; HUMID! i : { à meee} : i He ETRE Fan beeen ITI, Pra im ey an Pana i : VTT ER PEL UPS A PR EIRE PS PES PR AA HES- NO PER à LIT EAST) AMDAGEROYVOTIOI CRI FAS oak ES NS. SE Pod § Ï i i | i. Li i N AY i LS Les ANNIE TER A Ÿ ASS REX ; : i em a RR encens eee een e ec anna anne : | N + 1: HA SR TEUTTRUTER Pa ;

DR € er TM FASERN | CIISNOITS Ng 20 : PanDR€er TM FIBERS | CIISNOITS Ng 20 : Pan

ÈS DWV ORVWRDTKE MD OETT ARS | DES NO: 35 HaÈS DWV ORVWRDTKE MD OETT ARS | DES NO: 35 Ha

L PRY VOR ERIN TINVY | iL PRY VOR ERIN TINVY | i

LL ; RE : i A Fa x Pree preceeeeeeeeeshemeeeeee sens esse sens FF CA WU N in = _ N x AA : San aLL ; RE : i A Fa x Pree preceeeeeeeeeshemeeeeee sens esse sens FF CA WU N in = _ N x AA : San a

La LE PIQUA VR CDSN WRITER Sad RE LS NLU a0 PRGLa LE PIQUA VR CDSN WRITER Sad RE LS NLU a0 PRG

LA LI TANRVOONV APT VIDE DOKN IDE II | DE ND 40 ; + iLA LI TANRVOONV APT VIDE DOKN IDE II | DE ND 40 ; + i

LS POLLY SONY N TS TTL AATONIS RP ON i : : SO i ; mecndemeeeeeceneeee eee n cm neeee eee ec nee eee e nc anen end \ eneseeemssssssseesssssssssesssssssssessssssssses freemen ST egLS POLLY SONY N TS TTL AATONIS RP ON i : : SO i ; mecndemeeeeeceneeee eee n cm neeee eee ec nee eee e nc anen end \ eneseeemssssssseessssssssssssssssssssssssssssss freemen ST eg

PETTERS SE | SESHY AY a : pen a CONRAD | DEC NO! 47 ERC {PETTERS SE | SESHY AY a : pen a CONRAD | DEC NO! 47 ERC {

HE PUTTAR WI ; : : { i Ë i i o x : | X N ae iHE PUTTAR WI ; : : { i Ë i i o x : | X N ae i

A { ; fo fratferanpa\ i i LAIEN } i J i : ; AANA { ; fo fratferanpa\ i i LAYERS } i J i : ; AAN

L A nn 7 = PA X m N AG AN : 2 oN Net 5 }L A nn 7 = PA X m N AG AN : 2 oN Net 5 }

Ho CEA NI RE PRES SN ES ENT A TL ANNE FER 5 ADRDE i EON NEY AD | Peo-SHo CEA NI RE PRES SN ES ENT A TL ANNE FER 5 ADRDE i EON NEY AD | Peo S

Fe | QAARACOQEKDSOOWDT ATK ANNE SAS re re pes DES NUE ay 1 FSD-0 ! 5 | DÂAALAS AR Fe INAS MIS TA TRAY ING T \xA otre i Nae AT : Ÿ i i à ; | A A i i AN - ; - { : + esse sec + SIT TE TON Tm PS ; freee - Er PRERURONAUTS SOIRFe | QAARACOQEKDSOOWDT ATK ANNE SAS re re pes DES NUE ay 1 FSD-0 ! 5 | DÂAALAS AR Fe INAS MIS TA TRAY ING T \xA otre i Nae AT : Ÿ i i à ; | A A i i AN - ; - { : + esse sec + SIT TE TON Tm PS ; freee - He PRERURONAUTS SOIR

LA LREOBDTNOVOYOYDVEA AUTO QE | MAD OS ES NU. 40 DOM DDLA LREOBDTNOVOYOYDVEA AUTO QE | MAD OS ES NU. 40 DOM DD

La DOR a ETT RI SANA MSN ATL AAS Tie 3X | SS 2 NOL 43 > i : € SIM TING GY RP VV VE EN LEA AAS : iLa DOR a ETT RI SANA MSN ATL AAS Tie 3X | SS 2 NOL 43 > i : € SIM TING GY RP VV VE EN LEA AAS : i

PQ PRFWN INGO YM TR V VhorE X | : i em a case eee encens nn anna anne : | N + 1PQ PRFWN INGO YM TR V VhorE X | : i em a case eee encens nn anna anne : | N+1

Brome CREAN TE HOUR 7 PMAYRE NGIGUVTONVIEYE | DÉS NC: 44 PSP ES i [I MATE INV EIN TE i : \ br bE re 5 UE 5 SEBrome CREAN TE HOUR 7 PMAYRE NGIGUVTONVIEYE | DÉS NC: 44 PSP ES i [I MATE INV A TE i : \ br bE re 5 UE 5 SE

DS AFS VDO A AND WÜRSELEN PSEA NO dS Pk ap $ { | \ LM Y VY ANA IRIN LIND OIA LALLY i Salad i Th 15 POV QL WIND A A ; | ; LeeceBi eee eee encens eee e ec encens encens encee : | N + 1 : HA pr TYDS AFS VDO A AND WÜRSELEN PSEA NO dS Pk ap $ { | \ LM Y VY ANA IRIN LIND OIA LALLY i Salad i Th 15 POV QL WIND A A ; | ; LeeceBi eee eee encens eee e ec encens encens encee : | N+1: HA pr TY

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MCR GmbH Luxsmburaische PalentanmeldunaMCR GmbH Luxembourg Registration Office

SA 28.02 2023 Luxemburgische Patentanmeldung . LU ADS ENEDSA 28.02 2023 Luxembourg patent application . LU ADS ENED

DRACLANOT DENDRACLANOT DEN

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The antigen peptide formulations in accordance with the present invention (Groups 2 and 3 4) After five weeks the immune response was determined, T cell CD4 and CDS activity wasThe antigen peptide formulations in accordance with the present invention (Groups 2 and 3 4) After five weeks the immune response was determined, T cell CD4 and CDS activity was

The immunization with a combination preparation in accordance with the present invention, particularly with Pap X and Pep © induced strong and multifunctional Spool? and peptide mix specific CDS T cell responses In comparison with the no vac, group 1 and even a greater mi * aan aT ation with Mie JT EN $ 20 SX meet s etransger ANR CT Aall gyclic-adenosing monophosphate (0-d-ANMFS adjuvant (Pep ©) induced à stronger CDS T cellThe immunization with a combination preparation in accordance with the present invention, particularly with Pap X and Pep © induced strong and multifunctional Spool? and peptide mix specific CDS T cell responses In comparison with the no vac, group 1 and even a greater mi * aan aT ation with Mie JT EN $ 20 SX meet s etransger ANR CT Aall gyclic-adenosing monophosphate (0-d-ANMFS adjuvant (Pep ©) induced à stronger CDS T cell

The immunization with a combination preparation HT accordance with the present invention, induced by ihe combination preparation, in particular comprising antigen pantide from SEC IDThe immunization with a combination preparation HT according to the present invention, induced by its combination preparation, in particular comprising antigen pantide from SEC ID

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Therefore, À is possible to quantify the parameters which are particularly influential in the input-outpui between different entries, The correlation is given in steps between -1 and 1.Therefore, À is possible to quantify the parameters which are particularly influential in the input-outpui between different entries, The correlation is given in steps between -1 and 1.

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MC-O007 LA,MC-O007 LA,

PMC-0G07-1 aoa 3 vi fied RAT AAR 2 $y mia RATLANTRNPMC-0G07-1 aoa 3 vi fied RAT AAR 2 $y mia RATLANTRN

Has of the peptides MT-ATIS. i rological properties oF Ing DODtOGS WY : mien = pertes of the pes . = rue Vs as aye SEAN NG INI HOMO ION proper ‘able 58.3: Hochemicalimmunolo i | ;Has one of the peptides MT-ATIS. i rological properties oF Ing DODtOGS WY: mien = pertes of the pes. = rue Vs as aye SEAN NG INI HOMO ION proper ‘able 58.3: Hochemicalimmunolo i | ;

Table ES EST TEEN HIT U a “3. DOT!Table ES EST TEEN HIT U a “3. DOT!

