LT2838883T - Nauji feniltetrahidroizochinolino dariniai - Google Patents
Nauji feniltetrahidroizochinolino dariniaiInfo
- Publication number
- LT2838883T LT2838883T LTEP13716291.3T LT13716291T LT2838883T LT 2838883 T LT2838883 T LT 2838883T LT 13716291 T LT13716291 T LT 13716291T LT 2838883 T LT2838883 T LT 2838883T
- Authority
- LT
- Lithuania
- Prior art keywords
- tetrahydroisoquinoline derivatives
- new phenyl
- phenyl
- new
- tetrahydroisoquinoline
- Prior art date
Links
- PRTRSEDVLBBFJZ-UHFFFAOYSA-N 1-phenyl-1,2,3,4-tetrahydroisoquinoline Chemical class N1CCC2=CC=CC=C2C1C1=CC=CC=C1 PRTRSEDVLBBFJZ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/074170 | 2012-04-17 | ||
| PCT/EP2013/057761 WO2013156423A1 (en) | 2012-04-17 | 2013-04-15 | New phenyl-tetrahydroisoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2838883T true LT2838883T (lt) | 2018-01-25 |
Family
ID=48095859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13716291.3T LT2838883T (lt) | 2012-04-17 | 2013-04-15 | Nauji feniltetrahidroizochinolino dariniai |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9187429B2 (lt) |
| EP (1) | EP2838883B1 (lt) |
| JP (1) | JP6144755B2 (lt) |
| KR (1) | KR20150001828A (lt) |
| CN (1) | CN104245674B (lt) |
| AR (1) | AR090678A1 (lt) |
| CA (1) | CA2861060A1 (lt) |
| DK (1) | DK2838883T3 (lt) |
| ES (1) | ES2655066T3 (lt) |
| HR (1) | HRP20171996T1 (lt) |
| HU (1) | HUE035274T2 (lt) |
| LT (1) | LT2838883T (lt) |
| MX (1) | MX2014009712A (lt) |
| NO (1) | NO2838883T3 (lt) |
| PL (1) | PL2838883T3 (lt) |
| PT (1) | PT2838883T (lt) |
| RS (1) | RS56703B1 (lt) |
| RU (1) | RU2014144883A (lt) |
| SI (1) | SI2838883T1 (lt) |
| TW (1) | TW201345895A (lt) |
| WO (1) | WO2013156423A1 (lt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3057940A1 (en) * | 2013-10-17 | 2016-08-24 | F.Hoffmann-La Roche Ag | Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthase |
| RU2016116433A (ru) * | 2013-10-17 | 2017-11-22 | Ф. Хоффманн-Ля Рош Аг | Новые производные фенил-дигидропиридина в качестве ингибиторов альдостерон синтазы |
| EP3227300B1 (en) | 2014-12-02 | 2019-06-19 | Boehringer Ingelheim International GmbH | Aldosterone synthase inhibitors |
| MY196809A (en) | 2015-12-24 | 2023-05-03 | Kyowa Kirin Co Ltd | (),()-unsaturated amide compound |
| US11447471B2 (en) | 2017-06-23 | 2022-09-20 | Kyowa Kirin Co., Ltd. | α,β-unsaturated amide compound |
| US11958818B2 (en) | 2019-05-01 | 2024-04-16 | Boehringer Ingelheim International Gmbh | (R)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate |
| CN113325096B (zh) * | 2021-05-08 | 2022-12-13 | 石家庄四药有限公司 | 一种1-(2,3-二甲基苯基)乙醇有关物质的检测方法 |
| WO2023114170A1 (en) | 2021-12-14 | 2023-06-22 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors for treating chronic kidney disease |
| WO2024061371A1 (zh) * | 2022-09-23 | 2024-03-28 | 广州威诺森医药科技有限公司 | 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用 |
| TW202444716A (zh) * | 2023-04-11 | 2024-11-16 | 大陸商上海翰森生物醫藥科技有限公司 | 苯並稠環類化合物抑制劑、及其製備方法和應用 |
| CN117247371A (zh) * | 2023-09-18 | 2023-12-19 | 上海相辉医药科技有限公司 | 一种cyp11b2抑制剂baxdrostat的制备方法 |
| WO2025098465A1 (zh) * | 2023-11-10 | 2025-05-15 | 上海齐鲁制药研究中心有限公司 | 稠环衍生物、其制备方法及其在医药上的应用 |
