LU103078B1

LU103078B1 - IMMUNIZATION AGAINST CORONAVIRUS

Info

Publication number: LU103078B1
Application number: LU103078A
Authority: LU
Inventors: Meik Kunz; Wolfgang Schönharting; Mari Carmen Martos Contreras
Original assignee: PMCR GmbH
Priority date: 2023-02-28
Filing date: 2023-02-28
Publication date: 2024-08-28

Abstract

The present invention relates to a pharmaceutical composition for use in the treatment or prophylaxis of a coronavirus infectious diseases, comprising at least one antigen polypeptide comprising at least one HLA peptide corresponding to MHC class I complexes, wherein the HLA antigen peptides are coronavirus exclusive and are directed against at least one MHC class I complex including combinations thereof; a pharmaceutical composition, a kit (or parts thereof), a method for determining a class I HLA peptide and/or antigen polypeptide, a method for preparing a formulation according to the invention, and the use of a formulation according to the invention for the preparation of a pharmaceutical composition for the treatment of a coronavirus infectious diseases.The present invention relates to a pharmaceutical composition for use in the treatment or prophylaxis of a coronavirus infectious diseases, comprising at least one antigen polypeptide comprising at least one HLA peptide corresponding to MHC class I complexes, wherein the HLA antigen peptides are coronavirus exclusive and are directed against at least one MHC class I complex including combinations thereof; a pharmaceutical composition, a kit (or parts thereof), a method for determining a class I HLA peptide and/or antigen polypeptide, a method for preparing a formulation according to the invention, and the use of a formulation according to the invention for the preparation of a pharmaceutical composition for the treatment of a coronavirus infectious diseases.

Description

This disclosure relates to the field of amine acids to prevent or treat coronavirus infection, In particularly io a combination agent/composition comprising of al least one, more particularly at mast two and most particularly up to 12 different synthelic peptide complexes (antigen immunization against à coronavirus while avoiding infection-enhancing antibodies, aThis disclosure relates to the field of amine acids to prevent or treat coronavirus infection, In particularly io a combination agent/composition comprising at least one, more particularly at mast two and most particularly up to 12 different synthetic peptide complexes (antigen immunization against à coronavirus while avoiding infection-enhancing antibodies, a

Hi À antigen nantide corresponding to the MHC class | comniaexes gndiar antinan ogoalvnantidaHi À antigen nantide corresponding to the MHC class | comniaexes gndiar antinan ogoalvnantida

FILA SAIS EST ESG UT SOS PLUIE STE A Gas SO à COMIDISRES SUG QUIET SOS RSR for use in the pharmaceutical composition and a method for preparing à pharmaceuticalFILA SAIS EST ESG UT SOS PLUIE STE A Gas SO à COMIDISRES SUG QUIET SOS RSR for use in the pharmaceutical composition and a method for preparing à pharmaceutical

Viruses are infectious organic structures which, as virions (voit = single Virus particle), Spread host cel {intracelluiariy), Viruses do nol exhibit independent replication or metabolism, so they ray on the metabolism of à host cell Viruses infec cells of eukaryotes (plants, fund! andViruses are infectious organic structures which, as virions (voit = single Virus particle), Spread host cel {intracelluiariy), Viruses do not exhibit independent replication or metabolism, so they ray on the metabolism of à host cell Viruses infect cells of eukaryotes (plants , find!

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Proteins and possibly other components of the virions are also synthesized by the host cell using the genes of the viral genome. In this way, naw viruses can be formed in the call and the host coll membrane with them as part of the viral envelope, Human pathogenic viruses argProteins and possibly other components of the virions are also synthesized by the host cell using the genes of the viral genome. In this way, naw viruses can be formed in the call and the host coll membrane with them as part of the viral envelope, human pathogenic viruses arg

FMOR GmbHFMOR GmbH

PMC-G005-P-LU(Z) 28.02 2023 Luxemburgische Palentanmeldung by smear infection. Coronaviruses (Orthocoronavirinae) are a group of related RNA viruses which cause respiratory tract infections.PMC-G005-P-LU(Z) 28.02 2023 Luxembourg Palent Application by smear infection. Coronaviruses (Orthocoronavirinae) are a group of related RNA viruses which cause respiratory tract infections.

Severe acute respiratory syndrome coronavirus type 2 (SARS-COV-2) is a strain of the subgenus sarbacovinus, of the genus of belacorenavinisss and was responsible for the global for the 2002-2004 SARS outbreak, These outbreaks lead to immense loss of human He andSevere acute respiratory syndrome coronavirus type 2 (SARS-COV-2) is a strain of the subgenus sarbacovinus, of the genus of belacorenavinisss and was responsible for the global for the 2002-2004 SARS outbreak, These outbreaks lead to immense loss of human He and

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PMCR GmbHPMCR GmbH

PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische PalentanmaldungPRIC-GCOS-P-LU(ZI 28.02 2023 Luxembourg Palentan declaration

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LU103078 ong or more linkers), binding molaty in such a protein or antigen polypeptide, which may optionally include one or more additional amino acid sequences that may serve as a binding moiety {ia against ons or more targets other than a T cell recaplon to provide a monovalent, multivalent, or multispecific antigen polypeptide of the invention as described herein, respectively, Such a protein or antigen polypeptide may also be present in substantially as a mixture of at least one protein or polypeptide having at least one sequence described herein (as defined herein}. 1 has been shown that a pharmaceutical composition comprising à specific combination of antigen polypeptides comprising one or more HUA antigen peptides corresponding to MHC class | complexes and MHC class I complexes disclosed herein is particularly advantageousLU103078 ong or more linkers), binding moiety in such a protein or antigen polypeptide, which may optionally include one or more additional amino acid sequences that may serve as a binding moiety {ia against ons or more targets other than a T cell recaplon to provide a monovalent, multivalent, or multispecific antigen polypeptide of the invention as described herein, respectively, Such a protein or antigen polypeptide may also be present in substantially as a mixture of at least one protein or polypeptide having at least one sequence described herein (as defined in}. 1 has been shown that a pharmaceutical composition comprising à specific combination of antigen polypeptides comprising one or more HUA antigen peptides corresponding to MHC class |

Classical methods for the treatment of infectious diseases of the invention are, for example, additives (adiuvants) Inthe context of à vaccination, the vaccine serves io spacifically activate the reaction of the immune system is exploited, which provokes an immune response in the protection against the respective pathogen, which, depending on the pathogen, can fast conjugated vaccines, DNA vascines, RNA vaccines, Tool vaccination (TOV).Classic methods for the treatment of infectious diseases of the invention are, for example, additives (adiuvants) In the context of à vaccination, the vaccine serves io spacifically activate the reaction of the immune system is exploited, which provokes an immune response in the protection against the respective pathogen, which, depending on the pathogen, can fast conjugated vaccines, DNA vascines, RNA vaccines, tool vaccination (TOV).

Thus, À is à particular achievement of the inventors to have found that for effective treatment with the antigen polypeptides used in accordance with the Invention, with different targetThus, it is a particular achievement of the inventors to have found that for effective treatment with the antigen polypeptides used in accordance with the Invention, with different target

Aan {ADR can ha avoided in the incibvicdliat in ba traatad ADE has accirrad in tha davainomant of 2 LIAL SOIT VS VUS NT DIS DIN VIS AL QU PURE, ALES HR VOS GTS TV LVI An overcoming the ADE problem led to the development of the vaccine of the present invention,Aan {ADR can ha avoided in the incibvicdliat in ba traatad ADE has accirrad in tha davainomant of 2 LIAL SOIT VS VUS NT DIS DIN VIS AL QU PURE, ALES HR VOS GTS TV LVI An overcoming the ADE problem led to the development of the vaccine of the present invention,

FMCR GmbHFMCR GmbH

PMC-CC0S-P-LU(Z) 28.02 2023 Luxemburgische Palentanmeldung immune responses throughout the viral replication cycle. The development of high fachnaiaaias in hininformativca mathamatioad modeling ana artificial intellinance (AN allows farPMC-CC0S-P-LU(Z) 28.02 2023 Luxembourgish Palestine Application immune responses throughout the viral replication cycle. The development of high fachnaiaaias in hininformativca mathamatioad modeling ana artificial intellinance (AN allows far

ILI LRAT By MG GT TIR NL, PERSIE OILS) I EAI TAG SIRE SHEARER SPORTS SAN UF RY WAILI LRAT By MG GT TIR NL, PERSIE OILS) I EAI TAG SIRE SHEARER SPORTS SAN UF RY WA

His also an cuistanding achievement of the inventors to have discoverad that a pharmaceutical composition based on antigen polypeptides is particularly effective when boin T lymphocytes {T cells for sham) and B ivmphoovtas {A calla for shah) are activated hytiham T ang B cells it SOUS TOF SNM Loca 0 PETRY 355 (82 LHD AH SHU SHR le Vaio SY ATED) ST 2 Tho belong to the hmphooyie cell group and play an important role in the human immune system, with the presence of such à cluster denoted by a 74" (CDs, COG), feature gre also called CDé4-nositive T cells or T helper cells. In normal adult Hood, CDé4+ 7 in contrast, B cells are he only calls capable of producing antibodies and, logetherwiin T cally, make up the critical component of the adaptive immune system, While T cells are involved in the cel-mediaisd immune response, 5 cells are the carriers of the humoral Immune response pharmaceutical compositions containing an absolute concentration per antigen polypeptide of preferably more than 100 ug and particularly preferably more than 500 ug are quite preferred, as this greatly intensifies the information and thus the activation and/or training of the immuneHis also a cuistanding achievement of the inventors to have discovered that a pharmaceutical composition based on antigen polypeptides is particularly effective when boin T lymphocytes {T cells for sham) and B ivmphoovtas {A calla for shah) are activated hytiham T ang B cells it SOUS TOF SNM Loca 0 PETRY 355 (82 LHD AH SHU SHR le Vaio SY ATED) ST 2 Tho belong to the hmphooyie cell group and play an important role in the human immune system, with the presence of such à cluster denoted by a 74" ( CDs, COG), feature gre also called CDé4-nositive T cells or T helper cells. In normal adult Hood, CDé4+ 7 in contrast, B cells are he only calls capable of producing antibodies and, logetherwiin T cally, make up the critical component of the adaptive immune system, While T cells are involved in the cel-mediaisd immune response, 5 cells are the carriers of the humoral Immune response pharmaceutical compositions containing an absolute concentration per antigen polypeptide of preferably more than 100 ug and particularly preferably more than 500 ug are quite preferred, as this greatly intensifies the information and thus the activation and/or training of the immune

System, In one embodiment, the concentration of a peplide is 800 ug, Accordingly, 500 ug x12 advantageous if the pharmaceutical composition comprises the adjuvants already mentioned 20 bach Ss ITM HIN rasnAnscaSystem, In one embodiment, the concentration of a peplide is 800 ug, Accordingly, 500 ug x12 advantageous if the pharmaceutical composition comprises the adjuvants already mentioned 20 bach Ss ITM HIN rasnAnsca

SL KON S MUNG raspianses. of oytiding and guanosing) is a Tol-like receptor 9 (TLR-0) agonist and is, for example, aSL KON S MUNG raspianses. of oytiding and guanosing) is a Tol-like receptor 9 (TLR-0) agonist and is, for example, a

PMCR GmbHPMCR GmbH

PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung guanine. The targeted activation of TERS by CpG oligonuciectides opens up à wide range of possibilities for using these compounds, for example, to improve the efficacy of vaccines, In the context of prophyiactic HEV vaccination, the use of CpG isads to a shortening of the addition CoG as an adipyant in Henlizaw-R also resus in a hatter respons in ivne 2 diahaticsPRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung guanine. The targeted activation of TERS by CpG oligonuciectides opens up à wide range of possibilities for using these compounds, for example, to improve the efficacy of vaccines, In the context of prophyiactic HEV vaccination, the use of CpG isads to a shortening of the additional CoG as an adipyant in Henlizaw-R also resus in a hatter response in ivne 2 diahatics

SCHON, Le as an aŒHUVANT il FISDHSAV-D SSD TESUNS HT à DOTS response NN Iype J CIADGULS, smokers, he obese, and the elderly, who generally show poorer response rates.ALREADY, Le as an aŒHUVANT il FISDHSAV-D SSD TESUNS HT à DOTS response NN Iype J CIADGULS, smokers, he obese, and the elderly, who generally show poorer response rates.

Furthermore, 1 is an oulstanding achievement of the Inventors to have discovered a nretent invention which can take advartane of hinhiv orasarvasd narts of the virus thusFurthermore, 1 is an outstanding achievement of the Inventors to have discovered a nretent invention which can take advartane of hinhiv orasarvasd narts of the virus thus

HU Lrasenl venuion WiICN can Ekg auvaiitae OF Nigny praseived Ralls OF Wie VITUS, TOUS anabiing a vaccination more effective agains! new mutations. In coronaviruses, the spike which project from the surface of the virion, The spike protein is divided into two parts, the 91 and docks io the angiotensin converting enzyme 2 (ACER) membrane protein, The 82 region mostly made up of hydrophobic amine acids. The 32 region is more conserved in coronaviruses compared to the ST region, In a preferred ambodimeant of the invention, at leastHU Lrasenl venuion WiICN can Ekg auvaiitae OF Nigny praseived Ralls OF Like VITUS, TOUS anabiing a vaccination more effective agains! new mutations. In coronaviruses, the spike which projects from the surface of the virion, The spike protein is divided into two parts, the 91 and docks io the angiotensin converting enzyme 2 (ACER) membrane protein, The 82 region mostly made up of hydrophobic amine acids. The 32 region is more conserved in coronaviruses compared to the ST region, in a preferred ambodimeant of the invention, at least

SA sine for affective entry of 2 virion in à hast coll hath funsfians are reniiired: 2) docking taSA sine for affective entry of 2 virions in a hast coll hath funsfians are reniiired: 2) docking ta

ZA SHIGE TOF SHSCHVS GNTTYy OF à VION HO à OST CSI, DOIN TUNCUHONS arg lEQUESC. 8; Joking 10 serine 2 transmentbrane protease TMPRSS2 which is able to cleave 1/32, therefore blocking sequences of the pharmaceutical composition comprises epitopes of the SARS-CoV-2 spike diycoproteit, in à more preferred embodiment, at least one of the antigen polypeptide sequences of the pharmaceutical composition comprises spitopes of the of the 82 membrane fusion subunit of the spike protein specifically rather than the 81 receptor binding domain advantageously show the same efficacy as blocking the Si-mediated receptor docking protection against different GARG-CoV-2 strains,ZA SHIGE TOF SHSCHVS GNTTYy OF à VION HO à OST CSI, DOIN TUNCUHONS arg lEQUESC. 8; Joking 10 serine 2 transmentbrane protease TMPRSS2 which is able to cleave 1/32, therefore blocking sequences of the pharmaceutical composition comprises epitopes of the SARS-CoV-2 spike diycoproteit, in à more preferred embodiment, at least one of the antigen polypeptide sequences of the pharmaceutical composition comprises spitopes of the of the 82 membrane fusion subunit of the spike protein specifically rather than the 81 receptor binding domain advantageously show the same efficacy as blocking the Si-mediated receptor docking protection against different GARG-CoV-2 strains,

FMCR GmbHFMCR GmbH

PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung such as bul nol exclusively the spike protein, which Is subject to strong mutations, can be of the invention at leas! two amine acid ssguances ars selected in such a manner, that the virus can be largeted in all reproduction steps, not only the spike glycoprotein required for membrane fusion, nucleocapsid phosphoprotein, envelops protein, surface glycoprotein andPRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung such as bul nol exclusively the spike protein, which is subject to strong mutations, can be of the invention at lease! two amine acid ssguances ars selected in such a manner, that the virus can be largeted in all reproductive steps, not only the spike glycoprotein required for membrane fusion, nucleocapsid phosphoprotein, envelops protein, surface glycoprotein and

ORKFiad polyprotein, particularly wherein sald peptides particularly comprise sequencesORKFiad polyprotein, particularly wherein balance peptides particularly comprise sequences

His a further Quistanting achtevement of the inventors to have discoverad thal à combinationHis a further Quistanting attention of the inventors to have discovered thal à combination

NOs: 38-58, preferably match à total of at least 20, More preferably at least 25, in à particular population to be immunized with the pharmaceutical composition of the invention. This allows alternative embodiment, If the combination preparation in accordance with the present invention contains the 12 antigen polypeptide sequences SEQ ID NGOs. 38-48, a total of 37 in accordance with the present invention, these hwo sequences are praferably selected io glycoprotein, nucleocapsid phosphoprotein, envelopes protein, surface glycoprotein and three sequences are selected to match at least three different regions, in a most prefered & 8: sa ad Ka Be * SOMIANRS Sara AAN TA rifferant norte at tha virus ara chosen ThaNOs: 38-58, preferably match à total of at least 20, More preferably at least 25, in à particular population to be immunized with the pharmaceutical composition of the invention. This allows alternative embodiment, If the combination preparation in accordance with the present invention contains the 12 antigen polypeptide sequences SEQ ID NGOs. 38-48, a total of 37 in accordance with the present invention, these hwo sequences are preferably selected io glycoprotein, nucleocapsid phosphoprotein, envelopes protein, surface glycoprotein and three sequences are selected to match at least three different regions, in a most preferred & 8: sa ad Ka Be * SOMIANRS Sara AAN TA rifferant norte at tha virus ara chosen Tha

EMILOGIMENT ST 12881 TOUT FSCIONS COrrasPonang 10 Quiarant Dans OT ing Virus ang CHOSSN ingEMILOGIMENT ST 12881 TOUT FSCIONS COrrasPonang 10 Quiarant Dans OT ing Virus ang CHOSSN ing

In a preferred embodiment of the invention the pharmaceutical composilion contains at least two antigen polypeptides which are selected to match vival epitopes of the coronavirus, annar to match anounh MA aliniag to archive sranhviactis nrotactian for at laast ORE, of theIn a preferred embodiment of the invention the pharmaceutical composition contains at least two antigen polypeptides which are selected to match vivo epitopes of the coronavirus, annar to match anounh MA aliniag to archive sranhviactis nrotactian for at laast ORE, of the

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LRU Ud) L002 Aad Luxemburgische Palentanmeldung peptides and/or HLA-S antigen peptides is increased thereby. In particular, the addition of ; SEE J od ANAS An ha mathe of amino acids at the C- and/or N-terminus increases the stability (depending on the method of administration eg, in the bloodstream, In muscle Tissue, in skin tissue) after administration to adminietratianLRU Ud) L002 Aad Luxembourg Palent Application peptides and/or HLA-S antigen peptides is increased thereby. In particular, the addition of ; SEE J od ANAS An ha mathe of amino acids at the C- and/or N-terminus increases the stability (depending on the method of administration eg, in the bloodstream, in muscle tissue, in skin tissue) after administration to adminietratian

SALES TIME NESDLE CARNE, in à preferred embodiment, the C-lerminus and/or N-terminus of the antigen polypeptide comprises so called "capping groups”. A preferred capping group at the N-teriinus can be an capping groups not anly increase metabolic stability but may alse increase An vitro binding affinities.SALES TIME NESDLE CARNE, in à preferred embodiment, the C-lerminus and/or N-terminus of the antigen polypeptide comprises so-called “capping groups”. A preferred capping group at the N-teriinus can be a capping groups not anly increase metabolism stability but may also increase an vitro binding affinities.

According to one preferred embodiment, one of the aforementioned amine acid Séquences of {but not mors than) 10 to 40, more preferably up to 10 to 30, Most preferably up to 10 to 25 ; HE TL TT Lr an dae pis md 165 amino acids, additionaily comprises so called "anchor amine acids” or "anchor resiques” that haraln COMprises ona or more HLA-A antigen peptides and/or HLA-B antigen peptides flanked center of the long HLA antigen peptides. Furthermore, those anchor residuss include phosnhorviated nentides. which can be recognized hv T cellsAccording to one preferred embodiment, one of the mentioned amine acid sequences of {but not more than) 10 to 40, more preferably up to 10 to 30, most preferably up to 10 to 25; HE TL TT Lr an dae pis md 165 amino acids, additionally comprises so called "anchor amine acids” or "anchor resiques” that haraln COMprises ona or more HLA-A antigen peptides and/or HLA-B antigen peptides flanked center of the long HLA antigen peptides. Furthermore, those anchor residuss include phosonic nentides. which can be recognized hv T cells

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According to one praferrad embodiment, the pharmacsutical composition comprises at least one tandem antigen polypeptide as defined in Ram (0) and/or one overlapping tandem antigen such as { one HLA-A antigen peptide and at least ons HILA-S antigen peptide or {i at least that multiple of targeting multiple HLA alleles. Thus, the inventors have found that althoughAccording to one practical embodiment, the pharmaceutical composition comprises at least one tandem antigen polypeptide as defined in Ram (0) and/or one overlapping tandem antigen such as { one HLA-A antigen peptide and at least ons HILA-S antigen peptide or { i at least that multiple of targeting multiple HLA alleles. Thus, the inventors have found that although

SO the cells and are therefore not accessible. Furthermore, this allows different genotypes to beSO the cells and are therefore not accessible. Furthermore, this allows different genotypes to be

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SE ; 28.02 2023 Luxemburgische Palentanmeldung antigen polypaplide as defined in tem (6; can be taflored in such a way that ong antigen antigen polypeptide or the overlapping tandem antigen polypeptide corresponds io an amine acid sequence located within a region of a coronavirus, such as withinSE ; 28.02 2023 Luxembourgish Palent application antigen polypaplide as defined in tem (6; can be taflored in such a way that ong antigen antigen polypeptide or the overlapping tandem antigen polypeptide corresponds io an amine acid sequence located within a region of a coronavirus, such as within

ORF1ab polyprotein, wherein the amino acid sequence of the first HLA-A and/or example corresponds 10 and thus Target a different region within à specific virus tandem antigen polypeptide or the overlapping tandem antigen polypeptide coranavirus, especially a specific/single region of a virus sub-specias (such as only tha spike 81 domain, 82 domain, nucleocapsid protein, envelope protein or use in the Targating” of multiple regions. and/orORF1ab polyprotein, wherein the amino acid sequence of the first HLA-A and/or example corresponds 10 and thus Target a different region within a specific virus tandem antigen polypeptide or the overlapping tandem antigen polypeptide coranavirus, especially a specific/single region of a virus sub-specias (such as only the spike 81 domain, 82 domain, nucleocapsid protein, envelope protein or use in the targeting of multiple regions. and/or

GB gach ong of the HLA-A and/or HLA-S antigen peptide located within the fandem an amine acd sequence located within a region of a differant coronavirus, such as and/or ORFTab polyprotein, wherein the amine acid sequence of the first HLA-A this way that first MLAA and/or HLA-B antigen peptide corresponds to and target”GB also includes the HLA-A and/or HLA-S antigen peptide located within the foundem an amine acd sequence located within a region of a different coronavirus, such as and/or ORFTab polyprotein, wherein the amine acid sequence of the first HLA -A this way that first MLAA and/or HLA-B antigen peptide corresponds to and target”

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DM oon. 28.02 2023 Luxemburgische PalentanmeldungDM oon. 28.02 2023 Luxembourg Palent Declaration

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ZU NOS: 32— SO, TN PIGIGIADIY XI RNA EL N : :TO NOS: 32— SO, TN PIGIGIADIY XI RNA EL N : :

EE ap” à AA BA RA andfar 88 anelfar x à ie a af REN IN NEO AA 44 AN SA ancdliar BR andorEE ap” à AA BA RA andfar 88 anelfar x à ie af REN IN NEO AA 44 AN SA ancdliar BR andor

Km A 1 Ay asin San anna of [KEG IAN À Spy AAS, I QUENT OU, SET LeKm A 1 Ay asin San anna of [KEG IAN À Spy AAS, I QUENT OU, SET Le

D'ETSTADIV an aning asia saqguasns DOA RIN TRY TNS, Ra, ely, OU, + 3 prayaramy CAS Any CAL SEQUENCE LI ARN 8 3D'ETSTADIV aning asia saqguasns DOA RIN TRY TNS, Ra, ely, OU, + 3 prayaramy CAS Any CAL SEQUENCE LI ARN 8 3

Ay * A VE AN cest ces entiere q i i Ahenantina Samnanoing ar canaiotinn bit 3 Ang Annan un ar nalinantina Sr 1DriSING OT consistingAy * A VE AN cest ces entiere q i i Ahenantina Samnanoing ar canaiotinn bit 3 Ang Annan un ar nalinantina Sr 1DriSING OT consisting

SX A ena = © à Compound. construct, ar sah naglids COMPRISING OF CONsSi 3 fel atandem nanticia la à COMIDOUNG, Qonsurudy, oy PSY AISI 3 A LIND 3 {3} a Tandeln AALEN, OF LAAN IE, VU 5 ; ÿ» S aE vai A à N a N es A Lio pu pu SN F at lang! ANS SANTIANPS as : ç 4 is - siffarant nantideo caniiancras nf at i ast on sSQUSNCE as i sast wo identical or differant peptide sequences of at EA VEN SAL LAL { at east hwo identicai or differ D KAARST LW CL IE 3SX A ena = © à Compound. construct, ar sah naglids COMPRISING OF CONsSi 3 fel atandem nanticia la à COMIDOUNG, Qonsurudy, oy PSY AISI 3 A LIND 3 {3} a Tandeln AALEN, OF LAAN IE, VU 5 ; ÿ» S aE vai A à N a N es A Lio pu pu SN F at lang! ANS SANTIANPS as : ç 4 is - siffarant nantideo caniiancras nf at i ast on sSQUSNCE as i sast where identical or different peptide sequences of at EA VEN SAL LAL { at east hwo identicai or differ D KAARST LW CL IE 3

OF ST DAS! WO IQanlicadl Of anrarsm MERA 3 fn FR an Bon FH. seh tha amins anti camiancas Arg aptionaily jaf Vin Hams (a) to ©) ADVE HT WIRT T SHINN RL SELL EEE Qi AOMPLIGSTICHISOF ST THAT! WO IQanlicadl Of anrarsm MERA 3 fn FR an Bon FH. seh tha amins anti camiancas Arg aptionaily jaf Vin Hams (a) to ©) ADVE HT WIRT T SHINN RL SELL EEE Qi AOMPLIGSTICHIS

JETS IN Tams Sq {X = VE HW Sad LENS SEAN NS SiN > 3 3JETS IN Tams Sq {X = VE HW Sad LENS SEAN NS SiN > 3 3

GSTINSC HT HOME LOE AN Ld QRS, NE WIR 8 A x > aa Heart tables linker ca pallsd aignonantidest and/orGSTINSC HT HOME LOE AN Ld QRS, NE WIR 8 A x > aa Heart tables linker ca pallsd aignonantidest and/or

RE fire + aash afthar hu aufahle inbare fes cailens ASS, allylRE fire + aash afthar hu aufahle inbare fes cailens ASS, allyl

RE nina #0 aan athar S SIName ETS (S0-CANHS0 OHGON x £3 HTKEA TO {ach Jing Sy RULE BERR \ died 444 } , ~ fei sai AF md load Ÿ mare nraferabh € 3 ia 3 ie SENS COMDNISINA or CONSISHINIO OT Si 8281 2 MOIS praarany 9) TO Eng ¥ EOS COMDPISING OT CON HALE SI OI DEE SACH al AA y fe an ovarianninea fandam nantida SOMDNSING OF CONSISUNG OÙ ; i € \ {8} an OVSTISDONS Lai ian PRRLNG AY ISHN RS ; = . Cu ee Tr ani di AR antinan nantile x et lab 5 ea 3 > Afferent Hi AA andar HI AR antine N nantide ~ à 8 Bam em od A \antipoail ar Aiffarar HLA-À and/or HLA-S antigen nantid 3 X ON a8 £ SEN = 3 aad $ SEETHER RGA + & aN >, SUCH 85 al 6251 4 gamical or anveren FAN . © . RA = oN a TN Oh en ne dent ed Boon Een EON ~ =, § 8 $ à GES, avd LEE ALA eye far LIES : ti 3 HP patine for at lasaet han aifferant MEALS andior HLA.RE nina #0 aan athar S SIName ETS (S0-CANHS0 OHGON x £3 HTKEA TO {ach Jing Sy RULE BERR \ died 444 } , ~ fei sai AF md load Ÿ mare nraferabh € 3 ia 3 ie SENS COMDNISINA or CONSISHINIO OT Si 8281 2 MOIS praarany 9) TO Eng ¥ EOS COMDPISING OT CON HALE SI OI DEE SACH al AA y fe an ovarianninea fandam nantida SOMDNSING OF CONSISUNG OÙ ; i € \ {8} an OVSTISDONS Lai ian PRRLNG AY ISHN RS ; = . Cu ee Tr ani di AR antinan nantile x et lab 5 ea 3 > Afferent Hi AA andar HI AR antine N nantide ~ à 8 Bam em od A \antipoail ar Aiffarar HLA-À and/or HLA-S antigen nantid 3 X ON a8 £ SEN = 3 aad $ SEETHER RGA + & aN >, SUCH 85 al 6251 4 gamical or another FAN . © . RA = oN a TN Oh en ne dent ed Boon Een EON ~ =, § 8 $ à GES, avd LEE ALA eye far LIES: ti 3 HP patine for at lasaet han aifferant MEALS andior HLA.

Es {as de ned herein}, encoding for Al ERST TWO, QITarant FILAA anaior rlsIt {as de ned in}, encoding for Al ERST TWO, QITarant FILAA anaior rls

SSQUENCES (AS GSHHEd NOraing, encoding TOr at aw LYV Le, LIESSQUENCES (AS GSHHEd NOraing, encoding TOr at aw LYV Le, LIE

SSQUENCSS (as LL HIEW SIS GRIS, wna T4 1% = EN x . \ 3 See 3 i : 3 Seat ie OA aaa peptides ix ‘ ti $ A aharain tha at ianet han HE antinan peptide = Ai articles fac Aafıinarn haraln\ wharain tha a ITRAVL VD MILLA ASUS URISSSQUENCSS (as LL HIEW SIS GRIS, wna T4 1% = EN a ITRAVL VD MILLA ASUS URIS

È ANUGEN DSDUGES (25 gained naraing VS SSI LEAS SL It WAS 8 ot ; ; b'antigen DENE VERONIKA DISSE, WHER nu restes in hair aming acid gassipnpaÈ ANUGEN DSDUGES (25 gained naraing VS SSI LEAS SL It WAS 8 ot ; ; b'antigen DENE VERONIKA DISSE, WHER nu restes in hair aming acid gassipnpa

AE Ave in tha amino acid sequence.AE Ave in tha amino acid sequence.

