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KR970706061A - 캡슐화된 활성 물질 및 이의 제조방법(encapsulated active materials and method for preparing same) - Google Patents

캡슐화된 활성 물질 및 이의 제조방법(encapsulated active materials and method for preparing same)

Info

Publication number
KR970706061A
KR970706061A KR1019970701949A KR19970701949A KR970706061A KR 970706061 A KR970706061 A KR 970706061A KR 1019970701949 A KR1019970701949 A KR 1019970701949A KR 19970701949 A KR19970701949 A KR 19970701949A KR 970706061 A KR970706061 A KR 970706061A
Authority
KR
South Korea
Prior art keywords
coating
active substance
process according
dimethylurea
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019970701949A
Other languages
English (en)
Inventor
드와이트 케이 호프만
데이비드 브이 델라
헤르만 웨이드 쉴라메우스
Original Assignee
그레이스 스티븐 에스
더 다우 케미칼 캄파니
스프렌셀 존
싸우스웨스트 리써치 인스티튜트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 그레이스 스티븐 에스, 더 다우 케미칼 캄파니, 스프렌셀 존, 싸우스웨스트 리써치 인스티튜트 filed Critical 그레이스 스티븐 에스
Publication of KR970706061A publication Critical patent/KR970706061A/ko
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Paints Or Removers (AREA)
  • Steroid Compounds (AREA)

Abstract

활성 물질과 비혼화성인 코팅제안에 캡슐화된 활성 물질을, 코팅제는 용해시키지 않고 코팅제의 표면에 있는 잔여의 활성 물질을 용해시키는 용매와 접촉시킨다. 결과로 생성되는 캡슐화된 물질은 용매와 접촉되지 않은 물질과 비교시 향상된 안정성을 갖는다.

Description

캡슐화된 활성 물질 및 이의 제조방법(ENCAPSULATED ACTIVE MATERIALS AND METHOD FOR PREPARING SAME)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. a) 코팅제를 용융시키기에 충분한 온도에서 활성 물질을 코팅제중에 분산시키는 단계; b) 코팅제가 산제된 활성 물질의 소적(droplet)을 형성하는 단계; c) 소적을 냉각시켜 코팅제를 고화시키는 단계; 및 d) 활성물질은 용해시키나 코팅제는 용해시키지 않는 용매와 소적을 접촉시켜 코팅제의 표면으로부터 활성 물질을 제거하는 단계를 포함하는, 활성 물질을 그와 비혼화성이고 주위 온도보다 높은 융점을 갖는 코팅제안에 캡슐화시키는 방법.
  2. 제1항에 있어서, 단계 a)에서, 활성 물질을 용융시키기에 충분한 온도에서 활성 물질을 코팅제중에 분산시키고; 단계 b), c), 및 d)에서, 소적이 미소구인 방법.
  3. 제1항 또는 제2항에 있어서, 코팅제가 석유- 유도된 알칸 탄화수소 왁스, 폴리에틸렌 왁스, 폴리에틸렌-알켄 공중합체 왁스, 하이드록실 또는 카복실 그룹을 함유하는 산화된 탄화수소 왁스, 폴리에스테르, 또는 폴리아미드인 방법.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, 활성 물질이 7O 내지 200℃ 범위의 융점을 갖는 우레아 또는 이미다졸인 방법.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서, 용매가 물, 또는 100℃ 미만의 비점을 갖는 알콜 또는 케톤인 방법.
  6. 제1항 내지 제5항 중 어느 한 항에 있어서, 활성 물질이 3-페닐-1, 1-디메틸우레아; 3-(4-클로로페닐)-1, 1-디메틸우레아; 3-(3,4-디클로로페닐)-1, 1-디메틸우레아; 1, 1'-(4-메틸-m-페닐렌)비스(3,3'-디메틸우레아) ; 3-이소메틸디메틸우레아-3,5,5-트리메틸사이클로헥실디메틸우레아 : 4,4'-메틸렌비스(페닐디메틸우레아) ; 2-메틸-N-페닐-1H-이미다졸-1-카복스아미드, 또는 2-메틸이미다졸인 방법.
  7. 제1항 내지 제6항 중 어느 한 항에 있어서, 경화 가속제가 3-페닐-1,1-디메틸우레아 또는 2-메틸이미다졸인 방법.
  8. 제1항 내지 제7항 중 어느 한 항에 있어서, 코팅제가 1000 내지 2000돌턴(Dalton) 범위의 분자량을 갖는 폴리에틸렌 왁스인 방법.
  9. 제1항 내지 제8항 중 어느 한 항에 있어서, 용매가 물, 아세톤, 메탄올, 에탄올, 또는 이소프로판올인 방법.
  10. 제1항 내지 제9항 중 어느 한 항에 있어서, 용매가 아세톤인 방법.
  11. 표면에 활성 물질이 없도록 표면이 활성 물질용 용매로 접촉된, 코팅제안에 미소캡슐화된 활성 물질을 포함하는 미소구.
  12. 제11항에 있어서, 활성 물질이 3-페닐-1,1-디메틸우레아 또는 2-메틸이미다졸이고, 코팅제가 1000 내지 2000돌턴(Dalton) 범위의 분자량을 갖는 폴리에틸렌 왁스인 미소구.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970701949A 1994-09-26 1995-09-11 캡슐화된 활성 물질 및 이의 제조방법(encapsulated active materials and method for preparing same) Ceased KR970706061A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/311,818 US5601761A (en) 1994-09-26 1994-09-26 Encapsulated active materials and method for preparing same
US08/311,818 1994-09-26
PCT/US1995/011457 WO1996009883A1 (en) 1994-09-26 1995-09-11 Encapsulated active materials and method for preparing same

