[go: up one dir, main page]

LT2767292T - Palaikomosios vietinės anestezijos mišinys su saib - Google Patents

Palaikomosios vietinės anestezijos mišinys su saib

Info

Publication number
LT2767292T
LT2767292T LTEP14167954.8T LT14167954T LT2767292T LT 2767292 T LT2767292 T LT 2767292T LT 14167954 T LT14167954 T LT 14167954T LT 2767292 T LT2767292 T LT 2767292T
Authority
LT
Lithuania
Prior art keywords
composition containing
local anesthetic
sustained local
anesthetic composition
containing saib
Prior art date
Application number
LTEP14167954.8T
Other languages
English (en)
Inventor
Neil A Verity
Original Assignee
Durect Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corporation filed Critical Durect Corporation
Publication of LT2767292T publication Critical patent/LT2767292T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015Drug-containing film-forming compositions, e.g. spray-on
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Anesthesiology (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Detergent Compositions (AREA)
  • Amplifiers (AREA)
  • Optical Communication System (AREA)
  • Selective Calling Equipment (AREA)
LTEP14167954.8T 2004-09-17 2005-09-15 Palaikomosios vietinės anestezijos mišinys su saib LT2767292T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61079704P 2004-09-17 2004-09-17
US69139505P 2005-06-17 2005-06-17

Publications (1)

Publication Number Publication Date
LT2767292T true LT2767292T (lt) 2016-12-12

Family

ID=35949130

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14167954.8T LT2767292T (lt) 2004-09-17 2005-09-15 Palaikomosios vietinės anestezijos mišinys su saib

Country Status (26)