Qvenan HEIDI alvin aia SAYS = A N seb x a AN na 3 ee Desk aan ren an nunQvenan HEIDI alvin aia SAYS = A N seb x a AN na 3 ee Desk aan ren an nun

PHI. 305-P- 23.02 2023 Luxemburgische PatantanmaidungPHI. 305-P- 23.02.2023 Luxembourg Patent and Trade Mark Collection

PRC-0005- PLU AOL AVES 2PRC-0005- PLU AOL AVES 2

FORO LAFORUM THE

LNLN

LU103078 in one preferred embodiment, the pharmaceutical composition comprises at least one aming seid ssgusnce according to the following sequences: {a} an amine acid sequence comprising or consisting of an aming acid sequence selected 8 SY an amunn acid asnuencte kaving aac than 100% cannianes inantitv or ai a ie i ai > {0} an SIND 0 SSQUONCE NavINGg 108% Nan tuys SEQHENCE KOSTEN Qf SHAY td ine preferably at least 50%, sequence identity {as defined herein) to an amine acid sequence selected from the group consisting of SEQ ID NOs: 38 — 58; and/or {c} an amino acid sequence, wherein the amine acid sequence of which is as defined in tem (3), comprising or consisting assantially of only one amino acid substitution relative to the amino acid sequence(s) selected from the group consisting of SEQ ID {d} a tandem peptide, Le, & compound, construct, or polypeptide comprising or consisting of at isast two idanlical or differant peptide sequences of al least one sequence as inked to sach other by suitable änkers (so-called oligupeptides); andor > Ÿ me 5 antigen peptides (as defined herein), wherein the al least two HLA antigen peptidesLU103078 in one preferred embodiment, the pharmaceutical composition comprises at least one aming seid ssgusnce according to the following sequences: {a} an amine acid sequence comprising or consisting of an amine acid sequence selected 8 SY an amunic acid asnuencte kaving aac than 100% cannianes inantitv or ai a ie i ai > {0} an SIND 0 SSQUONCE NavINGg 108% Nan tuys SEQHENCE KOSTEN Qf SHAY td ine preferably at least 50%, sequence identity {as defined in) to an amine acid sequence selected from the group consisting of SEQ ID NOs: 38-58; and/or {c} an amino acid sequence, wherein the amine acid sequence of which is as defined in tem (3), comprising or consisting assantially of only one amino acid substitution relative to the amino acid sequence(s) selected from the group consisting of SEQ ID {d} a tandem peptide, Le, & compound, construct, or polypeptide comprising or consisting of at least two identical or different peptide sequences of at least one sequence as inked to another by suitable änkers (so-called oligupeptides ); andor > Ÿ me 5 antigen peptides (as defined in), whereby the very least two HLA antigen peptides

In à particularly preferred embodiment, an antigen polypeptide according to the current invention, wherein the antigen polypeptide is an overlapping tandem polypeptide preferablyIn à particularly preferred embodiment, an antigen polypeptide according to the current invention, wherein the antigen polypeptide is an overlapping tandem polypeptide preferably

SE containino hatwaan 240 8 differant amine acid senuences (HELA antigen nentides\ ao pat GORGE DELVE £10 0 HEN ann ati SÉQUENCES (MLM antigen DSDS? MECNINgG & technical effect of allowing more antigen largels io be concentrated on a small antigen acids in length, which drastically reduces the cost of the synthetic antigen polypeptides. an Annther achvantana is hat more anasifie antinane ran ha franafarvas with = wanes ivimeting +SE containino hatwaan 240 8 different amine acid senuences (HELA antigen nentides\ ao pat GORGE DELVE £10 0 HEN ann ati SÉQUENCES (MLM antigen DSDS? MECNINgG & technical effect of allowing more antigen largels io be concentrated on a small antigen acids in length, which drastically reduces the cost of the synthetic antigen polypeptides

SU ANGINGT avantage IS That Mort SDECHIE antigens Can DS ransiamead wilh 8 sings njaguon Ji the same polypeptide weight than with a non-overlapping antigen peptide, allowing a lower dose or higher immunization effect par injection,SU ANGINGT avantage IS That Mort SDECHIE antigens Can DS ransiamead wilh 8 sings njaguon Ji the same polypeptide weight than with a non-overlapping antigen peptide, allowing a lower dose or higher immunization effect par injection,

FMCR GmbHFMCR GmbH

PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung x £0 = sie = ~ 4 ~ 348 as Areale : SN + AVarian with 9 ainnis anf ‘pentidePRIC-GCOS-P-LU(ZI 28.02 2023 Luxembourg Palentanmaldung x £0 = they = ~ 4 ~ 348 as Areas: SN + AVarian with 9 ainnis anf 'pentide

GEI si meant, more than ons golvhepntide can QVEHAG WIN à SHRSC WY PS LG ; svsterred pemhacdimaent mare Man One DOINDEDUdS Can ave { Y in a preferred ASPEKTE, Ie nal © } YTGEI si meant, more than ons golvhepntide can QVEHAG WIN à SHRSC WY PS LG ; svsterred pemhacdimaent mare Man One DOINDEDUdS Can ave { Y in a preferred ASPECTS, Ie nal © } YT

HI &@ ay È | | LS ~ x x © ANNE aeHI &@ ay È | | LS ~ x x © ANNE ae

Ar more Snag antinan npanptides { ; sndenantita far avamnia two or more SHOES antigen Pepticie: i 3 srsnoine tandem polypeptides, f SANT, BWR CS TER > 7 bas an Qvaniapping anagem SC } ,Ar more Snag antinan npanptides { ; sndenantita far avamnia two or more SHOES antigen Pepticie: i 3 srsnoine tandem polypeptides, f SANT, BWR CS TER > 7 bas an Qvaniapping anagem SC } ,

Hoan VVCRSPRIS } 3 N nn “ SREY RAL se PN EY sn x AI + ; ! ans DAS Can ovarian with another i i ; UITéSDOr ding 1G VIrai anions {an Vel an WIN AREA toh MHI Class | œ MHEXES COITESDONGINQ Ww VIA SRLS Lat AHoan VVCRSPRIS } 3 N nn “ SREY RAL se PN EY sn x AI + ; ! ans DAS Can ovarian with another i i ; UITéSDOr ding 1G VIrai anions {an Vel an WIN AREA toh MHI Class | – MHEXES COITESDONGINQ Ww VIA SRLS Lat A

EOS TR ci VE XSS LATTER NING ;EOS TR ci VE XSS LATTER NING ;

MAICHING Wri 1985 : LATINA Ge 4 i N on N Alan - N Ale ii 58 N x igen nolvnantide in the spirit of the 2 an ut $$ ating an avarlanning antigen polypeptide in the TRAE LOUISMAICHING Wri 1985 : LATINA Ge 4 i N on N Alan - N Ale ii 58 N x igen nolvnantide in the spirit of the 2 an ut $$ ating an avarlanning antigen polypeptide in the TRAE LOUIS

A or I J Fs oragating an OVETISDOITS alias DOVDEI vin a à since antinen neantige thus SPERRUNG an OVETIAIN 4 ;A or I J Fs oragating an OVETISDOITS alias DOVDEI vin a à since antinen neantige thus BLOCKING an OVETIAIN 4 ;

SHS antigen MORRIE, Ns iva 4 iSHS antigen MORRIE, Ns iva 4 i

Sree ind Ese rad anSree ind Ese rad on

CUITONT INVENTION, . ; nnasiiion comprises on © : Mapa ad ead SOMNDOSHion So rise:CUITONT INVENTION, . ; nnasiiion comprises on © : Mapa ad ead SOMNDOSHion So rise:

Hstimant tha nharmacay itis ai composition comp in ong embodiment, the pi SHEERS TSE EE LS FER EH MURDERSHstimant tha nharmacay itis ai composition comp in ong embodiment, the pi SHEERS TSE EE LS FER EH MURDERS

HY ONE emtnbooiment, ESSEN S = = ORD A4 53 SA andnr RÉ mure - Fara IY NO 43 44 SN 81. 53, 534 and/or 58, mors 3) an NEY id enuepnce Nf NN IND SO, SS, OU, OF, DO, OS 8 ë NING acid sequence af SEC ID NO: 45. 4 ; ; ; {3} an amino acid sequence of ADDEN HLS 8 x, ig) Ai ail EN SOQUETS oo - ve . PTI a, X SNORE 2A 44 RN RA andtiar AR ar dhe © ; IN SON ES of SED IN NO: 43 $4, OÙ, Dé anor VS, VIREHY ONE emtnbooiment, ESSEN S = = ORD A4 53 SA andnr RÉ mure - Fara IY NO 43 44 SN 81. 53, 534 and/or 58, mors 3) an NEY id enuepnce Nf NN IND SO, SS, OU, OF, DO, OS 8 ë NING acid sequence af SEC ID NO: 45. 4 ; ; ; {3} an amino acid sequence of ADDEN HLS 8 x, ig) Ai ail EN SOQUETS oo - ve . PTI a, X SNORE 2A 44 RN RA andtiar AR ar dhe © ; IN SON ES of SED IN NO: 43 $4, OÙ, Dé anor VS, VIRE

Bela! an amino acid sequence of SEQ ID NO: 43, ‚50,Bella! an amino acid sequence of SEQ ID NO: 43, '50,

D'ETSrADiy an aming SCI SSQUENCS OT onlD'ETSrADiy an aming SCI SSQUENCS OT onl

Drareramy an amine SCI SRA . vw Anz x «Drareramy to amine SCI SRA. vw number x «

VHD ACE casnianes + {ane x nare nrefarahl bola FON saniipnne ; Ka (Are nrefarahks at lasaet Of 19, sequence . FR anse hauinn at least {854 IMS DrSTSrADIY atl ISASt WATE, SEN amino acic SSquencde Naving at past V5 70, SNS UE >VHD ACE casnianes + {ane x nare nrefarahl bola FON saniipnne ; Ka (Are nrefarahks at lasaet Of 19, sequence . FR anse hauinn at least {854 IMS DrSTSrADIY atl ISASt WATE, SEN amino acic SSquencde Navigating at past V5 70, SNS UE >

AMIN add SEATTLE PIE ay gn oe pe An N A4 EAN Ra nr FOSC ID NC AS 44 RO 84AMIN add SEATTLE PIE ay gn oe pe An N A4 EAN Ra nr FOSC ID NC AS 44 RO 84

ANH acid SBEUSNCS OF DOS Wy NW 40, 44, Hu, Si, ca fy (an defined haraim tn an SITHENO ACIC SEQUENCE OF old 1 NU 49 : : : :ANH acid SBEUSNCS OF DOS Wy NW 40, 44, Hu, Si, ca fy (an defined haraim tn an SITHENO ACIC SEQUENCE OF old 1 NU 49 : : : :

KISTREY (38 CSS” Narain; 10 an amin 3KISTREY (38 CSS” Narain; 10 an amine 3

AS BANG (ES ; | oe a ; og = re AT AS EN zen A ~ ied ; AF RN HS NEY AU Ad RNA = Ë pi ming acid SEQUENCS OF ie HL NC. 40, 44, OÙ, i if SS ara preferably an amino acid s WATE Qi QUAN TW - 2 : ? 53, 54 and/or 58, more DISTSrADIY an aming ada SeQuicAS BANG (ES ; | oe a ; og = re AT AS EN zen A ~ ied ; AF RN HS NEY AU Ad RNA = Ë pi ming acid SEQUENCS OF ie HL NC. 40, 44, OÙ, i if SS ara preferably an amino acid s WATE Qi QUAN TW - 2: ? 53, 54 and/or 58, more DISTSrADIY an aming ada SeQuic

Sd, VS J@NGAOT JG, TOITS LEE 3Sd, VS J@NGAOT JG, TOITS LEE 3

Ye RD savedYe RD saved

SA angdiner BR anciingSA anddiner BR anciing

Of ATOUT OS, anit 2 5 N N o N a ve on To six Da à bee dinOf ATOUT OS, anit 2 5 N N o N a ve on To six Da à bee din

AR N in His nr aimiianty to thaAR N in His nr aimiianty to tha

NITY a a s having lac + 3 O0 sameness ineantıbhv à DEN LU QE à ai rennanpe + AVING is SS than 100% sequertce MCTRY VI OHINS yNITY a a s having lac + 3 O0 sameness ineantıbhv à DEN LU QE à ai rennanpe + AVING is SS than 100% sequertce MCTRY VI OHINS y

ANY sn aminn api € FUTILE raving See iat SAS 3 A {D} an SING SCI NISSAN \ ’ ; ans cs Area ie sad ; K as at past 88% mars nreferabk, at 3 id = ane According ta tem {a}, such as at least 85 Fo, LE Prarsiainy à amino acid sequence SULTING IU GTS Cat), SU AXANY sn aminn api € FUTILE raving See iat SAS 3 A {D} an SING SCI NISSAN \ ’ ; ans cs Area ie sad ; K as at past 88% mars nreferabk, at 3 id = ane According to ta tem {a}, such as at least 85 Fo, LE Prarsiainy à amino acid sequence SULTING IU GTS Cat), SU AX

ANPHNG SUG SOGMGIES al 3 x So ~ x x x nu od ~ x NEY ATEN ov ied SANS af SITS ITS € iE ie ir an amino acid saguanee of [ED iDANPHNG SUG SOGMGIES al 3 x So ~ x x x nu od ~ x NEY ATEN ov ied SANS af SITS ITS € iE ie ir an amino acid saguanee of [ED iD

GH = id er ti {E S defined herein} to an an WO SCH ad AEE IAAT AMY RE Raha VN 2 least 80% sequence identity (as LAHTI PE) LL CAPI ay a i +; anot QI a ance dentiy (as à & } 45 Rast BU 0, SOYNCHLS MSN Y lai a ss - & HR] a. aGH = id er ti {E S defined in} to an an WO SCH ad AEE IAAT AMY RE Raha VN 2 least 80% sequence identity (as LAHTI PE) LL CAPI ay a i +; anot QI a ance dentiy (as à & } 45 Rast BU 0, SOYNCHLS MSN Y lai a ss - & HR] a. a

N 3 S wein Castanea af sy Bee TA oven sy IS VEN sSquEncts © y B18 84 andfor 88 more nreforahik to an STEG ang sequence of : A AA EN R4 OM Sd and/or 58, More preferably to an ai 3N 3 S wine Castanea af sy Bee TA oven sy IS VEN sSquEncts © y B18 84 andfor 88 more nreforahik to an STEG ang sequence of: A AA EN R4 OM Sd and/or 58, More preferably to an ai 3

NO: 43 4, OU, BT, 00, O4 ENO/OF og, more LEH àNO: 43 4, OU, BT, 00, O4 ENO/OF above, more LEH à

TE. Sa, SA, OU, 45, AS, 0 : x re Cie ES: anne oe - 17 AA BO 84 anniar AN" angioTE. Sa, SA, OU, 45, AS, 0 : x re Cie ES: anne oe - 17 AA BO 84 anniar AN" angio

SEQ HD NO: 43, 44 80 54 al AAA QO, anilSEQ HD NO: 43, 44 80 54 al AAA QO, anil

DER LSND SG RER AN ete 3 3THE LSND SG RER AN ete 3 3

A “ os ~ 5 tente 3 Dia inA “ os ~ 5 tente 3 Dia in

Tay + x a vraimen tt a of which in ag dafinad in x = * & herein the amino acid sequence of which SAS LTRS HI a ANS NAT san ansa Where Ng antino acid RAGT QI WIHT IR fo) ar SIMI a € se SE AWN ENN Ne ENA AN Yall N {C} an aminG DC SÉQUETILE N Le m ; it tite dieneTay + ENA AN Yall N {C} an aminG DC SÉQUETILE N Le m ; it title serves

A © 3 amina acid euhatiition g fale nf anit ana amina ani situtionA © 3 amina acid euhatiition g fale nf anit ana amina ani situation

A) Hsing or consisting assantially of only ong aming Acid substitulic fam {3} SONIDIISHIQ OF CONSISUMIG 8888 SEEN yA) Hsing or consisting essentially of only ong aming Acid substitulic fam {3} SONIDIISHIQ OF CONSISUMIG 8888 SEEN y

RSS LA}, WANTLIST ' oC ar SOND ITN ‘ in consisting of [ES IM x lactean from the aroud consisting of Sf 3D ve to ti ATHY acig saauenesi’) Selscied rom the group COTSISURS Li ASS OS Fi ative ic 1 SITENO SCH SLIDE SCHALE HT In 4 ; > raiative 10 Ine amine aad SU ©RSS LA}, WANTLIST ' oC ar SOND ITN ' in consisting of [ES IM x lactean from the aroud consisting of Sf 3D ve to ti ATHY acig saauenesi') Selscied rom the group COTSISURS Li ASS OS Fi ative ic 1 SITENO SCH SLIDE SCHALE HT In 4 ; > raiative 10 Ine amine aad SU ©

DS VARIIEREN LLY INR €DS VARY LLY INR €

CS - ~ © ENE ey ï Tae an Lad EN rears end ETN 3 S ma Sia, ah Say SON BONN € SS ; “se re prefsradiy an amino acid sequence of SEQ > 2 A pan a ss “a easy ESS WISTS [eH STE Div an SIT 10 acy SSQUE VOCS - ~ © ENE ey ï Tae an Lad EN rears end ETN 3 S ma Sia, ah Say SON BONN € SS ; “se re prefsradiy an amino acid sequence of SEQ > 2 A pan a ss “a easy ESS WISTS [eH STE Div an SIT 10 acy SSQUE VO

Aie AT AA RA RA OK Dr NAOT DO, IMS VISIO ART >Aie AT AA RA RA OK Dr NAOT DO, IMS VISIO ART >

NO: 43, 44, SU, 51, 53, 54 and/or SG, HAE | 3NO: 43, 44, SU, 51, 53, 54 and/or SG, HAE | 3

INRA QO, 44, OU, O1, AQ,INRA QO, 44, OU, O1, AQ,

VAT dd AN Rd andre AR and/or i tes 43 £341 OU SDS QI CAO x SAHVAT dd AN Rd andre AR and/or i tes 43 £341 OU SDS QI CAO x SAH

HL INL SQ, Sr, Su, Of SHOT VO, an x N ~ x i AIR ov eeu elation © < F aaivnantide comprising of consisting i fide, Le, à compound construet, of DONDSDIRIS SGMIDHSITS GE CUT SSSR ell atandem nantide je goon SAESEIE TUN, GUTISI USE, QE DUTY SG fr «day tL ant 52, SR GRATER : {ti} A1anaem MH, LE, a LA $ + 8 4 € (A RArIiApnne ac x ~ A in sequences of af least one ASouence as & t+ identicai or Sifarant peptide sequences of at least one SAYNGTLE a à at least two identical or diffar QAR SESLUS OCULICHILS çHL INL SQ, Sr, Su, Of SHOT VO, an x N ~ x i AIR ov eeu elation © < F aaivnantide comprising of consisting i fide, Le, à compound construet, of DONDSDIRIS SGMIDHSITS GE CUT SSSR ell atandem nantide je goon SAESEIE DO , GUTISI USE, QE DUTY SG fr «day tL ant 52, SR GRATER : {ti} A1anaem MH, LE, a LA $ + 8 4 € (A RArIiApnne ac x ~ A in sequences of af least one ASouence as & t+ identicai or Sifarant peptide sequences of at least one SAYNGTLE a à at least two identical or diffar QAR SESLUS OCULICHILS ç

OF at 19881 (wo OST or givers } 4OF at 19881 (where OST or givers } 4

QF Al S381 TWO IQamical ¢ PS} | : “ A A N ” PESTE des Bi € 3 Seid SANTIANSAS ars AntianallıQF Al S381 TWO IQamical ¢ PS} | : “ A A N ” PESTE des Bi € 3 Be SANTIANSAS ars Antianallı

X 3 dat {c) above, {Fr which the SM SCO SSQUEONCES arg ES a Pin Hama (A) da fm ahove in which the amino sci a AY defined in terms tait X? CANSLS VITE, avy Wwe ly 25 SSHMed IM NSS VE) 19 107 SAME,X 3 dat {c) above, {Fr which the SM SCO SSQUEONCES arg ES a Pin Hama (A) da fm ahove in which the amino sci a AY defined in terms tait X? CANSLS VITE, avy Wwe ly 25 SSHMed IM NSS VE) 19 107 SAME,

NN

AN x x ~~ Te TE = = = Hex Tend {annealed abannanticdasy anodioAN x x ~~ Te TE = = = Hex Tend {annealed abannanticdasy anodio

Tink tn sach athar Nu suitable nkars (SO-CHHSO SHOUPEPHOSSE ARLONTink tn sach athar Nu suitable nkars (SO-CHHSO SHOUPEPHOSSE ARLON

Xe tn SSON € SE DY SURGE HKS (30-03 >Xe tn SSON € SE DY SURGE HKS (30-03 >

HENKE 10 SACN CINE! KV ola YEN X - a x - EA A 3 env bed] af at ianet 7? mnra sreferabiv 2 tides comprising or consisting OT AT 1088 £, MOTS D'ETOI BA : inn tandem nantisdle samnric NO OF CONSIS Un OT € $ , i fa) an overlanninn tandem SMS COMDrSHMO OF COI AHENKE 10 SACN CINE! KV ola YEN X - a x - EA A 3 env bed] af at ianet 7? mnra sreferabiv 2 tides comprising or consisting OT AT 1088 £, MOTS D'ETOI BA : inn tandem nantisdle samnric NO OF CONSIS Un OT € $ , i fa) an overlanninn tandem SMS COMDrSHMO OF COI A

LE) SN QVERalBig GATICIGHTS PONURE } 3LE) SN QVERalBig GATICIGHTS PONURE } 3

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SSQUETICSS (as OST J Ergin, SNCOONS TOISSQUETICSS (as OST J Ergin, SNCOONS TOI

S DC SEEN DIESES, 3 È ;S DC SEEN THIS, 3 È ;

Sequerctes ARE GOT © 3: = > N ru Li À anfinan renntiiNae = © © arain in the at isast hwo HLA antisen nantig 33 tid ‘as defined herein) wharain ie ST IGASi wa HILA SIN PUPLRSS 3H 5 antigen peptides (as defi SU KINDES, WEIR RY LIE ol IR USSSequerctes ARE GOT © 3: = > N ru Li À anfinan renntiiNae = © © arain in the at isast hwo HLA antisen nantig 33 tid 'as defined ein) wharain ie ST IGASi wa HILA SIN PUPLRSS 3H 5 antigen peptides (as defi SU KINDES , WEIR RY LIE ol IR USS

BF antigen pOpnies (as GEHSU HR ès wd EY SIESTABF antigen pOpnies (as GEHSU HR ès wd EY SIESTA

Arbon im thaï ir si SANTIANSS rt hair amino acid ssouer teArbon in thaï ir si SANTIANSS rt hair amino acid ssouer te

GVENAD NT TION am à OLA SOLUCEIGE.GVENAD NT TION on à OLA SOLUCEIGE.

OVSTIRD IT INS ating ACI SE UL ; CR GmbH a x Luxemburaische PalentanmeldunaOVSTIRD IT INS ating ACI SE UL ; CR GmbH a x Luxembourg Palentan Registration

Pts. ap. 28.02 2023 LUXSIMDUIGISCHE PatontarimequridPts. ap. 28.02 2023 LUXSIMDUIGISCHE Patontarimequrid

P-L UE) COQ EUP-L UE) COQ EU

DAACONNS. DL LIDDAACONNS. DL LID

PMIC-SGUS-PLUTZ)PMIC-SGUS-PLUTZ)

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Ls à nrafarran sae $ Toa «2 or ; A NLs à nrafarran sae $ Toa «2 or ; A N

À nrefarran aanant af tha nraçcant invantinr su, si à $3 £503 ë iÀ nrefarran aanant af tha nraçcant invantinr su, si à $3 £503 ë i

A preferred aspect of the present invention are HLA antigen peptides corresponding to MHC $ ISPECT OF INS rasan NVenan arg FILA SMUGSN Depules Comasponaing io Mint. bas } Yl singe | eamalavas in > i: : &, N 34 ç ç sisae | paminisvas LA Hnartipniss far san in ha trasimrant X { i = N class | complexe in nartiquiar for use in the treatment or oranhviaxis of à coronavirusA preferred aspect of the present invention are HLA antigen peptides corresponding to MHC $ ISPECT OF INS rasan NVenan arg FILA SMUGSN Depules Comasponaing io Mint. bas } Yl singe | eamalavas in > i: : &, N 34 ç ç sisae | paminisvas LA Hnartipniss far san in ha trasimrant X { i = N class | complexe in nartiquiar for use in the treatment or oranhviaxis of à coronavirus

LOIS ARS, HT DEGLI IUT USS HT ine TESIMEmM Of Propnviaxis OF à COTONEVHUS } \ OTGCHEVHUSLOIS ARS, HT DEGLI IUT USS HT ine TESIMEmM Of Propnviaxis OF à COTONEVHUS } \ OTGCHEVHUS

RO RE ; SAME ALIM: infeontiniia icaste euch ace SARS OAL in à narenn £ 3 ; iRO RE ; SAME ALIM: infeontiniia icaste euch ace SARS OAL in à narenn £ 3 ; i

INfECHOUS disease such a8 SARS-CoV-Z2 In a parson or group of persons who has contracted 18 UCN 88 DARS-LOV-L IT A Person OF QTOUD OT parsons wind Nas comradiedINfECHOUS disease such a8 SARS-CoV-Z2 In a parson or group of persons who has contracted 18 UCN 88 DARS-LOV-L IT A Person OF QTOUD OT parsons wind Nas comradied

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PIS àl ISK OF COMradiing à COTONAVITUS SUCH a8 SARS-LOV-E anor TOF à phamadaiiiea a QRRAVITUS SUCH AS SARS-LOV-L SNOT TOT à PROG LANGEN = SATUS REN See eel tn diam IN ; $ im SE i composition according io the isvantinin uharain tha di ALA anti $10 au badd en 3PIS àl ISK OF COMradiing à COTONAVITUS SUCH a8 SARS-LOV-E anor TOF à phamadaiiiea a QRRAVITUS SUCH AS SARS-LOV-L SNOT TOT à PROG LANGEN = SATUS REN See eel tn diam IN ; $ in SE i composition according to the isvantinin uharain tha di ALA anti $10 au badd en 3

SS composition according to the invention wherein the HLA-A antigen peantides or HLA H antigen { GLS INS INVENTION, Waa Ing FILA-A Gnligen DODTGES OP PILA-S Antigen > at . os 4e ; nantides ara nratfarahie eslestent feoam Rha Arai eon sists a : NSSS composition according to the invention wherein the HLA-A antigen peantides or HLA H antigen { GLS INS INVENTION, Waa Ing FILA-A Gnligen DODTGES OP PILA-S Antigen > at . os 4e ; nantides ara nratfarahie eslestent feoam Rha Arai eon sists a : NS

DODIIQES ars DISTarapily SSIs wom INS ground CONSISTIIS OT ing ammo RAIN APNE AA hunDODIIQES ars DISTarapily SSIs wom INS ground CONSISTIIS OT ing ammo RAIN APNE AA hun

LE grorerady Seiad wom ing group COHSISIITG anne SHINO AGIA SSOQUEONCES SHOW = X 5 oT in Table 1.0 er which avis at masi PUR Nain ara fin hr ao ans x niet + Sr pds ue in Tables 1-5 or which have al least one mutation, preferably an aming acid substitution, willLE grorerady Seiad wom ing group COHSISIITG anne SHINO AGIA SSOQUEONCES SHOW = preferably an amic acid substitution, will

RAVE QU HEISE WHE TNLRSUIQNE, POIGTODIN an AMINO AGIC SUDSIRUTION, Wilh raanant ia ana of thaos amina sei cs raanact in 2 ofthess amino ack saguaneasRAVE QU HEISE WHE TNLRSUIQNE, POIGTODIN an AMINO AGIC SUDSIRUTION, Wilh raanant ia ana of thaos amina sei cs raanact in 2 ofthess amino ack saguaneas

VESDECT 10 ONS OF Nese amine adi SOQUONCES.VESDECT 10 ONS OF Nese amine adi SOQUONCES.

Particulariy preferred herain is the use of the foregoing HLA antigen pepntid if tiParticularly preferred method is the use of the foregoing HLA antigen pepntid if ti

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PORE] USE I à MSINeG OF TEAUNG oARD-LOV-£ IM à patent OF group of patiems > } © ; X ; TT ; ; ; faving nt lanei ane iNarviinat WI À allais it Shan jai find having at least one identical HLA allele the method comorising adminisierina/ BfPORE] USE I à MSINeG OF TEAUNG oARD-LOV-£ IM à patent OF group of patients > } © ; X ; TT ; ; ; faving nt lanei ane iNarviinat WI À allais it Shan jai find having at least one identical HLA allele the method comorising adminisierina/ Bf

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SEEN Sms ad Sea care NT étre À ; Li À i i; amount comprises at least one of the forscoina Li À antinan santidaoSEEN Sms ad Sea care NT étre À ; Li À i i; amount comprises at least one of the forscoina Li À antinan santidao

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AN Eres AAN NS TEE + ve Sead ; Ai © ;AN Eres AAN NS TEA + ve Sead ; Ai © ;

DRHSTMISSAUÉSSE coamnnsifion TA à suinect anciar oro AE varinianéeDRHSTMISSAUÉSSE coamnnsifion TA à suinect anciar oro AE varinianée

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Le GE, VS > 25.Le GE, VS > 25.

In Ana emhantiment the antinen nafunantiiare ç Wi : 5 in ong amhadimant the antinen nalynantirda(e Kr me x a : : - ; in one embodiment, the antigen polvpeptide(s), preferably as used in the pharmaceutical ‚ MS anugen DOYVDEDUGE(S), Dratarally a8 used M mg pnarmadauticalIn Ana emhantiment the antinen nafunantiiare ç Wi : 5 in ong amhadimant the antinen nalynantirda(e Kr me x a : : - ; in one embodiment, the antigen polvpeptide(s), preferably as used in the pharmaceutical ' MS anugen DOYVDEDUGE(S), Dratarally a8 used M mg pnarmadautical

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NOR RR … RANOR RR … RA

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RAM IRNAG SAMIR SN Ar onngiating AT an LH AA ar NI AR +i ; ÿ ïRAM IRNAG SAMIR SN Ar onngiating AT an LH AA ar NI AR +i ; ÿ ï

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SSI NISS ETES Aeration SO CUIDISINIGG OF all Muses Pilsen a gen 060108, wherent INS Mild 3 OMPrISMG OF CONSISUNG OF an MLACA OF MLÄA-D anugen pspiids, WASTSINT INS MLA ba ; . nantide sarreennnne arafarsakliu le jidantiral + a à: ç N Da peptide corresponds. preferably is identical io at [east one amino acid sequence in the pe SDONSS, profaraiiy 15 IOSTHICEE 10 8 6351 ONG aming acid sequence N MOSSI NISS ETES Aeration SO CUIDISINIGG OF all Muses Pilsen a gen 060108, wherent INS Mild 3 OMPrISMG OF CONSISUNG OF an MLACA OF MLÄA-D anugen pspiids, WASTSINT INS MLA ba ; . nantide sarreennnne arafarsakliu le jidantiral + a à: ç N Da peptide corresponds. preferably is identical io at [east one amino acid sequence in the pe SDONSS, profaraiiy 15 IOSTHICEE 10 8 6351 ONG amino acid sequence N MO

PATANQUITES Such ac enika 1 ann QD Samaln 3 iol foriPATANQUITES Such ac enika 1 ann QD Samaln 3 iol fori

COTONSVITUS, such as snike 81 ang 82 domain Selanne anaes sratair NENA FL ; das by tiCOTONSVITUS, such as snike 81 ang 82 domain Selanne anaes sratair NENA FL ; that by ti

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ANA DONVDIQIGI, FISGIDQNIV, ing MLAF A OF mi Ant ANE EATEN FY NANI AFFEN aS AF sanoiatinegANA DONVDIQIGI, FISGIDQNIV, ing MLAF A OF mi Ant ANE EATEN FY NANI AFFEN aS AF sanoiatineg

LOY Si, FTSTSTADIY, INE MLAA OF FLAT anigen DODUGS COMPriSes OF CONSISTIQ = y X A TER an £ om nD Et Ps ET af AF an smina anisl Sarianna ne Asafinan haraı “NN $, ai 4 3 : of an amino acid ssaousnte as defined herein, more praferablv. the amino acid senusnee isLOY Si, FTSTSTADIY, INE MLAA OF FLAT anigen DODUGS COMPriSes OF CONSISTIQ = y , more praferablv. the amino acid senusnee is

FAL SELLER ah CONNIOU NETS, NUS praisianty, ing STD adi SSOUETCS IS salantart fran Fa sue in ments a af OY IM AIT 4 a 0e > stactad fram the araun consisting af SED IN NOT 41... 27 89 sa selected fro he aroun consisting af SE DNO 37 8 7FAL SELLER ah CONNIOU NETS, NUS praisianty, ing STD adi SSOUETCS IS salantart fran Fa sue in ments af OY IM AIT 4 a 0e > stactad fram the araun consisting af SED IN NOT 41... 27 89 sa selected fro he aroun consisting af SE DNO 37 8 7

SHELIA WOM ING Group CONSISURG OF DIN IL NL I 04, 99 — 25SHELIA WOM ING Group CONSISURG OF DIN IL NL I 04, 99 — 25

RATS madRATS mad

PRMOR GmbHPRMOR GmbH

RAR. DE EN - -RAR.DE EN - -

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COME ERNE ARMATrIRAS ar Ba 4: i ni I ; : aang & PMNMNATIRAS an afaramantinnets anmine eu pat oy | si ir sequence comprises an aforementioned amino acid sequence the amino acid i PriSSS an aramenudngd amin SCI SSGUSNCS, INS ammo aaa a0 casatiiancs nrafarably further cominriesa un + fad med ét y 4 4 THCOME ERNE ARMATrIRAS ar Ba 4: i ni I ; : aang & PMNMNATIRAS an afaramantinnets anmine eu pat oy | si ir sequence comprises an aforementioned amino acid sequence the amino acid i PriSSS an aramenudngd amine SCI SSGUSNCS, INS ammo aaa a0 casatiiancs nrafarably further cominriesa a + fad med ét y 4 4 TH

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MC-CO0S-P-LUZ) Pa OD PAT rs ent Keen hess + en (2) 28.02 2023 Luxemburgische PalontanmeidungMC-CO0S-P-LUZ) Pa OD PAT rs ent Keen hess + en (2) 28.02 2023 Luxembourgish palontan avoidance

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LU103078 {c} an antigen peptide having an amine acid sequence comprising or consisting essentially of only one amino acid substitulion relative lo the amine acid sequences) selected 34, SE, wherein when the amino ack! sequence comprises an aforemantionad amine more than 1 to 30, more preferably 110 20, most preferably 110 18 amino acids; and/orLU103078 {c} an antigen peptide having an amine acid sequence comprising or consisting essentially of only one amino acid substitution relative lo the amine acid sequences) selected 34, SE, wherein when the amino ack! sequence comprises an aforemantionad amine more than 1 to 30, more preferably 110 20, most preferably 110 18 amino acids; and/or

Forehand ale a arises at nas! ana antigen nentide ag define in dams fm fo fa above: oi WHICH SOMPMSSS EL ERS One QG PCT AS GTS IL Hi AVIS (QUES A *; and/or {2} a tandem peptide, LE, à compound, construct, or polypeptide comprising or consisting peptide and one HLA-A and/or HLA-B antigen peptide, preferably both as defined in described under (@) or (dd) In the case that the MLA-A antigen peptides as defined under (€) {c), may further comprise up fo {but not more than) 1 to 30, more preferably 1 to 20, most that the stability of the HLA-A antigen peptides is increased thershy. In particular, this degradation from the C- and/or N-terminus after application, in a particular embodiment of the present invention, one of the aforementioned amino acid sequences, in particular as defined in Kems (a to (©), comprises of preferably up to (pui not + . fd not more than in 70 more orafarabiv Tin 5 most nrefera hy 43m 109 minoForehand ale a arises at nas! ana antigen nentide ag define in dams fm fo fa above: oi WHICH SOMPMSSS EL ERS One QG PCT AS GTS IL Hi AVIS (QUES A *; and/or {2} a tandem peptide, LE, à compound, construct, or polypeptide comprising or consisting peptide and one HLA-A and/or HLA-B antigen peptide, preferably both as defined in described under (@) or (dd) In the case that the MLA-A antigen peptides as defined under (€) {c) , may further comprise up fo {but not more than) 1 to 30, more preferably 1 to 20, most that the stability of the HLA-A antigen peptides is increased therhy. In particular, this degradation from the C- and/or N-terminus after application, in a particular embodiment of the present invention, one of the mentioned amino acid sequences, in particular as defined in Kems (a to (©), comprising of preferably up to (pui not + . fd not more than in 70 more orafarabiv Tin 5 most nrefera hy 43m 109 mino

COMPRISE UR tO {DUT HOT MOIS NAN 1 10 ZU, More DISTSTADIY 110 D MONT DrOTSTADIY 110 TU AO acids. This has the particular advantage that more than one viral epitope can be targeted with a single amino acid sequence in accordance to the present invention, thus increasing a potential S/T cell response.COMPRISE UR tO {DUT HOT MOIS NAN 1 10 ZU, More DISTSTADIY 110 D MONT DrOTSTADIY 110 TU AO acids. This has the particular advantage that more than one viral epitope can be targeted with a single amino acid sequence in accordance with the present invention, thus increasing a potential S/T cell response.