ERDE DO BIG rissaERDE DO BIG rissa

Tn T PRETn T PRE

TTT | Antigen i i Ï | ANSE May X aan U | } EsTTT | Antigen i i Ï | ANSE May X aan U | } It

TT Adler | Ë { Po aeTT Adler | Ë { Po ae

TTT i het i x } N fit arTTT i het i x } N fit ar

Nol | Al METER | N + He p$ } an o | y ax i anNol | Al METERS | N + He p$ } an o | y ax i on

RE i i 1 #5 ES | Dead i start {RN ; } | pra 1 ENTER i 1 ; ! | NAS T 1 SS | | Pro 1 ND ï Ç Tue : | SIGGSSL i ÏRE i i 1 #5 ES | Dead i start {RN ; } | pra 1 ENTER i 1 ; ! | NAS T 1 SS | | Per 1 ND ï Ç Tue : | SIGGSSL i Ï

Po 1 THA | EEK PL, i : { i { ; por Po Peat | Ë | Pe i | Posey | i a i : ; ef mm v T KU 0 "ri : ANZ HE ve 077Po 1 THA | EEK PL, i : { i { ; by Po Peat | Ë | Pe i | Posey | i a i : ; ef mm v T KU 0 "ri : ANZ HE ve 077

TTR ATT, 0 PaO | A235 107:TTR ATT, 0 PaO | A235 107:

CE RE OC { = iv te :CE RE OC { = iv te :

An | Ei 100 i US BRAn | Ei 100 i US BR

UAE : {++ OANA i i | enon]UAE : {++ OANA i i | enon]

A to po i | ee asA to po i | ee as

TTT sara AS FanTTT sara AS Fan

TA HS + VANS i HN | ' ; — ; i aN x HS i TSUNTA HS + VANS i HN | ' ; — ; i aN x HS i TSUN

TTY i HN aa i tin? iTTY i HN aa i tin? i

Tas tn | i NA Pan i TL | ReTas tn | i NA Pan i TL | Re

MET | i 0 00 i 142 I 1 : {+ OANA i i HE RAAT .MET | i 0 00 i 142 I 1 : {+ OANA i i HE RAAT .

M3 } + | ) i X : Le Heu bo | ER DO Pas F048 1037 ï M X kn X FoI HE A X m XM3 } + | ) i X : Le Heu bo | ER DO Pas F048 1037 ï M X kn X FoI HE A X m X

Pa fi Pn FOO PTE | A ie * i” Po i i fe - NTPa fi Pn FOO PTE | A ie * i” Po i i fe - NT

N 2 | ; | : i an ————- + - Ti Fi ; z ' - | CUP i > | DA LD AR 10,15 ; TITUS | 827 | BA | 045 : J Pan Dan Ey | 841N2 | ; | : i an ————- + - Ti Fi ; z ' - | CUP i > | DA LD AR 10,15 ; TITUS | 827 | BA | 045 : J Pan Dan Ey | 841

MA, EU Po i : { Lun À jee ” | | : i TEE LA En { A A >MA, EU Po i : { Lun À jee ” | | : i TEE LA En { A A >

Las | EH Vo : { x 88 O07Las | EH Vo : { x 88 O07

Fa Pian TOR 1086Fa Pian TOR 1086

IN { | POG Pou i | TTIN { | POG Pou i | TT

AS i PTT x VER i i | CT | oeAS i PTT x VER i i | CT | oe

VARA + i | } a : = PERVARA + i | } a : = PER

Le En | : | Se t oA LA A na : { WR ; 5 | AQA LD AT 1963Le En | : | Se t oA LA A na : { WR ; 5 | AQA LD AT 1963

ETT Lan Pavan | die 1042ETT Lan Pavan | the 1042

TTT ban On 19705 | 954TTT ban On 19705 | 954

FT i : 170 100 1 570 | | | co a | : VV | VV i | A ATFT i : 170 100 1 570 | | | co a | : VV | VV i | AAT

LAE por Poi | i AT oo en - | ; Denen en ene nee nennen TE LA neLAE por Poi | i AT oo en - | ; Den en ene nee call TE LA ne

Le | : | TE t La LA 4 | 105Le | : | TE t La LA 4 | 105

Le | : fro Paar Loans 1454 10Le | : fro Paar Loans 1454 10

EE 100 : 4023 | 1035EE 100 : 4023 | 1035

N | | Posy PAL i | idN | | Posy PAL i | id

LA | ; snes CAR Uo an - ETT RR PRG TR PER OAD : corroooooTae Lan bag | 78 CLA | ; snes CAR Uo an - ETT RR PRG TR PER OAD: corroooooTae Lan bag | 78C

VS UT | 1 V0 VD ins RCIVS UT | 1 V0 VD into RCI

AA {oo }o+ PAN LL SE RN RitAA {oo }o+ PAN LL SE RN Rit

Ma Er | ; Ë | : LL en ï 5 5 5 'Ma Er | ; Ë | : LL ï 5 5 5 '

Lacs En ; | TTT I Vom Lane 1032 - | RET Poa Lan7 083 LO.Lacs En ; | TTT I From Lane 1032 - | RET Poa Lan7 083 LO.

CE A AN 1593 397CE A AN 1593 397

MET | 0088 100 DAS LM i RaMET | 0088 100 DAS LM i Ra

PA RER i TEI A i 325 rm EN Poo PARR 1 172 pti | VO 55 Lot ASEPA RER i TEI A i 325 rm EN Poo PARR 1 172 pti | VO 55 Lot ASE

PRAT 1 + } ++ POA | i Le liPRAT 1 + } ++ POA | i Le li

A | ; Hogan { x Dom an 1021 - | Tee TTT 3 EN Pan 3a ; TUT A Lan 14002 | 4070 iqA | ; Hogan { x Dom an 1021 - | Tee TTT 3 EN Pan 3a ; TUT A Lan 14002 | 4070 iq

PULSE 100 i | ed RoPULSE 100 i | ed Ro

TAIZ 1 + por i VOS | FE FA ie Nl ed ; BE pres aps Leave Lora 1047 pr ean PAR | 203 ereTAIZ 1 + for i VOS | FE FA ie Nl ed ; BE pres aps Leave Lora 1047 pr ean PAR | 203 ere

COTE Pon | 153 ART FC | jCOTE Pon | 153 ART FC | j

Te ; + POA | i gu.Te ; + POA | i gu.