Country Link
US (9) US8753665B2 (lt)
EP (4) EP2767292B1 (lt)
JP (2) JP5285275B2 (lt)
KR (2) KR101492361B1 (lt)
AT (1) ATE537844T1 (lt)
AU (1) AU2005287175B2 (lt)
BR (1) BRPI0515372B8 (lt)
CA (1) CA2581287C (lt)
CY (2) CY1112625T1 (lt)
DK (3) DK2415484T3 (lt)
EA (2) EA201001885A1 (lt)
ES (3) ES2602273T3 (lt)
GE (1) GEP20094831B (lt)
HK (1) HK1201437A1 (lt)
HR (1) HRP20120254T1 (lt)
HU (1) HUE032040T2 (lt)
IL (1) IL181474A (lt)
LT (1) LT2767292T (lt)
MX (1) MX2007002962A (lt)
NO (1) NO342596B1 (lt)
NZ (1) NZ553369A (lt)
PL (2) PL2415484T3 (lt)
PT (3) PT2415484E (lt)
RS (1) RS52198B (lt)
SI (2) SI2767292T1 (lt)
WO (1) WO2006033948A2 (lt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
PL2415484T3 (pl) 2004-09-17 2014-11-28 Durect Corp Kompozycja znieczulająca miejscowo o przedłużonym uwalnianiu zawierająca SAIB
CA2582096C (en) * 2004-10-01 2014-01-07 Ramscor, Inc. Conveniently implantable sustained release drug compositions
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
DK2117521T3 (da) 2006-11-03 2012-09-03 Durect Corp Transdermale indgivelsessystemer omfattende bupivacain
EP3085363B1 (en) * 2007-03-28 2019-03-20 Innocoll Pharmaceuticals Limited A drug delivery device for providing local analgesia, local anesthesia or nerve blockade
CA2714514C (en) * 2008-02-08 2016-08-16 Qps Llc Non-polymeric compositions for controlled drug delivery
US20100143437A1 (en) * 2008-12-09 2010-06-10 Morris Edward J Implantable analgesic
EP2430037A4 (en) 2009-05-13 2013-07-17 Keraplast Tech Ltd BIOPOLYMER MATERIALS
CN105748402B (zh) * 2010-11-24 2022-06-03 杜雷科特公司 生物可降解的药物递送组合物
ES2985957T3 (es) * 2012-05-16 2024-11-07 Orexa B V Anestésicos locales para facilitar la ingesta de alimentos y retención de alimentos
US9592227B2 (en) 2013-03-15 2017-03-14 Heron Therapeutics, Inc. Compositions of a polyorthoester and an aprotic solvent
JP6537498B2 (ja) * 2013-05-24 2019-07-03 ダンマークス テクニスケ ウニバーシテート 撮像造影用組成物及びキット
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
WO2015123734A1 (en) * 2014-02-21 2015-08-27 The University Of Sydney Liquid carrier materials
WO2018048460A1 (en) 2014-04-21 2018-03-15 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
CN114886899B (zh) 2014-04-21 2024-02-13 赫伦治疗有限公司 长效聚合物输送系统
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
KR20170025011A (ko) 2015-08-27 2017-03-08 고려대학교 산학협력단 통증완화약물의 지속성 방출을 위한 약학적 조성물 및 그 투여를 위한 투여 장치
EP3452031A4 (en) * 2016-05-05 2019-12-11 Liquidia Technologies, Inc. PRECISION-CONTROLLED LOADING AND RELEASE PARTICLES FOR POST-OPERATIONAL PAIN
CA2972296A1 (en) * 2016-06-30 2017-12-30 Durect Corporation Depot formulations
US10682340B2 (en) 2016-06-30 2020-06-16 Durect Corporation Depot formulations
RU2749398C2 (ru) * 2016-12-26 2021-06-09 Целликс Био Прайвет Лимитед Композиции и способы лечения хронической боли
HUE053472T2 (hu) * 2017-03-27 2021-06-28 Fruithy Holdings Ltd Gyengén oldódó komplex vagy szolvátja, gyógyászati készítmény és alkalmazása
CN111432807A (zh) 2017-10-06 2020-07-17 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
RU2674025C1 (ru) * 2017-10-25 2018-12-04 Общество с ограниченной ответственностью "Научно-производственная фирма "ЭЛЕСТ" (ООО "НПФ "ЭЛЕСТ") Лекарственное средство на основе порфиринового фотосенсибилизатора копропорфирина для лечения рака кожи методом фотодинамической терапии
EP4087540A4 (en) * 2020-01-06 2024-01-10 Pacira Pharmaceuticals, Inc. TREATMENT OF PAIN ASSOCIATED WITH CAESAREAN SECTION SURGERY WITH SUSTAINED-RELEASE LIPOSOMAL ANESTHESIC COMPOSITIONS
WO2021141963A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions
US20230130180A1 (en) 2020-01-10 2023-04-27 Pacira Pharmaceuticals, Inc. Treatment of pain by administration of sustained-release liposomal anesthetic compositions
CN115666621A (zh) * 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
CA3168712A1 (en) * 2020-02-25 2021-09-02 The University Of North Carolina At Chapel Hill Eutectic based anesthetic compositions and applications thereof
US11918688B2 (en) 2021-01-11 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of hip pain with sustained-release liposomal anesthetic compositions
CN115068414B (zh) * 2021-03-16 2023-07-21 湖南慧泽生物医药科技有限公司 供注射用罗哌卡因长效溶液制剂及其制备方法
CN117320696A (zh) 2021-03-19 2023-12-29 帕西拉制药股份有限公司 通过给予缓释脂质体麻醉组合物治疗儿科患者的疼痛
CN115414324A (zh) * 2021-05-31 2022-12-02 中国科学院过程工程研究所 一种载局部麻醉药的乳剂及其制备方法
EP4469033A1 (en) 2022-01-28 2024-12-04 Rebel Medicine Inc Pharmaceutical compositions for treating pain
US11918565B1 (en) 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions
US12226610B2 (en) 2022-11-03 2025-02-18 Pacira Pharmaceuticals, Inc. Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions

Family Cites Families (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US556450A (en) * 1896-03-17 Antifriction-bearing
US2931802A (en) 1958-04-30 1960-04-05 Eastman Kodak Co Mixed esters of glucose and sucrose
GB1088992A (en) 1963-09-19 1967-10-25 Squibb & Sons Inc Protective dressings
US4411890A (en) 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US3743398A (en) 1971-03-22 1973-07-03 Eastman Kodak Co Motion picture projector
NO139560C (no) 1972-04-29 1979-04-04 Takeda Chemical Industries Ltd Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater
CA1030526A (en) 1973-11-01 1978-05-02 Samuel Wilkinson Biologically active amides
DE2438350C3 (de) 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2438352A1 (de) 1974-08-09 1976-02-26 Hoechst Ag Peptidcyclopropylamide mit lh-rh/fshrh-wirkung
GB1524747A (en) 1976-05-11 1978-09-13 Ici Ltd Polypeptide
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
JPS55154991A (en) 1979-05-23 1980-12-02 Hisamitsu Pharmaceut Co Inc Beta-d-fructopyranoside derivative
NZ194405A (en) 1979-08-02 1982-05-25 Dut Pty Ltd Producing liquid hydrocarbon streams by hydrogenation of fossil-based feedstock
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
DE3716302C2 (de) 1987-05-15 1996-02-01 Henkel Kgaa Verbesserte resorbierbare Knochenwachse und ihre Verwendung
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
JPS59210024A (ja) 1983-05-13 1984-11-28 Taiyo Kagaku Kk トコフエロ−ル乳化物
US4725442A (en) 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
US4622219A (en) 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
JPS607418U (ja) 1983-06-28 1985-01-19 株式会社デンソー 歯付スラストワツシヤをもつ軸受装置
US4891225A (en) 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4630019A (en) 1984-09-28 1986-12-16 Westinghouse Electric Corp. Molded case circuit breaker with calibration adjusting means for a bimetal
US4725852A (en) 1985-05-09 1988-02-16 Burlington Industries, Inc. Random artificially perturbed liquid apparatus and method
US4780320A (en) 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
ATE107857T1 (de) 1986-06-10 1994-07-15 Euro Celtique Sa Zusammensetzung mit kontrollierter freisetzung von dihydrocodein.
US4861598A (en) 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4970075A (en) 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
GB8626098D0 (en) 1986-10-31 1986-12-03 Euro Celtique Sa Controlled release hydromorphone composition
US5234520A (en) 1987-03-20 1993-08-10 Morgan Adhesives Co. Method of making an adhesive construction
US5391381A (en) 1987-06-25 1995-02-21 Alza Corporation Dispenser capable of delivering plurality of drug units
US4795641A (en) 1987-08-20 1989-01-03 Eastman Kodak Company Polymer blends having reverse phase morphology for controlled delivery of bioactive agents
US5350741A (en) 1988-07-30 1994-09-27 Kanji Takada Enteric formulations of physiologically active peptides and proteins
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US4987893A (en) 1988-10-12 1991-01-29 Rochal Industries, Inc. Conformable bandage and coating material
US5324520A (en) 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
GB8926612D0 (en) 1989-11-24 1990-01-17 Erba Farmitalia Pharmaceutical compositions
IT1240643B (it) 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
US5110685A (en) 1990-05-18 1992-05-05 Exxon Chemical Patents, Inc. Low friction, abrasion resistant polymer coating