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PMC-0GOS-P-LU(Z) 28.02 2023 Luxemburgische Patentanmeldung amPMC-0GOS-P-LU(Z) 28.02.2023 Luxembourg patent application on

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HLA-A and/or HLA-B antigen sequences, it has been found to be particularly advantageous to at isast within the genus (befacoronaviruses), bul at least different mutants within a subgenus polypeptides according to the invention fo bs used not only for the treatment of à Specific virus types {such as SARS-CoV 1, SARS-COV 2, MERS-COV), bul moreover for the uss in theHLA-A and/or HLA-B antigen sequences, it has been found to be particularly advantageous to at isast within the genus (befacoronaviruses), but at least different mutants within a subgenus polypeptides according to the invention fo bs used not only for the treatment of à Specific virus types {such as SARS-CoV 1, SARS-COV 2, MERS-COV), bul moreover for the uss in the

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VENTION IS SUNADIS TOM Iw § °VENTION IS SUNADIS TOM Iw § °

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Wandaaimatt OF OT ooWandaaimatt OF OT oo

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X 5 ag figen paptide degrad VIS CAS Oo "AR > ; Ÿ i ed € ISN DSDUCS Qegradasiion N i i & OF ragucad antigen papa @ SAA t H cal advantage of TRLALILG QR} Ÿ"

CHE aadvaniags OT TSQUOS 34CHE aadvaniags OT TSQUOS 34

USL a SALSA LG N & Ss th AN x + se denis x Sie the arıhiant oT ; 3 y deoliverar in the auh Qt,USL a SALSA LG N & Ss th AN x + se denis x Sie the arihiant oT ; 3 y deoliverar in the auh Qt,

MN the of tige not peptide IS SIOWIV Qaiiveraq to INS VASTE thus 18 antigen DONVDODUQS IS SiN ¥MN the of tige not peptide IS SIOWIV Qaiiveraq to INS VASTE thus 18 antigen DONVDODUQS IS SiN ¥

US, LEIS THLE POV RAG = an 4% + + + x Aen à X a t nine ; lace | samnleves ananas > 3 MS _ i anding to Adi Le Dass | COMMIEXES and/or cu Ÿ Ÿ if 8 tine centiries COTTESDONGHIQ 10 Mir Gigs hace 3 mt Lit À antinan nantica € drrespondine 1 ! mien Ts ri SUIS) M MURS LAM S Ss 1 { à aA x $ POA in | X in one SMDOCHTISNT, MN AN SUR > > 1 | / iR PE az + at snd nn a + 2, ates far inlectinn ÿ re tn ha farmniatead far ini action. idaa are formidated nr are tn be formulated foi imiectic ci i an OAVOSDTK SS SPS IMMA OF ars 10 DS TO LH Shel he IGEN DOYDEDTQOES arg ToOrThiiaieo & aide DONVDEDHOSS are Toi X ne ANNE PASAT + > > Luxemburgische PatantanmaidungUS, LEIS THLE POV RAG = an 4% + + + x Aen à X a t nine ; lace | samnleves pineapple > 3 MS _ i anding to Adi Le Dass | COMMIEXES and/or cu Ÿ Ÿ if 8 tine centiries COTTESDONGHIQ 10 Mir Gigs hace 3 mt Lit À antinan nantica € drrespondine 1 ! mien Ts ri SUIS) M MURS LAM S Ss 1 { à aA x $ POA in | X in one SMDOCHTISNT, MN AN SUR > > 1 | / iR PE az + at snd nn a + 2, ates far inlectinn ÿ re tn ha farmniatead far ini action. idaa are formidated nr are tn be formulated foi imiectic ci i an OAVOSDTK SS SPS IMMA OF ars 10 DS TO LH Shel he IGEN DOYDEDTQOES arg ToOrThiiaieo & aide DONVDEDHOSS are Toi X ne ANNE PASAT + > > Luxemburgische Patantanmaidung

A 28.02 202 LUXE TD UT CHSCTA 28.02 202 LUXE TD UT CHSCT

MG COOP EOSMG COOP EOS

DAAMLANASLDLE LIE A NyDAAMLANASLDLE LIE A Ny

PMO-OG0S-$ LANL ae 3 sed fee faxes and/or iQ class complexes and/0 fing to MHC class | compPMO-OG0S-$ LANL ae 3 sed fee faxes and/or iQ class complexes and/0 began to MHC class | comp

GRIMME 10 ANG CIS \ rasnonding to AA a de comespondine JR tigen peptide corraspo q ausGRIMME 10 ANG CIS \ rasnonding to AA a de comespondine JR tigen peptide corraspo q aus

Themen pep ee fad for intramusou ‘ à iL À anti JOT AT Co | mi iment the HLA SHUN pats | + tormatated ©Topics pep ee fad for intramusou ‘ à iL À anti JOT AT Co | mi iment the HLA SHUN pats | + tormatated ©

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HONS ied or àHONS ied or à

N Hoss are formudsied € vosotlides are fo igen polypeptides the antigen D AVES ne aniige { in a ep nNN Hoss are formed € vosotlides are fo igen polypeptides the antigen D AVES ne aniige { in a ep nN

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Hiorformutlation ti i CONTIDOSITION VTOTITIQIESHiorformutlation ti i CONTIDOSITION VTOTITIQIES

SEUTCE COMPOSESECOND COMPOSE

: [EY IMRCEUNCS Lol X Sn © the nharmaceuti Co hodiment, the pharmac on à vaccine in one embodiment, Ih i tior/formulation is 8 y ni € wo SSID - WANNE NA nw Ai NS x AA ai aro fe tical compositio: [EY IMRCEUNCS Lol

Ï \acEuticai LA th pharmaceutical > {, the pharmaceuti ment, the pharm | Bh mbodiment, the 7 freryi mia a = Ons SNDOCHTIEN I = LANE QT I en > MIE dan DONDE IS TCÏ \acEuticai LA th pharmaceutical > {, the pharmaceuti ment, the pharm | Bh mbodiment, the 7 freryi mia a = Ons SNDOCHTIEN I = LANE QT I en > MIE dan DONDE IS TC

Vor the antigen PAYS tides and/or the SHEET À 3Before the antigen PAYS tides and/or the SHEET À 3

LA ntigen DERE ahdO! the HLA antigen pept 2 3 ne at the HL \ ang § 2 smpodiment, the mi in Done EMDOCHLA NTENTEN DERE ahdO! the HLA antigen pept 2 3 ne at the HL \ ang § 2 smpodiment, the mi in Done EMDOCH

Sistas inted as particles. fated as particiss a formulated as part _ is to be formulated as i a 1810 De TON I ocSistas inted as particles. fated as particiss a formulated as part _ is to be formulated as i a 1810 De TON I oc

SDS 43 od en described herein, ï anticle describes tigen peptide desSDS 43 od en described in, ï anticle describes tigen peptide des

HLA antioer SOS aHLA anti-SOS a

N pr STE ANEN YN > AN pr STE ANEN YN > A

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N Ons prete 4 en SETS S LLCS waN Ons prete 4 en SETS S LLCS wa

HE Ong DI t of the pharmacs anhviactioHE Ong DI t of the pharmacs anhviactio

HA y ion sart of the Dharm 2 si > aranhviactiHA y ion sart of the Dharm 2 si > aranhviacti

Cry Win nae ANS ÿ ialhy far tha OFT de HR IS DEN 0 cialis far the : i \ © ı polypeptide FR DE isease, aspecially for # {Cry Win nae ANS ÿ ialhy far tha OFT de HR IS DEN 0 cialis far the : i \ © ı polypeptide FR DE isease, especially for # {

HR antinan SS . SS dispase ESPECI 3HR antinan SS. SS dispase ESPECI 3

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AN DORT a © \ sneopitte Ah LG a © a) PINS + Ç § oad SR HUSOILIE | A oe 5 ske X tas ich es ‘ed at an AN 3e I om sers at an O0 va, oreforabiy frAT THERE a © \ sneopitte Ah LG a © a) PINS + Ç § oad SR HUSOILIE | A oe 5 ske X tas i es ‘ed at an AN 3e I om sers at an O0 va, oreforabiy fr

A ACT HSISTSC a 1000 un, preferai \ we sme tr à TIMMY var MN 3 2 Ta DE AO . A ten O00 ug, { t aiment may Des a fram 10 to 1 SAE HN,A ACT HSISTSC a 1000 un, preferai \ we sme tr à TIMMY var MN 3 2 Ta DE AO . A ten O00 ug, { t aiment may Des a fram 10 to 1 SAE HN,

PE a ‘à + rande Tom TL : MEN ey um net 1 à range tro 280 us. UNPE a ‘à + edge Tom TL : MEN ey um net 1 à range tro 280 us. U.N.

WEE in Hosa in oa SE up to 250 us, unWEE in Hosa in oa SE up to 250 us, un

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AIAN SOY vay SUN as Sy x Aminisiered, In > AVR A uit AGH } be adminisierec i 300 to BLO MU; + nay He adminsAIAN SOY vay SUN as Sy x Aminized, In > AVR A uit AGH } be administered i 300 to BLO MU; + nay Hey admins

So Fes SN MG AL FINE RIRE ae may be adi farainhe TON SU t cen may ~ arafarably from 3 Lu 10 550 00 1 (07 #8 LL. to SHO va or ud to HF Fu eatSo Fes SN MG AL FINE RIRE ae may be adi farainhe TON SU t cen may ~ arafarably from 3 Lu 10 550 00 1 (07 #8 LL. to SHO va or ud to HF Fu eat

N 150 ui, UD to 800 ug or u amiodimentN 150 ui, UD to 800 ug or u amodiment

A 5 x ANDY aie Lad AW GS Has à ci ART Saiment,A 5 x ANDY aie Lad AW GS Has à ci ART Saiment,

UD 10 450 US, St ation In ane mb ‘ ION aa on WS SSL A x mintratinn in on st ANN IN, MT a Ne at à, LS CO AUS MM, N des aodministratiUD 10 450 US, Station In ane mb ‘ ION aa on WS SSL A x mintratinn in on st ANN IN, MT a Ne at à, LS CO AUS MM, N des aodministrati

PASSES Lae Dir LL SL Pi mais dacs BOTTIN N to 350 ug, LES À ‘ to a single dose ac onPASSES Lae Dir LL SL Pi mais dacs BOTTIN N to 350 ug, LES À ‘ to a single dose ac on

WE SOU VU tion relates to a SANTOS 18 dr more Baaster ‘ POSER TEES lv ane Let TTL NS ne eT Co Sms Hon penn ed SAS NI A lisant tha SEN | Da on poosiment, fhe ave imina dose followed AY . © or shee tion of à priming dose folic ae TA tn 483 LE amu inistration of a prin ing os days or 14 10WE SOU VU tion relates to a SANTOS 18 dr more Baaster ‘ POSER TEES lv ane Let TTL NS ne eT Co Sms Hon penn ed SAS NI A lisant tha SEN | There on poosiment, fhe ave imina dose followed AY . © or shee tion of à priming dose folic ae TA tn 483 LE amu inistration of a prin ing os days or 14 10

N iministration LT a Tin O8 davs QF 14 13 . hen SOHTHNISITATION 3 on cvs [ ce tO he SONTMIST ete 28 daN iministration LT a Tin O8 davs QF 14 13 . hen SOHTHNISITATION 3 on cvs [ ce tO he SONTMIST ete 28 da

Pandang Tw HE AVANT drminisierad ; te ror hi Co EM any MALTY GE © Wanton rai AS : Aa Ra a mini 0 me iar dose may de acPandang Tw HE AVANT drminisierad ; te ror hi Co EM any MALTY GE © Wanton rai AS : Aa Ra a mini 0 me iar dose may de ac

WIE INVEST first booster dose mayHOW TO INVEST first booster dose may

N "the first hoosier d i OF INE HTSi DOC roose OF [SEL ERTSN "the first hoosier d i OF INE HTSi DOC roose OF [SEL ERTS

The booster doses or i doses. The booster enThe booster doses or i doses. The booster en

LE EH FETS LID.IT'S ALL RIGHT.

WISE H X AT Has arming do imaimietratinn OF INS Drm 9 following administration of i mn à oleae following lai | ooWISE H oo

A SIRS ARAL IS ) _ | N a LEN TON : crie Daren, OSTEN 3 - | ide described hers 3 spiide describes tigen peptide desA SIRS ARAL IS ) _ | N a LEN TON : crie Daren, EAST 3 - | ide described hers 3 spiide describes tigen peptide des

HLA antigei SAS N ; à À anf THE RSE ooHLA antigei SAS N ; à À anf THE RSE oo

Ha Taio 5 A TALI 3 ; a N : rt, each single HLA antio eee a acnlimaean Se DIL a he theres { } ambodi Gin, : AOOSiHonN Tor in ferred embodim : al composition: a nreterreo Si cacatiguent oe MOST ; © ce h i or SAE SSE HSH RL Ÿ o peHa Taio 5 A TALI 3 ; a N : rt, each single HLA antio eee a acnlimaean Se DIL a he theres { } ambodi Gin, : AOOSiHonN Tor in ferred embodim : al composition: a nreterreo Si cacatiguent oe MOST ; © ce h i or SAE SSE HSH RL Ÿ o pe

NT One Dretei Etes OHErmacSutioai raceNT One Dretei Etes OHErmacSutioai race

HE UNDE À bis part of the pharma oo erase . IE LÉ ve Da NPN LA NN 3 NN N fe then tide if it is part speciale far th peptide, MN IS € ° Seesen :HE UNDE À bis part of the pharma oo erase . IE LÉ ve Da NPN LA NN 3 NN N fe then tide if it is part speciale far th peptide, MN IS € ° Seesen :

H antigen peptide, if | Ï tous disease, especially o SCH Samgsn N “à ati NSS, ooH antigen peptide, if | Ï tous disease, especially o SCH Samgsn N “à ati NSS, oo

NEY RAT SAS Ÿ WEIS Ives Tous Qi me 20 Sac = fa coronavirus infection ie orationNEY RAT SAS Ÿ WEIS Ives Tous Qi me 20 Sac = fa coronavirus infection ie oration

X fof a coronavirus nite as fant of a LAST sr dose ot heX fof a coronavirus nite as fant of a LAST sr dose ot he

Ä ; ha 2 : SEER) mar + ANS SU 3 hvlaotic tresiment icentrstion ner da 3Ä ; ha 2 : SEER) mar + ANS SU 3 hvlaotic tresiment icentrstion ner da 3

EEE bsolute concentration N hiv at leasEEE bsolute concentration N hiv at leases

LONI t an ahsolule cones: bh at tousLONI t an ahsolule cones: bra at tous

PAIRS ‘ i at an absolute : refarabiv at leas i iniatarad at an abs Baal preferably at © (ea inter eu nak CRY Samer set j etera \PAIRS ' i at an absolute : refarabiv at leas i iniatarad at an abs Baal preferably at © (ea inter eu nak CRY Samer set j etera \

De Sorniini ES € Co Mary © + PE sine sr II ONY Co sa cath iment May be admi oo ome fea atmiant hay à . + amt AN iG ang | or wasammsasm EE + x nt aeg 100 ug { I i si at at Her Pe 14 SS = SOMTAINNNGDe Sorniini ES € Co Mary © + PE sine sr II ONY Co sa cath iment May be admi oo ome fea atmiant hay à . + amt AN iG ang | or wasammsasm EE + x nt aeg 100 ug { I i si at at Her Pe 14 SS = SOMTAINNNG

Ad SRA or SEE EN À tt = ua ue . Fy + SamngAd SRA or SEE EN À tt = ua ue . Fy + Samng

SOS ug, Le, conta 4 fviinictrationm UGSS; C at least 840 ua, La, C ee. administration à 2 tion of at east 500 MG, sition (Le admin entration of at leastSOS ug, Le, conta 4 fviinictrationm UGSS; C at least 840 ua, La, C ee. administration à 2 tion of at east 500 MG, location (Le admin entration of at least

COMPOSNIAN (LS, € bsoiute concentration of te,COMPOSNIAN (LS, € bsoiute concentration of te,

COMpO biy at an absolute cong A titan = Bahr Sr SAY AL | | nn , s arte x Rs nrotarat NY AR Da oo as cations Lrafaram ç sa te 200 uCOMPO biy at an absolute cong A titan = Bahr Sr SAY AL | | nn , s arte x Rs nrotarat NY AR Da oo as cations Lrafaram ç sa te 200 u

Higmatively pra 3 . bly from 300 to 1Higmatively pra 3 . bly from 300 to 1

DAT 214 TRY LAN OS nn ne a.DAT 214 TRY LAN OS nn ne a.

EO pay CS I T 2 sreforabty fom aEO pay CS I T 2 sreforabty fom a

SAG UG, &) CYNE boven orate SNA ooSAY UG, &) CYNE boven orate SNA oo

WARE ANY a 4 NN RARE Mit 4 x x aniagegus ifGOODS ANY a 4 NN RARE With 4 x x aniagegus if

S TON tn 17 SG MASSE N Le ea advaniags y of 200 to 1,200 BM} is is particularly advants 3 tin the range of 700 to 1, Heci, This is particularly à Tanned Tim VIE Ta De subie TEST 1TUS IS pS TON tn 17 SG MASSE N Le ea advaniags y of 200 to 1,200 BM} is is particularly advants 3 tin the range of 700 to 1, Heci, This is particularly à Tanned Tim VIE Ta De subie TEST 1TUS IS p

Ar Si EST IN tie X . therapeutic effect. 7 NIAr Si EST IN tie X . therapeutic effect. 7 NI

N ail EAS iies the they SACLE Sir bre-disease, a ; inte TSNIES IE Qi: ISSN Since prises FEAST LATE x Ran sa FER N othar nr ; dat intenses kenad by othe { hic araaths RNG ; : WESRKSENS DY > ase Co i ireseiiv WEHKSNS J farrad. as this U > ted is already wes ; * retarre x sam ki <> a beat ad on ss IC RPGR prafarrad, biect to be treated is alread NI y à the sudiec! to he tre iissase, hvnerian: ; fF fe Susi t a Nas fase TIEN ail EAS iies the they SACLE Sir bre-disease, a ; inte TSNIES IE Qi: ISSN Since prizes FEAST LATE x Ran sa FER N othar nr ; dat intenses kenad by othe { hic araaths RNG ; : WESRKSENS DY > ase Co i ireseiiv WEHKSNS J farrad. as this U > ted is already wes ; * retarre x sam ki <> a beat ad on ss IC RPGR prafarrad, biect to be treated is alread NI y à the sudiec! to he tre iissase, hvnerian: ; fF fe Susi t a Nas fase TIE

OA IN TV OT tie TES + FOV EN HIssase ; vi cs systoir Xi AIN + Honulmonas y Ais ç immune system © ii cardiopuimoana 3 fan WNITIUNS >, La tie CSTOIODU! | =OA IN TV OT tie TES + FOV EN HIssase ; vi cs systoir Xi AIN + Honulmonas y Ais ç immune system © ii cardiopuimoana 3 fan WNITIUNS >, La tie CSTOIODU! | =

TH WEIN ILY x a MSN AT $ oo oo fiahatas. chronic vmnhoma ofTH WINE ILY x a MSN AT $ oo oo fiahatas. chronic vmnhoma of

X Sian Se Sat ke x RN Kery whomaX Sian Se Sat ke x RN Kery whoma

Nonnen LEEDS, Sen + no far disease, dis any malionanc ; IYI . Serie HAWS, INSU anu © SONS yNuns LEEDS, Sen + no far disease, dis any malionanc ; IYI. Series HAWS, INSU anu © SONS y

Hovasoular diss MODSHIV, anv ms 3 a HIOVASCIHEN SHEN HAT ¥ 3 .Hovasoular diss MODSHIV, anv ms 3 a HIOVASCIHEN SHEN HAT ¥ 3 .

Co {i VRE Ph y + . +Co {i VRE Ph y + . +

SG, Cargiove PN OISSASE€, AILS : ut anaSG, Cargiove PN OISSASE€, AILS : ut ana

Ge it pulmonary WIDER, if the subiast already - ROUE si SENSE Cn io i; 13e SHrOHS Duly 3 root or he cc disease, chronic Ë erat qu x SANS cat ed “ tement § rent ; ic renal disease, (rsaiment thes , hernie PEN! gis Co sretrsatment à a nn States HEN A HEN SaaleGe it pulmonary WIDER, if the subiast already - ROUE si SENSE Cn io i; 13e SHrOHS Duly 3 root or he cc disease, chronic Ë erat qu x SANS cat ed “ tement § rent ; ic renal disease, (rsaiment thes , hernia PEN! gis Co sretrsatment à a nn States HEN A HEN Saale

Lynda SSONISISSd prays neantrationLynda SSONISISSd prays neantration

Red iE hy es SHIREY | ToL concentration : SSIDIY associsi X Po iba : oncentra 3 DOSSIDIV 2880 Co ee ; cr SGOSSIDIV ad absolute © 4 HEY ANG DOSSIN ¥ ood absolu or vire TLRTION SSII ON an INOrSaSed ahsRed iE hy es SHIREY | ToL concentration: SSIDIY associsi cr SGOSSIDIV ad absolute © 4 HEY ANG DOSSIN ¥ ood absolu or vire TLRTION SSII ON an INOrSaSed ahs

Fondant SCHEN ANGER ? os adeno an noraas a A “diva of tha APE, ANH influence ofFondant SCHEN ANGER? os adeno an noraas a “diva of tha APE, ANH influence of

SEE Irresnective of the ai she influence of 2 2 Since HTESDECTVE mn en tection IFES ES an > IY LAE Nua * - hs STITT est } COTONA HITOCHOIN, tapé sardines à murimiz ! roms ce ES Ps chaise ay EEE suffers from a core X as this substantialhSEE Irresnective of the ai she influence of 2 2 Since HTESDECTVE mn en tection IFES ES an > IY LAE Nua * - hs STITT est } COTONA HITOCHOIN, tapé sardines à murimiz ! roms ce ES Ps chaise ay EEE suffers from a core X as this substantialh

Co Tea Ea SID ANS SLCo Tea Ea SID ANS SL

N fan nraferran QD i is also HOTRITeQ, 1 peptide Is also prets tiger Ste hale tueN fan nraferran QD i is also HOTRITeQ, 1 peptide is also prets tiger Ste hale tue

Hi À, anugen AGRI per 3 SA dt "3 = = per Mi ; tartine ische PalentanmaldungHi À, anugen AGRI per 3 SA dt "3 = = per Wed ; tartinean palentan announcement

Liuxemburaische PateLiuxemburaian godfather

Luxemburg a SATA 28.02 2023Luxembourg to SATA 28.02 2023

CE ai id ,CE ai id ,

MAAS rasMAAS ras

FMCR GmbH nFMCR GmbH n

SoD LIENSoD LIEN

MO-0005-P-LU()MO-0005-P-LU()

PRIC-GCOS-P-LU(ZIPRIC-GCOS-P-LU(ZI

Pela rd u: . Ch oa ee od ead SF fhe L a En Ey x 5 x i are) a + 3 Aarhminigtratian tm tha : A i 2) after {hair administration ta + ¢ i ic { 3 by Hgases) a INS agminisiraugn to INSPelard u: . Ch oa ee od ead SF fhe L a En Ey x 5 x i are) a + 3 Aarhminigtratian tm tha : A i 2) after {hair administration ta + ¢ i ic { 3 by Hgases) a INS agminisiraugn to INS

S Satin Fhe Hi À antinan DE glides iS 4 Oy HQases) WIT ANID alana ENS LE aus degradation of th LS ATUL ONE Sole MY Bg ; degradation WANS RG ERTL ; ; \ 3 = = =S Satin Fhe Hi À antinan DE glides iS 4 Oy HQases) WIT ANID alana ENS LE from degradation of the LS ATUL ONE Sole MY Bg ; degradation WANS RG ERTL ; ; \ 3 = = =

SsSs

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PMG N od H x 2 A0 pa in feet Ÿ ais ELEY its gy oh. 28.92 7023 Luxemburgische PalentanmeldungPMG N od H x 2 A0 pa in feet Ÿ ais ELEY its gy oh. 28.92 7023 Luxembourg palental registration

MCL -P-LU(Z) £0.02 EVE LUXE TD UT CHSCT :MCL -P-LU(Z) £0.02 EVE LUXE TD UT CHSCT :

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FORO AR activating peptides can De heuristically designed, Subsequentiy, Screening with high-resolution analysis of antibodies induced by the vaccines Is required to determine both neutralization capacity and epifope specificity.FORO AR activating peptides can De heuristically designed, Subsequentiy, Screening with high-resolution analysis of antibodies induced by the vaccines Is required to determine both neutralization capacity and epifope specificity.

In an alternative embodiment of the present invention, the amino acid sequences of the HLA antigen peptides of the SARE-CoV-Z corresponding fo the MHC complaxes (nonamers) with from the dataset! of the SARS-COV-2 virus proteins (nucleoprotein, UNIPROT Reference ID relation with other human coronaviruses and non-variant mudations were selected from proteins with a combination of different bioinformatic methods to further analyze. To this scope, the Nucieccapsid protein was aligned agsinst 5 coronaviruses with COBALT too! (Human respiratory Syndrome coronavirus 2, UNIPROT reference: Q883E1} according to a conservation algorithm based on the relative entropy threshold of the residue, SARE CoV-ZIn an alternative embodiment of the present invention, the amino acid sequences of the HLA antigen peptides of the SARE-CoV-Z corresponding to the MHC complaxes (nonamers) with from the dataset! of the SARS-COV-2 virus proteins (nucleoprotein, UNIPROT Reference ID relation with other human coronaviruses and non-variant mudations were selected from proteins with a combination of different bioinformatic methods to further analyze. To this scope, the Nucieccapsid protein was aligned agsinst 5 coronaviruses with COBALT too! (Human respiratory Syndrome coronavirus 2, UNIPROT reference: Q883E1} according to a conservation algorithm based on the relative entropy threshold of the residue, SARE CoV-Z

UNIPROT reference: PTS425) Human coronavirus OCéS, UNIPROT reference: P3834, cororavirus, UNIPROT reference: PRESSES; Human Coronavirus NLS, UNIPROT reference: peptide is presented In vivo on the corresponding MHC complexes of the SARS-COV-2 virus with the highest conservalsd character have a laser probability of mulations across nowUNIPROT reference: PTS425) Human coronavirus OCéS, UNIPROT reference: P3834, cororavirus, UNIPROT reference: PRESSES; Human Coronavirus NLS, UNIPROT reference: peptide is presented In vivo on the corresponding MHC complexes of the SARS-COV-2 virus with the highest conserved character have a laser probability of mululations across now

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PMCR GmbHPMCR GmbH

PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung a0 23PRIC-GCOS-P-LU(ZI 28.02 2023 Luxembourg Palentan declaration a0 23

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PRMOR GmbHPRMOR GmbH

PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung circumventing existing immunization efforts, for example from prior infections or immunization against a other strain of the virus,PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung circumventing existing immunization efforts, for example from prior infections or immunization against another strain of the virus,

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PMOR GmbHPMOR GmbH

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CH 2202 7593 Lukemburgische PatantanmaidungCH 2202 7593 Lukemburg Patantanmaidung

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DAAMLONOSLDLE LID 20.032 EUDAAMLONOSLADLE LID 20.032 EU

SAND HSL sequences of the conserved viral epitope, preferably a coronavirus, more preferably a halgoorongvivus, especially preferably a sarbecovitus, most preferghly 8 SARS-Cov-2 epitope, in particular most preferably the conserved regions of the spike protein and nucleocapsid determined as nt D), can be aligned using à suitable tool or algorithm, Any means performed using at least two, praforably three, and Most preferably four of ihe above programs beiween the different methods, In a preferred embodiment of the present invention, the the ML model in matehing à nentide fo the anilong), In an even more nreferred ambodimengtSAND HSL sequences of the conserved viral epitope, preferably a coronavirus, more preferably a halgoorongvivus, especially preferably a sarbecovitus, most preferably 8 SARS-Cov-2 epitope, in particular most preferably the conserved regions of the spike protein and nucleocapsid determined as nt D ), can be aligned using à suitable tool or algorithm, Any means performed using at least two, preferably three, and Most preferably four of the above programs according to the different methods, In a preferred embodiment of the present invention, the ML model in matehing à nentide fo the anilong), In an even more nreferred ambodimengt

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In à especially preferred embodiment of the current invention, when a combination of the above ool is used in à combination polypeptide, a better In vivo docking response can be achiavedIn à especially preferred embodiment of the current invention, when a combination of the above ool is used in à combination polypeptide, a better in vivo docking response can be achieved

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More preferably with more than 75% and most preferably with more than 80% by other sequence rapstiion and the method score result for the epitope prédiction, which is ater used in an altemathve ambadimant of the prasent invention, the B-cell binding pradiclion Is dong with the entire amino acid sequence of the virus epitops without the preselection of the conserved regions between different virus regions as described in step bi The results are than comparedMore preferably with more than 75% and most preferably with more than 80% by other sequence rapstiion and the method score result for the epitope prediction, which is ater used in an altermathve ambadimant of the present invention, the B-cell binding pradiclion Is dong with the entire amino acid sequence of the virus epitopes without the preselection of the conserved regions between different virus regions as described in step bi The results are than compared

PMCR GmbHPMCR GmbH

PMC-0COS-P-LU(Z) 28.02 2023 Luxemburgische Palentanmeldung xx ssPMC-0COS-P-LU(Z) 28.02.2023 Luxembourg Palent Declaration xx ss

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CT | D'OISTEDIV INS CONSO! Pa NS )CT | D'OISTEDIV INS CONSO! Pa NS )

HOST DIOIGTAIN 5: | | eeHOST DIOIGTAIN 5: | | ee

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MASK FTD NSS are obtained. Fraferabiv The INVES \INCQVIT GL NERS, U = = » SS i oa ae 4 WE CD ESA, LES LS DEN \ cias Si CO! \piexes arg odiained. rretorag y» N ;MASK FTD NSS are obtained. Fraferabiv The INVES \INCQVIT GL NERS, U = = » SS i oa ae 4 WE CD ESA, LES LS DEN \ cias Si CO! \piexes arg odiained. rretorag y» N ;

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WINES O AAG TAILLE VUEWINES O AAG TAILLE VIEW

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SHEN | IVITIDIIGOVESS (ti J / ©SHEN | IVITIDIIGOVESS (ti J / ©

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A ‘ aed la nrntain e VER + of nrafara ; fée Sram the whois nr Hi SEQUence Dre a sdlatinna) Kram the ANNE D'OTSIT iA’ aed la nrntain e VER + of nrafara ; fée Sram the whois nr Hi SEQUENCE Dre a sdlatinna) Kram the ANNE D'OTSIT i