PRIS + | ++ i | PT dE Tali _ _ | | LTT | eneser : nn AG aPRIS + | ++ i | PT dE Tali _ _ | | LTT | eneser: nn AG a

CS PART EE 1487 } SA. Hal RHEE ÏCS PART EE 1487 } SA. Hal RHEE Ï

TTT TTT 140 Pan : 487 | 205TTT TTT 140 Pan : 487 | 205

ET Vas LRQ QU OR LT 3 ; $ + x VIA i iET Vas LRQ QU OR LT 3 ; $ + x VIA i i

CARTE + | +4 i PE Zn _ i NT La NA La sn _ - | 7 ee | 4e : 4 pl 4 | 2 ; 3 2 ; CUITE TTT 1 450 | i 4 a | 1A ; Ti i | an x HES } ie ; ; TT i i i aw 1 US {CARTE + | +4 i PE Zn _ i NT La NA La sn _ - | 7ee | 4e : 4 pl 4 | 2 ; 3 2 ; CUITE TTT 1 450 | i 4 a | 1A ; Ti i | an x HES } ie ; ; TT i i i aw 1 US {

TRAE TTT i LAN | an | 3 1936 | | ++ OR {20 i | LTTRAE TTT i LAN | to | 3 1936 | | ++ OR {20 i | LT

PMS | iQ TT _PMS | iQ TT _

CT | ; ri PTT Fr ; Fe | son ! Lo P18CT | ; ri PTT Fr ; Fe | son ! Lo P18

II Pon fa R Du | | N a | No DO | 236 i | LI 14 oF VON fi FA | ; | LTII Pon fa R Du | | N a | No DO | 236 i | LI 14 oF OF fi FA | ; | LT

AMG | ++ | No | 27007 27 - eee | HF i i Pad pr : 4 à ! 2 A > oa Ï | mnAMG | ++ | No | 27007 27 - eee | HF i i Pad pr: 4 à! 2 A > oa Ï | mn

PRES 19 Lu Ti su -PRES 19 Lu Ti su -

ETES | No } 470 10 | pesETES | No } 470 10 | pes

PRAISE ++ | No ; | TTPRAISE ++ | No ; | TT

PIS OT | i ER i idPIS OT | i ER i id

VEVE

3 ische Palantanmalduns3 ische Palantanmalduns

Luxemburgische Paientanme ungLuxembourg Patient Insurance Fund

GR SON 28.92 2093 LUXSE UGR SON 28.92 2093 LUXSE U

SO A000 AV EDSO A000 AV ED

DRACONISDRACONIS

PRC-O007-PLUPRC-O007-PLU

Claims

an s= Ve SV m2 Os NS 4 À are ns ale in avant TAN far fo U - di i ; al { :, : ç 1 À nharmarauticos! composition far use as a meadicamant in nartiquiar for usa in the oA PhHarMactOuticai COMDOSMION TOF Use ag à MEdiCament, IN PartiCLar or USS in ng PA FO vas in fi à x ; cm ns Thvaranantie sin far ra Büren fraatmant DEU nn a Ï & SNA AT Areas af eyes ie stars &, wield © Ra ei X : {Tam di, : > subiert or aroun af Suiecis suffarina from or at risk of suffarina rom a viral infectious OF al HSK OF SUTTSTIS rom a virg! imacious =: ut MHIQBATS PAUVVANPTISIMEA CSSASS, compnsmng : data 1 RCE : a nhermansinrinpaie affaniive ami eanaiod inn = at à 3 2; i sit a nharmacoiogically effective amount consisting of at least one antigen noïlvhentide FU EC ohne snigen DOIVDSDTQGE RAP NA Sans at lnnact sana LIT ALS cod nae AM or oc 2 . ; SSQUENCE SOMNNama at isast ong HLAA and/or HAS antigen wanting wharam tha SSQUENCE COMPNSING al ISA ONS MULA-A andior MLA anugen DODICE, whereby one AN MLA antisen nantide carresnanas to at least ane arnino acid senuance of at least 10 MLA antise YAY an asnanas i =o an € 2 BA acid Sontence of at ipast nna INGEN DODIGS COMSSPONSS 10 at 1038 OMS SITHNO 8010 SOQUENCS OT al eas ong mie SSH aA Fe nn ie one N 4 & 43 = = CITES TTONSCTINTQITTE sreafarshihv SHESNTINS a nai of he ViriiS Suirinsse Dr den YS SE VITUS TanSCMione, prefaradly entQQing à part OT ING virus SUFace protsome, more nrafarainis sarrsenanaline A à nat of à viral antoine PrSTGTADIY COITSSPONQNIS 10 à Ban OT à viral EDHIODS, Shara otarieast in Shad CHATACISTISSd IN Tai +R de Shans a nd N y > Dr A =: si, &x. Sha mt ima everest ite sans a AAN tive Selena . SF and ad 1 x {hs antioean nokmaentide sesusnce comnrises the fallawirnn seaffald amino acid senuence” NE antigen DONDSDIKS SSQUETICE COMPTISGS INS TONCWING Canad SITHNO adi sequence! fal n ann manta ix N AAN ae nt : tint 3 : ; : fay a long nentide ie a Commound construecti or noalvnantide wharain the amino acid (8) à ONG poptde, LE, à COMDOUNS, CONSIUCI, OF DOIVREDURE, Wwharamn Ing amma add gantiannce af whieh eamnrisec ana MME ALA antinan mentir Lit A N ® Kid sanuanes Sf which comprises ans HAGA antinan gentindes or HE ACR antinen nentide as SSQUENSS OT WINCH COMBINES ONG TILAA aiden DENIS or MLA-D anugsn pele as en se à . : _— . : a ANafinas Harain wkarain ha aminr gi = Lu nr : 345 3 SU defined herin wherein the amino agig Ssousnte Comnrises in addition In the HLAGA SAL HS > à 2 à 2 - = += RS = ét DENON Fra Te Y ~~ Jd ARSTER DIR, VWESGH ASIEN nig SEEN ald sequence COMPnsas, RT AQQIION 10 INS MLA-A antisan nantirle ar Mi ALD antisan nanticta + Se À LA IA : DA ; AMIE DaNTIaE OF MACE SITE VOTE gan TO TT A oa asie anne ar ANUGan SSEDUUS OF MLA antigen DSDUOS, UD 10 1 10 QU aiming alias, andidy fon ttt ts € A a cimillarihs nants ia SE PSN NN VEN SY SANS UE est RU ai i 3 +5 £ £ HY a similarity peptide Le. 3 compounds. construct, or aal/nentide wherein the amino ac 4 (0) à SIMHSTRY DEDUGS, LE, à COMSOUNG, CONSIUCL OF DPOYDENUCE, WHarain ing aiming ACIC ROME IANO AT wel ie se Seinen in Fam at ns FIN ware Tey ét RAI A A 3 Ki sequence of which is as defined in fem (at or (D) wherein the HLA-A antigen peptide SSQUENSS OF WHICH IS 88 GETS AT jam (a) OF (0), Whargin ing MiA-A anugan papas ar Mi ALR anfinen nandide ac dofinad Karain having Loge #$ 1 GE, initié ar $ And © gan nant à as deotmar (Tant Ravina ass than 10086 SGanueance an OF MLAS aMigan DSDUGS AS Qannad Narain Navigating E33 Man TUN SOQUENCE iHamny SE LA tt. ds 88 : Lis N Ar cimilisrie fa tha noîlve WEA antinen narntine si § ris so QE 2 9 Simnariv to the native HLA antiaan DENIS. such as having at almost 88% PAYS de QF SITES 10 INe Native PILA antigen peplida, SUCH as naviig at Past Sp, more nraferahh: of iaaet O0 <anianse idantihe andar DrGTSrADiy at IGSST VL 0, SSQUETCS IGENTy, ANOVOf FAN 4 Sn het manélsie € ; var ; : : iA ins oY a quhefitition nentide ia A anna nun en same aahamanting wharain tha amine {CG} à SUDSIRUTION DODTIGS, LE., a COMPOUNG, CONSTLCT, OT DONDSDUGS, WNSTSH INS amine anit carmanes AT wich le se Aafınarn in Ham fa Fa ; 5 Ly wit A : acid sequence of which is as defined in tem (A) or {M wherein the Hi ALA antinan SLR PAGE UT WIR IS a0 QOIHIQU M HORS (ai Or AD, WHATS INE HLA-A anugsn ; > nantidea ar MI AR antisan nantilse ac Safin harai $ (ie 3 5 entide or 1 Auf Amin nanftitde ne dafinadd harain Haut an srminn asic sennanne PEDTGE OF MLA-D anugen DSDS 8s COTNOU NOrSIN naving an amd acti sequence J Cs et . . an PA N AF SNS arena whether Anh ann an te SEE fendi ï ; camprising or consisting aasentiaiiv of anv ane amine acid aubstiintion relative to the = COMPHSIG OF CONSISNNG SSSSNTiY OT Only ang amino atid SUDSTHILEON lOIJUVS IC me Amina acid canance af the native HI À antis a die £ In acid Sansa he native HEA antinan nantidar andiny QING ACA SSQUETICSE OF ING NAVE MLA antigen DEDCE, angry SAI Ak PMCR GmbH RAC AAT.