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
EP0539559A1 (en) 1991-04-03 1993-05-05 Eastman Kodak Company HIGH DURABILITY MASK FOR DRY ETCHING OF GaAs
JP3313124B2 (ja) 1991-07-31 2002-08-12 森下仁丹株式会社 親水性物質を内容物とするシームレスカプセルおよびその製法
JPH06510046A (ja) 1991-08-26 1994-11-10 アボツト・ラボラトリーズ 治療薬の舌下または頬投与のための組成物及び方法
US5487898A (en) 1991-08-26 1996-01-30 Abbott Laboratories Compositions and method for the sublingual or buccal administration therapeutic agents
YU87892A (sh) 1991-10-01 1995-12-04 Eli Lilly And Company Lilly Corporate Center Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu
IL103275A0 (en) 1991-10-01 1993-02-21 Lilly Co Eli Injectable extended release formulations and methods
AU2605592A (en) 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
ES2136624T3 (es) 1991-10-21 1999-12-01 Peptech Limited Implante biocompatible para regular la ovulacion en yeguas.
US5656295A (en) 1991-11-27 1997-08-12 Euro-Celtique, S.A. Controlled release oxycodone compositions
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
AU3125193A (en) 1991-12-05 1993-06-28 Pitman-Moore, Inc. A carbohydrate glass matrix for the sustained release of a therapeutic agent
EP0616526A1 (en) 1991-12-11 1994-09-28 The Procter & Gamble Company Cetylpyridinium chloride and domiphen bromide in organic solvent
US5478577A (en) 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
ZA932272B (en) 1992-03-30 1993-10-19 Alza Corp Viscous suspensions of controlled-release drug particles
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
AU683022B2 (en) 1992-09-10 1997-10-30 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
SK74495A3 (en) 1993-01-06 1997-01-08 Kinerton Ltd Ionic molecular conjugates of biodegradable polyesters with bioactive polypeptides and a method of preparation thereof
US5340572A (en) 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
DE69413955T2 (de) 1993-03-17 1999-04-01 Minnesota Mining And Mfg. Co., Saint Paul, Minn. Aerosolzusammensetzung enthaltend einen aus ester-, amid- oder merkaptoester- derivat dispergiermittel
US6042811A (en) 1993-03-17 2000-03-28 3M Innovative Properties Company Aerosol formulation containing a diol-diacid derived dispersing aid
DK44193D0 (da) 1993-04-20 1993-04-20 Euromed I S Saarforbinding og klaebemiddel til en saarforbinding eller lignende
IL110014A (en) 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
JP3257750B2 (ja) 1993-07-20 2002-02-18 エチコン・インコーポレーテツド ε−カプロラクトンおよびラクチドの液状コポリマー
US5879705A (en) 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
TW282403B (lt) 1993-08-26 1996-08-01 Takeda Pharm Industry Co Ltd
WO1995009613A1 (en) 1993-10-04 1995-04-13 Mark Chasin Controlled release microspheres
AU681231B2 (en) 1993-12-29 1997-08-21 Intarcia Therapeutics, Inc. Methods and compositions for the treatment of a host with a cellular proliferative disease
BR9507313A (pt) 1994-04-08 1997-10-07 Atrix Lab Inc Composição liquida de liberação adequada para a formação de um implante de liberação controlada sistema polimérico curativo filmico microporoso biodegradável precursor de implante de liberação controlada para a implantação em um indivíduo polímero termoplástico solvente orgánico composicão de pré-polimero liquido componente de liberação controlada agente ativo uso da composição liquida de liberação e processos para forma um implante microporoso de liberação prolongada e para liberar um agente ativo em um individuo