Naow atta { Anus nandatinn BONES Waa ? = 3 Hadas furarichiasds nanul in nm. Froi ie s 1 atlaia {aresy Mids DODUIS }Naow atta { Anus nandatinn BONES Waa ? = 3 Hadas furarichiasds nanul in nm. Froi ie s 1 atlaia {aresy Mids DODUIS }

GIASS N SHOES LV LE IRAN X 3 SN XGIASS N SHOES LV LE IRAN X 3 SN X

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FRAG 5 GUL AV ED Luxemburgisohe f arenianimeaiqungQUESTION 5 GUL AV ED Luxemburgisohe farenianimeaiquung

NY 28.02 20° LUKSIMOUWIGISGNY 28.02 20° LUKSIMOUWIGISG

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DAAMLANASLDLE LEONDAAMLANASLDLE LEON

PMC-0G0S-1 LUE xPMC-0G0S-1 LUE x

SESE

SHI x +5 & m RALIMNSHI x +5 & m RALIMN

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Sisss i COMDISNXES re OSTEN, Ï SEES, ANSisss i COMDISNXES re EAST, Ï SEES, AN

Lalo 1 AAT IISA - ;Lalo 1 AAT IISA - ;

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OST proferabiv equal to 10 or ess and Tor a st La >OST proferabiv equal to 10 or ess and Tor a st La >

MOOS prataranly SIGNE WS IN A = ti non the virus anfans oanMOOS prataranly SIGNE WS IN A = ti non the virus anfans oan

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DE DIGIGNOSISS to Cover More Mil 8 :DE DIGIGNOSISS to Cover More Mil 8 :

ETE [PT Tin re vend oy ta ; sav” atisn thrauah a € at ; nibaïls human noanuiation th auah a broad coverage af ine HEN DET MRIS LIAS in order to ansure 8 broad LOWRIE OF INS munis gone i Order 10 STSUIS à Broad Cove NMETE [PT Tin re vend oy ta ; sav” atisn thruah a € at ; nibaïls human noanuiation th auah a broad coverage af ine HEN DET MRIS LIAS in order to ensure 8 broad LOWRIE OF INS munis gone i Order 10 STSUIS à Broad Cove NM

RE | ï si aad Sin anRE | ï si aad Sin an

Lady grat ciation u dhaLady grat ciation u dha

DE Foodie arte han nan into SATIN NS i 5 Ter at iaast QE OF INS WONIQWIGE PUS LIGHT WALLEY OLIS ee LR SR Fea > at WG ue A Ken Rates Ta SRE RSR = Fr ; i MT COYVSTage AiINHNO TOF A Safi VD broader HT COVETaG®, Qimy IX} IE 8 graaaer mL coverage, UDE Foodie arte han nan into SATIN NS i 5 Ter at iaast QE OF INS WONIQWIGE PUS LIGHT WALLEY OLIS ee LR SR Fea > at WG ue A Ken Rates Ta SRE RSR = Fr ; i MT COYVSTage AiINHNO TOF A Safi VD broader HT COVETaG®, Qimy IX} IE 8 graaaer mL coverage, U

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SANT SET AAT INN TRIS SY NY SIN RERO RTL ILES ny 3 = ASANT SET AAT INN TRIS SY NY SIN RERO RTL ILES ny 3 = A

COMDINETION IENOSNT SANCOMDINETION IENOSNT SAN

Fit FOLIE oe ana i: $3 pe sradictinn of MTL snttiane i {of the present invention, prediction of HTL apliops £ oy md AE eel iy a nd ot Ths orassnt HYVOITTIONT, DTOCICTON 8 4Fit FOLIE oe ana i: $3 pe sradictinn of MTL snttiane i {of the present invention, prediction of HTL apliops £ oy md AE eel iy a nd ot Ths orassnt HYVOITTIONT, DTOCICTON 8 4

Hoularly preferred ambodiment of the nresent inves ) ï i | npartiouiaiiy oratarrad ampagimeamn of Ih {Hoularly preferred ambodiment of the nresent investments ) ï i | npartiouiaiiy oratarrad ampagimeamn of Ih {

HT à DAriiCUIATIV oraraivsd OMDOONNE XHT à DAriiCUIATIV oraraivsd OMDOONNE X

Ne pa RÉ PRES = Ù at A A mal enitrnne match , Why NAS HAn af Dean a 3ne mated = va 1 Farman in naratiat with D'ESiCHON OT gain SHRGPE THIS i } OT, epitone match is performed in parallel with MELINA > match ang Aw EL sphiope FURAN AD FOI TAN ENG ÏNe pa RÉ PRES = Ù at A A mal enitrnne match , Why NAS HAn af Dean a 3ne mated = va 1 Farman in naratiat with D'ESiCHON OT gain SHRGPE THIS i } OT, epitone match is performed in parallel with MELINA > match ang Aw EL sphiope FURAN AD FOI TAN ENG Ï

De AN A wf ha Sa EN 3 NES AN ÿ (ANSaNneuE (TEN and a final à RENE n {TL and CTL), and conssnsus di TEL He À nna ; (OTL NetMHOCpan HTH oH Le N AAN ESSEN x 3 i NethHC (CTL), Net Dan (IL ang Li Ay SRDe AN A wf ha Sa EN 3 NES AN ÿ (ANSaNneuE (TEN and a final à RENE n {TL and CTL), and conssnsus di TEL He À nna ; (OTL NetMHOCpan HTH oH Le N AAN ESSEN x 3 i NethHC (CTL ), Net Dan (IL ang Li Ay SR

USING NetMHO Lhe PALE, INR NMR \ JUSING NetMHO Lhe PALE, INR NMR\J

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CB fi hi highly conserved TSGIGHS ard USSG TOT DTSOICTIC iy ; $ cire RARE Ivan Hraterably NECN LAM IRS VILA à Sia SS 3CB fi hi highly conserved TSGIGHS ard USSG TOT DTSOICTIC iy ; $ cire RARE Ivan Hraterably NECN LAM IRS VILA à Sia SS 3

COMDANSHT STAN SINT [VIS SUTIN, TES SAME S$COMDANSHT STAN SINT [VIS SUTIN, TES SAME S$

Lompansan neg SIL ITIL PET | © nn 3 Bash red Fm Tamas yr ASIN ande 3 Hons if the inclusion of a longer amino acid oe Naratahs conserved ragions Hine inclusion ot a ionge! à x ha avtansdast a manne eratehs conserved re HONS HOTTE but can De exiendec to VUS GRO LNG \Lompansan neg SIL ITIL PET | © nn 3 Bash red Fm Tamas yr ASIN ande 3 Hons if the inclusion of a longer amino acid oe Naratahs conserved ragions Hine inclusion ot a ionge! à x ha avtansdast a manne eratehs conserved re HONS HOTTE but can De exiendec to VUS GRO LNG \

ALE Lait VO WALT ooALE LAIT VO WALT oo

LATE an ntinvstas are x 1 : S een STI asia €: SNSIQRIESS areLATE an ntinvstas are x 1 : S een STI asia €: SNSIQRIESS are

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LU103078 pradicglion aigorthms, preferably AlerTOPR, and/or AtergentP, The in a more retested not allergenic if the Tanimoto index is preferably below 0.8, more preferably below 0.7. § in an sspecially preferred embodiment of the current vention, the physicochemical properties of the amino acid sequences from a-0) are determined, The solubility of the peptides is determined using à program such as Soro, which can be run with any length of amino acid, the toxicity potential is determined using a program such as ToxinFred, and other skilled in the art, Inthe case of epitopes, His important fo consider the molecular weight, length, 3 X nN EEN EN EE TN ET EAL re WA A WE et WA polar epitopes al SUBOUIANGOUS pH (5-6) 15 avoid precipitation and preferences for hydy ephobic : © AR as is pis See evesiedie 16 SUbCLiaNñeous environment while avoiding the formation of salts in the slightly acidic environment, &) in one embodiment of the current invention, artificial tandem polypeplides are creatso (ML) approach to predict the immunogenicity and verifying the results with in vivo feedback, In immunogenicity studies such as slispat and ELISA The immunogenic epitopes predicted based on an in-house ML model, since the binding affinity determined in accordance with the current invention as specified in the previous step D) is not accurate enough in dself to predict whether a polypeptide of the invention is immunogenic or notLU103078 pradicglion aigorthms, preferably AlerTOPR, and/or AtergentP, The in a more retested not allergenic if the Tanimoto index is preferably below 0.8, more preferably below 0.7. § in a specially preferred embodiment of the current vention, the physicochemical properties of the amino acid sequences from a-0) are determined, The solubility of the peptides is determined using à program such as Soro, which can be run with any length of amino acid, the toxicity potential is determined using a program such as ToxinFred, and other skilled in the art, In the case of epitopes, His important fo consider the molecular weight, length, 3 X nN EEN EN EE TN ET EAL re WA A WE et WA polar epitopes al SUBOUIANGOUS pH (5-6) 15 avoid precipitation and preferences for hydy ephobic : © AR as is pis See evesiedie 16 SUbCLiaNñeous environment while avoiding the formation of salts in the slightly acidic environment, &) in one embodiment of the current invention, artificial tandem polypeplides are creatso (ML) approach to predict the immunogenicity and verifying the results with in vivo feedback, In immunogenicity studies such as slispat and ELISA The immunogenic epitopes predicted based on an in-house ML model, since the binding affinity determined in accordance with the current invention as specified in the previous step D) is not accurate enough in itself to predict whether a polypeptide of the invention is immunogenic or not

In one embodiment of the current invention, the prediction of the immunogenicity of an antigen polypeptide matching a viral epitope was done using an SVM-Dased model which was trained trained ML model in aecordance with the currant invention preferably has an accuracy of aiIn one embodiment of the current invention, the prediction of the immunogenicity of an antigen polypeptide matching a viral epitope was done using an SVM-Dased model which was trained ML model in accordance with the current invention preferably has an accuracy of AI

PG oon. 28.02 2023 Luxemburgische PalentanmeldungPG oon. 28.02 2023 Luxembourg Palent Application

PMC-0005-P-LU(2) 28.02 2023 Luxemburgis qPMC-0005-P-LU(2) 28.02 2023 Luxembourgis q

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LU103078 considers the physicochemical properties of the polypeplides such as hydrophobicity, pl, charge, molecular weight molecular weight, which are important for the synthesis of these peptides, For polypeptides, N is important to consider the molecular weight, pl and charge at hydrophobic peptides {positive GRAVY results), This has the technical effect of beter simudating in vivo conditions and therefore more appropriate antigen peptide selection compared to binding affinity predictions alone, resulng In better immunization and shorter in a particularly preferred embodiment, calculated values related fo an antigen polypeptide are considered for the ML model training, such as immunogenicity, using means known to a person skilsd In the arts, for example EDR the TAP proteosams using a program such asLU103078 considers the physicochemical properties of the polypeptides such as hydrophobicity, pl, charge, molecular weight molecular weight, which are important for the synthesis of these peptides, For polypeptides, N is important to consider the molecular weight, pl and charge at hydrophobic peptides { positive GRAVY results), This has the technical effect of better simudating in vivo conditions and therefore more appropriate antigen peptide selection compared to binding affinity predictions alone, resulting in better immunization and shorter in a particularly preferred embodiment, calculated values related fo an antigen polypeptide are considered for the ML model training, such as immunogenicity, using means known to a person skilsd In the arts, for example EDR the TAP proteosams using a program such as

Nat TlLnan and the cleavage sles using a araaram such as NaetChonNat TlLnan and the cleavage sles using an araaram such as NaetChon

NOT LDAN, EN Ne GCIOAVAGS Sred USING à progrant, SUCH ad Netunap. in one ambodimend of the current invention, the trained ML model corraigtion data beiween nats and outputs can he guantifiad ang is oabhtainagd in aranartans of Nin iii Tharafora HisNOT LDAN, EN Ne GCIOAVAGS Sred USING à progrant, SUCH ad Netunap. in one ambodimend of the current invention, the trained ML model corraigtion data beiween nats and outputs can he guantifiad ang is oabhtainagd in aranartans of Nin iii Tharafora His

HIRAI aH VLAÇNES Lal) VE QUOATIISION QE 19 DLO BE TATE VI UW A HH PSS GI MIS possible io quantify the parameters which are particularly influential in the poiypeptids selsction thus allowing for further sten by stan improveamant of the dataHIRAI aH VLAÇNES Lal) VE QUOATIISION QE 19 DLO BE TATE VI UW A HH PSS GI MIS possible io quantify the parameters which are particularly influential in the poiypeptids selsction thus allowing for further sten by stan improveamant of the data

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One example of such a trained ML model and the correlation between input and output dala by it in this particular embodiment of {he current invention, the BA-rank result from it is therefore an ouisianding schisvement of ths inventors to have found that additional factors can be considered using machine learning (ML to predict immunogenicity in silico. The antigen polypeplides determined in the previous steps must De processed in the organism and this approach resembles much More In vivo conditions, where chemistry, such as protonation reactions, precipitations, cleavage of the peptides occur, and thus pure binding affinityOne example of such a trained ML model and the correlation between input and output dala by it in this particular embodiment of {he current invention, the BA-rank result from it is therefore an ouisianding schisvement of ths inventors to have found that additional factors can be considered using machine learning (ML to predict immunogenicity in silico. The antigen polypeplides determined in the previous steps must be processed in the organism and this approach resembles much more in vivo conditions, where chemistry, such as protonation reactions, precipitations, cleavage of the peptides occur, and thus pure binding affinity

Deller, safer, and quicker candidate selection and the feedback von vivo studies can directlyDeller, safer, and quicker candidate selection and the feedback from vivo studies can directly

PMCR GmbHPMCR GmbH

PMC-G005-P-LU(Z) 28.02 2023 Luxemburgische PalentanmeldungPMC-G005-P-LU(Z) 28.02.2023 Luxembourg Pallet Registration

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EAC Saad iEAC Saad i

FMOR GmbHFMOR GmbH

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SAND HSL EAN LUXSIMOUTUISCHE Faenianimaiqung virus while avoiding infection-enhancing antibodies. Any amino acid sequences with allergenichy or antigenicity concems, as wall as unsulled physicochemical properties, such as physiclogical pH combabiiity or toxicological properties, In peptides the instability, aliphatic low weight in the overall optimization, This discovery by the inventors allows a broader range of polypeptides to be considered than is the case with previous, conventional methods, in some embodiments of the current Invention, the following thresholds have been introduced proteome afianment and toxicity, The use of such cutoff points represents a disc bySAND HSL EAN LUXSIMOUTUISCHE Faenianimaiqung virus while avoiding infection-enhancing antibodies. Any amino acid sequences with allergenicy or antigenicity concerns, as wall as unsullied physicochemical properties, such as physiclogical pH combabiiity or toxicological properties, In peptides the instability, aliphatic low weight in the overall optimization, This discovery by the inventors allows a broader range of polypeptides to be considered as is the case with previous, conventional methods, in some embodiments of the current Invention, the following thresholds have been introduced proteome afianment and toxicity, The use of such cutoff points represents a disc by

I Proteome aignmeant and (OXICHy. ERS USE OT SUCH CUTOT DOIMS rept ssents a CSCOVETY by INS inventors that has the technical effect of significantly improving the ML model used and each valua is a discovery of is own by the inventors, The following cutoff points significantly improve the model training and are the result of a difficull optimization process. in one embodiment of the current invention, amino acid sequences where excluded which had antigenic predictions with a value below 0.8, more preferred below 05, most preferred below than 30% and most preferred more tam 35% fo human proteome. Preferaniy, non-soluble ware also excluded, in a nrefarred ambadimant of the invention. any such amino acid sed { 20 HY à DrSTSIred SMDooNTEnt OF The Manion, ONIV SUCH aming adi SSQUSNCES IN SCCOIDANCE includedI Proteome aignmeant and (OXICHy. ERS USE OT SUCH CUTOT DOIMS rept ssents a CSCOVETY by INS inventors that has the technical effect of significantly improving the ML model used and each value is a discovery of is own by the inventors, The following cutoff points significantly improve the model training and are the result of a difficull optimization process. in one embodiment of the current invention, amino acid sequences where excluded which had antigenic predictions with a value below 0.8, more preferred below 05, most preferred below 30% and most preferred more tam 35% fo human proteome. Preferaniy, non-soluble ware also excluded, in a nrefarred ambadimant of the invention. any such amino acid sed { 20 HY à DrSTSIred SMDooNTEnt OF The Manion, ONIV SUCH aming adi SSQUSNCES IN SCCOIDANCE included

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NUWOCGUCEA OI ING PrGSSIGCUON of amine adidas TOT INS WSICHUNG, EXPHORNV ON anargenicny, solubility, human proteome alignment and foxiciHy, Amino acid sequences where excluded which had antigenic pradiclions with a value below 0.4, toxic epitopes, peptides with higher similarity than 35% to human proteome and non-soluble peptides with a solubility value below 4.8 Only amino acid sequences with HTL matching below 5 and sequences matching alisles in the B-cell prediction Factor À, then the coverages results for MTL 5 factor 0.7) and numberNUWOCGUCEA OI ING PrGSSIGCUON of amine adidas TOT INS WSICHUNG, EXPHORNV ON anargenicny, solubility, human proteome alignment and foxiciHy, amino acid sequences where excluded which had antigenic pradiclions with a value below 0.4, toxic epitopes, peptides with higher similarity than 35% to human proteome and non-soluble peptides with a solubility value below 4.8 Only amino acid sequences with HTL matching below 5 and sequences matching alisles in the B-cell prediction Factor À, then the coverages results for MTL 5 factor 0.7) and number

PMOR GmbHPMOR GmbH

PMC-0005-P-LUD 28.02 2023 Luxemburgische PalentanmeldungPMC-0005-P-LUD 28.02.2023 Luxembourg Pallet Registration

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Occurring allelic variants of the peptide sequences.Occurring allelic variants of the peptide sequences.

In this context the nharmacautioal comnasition is orafarahiy annliad subeotanasoushy underIn this context the nharmacautioal comnasition is orafarahiy annliad subeotanasoushy under

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As further described herein, the amine acid sequences used in the vention are single variableAs further described, the amine acid sequences used in the vention are single variable

HLA antigen peplide domains C'HLAS or "HUA complex). A single variable MLA antigen peptide domain is (as further defined herein) a region within the amino acid sequence of a protein that can be distinguished from Hs surrourding sequence based on defined pharseptarietipeHLA antigen peplide domains C'HLAS or "HUA complex). A single variable MLA antigen peptide domain is (as further defined in) a region within the amino acid sequence of a protein that can be distinguished from Hs surrourding sequence based on defined pharseptarietipe

CHAT SGISTISUGS,CHAT GISTISUGS,

Amino acid SSQUENGES, OT regions within the amine acid sequence of 8 protein of ths invention, that are HLAS are also referred to herein as "HLA of the invention. ” Some preferred examplesAmino acid SSQUENGES, OT regions within the amine acid sequence of 8 protein of the invention, that are HLAS are also referred to as "HLA of the invention." Some preferred examples

IE ait FILAS SIE SiS TOITS SG ID NEO as MILAS OV NS vein. sume PVRS EXaTqies of single variable HLA antigen peptide domains suitable for use in the Invention are apparentIE ait FILAS SIE SiS TOITS SG ID NEO as MILAS OV NS vein. sume PVRS EXaTqies of single variable HLA antigen peptide domains suitable for use in the invention are apparent

The following terms are used to describe sequence relationships beiween two or more amino acid sequences or polypeptide sequences: “reference sequence,” ‘amino acid exchange,” inthe context of the present invention, the term "Coronavirus” is used preferabiy to describe a orthocoronavirinae, more praferably to describe betacoronaviruses, particularly preferably to describe à sarbecovirus, most preferably DARS-CoV- 2, especially a wildtype (WT) or mutant of ong aming acid for another amino acid within the amine acid sequence of the HLA antigen antigen peptide), "Sequence identity” “percentage of sequence identity,” or identity or similarity with respect to said amine acid sequence is defined herein as the percentage ofThe following terms are used to describe sequence relationships between two or more amino acid sequences or polypeptide sequences: “reference sequence,” 'amino acid exchange," in the context of the present invention, the term "Coronavirus" is used preferabiy to describe an orthocoronavirinae , more preferably to describe betacoronaviruses, particularly preferably to describe à sarbecovirus, most preferably DARS-CoV-2, especially a wildtype (WT) or mutant of ong amino acid for another amino acid within the amine acid sequence of the HLA antigen antigen peptide) , “Sequence identity” “percentage of sequence identity,” or identity or similarity with respect to said amine acid sequence is defined purely as the percentage of

PMOR GmbHPMOR GmbH

PMC-0COS-P-LU(Z) 28.02 2023 Luxemburgische Palentanmeldung residue) or similar (Le, amino acid residue from the sams group based on common side chain characteristics sas halow) to the amino soit sequence of tha wild tynePMC-0COS-P-LU(Z) 28.02 2023 Luxembourg Palent Application residue) or similar (Le, amino acid residue from the sams group based on common side chain characteristics sas halow) to the amino soit sequence of tha wild tyne

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According to a preferred embodiment of the present invention, the amino acid substitution for the HLA antigen peptide corresponding fo the class | and/or class H MHC complexes § comprises at least ons substitution at any position within the amine acid sequence relative toAccording to a preferred embodiment of the present invention, the amino acid substitution for the HLA antigen peptide corresponding fo the class | and/or class H MHC complexes § comprises at least ons substitution at any position within the amine acid sequence relative to

For the purpose of comparing wo or more amino acid sequences, the percentage of “sequence identity” beiween a first amino acid sequence and a second amino acid sequence sequence thal are identical to amino acids at corresponding postions in the second amino acid sequence, by [the total number of amino acids in the first amino acid sequence] and multioiying by [100%], wherein each deletion, insertion, substitution or addition of an amine considerad as a difference fo a single amine acid (position). disease is often construed as & medical condition associated with specific symptoms and infectious disease, or X may be caused by internal dysfunctions, such as autoimmune diseases. In humans, “disease” is often used mors broadiyio refer io any condition that Causes nroblames for those in contact with the individual In this broader sense. § sometimes includesFor the purpose of comparing where or more amino acid sequences, the percentage of “sequence identity” given a first amino acid sequence and a second amino acid sequence sequence are identical to amino acids at corresponding positions in the second amino acid sequence, by [ the total number of amino acids in the first amino acid sequence] and multiplication by [100%], wherein each deletion, insertion, substitution or addition of an amine is considered as a difference for a single amine acid (position). disease is often constructed as & medical condition associated with specific symptoms and infectious diseases, or X may be caused by internal dysfunctions, such as autoimmune diseases. In humans, “disease” is often used to refer to any condition that causes problems for those in contact with the individual in this broader sense. § sometimes includes

BARGAINS PAT ANION I Laie WALID LE IG TIM INSTE HEY LS AAI oN ies, ER SPESEN INGLIS and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories, Diseases usually affect individuals not only physically, but also emotionally, as contracting and living with many diseases can alter ones perspective on fife, and one’s personality.BARGAINS PAT ANION I Laie WALID LE IG TIM INSTE HEY LS AAI oN ies, ER SPESEN INGLIS and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories, Diseases usually affect individuals not only physically, but also emotionally, as contracting and living with many diseases can alter one's perspective on fife, and one's personality.

In the present context, the term "treatment" or Mrealing” relates to the management and cars of à subject or an individual for ihe purpose of combating a condition such as a disease or disorder, The term is intended to include the full spectrum of treatments for a given condition from which the subject is suffering, such as administration of the therapeutically effective disorder or condition, to alleviate or relief the symptoms and complications, and/or to cure or eliminate the disease, disorder or condition as well as fo prevent the condition, whereinIn the present context, the term “treatment” or Mrealing” relates to the management and cars of à subject or an individual for their purpose of combating a condition such as a disease or disorder, The term is intended to include the full spectrum of treatments for a given condition from which the subject is suffering, such as administration of the therapeutically effective disorder or condition, to alleviate or relieve the symptoms and complications, and/or to cure or eliminate the disease, disorder or condition as well as fo prevent the condition, wherein

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PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburaische PatentarmelduriePRIC-GCOS-P-LU(ZI 02/28/2023 Luxembourg patent armelduria

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Antigen ps SN {oe : NAT TIRES l'ÉREiN A SARSES ; usAntigen ps SN {oe: NAT TIRES l'ÉREiN A SARSES ; us

ERE Dean Pace re M | mame TRAY SN OT 1007 4585 | Chain À 8 spike ghyoaprote SreeERE Dean Pace re M | mame TRAY SN OT 1007 4585 | Chain À 8 spike ghyoaprote Sree

MA NTT HARE TES SOPTRL 1071, i ese a i ; ads | eA “0 . hin ; | Tm ion A RAE UE VD emilre slyconrotein { 8 (és SEQ D RDS pr i ACTE RE n À SARS-CoV-7 soie ah, ;MA NTT HARE TES SOPTRL 1071, i ese a i ; ads | eA “0 . there ; | Tm ion A RAE UE VD emilre slyconrotein { 8 (és SEQ D RDS pr i ACTE RE n À SARS-CoV-7 soie ah, ;

Anger peptide (SEQ 1D ne Lo + PEN U EER {Chain À BARS esAnger peptide (SEQ 1D ne Lo + PEN U EER {Chain À BARS es

Lo | . BAN MRR CET Wes Sur T1 EE oO hain À, ycoprotel m ooLo | . BAN MRR CET Wes Sur T1 EE oO hain À, ycoprotel m oo

Han ee TERRA I RIFRKSNER | 5,88 EC CEE NT akHan ee TERRA I RIFRKSNER | 5.88 EC CEE NT ac

RRS 8 ; ; ANOS | ee A Halte TROT ETES pa av =; soike a fyoopt otsin (4 i 3 peptide (SEC io 1G8 ! XGA | x PT EL : = = = SES Ca STRRS 8 ; ; ANOS | ee A Hold TROT ETES pa av =; soike a fyoopt otsin (4 i 3 peptide (SEC io 1G8 ! XGA | x PT EL : = = = SES Ca ST

HR | PPT SE A | tT x Et ON A &; {Okan : ,Ç lycoprot ss 2 CE > Same No « Slay on Pens 37 pike gi iHR | PPT SE A | tT x Et ON A &; {Okan: ,Ç lycoprot ss 2 CE > Same No « Slay on Pens 37 pike gi i

ER inter = RRS AY POV YRS F 12887 i THOM PM ETER inter = RRS AY POV YRS F 12887 i THOM PM ET

IE : OUT WC SON TT nn AT She 4 ax, | one [HAAR TE : opr S-GoV75 spike giveoprotein {IE : OUT WC SON TT nn AT She 4 ax, | one [HAAR TE: opr S-GoV75 spike giveoprotein {

AAA ED | UTVELFSRSNI Trans l Chain À SARSAAA ED | UTVELFSRSNI Trans l Chain À SARS

Ml 5 {SEC ID NO 8 | HLA-B27TOS FP YRLFT ; ae ra oe ie + { {1 82 i aMl 5 {SEC ID NO 8 | HLA-B27TOS FP YRLFT ; ae ra oe ie + { {1 82 i a

CHAE AE fide (SEQ ID NOE) | Ho | eT ù ; © ° ger 8 pee © oe © ; i x : : 3 17 , i ; EE _ - | = ; = 1CHAE AE fide (SEQ ID NOE) | Ho | eT ù ; © ° ger 8 pee © oe © ; i x : : 3 17 , i ; EE _ - | = ; = 1

Le | aaa j FT TRENT Ke Siycoprotein (457-521) _ ee EEE UA RE ain À, SARS-CoV-2 spike given a : RVVVLSF 11 5238 FACE Mat EL, GRAS en PALe | aaa j FT TRENT Ke Siycoprotein (457-521) _ ee EEE UA RE ain À, SARS-CoV-2 spike given a: RVVVLSF 11 5238 FACE Mat EL, GRAS en PA

ST pv AAT GE YS DE 5] 116 ; RE LYON) Ba.ST pv AAT GE YS DE 5] 116 ; RE LYON) Ba.

THAR SE | PYRVVVLSF LE i AAR Le SES ATHAR SE | PYRVVVLSF LE i AAR Le SES A

NOH 1 re nn ro } t KU KU RK RY spike givconroteir (497 + x ie (SEO D NO LT berger A BARS EEE Spike givootNOH 1 re nn ro } t KU KU RK RY spike givconroteir (497 + x ie (SEO D NO LT berger A BARS EEE Spike givoot

AR Antigen pats Ee oo sr brand wa P'ohain À SARS-Coy j ; : Prison PES ne PUTENEETITI ve BY RL Hd 9 44 oe _ ha : - STE Tu mare ; ; HOY IR 21 ;AR Antigen pats Ee oo sr brand wa P'ohain À SARS-Coy j ; : Prison PES ne PUTENEETITI ve BY RL Hd 9 44 oe _ ha : - STE Tu mare ; ; HOY IR 21 ;

Ha “SES ID NOCTO! | HLA-B3SOY YO 2 ; vert tes tad CIS ID Nr "qu N HI es i i :Ha “SES ID NOCTO! | HLA-B3SOY YO 2 ; vert tes tad CIS ID Nr "qu N HI es i i :

HA ieee EERE en i 1431,09 i SS eeeHA ieee EERE en i 1431.09 i SS eee

I. _ Mi © j ; i Ninn i A ATI KENN mr ke alveaprotein (397 > . SAA Pan Chain À, SARS-CoV-2 spike alyoor 2 ; AOL SEEL 17 GOs thus SY AA, SEAT > A 8 ' SEN AVLSFEI : 250 5 | LESE 3 NAN os = =I. _ Wed © j ; i Ninn i A ATI KENN mr ke alveaprotein (397 > . SAA Pan Chain À, SARS-CoV-2 spike alyoor 2 ; AOL SEEL 17 GOs thus SY AA, SEAT > A 8 ' SEN AVLSFEI : 250 5 | READ 3 NAN os = =

J een Poe SOS ANT ES RAILS orem roteïn (902-918) pro LE : = | rs È re A TERS Da TS spike giyconrotein { 3 pestis (SEQ TDNG 11 Loin brea Ain A ERSTE spike ies iJ een Poe SOS ANT ES RAILS orem roteïn (902-918) per LE : = | rs È re A TERS Da TS spike giyconrotein { 3 pestis (SEQ TDNG 11 Loin brea Ain A FIRST spike ies i

TINEA pepe OF = SN ; metier EEE e een ow ARE AY i Shai À \ SAR siycoprotein (80: ae ; : : enr Peace EER i = 37 Sy 3 | 435 03 >Cov-2 spikeTINEA pepe OF = SN ; metier EEE e een ow ARE AY i Shai À \ SAR siycoprotein (80: ae ; : : enr Peace EER i = 37 Sy 3 | 435 03 >Cov-2 spike

A co ; ERE | it A RO 7058 PYREFNGIG } i | Chain A, SAR eine POI EN DO RES A ALLA IUD i ERA co ; ERE | it A RO 7058 PYREFNGIG } i | Chain A, SAR a POI EN DO RES A ALLA IUD i ER

CREE ERR licks (SEQ ID NO 123 | HL | YRENGIGMTCREE ERR licks (SEQ ID NO 123 | HL | YRENGIGMT

Ta AR Antie enr Peed WINS (ste | ENTa AR Antie enr Peed WINS (ste | EN

HLA-B ADUGSN pente | NM ER | TEHLA-B ADUGSN pente | NM HE | TE

N Datentanmeldung en buroisohe FPatentanmel GN Data registration and office patent application G

Luxemburgische FaLuxembourg company

IR 59 2093 23.02.2023IR 59 2093 23.02.2023

PRICK Gmbh fn MARC ViraPRICK GmbH fn MARC Vira

PMG S008. EL UD)PMG S008. EL UD)

De en ee. yo best I 1 id Protein oo 2 Nucisocaneid Protein I _De en ee. yo best I 1 id Protein oo 2 Nucisocaneid Protein I _

SARS-CoV-2 Nucleocapsic eeSARS-CoV-2 Nucleocapsic ee

Tabl 2, S/ NeW E a =Tabl 2, S/ NeW E a =

Table 2, SARS oo — die à, + A Ti Y RN X Ÿ _ nes Mb A Pa tie { moat onTable 2, SARS oo — die à, + A Ti Y RN X Ÿ _ nes Mb A Patie { moat on

TU Subtypes | HLA PeptideTU Subtypes | HLA Peptides

TTT HES ubtvne PELL }TTT HES ubtvne PELL }

LA Foot ve } cs i | | \LA Foot ve } cs i | | \

AY A tog Myo | Anecifie iAY A tog Myo | Anecifie i

LA PROT | Specific i i i i | Ÿ / von. | | | menrsesscnnes cms ! | Antigen | | i ES Ral caren : i i | i PE TTY TRA Savon i } ; ; | decane, CREE i | Variant i | remand EST PASSER ! | Variant i memento SET TRS po : i ! A ERT 573 i i TERE RARE TERTLA PROT | Specific i i i i | Ÿ / from. | | | menrsessscnnes cms! | Antigen | | i ES Ral carene: i i | i PE TTY TRA Savon i } ; ; | decane, CREE i | Variant i | remand EST PASSER! | Variant i memento SET TRS po: i! A ERT 573 i i TERE RARE TERT