Publications (1)

Publication Number Publication Date
KR970706061A true KR970706061A (ko) 1997-11-03

Family

ID=23208627

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970701949A Ceased KR970706061A (ko) 1994-09-26 1995-09-11 캡슐화된 활성 물질 및 이의 제조방법(encapsulated active materials and method for preparing same)

Country Status (11)

Country Link
US (1) US5601761A (ko)
EP (1) EP0804285B1 (ko)
JP (1) JPH10511596A (ko)
KR (1) KR970706061A (ko)
AT (1) ATE182486T1 (ko)
AU (1) AU704084B2 (ko)
BR (1) BR9509179A (ko)
CA (1) CA2200745A1 (ko)
DE (1) DE69511117T2 (ko)
MX (1) MX9702309A (ko)
WO (1) WO1996009883A1 (ko)

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GB9623878D0 (en) 1996-11-15 1997-01-08 Marlit Ltd Bonding materials
WO1999055753A1 (en) * 1998-04-27 1999-11-04 The Dow Chemical Company Cure on demand adhesives for assembling shoe soles
DE69933206T2 (de) 1998-04-27 2007-09-06 The Dow Chemical Company, Midland Bei bedarf härtbare klebstoffe und bei bedarf härtbaren klebstoff enthaltendes fenstermodul
CA2330472C (en) * 1998-04-27 2007-09-04 The Dow Chemical Company Encapsulated active materials
AU2043601A (en) 1999-12-20 2001-07-03 3M Innovative Properties Company Ambient-temperature-stable, one-part curable epoxy adhesive
MXPA03002222A (es) * 2002-03-28 2004-10-29 Rohm & Haas Polvos de recubrimiento, metodos para su elaboracion y articulos formados a partir de los mismos.
EP1592760A4 (en) * 2003-01-31 2009-08-12 Smithkline Beecham Corp AS FIXED DISPERSIONS, COMPOSITIONS
US20040185170A1 (en) * 2003-03-21 2004-09-23 Shubha Chungi Method for coating drug-containing particles and formulations and dosage units formed therefrom
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
JP2007513145A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 医薬用多微粒子の製造方法
BRPI0416535A (pt) * 2003-12-04 2007-01-09 Pfizer Prod Inc processo de congelamento por vaporização empregando um extrusor para preparar composições de azitromicina de multiparticulado contendo preferivelmente um poloxámero e um glicerìdeo
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
RU2006119453A (ru) * 2003-12-04 2007-12-20 Пфайзер Продактс Инк. (Us) Получение посредством основанных на применении жидкостей способов лекарственные формы азитромицина с большим количеством частиц
US9693967B2 (en) * 2005-09-07 2017-07-04 Southwest Research Institute Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US7261529B2 (en) * 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US7758778B2 (en) * 2005-09-07 2010-07-20 Southwest Research Institute Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US7842146B2 (en) * 2007-01-26 2010-11-30 Dow Global Technologies Inc. Ultrasonic energy for adhesive bonding
WO2013116416A1 (en) 2012-02-02 2013-08-08 Arkema Inc. Improved shelf life of polyol blends containing halogenated olefins by encapsulation of active components
US20220195247A1 (en) 2019-03-28 2022-06-23 3M Innovative Properties Company Structural bonding tape with epoxide microcapsules

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Also Published As

Publication number Publication date
EP0804285B1 (en) 1999-07-28
JPH10511596A (ja) 1998-11-10
BR9509179A (pt) 1997-12-23
US5601761A (en) 1997-02-11
EP0804285A1 (en) 1997-11-05
DE69511117T2 (de) 1999-11-25
WO1996009883A1 (en) 1996-04-04
AU3629095A (en) 1996-04-19
AU704084B2 (en) 1999-04-15
MX9702309A (es) 1998-04-30
DE69511117D1 (de) 1999-09-02
ATE182486T1 (de) 1999-08-15
CA2200745A1 (en) 1996-04-04

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