Di 1 SR AD ana PMC-OCOT-PLU TROD 2099 Laugariiretisehe Patantanimtmetbste LVL © EA NEN Luxemburgische Patantanmaidung a DAS LU103079 {hh atandem peptide, wherein the amino acid sequence of which is as defined in Hem (an, comprising or consisting of at least = , identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in items {a to (0); and/or the amino acid sequence of which is as defined in tem (a), comprising or consisting of at east 2 identical or different HLA-A and/or HLA-S antigen peptide sequences, both their amino acid sequence, and/or {à a tandem and/or ovedapping tandem peptide, Le a compound, construct, or alternatively four different viral infectious diseases,

2. The pharmaceutical composition accordme to claim 1, wherein the antigen polypeptide corresponding to MHC class | Complexes is selected to match a sequence of the viral apitops of all two different viral infectious diseases, preferably at least three viral

3. The pharmaceutical composition according to claim 1 or 2, where at least one antigen polypaptide of the pharmaceutical composition is a tandem and/or overiapping polypeptide consisting of at past where preferably at iaast three, more nrefarabiy at isast four most LAMISIL IY Vi QL IER LAY, TEIN ANY Sl OGO UGE, NUE SSD YO Tmo IV, Hey preferably at least five amino acid sequences from the epitopes of at least two, preferably of at least! three, alternatively four different vival infectious dissases, two, more preferably at least three, particularly preferably at least four, most preferably at least in accordance with the current invention and matching the epiiope of at least one viral nfactinune Mapace HERA RLRLE RRR R EIN Tate Reh FMCR GmbH PRIC-GCO7-P-LU February 28, 2023 Luxembourg Palentan declaration ns en TE = + an TN Cn En Where ; aa: Pan 5 248 sss Ç cer € & Tha mR arm Sea nasty! SAMISNEiAn according fm ame aime 1 ta A wharain the samanchian ia

>. EMS PRarmMaceUliCa COMPSON alloramyg 10 any CIRENM 1 10 4, WROTE ing COMPOSITION is nrefarabhs used in the nranhviavis andior fraatmant of a virus infastions disasas SERIEN KRAUSE WOT I WI PPT AONTPI VIRUAISS QFE WOON BT 8 VITUS HHTLULLS MISTER. ga ve pe des Ra ANR em NOR à od dem enh SN ENT AS pue qu LA 0 I LN SS sante Sa im À = = EEE ETS CE ee uen eu ve et LE 8 Tha sharmansaıdheal samnansallan according to a anv claim 1 1a 5 wharain tha cornmopnsitisrt is To ENE DIENTEN EN SONMPOSHION SCCOTANS (any CON 1 10 5, WTISTENT Ig CONMIDOSITIOIT IS = rs a en heb ana aan A rene de Tessin den ee an pd SP PSS MY NY FIAT BEY NÉS ven Ih ean yo = arafarabbe nigart is tha arnabhulavie sansa fraatmant of a parnnaulrie infactinne Nisasse D'ETSIADIy used I ne propnyiaxis STOP roams OT 8 Coronavirus INTGCHOUS Qisease, Van Cee an van baise CENA EIEN SAN FY aa an end] oa 33am on an - mines Greater bu ÿ SARA nfacstiniig MASS PEN AMSTETTEN SAMIR AL AWO EERAAAEEN Hot qat, 7 Tha aharmansırlrfal samınanalllan acearding fa cian & wharain tha Li ALLA ancdtfnr BM AR i. ENTRE AMIS IRANI WAIT ONIN LLIN AUS Lair RF, VEE ROR ADS TILES anna N aA À > > antigen nentide is an anna acid saguancs selected from the ground consisting of SEQ ID SHOT VONULS ID al @itinl ail SEL USTILE SEIR0I0Q won Hg LI OUS GUTISISNEIL OF Ort 1L2 AN Ries À ax En x : I 5708 ; HA Wed 3d, OY — 15. 2 A Eh Tm PRE an SE eh Re an Re uo A En ae 1 "ne pe onl din snd ew ens 2 NN CT Cab ems me hen A BNR en S Tha aharmarssautinal sarmınasitian of any ona of tha claims 8 and 7 uwhersin the antinen