CRATE FRROQGWPI | 3,8 | EN } : seen een 0702/ 1 FPROOQG | Ue ial (80-883) — ! Sirens | HLA-BO702/ ; | PRUE KO ee i TRE NOI 3 LA ; | | KU + PSI Droles TE i aaa een sptide (SEQ ID-NO1 7 ; : ! | Tree SEE enone Di = hmm & di cut Es AS LUKE Phen ' H Meneame RTI (ES puis ; de np SS ART red: À X Lam X m. = TED CavsCRATE FRROQGWPI | 3.8 | EN } : seen een 0702/ 1 FPROOQG | Ue ial (80-883) — ! Sirens | HLA-BO702/ ; | PRUE KO ee i TRE NOI 3 LA ; | | KU + PSI Droles TE i aaa een sptide (SEQ ID-NO1 7 ; : ! | Tree SEE enone Di = hmm & di cut Es AS LUKE Phen ' H Meneame RTI (ES puis ; de np SS ART red: À X Lam X m. = TED Cavs

Ii AIR Ar IL MCE Patan AT 1 | nn ARZT ER SE bo FA AY ts oH AR TANT ! Sn SEE Vers TA SATIi AIR Ar IL MCE Patan AT 1 | nn ARZT ER SE bo FA AY ts oH AR TANT ! Sn SEE Vers TA SAT

Pom LAS i renee enna EATS Shan A [ BOT | KFRORRTAT | 44056475Pom LAS i renee enna EATS Shan A [ BOT | FROSTED ACTION | 44056475

STE TOLLE | KEROKRE i Dan EA } TOES TR METI THAT i { SF re 7 ; Naan Data (SEC IE NG 4 SI 40 : Ï +0 RFA ETES FTSTE GREAT | KEROKRE i Dan EA } TOES TR METI THAT i { SF re 7 ; Naan Data (SEC IE NG 4 SI 40 : Ï +0 RFA ETES FT

Fries tigen peptide (SEG ID i Ama 1 | TRAOIIIEE REUPOUS pocleons poid àFries tigen peptide (SEG ID i Ama 1 | TRAOIIIEE REUPOUS pocleons poid à

La A + Ante TN Let aL \ Si AURAI 3 i smoot Hi = 8) TPS 5La A + Ante TN Let aL \ Si AURAI 3 i smoot Hi = 8) TPS 5

LILAS Antig } | HLA-ROSSI ! ra en 2055 Than A GAREPURPLE Antig } | HLA ROSSI! ra en 2055 Than A GARE

H TRAYNUTIRE U TSET 40,55 i SERA EVITA EE 155]H TRAYNUTIRE U TSET 40.55 i SERA EVITA EE 155]

Ï TERT AYNVTQAI | a nd ; No X A AREA La LL i ene | HLA-BSE ; | =: __ i nnn fide (SEQ ID NO } i mma: NUISARS neverÏ TERT AYNVTQAI | and ; No X A AREA La LL i ene | HLA-BSE ; | =: __ i nnn fide (SEQ ID NO } i mma: NUISARS never

Fm TH DENTICE (OI 10 ; na | { re Corea SAREFm TH DENTICE (OI 10 ; na | { re Corea SARE

D HLA-R Antisen PEptiae | lit A 04 Bot | { ss mean retD HLA-R Antisen PEptiae | lit A 04 Bot | { ss mean ret

LILAS ARNG | HLA-BTSOT ! Pr me dl RUCEPOSPS 1 i Pre 7 ; i PASSAGEN TER =PURPLE ARNG | HLA-BTSOT! Pr me dl RUCEPOSPS 1 i Pre 7 ; i PASSAGES TER =

PORTA > X : ST TE Pur ST | NUCIGOCEI 1 ; a INSTR ONT Pll Ÿ © ŸPORTA > X : ST TE Pur ST | NUCIGOCEI 1 ; a INSTR ONT Pll Ÿ © Ÿ

Bas ; EV Ris VE x i = An ry À XBas ; EV Ris VE x i = An ry À X

OR LABRET | AHOT (315-334 ; menerOR LABRET | AHOT (315-334 ; mener

SÉCID Gt © SEE ; X | Ÿ HDG 1 a _SÉCID Gt © SEE ; X | Ÿ HDG 1 a _

Antigen fide (SE WH L2 NS X i | 880 | | _ _ {HLA-B Antigen pe pude (DER | | I SI a a | i X manned Tp oo | | ERAGE Lan An | nuciencaps iAntigen fide (SE WH L2 NS X i | 880 | | _ _ {HLA-B Antigen pe pude (DER | | I SI a a | i

CERSSI TARAEF GMSR | 202,41 1 Th AAeT ASAFFGMS! | IE veCERSSI TARAEF GMSR | 202.41 1 Th AAeT ASAFFGMS! | IE ve

DT AS Antics N peptide {Gadd i ; | N MM Sen N TEDT AS Antics N peptide {Gadd i ; | N MM Sen N TE

HLA-A AT SGH N } i ne ES 9 yor X i APR TYR hii ; i bee TERT : X eb SASSFÉ CEHLA-A AT SGH N } i ne ES 9 yor X i APR TYR hii ; i bee TERT : X eb SASSFÉ CE

TA SU LA ÄRA | FAFSASAI Ce >TA SU LA ERA | FAFSASAI Ce >

SEN ID NC 14 Hi PASS LS ! 2 ino ISEN ID NC 14 Hi PASS LS! 2 ino I

N Antigen fick {oid Aono J i sos oo | _ _ l'HLAA A ntigen pentide (SEO ML Noté | Jon Co ;N Antigen fick {oid Aono J i sos oo | _ _ l'HLAA A ntigen pentide (SEO ML Noté | Jon Co ;

Ames ol HLA-A2GO1 | SOA Ri pereAmes ol HLA-A2GO1 | SOA Ri pere

So | HLA-AZUGT | etSo | HLA-AZUGT | et

REET Qo a Vf 2 45REET Qo a Vf 2 45

ARTERY 1 AGFAPSABA | 82.48 | iARTERY 1 AGFAPSABA | 82.48 | i

NO i * " 6 So i WHER we ’ 0 ST | EN aaaNO i * " 6 So i WHER we ’ 0 ST | EN aaa

HLA-B Antigen sept \ ; i eeeeenaesHLA-B antigen sept \ ; I eeeeeen

PLAGE Ar pathy à | | a . ı : APLAGE Ar pathy à | | a. ı: A

A nn i A N } A N aA nn i A N } A N a

AA

A5 aa 23.02.2023A5 aa23.02.2023

ST CreedST Creed

PRICK Gmbh _,PRICK GmbH _,

BODOG ELLYBODOG ELLY

PMCL008-F LU)PMCL008-F LU)

Tate 3 QARSOAV.Y Envelone ProteinTate 3 QARSOAV.Y Envelone Protein

Table 3, SARS-CoV-2 Ervelose ProteinTable 3, SARS-CoV-2 ervelose protein

TS PE TE rE eer ;TS PE TE rE eer ;

A. 2e RITE DES :A. 2nd RITE OF :

I LA ISOTYHE > AR i } ; i ! EL, ! : is | 5 Sad ! ; ; | Specific ! | Vaiue ! ! | SPGGIS ; VaR i i ; i ; | Antison ! ; i ; | ANUSSN- i i ; i ! i i i ; i ; | fait ! i !I LA ISOTYHE > AR i } ; i! EL, ! : is | 5 Sad! ; ; | Specific! | Vaiue! ! | SPGGIS ; VaR i i ; i ; | Antison! ; i ; | ANUSSN- i i ; i! i i i ; i ; | fair! i!

A wa i !Oh yeah!

Yanan i Ë ; mrsansasennesnnennnennnecn nd i : i mee eee en i : museseseemeeenenenenseneennennendennsenneenenn sen nennes A CES EYRE To A100 Dralen TISARS-CoV-A {48-75 : s Antisen nentine (Si * Li A ANSE PATE VR TRANS à | ENVEIODE PIOIEIN [DARS-GOV- 2} (40-209Yanan i Ë ; mrsansasennesnnennnennnnecn nd i : i mee eee en i : museseseemeeenenenenenennennendennsenneenenn sennamens A CES EYRE To A100 Dralen TISARS-CoV-A {48-75 : s Antisen nentine (Si * Li A ANSE PATE VR TRANS à | ENVEIODE [DARS-GOV- 2} (40-209

CHAR Anlagen pentds (SEQ ID NO BHT A-ATIOT | VSLVKRSEY 1100763 | ENVEIODE protean (DAIRXS +4 } ;CHAR attachments pentds (SEQ ID NO BHT A-ATIOT | VSLVKRSEY 1100763 | ENVEIODE protean (DAIRXS +4 } ;

ELA ANNGEN pEpiide (SEA Ne à HLA-A ! i ! errr enedELA ANNGEN pEpiide (SEA Ne à HLA-A ! i ! errr ened

OO PURES OE ARSE TSE :OO PURES OE ARSE TSE :

RR Eden ee REA TE NR TSR TTT SAQDOT | SLVKPSFYV 19041 | envelope protein [SARS-CoV-2] (49.75)RR Eden ee REA TE NR TSR TTT SAQDOT | SLVKPSFYV 19041 | envelope protein [SARS-CoV-2] (49.75)

HLA-A Antigen peptide (SEQ ID NGL22) | HA AUKUT | SLVT Ï DS, i i]HLA-A antigen peptide (SEQ ID NGL22) | HA AUKUT | SLVT Ï DS, i i]

I . = . : . H i + terre ee “m ET :I. = . : . H i + terre ee “m ET :

X aan rma ~ ~~ ; ~ - CIODTEXSEUR RE SUITE Es :X aan rma ~ ~~ ; ~ - CIODTEXSEUR RE SUITE It :

Ï CT ANS RTS AIR RNA LA ry PES ry AU ES ESA a GS des a | ONVESIOGE DIOISIM [SARS-CoV (45-75) } fa SES AD NOY 0 1 ME ALARM 1 SRVYUV ARV | RAR 18 | ONVEIODE Protein [SARE-G 1 ;Ï CT ANS RTS AIR RNA LA ry PES ry AU ES ESA a GS des a | ONVESIOGE DIOISIM [SARS-CoV (45-75) } fa SES AD NOY 0 1 ME ALARM 1 SRVYUV ARV | RARE 18 | ONVEIODE protein [SARE-G 1 ;

HLA-A Antigen peptide (SEQ IDNO/28) 1 HLA-AQ0301 | SFYVYSRVK | 648,15 er pe : {HLA-A Antigen peptide (SEQ IDNO/28) 1 HLA-AQ0301 | SFYVYSRVK | 648.15 er pe : {

AILA-A ANUGEN DE DUUS (SEW INU LE bass ! i fred = i ek - ERE RIUTR AAR: :AILA-A ANUGEN DE DUUS (SEW INU LE bass ! i fred = i ek - ERE RIUTR AAR: :

A _ Ps ee Pere RARE OU RASEA _ Ps ee Pere RARE OU RASE

CHAR Adie ntide (SEQ ID NO.24; | HLA-RI5SOT | LVKPSFYVY | 1411 | 'ENVEIODE proten PARS-COV-2T € }CHAR Adie ntide (SEQ ID NO.24; | HLA-RI5SOT | LVKPSFYVY | 1411 | 'ENVEIODE proten PARS-COV-2T € }

LHLA-B Antigen pentide (SEQ ID NO./24) | TILA-STOUT LVR | i PER PER AIRELHLA-B Antigen pentide (SEQ ID NO./24) | TILA-STOUT LVR | i BY PER AIR

ET TRE ET ER TEE TEE dm nun PE eeET TRE ET ER TEE TEE dm now PE ee

Fo À Antisan nontide (OR: X NO 25) ILA-EDEOT I NSSRVFDLL 1311, ; pe:Fo À Antisan nontide (OR: X NO 25) ILA-EDEOT I NSSRVFDLL 1311, ; pe:

HLA-E Antigen peptide {SEQ ID NG.:25) | HLA-ESE i i i i] oo I 2 . ! | + : BR anne De i eee bre Fee eT RARE EI TRE fmsemmmnsans sane ee Tiber ASIN ITY REY OES PLA DORN VY SRVENL | 250 59 | envelope protein [SARS-Col-2] { ÀHLA-E Antigen peptide {SEQ ID NG.:25) | HLA-ESE i i i i] oo I 2 . ! | + : BR anne De i eee bre Fee eT RARE EI TRE fmsemmmnsans sane ee Tiber ASIN ITY REY OES PLA DORN VY SRVENL | 250 59 | envelope protein [SARS-Col-2] { À

HLAR Antisen nentide (SEO ID NO 281 TILA-RUOUT 1 CVS VIOINE JON i ; 1 A = AM Hee F TE x PPT ; Ï Z | ; R i mmm mmm mmm mamma mmm mamma mmm mmm mmm mmm mmm mnt be = - À ANNE.HLAR Antisen nentide (SEO ID NO 281 TILA-RUOUT 1 CVS VIOINE JON i ; 1 A = AM Hee F TE x PPT ; Ï Z | ; R i mmm mmm mmm mamma mmm mamma mmm mmm mmm mmm mmm mnt be = - À ANNE .

EN Sr Luxemburngische PatentanmeldungEN Sr Luxembourg patent application

SE 28.02.2023 Luxemburgische PatentenmeldungSE 28.02.2023 Luxembourg patent application

PMC-0005-FLU7 LON 2PMC-0005-FLU7 LON2

PMCL008F LU)PMCL008F LU)

0404

Tabada A ADD Sal Oren even Dive beni tabi 4, SARS-COV-Z Surface FrotenTabada A ADD Sal Oren even Dive beni tabi 4, SARS-COV-Z Surface Froten

MA TSotype | SUDIYpe {FILA MSPUGS | Reason | TATQ8 ronan i i y; $ i i i i i i PL i ; : | Anne ifie } } Vaine N :MA TSotype | SUDIYpe {FILA MSPUGS | Reason | TATQ8 ronan i i y; $ i i i i i i PL i ; : | Anne ifie } } Vaine N:

SPGGIS ; | Vaiue | i : 5 i 3 i i : | 1 X Ÿ x : | 1 X Ÿ x i } cs i i i i | Antigen i ; | iSPGGIS ; | Vaiue | i : 5 i 3 i i : | 1 X Ÿ x : | 1 X Ÿ x i } cs i i i i | Antigen i ; | i

ANSQEM- ; i | i : ~ X X Ÿ x : | 1 X Ÿ x : | 1 X Ÿ x : | x 1 X Ÿ x : Ava : ; | i ! | Variant i i | i } X Ÿ : i sessed dndANSQEM- ; i | i : ~ X X Ÿ x : | 1 X Ÿ x : | 1 X Ÿ x : | x 1 X Ÿ x : Ava : ; | i! | Variant i i | i } X Ÿ : i sessed dnd

LE sss nats enna sn nanan forme Foren FareedLE sss nats enna sn nanan forme Forums Fareed

HLA-À Antigen peplids (SEQ ID NQ27 1 HLA-A0201 VINDILSRE 338.57 Chan À, FACE GIVOODIOTSIN DANS KOMMEHLA-À Antigen peplids (SEQ ID NQ27 1 HLA-A0201 VINDILSRE 338.57 Chan À, FACE GIVOODIOTSIN DANS KOMME

LHLA-A Antigen peptide (SEQ ID NO 273 | PILA-ALEGI | VEND SR | 5291 LEIA, SURGE YCOOHIOLE i ii : x T : X X Ÿ i : | 1 X Ÿ x : Ï X X Vena Amen : { ! | | (972-568) ; i 3 ; | | FE i 1 X X X x + x à À U ; mraneremeennsennes nes ne entame sement menant remet nent mean een enne nent enneennenen een een fn nen creme nan ennemie amen anna weanedLHLA-A Antigen peptide (SEQ ID NO 273 | PILA-ALEGI | VEND SR | 5291 LEIA, SURGE YCOOHIOLE i ii : x T : X -568) ; i 3 ; |. |. FE i 1

RER + : - = dem Leos ceases meena TERESTRER + : - = dem Leos ceases meena TEREST

TR 7 VAN NUT SENT STE > HR A Biron EEE ISLES ESTATR 7 VAN NUT SENT STE > HR A Biron EEE ISLES ESTA

PL ALE Antisen nantide (SES IN NO ZA TU A.GRRON SIH 151551 | Chain A, Surface Giveonratain SARS-OoV-ZTPL ALE Antisen nantide (SES IN NO ZA TU A.GRRON SIH 151551 | Chain A, Surface Giveonratain SARS-OoV-ZT

PLAST ANTIQEN DEE {Held HD NOLS; | HILA-SDOUT AGO VISE 15 10,07 | LRA À, SURE GH ï i ! x } x i i ! { Ë : | 1 X Ÿ x i i : ; leva son i i i i i | {872-588} ; : i i HEHE Ce) i i 3 ; i { A APLAST ANTIQEN DEE {Hero HD NOLS; | HILA-SDOUT AGO VISE 15 10.07 | LRA À, SURE GH ï i! x } x i i ! { Ë : | 1 X Ÿ x i i : ; leva son i i i i i | {872-588} ; : i i HEHE Ce) i i 3 ; i { A A

PRHOR GrobHPRHOR GrobH

PROR Grant = ;PROR Grant = ;

PMC-0005-F-LUNE 23.02.2023 Luxemburigisohe Patents nmeldungPMC-0005-F-LUNE February 23, 2023 Luxembourg patent application

PMCL008F LU) 28.02.2023 Luxe 3 GPMCL008F LU) 02/28/2023 Luxe 3 G

IoIo

OG esOG it

TTT XTTT X

TT X a ee ie fio WILT we RomTT X a ee ie fio WILT we Rome

Lu Sieur | Targa! Frotei 2 ORF1ab Protein a. =Lu Sieur | Targa! Frotei 2 ORF1ab protein a. =

ARS-C OÙ SONATA COIN a. 1 ee TOURS SU | Ranch oo chives | HLA Peptide iARS-C OÙ SONATA COIN a. 1 ee TOURS SU | Ranch oo chives | HLA peptides i

HERR pm nn HL ;MR pm nn HL ;

TTT IS shtyne 3 co : fair a | Subiyg ' Tn a i 1° ore is ieTTT IS shtyne 3 co : fair a | Subiyg 'Tn a i 1° ore is ie

ER SE CN JL i a7 4.488 3 wt | | | RON vein Tew {& A RS. Go y = { _ vs [ SE JR à ny rolain {SAT 74-458)ER SE CN JL i a7 4.488 3 wt | | | RON vein Tew {& A RS. Go y = { _ vs [ SE JR à ny rolain {SAT 74-458)

TUTEEETES polyprotein { MhTUTEEETES polyprotein { Mh

TT | 3 RE FAM pb aw reece = ; N 2 = = TE ore . UN TRAREURSUSE 374-355)TT | 3 RE FAM pb aw reece = ; N 2 = = TE ore. UN TRAREURSUSE 374-355)

Variar + i oe = oi : :Variar + i oe = oi : :

STSAFV | 44 8 | BA re ; 5STSAFV | 44 8 | BA re ; 5

I EN ê I ASE S et saratein (SAI aSI EN ê I ASE S et saratein (SAI aS

A Nandi mt SS polypratein € a [re REET ERE poly eraA Nandi mt SS polypratein € a [re REET ERE poly era

Eni = = i T TSH 1 © X N A A = =Eni = = i T TSH 1 © X N A A = =

IRR gan DEM Fos Mi | SCIRR gan DEM Fos Mi | SC

Lou Ini SEC TO NO 130) HLA Le ba a hide (SEQ LUA} err a. 5 a hit - ALCAZAR SFSASTSAI i 5. usLou Ini SEC TO NO 130) HLA Le ba a hide (SEQ LUA} err a. 5 a hit - ALCAZAR SFSASTSAI i 5. us

ZA Es NE EE Ee ISFS, { oo i. = EEE N30 | HLA-A2409/ | | or a.ZA Es NE EE Ee ISFS, { oo i. = EEE N30 | HLA-A2409/ | | or a.

Mi . ; SS er SD NG 31h X MAL i | | oo _ | 5Wed. ; SS er SD NG 31h X TIMES i | | oo _ | 5

FUE ELLE : eT ORF1ab DONE AR 35 A A nn - be De es | y ; tein (57 Se ooFUE ELLE : eT ORF1ab DONE AR 35 A A nn - be De es | y ; tein (57 Se oo

Ne Lo A. ; NTI NAC AT | polypre | iNe Lo A. ; NTI NAC AT | polypre | i

AE : = SL : ST. ; 1 DAS Ÿ X = 4 ws à ana nn... i een TS iH A NOR Te mean proton (SA TS ed = - = x "x LER A LAURE, rs oo x. To er = es = ke ; - LA-AOS 1 | Si F FAO | | SEP : = = = ; ; SE 8 on i 57 1 HLAADRO {SL § 216.12 oT = = I i ; NO a | Si A ; Cd Le : pre on = 5AE : = SL : ST. ; 1 DAS Ÿ X = 4 ws à ana nn... i een TS iH A NOR Te mean proton (SA TS ed = - = AOS 1 |. Si FAO |. SEP : = = = ; ;

Ni SRE ÉGIDNO 35) 1 FLAS 57 ev rh TE se = ue : en en SUTTER SIFFOVV ! 450,6 oR Sa = = me SE A-A5407 1 IGASLEFFOV RE ha 573Ni SRE ÉGIDNO 35) 1 FLAS 57 ev rh TE se = ue : en en SUTTER SIFFOVV ! 450.6 oR Sa = = me SE A-A5407 1 IGASLEFFOV RE ha 573

Aa i Sn NT A AAT PL Si RES Se | sure co hs DEE adr HLAAD 402 | ane + pa Rs 3 i SEQ ONO SR ttes { CET REST TES TE | TS ha — i Rt le SEE SET ASLPFOWLI TSF, mme Me SE oe - Le © SAE THAR 5801 : GLS | ~ ze _ SS Ss 7 becceeeeceneecnnes et 1 DS DNS x SET A mason X ima TOE] fei ha a a NOES | HLA-55061 i ins | Sar sev » ns © oa - : SD NO NER) + VILLE te i ns el ser ET = 2 i : ie (OF - _ _ BE Sha dnp = :4D 2,011 | ORF | © on 5 = een = [ = ; hi" AGA IR } A Similar i nd hil i ; on ah “THC A030 PAT re SET | :Aa i Sn NT A AAT PL Si RES Se | sure co hs DEE adr HLAAD 402 | ane + pa Rs 3 i SEQ ONO SR ttes { CET REST TES TE | TS ha — i Rt le SEE SET ASLPFOWLI TSF, mme Me SE oe - Le © SAE THAR 5801 : GLS | ~ ze _ SS Ss 7 becceeeeceneecnnes et 1 DS DNS x SET A mason X ima TOE] fei ha a a NOES | HLA-55061 i ins | Sar sev » ns © oa - : SD NO NER) + VILLE te i ns el ser ET = 2 i : ie (OF - _ _ BE Sha dnp = :4D 2,011 | ORF | © on 5 = een = [ = ; hi " AGA IR } A Similar i nd hil i ; on ah “THC A030 PAT re SET | :

I PALS Antis SY m po 1 pai fy MVE | a {HLA-A ATUZEN | I HUE | >I PALS Antis SY m po 1 pai fy MVE | a {HLA-A ATUZEN | I HUE | >

Sl yantide (SEQ ID NO-371 | | A ner n fide N TAN LE IN ; i ee antide (SEQ | LAST i . eee sy hosntiqoe \ Paar ans Wd i i l'HLA-R Antigen pe pi AE orSl yantide (SEQ ID NO-371 |

HLA-B Antigen : LR IHLA-B Antigen : LR I

Pil | - mmm maePil | - mmm mae

Patentanmekiung iigische Patentanm cemburgischePatent application iigische Patent application cemburgische

Luxemburg 28.59 2093Luxembourg 28.59 2093

LANL AVELANL AVE

SOR GiniSOR Gini

PRCR Gao urPRCR Gao ur

PMC-C005-FLUE2)PMC-C005-FLUE2)

pe a8pe a8

Pains EF EN A EIEN VAN SN can eT en LET AA avn Dw a on a mé Dod ny oePains EF EN A EIEN VAN SN can eT en LET AA avn Dw a on a mé Dod ny oe

Tahlia KR {ARE MES enapnifiis WDA antinan nantitaeTahlia KR {ARE MES enapnifiis WDA antinan nantitae

PREIS 0, GARS-GOV-S SPECT MLA antigen DODIICESPRICE 0, GARS-GOV-S SPECT MLA antigen DODIICES

LMI À antfinen sandals | igentifisatinn Net 1 Tarnet Dratain | Mintshine EnfésneLMI À antfinen sandals | igentifisatinn Net 1 Tarnet Dratain | Mintshine Enfesne

RLA SS! Poptide | MOSITIICATION ND, 1 rargst Frais | Maithing EPHOPS |; vaintan tn Dan RIM | I RADS ALD i related to {Pep NO} i POARS-CoV-E !RLASS! Poptide | MOSITIICATION ND, 1 rargst Frais | Maithing EPHOPS |; vaintan tn Dan RIM | I RADS ALD i related to {Pep NO} i POARS-CoV-E !

DAMIR ARAND ON Omen NOY - RQ es PR poil MT :DAMIR ARAND ON Omen NOY - RQ's PR poil MT :

ANIRAGANL (81) | SEC-ID NO. SS SE PE cell, HTLANIRAGANL (81) | SEC ID NO. SS SE PE cell, HTL

PAS ARDS A ATE SON MDN IY RECN AIN HE POR madi RAT :PAS ARDS A ATE SON MDN IY RECN AIN HE POR madi RAT :

Se SAAN A # Lobe f ASH = La La SANT heSe SAAN A # Lobe f ASH = La La SANT he

ASANLAATK {1} DEG-ID NG 60 Be SCO THE ;ASANLAATK {1} DEG-ID NG 60 Be SCO THE ;

DO ANDREA UN Omen NOY CR es PONTDO ANDREA UN Omen NOY CR es PONT

AYRFENGIGV (7) | SEQ-D NO 61 SE OTLAYRFENGIGV (7) | SEQ-D NO 61 SE OTL

ORNS SNENE A ANS /4 A\ ONE ITY ONES RSS HE DEN aad ;ORNS SNENE A ANS /4 A\ ONE ITY ONES RSS HE DEN aad ;

PRADA EA ARE (19) | SEQ-ID NO 82 Poel 1 CONPRADA EA ARE (19) | SEQ ID NO 82 Poel 1 CON

EUR EE EEE fa 0 STAR RAR ES FRS Eee ; } NS LS TRIO PAPA + RAT TE dtd + + SAT EN :EUR EE EEE fa 0 STAR RAR ES FRS Eee ; } NS LS TRIO PAPA + RAT TE dtd + + SAT EN :

LG YF OR CT 2) DESTINE. DO DE DAL ;LG YF OR CT 2) DESTINE. DO DE DAL ;

DOESN CHOSE YL STE LE SN ITR ONES DA En Does :DOESN CHOSE YL STE LE SN ITR ONES DA En Does:

Poi SE YN oy + QE AY NEY fat Pe POT }Poi SE YN oy + QE AY NEY fat Pe POT }

PLEO LIN Poonam iS NO. SS Dé PAs !PLEO LIN Poonam iS NO. SS Dé PAs!

OEE SIDIDI AVES SON ENE IPN APR ONE i A Em pe } i à KEANE aan DOANEIOLIMY AS RE Pam Par oo iOEE SIDIDI AVES SON ENE IPN APR ONE i A Em pe } i à KEANE aan DOANEIOLIMY AS RE Pam Par oo i

PLA NAVY EY (eV) SES INK DO LINE HILL ELPLA NAVY EY (eV) SES INK DO LINE HILL EL

Jrmmmentenen nes ten nennnn tn Ann NAN EAU A ANNEE EAN E EE AA tee iit tees EAN UNE EEE A ANNEE EEE A ANNEE CAN annJrmmmentenen nes ten nennnn tn Ann NAN EAU A ANNEE EAN E EE AA tee iit tees EAN UNE EEE A ANNEE EEE A ANNEE CAN ann

L'EST DIVERS SAM DOESN ITS NES AR boone PowayL'EST DIVERS SAM DOESN ITS NES AR boone Poway

PEYVEGRRLM (13) SEC-ID NO. 88 iS HE ; ETERS SOL AEN A + ON | QUES IN ARS ST |A Ty : EF mal! ;PEYVEGRRLM (13) SEC ID NO. 88 iS HE ; ETERS SOL AEN A + ON | QUES IN ARS ST |A Ty : EF times! ;

CN | DELAI NLA OF PN Pony Gen ;CN | DELAI NLA OF PN Pony Gen ;

OREN ETRY BANN SX TOSSES IFR AR DD Es SORT! NTI ;OREN ETRY BANN SX TOSSES IFR AR DD Es SORT! NTI ;

FOFINGVOY (8) | SEC-IS NO. 658 SZ HILL, OTLFOFINGVOY (8) | SEC-IS NO. 658 SZ HILL, OTL

ENTER Tar EN EE TS PARTIR IPN ESTER NS NS iENTER Tar EN EE TS PARTIR IPN ESTER NS NS i

CONTI IV RW PA PRESLID NOY CAD | Q4 Pe ;CONTI IV RW PA PRESLID NOY CAD | Q4 Pe ;

FEY ERY GRR (ir; {STAR NO: 69 LAB | LeiFEY ERY GRR (ir; {STAR NO: 69 LAB | Lei

PASS ENS AU CN PSP RE EE Coney TL ES ;PASS ENS AU CN PSP RE EE Coney TL ES ;

GYOPYRVVY (6) | SEG-ID NO. 70 ;S2 HILL CTLGYOPYRVVY (6) | SEG ID NO. 70 ;S2 HILL CTL

L'RD\FTONRAT VS EM RES AN + 74 | POT ;L'RD\FTONRAT VS EM RES AN + 74 | POT ;

Poa QNVLY (7) | DEG-ID NO 7/7 LE SENPoa QNVLY (7) | DEG ID NO 7/7 READ SEN

TERT aan TSR DEE IR TEES oe DT ATERT aan TSR DEE IR TEES oe DT A

KOLSPRAWYEF (20) | SEC-ID NO: 72 NS iHTL CTU ;KOLSPRAWYEF (20) | SEC ID NO: 72 NS iHTL CTU ;

DORADO ANT ON PROGID ND - TA PND PR pall ;DORADO ANT ON PROGID ND - TA PND PR pall ;

APINVPIOISAGEP (Tu) SEAL NO: 73 | NF PR CONAPINVPIOISAGEP (Tu) SEAL NO: 73 | NF PR CON

DIRK MTR 247) Omen NY Ta SA PT :DIRK MTR 247) Omen NY Ta SA PT :

PREY ORTH PY LT} DOES INL SS PE Pole !PREY ORTH PY LT} DOES INL SS PE Pole !

