LT3164B - New selective aromatase inhibiting 4(5)-imidazoles - Google Patents

New selective aromatase inhibiting 4(5)-imidazoles Download PDF

Info

Publication number: LT3164B
Authority: LT; Lithuania
Prior art keywords: imidazole; cyanophenyl; fluorophenyl; pharmaceutically acceptable; compounds
Prior art date: 1991-06-18

Application number

LTIP175A

Other languages

English (en)

Lithuanian (lt)

Inventor

Arto Johannes Karjalainen

Marja-Liisa Soedervall

Arja Marketta Kalapudas

Reino Olavi Pelkonen

Aire Marja Laine

Risto Arvo Sakari Lammintausta

Jarmo Sakari Salonen

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-18

Filing date

1992-08-28

Publication date

1995-02-27

1991-06-18 Priority claimed from GB919113142A external-priority patent/GB9113142D0/en

1992-08-28 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1994-08-25 Publication of LTIP175A publication Critical patent/LTIP175A/lt

1995-02-27 Publication of LT3164B publication Critical patent/LT3164B/lt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

LTIP175A 1991-06-18 1992-08-28 New selective aromatase inhibiting 4(5)-imidazoles LT3164B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919113142A GB9113142D0 (en)	1991-06-18	1991-06-18	New selective aromatase inhibiting 4(5)-imidazoles
GB919125924A GB9125924D0 (en)	1991-06-18	1991-12-05	Stereoisomers of an imidazole derivative

Publications (2)

Publication Number	Publication Date
LTIP175A LTIP175A (lt)	1994-08-25
LT3164B true LT3164B (en)	1995-02-27

Family

ID=26299089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTIP175A LT3164B (en)	1991-06-18	1992-08-28	New selective aromatase inhibiting 4(5)-imidazoles

Country Status (25)

Country	Link
US (1)	US5559141A (fi)
EP (1)	EP0589975A1 (fi)
JP (1)	JPH06508119A (fi)
KR (1)	KR940701386A (fi)
CN (1)	CN1068819A (fi)
AU (1)	AU665002B2 (fi)
BG (1)	BG98306A (fi)
CA (1)	CA2111469A1 (fi)
CZ (1)	CZ280293A3 (fi)
FI (1)	FI935658A (fi)
GB (1)	GB9125924D0 (fi)
HR (1)	HRP920170A2 (fi)
HU (1)	HUT67325A (fi)
IE (1)	IE921963A1 (fi)
IL (2)	IL102216A (fi)
LT (1)	LT3164B (fi)
LV (1)	LV10093B (fi)
MX (1)	MX9203000A (fi)
NO (1)	NO934688D0 (fi)
NZ (1)	NZ243139A (fi)
PT (1)	PT100604A (fi)
SI (1)	SI9200113A (fi)
SK (1)	SK144393A3 (fi)
TW (1)	TW206217B (fi)
WO (1)	WO1992022537A1 (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2273704B (en) *	1992-12-16	1997-01-22	Orion Yhtymae Oy	Triazolyl diaryl selective aromatase inhibiting compounds
SE9302333D0 (sv) *	1993-07-06	1993-07-06	Ab Astra	New compounds
US6063930A (en) *	1996-04-03	2000-05-16	Merck & Co., Inc.	Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6080870A (en) *	1996-04-03	2000-06-27	Merck & Co., Inc.	Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
CA2250231A1 (en) *	1996-04-03	1997-10-09	Robert P. Gomez	Inhibitors of farnesyl-protein transferase
US6297239B1 (en) *	1997-10-08	2001-10-02	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
AU2001275794A1 (en)	2000-07-28	2002-02-13	Sumitomo Pharmaceuticals Co. Ltd.	Pyrrole derivatives
MXPA06003951A (es) *	2003-10-07	2006-06-27	Renovis Inc	Derivados de amida como ligandos del canal de ion y composiciones farmaceuticas y sus metodos de uso.
US7576099B2 (en)	2005-02-28	2009-08-18	Renovis, Inc.	Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
BRPI0606365A2 (pt) *	2005-02-28	2017-06-27	Renovis Inc	composto ou um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo e estereoisômeros e tautômeros do mesmo, composição farmacêutica, métodos para prevenir, tratar, melhorar ou controlar uma doença ou condição e para preparar um composto, uso de um composto ou um sal, solvato ou composição farmaceuticamente aceitável do mesmo, método de tratamento de um mamífero, e, combinação
US7902247B2 (en) *	2008-01-09	2011-03-08	Allergan, Inc.	Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0311447A1 (en)	1987-10-09	1989-04-12	Orion-Yhtymà Oy	Aromatase inhibiting 4(5)-imidazoles
EP0390558A1 (en)	1989-03-30	1990-10-03	Orion-Yhtymà Oy	Aromatase inhibiting 4(5)-imidazoles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4605661A (en) *	1984-06-18	1986-08-12	Eli Lilly And Company	Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
GB2248058B (en) *	1990-09-21	1994-09-14	Orion Yhtymae Oy	Aromatase inhibiting 4(5)-imidazoles
US5439928A (en) *	1989-03-30	1995-08-08	Orion-Yhtyma Oy	Aromatase inhibiting 4(5)-imidazoles