US5633000A (en) 1994-06-23 1997-05-27 Axxia Technologies Subcutaneous implant
DK0782569T3 (da) 1994-09-23 2002-07-22 Darwin Discovery Ltd Racemiseringsfremgangsmåde anvendt ved fremstilling af levobupivacain og analoger deraf
US5599852A (en) 1994-10-18 1997-02-04 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
ATE245629T1 (de) 1994-10-25 2003-08-15 Darwin Discovery Ltd Kristallisierung von levobupivacaine und deren analogen
CA2200356C (en) 1994-10-25 2007-07-31 Graham Anthony Charles Frampton Process for preparing levobupivacaine and analogues thereof
US6384227B2 (en) 1995-01-18 2002-05-07 Darwin Discovery Ltd. Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
GB9501071D0 (en) 1995-01-18 1995-03-08 Chiroscience Ltd Racemisation
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
CN1225230C (zh) 1995-06-07 2005-11-02 南方生物系统公司 高粘度液体受控输送体系
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US5968542A (en) * 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
DE69632569T2 (de) 1995-06-09 2005-08-18 Euroceltique S.A. Formulierungen und verfahren für eine verlängerte lokalanästhesie
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
EP0877599B1 (en) 1996-02-02 2003-03-26 Alza Corporation Sustained delivery of leuprolide using an implantable system
US6245351B1 (en) 1996-03-07 2001-06-12 Takeda Chemical Industries, Ltd. Controlled-release composition
EP0954301A4 (en) 1996-06-24 2006-03-08 Euro Celtique Sa SAFE METHODS OF LOCAL ANESTHESIA
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US5747051A (en) 1996-09-27 1998-05-05 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing an amide of a hydroxy fatty acid and a retinoid
US6572880B2 (en) 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
US6479074B2 (en) 1996-10-24 2002-11-12 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
PT959873E (pt) 1996-12-20 2006-07-31 Alza Corp Composicao de gel e metodos
US6203813B1 (en) 1997-01-13 2001-03-20 Lance L. Gooberman Pharmaceutical delivery device and method of preparation therefor
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
DE19714765A1 (de) 1997-04-10 1998-10-15 Merck Patent Gmbh Verwendung von niedermolekularen, oligomeren Estern von alpha-Hydroxysäuren und/oder aromatischen o-Hydroxysäuren in kosmetischen Formulierungen
US5919473A (en) 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
US5840329A (en) 1997-05-15 1998-11-24 Bioadvances Llc Pulsatile drug delivery system
US6051558A (en) 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
JP3979783B2 (ja) 1997-07-29 2007-09-19 アルコン ラボラトリーズ インコーポレイテッド ガラクトマンナンポリマー及びホウ酸塩を含む眼科組成物
EP1032390B1 (en) 1997-11-19 2003-11-12 Darwin Discovery Limited Anaesthetic formulation
RU2180557C2 (ru) * 1998-06-26 2002-03-20 Казахский Государственный национальный университет им. Аль-Фараби Анестезирующий состав пролонгированного действия
IL140420A0 (en) 1998-06-29 2002-02-10 Pharmaceuticals Applic Associa Methods and transdermal compositions for pain relief
US6312717B1 (en) 1998-07-07 2001-11-06 Bristol-Myers Squibb Company Method for treatment of anxiety and depression
DE19858891A1 (de) 1998-12-19 2000-06-21 Merck Patent Gmbh Verbesserte Knochensiegel
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
IL146567A0 (en) * 1999-06-04 2002-07-25 Skyepharma Inc Oil-core particles containing a hydrophobic core material and hydrophobic drug and method for the preparation thereof