LE SDMANTVY SOM PROGID ND - TR ND PRT OT ;LE SDMANTVY SOM PROGID ND - TR ND PRT OT ;

List RWVYFYY {LW} Pasi NO: 75 | NE ER ELList RWVYFYY {LW} Pasi NO: 75 | NE ER EL

DONELSON ONDIVED (A LSENSVOINN AY TR ES PORTE ony :DONELSON ONDIVED (A LSENSVOINN AY TR ES PORTE ony:

NOVGOYQPYR (Gi Poli NO: 25 DE PTL, GL ;NOVGOYQPYR (Gi Poli NO: 25 DE PTL, GL ;

POTTER ET TRS IY PE TE TANT pry TTT IE :POTTER ET TRS IY PE TE TANT pry TTT IE :

DONE NES HE FT PRET NON + 77 1 PR sait £8 ;DONE NES HE FT PRET NON + 77 1 PR said £8 ;

PNLNESLIDL (18) | SEQ- 1 NO 77 Poel 1 CS, GilPNLNESLIDL (18) | SEQ-1 NO 77 Poel 1 CS, Gil

L'DVYIMAAA SE A DOREEN NY VO | DOREEN :L'DVYIMAAA SE A DOREEN NY VO | DOREEN:

PYRVVVLSF (© Pony NO: 25 DE HILL, GEL ; } CNRS ILSUA MASSE HEN | ARETE NAN - TO | Du i D sos it STE PSE }PYRVVVLSF (© Pony NO: 25 DE HILL, GEL ; } CNRS ILSUA MASSE HEN | ARETE NAN - TO | You i D sos it STE PSE }

OYTIKVVPUWVYT (15) | GEO-D NO. 79 SE PB ce HTL, CTLOYTIKVVPUWVYT (15) | GEO-D NO. 79 SE PB ce HTL, CTL

PMOR GmbHPMOR GmbH

PMC-CCCS-P-LU(ZI 28.02 2023 Luxemburgische Patentanmeldung exPMC-CCCS-P-LU(ZI 28.02 2023 Luxembourg patent application ex

SfSf

AAN SS Bed tite Osmhinatian maddie atingAAN SS Bed tite Osmhinatian maddie ating

Table 7 SARUCAV.D Dalvnantide Cambinatinn macicationTable 7 SARUCAV.D Dalvnantide Cambinatinn macication

Table 7, SARS-CoV-2 Polypeptide Combination medicationTable 7, SARS-CoV-2 Polypeptide Combination medication

FANS, SAR LOVE GI RERUGRE LOITIEFANS, SAR LOVE GI RERUGRE LOITIE

TT One pus (eu tr in NTT One pus (eu tr in N

PART AR NE a | iontifisatinn | Don NaPART AR NE a | iontifisatinn | Don Na

NO | ATHNG ACIG CONTIQIEX yt So Ÿ | iNO | ATHNG ACIG CONTIQIEX yt So Ÿ | i

ÏÏ

; | ; ey Enea : i ; | ar fi {; | ; ey Enea : i ; | ar fi {

HUMIDE! iHUMID! i

Ï i ; a dm nT mm ma a > & A ns HE) x N ; { ORAL PEU ARR AS OES OI RY any : Dan 1Ï i ; a dm nT mm ma a > & A ns HE) x N ; { ORAL PEU ARR AS OES OI RY any : Dan 1

Ua N er TAN EHEN ANSE Ale 8 | PaneUa N er TAN EHEN ANSE Ale 8 | Pane

A 11 ENKVTLADAGEIKFOYGDCILGTHAA | DELL NS SS reat à ALTE ELAINE INA AOL LS BAT LAAN ; | PE ET NR | gare sa TEN. DEN x} > mn TE NA 11 ENKVTLADAGEIKFOYGDCILGTHAA | DELL NS SS reat à ALTE ELAINE INA AOL LS BAT LAAN ; | PE ET NO | gare sa TEN. DEN x} > mn TE N

Poa PRY VOR ERIN EINEN 1 : ; Nb dp een BEN dnp pa X > & A a HE) x N ; : PEN ES Fe A RER AN TE Se $ - Pres D ENTER SINN RU EN x AN : Dan a {Poa PRY IN FRONT OF ERIN A 1 : ; Nb dp een BEN dnp pa X > & A a HE) x N ; : PEN ES Fe A RER AN TE Se $ - Pres D ENTER SINN RU EN x AN : Dan a {

PROPRES OVI TRON KDD Toman im Ale An | Pan 3 i DE DIREOVOONY NY YR RESNLKPEER ok IL NN. sy I FRU-0PROPRES OVI TRON KDD Toman in Ale An | Pan 3 i DE DIREOVOONY NY YR RESNLKPEER ok IL NN. sy I FRU-0

LA PTS OONNS ASE VR DISK WR HR | DE ND 40 ; i 13 | LDSKVGGNYNYLYRLFRKSNLKPFERLA PTS OONNS ASE VR DISK WR HR | DE ND 40 ; i 13 | LDSKVGGNYNYLYRLFRKSNLKPFER

NR RNRNREEMEMaLasamnaiasasassdesseraessissesseeeses tee N 1 ay Tm ji eee SN tN AA PoE een A 1NR RNRNREEMEMaLasamnaiasasassdesseraessissesseees tee N 1 ay Tm ji eee SN tN AA PoE een A 1

TT REE RATA PSEA ND AT 1 DanTT REE RATA PSEA ND AT 1 Dan

Poa LEDPEPRA EMI | DESSIN 40 Po HEPoa LEDPEPRA EMI | DESIGN 40 Po HE

PA PEEVEPA PEEVE

} : eo x X \ | } |! frafaranna i (reference) ; | 1 x Kr i} : eo x X \ | } |! frafaranna i (reference) ; | 1 x kr i

ÏÏ

; | X : A; | X : A

EE \ ; { PAP RTE ay pa Tame Ny Fray se omy Se N iEE \ ; { PAP RTE ay pa Tame Ny Fray se omy Se N i

CETTE AER È J FAR STE HN X MEN ITS ONY A5 : Dan. 5 ; i RRM DISORNTATKAYNVTOAFORRPE | EDAD ND AT PendCETTE AER È J FAR STE HN X MEN ITS ONY A5 : Dan. 5 ; i RRM DISORNTATKAYNVTOAFORRPE | EDAD ND AT Pend

Pr | QAATAQES DIEONWDTATK AVN STOAMGRHEERPE | DEV NO 42 et a 15 SAÄAKHADKKFROKRTATKÄAYTYNWVERAFGRNKFE ES § ! | mmm mm mmm + 1 : oh rn 1 a mame 1 Em em 1 > & A 5 HE) oS N ï PEAR TT ARE PoE AE D ENTER SINN RU EN x N DanePr | QAATAQES DIEONWDTATK AVN STOAMGRHEERPE | DEV NO 42 et a 15 SAÄAKHADKKFROKRTATKÄAYTYNWVERAFGRNKFE ES § ! | mmm mm mmm + 1 : oh rn 1 a mame 1 Em em 1 > & A 5 HE) oS N ï PEAR TT ARE PoE AE D ENTER SINN RU EN x N Dane

NS r BA WED mma, NY > A5 {DanNS r BA WED mma, NY > A5 {Dan

LT | MAYRENGISVTOAMLVE (SSR NC a4 1 rey # | MATE NO V'HLUN VE Fi ; | A ne Ress ee cesse e cesse sense + : ; ror hE hm ma arma x NTT X ee N A a us ex N ; | TONE À PLE EN IR On ESS 8 yoy LES TY af ~N x An 1 Dan 2LT | MAYRENGISVTOAMLVE (SSR NC a4 1 rey # | MATE NO V'HLUN VE Fi ; | A ne Ress ee cesse e cesse sense + : ; ror hE hm ma arma x NTT X ee N A out ex N ; | TONE À PLE EN IR On ESS 8 yoy LES TY af ~N x An 1 Dan 2

Ta TTS ave ï {CS NS SNS ON NS TONI ANS aX : Pan- iTa TTS ave ï {CS NS SNS ON NS TONI ANS aX : Pan- i

Ï Qi SSSR AA OSSI NSQRATERIME | NG 3 SEA TEL EN SY POTN ÏÏ Qi SSSR AA OSSI NSQRATERIME | NG 3 SEA TEL EN SY POTN Ï

Te PVSEVKBPESEY VY SRVKAH NSSNVPT / DEL NO AD i { | POLVRPSPFTVTONVÉNENSORN VILLL VTe PVSEVKBPESEY VY SRVKAH NSSNVPT / DEL NO AD i { | POLVRPSPFTVTONVÉNENSORN VILLL V

Dune eee eee TI ; 1 ; | pu aay SL An OE, pya vase as Frs AN Po a, Oy NDune eee eee TI ; 1 ; | pu aay SL An OE, pya vase as Frs AN Po a, Oy N

RAS NONI | SAL ND AS | Pana ÏRAS NONI | SAL ND AS | Pana Ï

Da | AATKMSECVLOOSKR VID (SSR NGL a reneThere | AATKMSECVLOOSKR VID (SSR NGL a rene

ASR RSL VGAASR RSL VGA

LL LAUDOYV LIN HON LIAN VELL LAUDOYV LIN HON LIAN VE

; | + A i ; + LL EN UT ee EEE EEE TEE X a ga ne yes ry pa Fa \; | + A i ; + LL EN UT ee EEE EEE TEE X a ga ne yes ry pa Fa \

TE TEE RS RESTE X DOE ON REN = AR 1 Dan TA 1 44 I FEGMSRIGMEVTRSCSTW | SEQ NO: 43 | PapiTE TEE RS LEFT X DOE ON REN = AR 1 Dan TA 1 44 I FEGMSRIGMEVTRSCSTW | SEQ NO: 43 | Daddy

Poi | FFESGMSRIGMEVTPSRO WY oA TL i Ï }Poi | FFESGMSRIGMEVTPSRO WY oA TL i Ï }

LE TEARS TONNES POS NYLE TEARS TONNES POS NY

; | SA + i ; ; A NE À A TNL Sin TONE EN TEN oa : Dan 17 i; | SA + i ; ; A NE À A TNL Sin TONE EN TEN oa : Dan 17 i

PES TAR SN SOIF S } SECGIT) NO - A0 | Pan 17 49 | AFAGTAAM(VRAIFS | SEO-ID NO 49 | Pep-12PES TAR SN SOIF S } SECGIT) NO - A0 | Pan 17 49 | AFAGTAAM(VRAIFS | SEO ID NO 49 | Pep-12

Dé ANASAARVYIROID | i ; | + a ; a EE EEE TETE N A gs oe a == Poe oY 1 EE AT POSEN GEN AN ZN : Dan x ïDé ANASAARVYIROID | i ; | + a ; a EE EEE TETE N A gs oe a == Poe oY 1 EE AT POSEN GEN AN ZN : Dan x ï

Loges Di SE EDEN [ENDL NO KN | Pen 413Loges Di SE EDEN [ENDL NO KN | Pen 413

PER TESVAGSADE! MIN! FORT |RSS HESS NO SU | PRBY TESVAGSADE! MIN! FORT |RSS HESS NO SU | PR

PI TERY WOME LIVIA | i ; X es fencnemne nner nena cenc canne ; | FE aaa anna ann + i ; ; RE SR Ra des TONE EN TEN - 4 : Dan TA iPI TERY WOME LIVIA | i ; X es fencnemne nner nena cenc canne ; | FE aaa anna ann + i ; ; RE SR Ra des TONE EN TEN - 4 : Dan TA i

TRATES \ SY } QED NID SA | Pan iATRATES \ SY } QED NID SA | Pan iA

PEER AOL GLS AVASTPEER AOL GLS AVAST

; + Lo En i ! | A AN A = ; : RR BR RUSS A em TTT 1 A gs oe a pres jeux AS : EAST POSES IN RS RS : Dan &; + Lo En i! | A AN A = ; : RR BR RUSS A em TTT 1 A gs oe a pres jeux AS : EAST POSES IN RS RS : Dan &

PRE | ERCLAENA ANT HAN PAT AUX PAQUIN AGEN Lu Paneth iPRE | ERCLAENA ANT HAN PAT AUX PAQUIN AGEN Lu Paneth i

X ~~ HEE RN aaa TYE, NAN NASA r HAM | SE AEH NO 52 Ban ueX ~~ HEE RN aaa TYE, NAN NASA r HAM | SE AEH NO 52 Ban ue

La SNS IRON WAH {ab tada | Ss LS i iLa SNS IRON WAH {ab tada | Ss LS i i

DES LGRYERQYIRWRWY RWLGHIAG : i NR +DES LGRYERQYIRWRWY RWLGHIAG : i NR +

TTY — a à pr 1 ; | FE PE ae ay Se ED en an À &TTY — a à pr 1 ; | FE PE ae ay Se ED en an À &

Ï RE TT ETS LOST SN IM, Rey DA | Dan =Ï RE TT ETS LOST SN IM, Rey DA | Dan =

Da | | "RHIN AS SENS NITY RA Pana iThere | | "RHIN AS SENS NITY RA Pana i

Pa DET I OI RIT INN AS Oase EL INLD DS Porras NEPa DET I OI RIT INN AS Oase EL INLD DS Porras NE

LUF DIVE RKIVRN TRING AS ITA LG ENA ; } {LUF DIVE RKIVRN TRING AS ITA LG ENA ; } {

TE LS KEY ork TE PINLVTE LS KEY ork TE PINLV

N mamma mamma mana \N mamma mamma mana \

TTS " Ha en 1 ; ; I i Tw, wn Sm NEN ner NEY Fa 2 RE VO > art 4 2TTS " Ha en 1 ; ; I i Tw, wn Sm NEN ner NEY Fa 2 RE VO > art 4 2

ES PRESSE MAT AUOT ; EAN OUT Nig a5 Pan. =IT PRESS MAT AUOT ; EAN OUT Nig a5 Pan. =

DAR aren KFPROOGVPINTNISSS | SEQ-ID NO: 55 | Fop-18 i aR : at x Nes = N So SE i §DAR aren KFPROOGVPINTNISSS | SEQ ID NO: 55 | Fop-18 i aR : at x Nes = N So SE i §

PAS ORDLLREPRGROGVFIN ENGR : ; + mamma een] ! | mmm mmm mR mm + - 1 : Ch pe 1 ow a a a pa RN a Ea) NPAS ORDLLREPRGROGVFIN ENGR : ; + mamma een] ! | mmm mmm mR mm + - 1 : Ch pe 1 ow a a a pa RN a Ea) N

Ï FETE TT SES | SISSN ITY A + ES | Dan Le {Ï FETE TT SES | SISSN ITY A+ES | Dan Le {

PT EWA AMET PEL SA AY | Fanp-19 149 | RPOOTDVKHUVDOUAGQKE | LDEU-HS NU OD TGS { 19 RU PLN KOMMWEHNLAUTPT EWA AMET PEL SA AY | Fanp-19 149 | RPOOTDVKHUVDOUAGQKE | LDEU-HS NU OD TGS { 19 RU PLN KOMMWEHNLAUT

N mamma mamma mana \ ; PTS ; Ha TN ; ; AT TE em TTT ae ge Fa rs rd Page x Na \N mamma mamma mana \ ; PTS ; Ha TN ; ; AT TE em TTT ae ge Fa rs rd Page x Na \

BR Tm amma | QUENT ANDY RT 1 Dan. 70BR Tm amma | QUENT ANDY RT 1 Dan. 70

TROLSPRWTFYYLOTA | SEQ NO 57 PERLTROLSPRWTFYYLOTA | SEQ NO 57 PEARL

Lan PAT ODA SITE | SEQ-IS NO 57 i { 120 KOLSPRWYFYYLGTG ; + a ! | mmm mmm mR mm + 1 : JP 1 > & A Pr HE) a N ; CETTE ITE A ENT OES OI NN BD : Dan >Lan PAT ODA SITE | SEQ-IS NO 57 i { 120 KOLSPRWYFYYLGTG ; + a! | mmm mmm mR mm + 1 : JP 1 > & A Pr HE) a N ; CETTE ITE A ENT OES OI NN BD : Dan >

Tag { “Ad QEIM_IM Ae AR : Dan.” tx AIT AS AND AATIAS PS NO 3 DOES }Tag { “Ad QEIM_IM Ae AR : Dan.” tx AIT AS AND AATIAS PS NO 3 DOES }

Lana | UD A ANIDA ARNE A ATWAS | SEC-ID NG 85 i {Lana | UD A ANIDA ARNE A ATWAS | SEC ID NG 85 i {

P21 | IRAARIRASANLAATM SE iP21 | IRAARIRASANLAATM SE i

PMCR GmbH 1 3 feed Toes been real meetPMCR GmbH 1 3 feed Toes were real meet

PMC-000S-P. 28.02 2023 Luxemburgische PatentanmeldungPMC-000S-P. 28.02.2023 Luxembourg patent application

PMC-CC0S-P-LU(Z) AOUE AV ED - UPMC-CC0S-P-LU(Z) AOUE AV ED - U

PMO-OG0S-P-LUCZ aePMO-OG0S-P-LUCZ ae

Be ee ve MathadBe ee ve Mathad

Hioinformatio Method with Bioinformatic ined with Riginf 119 determined with £Hioinformatio Method with Bioinformatic ined with Riginf 119 determined with £

A ALTO determin dates MI ALTO dateA ALTO determin dates MI ALTO date

Candidates MM tide Candidates A eensCandidates MM tide Candidates A eens

SOV-2 Polypeptide Candie orSOV-2 Polypeptide Candie or

SARS ON rd AY NM = ‘ aSARS ON rd AY NM = ‘ a

Table 8 SARS-Co Well Yi oo | _ a / oo ais er fe umber | No (Pe i 8 TT Ne Fife aan Nn UY OEY | { a {ident MORE NW | à SEN a SEN tetes npr ~ DE A on corner | NO 80 | Pan.Table 8 SARS-Co Well Yi oo | _ a / oo ais er fe umber | No (Pe i 8 TT Ne Fife aan Nn UY OEY | { a {ident MORE NW | à SEN a SEN tetes npr ~ DE A on corner | NO 80 | Pan.

Ve A fed sn EN SHE Ds [ - - 3. | Amino Acid Complex Hr EE A — {romeo EUR ino Acid Con ER anna a ES a A À 5-80 ; : | ll | cn : Sie RT A nn fa 5 i 5 E { 2- i 0D { >. | rere = sn VHAR (EAS AAR Pool br Sn zn VENANTAR GEI AGLIAIVA | 80 A n | AY ICAPWY IAL GF 1A (CHREY] PP meVe A fed sn EN SHE Ds [ - - 3. | Amino Acid Complex Hr EE A — {romeo EUR ino Acid Con ER anna a ES a A À 5-80 ; : | ll | cn : You RT A nn fa 5 i 5 E { 2- i 0D { >. | rere = sn VHAR (EAS AAR Pool br Sn zn VENANTAR GEI AGLIAIVA | 80 A n | AY ICAPWY IAL GF 1A (CHREY] PP me

X meen a vi IMA NS J ni 2 À i CT I es -X meen a vi IMA NS J ni 2 À i CT I es -

TTT REVERIE VY HEC Le 5 = —TTT REVERIE VY HEC Le 5 = —

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ANY ENGIN OF SITENO SCH, Ing i “à VsANY ENGIN OF SITENO SCH, Ing i “à Vs

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Sima an The an VI POLIS CO NASima and The an VI POLIS CO NA

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TSIErred 10 as antigen panne = NTSIErred 10 as antigen breakdown = N

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SEAR CIE Y SLA Garant a = : : ides across different proteins fisinhution of the combination peptides across different PICLGHESSEAR CIE Y SLA Garant a = : : ides across different proteins fisinhution of the combination peptides across different PICLGHES

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ECTS Win . ; © tat CLOT EI SE at ; cx invention is nmunocenis or notECTS Win. ; © did CLOT EI SE at ; cx invention is nmunocenis or not

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M1 DD 135 Po = D HER Hd | VS gE LUS US ï Ï ï ! X \ X i ï X È XM1 DD 135 Po = D HER Hd | VS gE LUS US ï Ï ï! X \ X i ï X È X

X H X = X X X ! X X È XX H X = X X X ! X X È X

X t X = X X X 1 X X È XX t X = X X X 1 X X È X

Em sssEm sss

RAM | ona | Da | i La A Les Va 48 1 AS | aan seRAM | ona | There | i La A Les Va 48 1 AS | aan se

PRASAD Qa oa HA ï ER : 4 A Poy 1 9 A5 Vote? PRL +2 XPRASAD Qa oa HA ï ER : 4 A Poy 1 9 A5 Vote? PRL +2X

PIVEN LN ON 1% Hl 3 EE La DOSE Poel LY OO ï Ï ï ! X \ X i ï X È X i | : } i } : | } | ;PIVEN LN ON 1% Hl 3 EE La DOSE Poel LY OO ï Ï ï ! X \ X i ï X È X i | : } i } : | } | ;

Hs A ee nennen eedHs A ee call eed

RSA LT pa Lan LADA Lau Poesy | 4 A La | es An LA sn Dean pes ÙRSA LT pa Lan LADA Lau Poesy | 4 A La | es An LA sn Dean pes Ù

ANR LRU X > DH Vf + v + 1 4 A to + 1 R An X rR È ARE A XANR LRU X > DH Vf + v + 1 4 A to + 1 R An X rR È ARE A X

NIS foot 115 PLY {1202 Pog HE PL | DAS Song Paina i i } Ï ! | ÏNIS foot 115 PLY {1202 Pog HE PL | THE song Paina i i } Ï! | Ï

X H X = X X X ! X X È XX H X = X X X ! X X È X

X t X = X X X 1 X X È XX t X = X X X 1 X X È X

A A | iA A | i

PETE TTT TE TEPETE TTT TE TE

RAR END | AR En | io Poa LA | A2 NAN LTRARE AR I (AIS IN 135 PU { — P< LAS 10 DES SUB Posh us ï Ï ï ! \ X i ï X È XRARE END | AR En | io Poa LA | A2 NAN LTRARE AR I (AIS IN 135 PU { — P< LAS 10 DES SUB Posh us ï Ï ï ! \ X i ï X È X

ED feeED fee

CREATOR T ER 7 5 ue PS are ae TRANSCREATOR T ER 7 5 ue PS are ae TRANS

RAA Tan | A Pr | 15 Ly 1A La: Lnag PAG DA 1RAA Tan | A Pr | 15 Ly 1A La: Lnag PAG DA 1

PRED | Dé PS LU tr te Li LA SD Pola PV ISEO i } Ï ! | ÏPRED | Dé PS LU tr te Li LA SD Pola PV ISEO i } Ï ! | Ï

X H X = X X X ! X X È XX H X = X X X ! X X È X

X H X = X X X ! X X È X i i | iX H X = X X X È X i i | i

TES TT TT rT TTT TI esTES TT TT rT TTT TI es

FRAGT | 29 | AS Das X SA 1 LA Le 72 IN A4 Ran 27ASKS | 29 | AS Das X SA 1 LA Le 72 IN A4 Ran 27

PIES Od PO USE i Po L £ Po POLE as [EA CI oI ï Ï ï ! X \ X i ï X È XPIES Od PO USE i Po L £ Po POLE as [EA CI oI ï Ï ï ! X \ X i ï X È X

X H X = X X X ! X X È XX H X = X X X ! X X È X

X F 1 = { + + 1 1 + ! :X F 1 = { + + 1 1 + ! :

En mmemmenneAnd mmemmenne

EY PY. 1 [PNP Tx i Ï Ta wn 3 : HIPPYEY PY. 1 [PNP Tx i Ï Ta wn 3 : HIPPY

ARE Ton | AM Ina | Po La bo favs N AS Paar AAARE sound | AM Ina | Po La bo favs N AS Pair AA

X H X = X X ! X X È XX H X = X X ! X X È X

Lm a ha baa an idLm a ha baa an id

EAC Saad iEAC Saad i

FMOR GmbHFMOR GmbH

0404

StSt

OSOS

24 _RA4R tides A Ti EO, the peptides WW24 _RA4R tides A Ti EO, the peptides WW

Holoo of | DOLL ing alisles of ths POI i TRSRONGING SHSISSHoloo of | DOLL ing alisles of ths POI i TRSRONGING SHSISS

Hd COTTESPONTING rage and CorresiHd COTTESPONTING rage and Corresi

HTL coverage ang o¢ { ooHTL coverage ang o¢ { oo

Ï ES-2: HT L VOTE 4 aÏ ES-2: HT L VOTE 4 a

Tabie 55.5: HTL aTable 55.5: HTL a

FAME ED a 1FAME ED a 1

A qAq

A 5.A5.

EE x i ale IY SN 5 4 Li i A - we - 2e Free SENT TE Sad FHL cover | - ho. EEE AMEN. = 4 i M 3 5 10 3 O1 ; m : . … oe nm Eat A PSS Aux, vi ; MGREE x i ale IY SN 5 4 Li i A - we - 2e Free SENT TE Sad FHL cover | - ho. EEE AMEN. = 4 i M 3 5 10 3 O1 ; m: . … oe nm Eat A PSS Aux, vi ; MGR

UNS. | HTL om erage Poy eee EEUS. | HTL om erage Poy eee EE

J noe - CARE EU AI ESS DNS HAT wo _ ANC EE AN “des SNS ; uJ noe - CARE EU AI ESS DNS HAT wo _ ANC EE AN “of the SNS ; u

Sn AD ATEN OVDOSTT PEPOTO MLA iSn AD ATEN OVDOSTT PEPOTO MLA i

OR OS HYPE PRLOR OS HYPE PRL

I ; or TA À - 3 A LES 3I ; or TA À - 3 A LES 3

Li 3 OT MULADRATT 0 N / | ve et AH ON àLi 3 OT MULADRATT 0 N / | ve et AH ON à

TP i i DPRTOROT HLA-U EnTP i i DPRTOROT HLA-U En

AA i i SOTAISDPET O0 bod rn MA wl ï D RSA 4 es ALIAS ORT crn ;AA i i SOTAISDPET O0 bod rn MA wl ï D RSA 4 es ALIAS PLACE crn ;

UPATOTES DRB1*472 04 HLA-DPRUPATOTES DRB1*472 04 HLA-DPR

PL . it A SETHE i i POA 01 HLA-DRRA } ï v x INI ANA ENT HILA-L i ! - : IVAN 04:01 1 } Lans es i ASO OR B1 i : 93 97 DRAN PORE : i _ { i ACY 0 _ ue i SRE TON ANNE LL — -PL. it A SETHE i i POA 01 HLA-DRRA } ï v x INI ANA ENT HILA-L i ! - : IVAN 04:01 1 } Lans es i ASO OR B1 i : 93 97 DRAN PORE : i _ { i ACY 0 _ ue i SRE TON ANNE LL — -

A ir TES - SEAN Le a = ; [ ee PA at PAT A A FN . 0 +5 { WER ORA ir TES - SEAN Le a = ; [ ee PA at PAT A A FN . 0 +5 { WHO OR

Sa. NERA NE HE ALTA 04-0530Sat. BLACK NEXT TO HIGH 04-0530

KRAUT N HLADPAY orKRAUT N HLADPAY or

X X meen TNT der 3 ax AL 5 : A 3 CYS NIH yo UU , a _X

CU ADP A ALERT I oo = = 5 ? . _ i} NY AH AUT \ i RR 02 01 ; = Ni VS ACNIDA 4 CTONDPR # 2 | BADEN At an : a 5 ; 2 3 = - va O40 = a x N XCU ADP A ALERT I oo = = 5 ? . _ i} NY AH AUT \ i RR 02 01 ; = Ni VS ACNIDA 4 CTONDPR #2 | BADEN At an: a 5; 2 3 = - va O40 = a x N X

Lu ; | erro TAI A MS A +} ALDH 1 ; : | 2 _ RDA RR TNT AD i 4 * O4 di HELu ; | erro TAI A MS A +} ALDH 1 ; : | 2 _ RDA RR TNT AD i 4 * O4 di HE

Lu TOUR T DAS ad M4 2Lu TOUR T DAS ad M4 2

TTT Pond À HY ad IN DSTTT Pond À HY ad IN DS

TT LHLA-DPAT I aa ON TAG _ a : ca RNA EN Se 9 | 31 KT SNS 2 X x N 1 Qi 0TT LHLA-DPAT I aa ON TAG _ a : ca RNA EN Se 9 | 31 KT SNS 2 X x N 1 Qi 0

FT 8 À ë | : CNET AA SE à : § DE £2 N 0 oe i PP AUGEN ’ ke Qt a — a gen On AN a fo YENI A Ry a 0 > a : GAT FEO AYR 13:02 aFT 8 À ë | : CNET AA SE à : § DE £2 N 0 oe i PP EYEN ’ ke Qt a — a gen On AN a fo YENI A Ry a 0 > a : GAT FEO AYR 13:02 a

EY WI AR OU HAEEY WE ARE OUR

TT | HLADGATOT OUT a 5545. L HILA-LIRAT TheTT | HLADGATOT OUT a 5545. L HILA-LIRAT The

AA | DA 43 Daa oe 1 Vis Fe En — 1 NI i an - + N i = [5 an ton oo 5AA | DA 43 Daa oe 1 Vis Fe En — 1 NI i an - + N i = [5 an ton oo 5

RAR {0 0 | oo nn - CETUS THD SAP nARAR {0 0 | oo nn - CETUS THD SAP nA

TTY A DREANT 01 aTTY A DREANT 01 a

TERE Por ALIEN 0TERRE Por ALIEN 0

RE { 18.23 pov Les - 2 pen NN A IS FRANS NS 5 SSRE { 18.23 pov Les - 2 pen NN A IS FRANS NS 5 SS

Lo TR TNA LENS TNS {5 + =; +3. 0% 0 i CE a 2 À HN 4 ANS S10Lo TR TNA LENS TNS {5 + =; +3. 0% 0 i CE a 2 À HN 4 ANS S10

I meme T NY AA [SS SEL LL yO : HLA-DOATOS O1 LLI meme T NY AA [SS SEL LL yO : HLA-DOATOS O1 LL

TURE OEL LAUT HeeTURE OEL LAUT Hee

Ua boom AT F1 HAT —Ua boom AT F1 HAT —

M7 + 2043 DRE ee aes i db eeM7 + 2043 DRE ee aes i db ee

X aa ; oo 1 x Lecce Ë a f CU Vee a } RA& PN ; 0 uX aa ; oo 1 x Lecce Ë a f CU Vee a } RA&PN; 0 and

LOB PU i =LOB PU i =

Poa i QT m 8 } X aaa Ë co mem Po I -Poa i QT m 8 } X aaa Ë co mem Po I -

Taam LA I —Taam LA I —

A HE i Co oo : 5 Pen Te ES PEN 4 bit AA HE i Co oo : 5 Pen Te ES PEN 4 bit A

CES A AS vy UD As Ÿ 20 1 HLA oo | CT ALND A ARTS NVR HRI ;CES A AS vy UD As Ÿ 20 1 HLA oo | CT ALND A ARTS NVR HRI ;

AT » TRAPATT BE AUSSER A 01030 5 ne | ! CSE AN NS EDR AMV ANS HEADER AA al i VALINE AAR RASS P3400 HHL =AT » TRAPATT BE EXCEPT A 01030 5 ne | ! CSE AN NS EDR AMV ANS HEADER AA al i VALINE AAR RASS P3400 HHL =

CCE DPATTOT Uh LATE = Tad WY A vA : 1 HLA OT ODER 2 wer TS DPATOS-CUDPRT04CCE DPATTOT Uh LATE = Tad WY A vA : 1 HLA OT OR 2 who TS DPATOS-CUDPRT04

Li n OT HLAHPATOS OUVDI LeLi n OT HLAHPATOS OUVDI Le

HY PRTOTOS MLADPAY ER we a VOS OUDPRUOTS PL: a = oo & SE ; DOSE AUT AL A us nn Sn 55 = [ a 86 © | DPFAT Lil AL BAAR i se ï MAE og ; mmm IL x 10 OB - - LORRY 4 01 HLA-DOATOSTHY PRTOTOS MLADPAY ER we a VOS OUDPRUOTS PL: a = oo &SE; DOSE AUT AL A from nn Sn 55 = [ a 86 © | DPFAT Lil AL BAAR i se ï MAE og ; mmm IL x 10 OB - - LORRY 4 01 HLA-DOATOST

ARENA TVET AA A x WA CE i i messes FOIE HA Sry VUE REY ai A [ | THAD Padi: D 3 ; i 3 DB Ï DEN 1 ee - ; < ; © . | CA rate A SHS-OUDOR 30 a | 7 - - i Le. AT A oa Si 1 4 iD GRY a me SZ VU ACT ARMA VO :ARENA TVET AA A x WA CE i i messes FOIE HA Sry VUE REY ai A [ | THAD Padi: D 3 ; i 3 DB Ï DEN 1 ee - ; < ; © . | CA rate A SHS-OUDOR 30 a | 7 - - i Le. AT A oa Si 1 4 iD GRY a me SZ VU ACT ARMA VO :

Toma y à : LMHS RAR HLA-DO,Toma y à: LMHS RAR HLA-DO,

RATS i : DY? Li AI \RE1*13:02,RATS i : DY? Li AI \RE1*13:02,

Mie i Dass 02.02, HLA-DRE So me G1 HLADRETGS 07 peMie i Dass 02.02, HLA-DRE So me G1 HLADRETGS 07 pe

I - ETOSOT HLAURET a or PUR Aa AS i HLA LLI - ETOSOT HLAURET a or PUR Aa AS i HLA LL

PTE © id} AIRES À GOT CE a i ORB 4 À 11 +4 Lt LAr Co a = = ha TTR ATTIRE SRA 50 HL : _—_ SNS E EN ENS il VAD R = HEPTE © id} AIRES À GOT CE a i ORB 4 À 11 +4 Lt LAr Co a = = ha TTR ATTIRE SRA 50 HL : _—_ SNS E EN ENS il VAD R = HE

SOR OT MALT REAOT 01 HAT ; DES TRE NT HL AU RB107. 01, "TO ASS ADS 07 HLADR pr NS I 31 Pol ooSOR OT MALT REAOT 01 HAT ; DES TRE NT HL AU RB107. 01, "TO ASS ADS 07 HLADR pr NS I 31 Pol oo

RA42 ï x HE AO nn _RA42 ï x HE AO nn _

NN X H ‚m x ~ AS STIS }e AE 0 8NN X H 'm x ~ AS STIS }e AE 0 8

Eh | DPATH 20 VUPDT IA SE cs pus | DFPATDES SE ; se A “ AS A Ron ANA 3 HADI aEh | DPATH 20 VUPDT IA SE cs pus | DFPATDES SE ; se A “ AS A Ron ANA 3 HADI a