1991
- 1991-12-05 GB GB919125924A patent/GB9125924D0/en active Pending
1992
- 1992-06-12 SK SK1443-93A patent/SK144393A3/sk unknown
- 1992-06-12 US US08/167,873 patent/US5559141A/en not_active Expired - Fee Related
- 1992-06-12 KR KR1019930703934A patent/KR940701386A/ko not_active Application Discontinuation
- 1992-06-12 CZ CS932802A patent/CZ280293A3/cs unknown
- 1992-06-12 WO PCT/FI1992/000184 patent/WO1992022537A1/en not_active Application Discontinuation
- 1992-06-12 EP EP92912309A patent/EP0589975A1/en not_active Withdrawn
- 1992-06-12 CA CA002111469A patent/CA2111469A1/en not_active Abandoned
- 1992-06-12 AU AU19783/92A patent/AU665002B2/en not_active Ceased
- 1992-06-12 JP JP4511061A patent/JPH06508119A/ja active Pending
- 1992-06-15 NZ NZ243139A patent/NZ243139A/en unknown
- 1992-06-15 LV LVP-92-29A patent/LV10093B/en unknown
- 1992-06-16 IL IL10221692A patent/IL102216A/en not_active IP Right Cessation
- 1992-06-17 PT PT100604A patent/PT100604A/pt not_active Application Discontinuation
- 1992-06-17 HR HR920170A patent/HRP920170A2/hr not_active Application Discontinuation
- 1992-06-17 TW TW081104752A patent/TW206217B/zh active
- 1992-06-18 SI SI19929200113A patent/SI9200113A/sl unknown
- 1992-06-18 MX MX9203000A patent/MX9203000A/es unknown
- 1992-06-18 CN CN92105664A patent/CN1068819A/zh active Pending
- 1992-07-01 IE IE196392A patent/IE921963A1/en not_active Application Discontinuation
- 1992-08-28 LT LTIP175A patent/LT3164B/lt not_active IP Right Cessation
1993
- 1993-12-16 FI FI935658A patent/FI935658A/fi not_active Application Discontinuation
- 1993-12-17 HU HU9303653A patent/HUT67325A/hu active IP Right Revival
- 1993-12-17 BG BG98306A patent/BG98306A/bg unknown
- 1993-12-17 NO NO934688A patent/NO934688D0/no unknown
1995
- 1995-09-27 IL IL11543995A patent/IL115439A0/xx unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0311447A1 (en)	1987-10-09	1989-04-12	Orion-Yhtymà Oy	Aromatase inhibiting 4(5)-imidazoles
EP0390558A1 (en)	1989-03-30	1990-10-03	Orion-Yhtymà Oy	Aromatase inhibiting 4(5)-imidazoles

Also Published As

Publication number	Publication date
FI935658A0 (fi)	1993-12-16
LV10093A (lv)	1994-05-10
JPH06508119A (ja)	1994-09-14
CA2111469A1 (en)	1992-12-23
AU665002B2 (en)	1995-12-14
LV10093B (en)	1995-02-20
FI935658A (fi)	1993-12-16
PT100604A (pt)	1993-10-29
LTIP175A (lt)	1994-08-25
HUT67325A (en)	1995-03-28
IL115439A0 (en)	1995-12-31
NO934688L (no)	1993-12-17
HRP920170A2 (en)	1994-08-31
US5559141A (en)	1996-09-24
IL102216A (en)	1996-06-18
KR940701386A (ko)	1994-05-28
BG98306A (bg)	1994-08-30
MX9203000A (es)	1993-02-01
CN1068819A (zh)	1993-02-10
IE921963A1 (en)	1992-12-30
NO934688D0 (no)	1993-12-17
IL102216A0 (en)	1993-01-14
HU9303653D0 (en)	1994-04-28
GB9125924D0 (en)	1992-02-05
SI9200113A (en)	1992-12-31
TW206217B (fi)	1993-05-21
WO1992022537A1 (en)	1992-12-23
SK144393A3 (en)	1994-11-09
CZ280293A3 (en)	1994-05-18
EP0589975A1 (en)	1994-04-06
AU1978392A (en)	1993-01-12
NZ243139A (en)	1994-08-26

Publication	Publication Date	Title
US5098923A (en)	1992-03-24	Aromatase inhibiting 4(5)-imidazoles
LT3164B (en)	1995-02-27	New selective aromatase inhibiting 4(5)-imidazoles
EP0674626B1 (en)	2000-07-19	Selective aromatase inhibiting compounds
EP0390558B1 (en)	1994-09-07	Aromatase inhibiting 4(5)-imidazoles
US5439928A (en)	1995-08-08	Aromatase inhibiting 4(5)-imidazoles
EP0476944B1 (en)	1995-11-15	Aromatase inhibiting 4(5)-imidazoles
PL162554B1 (pl)	1993-12-31	S posób wytwarzania nowych pochodnych imidazolu PL PL PL PL PL
FI63016C (fi)	1983-04-11	Foerfarande foer framstaellning av en terapeutiskt aktiv propanolamin
FR2548183A1 (fr)	1985-01-04	Diphenylazomethines portant un radical imidazolyle, leur preparation et leur application en therapeutique
PL162555B1 (pl)	1993-12-31	Sposób wytwarzania nowych pochodnych imidazolu PL

Legal Events

Date	Code	Title	Description
1998-04-27	MM9A	Lapsed patents	Effective date: 19970828