AU5025300A (en) 1999-06-18 2001-01-09 Southern Biosystems, Inc. Compositions for controlled release of the hormone gnrh and its analogs
EP1738749A1 (en) * 1999-12-23 2007-01-03 Pfizer Products Inc. Pharmaceutical compositions providing enhanced drug concentrations
ES2283394T3 (es) 2000-01-11 2007-11-01 Bertex Pharma Gmbh Kit para implantacion que contiene una fase de soporte y un disolvente.
BR0002246A (pt) 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
IL152360A0 (en) 2000-04-19 2003-05-29 Genentech Inc Sustained release formulations
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
WO2002010436A2 (en) 2000-07-28 2002-02-07 The Brigham And Women's Hospital, Inc. Prognostic classification of breast cancer
FR2814308B1 (fr) 2000-09-15 2003-03-14 France Telecom Procede de gestion de l'usage d'une ligne de telecommunication et systeme de mise en oeuvre
KR100968128B1 (ko) 2000-10-30 2010-07-06 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
US20030152637A1 (en) 2001-01-25 2003-08-14 Mark Chasin Local anesthetic, and method of use
PT1397155E (pt) 2001-06-21 2015-12-07 Genentech Inc Formulação de libertação sustentada
JP5078217B2 (ja) * 2001-11-14 2012-11-21 デュレクト コーポレーション 注入可能なデポー組成物およびそれらの使用
FR2838349B1 (fr) 2002-04-15 2004-06-25 Laurence Paris Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication
AU2003240493B2 (en) 2002-05-31 2008-06-12 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Implantable polymeric device for sustained release of buprenorphine
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040109893A1 (en) 2002-06-25 2004-06-10 Guohua Chen Sustained release dosage forms of anesthetics for pain management
JP4417039B2 (ja) 2002-06-28 2010-02-17 太陽化学株式会社 水中油滴型乳化組成物
AU2003252694A1 (en) 2002-07-26 2004-02-16 Mikasa Seiyaku Co., Ltd. External preparation
PL375603A1 (en) 2002-10-25 2005-12-12 Pfizer Products Inc. Depot formulations of arylheterocyclic active agents in the form of a suspension
PL377679A1 (pl) 2002-10-25 2006-02-06 Pfizer Products Inc. Nowe preparaty typu depot do wstrzykiwania
CA2779723C (en) 2002-12-13 2014-03-25 Durect Corporation Oral drug delivery system
JP2006512370A (ja) 2002-12-19 2006-04-13 アルザ・コーポレーション 安定な非水性単相ゲル、および植込み型デバイスから送達するためのその配合物
DE10312346A1 (de) 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10322469A1 (de) 2003-05-19 2004-12-16 Bayer Healthcare Ag Heterocyclische Verbindungen
WO2005048742A1 (en) 2003-11-14 2005-06-02 Eastman Chemical Company Sucrose acetate isobutyrate formulation
US20050106304A1 (en) 2003-11-14 2005-05-19 Cook Phillip M. Sucrose acetate isobutyrate formulation
US20050232876A1 (en) 2004-04-19 2005-10-20 Robin Lynn Minga Skin care compositions
US20080023261A1 (en) 2004-05-14 2008-01-31 Yanmar Co., Ltd. Noise Proof Structure of Cabin
US20050266087A1 (en) 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
PL2415484T3 (pl) 2004-09-17 2014-11-28 Durect Corp Kompozycja znieczulająca miejscowo o przedłużonym uwalnianiu zawierająca SAIB
US20060263433A1 (en) 2005-02-03 2006-11-23 Ayer Rupal A Suspension formulation of interferon
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
JP5194273B2 (ja) 2007-09-20 2013-05-08 三菱電機株式会社 半導体装置
SE531980C2 (sv) 2008-01-17 2009-09-22 Avtech Sweden Ab Flygstyrningsförfarande samt datorprogram och datorprogramprodukt för att genomföra förfarandet