DENIS NS LA IRR 07:01, HEDENIS NS LA IRR 07:01, HE

CURE RRA IYZ HEADRREBYCURE RRA IYZ HEADRREBY

CE RL ADRE TS 07 HLCE RL ADRE TS 07 HL

A | HLA-ORA 108.07,A | HLA-ORA 108.07,

Mis 124 AAA I 6 © | Ë SPA 4 A { vi 0 . a hil 4233 | DPA4 FOSOUV/DPRITIAC rm ce - J NTA A SE 1 HL ANIPA4TD VOSADE _ ; Da AN 274 01 a AU ; N a ; yA TRV Ma H LAL EUMis 124 AAA I 6 © | Ë SPA 4 A { vi 0 . a hil 4233 | DPA4 FOSOUV/DPRITIAC rm ce - J NTA A SE 1 HL ANIPA4TD VOSADE _ ; Since AN 274 01 a AU ; N/a ; yA TRV Ma H LAL EU

UHR SOTOUTDION DOSE} EL . _ 2 Sn 2 - RUE NEN SED DAN OùWATCH SOTOUTDION CAN} EL . _ 2 Sn 2 - RUE NEN SED DAN Où

La at a. Pan 7 AN AN TNE 24 OR bial Mai es EAA MEA MDA TOTONDPR N : | | : nn RN SE DAN a Fa -“ 54 i AnD PAG ) SALa at a. Pan 7 AN AN TNE 24 OR bial Mai es EAA MEA MDA TOTONDPR N : | | : nn RN SE DAN a Fa -“ 54 i And PAG ) SA

Le | EUR à RE IST EA A OD , SELe | EUR à RE IS EA A OD , SE

M TH A-DPATOTONDPE on ; 5 | HLA-DPATOT OS HAANM TH A-DPATOTONDPE on ; 5 | HLA-DPATOT OS HAAN

HE TESTE TL ALI ue - hada | A0 7H GAPE —HE TEST TL ALI ue - hada | A0 7H GAPE —

PAIS | 59 75 i ATA = — nn N | TT A AI EAN y > 0PAIS | 59 75 i ATA = — nn N | TT A AI EAN y > 0

TTT i iA ot bat at US 0TTT i iA ot bat at US 0

CE PAD aU 0CE PAD aU 0

HF To PILAR 0 :HF To PILAR 0 :

Ta rd x i 2 —Ta rd x i 2 —

LARA in i $020 — ’ i { ’ x een. ee TTLARA in i $020 — ’ i { ’ x een. ee TT

HN - A BE TENT TE für > £ x > 0HN - A BE TENT TE for > £ x > 0

TT : NIE EM o ; TT H'ADRES0RTT : NIE EM o ; TT H'ADRES0R

PE POLLENPE POLLEN

CN aa RS NO Ë 8CN aa RS NO Ë 8

RS | i : SR i i tanmeldune ische PalentanmaldungRS | i : SR i i tanmelden ische Palentanmaldung

Luxemburaische PatLuxembourg Pat

AVRAVR

28 99 5579 28.07 7073 : EAN28 99 5579 28.07 7073 : EAN

PTPT

PMCE GmbHPMCE GmbH

PMCR Gm ue 1C-0005S-P-LUZ)PMCR Gm ue 1C-0005S-P-LUZ)

PMC-OC0S-PLU aPMC-OC0S-PLU a

PRIC-GC0S-1 {PRIC-GC0S-1 {

2°2°

De nmDe nm

Gt RAA LANTA nîides KAT-ATTRGt RAA LANTA nîides KAT-ATTR

Hi the peptides Wh WO,Hi the peptides Wh WO,

Ï pertiss of the peptides AMT naical oranerties of the © walimmunological or dhertiss © $Ï pertiss of the peptides AMT naical oranerties of the © walimmunological or dhertiss © $

SN hemigal/Änımur ARRAY Le ÏSN hemigal/Änımur ARRAY Le Ï

Fable E5-3: BlochamicalfimmunologFable E5-3: Blochamicalfimmunolog

TTT | Anti genTTT | Antigen

TT ; N ANNE ïTT ; N ANNE ï

TTT ! LAS » iTTT ! LAS » i

TTT | X x gen | i | HF SR = {TTT | X x gen | i | HF SR = {

Alle | | $ ; Vaxier wo | et | ; $ | ang ! SENSE En { ee : A ! = TO = H | = i oo +. ar | S Nn OQ : Ve 3 | > ©All | | $ ; Vaxier where | et | ; $| ang! SENSE En { ee : A! = TO = H | = i oo +. ar | S Nn OQ : Ve 3 | > ©

No jE | Biast i start | preNo jE | Biast i start | pre

ENTS ï | a : | SONT ; ' | _ENTS ï | a : | SONT ; ' | _

NS | LT i | | poNS | LT i | | po

Po | 1A EN | i A — -Po | 1A EN | i A — -

BE 14409 | 49358 POBE 14409 | 49358 PO

Tam | an x ot TN A | 122.00 : | ee] w+ ok 0.4 PAS | EaTam | to x ot TN A | 122.00: | ee] w+ ok 0.4 PAS | Ea

TTT POA Pu i | ue ei ie +4 POA i 1 Lu :TTT POA Pu i | ue ei ie +4 POA i 1 Lu :

Lu an a pT CER : | TTT | anna 15.90Lu an a pT CER : | TTT | Anna 15.90

ML a CUT Va 084 - = uN | i ~~ : SAN Po FOE | 'ML a CUT Va 084 - = uN | i ~~ : SAN Po FOE | '

Lu | | ; SR 1 A < 1) | 1913 _ nn“ | Ba Lan | 4492 4 LTLu | | ; SR 1 A < 1) | 1913 _ nn” | Ba Lan | 4492 4 LT

TTT POG [EA : TT | SnTTT POG [EA : TT | Sn

NE | PAN X . i | ET _ = pes Ÿ tu LL } i mmm mans PTE RESNE | PANX. i | ET _ = pes Ÿ tu LL } i mmm mans PTE RES

MS Jo VII Ven ln 49 03MS Jo VII Ven ln 49 03

A N ; mr i § a RTA bo 4 Le a ; 7.40 hen | fro 7 aa 14H77 8 Ï 1196A N ; mr i § a RTA bo 4 Le a ; 7.40 hen | fro 7 aa 14H77 8 Ï 1196

M4 Ë 2 i x | : = rn his - - =. Fe i PAR FOS . : a | rare YY { © A + iG. AR - = | Ë pra m x QF 7 | BAT | IM4 Ë 2 i x | : = rn his - - =. Fe i PAR FOS . : a | rare YY { © A + iG. AR - = | Ë pra m x QF 7 | BAT | I

F TTY | Lan FORA | AT.F TTY | Lan FORA | AT.

TTT Pn boa) fi | QT | ) …TTT Pn boa) fi | QT | ) …

J | HA Po : i ee] rs = | | _ | i JTS X Fa SA | 0 07 ; : x - JETTA { ONE 1086J | HA Po : i ee] rs = | | _ | i JTS X Fa SA | 0 07 ; : x - JETTA { ONE 1086

Las | ed 2a} : 4 a | 205 | 2 roc : 170 100 Ë | Bsa RagLas | ed 2a} : 4 a | 205 | 2 roc: 170 100 Ë | Bsa Rag

Lu pu COST EE | AQA Pod 108 en - mn tan x { os4 : 3Lu pu COST EE | AQA Pod 108 en - mn tan x { os4 : 3

Lau : CUP | A : 0 / i | 854 | | RALau : CUP | A : 0 / i | 854 | | R.A

OP i 1/0 LD Li Te 2OP i 1/0 LD Li Te 2

FN PN to i Le _ Len = # | fe - : Homer La } + N + | 205 © - | Treo i ONY | ar HEE ! {AA - | i Paar | 4035 N bd : cou Dan | 4023 E | Rn 2 | Le Here town Li AA | 087 sl | rates = HR oanFN PN to i Le _ Len = # | fe - : Homer La } + N + | 205 © - | Treo i ONY | ar HEE! {AA - | i pair | 4035 N bd : cou Dan | 4023 E | Rn 2 | Le Here town Li AA | 087 sl | rates = HR oan

A | Ë pm x so | TR : | CO]A | Ë pm x so | TR : | CO]

Tm Paya : 9 | | alTm Paya : 9 | | al

FE i 0 + 198) Pont | 0FE i 0 + 198) Pont | 0

FY POG 155 ibe osFY POG 155 ibe os

Lk | | Lo ; cop LA AS 1027Lk | | Lo ; cop LA AS 1027

Le | Ë EE | > x as 1037 ll | | i fi” i en oy } YT 08 an | | ; in ae 93 ta | _ » | ; CCE A An ON 793 | | jesLe | Ë EE | > x as 1037 ll | | i fi” i en oy } YT 08 an | | ; in ae 93 ta | _ » | ; CCE A An ON 793 | | jes

PES 10686 PAL i Ra iePES 10686 PAL i Ra ie

NOT | | VOS | i a a wr : | | PT yo so Fu à O4NOT | | VOS | i a a wr : | | PT yo so Fu à O4

QE roro fr Ue Favs = | | ETT Ds 5 : À ER | 172 | fnQE roro fr Ue Favs = | | ETT Ds 5 : À ER | 172 | fn

Frog ; INRA 1 47 1 155 | | 200077frog ; INRA 1 47 1 155 | | 200077

JET VO 85 31,3 Ss Li ull | . | re i aN enemy LATIN 08 a. | an 407 | 4070 | N + | | CE 4 . 100 : 4007 | | earJET VO 85 31.3 Ss Li ull | . | re i aN enemy LATIN 08 a. | to 407 | 4070 | N+ | | CE4. 100:4007 | | ear

TUT : VAN OS 100 i 10 Lo a | PULSE PU i ir hanTUT: VAN OS 100 i 10 Lo a | PULSE PU i ir han

SIT | 44 PALS | ; I ER . | - | Ë a ee “ „x 4 <3 7 | 203 | 3SIT | 44 PALS | ; I HE . | - | Ë a ee “ “x 4 <3 7 | 203 | 3

UOTE | na 5 | 487 | | BRS fou i 4/0 | 33.3 | IAL.UOTE | na 5 | 487 | | BRS fou i 4/0 | 33.3 | IAL.

PUR i EY 497 t 205 | iPUR i EY 497 t 205 | i

RC | i 1 | - [ = — Va a i | | CeRC | i 1 | - [ = — Va a i | | Ce

PRE i 4/0 1286 i | LT i RTS | on Ne x Ia & i ooPRE i 4/0 1286 i | LT i RTS | on Ne x Ia & i oo

N { | NO PMN } | a or -N { | NO PMN } | a or -

ARTE | ++ | NU i | TE | a.ARTE | ++ | NU i | TE | a.

ART 1 A Ï + mmm + FT niART 1 A Ï + mmm + FT ni

OU i 10 215 i | nnOU i 10 215 i | nn

A17 Lat | le = vus i 3 i Go .A17 Lat | le = vus i 3 i Go .

À À à or po x i eh | EmÀ À à or po x i eh | Em

Eran | No 1 AU | QTEran | No 1 AU | QT

RATE er No oi ory ly i | LT i i I dGUESS er No oi ory ly i | LT i i I d

L AL A

A ische Patentanme dungA patent application

Luxemburgische PaientarnLuxembourgish Paientarn

LUXSIMOUTUTISCHELUXSIMOUTUTICAL

; 28.02 7023; 28.02 7023

Ks N NEKs N NE

PMCR GmbHPMCR GmbH

PAMO-O00S-PULUFZ)PAMO-O00S-PULUFZ)

PRIC-GCOS-P-LU(ZIPRIC-GCOS-P-LU(ZI

Claims

SS ER mia SEES 4 A EIQ a a seas pi $ - is £. a; & 3 qi { &; “2 1 A PRSSSMASMIiS ai Samimaaitias far aa aa à machisarmant In aartiecaliar Far ea in dha A PRArTACSUTICA! Composition 107 USE as a maaamani, NM DarticUIar TOT USS mma BR oN FON EN ONG EE EAS EE pp pe Van nd yon bases sui pes at re En æ -, cafe + In FE din en 1e à ie es iy fhorananvie aranhviaotie frastmant af a carmnavirns infastinne Aieesca In nartisidsrin a UST ADELTIC OF DIODITHIEGUC Ha diimaiil OT a COTONSVITUS INTGCHOUS QISSESES, in panicigrn a & SHiNANS Ar Aranın AT euinentie anffarine fn Ar at rich of Sfferis frst a ears aire > SUDISGI OF Group OF SUDJGCIS SUNSDING wom OT SK OF SUTTSING TOM 8 COONEVITUS isfantinuie Aicsases SET EIS Im NIECUQUS OISSaS®, Compnsing a aharmasaiaaicaiiy affactive aman? cangiating oF at jaaaet 1 artisan nnlvnantite & PharMacOiOQiICany SITSCUHVS amount CONSISUNG OT Al 168381 1 amigan DONDSDUOS CRM IAMS SAMNrIEIRA af tance ang MME ALA andinr Mi ALR anfisan neantinms urkarsin tha Ss a = & = AS & Se = eH + x 3 aay = IND AFSTATOITT FE SSQUSNCE COM ISIG aU IgE ONE MLA-A Gili On PILAOE aiigen RPeiag, wharam INS ws LA A aaa cond bed 3 ; & à i ; Lt: çà 1 JH SNS ya lan earraonsameis te a eye ARS Say MSN RAY FENN in hm iu MLA antige” DEP COTTOSDONGS 10 al 12880 ONG SITHNO 8010 Séquence N ne rires spi u D4 4: Sa ; ; sa ; ; PV PNA FEY oO pra ee En GS as ane at uv ANN SNS FAN ee 2 Ni aaa laa ENE 2 NT cent INITIAL as ¥ Ss & mraix ST Sarna nissan a Bereta ANNE COTONAVITUS, SUCH 85 SDIKS oi domain, Dé GOMEIMN, NUCISOCADSIG SPOLEM , SMNVSIODS en ee aes ir PRESSE A A 8 8 des seen aa Zr DIRE Tah eye hy EN DTOTENT andor VRP TaD DONDPFOISINL, Sharaotarizasd in that LAO SRL AAO BARNEY DNS OMITSRR +R 12 the anfinen NEE I I easnanne SA reas the Selene SHSAfTAIe arming Sein cannianse His 9 aR = ra sa = ae eas that a: gent ar anid Setianse TE SS DONDSLDUGS SSQUENCE SOMOMNSSS INS TONOWING CaN amine adil sequence! Fa) à [nan mantinde 15 os eon ime aAanaherant Ar Anlunantinle TT N AN VA fol m z anti Oo © sn i pe FEE ? a = une RATER thao NY ERY ON SNES {3} à ONG poptde, LE, à COMDOUNS, CONSIUCI, OF DOIVREDURE, Wwharamn Ing amma add HN AN TN SN EN ES Ya N NN TA EN 5 LA NN NEN RR ns SSP A BY AAN © oad yaad ge SON IANCD NE eh amt aa ang bd antinan nantiaa sar dt ALR antinan mantissa ac SAALE UT woh CRM SOS UNE POISON ARTS VENUS OF MLA EN béebptide as ey ff ond Do set soe Fam o Cn . Co Ce TE de ie UN . MY Aafinarn harain wharain Ha ming Seid cam anes camaricas IN asain fn tha BALA ZU GeHNed Narain, wnerain Ing amine SCHE sequence compnsas, in aGdiion 10 INS MLA- A antisan nantirle ar Li AU antinan nonfisde tm tn 4 fa N arming acide andiar ANUGan SSEDUUS OF MLA antigen Depuas, UD 10 1 10 QU aiming alias, andidy FAN ey er ies Ber wide à site b ~ LA 0 Lam at & le ai N Is 43 i [=] FY à olmilariu nantide 15 a eamanand canatriet ar nalunantiie wharain tha amina asin {9} à SIMHSTRY DEDUGS, LE, à COMSOUNG, CONSIUCL OF DPOYDENUCE, WHarain ing aiming ACIC NANT NaN ON oh en eed tart Ted few a od a ST a ne 1 A PNA sane EAN vere en ston day Be oe NA A N N on en ond edo sannanen of whieh ie ne Safran in fem Sal ar (AN wwharain fhe MALS antivains neantiste SSQUENSS OF WHICH IS 88 GETS AT jam (a) OF (0), Whargin ing MiA-A anugan papas ar LE) A DEY een A ener od on Shen on sd à ten à 3 New +i A AOL in is AF bd} AS antinan nardistda as dafineor! haraix Rauinn lance than 100084 aannonse iNantibe OF PHA antigen DODGE as GENE” Narain NAVING 888 man TOUNS SOQUENCE CGTELV sa ue aie beater 4 Éle he Qi] A isa dus bp pas id Saal ; cris oo i DENF si nr eimilarite 4m tha native WI À antinan nantidNea ciel as havinn af lanet 055 PY EQ QF SITES 10 INe Native PILA antigen peplida, SUCH as naviig at Past Sp, more ve Fen ni nd X «AO Led ga STE ii nrafacaniihy ot aaa GHG SAN IANO VASEN ansiinagy PraTaramy ST 19781 Wide, SEQUENCE KISMTIIy, Ari OI fo) a cheri nanticda Ta a PANNE SAANSTITEST aahunantina wiharainy tha amiins {CG} à SUDSIRUTION DODTIGS, LE., a COMPOUNG, CONSTLCT, OT S, WNSTSH INS amine mans een Sn gre ent aha Tan ES 8 N x Ia Faut FA i x A} N A A : DST SOS DITS ar whieh in as Nate in Tam fa ove fim waranty he Lei ALS SANS IN A ACT SSQUENCE OF WHICH IS a8 Qoinad IN KOM (A OF 16), WASTSIN Ing MLA-A angen nanticda ar NT AR antisen nantida as Nafina harain havinn an arming anid camianes MRERUUGE WE IRD CRT TLIRGOSTE TROND Qo WEIS PITH DÉCRVIIILE an Qin id alia SÉQUENLE ren TR te ett © ; ; a eat at ét Le ax ag PARTNERS ar SSSR ascantiaihs af AS ana saving acid! quhotiidinn radiated in the SU COMPISInG OF CONSISNNG aasanmiany OT Only ang amino atid SUDSTRULION TSIZUVE 10 ne ENN EEN eNO aN D a anh Fa 4 a m5 Er aang Lis À FLN me a $F - SAN acid camiianss af the native di À antinan nantes ansine QING acid SSQUETICS OF INS Nava MLA anugan pede; angidt PMOR GmbH DRACONIS DE ie BA AD N02 Drees sadn ees ee en Da en beth fait SAND HSL EAN Luxemburgische Palentanmaldung

{hh a tandem peptide, wherein the amino acid sequence of which is as defined in Hem (a), COMDriSING ar consistina of at least 7 identical or different MLACA and/or HLAGE antinan ASTI FOI IY VI LATTER I GT QL SOL A, AUTH UF WHET GT D TRS NUS df il RL SNe peptide sequences, both as defined in items {a to (0); and/or the amino acid sequence of which is as defined in tem (a), comprising or consisting of at east 2 identical or different HLA-A and/or HLA-S antigen peptide sequences, both their amino acid sequence.

3. The pharmaceutical composition according to claim 1 or 2, wherein the HLA-A and/or HLA- 4 The pharmaceutical composition of any ons of the claims 1 to 3, wherein the antigen polypeptide Is an amine acid sequence selected from Ihe group consisting of SEQ ID NOs

5. The pharmaceutical composition of any ons of the claims 110 4, further comprising at least one amino acid sequence comprising or consisting of an HLA-A or HLA-S antigen peplide, COTONAVITUS, such as spike S1 and 32 domain, nuclescapsid protein, envelope protein au a Pie PNR IR ES SN aN 2 a! N PTE EY OD A De A = Pree N = +5 alas “ Son & Nem a itty ue +5 8 The pharmaceutical composition of any one of the claims 1 to 5, wherein the pharmaceutical composition comprises at least two antigen polvpeptides, wherein the FMCR GmbH PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung ne QE 53 8 1e $ ts of the coronavirus entione selected from the spike 91 i mbination of different parts of the coronavirus epitope selected from the spike 57 D & CONDINATION OF diTorent pay NS CUTUNTAVIEUS IQR Se Ë 1D à CONDINATION OF Taran DANS OT INS COTONE i 5 &; u NE cde pen en Ù os send eng ay € ani t a srevbanin anne OEE al nolcnrnstais Ç ; ; sid protein envelopes nrotein andor ORF Tab polvorotein, i SE domain, nucleocapsid profein, envelopes Di FLINT QIAN WSR LO NS Ni Ley ee 829 fines sia ROIS SUSE OY ISHN, Ovens DNTOTENT STELLET { Yi SOMAENT, od oman, DULICU LAN SRE prising, X } € ti teat 4 te © ohren dha u © ane of the claims 1 to & whereby ihe . ; Cot mnosiion of any one of fhe claims 1 to 8 wherein ihe

7. The ghanmaceutical compasiion of any one of the claims 1 to 3,

i. PNY Qharmacoutical SOMDOSTION LT SH $s bec i x i Ted SRE : ç Haar accantahla sarrier Baad ans a : ; say. norises a pharmaceutically accenishie carrier Hould ang a i aoaulical composition comprisss a phamacsutically acceptedabie carrier il JUHA af © DHArMactSutiCa! COMPOSITION SOMDMSSS à DHAINTACSUTICAINY a $3 3 NAME CONMSOSTEON COMPS i 3 o , 2; Lt dental i 3 Ay lient mar av heat! tioaitv accsptiable adiuvant carrier diluant an FOI QAI, mn Fe aie aig SANE EN SL HE SA SITE NCAT NITY OMA ESTONIA SAGE ik DhArITISCOUTICENTY ACLENRNE JQUval, GEN, ry : bei Fone than tien : Fhe HRrananina pisime far tha sie ' A sat HN TN any ane of the niracoanting olaby 3 for the use ë Th HCE COMPOSITION SCCOrGING 10 any ang ring producing CISITS TOI ing us 3 The pharmaceutical composition according to any one of the precedin 4% 3, ine prarmacaiiiica COMPOSITION SIEGTE y | & 43 1 u N ehr i + + Heal composition is anafed subcutansoushy Le tek Dei ahérain the shar ana bios SOMDOSITION IS annua SUDCUIANSOUSIV, set forth in claim 1, wherein Ihe Pharmaceutical composition is aided § 3 S81 TORN HT Ci on 1, whnsrain INS SANS S en 3 Tad ; 3 o Tend rere dan revs sa dis Af ind eu ach or indradarmaiiy io HHFEMUSCLISFN of mraqdamany. : = 3 ied archiart ie à Mises i 38 Yan to claim & wherain said suhlanft is à human a ue SOA SANS AN accarding ta elaim 8 whharain said subisct ig a human, a The pharmaceutical composition accordina to claim 8 wherein said au i Hoong MENGES COMPOSHION aoirang 1: ta ©) Saar Bein bn then € 1 Hao to claims | to 9 for the use set forth in claim 1 0 2 Hem] SEE Rao iia; sennrnina in claims Tin 8 for the use set forth in claim i The pharmaceutical composition according to claims 1 to 8 for the use set 10, The pharmaceutical COTADOSHION SLOT KE ÿ 3 Eau an oe BALES ir 3 x Aantinas SNrrachanaines te RAN } i {5 i € eier antinan DOVDENTHOSS COTTESDONOINS to Write 5 $ 5 N HEA antinan aantıdas andllar antinar ON NSVUGES COITESONOING 10 WM IN yhersin the MLA antigen paptigdss ANAT antigen KRONE LOT i iY re WHATS ITS MLA antigen DODUGES anya : U fA a ; \ + € RARE AT an i { ver pentidus determined by masns of an A so immunoenic antisen nentides lsterminedd dy means of an 2 | comoplaxes are immunogenic antinan ne ALLIED, MSIGTTRIEU WY hea class | complexes are immunogenic antigen peptides, and LIESS 1 COMDIOXSS ait anmunogonic amiy PE: Haan vd As of \Alseftarn Rist 5 $3 i 0X + st Henn de Bu means oF Wiaatars ie ES Ayılar fit ned Hmin de DV MSEANS OT VVêèsiern mo

. ç Satis RSC 7 5 HNarÉipiiiss fist nnd vite Oy y means al vVveste , HIIMNTUNSOOanionyg a au i Day hss Tn WR GEL GAY HIVTIUHOGSMCHY assay, IN paiiduar {ut Not ; 3 tT pe = + ELISA techn AU ; ; EUSCIFOCHESMALINTEHNSSCEMT immunoassay {TE 3 i RAC; SA MS STI With misrsssanis ansalveaie RAS ar immnnacdatastinmn with ri HWOSCODIS analysis, MO OF HTEMUNGGSISCHON win MICIOSCODIC anan “ey > LA 8 uni ta 90) Fr the sien sat i ti $ ne of claims 1 to 10 for the use sai ; ; eal sösition according to any one of claims 1 to 10 for the uss set A TN a gen En a 0° PRA ANI NT aN € Ta Te) ANE Sri Ÿ > any ans of claims i to 10 fo | = PH 08 DPHAITIACEUTICAI COMDOSHION adoarging 10 any I TRS GRAIN i ii sie dise Li A DY se à a Hi: AA nnfinen nentide andar Li ALR os . à Eat. wrising at least one HLA-À antigen nentide and/or HLA-R Pa oy en deniowy À Farther oamnrising at east ong MI AF CHUA Y BATRA LNT al drs forth in claim 1, further comprising at least one HLA-A an 3 PE FORT NT GRAIN of, TUNner COmMPnomg a 18a ; 4 TE LA KALI siscee | snminlavae antigen peptides corresponding to MMS class | complexes. antider EDS DON SEALY ENGE LAS SEE A AED ON KNOW antigen Qapiaes COrasponamng 10 vii Cie i > MR : si + © faisime 1 de 141 far dha sea ne sat . 34: srr iY PA SRY Ana oF sisim 1 +, for the use as set 12 Th i gical composition according to any one of claims POISE DORA ADI LINE or ot

12. The pharmaceutical composition acc ENG IQ div Ong OF Gioittis | 10 a! LS PENS PNarmaceiiical COMDONTON SCCOrGMNQ 3 : 3 ' i: hada ran on § 1 ns fs the reenechume anihiune i try $$ Tien aoivnantinas earrasnanading In tha ragnactive SU DVDS tet VR] gherein the antinan noalvnantids COTES NGING 10 ING lESPECUVE SUDIVDS forth mn claim 1 , wherein the antigen polvpsplids CETEPONGING AU i i Yi MARI IT GONE 1, WRIT VS GNU à CR $ © 2 à ; 5 £ 3 se anaiaiinn nf the aminn ani ï ï to Tam the aroun cnnailatinn of the ar HRD acid x MHC class | Complexes are sélecisd from the group consisting of the amine acid pi the MHOC class | complexes are selected from the group LUSIRUNY U of the MHC class | COMPIEXEs arg SEISCIEN TOM I A U SEAN EN AN A 58 or have at least ong amino acid substitution forth in SEQ ID NOs. 1 D9 OF NAVE AT IAS Ong aming said SUDSUTUTION SSQUENCES SSI oN IM Sl Hd NOS, T~ 58 oF Dave al isa ong ami SSEQUENCES SET TON HT Smid IL NUS, set tin ihace aminn asi canannas with respect to these amına acid SSAUSTICAS. WHE lESDEOCI 10 TTGSS ving agg SET Ar GU PMCR OmbH 3 EMILY Rane 38 99 720923 Luxembourg Patantanmaidung PRIC-GCOS-P-LU(ZI 28.02 2323 U FORO AR

13. The pharmaceutical composition according to any one of the preceding claims for use as recited in claim 1, wherein the pharmacologically effective amount of sach individual antigen polypeptide in the composition is in an absolute concentration (Le, administration et 14, The pharmaceutical composition according fo any one of the preceding claims for the use set forth in the claim, wherein the pharmaceutical composition is administered as prophylaxis or a first-line therapy to the subjects or group of subjects having at least one identical HLA allele, therapeutic or prophylactic treatment of à coronavirus infectious diseases or for a preferably is identfical to at least one amine acid sequence in the coronavirus, such as spike S1 and 82 domain, nuclescansid protein, envelope nrofein and/or ORF ab polvorotain S21 ANG Dé VOTENT, TGS UGGVORNT FISH, CHI TIQUE rls GIVE Wn Tally VOIS NEGIONT sequence of which comprises ong HLA-A antigen peptide or HLA-B antigen peptide as defined in; the amine acid sequence furlher comprises up to 1 io 30 amino acids; andfor or HLA-S antigen peptide as defined in having less than 190% sequence identity preferably at least 90%, sequence identity, and/or {c} a substitution peptide, LE, à compound, construct, or polypeptide, wherein the amino acid sequence of which Is as defined in Hem (2) or (5), wherein the HLA-A antigen comprising or consisting essentially of only one amino acid substitution relative to the FMCR GmbH PRIC-GCOS-P-LU(ZI 28.02 2023 Luxemburgische Palentanmaldung es Sf un : A x . : x [I] - SCH SOQUENCTE OT WICH IS as CONMSG IM nam (ar tent Dear = N ed YA Bin ue AA EE mu LA AA A ae LS A ES RS AE Amen ar eanaiatine at at lonet À identical ar ciffarent di AA ancdine LE AUS antinan COMPrISINGQ OF CONSISTING OF AT BES, KIM.

OF CHTOTENT MLA-A anor MLA antigen > 3 © ead Tad an ey yb un See Tem Ma BRNO AAN ee Aantins cannancas hath ne dafinad in Kama fal in (NV ancis PSDIIQE SSHUSNTSS, DOIN as Ganned HT tems (2) 10 (0) anit i ; eo AM x I Si prie à x 3 Fron an get ae ob qe À FR, "I € PR EEE Seen NE I Ha amine acid eanneancsa af which ie ae Safina in Kan fal PANNE ar Sansiatinn of 3 NS ain aia Sequence OT WHCH IS 95 Qanned M ROM (A), COmpnsing or consisting Of at innaet 7 iNantisat ar difarant WALA ander MAR antinan mania santipnhpes Rath ALISA J IGSNUCAI OF OHTSTONM MLA-A aniyor MLA-D antigen DSODUGS SSQUENSSS, DOI & Aatimnnnt is san Fea) de Fel is re DA fhe ond Lanot fan hdl À err love st mantisine ey sent ten in se defina in fame fa) ton Arm maw hich the at aaah hun HI À antinan nentinars arian 858 GETS IN Hams (AI 10 {0 IN WHICH Ig AT 12381 Iw MLA aniigen pepuaas ovenap in thaïr smina sein cesnienne WISH SNe acid sequanay, AN AR Tha sein ee es AS dal TS arian ren ie the anfinen ANA SA AN BAM { AS HA antinan ey hunde of cian TE Areas tha antinan nalvnant 2 SEN VIII a il 10, ENE angen SONDSPUGS OF CII 10, WISE UNS antigen DONDSDUOS SSQUENCE Qumpnsas Si Ban hun eh py men od op anes ey PAN AN EE ERY ey ha Ua QHAtEn amis as BASS INS TOHOWING SCATOIS SITENO SCI0 SSQUENCE: RER US SAR IND EN EN EY NS PTS FINAN et Ans ais AT NEN N ASS Sn at an et gn ben name d en od fa) an amian acid SANUANNE camming ar consisting of a gaming acid cennipnna calente {8} an aiving adi SSQUSNCS COmMprismng oF CONSISUNG OT an aming aad sagquency saiediag Foon aus 43 ary TI eh end pe FO IN Aie 792 ES nine Fram Th SSI oansishing of SOF 7 Ye Roam BR ans HOT ING Group Consisting oF DEL 1 NUS! 50 ~ Do any FRY an amis asia Serre hayınn aes than INNS san ansa inant sr ouviianites ta tha (D) AN STE SCH SUOUSTLS NaVING HESS Nah MMO SOQUENGS ION OF SITINSININV 10 Ing 4 nai AIN Se meat ey tn Hom fe ened ae af innet RR0 mnra nrafcrakies at AI SRI ANA SRFUIANSS SNe Is A Ham fa NET as at anct REM mara nratarahi à iQ aM SCH SSQUEMCSO aCCoraing 10 Ham (8), SUCH AS al 1088 057, MOTS praveradyy A ; à SNNOS en © con Seesen N N N Fan A ma ins AAN AA EA A MEN INN feast AN canancs idantiv (ae dafivan Maram is an amino acid cenneanne of SEO i RAS PUY, SSQUETCS SIE (85 GOS Narain} 10 an amino acti SSOQUEONCE OF old ILS Na 28 BR andar NOS: 35 — DE ANd/OI ' 3 Co aming SCH SEQUENCS, Ward Na SITHNO aid SSOQUENTS OF WINGM IS a8 Jama in té Ces tad nd Da on AA = on À oe Ca Sad aay abd iE EUR Waar fu SAMIANSING ar AANGISTiTY accantiathy oF Anh ANS aminn anis dala ian HEM (a), COMPNSIMG OF CONSISUNG ossaniiay OT Oy Ong amid ACIG SUDSITUTION on radiative ta th ANIA SNS sameness calastast Sram ha SNS collected of GEO IM > TIE te SR NS Sen Sag ane Ses DUT ES er ESS N RE EU FOHGHIVE TO ING SINE SEI SOQUENGSO(SZ SCHLUG TOM Ng Grud GOTSISUNIG OF SE ILS Ng 38 Of anddiar AUS] 35 — DL ANd/OI fe atantdeom neantins 19 SONMnAAUNN eonctaiel ar aalınantiaa SSURATSINS ar canaioting {QG } © TENCSN DONS, LE, à COMPOUNG, CONSIUET, OF DONDSDTSS COMPNSING OT Consisting AT at lana han iNontinal!l ar ifFarant nantina camianeas af at lonti ana SANTIQANDSS AS OF al 1938 IWO IGONtICai OF GNTSPSIN DODUGO SOQUENCES DT al 188s Ong SOQUGTNCE as Satinan in Fame al din fey but Gr whieh TRS ma SOUS camniancas are anfisnaiike CEHNSd HT TOMS (8) 10 (CI ADOYVS, I WNICH INS anne adil SEQUENCES arg gpuonany VE lean SA paph afhar hu audahiea Entrare fern salan ARNAaAnantimden\ analîne Abs ce a: ë = es are SALES DHONNANTITIES à ana ZS HITE TO SaCH OITET OY SUNSDIS HNKEIS (SU-CAISC CHOOPOPULES) to OVSTISDEIMG andam Pape compnsmy OT CONSISUNG OT EU Gas J, mora praferady + $ ba 5 q Lab ; i Eat LEP À A maniere Li AUS sea Sa rh Ee + Sieh Re at mast 4 rantisa! ar ciffarant bi 2 À anddiar WEAR antinan nantes >, SUCH a8 M GAS 4 emia OF CITG EM TILAA ar mas Antigen DODUdS NET à ae fac Hatines Maran ansnalines Ta ond Das Ras AE era LU AA eye feng LE A Saar AN fa Sei Aare séntirer Say oad Das trs Ni ya ME ALA = fear 41 A.