8. NER HOUSE OF GOD ASEOSANENOMAEAESOMAEOREEESONMAHSSEEEEND NF, VNTIST CES LVI QR INR cen I a NÉ ON Be SEY SN IVE Een Ani N = Si Conon mat SAN Fran RE Ar TAN FON IN RANG Mahn ET ITE IS ar armmirna SAN SANTA SNS salardtan Fearn Tha OSSI coanoisting oF OD! 7 Ni > DOYREPUGS IS 80 SING aCid SEQUENTS SSIGCIES Wom INS group CONSISUNG OT old iL NS 38 58 AIG QQ An 12 O The nharmacaubicat camnonaition of any ans of the claims Sta 8 further comorising at least a PAINE PAT DIGI RAG SAISON kan Wy MIS ATT REAR RSA Ee Laks s, TREN LISE AAS (son Sab IS CAR SNS SR ST RRM IS CN CN NE SATEEN NA AA Cy SEAN av eva IP A A edt A EN si N ANS armina Ao SANIANPS PAMIATISIANA ar canaiating af an SN AL A ar FOREST antinan nantida ONE aiming ail SSQUSNCE COMO ER Of LCUNSISUNIG OF SUN FIASCO) PILAR aiiigen DOPSOES, whether van x À ae vdi à ç bite = © x te + 14 SITHNO aid SOQUENls HT INS . 3 ; ss EN A TE N pa 3 i Et Soh 3 PE Arran oar euch ae amis 41 ann OF damain nuslancanelst aratalnı anvalane nratoin 3 aviri ti a8 © = 3 ; 3 wiancans nprote ANANAS n pif COTONGVITUS, SUCH as SPIRE SI ANS DE QE, UGIQOLAUSIQ BIN! hve RIE Pme saws Fong ND A ma te AN is ANN SN à Bad he ST SENS NY EV EN IK 1380 DOIVDIOHSNT. AR EL 3 IEP tes x voi fan ag NS N ; 3 AN Tha snharmacsadieal samaneitisnmg oF amu ans AT tha olaime À 45 D wherain tha ENS FISHER CUTTINOSIEIGN D NY ong OF thé cames © 10 9 whigram INS Parr a eo Wea] srr aaa diam SAMNNISHDE af Ilnneo! faux anfinan mobail aharnin the SRHArmacantisal COmMnDOSHISN camnrizes at least two antigen novnentides wherein the SPHISRT TECH REIHE! CAT TI COREIGI TE SCOMprSES ESS NO KANNE PUY LITLE, Winging UE at A x at = 01 Clad Sui oy à à i ; sis x WE AA ame ia ME ALD antisen mania af tha at lancé hes syn naluneantides er As Sa SLR and ary vee sa Fhe © 23 ; sn py an NAN SNA et = aer x FHLA-A SMNÜOT MLAS SMMUGEN DSDUGSS OT ING ET Gas AWO angen DONDSDUGSS COMSSDONG “a Fen ey 4 mien ond ior end ed iE Tene pd ob AE EE en SAT Te Hans Dan Sereno Fag He of e YA SATII OTIS AT N asta Oat PRS SANTSYNMATEIS NINE SAISON TRY tha angle S01 ES 0 À COMDMATION OF Ciaran Pains OT Ing COMCNAVIEUS OPTIONS SOIGCISS am Ng SDIKE SI 3 an gan bans DS ad ann es aa “ 5 2 PN net ATI a Nue oN er pue bas gen aa “née Te CPN aN Fan an STA RTATT Ra en pn pu ae on am 89 sama Wiis iansanaist Crater ameainng SNS AA MIRE TS PARTS ANT MIT QOMAN, DS COMENT, NUCISOCCAOSIE DrOISIT, SNVEIONS prota and/or URE 180 palyprotem, Ar re AY A ENS ens $i aad PES EE RES wa $A ae a CA +5, on den bang A yo AN 5 y les enn ye ens ype A fen po 14 Thin nharmacnautina! earmanaachian of any ane of the sisime 1 4a 40 whoerain dha Ti ES UOTE CLULE WAALS QI any VIS OF THE Clans 3 10 1 WHEN US : Coy oe . : wn rN : x Ly Fo cam Don rad 2 nharmanaindtisaiks arsantahle servant parrer chant andfar svoiniant SU PHAarMactSLTtiCany ACCOPIADIS adjuvant, camer, OHUETT and/or EXCIDIENT, Ras Saad i FMOR GmbH DRA SWL DD à IE T2 AS DD Eté rent vrrciecesbres Denke ba rien Et rte PMC-GCO7- P-LU 28.02 2023 Luxemburaische Patentarmeldurie an Le NS A Lisa Fa Aa Sans Fife sraopartiinn sisime far tha nea iti ë ording to any ons of ths DTOCSGINQ CIAIMS TOI ing uss 12 TI harmaceutioal composition [ACCTING 10 any ong OT INS RATES NII Lia té. 1118 PRarmaceliica COMDOSITON a \ X ; 353 : anne auhourtaneaniiaiks + ; CSN aan si tian is anne t subheotas OS t forth i Siam 1, wherein the ghamacsutical SOMDOSHON IS BODEN SUDCUTSTIQOUE Ys Se OT HY GS N ANE BREAKS TEST EEE Ge SS SET TOMM Siam PO VINS ALTES MIE $ int uses uiari nr intradarmaiiv ran to you rade ally. nramuscuiany WHI GUGITTIONY S 3 3 is auhiarnt ie a huran si + dam 19 wharain ead quhipnt is a han an as ah a Ta Se IE » ë = > se X shel Ya A ON vA PIN Y Sm Ty harmacautioal coamnoasition ACCANGING 10 CISM 12, Wharain saa SUSE IS © THE 13 IE PRATMACLUUCE! COMPOSITION acgoram dal el, ; 3 13. ENE Pnarmacauica: LAST Gi 3 à Bu au SA at © ; 19 Far the ae dat feet in olan . 24e Assmann TAN slopes 7 ten US fey the use set farth in claim fa FH Abs asa étend SOITIDOSITON SOON KA HN a I IE pnarmasauitat CO SOMITE QLD I LS T4, TNE PharMacteutican AHA EEE i N ce ' Cag sem i time fn RARES ï H 3 ASE ene rN ey IY TEN ty RARE u. YPO 1, WiCICH ; = 2 ; simadt hu manana nf an man nentidae adetarminmaec bu means of an i | complexes are Immunogenic antigen peptides, GSISTIITNSS NY Sans Qi € Diass | COMPDISXSS ars mmunogemc ant STE AU Ciass | GUN NICASS Gt y © i fF \Aflactarn iad 3 ; 5 $ © ea ia) Bir aan ANT V7 ESSEN Hin foil assay, in particular {Dit not HITHER 10: Oy Msans orf vvesiorn [I 40 mmunoaaanicity assay wa SEN MILAN ARAN DEAN 3 > ka 5 = HTMLTOQETHCHY assay, Hi MAIL X 1 > “res as Aniques EiISDOT OS ARM i y (FC) ELISA techniques ELISPOT end, SAR, Ï i i Scent immunoassay (ECL) ELISA ACHAT HBAS, CSP Kg! \ ; Electrochemical immunoassay (ECL). ELISA tact i DISctochentiunminescent HRMmunoassay | 24 wi x T N 4 € dd FAT has tien aot : ' AUS ana of slams 1 tn 1d far tha or a set is, Th Ï macsuticai composition according to 19 any ona of Clans 1 to 14 Tor ine Use SS Ag Pa rnhsrmanmitioa TDOSHIQN ACCOIGING 10 any On Po, HE Praia etlinta KOT DIN N ii LEA Ly Hide andine LIE ALR $1 ¢ HALA antinen nantile andior FL AR hoi ial |, further comprising at least ong LAA antigen DODUd® angy/gr MLAs forth in claim 1, furthe COMPING ol TOR DRE PILA-: SAIN MT 39 TORN NT CIM 1, TUTANGS LAST II EI N ï co on i $ AA places | pamniovae

- . aera te ASRS of £ complexes Han paplidas corresponding to MHC class | SUITNIQASS. antigen DODIGES COMSSDOTGHIQ 10 mm. CIASS | $ SET DSDS GÜTTESDOTUNNG 5 an & : “ à AR far The usa ne cet ce oe § us ona Af claims 1 fn TK $a the use as set 18 Th + nacautical composition according to ANY ONS OT GIFS 1 10 TD TOF INS USS ES SS FE hé Dpharmacevtic at SATII SOLS CHE) AL Qnty Lhd

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17. 18 PPT ICRT SI TET GC SENDER VA ENST U 3 ¢ g Wine heist esd i : i SE, now ama int of aaph inmoividiial Ï i i the harmacologically effective AMOUNT OT SEN INOIVIQUET 3 cad in claim 1 wherain the pharma DIOGICAHV ENQCOVS arian of rechec HY OCR i à if is vs A AS ES TECHSS IY CAM 1, wharain ing $ U 5 : TN > men niert an IR ss y absolute concentration (Le. administration in ti THON IS HT an alse CONCSTHISUCM (LE, aaministraton 2 prés es 14 dha SEMINARIANS WY an QR SCHUNG CONCONT QUO (Le. ANtigEN DOIVDSOIdE IN Ihe COMDOSITION 19 IN an absolute € amnigsn gaiypapiiaes WANE LAHTIUUONRE SRE ESS ¥ El = x & 3 Yes AN OH A TA a 3 Sar tha rea x u LLIB a € À ses: ivinietsran se i i i NDOSTEUN Is acdministaran as x a ÈS FENN PONS MF i sv rad 38 forth i the claim, wherein the pharmaceutical COMbOSRTION IS SCYHMSIETON as 3 set forth in the olay IIE HE KERNEL LEGEN GUN Sel TON IN TS Cam, wheroii ing À à 2 Si TN PMOR Cini i em ber iche Patentanmeldun PMC-C007-P- 28.02 2023 LUXEMOUTEISCHS Faenianimaiqung PLU 23.02 2023 Luis ï PRIC-COO7-P-LU LOAN Æ PMC-GO07-P-LU

On Ns LU103079 prophylaxis or a first-line therapy to the subjects or group of subjects having at least one identical MLA allele,

therapeutic or prophylactic treatment of (a) viral infectious disease(s) or for a HLA-À andior HLA-B antigen peptide, wherein the HLA antigen peptide corresponds, preferably is identical to at least one amino acid sequence of at least one virus corresponding to à part of a viral epitope,

wherein the antigen polypeptide sequence comprises the following scaffold amine acid sequence:

{a} a long peptide, Le, à compound, construct, or polypeptide, wherein the amino acid defined in; the amine acid sequence further comprises up to 110 30 amino acids: and/or

{b} a simiar peptide, Le, a compound, construct, or polypeptide, wherein the amine acid

203 O1 AR antinan nantidds as dafined harain having ass than TARA sanuana anti LU UF FELAAFIRS SIEG HS AMONG dS GO NETS Naving 00% ain KINO SUQUOTIGO BARS TAI arafarabiv at laast 80% caauanes indantitur ancdor POISTANIY AU ERS VU 70, SOGQUONCE IQOMAY, an i

{£} a substitution peptide, Le, à compound, construct, or polypeptide, wherein the amine acid sequence of which is as defined in Hem {a} or (D), wherein the HLA-A antigen comprising or consisting essentially of only ong amine acid substitution relative to the amino acid sequence of the native MLA antigen peptide, and/or

{dd atandem peptide, wherein the amine acid sequence of which is as defined In fem £a),

peptide sequences, both as defined in tems (a to {go}; and/or FMOR GmbH PMO-OG07-P-LU 23.02 2023 Luxemburgische Palentanmaldung en Vi Ss Sa Sa PNENEAN SN ds N bite x er EN 5x ou N a ond A ae eb oat Eo rhe an yuan dg Fa) sa AALATIATYTNTUN am las NANTES Ta ANNE smart ent arm mn humanen weharsin {8) an OVSMNADDITEG Tandem pepide, LE 8 compound, CONSUUCL OF DONDEDIQE, WÄSTSH An RN on ene A vite oe a Ananda ten emer ol em Eigen me ab A a fay SN BRN EN YY a ~ - pend ae ay amd the amino acid ssauence of whinh is as defined in Tam fa comansing or consiatina of iE SIT SCHE SSQUENGE OT WHICH IS SS QOHNGG in Jom (27, COMPNsing OP Consisting OT oué à < oF Ii EE ben an NIE ~ EE] A A ae LAY A EN A IT = . “ix a.