Also Published As

Publication number Publication date
EP3103477A1 (en) 2016-12-14
US20160235726A1 (en) 2016-08-18
DK2415484T3 (da) 2014-09-22
MX2007002962A (es) 2008-03-05
SI2767292T1 (sl) 2017-01-31
DK1809329T3 (da) 2012-04-02
HRP20120254T1 (hr) 2012-04-30
SI2415484T1 (sl) 2014-10-30
WO2006033948A2 (en) 2006-03-30
EA200700653A1 (ru) 2007-10-26
EA014852B1 (ru) 2011-02-28
US8753665B2 (en) 2014-06-17
NZ553369A (en) 2010-11-26
BRPI0515372B8 (pt) 2021-05-25
KR20070059148A (ko) 2007-06-11
KR101492361B1 (ko) 2015-02-11
JP2008513467A (ja) 2008-05-01
ES2496765T3 (es) 2014-09-19
KR101351771B1 (ko) 2014-02-17
JP2009073839A (ja) 2009-04-09
US20170216267A1 (en) 2017-08-03
US20190231762A1 (en) 2019-08-01
RS52198B (en) 2012-10-31
HUE032040T2 (en) 2017-09-28
CY1118360T1 (el) 2017-06-28
KR20130136595A (ko) 2013-12-12
GEP20094831B (en) 2009-11-25
EP1809329B1 (en) 2011-12-21
NO20071914L (no) 2007-06-15
US8153661B2 (en) 2012-04-10
US8153149B2 (en) 2012-04-10
AU2005287175A1 (en) 2006-03-30
US20080167630A1 (en) 2008-07-10
BRPI0515372B1 (pt) 2020-10-06
CA2581287C (en) 2015-08-25
PT2415484E (pt) 2014-09-19
ATE537844T1 (de) 2012-01-15
HK1201437A1 (en) 2015-09-04
DK2767292T3 (en) 2016-12-19
EA201001885A1 (ru) 2011-12-30
WO2006033948A3 (en) 2006-06-08
BRPI0515372A (pt) 2008-07-22
ES2602273T3 (es) 2017-02-20
JP5285275B2 (ja) 2013-09-11
IL181474A0 (en) 2007-07-04
JP5285374B2 (ja) 2013-09-11
PT1809329E (pt) 2012-03-29
EP2415484B1 (en) 2014-06-18
CY1112625T1 (el) 2016-02-10
EP2767292A1 (en) 2014-08-20
PL2415484T3 (pl) 2014-11-28
EP2767292B1 (en) 2016-08-24
NO342596B1 (no) 2018-06-18
US20150111924A1 (en) 2015-04-23
AU2005287175B2 (en) 2011-12-01
CA2581287A1 (en) 2006-03-30
US20130289069A1 (en) 2013-10-31
US20090036490A1 (en) 2009-02-05
US20110009451A1 (en) 2011-01-13
ES2378671T3 (es) 2012-04-16
IL181474A (en) 2014-05-28
EP2415484A1 (en) 2012-02-08
PT2767292T (pt) 2016-11-23
US20180256553A1 (en) 2018-09-13
EP1809329A2 (en) 2007-07-25
US8846072B2 (en) 2014-09-30
PL1809329T3 (pl) 2012-08-31

Similar Documents

Publication Publication Date Title
HK1201437A1 (en) Sustained local anesthetic composition containing saib saib
TW200800967A (en) Benzimidazole thiophene compounds
TW200621737A (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
IL193024A0 (en) Levetiracetam formulations and methods for their manufacture
HK1154777A1 (en) Lipoprotein lipase-activating compositions comprising benzene derivatives
WO2005112633A3 (en) Compounds and compositions for delivering active agents
MX2010004487A (es) Derivados lactamicos sustituidos y sus usos para glaucoma e hipertension ocular.
NO20064808L (no) Orale matrixformuleringer med licarbazepin
WO2006134021A3 (en) Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
WO2007133944A3 (en) Topical administration of acyclovir
TW200626158A (en) Naphthaline derivatives
NO20064783L (no) Opplosningstabeletter med licarbazepin
WO2007121471A3 (en) Dialkyl ether delivery agents
EA200602017A1 (ru) КОМПОЗИЦИЯ ДЛЯ АЭРОЗОЛЬНОЙ ИНГАЛЯЦИИ β-АГОНИСТОВ
MX2008002272A (es) Compuestos de ciclopropilo y composiciones para suministrar agentes activos.
WO2006076598A3 (en) Bicyclic heterocycles as cannabinoid receptor modulators
WO2006076568A3 (en) Thiazolopyridines as cannabinoid receptor modulators
TW200610526A (en) Novel hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents
MY137747A (en) Nasal pharmaceutical piribedil composition
TNSN06299A1 (en) Oral matrix formulations comprising licarbazepine
UA102403C2 (ru) Композиция для перорального введения
TW200642686A (en) Aporphine or secoaporphine compounds for treatment of diabetes
PL1803441T3 (pl) Farmaceutyczne formulacje fenofibratu o polepszonej biodostępności
TW200731964A (en) Pharmaceutical formulations of fenofibrate having improved bioavailability