| CN121135736A (zh) * | 2024-03-01 | 2025-12-16 | 浙江扬厉医药技术有限公司 | 吡喃并吡啶类化合物、其制备方法、药物组合物及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US20060111394A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| US9271963B2 (en) * | 2005-03-03 | 2016-03-01 | Universitat Des Saarlandes | Selective inhibitors of human corticosteroid synthases |
| CN101440096A (zh) * | 2005-07-11 | 2009-05-27 | 浙江大学 | 1-(3＇,4＇,5＇-三取代苯基)-四氢异喹啉类化合物及其用途 |
| AU2007267793A1 (en) * | 2006-05-26 | 2007-12-06 | Novartis Ag | Aldosterone synthase and/or 11beta-hydroxylase inhibitors |
| BRPI0721284A2 (pt) * | 2006-12-18 | 2014-04-08 | Novartis Ag | Compostos orgânicos |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| WO2010112799A1 (en) * | 2009-02-26 | 2010-10-07 | University Of York | Luminophores comprising platinum-ligand complexes |
| CA2761858A1 (en) * | 2009-05-15 | 2010-11-18 | Novartis Ag | 5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or cyp11b1 |
| US9353081B2 (en) * | 2011-09-23 | 2016-05-31 | Hoffmann-La Roche Inc. | Bicyclic dihydroquinoline-2-one derivatives |
-
2013
- 2013-04-15 JP JP2015506196A patent/JP6144755B2/ja active Active
- 2013-04-15 ES ES13716291.3T patent/ES2655066T3/es active Active
- 2013-04-15 PL PL13716291T patent/PL2838883T3/pl unknown
- 2013-04-15 DK DK13716291.3T patent/DK2838883T3/en active
- 2013-04-15 HR HRP20171996TT patent/HRP20171996T1/hr unknown
- 2013-04-15 RU RU2014144883A patent/RU2014144883A/ru not_active Application Discontinuation
- 2013-04-15 LT LTEP13716291.3T patent/LT2838883T/lt unknown
- 2013-04-15 HU HUE13716291A patent/HUE035274T2/en unknown
- 2013-04-15 KR KR20147032004A patent/KR20150001828A/ko not_active Withdrawn
- 2013-04-15 WO PCT/EP2013/057761 patent/WO2013156423A1/en not_active Ceased
- 2013-04-15 RS RS20180014A patent/RS56703B1/sr unknown
- 2013-04-15 AR ARP130101202A patent/AR090678A1/es unknown
- 2013-04-15 CA CA2861060A patent/CA2861060A1/en not_active Abandoned
- 2013-04-15 NO NO13716291A patent/NO2838883T3/no unknown
- 2013-04-15 SI SI201330910T patent/SI2838883T1/en unknown
- 2013-04-15 PT PT137162913T patent/PT2838883T/pt unknown
- 2013-04-15 EP EP13716291.3A patent/EP2838883B1/en active Active
- 2013-04-15 MX MX2014009712A patent/MX2014009712A/es unknown
- 2013-04-15 CN CN201380020331.5A patent/CN104245674B/zh active Active
- 2013-04-15 TW TW102113353A patent/TW201345895A/zh unknown
- 2013-04-17 US US13/864,889 patent/US9187429B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104245674B (zh) | 2017-07-11 |
| WO2013156423A1 (en) | 2013-10-24 |
| SI2838883T1 (en) | 2018-02-28 |
| RU2014144883A (ru) | 2016-06-10 |
| CA2861060A1 (en) | 2013-10-24 |
| PT2838883T (pt) | 2018-01-04 |
| JP6144755B2 (ja) | 2017-06-07 |
| PL2838883T3 (pl) | 2018-05-30 |
| DK2838883T3 (en) | 2018-01-15 |
| EP2838883B1 (en) | 2017-11-08 |
| HK1200817A1 (en) | 2015-08-14 |
| AR090678A1 (es) | 2014-11-26 |
| US9187429B2 (en) | 2015-11-17 |
| RS56703B1 (sr) | 2018-03-30 |
| NO2838883T3 (lt) | 2018-04-07 |
| TW201345895A (zh) | 2013-11-16 |
| US20130274287A1 (en) | 2013-10-17 |
| CN104245674A (zh) | 2014-12-24 |
| HRP20171996T1 (hr) | 2018-02-09 |
| ES2655066T3 (es) | 2018-02-16 |
| JP2015514732A (ja) | 2015-05-21 |
| KR20150001828A (ko) | 2015-01-06 |
| MX2014009712A (es) | 2014-09-12 |
| EP2838883A1 (en) | 2015-02-25 |
| HUE035274T2 (en) | 2018-05-02 |
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