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AN TON PI TA Tha Matha of ane afthe claims Sata TA whars tha ounithatie nalpnantimes srastast in ofan SUL ERE MONO OF any OF INS CIRIMS 2D 10 JU, WAÄSTES Ne SYITITIQUE DONDSDUGSS CTOSISG ih SISD MS sure ue one dem een whether oy gerd {ay AN Cn on NÉ han ee - bend ian EN Fo) © net fae = eu SE EN NES NE he a on a {ely are nraferahlv antigen nolvnentiries consisting of tandam and/ar avarianning antinan (QI AS POISTODIV SIEGE DOIVPOPIGES CONBISHNG OF 1ahQON anal OVETISIDEINS antigen + A Ne en ASS sis ane RAS OH pu MS Ta SN ay on RT om ii mad TT i Hantidat coarreenanding fa ARO | andine AAD NH sAamnlavas and matehing Doral and Troll LEQUGES COTTESPONCHIG 10 NTHIL | ana/or Mme À COMDIGXES and mardning D-COH ana 1-CGI au a NON entanens SHVRSS. = 3 YA Than Rats st mt pu Ain pu} en he + Da ba us + € OF bre sent, A vb aa + Sn 1 ha Math nf amg af tha pinimie 28 dan A wars at sac hee aywratarahiy at asst Thras Si 1106 MOTOS OF any OT NE CIAIMS D 10 27, Wars at DAS Wa, Drareradly av igast three, mors nratarabiby at least four asnecially nrefsraiiiv at feast six most nrefarabiy un io haha FINIS PATI QTY QUE IG CIO SALAT, SONGS ICTy SHERRY AROMA DEAD, SA TAO AHRENS ANS VV TWIG antinan aahynantidag ara ardanaad far ea an a oambhiinatinn nranaratian for tha ASS TION Antigen SON DSDUGSS arg Mangas TOT USS NT 5 Drofaralion TOP ing propmyiaxis ansine frastmant AS aro n of euklente with riele of coarntrasting at lanet ane viral infacstin ge and0r Samet OF à group OT SUDJIECIS WEN ASK OF COMTACIMIG AL GAS) ong viral intgcuigus AN H on ii diseage Hs VISANT. DES CT en RA add AT Ba Ames CN A Ca EA en een Bla ae em end A es yen yen b EEE: en VON NUS TEN RE KR EEE EN a eran LE a 22 The Method oof the claim: 31 whare the antinan nolvpantides of tha combination nranaratian Sel PUR AAEETROW OF WHE SAIT OF, WHE Ihe anion MOIS POPOUIOS GT ne CLINRIN&RNGH MG Pen GT arafaraiibe soar mera fhan OR 04 of dha Mi À alladas of Sea wncieeheise Baviam set lation DretSraniy COVET More an VD Yo OF INS MLA S161658 OF ING WONMVIGs NUNTEN DODUISIIOM. 45 33 Tha Mathias AT anu of tha sisime 241 andine AV uchere tha quhiante ara human

32. ENE MOTOS OT any OT Ne Cas 51 anil 22 WNSTS INS SUDISCIS arg numan. SA vu 8 dd tone = a : a ne 45 we : ; TA Tivos Antist oF amy of Tha piasimme DANS shares TRS van ims sine AH Sa are SE TRE ENG OF SV OT Ing GARD © Em, WHEE MO FOSUNNIG SNS SEK SOQUENLSS ale pente proms Ba à aeons Bon ate mod Been EAN ITN A EN “ae ge sn nn nrafaraihiy calamities) fran QR HH SNM a SRE LAR MD Ln D'OTSTADIV SSIGCISd rom SQ 10 NOS, 88 — DE, SU — VU, A method for oreanaring a pharmaceutical comnosition according to any one of claims Tia As AAS PA NN RTS TS M DD PORT SRG GA MEAN ESS ELENA NS WITH CV CIEL LU a AES A Lamia AS SD SP VAS EN EE ES hah te Ben an en EE Mn ' cd mn pny en TR essen tha fabio stone it, COMensing LE TOROWING S80. fa\ datarmininn of Lanet sans nraeferahie oof lancet fus mare nrefarainie whether asst Three {= ata = ne = afaran = AO fag sr a nrofarahh;S at saat three (A) MATING OL RGO ong, SETS Ai SE AW, more proTaiainy Al ast UNSS, vy N X Là cu : © Lt à FE Ls os ; Karben are aratarabhiy at ASS five mast nrataraniy ST iaast 7 altarmativaly in ta hwalve POTLISLRATIY Grarlramdy au OR ive, OST DISTGTODIV au GEST 2, Gina) Ul IQ twang Se 'INS A ot à SWE ie EE oy ed eal a ' at ML SN MS SN NS + RELI x a ï SE ve Pan, ps ee a SE cu Las en end aan gen NE antican antenantina sarracnanaing fn MRO since | coamniaves matahine at lasst ana LS Antigen SONDSDUOS COMSSDONOHG 10 MTL CIASS | COMPDIEXES matning EU 16851 ONE NN NN Ne Ks = À tes oo nag one A Le au et NÉ kn ae on hey ge een TIES A Sara ie hs vu ends BA Tag sng ira! annne aoearding TA the must han af any ane nloim DELLA ANS ste wrote ire VIS SNS ab LUA VV ANS DTERSARTAEAE OF any wine Laan LAG, WIN aR IN nrafarahiy at least 95% more orefarabiv at last 88% ofthe most cammon MLA alisles PIGGY GL TOGO V5 70, TT MOTOS GLISSE OU 20 WE LD THIOL ATI EI DRA CAES $3 ede be = d Lun dla eu tapant oan an pen ey gen HA Nistrikyu teen in the write MON der OT QIRNFHALTOQ EN ANY WONnGwige ANFALLEN, Fh) 'x SN [ oY z € x Is NINE A + Lan pe] almost we « CAIRN X Rats jee ee X Ye; x. & FRY aumthaairinn tha antinen sabunantidafe\ carrasnanaing fn AT: sisse ! pamnisvac {D} SYMNeSIZING DIE antigen DOIYDEDIQE(S) COTGIPONCING 10 MPIL Class | COMPISXSS vs A ea nent Gen as fen) determined in stan fat > GOSSES NT SSP Qi, PRACT at id PRMOR GmbH DRA SWL DD à IE T2 AS DD Eté rent vrrciecesbres Denke ba rien Et rte PMC-GCO7-P-LU 28.02 2023 Luxemburaische Patent armelduria

