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KR950700052A - 속용정(Fast soluble tablet) - Google Patents

속용정(Fast soluble tablet)

Info

Publication number
KR950700052A
KR950700052A KR1019940702813A KR19940702813A KR950700052A KR 950700052 A KR950700052 A KR 950700052A KR 1019940702813 A KR1019940702813 A KR 1019940702813A KR 19940702813 A KR19940702813 A KR 19940702813A KR 950700052 A KR950700052 A KR 950700052A
Authority
KR
South Korea
Prior art keywords
tablet
dissolution rate
water
fast
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019940702813A
Other languages
English (en)
Other versions
KR100286505B1 (ko
Inventor
고이치 나카미치
쇼고 이즈미
히로유키 야스우라
Original Assignee
아만 히데아키
니뽄 신야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13406427&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR950700052(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 아만 히데아키, 니뽄 신야쿠 가부시키가이샤 filed Critical 아만 히데아키
Publication of KR950700052A publication Critical patent/KR950700052A/ko
Application granted granted Critical
Publication of KR100286505B1 publication Critical patent/KR100286505B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명의 목적은 특수한 제제 기술에 의하지 않고, 간편한 방법으로 제조한 구강내에서 빠르게 용해되는 정제(속용정)을 제공하는 것이다.
본 발명은 ① 물에 대한 용해 속도가 빠른 의약품 첨가물을 정제 구성 성분의 주성분으로 하는 것, 및 ② 의약품을 함유하는 정제를 습식 과립화법으로 제조하는 과정에서, 압축 성형시에 물에 대한 용해 속도가 빠른 의약품 첨가물과 의약품과의 혼련물을 건조전에 압축 성형시키는 것을 특징으로 하는 속용정에 관한 것이다.
본 발명의 속용정은 종래의 정제 제조방법을 일부 변경하는 것만으로 제조할 수 있으며, 또한, 충분한 물리 화학적 안정성을 갖는 것이다.

Description

속용정(Fast soluble tablet)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예 1의 본 발명의 속용정, 비교예 1의 정제 및 실시예 1의 건조시키지 않은 정제 각각에 대해 측정한 인장 강도 및 구강내 용해 시간과 성형 압력과의 관계를 나타낸다. 제2도는 실시예 2의 본 발명의 속용정에 대해 측정한 인장 강도 및 구강내 용해 시간과 성형 압력과의 관계를 나타낸다. 제3도는 실시예 3의 본 발명의 속용정에 대해 측정한 인장 강도 및 구강내 용해 시간과 성형 압력과의 관계를 나타낸다. 제4도는 실시예 4의 본 발명의 속용정, 비교예 1의 정제 및 실시예 1의 건조시키지 않은 정제 각각에 대해 측정한 인장 강도 및 구강내 용해 시간과 성형 압력과의 관계를 나타낸다.

Claims (6)

  1. ① 물에 대한 용해 속도가 빠른 의약품 첨가물을 정제 구성 성분의 주성분으로 하는 것, 및 ② 의약품을 함유하는 정제를 습식 과립화법으로 제조하는 과정에서, 압축 성형시에 물에 대한 용해 속도가 빠른 의약품 첨가물과 의약품과의 혼련물을 건조전에 압축 성형시키는 것을 특징으로 하는 속용정.
  2. 제1항에 있어서, 물에 대한 용해 속도가 빠른 의약품 첨가물이 당 알콜 또는 당인 속용정.
  3. 제2항에 있어서, 상기 당 알콜이 크실리톨인 속용정.
  4. 제3항에 있어서, 상기 압축 성형 압력이 50 내지 300kg인 속용정.
  5. 제1항에 있어서, 물에 대한 용해 속도가 빠른 의약품 첨가물이 크실리톨과 유당과의 혼합물인 속용정.
  6. 제1항에 있어서, 물에 대한 용해 속도가 빠른 의약품 첨가물이 크실리톨과 만니톨과의 혼합물인 속용정.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940702813A 1992-02-18 1993-02-17 속용정 Expired - Fee Related KR100286505B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP92-69565 1992-02-18
JP6956592 1992-02-18
PCT/JP1993/000192 WO1993015724A1 (en) 1992-02-18 1993-02-17 Fast soluble tablet

Publications (2)

Publication Number Publication Date
KR950700052A true KR950700052A (ko) 1995-01-16
KR100286505B1 KR100286505B1 (ko) 2001-04-16

Family

ID=13406427

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702813A Expired - Fee Related KR100286505B1 (ko) 1992-02-18 1993-02-17 속용정

Country Status (7)

Country Link
US (1) US5837285A (ko)
EP (1) EP0627218B1 (ko)
KR (1) KR100286505B1 (ko)
AT (1) ATE210968T1 (ko)
CA (1) CA2130487A1 (ko)
DE (2) DE627218T1 (ko)
WO (1) WO1993015724A1 (ko)

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Also Published As

Publication number Publication date
US5837285A (en) 1998-11-17
CA2130487A1 (en) 1993-08-19
ATE210968T1 (de) 2002-01-15
EP0627218B1 (en) 2001-12-19
DE69331378D1 (de) 2002-01-31
WO1993015724A1 (en) 1993-08-19
EP0627218A4 (en) 1995-06-14
EP0627218A1 (en) 1994-12-07
KR100286505B1 (ko) 2001-04-16
DE627218T1 (de) 1995-08-24

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