SEQUENCES (85 GONE.

NSTSIMY, encoaing TOF AT GAS WO, CITGTENT FILAOA SNOAOF FILA 5 antinen nentidae fac dafined horain\ wharain tha at inaet tas di À antinarn nantidas OF anugen DODNQSS (3s GSM Narain), wharam ma at 1038 IVO MLA amigan poptiges SA nanas RR a I He EA I a SANIANA A : AVATARS in Than am amie aasiian,s SU QVEnaR MEAN amine adi sequences PMOR Cini i RAL mde PRIC-GCOS-P-LU(ZI 28.02 2023 Luxembourg Palentanmaldung

De SE FF Tin vain AA nas NE a à NE le Baia HE nel AS raies +5 ex pri] s nnfumantiete 17 Tha antinan nalemaentids af any af ha ainime 15 and 18 wherain tha antisnan anlvnanticds tif. HO anugen DOIYRSDUGE OT any OT TS CIAIMS TD and 10, WNSfGNT INS angen SONDSDUGS LS AAA SAS SR Me A AA AAN BY 2CCorQancs with INS Gumanl WIVOIRMIONM IS an OVETISDEING DONDSDUGS proteramy cantainine hatıvaan Dia 10 mars nraferahiv containing hatwaan Dia S mast n refarahhe SOTNSUTHNG DEUWSSM £ 10 LU, MOSE DIETSTSIDIV GCOMMSMNENMG GSDASEN £10 &, MOST Prajerainy say fee es DS 8 oalifFerant ann aan aanniannes (AEA antisen year nase es ae Bay COMHEAINNG DOTWESTT A TL D ORTereiil GUTE RK SUITES (INILAESUTLIGESTE RapuQes) TEN a viral ANTANS eorrasnanamas ta ARN Claes | andar MRS Clase i poamniayves > VIEN RRR GOTESDOTHOHIQ TOONAMI ASS | other Mire LoaSS it COMIDILKXÉS. 49 Tha anfinan anivnantida of ant of tha nlaime 185.17 wharain tha antinen nalomaentive is TS, ENE angen DONDSDUOS OF any OF INS CIANTS 10-14, wharain ing anugen GONDSDUOS IS ome Bene pack gan ad NE 3% Ch IAN on ane NÉE - ar 3b NAN © aN SN nd ed ENA be anges es 4 = Ris € SES FES EN TN es snimevtmet Frais Tha fermen SAINTS oF TRS ann assis SSSR S oat Ferdi in QED I ANNE ssiected from the group consisting of the amino acid sequences set forth in SEQ ID NOs, an KA WI JE + iQ AD Tha SHÉiNOn NAlunantiste of ame ans of aime TR ia 19 far pen ao à madissmaeaunt In nartisider è SP se SEND a nt any ss ST a {RR} À Far em 2 NS mar in rat HE

17. ENE angen DONDSDUGS OF any Ong OT CIAINTIS 1010 TO TON USS 85 à medicament, in panics Fane es is dhe EE enr quête S$ any poy deo Van asdies Forums onda on end GW = ot gn we ANSE pes Aare end ian © an en an en gn Four pes in the tharanaatie awrooiheiaotie fraatmiant of a SNTANAUTTES INTOSTINUIS digoaascas TOF USS IN IN HISTADOQUTE or of QETIEACUE Troaumem OF & COTONAVITUS MTSCHOUS gissasas, whichrain the method comnrisina administering to the aubisct a fraatmeant reoimen including SE LIES TES TTI Ti I) CARO SIC DA ILE AIT DVI RATIO SU LTTE LIT POA IG ean TAG à vbr sr me hetero sm ny aan en NE She anfinen ives Riva pnd Eee a nharmapaianinat affantive avd of tha antinan sahantisda A Pnamacoiagicany SINSCUVS amount OT Ine angen poypapuas. am 15 AAS TT + pd ie u = se elas 15 tn TO that ara ImÄmuinnrnusanie in the satant ar EASE SR HI a DONDSDUGS GAY wane Wy CIs 1 10 1 nay art HINTILTIOGSGTHE MES patem Lh aroud of patients determined by an immunogenicity assav in particular by Weastam bint EARS VS RSQHIN IID, NLS II IEA NY a EEN EAN INANE ERY SMSSCY, EN RIANA AY ONU CSOUISTIS AL FD Ian pu pren a Ben aq Din à 5 nant LE NA TX vane HESSEN DTD EN A Seen banded à Fen RT ESS INANCT AURA Silastraolhamihvyiinaosant mmnainanaoessgs RO A RSI IE faphivismise HA Bim As ÉNSCUOCHENTEUNINEGSCOnt HTIMUNOSSSSY (ELU, ELIA TECHMIQUES, Ks, ELOPOT, AFM, RAS Ar MTS TANT SA with anaivene EMI LE TER DIRE INARI SNA WATT FEIN ONAN IVICA Rn, SN ND Lond 4 À + A 8 Fen a Ta en ey RS à 05 Ÿ ps pe how oy gen Ni ere pue a ee $ Pan SNE § Toni & 21 A mathod for datarmining at At least ong antinen noalvnanticle acearding to any one of claims SES INSISQUI TOV COSTA at (CASE Une SITE PI PONS Ging 10 dy Ong Or Gains PEAU sAaminrieinn Ha faiimainn stanse- 1910 ZU, COMDrISTIQ TE TOHOWINGQ SISDS! Ss dt oo N Ta 3 A + ST ni KUN an Fes À Frs wy Wb eat a. He FAR WEN a a pu a 00e prey em Ny a fo) Natarminins TRS SNR cu camiansaial Team at laset ans viral sansmeae nraforahie (à) Jaiamining ne aiming adi SSOQUENCE(S) rom at 10851 ong Vrai genome, protoraniy ER EMS HAHN LEE KISSINGEN EIN SUN SN PRES CUS SN NAN TN ARE CN a ER a SNS IS NAN a CNE ÉD te SE Che HT ON CU EN ER $ N OFFICE SS EN INN saine € Sir An eat ex aqentes nn the val ciirfanpe £3 HOM VIUS SEQUENCING DICISINS COMamng vital SDRODSES D'ESSMEl On ing LOTS OF SUITAGS, “i an an or ' Rag on ee N ie SEN NN en des À ace etn see Bes da = Hd ens u 3 ant ee dan end pags vad a fen Fan FRY) oarmnaring Tha amimn acid samianecais) nrafarabhy thinge datarmiinas apporte ia fa {0} COMParning ma amine adil SSQUENCEO(S), pratelatly Ios aaudiminad aCtorQing wo {a}, with thoae of at Let another raiated virus and datarmining he sansearvar raie in Win NOSE OF al IGSS ORD OMIS TOISISQ Vitus and GEITSDITHTENG ing Conserved ragions HN tha viral nannimae the viral GSNOMSS, > io) determinino amino acid seayuence( s) corresnondina to MHC class | and/or class Ah SSII DS CHI Qh DOME VOLS? WITT OMI EU INT Dar GDS 8 CHIMIE MER 0 an comnisves and/ar matching to Beoalis, preferably helonaing to consarvad viral anions WS GAMITHIICATS QIU PRIS IS V2 DST UGS PASS allay CSD TAG 10 LUNI VOS Wired CPV ER SUL an pr on ve one dem en Seb 8 en me 23 rene hey an a Cann yen an ad ane ae en Rah MSSNISHÉS\ mars Nraferaihhe hace datarminasd sssmnaiirens fe or PECHOTHES), MOTS Prataranly nose Gauaimingy adCoragmg 10 (DD), PMOR GmbH DARA ONES IDE NUN FIR AN AND HE ver run I have. AN N aa PRIC-GCOS-P-LU(ZI 28.02 2023 Luxembourg Palentanmaldung an A Aavalinniss eunthatie anfisen snd Aa tail ét ; 3 {hh develanına synihetis antinan nolvnantideis) pantaining FR EVIE sein OAM SSS {G) SING SYyMNSUC antigen DOVDODUGE(S) Comammng INS amine SCH SOQUENCES, A Pen an A be 2 HS à 3 à 3 ae ; nrafaraiiks caloeiad nnnneelinn IA (A amet state Lai ; ; eden i orefarably assisted according to ia © and determining the Ai! ans § y (SU OMAN 15 {Gy SNS AEG ne SIV SIGIOMICET ang F3 > in LE Là 4: me sinachantienl nrnnertise DINRICQONSMICal Dronperties Ft S , Mare SPOCHIC at PAST wo, more préterapiy ai $ least thres moat orafarably un tn fwealvs anfinen nod He $ Hi ; 3 feast three, most preferably un to hwelve antigen nolvnentide(s), praferabiy accordine , S SAN UN IL KNWVERTVES SELL NUS DC LMU, PITTS aidly IA Se FAN awalnil bene Li X Coden a fey fel) while ransiderina MA alate Alchrihatean af the thai Yan £ to fd) while considering HLA allele distribution of the worldwide population, ore Bar ah PO, WHE CONSICONNG MLA SHS GISTHIDUTION OF INS WOTIKAWIGS DODUISTION, praferamy case c KAT = = X, a ï sy 2 © = Siena MAT vwaîinhtines ainsi Sa the antin t si Imst using a ML Weichtine aigonthm far the antigen nobrnantide ssisctior USING à ML WEWICHNUNG Sigoninm TOI ine anugen DOIVDEDIQE SSISCHOM. ay Ten ANUS fe Las A : © a 20 Tha Ratios of Slaten DU voharnim Se wired 34 od 3 : $, 22 The Method of claim 21 wherein the viral enitones are determined from a coronavirus IS MENON OF Claim 21, WIISPEIN Ig viral SDRORES arg GETSIITENMSC TOM a foranavirus AN & aa 2 #ë 18% pass Nrafneaishe fran à Matas PR Ven bd T, sarbeun Ps amt i Fay Hom à DEaCOronavirusg, ospadidny Drararany ram 9 SafDECOVHUS, most nrefarahhs from à SARKIS vive NISTOTADIV WOM 8 OAR LV -2 VITUS, AS The Bead bd od ar Le - a 23 The Atathan of amy of the slisime 51 andior 22 iresraier The Trend 4 y. ve À A TP NISTHON OT any OT Ihe Slams ZT andior 22 WTS MENT TS Vira! SDITODES, prataraniy irom VOTING Claims 27 anol Le, Wea Ne viral SPHODSS, prataramy wom CARNES Say fy LA sx UE à A QAR OMAD virus are CNMmnArSN wih ails + 3 i SYALIEY PSN I = : ç a SARS-CoV-9 virus, are compared with wild type. such as the SARS-Col-2 wild tvne Pu ; TS COMPArad WN Wit TYPES, SUCH SSID OARS-LOV-L WEG VDS HU AN 4 AfA een x = Wd x : «à ; ER I oanmalfar mudante nrafarahle anch se the Anka (D 4 4 7A 5 Date / 4 2R4 + |, and/or mutants, preferably such as the Alpha (8.14.7), or Sata (5.1351) or Gamma S, proferabdly SUCH as Ine Aha {5 1.1.50, OF DGA (1,307), OF amma PE PAUL PES 4 RE * cs —~ iT 4 ne NN SEY À RP PM evan ad f EN 5 FoI FOS P 4 or Delta BR 1 847 %andor Omicron variant 1 1 4 SOO UT OT DORA (9.1.00) SNOT UNHOron VENTO). SA "PAL RA Le = Là ARR RUN VA Tha Mathias AT sn of tha sisime 71 ia 99% i ; “1 $i X i X ç SA The Method of any of the claims 21 to 2 wharein tha gunthatio i tied {i 24 The Method of anv of the claims 21 to 73 wherein the synthetic nolvnentides creatad in y NS LIENS 21 10 20, WISSEN ING SYMIMIQUE DOVDODLIGES Of eaisd IN eu SA cu, iy ï “a = - STE AY ATR Aantinan PNA TOUS SN BANN cl don oy AN op ao Feng : : Gi x sian (Ay are antigen nalımnenlides consisting of tandem and/or ovarianning antigen OST £3 dm LG) are antigen DOYPSDIIGES Consisting OT ianasim andor gvenappmg antigen pepiides pe pe = = FEARS ~~ x TI ; ait WY PAPA AN te ARC 1 ancior RAR I same] ; Comin] = \ Si ZU corresnondine to MMO and/or MHC HH comniexes and matching B-cell and T-cell soitonpes "LPS ENS MEL AUTRE ALS MEN NN à GREEN Le ST ILE EE GG TAILAN DO © MIRATONING SCOR SNS 1 NS] LOCK S A i MATE GRA EAEATD QFE THELEN Ltt QE LS CNRS S. ME Phe Redd se eat Le 4 - 35 Tha Mathad af any of tha plaime OÙ 3a DA Aalen ead § CS «, pat ä à 3 st

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RARE. DE EN “a - PNC-0005-P-LUS2) 28 059 2093 would be aA gees iesesben Thess aad en Le) L002 Aad LUXEMOUTEISCHS Faenianimaiqung an VU SOUPE A 8 dared AS ar Das VF Tha Mathad of anv of the cinime DA andor VA } is 4 Ki

27. The Method of any of the claims 25 and/or 95, wherein the subiecis are humsy HOF ING CISIMS £0 andiir JU, WRSTSIN Ing SUDISCIS arg numan, OR The Mot ne eat 28 Thao Mathes af ame af tha ploime POUF 3 toy £48

28. The Method of any of the claims 21-27 wherein the aensrated amir ici EN BERING QT GTV QU DIS EU PTT 2 WNHSTEIT TNO CETSTSISS amiing SKIN SSSTISTNES ars 3 & “fi, WHSTON ING GETTING amma ati SSQUSNCSS are & galantan fram OO NN Aie 72 ze if € 0 seiscteo from SEO ID NOs, 38 — 58 ma SN an SBCA TON DEL 12 RUS. 50 — 50 MATERIAL SU — SAL SN A a N © $ PS A MAN TO Oranannia A nharmsaost ie Ve 343 2: AZ A MANO TO! D'EDAITTO a DHATMATSEUTION COMDOSITON acsoramg ty any ana af ola i i FRITS À ENERGIEN LONGI Ly ina to any one of claims 110 Prey da CSU! COMPOSITION ACCOMIING 10 any ong OT Clams 110 18 comprising the following steps: TD, VASTE NT EON TAG LE TRARY SIND, A LAN a A Le ; iN Foal or ben ben en ond ja $ 3 ta à { ; fa detarmininn at inset ane ta en a iy oad & À = ui § IQ {RY GHISTIMEUNO AT 18880 Ong, orefaraply al 10agt wo, More ore Haran $d $ + 17 ISTTHAMNG 81 ISSS ONE, DISTGTADIY al 10881 Wa, MOIS DrETGTADIY al Gast rae ' : À SON à SOS WH, MOTS DTOIGTODIY av eds tres, nantisetarie nrafarahhe af mast fuss $ i ï > particularly preferably at least five, most preferably at least 7, alternatively bes À } ATUCUIATIV Protaradly at ERST VE, MOST praterainy 81 18a alternatively up to twelve i vi \ Sas VO, MOST DISTSTEDIV EL 188s 7, dnamaiively UD TO waive a nalunantidaie) sorraararcling fn RIND a antigen npolvnentide(s) corresponding to MMO class | cominlesves matehing at gen polypenti sis) corresnonadine 3 HO faa Save AURAS Ar KISS o ONAN HE tae J POIVDE] (8) QSRONGING 10 MHL CIASS | COMQISXES Maloning AT ISAST ane > TARE NEN IE SY TR EN SN eel + +5 i 3 § viral onttinne acearding in the method of ar ; Yoni SO T4 ied Viral enfans gooording to the mathod of any one glam 2534 which ar toh > PTS ALATA IL LAS LEURS TELE ERA AH any VIE DAY See Ré ATOS SPA matomnims PILOT 9 INA OF any ONE CAIN 20-04, WHICH ar6 maining = Hrefarahie of loool OR 84 minra rate ad 2} san 6 ra OURateraDiy al I8aST BD Ya, MOOS Drarsraniy ar sass OR 04 af EINES woot air SE A ef § YORU IDAS VD Yo, NOTE Drafaranty at gas VS © OT ING MOST COMMON MLA algal 18 distributed in the worldhwids nponulation 2 HIS VAR OU LES dvi nae MOLI, HY) synthesizing the antinen oolvnantinad) {3 RA BY svnthesizing the antigen poivnentids(s) corresponding io MMC class | i * > mas Ma YE + > an TRE sir EN SELS + 3; La HH N ESSEN RS NENG {D} 5 q q POYYDEDUGES(S) COTSSDONONS 10 AML CSSS | COMbIEXES Natarminan in sten fat GEASMNTENSC IN SSD (A) SP (ai, FAX ALAN en len Être & ci 3 i fe nrenarma the nharmaneuthissal sony + \i N à ' {oc} preparing the pharmaceutical comnosition according to the inventic ini NFA MSHI NE MIO OO LINLO GOT MO OMIS according to the Invention comprising ai N 3 PHIM SIINAEY fa WTR NE comprise zZ ; © x ; ons antigen DOIVDODHOS(S) corasponding 10 MMO class | complexes matching at GEN DONDSDUGSIS} COITSSDONOMNG 10 MI CESS | COMDIGXSS maening ai ; 3 se A 3 tnt : A ame A en! aaa nrofaratsiks : HY : SU least ong viral anitope. preferably in a suitable pharmaceutical À tai LI si WH SIAN SVEN © Vi € HIDE OHANTTACEUTION OPITILHETION Hall SD, PIOISTANIY in à sia PhATMAaAcEuteai TOrTIHATON, RATS AU FMCR GmbH DAN AE DU PEN PAMO-OG05-P-LÜCZ) 28.02 2023 Luxembourgish P i id L002 EVE LUKSIMDUrgisona Haiagntanmaiquing

Claims

1. A pharmaceutical composition for use as a medicament, in particular for use in the therapeutic or prophylactic treatment of a coronavirus infectious disease, in particular in a subject or group of subjects suffering from or at risk of contracting a coronavirus infectious disease, comprising a pharmacologically effective amount consisting of at least one antigen polypeptide sequence comprising at least one HLA-A and/or HLA-B antigen peptide, wherein the HLA antigen peptide corresponds to at least one amino acid sequence in the coronavirus, such as spike S1 domain, S2 domain, nucleocapsid protein, envelope protein and/or ORF1ab polyprotein, characterized in that the antigen polypeptide sequence comprises the following framework amino acid sequence: (a) a long peptide, i.e. a compound, construct or polypeptide, the amino acid sequence of which comprises an HLA-A antigen peptide or an HLA-B antigen peptide as defined herein, wherein the amino acid sequence comprises up to 1 to 30 amino acids in addition to the HLA-A antigen peptide or HLA-B antigen peptide; and/or (b) a similarity peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined under (a) or (b), wherein the HLA-A antigen peptide or HLA-B antigen peptide defined herein has less than 100% sequence identity or similarity to the native HLA antigen peptide, such as at least 85%, more preferably at least 90% sequence identity; and/or (c) a substitution peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined under (a) or (b), wherein the HLA-A antigen peptide or the HLA-B antigen peptide as defined herein has an amino acid sequence which comprises or consists essentially of only one amino acid substitution PMCR GmbH PMC-0005-P-DE(2) 27.03.2023 German patent application relative to the amino acid sequence of the native HLA antigen peptide; and/or (d) a tandem peptide whose amino acid sequence is as defined in point (a), comprising or consisting of at least 2 identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c); and/or (e) an overlapping tandem peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined in point (a), comprising or consisting of at least 2 identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c), in which the at least two HLA antigen peptides overlap in their amino acid sequence.

2. The pharmaceutical composition according to claim 1, wherein the HLA-A and/or HLA-B antigen peptide corresponding to MHC class I complexes is selected to match a sequence of the viral epitope of the SARS-CoV-2 virus, such as the SARS-CoV-2 wild type Hu-1 and in particular mutants such as the alpha (B.1.1.7), or beta (B.1.351), or gamma (P. 1), or delta (B.1.617.2) and/or omicron variant

(B.1.1.529).

3. The pharmaceutical composition according to claim 1 or 2, wherein the HLA-A and/or HLA-B antigen peptide is an amino acid sequence selected from the group consisting of SEQ ID NO: 1-37, 59-79.

4. The pharmaceutical composition according to any one of claims 1 to 3, wherein the antigen polypeptide is an amino acid sequence selected from the group consisting of SEQ ID NOs 38-58.

5. The pharmaceutical composition according to any one of claims 1 to 4, further comprising at least one amino acid sequence encoding an HLA-A or HLA-B antigen PMCR GmbH PMC-0005-P-DE(2) 27.03.2023 German patent application

Peptide, wherein the HLA peptide corresponds to at least one amino acid sequence in the coronavirus, such as spike S1 and S2 domains, nucleocapsid protein, envelope protein and/or ORF1ab polyprotein.

6. The pharmaceutical composition according to any one of claims 1 to 5, wherein the pharmaceutical composition comprises at least two antigen polypeptides, wherein the HLA-A and/or HLA-B antigen peptides of the at least two antigen polypeptides correspond to a combination of different parts of the coronavirus epitope selected from the spike S1 domain, S2 domain, nucleocapsid protein, envelope protein and/or ORF 1ab polyprotein.

7. The pharmaceutical composition according to any one of claims 1 to 6, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier liquid and a pharmaceutically acceptable adjuvant, carrier, diluent and/or excipient.

8. The pharmaceutical composition according to any one of the preceding claims for the use specified in claim 1, wherein the pharmaceutical composition is administered subcutaneously, intramuscularly or intradermally.

9. The pharmaceutical composition of claim 8, wherein the subject is a human.

10. The pharmaceutical composition according to any one of claims 1 to 9 for the use specified in claim 1, wherein the HLA antigen peptides and/or antigen polypeptides corresponding to MHC class I complexes are immunogenic antigen peptides determined by means of an immunogenicity test, in particular (but not limited to) by means of Western blot, electrochemiluminescence immunoassay (ECL), ELISA techniques, ELISPOT, ICS, AFM, MS or immunodetection with microscopic analysis. PMCR GmbH PMC-0005-P-DE(2) 03/27/2023 German patent application

11. The pharmaceutical composition according to any one of claims 1 to 10 for the use specified in claim 1, further comprising at least one HLA-A antigen peptide and/or HLA-B antigen peptide corresponding to MHC class I complexes.

12. The pharmaceutical composition according to any one of claims 1 to 11 for use according to claim 1, wherein the antigen polypeptide corresponding to the respective subtype of the MHC class I complexes is selected from the group consisting of the amino acid sequences shown in SEQ ID Nos. 1-58 or having at least one amino acid substitution with respect to these amino acid sequences.

13. The pharmaceutical composition according to any one of the preceding claims for use according to claim 1, wherein the pharmacologically effective amount of each antigen polypeptide in the composition is in an absolute concentration

(i.e. administration dose) is in the range of at least 10 to 1000 ug.

14. The pharmaceutical composition according to any one of the preceding claims for the use specified in the claim, wherein the pharmaceutical composition is administered as prophylaxis or as first-line therapy to the subjects or group of subjects having at least one identical HLA allele.

15. An antigen polypeptide, preferably for use as a medicament, in particular for use in the therapeutic or prophylactic treatment of a coronavirus infectious disease or for a pharmaceutical composition according to one of claims 1 to 14, comprising at least one HLA-A and/or HLA-B antigen peptide, wherein the HLA antigen peptide preferably corresponds to, is identical to, at least one amino acid sequence in the coronavirus, such as spike S1 and S2 domain, nucleocapsid protein, envelope protein and/or ORF1ab polyprotein, wherein the antigen polypeptide sequence comprises the following framework amino acid sequence: PMCR GmbH PMC-0005-P-DE(2) 27.03.2023 German patent application

(a) a long peptide, i.e. a compound, construct or polypeptide, the amino acid sequence of which comprises an HLA-A antigen peptide or an HLA-B antigen peptide as defined herein; the amino acid sequence further comprises up to 1 to 30 amino acids; and/or (b) a lookalike peptide, i.e. a compound, construct or polypeptide, the amino acid sequence of which is as defined under (a) or (b), wherein the HLA-A antigen peptide or HLA-B antigen peptide as defined herein has less than 100% sequence identity or similarity to the native HLA antigen peptide, such as at least 85%, more preferably at least 90% sequence identity; and/or (c) a substitution peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined under (a) or (b), wherein the HLA-A antigen peptide or the HLA-B antigen peptide as defined herein has an amino acid sequence which comprises or consists of essentially only one amino acid substitution relative to the amino acid sequence of the native HLA antigen peptide; and/or (d) a tandem peptide whose amino acid sequence is as defined in point (a), comprising or consisting of at least 2 identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c); and/or (e) an overlapping tandem peptide, i.e. a compound, construct or polypeptide whose amino acid sequence is as defined in point (a), comprising or consisting of at least 2 identical or different HLA-A and/or HLA-B antigen peptide sequences, both as defined in points (a) to (c), in which the at least two HLA antigen peptides overlap in their amino acid sequence.

16. The antigen polypeptide of claim 15, wherein the antigen polypeptide sequence comprises the following framework amino acid sequence: PMCR GmbH PMC-0005-P-DE(2) 27.03.2023 German patent application

(a) an amino acid sequence comprising or consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 38-58 and/or (b) an amino acid sequence having less than 100% sequence identity or similarity to the amino acid sequence of item (a), such as at least 85%, more preferably at least 90%, sequence identity (as defined herein) with an amino acid sequence of SEQ ID NOs: 38-58; and/or (c) an amino acid sequence whose amino acid sequence is as defined in item (a) and which comprises or consists of essentially only one amino acid substitution with respect to the amino acid sequence(s) selected from the group consisting of SEQ ID NOs: 38 - 90; and/or (d) a tandem peptide, i.e. a compound, a construct or a polypeptide which comprises or consists of at least two identical or different peptide sequences of at least one of the sequences defined under (a) to (c), wherein the amino acid sequences are optionally linked to one another by suitable linkers (so-called oligopeptides); and/or (e) an overlapping tandem peptide which comprises or consists of at least 2, preferably 3, such as at least 4 identical or different HLA-A and/or HLA-B antigen peptide sequences (as defined herein) which encode at least two different HLA-A and/or HLA-B antigen peptides (as defined herein), wherein the at least two HLA antigen peptides overlap in their amino acid sequence

17. The antigen polypeptide according to any one of claims 15 and 16, wherein the antigen polypeptide according to the present invention is an overlapping polypeptide which preferably contains between 2 and 10, more preferably between 2 and 8, most preferably between 2 and 6 different amino acid sequences (HLA antigen peptides) which match a viral epitope corresponding to MHC class I and/or MHC class II complexes. PMCR GmbH PMC-0005-P-DE(2) 27.03.2023 German patent application

18. The antigen polypeptide of any one of claims 15-17, wherein the antigen polypeptide is selected from the group consisting of the amino acid sequences shown in SEQ ID

Nos. 38-58 are listed.

19. The antigen polypeptide of any one of claims 15 to 18 for use as a medicament, in particular for use in the therapeutic or prophylactic treatment of a coronavirus infectious disease, the method comprising administering to the subject a treatment regimen containing a pharmacologically effective amount of the antigen polypeptide.

20. The antigen polypeptide according to any one of claims 15 to 19 which is immunogenic in the patient or group of patients, determined by an immunogenicity test, in particular by Western blot, electrochemiluminescence immunoassay (ECL), ELISA techniques, ICS, ELISPOT, AFM, MS or immunodetection with microscopic analysis.

21. A method for determining at least one antigen polypeptide according to one of claims 15 to 20, comprising the following steps: (a) determining the amino acid sequence(s) from at least one viral genome, preferably from virus sequencing proteins, which contain viral epitopes presented on the viral surface, (b) comparing the amino acid sequence(s), preferably those determined according to (a), with those of at least one other related virus and determining the conserved regions in the viral genomes, (c) determining amino acid sequences that correspond to MHC class I and/or class II complexes and/or match B cells that preferably belong to conserved viral epitope regions, preferably those determined according to (b), PMCR GmbH PMC-0005-P-DE(2) March 27, 2023 German patent application

(d) developing synthetic antigen polypeptides containing the amino acid sequences preferably selected according to (c) and determining the physiological and physicochemical properties, (e) creating a composition of at least one, more specifically at least two, more preferably at least three, most preferably up to twelve antigen polypeptide(s), preferably according to (d), taking into account the HLA allele distribution of the worldwide population, preferably using an ML weighting algorithm for the antigen polypeptide selection.

22. The method of claim 21, wherein the viral epitopes are determined from a coronavirus, preferably from a betacoronavirus, more preferably from a sarbecovirus, most preferably from a SARS-CoV-2 virus.

23. The method according to any one of claims 21 and/or 22, wherein the viral epitopes, preferably from a SARS-CoV-2 virus, are compared with the wild type, such as the SARS-CoV-2 wild type Hu-1, and/or mutants, preferably such as the alpha (B.1.1.7) or beta (B.1.351) or gamma (P. 1) or delta (B.1.617.2) and/or omicron variant (B.1.1.529).

24.The method of any one of claims 21 to 23, wherein the synthetic polypeptides generated in step (d) are antigen polypeptides consisting of tandem and/or overlapping antigen peptides corresponding to MHC I and/or MHC II complexes and appropriate B cell and T cell epitopes.

26. The method according to any one of claims 21 to 24, wherein at least two, preferably at least three, even more preferably at least four, particularly preferably at least six, most preferably up to twelve antigen polypeptides are intended for use in a combination preparation for the prophylaxis and/or treatment of a group of subjects at risk of contracting a coronavirus infectious disease. PMCR GmbH PMC-0005-P-DE(2) 27.03.2023 German patent application

26. The method according to any one of claims 25, wherein the antigen polypeptides of the combination preparation preferably cover more than 95% of the HLA alleles of the worldwide human population.

27. The method of any of claims 25 and/or 26, wherein the subjects are humans.

28.The method according to any one of claims 21 to 27, wherein the generated amino acid sequences are selected from SEQ ID Nos. 38-58 and/or 80-90.

29. A method for preparing a pharmaceutical composition according to any one of claims 1 to 18, comprising the following steps: (a) determining at least one, preferably at least two, more preferably at least three, particularly preferably at least five, most preferably at least 7, alternatively up to twelve antigen polypeptide(s) corresponding to MHC class I complexes which match at least one viral epitope according to the method of any one of claims 26-34, which preferably match at least 95%, more preferably at least 98% of the most common HLA alleles distributed in the world population; (b) synthesizing the antigen polypeptide(s) corresponding to the MHC class I complexes determined in step (a); (c) producing the pharmaceutical composition according to the invention, which contains at least one antigen polypeptide or antigen polypeptides which correspond to MHC class I complexes which match at least one viral epitope, preferably in a suitable pharmaceutical formulation. PMCR GmbH PMC-0005-P-DE(2) 27.03.2023 German patent application