ANA id PN ; Hi | ins fa tha inventions esmacieine of : A ; Dical composition according to the invention comnrieïine a ; | ving the oharmaceutica! composition ascardina to the invention comprising at {oY prapanng the pharmaceutical composition sccordina to the invention LUTHNTISIS {GC} prépariig me DhartiacleuUTICAi COMMPOSMION aeooaramg i $ q ; fev RELI slase | samininene madeira at : © as a Sista de) marroomeimeiioes fn RSLS Ann | comDIexEs matehing at east One antigen POIVDODIQG(S) COTTESDONHIG to MTS Class | complaxas matehing ai IRA ONE angen DOIVDODUGS(S) COITSSPONCHIQ LO IV CIES { 9

- . « a ; whether 13 Fea § ou dowd van ey ; : ; N = SR s near nharmiannaimdiea! farminiatian past one viral antifiane nrefarahlu in à enitahle nharman sutical formulation. GAS! ONS We SDTOPS, DISTSPEDIVY IN à SUNADIE DHANMAaCOUTICat TOPNTILHA PMCR GmbH us N PAIO-OG( i 23.02 2023 Luxembourgish Palontanmeliuns PRC-O007-PLU 28.02 2023 LUXEMOUTEISCHS Faenianimaiqung EMMEN ELL

claims

1. A pharmaceutical composition for use as a medicament, in particular for use in the therapeutic and/or prophylactic treatment of a viral infectious disease, in particular in a subject or group of subjects suffering from or at risk of suffering from a viral infectious disease, comprising a pharmacologically effective amount consisting of at least one antigen polypeptide sequence comprising at least one HLA-A and/or HLA-B antigen peptide, wherein the HLA antigen peptide corresponds to at least one amino acid sequence of at least one virus transcriptome, preferably encoding a part of the virus surface proteome and preferably corresponding to a part of a viral epitope, characterized in that the antigen polypeptide sequence comprises the following framework amino acid sequence: (a) a long peptide, i.e. a compound, construct or polypeptide, the amino acid sequence of which comprises an HLA-A antigen peptide or an HLA-B antigen peptide as defined herein, wherein the amino acid sequence comprises up to 1 to 30 amino acids in addition to the HLA-A antigen peptide or HLA-B antigen peptide; and/or (b) a similarity peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined under (a) or (b), wherein the HLA-A antigen peptide or HLA-B antigen peptide defined herein has less than 100% sequence identity or similarity to the native HLA antigen peptide, such as at least 85%, more preferably at least 90% sequence identity; and/or (c) a substitution peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined under (a) or (b), wherein the HLA-A antigen peptide or the HLA-B antigen peptide as defined herein has an amino acid sequence which comprises or consists essentially of only one amino acid substitution PMCR GmbH PMC-0007-P-DE 20.03.2023 German patent application relative to the amino acid sequence of the native HLA antigen peptide; and/or (d) a tandem peptide whose amino acid sequence is as defined in point (a), comprising or consisting of at least 2 identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c); and/or (e) an overlapping tandem peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined in point (a), comprising or consisting of at least 2 identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c), in which the at least two HLA antigen peptides overlap in their amino acid sequence.

2. The pharmaceutical composition according to claim 1, wherein the antigen polypeptide corresponding to MHC class I complexes is selected to correspond to a sequence of the viral epitope of at least two different viral infectious diseases, preferably of at least three viral infectious diseases, particularly preferably of at least four different viral infectious diseases.

3. The pharmaceutical composition according to claim 1 or 2, wherein at least one antigen polypeptide of the pharmaceutical composition is a tandem and/or overlapping polypeptide consisting of at least two, preferably at least three, more preferably at least four, most preferably at least five amino acid sequences from the epitopes of at least two, preferably at least three, alternatively four different viral infectious diseases.

4. The pharmaceutical composition according to any one of claims 1 to 3, wherein preferably at least two, more preferably at least three, particularly preferably at least four, most preferably at least five, alternatively at least six, most preferably up to twelve different pharmacologically active antigens PMCR GmbH PMC-0007-P-DE 20.03.2023 German patent application

Polypeptides consisting of HLA | antigen peptides according to the present invention and matching the epitope of at least one viral infectious disease.

5. The pharmaceutical composition according to any one of claims 1 to 4, wherein the composition is preferably used for the prophylaxis and/or treatment of a viral infectious disease.

6. The pharmaceutical composition according to any one of claims 1 to 5, wherein the composition is preferably used for the prophylaxis and/or treatment of a coronavirus infectious disease, in particular a SARS-CoV-2 infectious disease.

7. The pharmaceutical composition of claim 6, wherein the HLA-A and/or HLA-B antigen peptide is an amino acid sequence selected from the group consisting of SEQ ID NO: 1-37, 59-79.

8. The pharmaceutical composition of any one of claims 6 and 7, wherein the antigen polypeptide is an amino acid sequence selected from the group consisting of SEQ ID NOs: 38-58.

9. The pharmaceutical composition according to any one of claims 6 to 8, further comprising at least one amino acid sequence comprising or consisting of an HLA-A or HLA-B antigen peptide, wherein the HLA peptide corresponds to at least one amino acid sequence in the coronavirus, such as spike S1 and S2 domain, nucleocapsid protein, envelope protein and/or ORF1ab polyprotein.

10. The pharmaceutical composition according to any one of claims 6 to 9, wherein the pharmaceutical composition comprises at least two antigen polypeptides, wherein the HLA-A and/or HLA-B antigen peptides of the at least two antigen polypeptides correspond to a combination of different parts of the coronavirus epitope, PMCR GmbH PMC-0007-P-DE 20.03.2023 German patent application which are selected from the spike S1 domain, S2 domain, the nucleocapsid protein, the envelope protein and/or the ORF1ab polyprotein.

11. The pharmaceutical composition according to any one of claims 1 to 10, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier liquid and a pharmaceutically acceptable adjuvant, carrier, diluent and/or excipient.

12. The pharmaceutical composition according to any one of the preceding claims for the use specified in claim 1, wherein the pharmaceutical composition is administered subcutaneously, intramuscularly or intradermally.

13. The pharmaceutical composition of claim 12, wherein the subject is a human.

14. The pharmaceutical composition according to any one of claims 1 to 12 for the use indicated in claim 1, wherein the HLA antigen peptides and/or antigen polypeptides corresponding to MHC class I complexes are immunogenic antigen peptides determined by means of an immunogenicity test, in particular (but not limited to) by means of Western blot, electrochemiluminescence immunoassay (ECL), ELISA techniques, ELISPOT, ICS, AFM, MS or immunodetection with microscopic analysis.

15. The pharmaceutical composition according to any one of claims 1 to 14 for the use specified in claim 1, further comprising at least one HLA-A antigen peptide and/or HLA-B antigen peptide corresponding to MHC class I complexes.

16. The pharmaceutical composition according to any one of claims 1 to 15 for use according to claim 1, wherein the antigen polypeptide corresponding to the respective subtype of the MHC class I complexes is selected from the group consisting of the amino acid sequences shown in SEQ ID Nos. 1-58 or having at least one amino acid substitution with respect to these amino acid sequences.

17. The pharmaceutical composition according to any one of the preceding claims for use according to claim 1, wherein the pharmacologically effective amount of each antigen polypeptide in the composition is in an absolute concentration

(i.e., administration dose) is in the range of at least 10 to 1,000 μg.

18. The pharmaceutical composition according to any one of the preceding claims for the use specified in the claim, wherein the pharmaceutical composition is administered as prophylaxis or as first-line therapy to the subjects or group of subjects having at least one identical HLA allele.

19. An antigen polypeptide, preferably for use as a medicament, in particular for use in the therapeutic or prophylactic treatment of viral infectious disease(s) or for a pharmaceutical composition according to any one of claims 1 to 18, comprising at least one HLA-A and/or HLA-B antigen peptide, wherein the HLA antigen peptide corresponds to at least one amino acid sequence of at least one virus transcriptome, preferably is identical, preferably encodes a part of the virus surface proteome, more preferably corresponds to a part of a viral epitope, wherein the antigen polypeptide sequence comprises the following framework amino acid sequence: (a) a long peptide, i.e. a compound, a construct or a polypeptide, the amino acid sequence of which comprises an HLA-A antigen peptide or an HLA-B antigen peptide as defined herein; the amino acid sequence further comprises up to 1 to 30 amino acids; and/or (b) a similarity peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined under (a) or (b), wherein the HLA-A antigen peptide or HLA-B antigen peptide defined herein has less than 100% sequence identity or similarity to the native HLA antigen peptide, such as at least 85%, more preferably at least 90% sequence identity; and/or (c) a substitution peptide, i.e. a compound, a construct or a polypeptide whose amino acid sequence is as defined under (a) or (b), wherein the HLA-A antigen peptide or the HLA-B antigen peptide as defined herein has an amino acid sequence which comprises or consists of essentially only one amino acid substitution relative to the amino acid sequence of the native HLA antigen peptide; and/or (d) a tandem peptide whose amino acid sequence is as defined in point (a), comprising or consisting of at least 2 identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c); and/or (e) an overlapping tandem peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined in point (a) and which comprises or consists of at least two identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c), wherein the at least two HLA antigen peptides overlap in their amino acid sequence; and/or (f) a tandem and/or overlapping tandem peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined in point (a), comprising or consisting of at least two identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c), wherein the at least two HLA antigen peptides overlap in their amino acid sequence if the amino acid sequences correspond to viral epitopes of at least two, preferably of at least three, alternatively four different viral infectious diseases. PMCR GmbH PMC-0007-P-DE March 20, 2023 German patent application

20. The antigen polypeptide of claim 19, wherein the antigen polypeptide sequence comprises the following framework amino acid sequence: (a) an amino acid sequence comprising or consisting of an amino acid sequence selected from the group consisting of SEQ ID

Nos.: 38-58; 80-90 and/or (b) an amino acid sequence having less than 100% sequence identity or similarity to the amino acid sequence according to point (a), such as at least 85%, preferably at least 90% sequence identity (as defined herein) with an amino acid sequence of SEQ ID Nos: 38-58; 80-90 and/or (c) an amino acid sequence whose amino acid sequence is as defined in point (a), comprising or consisting essentially of only one amino acid substitution with respect to the amino acid sequence(s) selected from the group consisting of SEQ ID Nos.: 38-58; 80-90 and/or (d) a tandem peptide, i.e. a compound, a construct or a polypeptide which comprises or consists of at least two identical or different peptide sequences of at least one of the sequences defined under (a) to (c), wherein the amino acid sequences are optionally linked to one another by suitable linkers (so-called oligopeptides); and/or (e) an overlapping tandem peptide comprising or consisting of at least 2, preferably 3, such as at least 4 identical or different HLA-A and/or HLA-B antigen peptide sequences (as defined herein) which encode at least two different HLA-A and/or HLA-B antigen peptides (as defined herein), wherein the at least two HLA antigen peptides overlap in their amino acid sequence.

21.The antigen polypeptide according to any one of claims 19 and 20, wherein the antigen polypeptide according to the present invention is an overlapping polypeptide which preferably contains between 2 and 10, more preferably between 2 and 8, most preferably between 2 and 6 different amino acid sequences (HLA antigen peptides) which PMCR GmbH PMC-0007-P-DE 20.03.2023 German patent application match a viral epitope corresponding to the MHC class I and/or MHC class II complexes.

22. The antigen polypeptide of any one of claims 20 to 21, wherein the antigen polypeptide is selected from the group consisting of the amino acid sequences set forth in SEQ ID NOs: 38-58; 80-90.

23. The antigen polypeptide of any one of claims 19 to 22 for use as a medicament, in particular for use in the therapeutic or prophylactic treatment of (a) viral infectious disease(s), the method comprising administering to the subject a treatment regimen comprising a pharmacologically effective amount of the antigen polypeptide.

24. The antigen polypeptide of any one of claims 19 to 23 for use as a medicament, in particular for use in the therapeutic or prophylactic treatment of a coronavirus infectious disease, the method comprising administering to the subject a treatment regimen containing a pharmacologically effective amount of the antigen polypeptide.

25. The antigen polypeptide according to any one of claims 19 to 24, which is immunogenic in the patient or group of patients, determined by an immunogenicity test, in particular by Western blot, electrochemiluminescence immunoassay (ECL), ELISA techniques, ICS, ELISPOT, AFM, MS or immunodetection with microscopic analysis.

26. A method for determining at least one antigen polypeptide according to any one of claims 19 to 25, comprising the following steps: (a) determining the amino acid sequence(s) from at least one viral genome, preferably from virus sequencing proteins containing viral epitopes presented on the viral surface, PMCR GmbH PMC-0007-P-DE 20.03.2023 German patent application

(b) comparing the amino acid sequence(s), preferably those determined according to (a), with those of at least one other related virus and determining the conserved regions in the viral genomes, (c) determining amino acid sequences which correspond to MHC class I and/or class II complexes and/or match B cells, preferably belonging to conserved viral epitope regions, preferably those determined according to (b), (d) developing synthetic antigen polypeptides which contain the amino acid sequences preferably selected according to (c) and determining the physiological and physicochemical properties, (e) preparing a composition of at least one, more specifically at least two, more preferably at least three, most preferably up to twelve antigen polypeptide(s), preferably according to (d), taking into account the HLA allele distribution of the worldwide population.

27. The method according to claim 26, wherein the viral epitopes are preferably determined from at least one viral, preferably from at least two, particularly preferably from at least three, most preferably from up to five infectious diseases.

28. The method according to claim 26 and/or 27, wherein the viral epitopes are preferably determined from a coronavirus, more preferably from a betacoronavirus, particularly preferably from a sarbecovirus, most preferably from a SARS-CoV-2 virus.

29. The method according to any one of claims 26 to 28, wherein the viral epitopes, preferably from a SARS-CoV-2 virus, with the wild type, such as the SARS-CoV-2 wild type Hu-1, and/or mutants, preferably such as the alpha (B.1.1.7) or beta

(B.1.351) or Gamma (P. 1) or Delta (B.1.617.2) and/or Omicron variant

(B.1.1.529). PMCR GmbH PMC-0007-P-DE 20.03.2023 German patent application

30. The method according to any one of claims 26 to 29, wherein the synthetic polypeptides generated in step (d) are preferably antigen polypeptides consisting of tandem and/or overlapping antigen peptides corresponding to MHC | and/or MHC |l complexes and appropriate B cell and T cell epitopes.

31. The method according to any one of claims 26 to 30, wherein at least two, preferably at least three, more preferably at least four, particularly preferably at least six, most preferably up to twelve antigen polypeptides are intended for use in a combination preparation for the prophylaxis and/or treatment of a group of subjects at risk of contracting at least one viral infectious disease.

32.The method according to claim 31, wherein the antigen polypeptides of the combination preparation preferably cover more than 95% of the HLA alleles of the world population.

33. The method of any of claims 31 and/or 32, wherein the subjects are humans.

34.The method according to any one of claims 31-33, wherein the resulting amino acid sequences are preferably selected from SEQ ID Nos: 38-58, 80-90.

35. A method for preparing a pharmaceutical composition according to any one of claims 1 to 18, comprising the following steps: (a) determining at least one, preferably at least two, more preferably at least three, particularly preferably at least five, most preferably at least 7, alternatively up to twelve antigen polypeptide(s) corresponding to MHC class I complexes which match at least one viral epitope according to the method of any one of claims 26-34, which preferably match at least 95%, more preferably at least 98% of the most common HLA alleles distributed in the world population; (b) synthesizing the antigen polypeptide(s) corresponding to the MHC class I complexes determined in step (a);

(c) preparing the pharmaceutical composition according to the invention which comprises at least one antigen polypeptide or

Contains antigen polypeptides corresponding to MHC class I complexes matching at least one viral epitope, preferably in a suitable pharmaceutical formulation.

PMCR GmbH PMC-0007-P-DE 20.03.2023 German patent application