KR950008684A - 아포리포프로틴 b로 이루어진 엔도텔린 전환효소 - Google Patents
아포리포프로틴 b로 이루어진 엔도텔린 전환효소 Download PDFInfo
- Publication number
- KR950008684A KR950008684A KR1019940023754A KR19940023754A KR950008684A KR 950008684 A KR950008684 A KR 950008684A KR 1019940023754 A KR1019940023754 A KR 1019940023754A KR 19940023754 A KR19940023754 A KR 19940023754A KR 950008684 A KR950008684 A KR 950008684A
- Authority
- KR
- South Korea
- Prior art keywords
- apolipoprotein
- converting enzyme
- endothelin converting
- enzyme consisting
- endothelin
- Prior art date
Links
- 101710095342 Apolipoprotein B Proteins 0.000 title claims abstract 8
- 102100040202 Apolipoprotein B-100 Human genes 0.000 title claims abstract 8
- 102000048186 Endothelin-converting enzyme 1 Human genes 0.000 title claims abstract 7
- 108030001679 Endothelin-converting enzyme 1 Proteins 0.000 title claims abstract 7
- 239000002857 endothelin converting enzyme inhibitor Substances 0.000 claims abstract 2
- 238000012216 screening Methods 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 2
- 229940122783 Endothelin converting-enzyme inhibitor Drugs 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6497—Endothelin-converting enzyme (3.4.24.71)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24071—Endothelin-converting enzyme 1 (3.4.24.71)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
본 발명은 엔도텔린 전환효소로서의 아포리포프로틴 B의 용도에 관한 것이다. 아포리포프로틴 B는 그 자체가 엔도텔린 전환효소 활성을 가지며, 엔도텔린 전환효소 억제제를 선별하는데 있어서 유용하다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 아포리포프로틴 B로 이루어진 엔도텔린 전환효소.
- 제1항에 있어서, 아포리포프로틴 B가 사람으로부터 수득된 것인 엔도텔린 전환효소.
- 아포리포프로틴 B로 이루어진 엔도텔린 전환효소를 대조 효소로서 사용함을 포함하는, 엔도텔린 전환효소 억제제의 선별방법.
- 제3항에 있어서, 아포리포프로틴 B가 사람으로부터 수득된 것인 방법.
- 엔도텔린 전환효소로서의 아포리포프로틴 B의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP93-234650 | 1993-09-21 | ||
| JP23465093 | 1993-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950008684A true KR950008684A (ko) | 1995-04-19 |
Family
ID=16974349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940023754A KR950008684A (ko) | 1993-09-21 | 1994-09-17 | 아포리포프로틴 b로 이루어진 엔도텔린 전환효소 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5468623A (ko) |
| EP (1) | EP0644261B1 (ko) |
| KR (1) | KR950008684A (ko) |
| DE (1) | DE69427508T2 (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063592A (en) * | 1998-11-13 | 2000-05-16 | New York Blood Center, Inc. | Kell protein proteolytic activity |
| US7741431B2 (en) * | 2005-02-01 | 2010-06-22 | The United States Of America As Represented By The Secretary Of The Army | Liposomes containing novel targeting and/or fusogenic peptides, preparations containing them and therapeutic use thereof |
| US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| AU2007233320B2 (en) | 2006-04-04 | 2013-12-12 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| AU2010259022B2 (en) | 2009-06-08 | 2016-05-12 | Singulex, Inc. | Highly sensitive biomarker panels |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2070820T3 (es) * | 1986-08-06 | 1995-06-16 | Scripps Clinic Res | Anticuerpos monoclonales especificos de la apolipoproteina b, producidos por dos nuevos hibridomas. |
| EP0347915A3 (en) * | 1988-06-23 | 1991-03-20 | The Rockefeller University | Method and agents for inhibiting low density lipoprotein synthesis |
| US5220006A (en) * | 1990-10-23 | 1993-06-15 | The United States Of America As Represented By The Department Of Health And Human Services | Identification of a suppressor of atherogenic apolipoprotein |
| CA2100355A1 (en) | 1991-02-04 | 1992-08-05 | Lynne H. Parker Botehlo | Endothelin converting enzyme |
-
1994
- 1994-09-17 KR KR1019940023754A patent/KR950008684A/ko not_active Application Discontinuation
- 1994-09-20 EP EP94306867A patent/EP0644261B1/en not_active Expired - Lifetime
- 1994-09-20 DE DE69427508T patent/DE69427508T2/de not_active Expired - Fee Related
-
1995
- 1995-02-23 US US08/393,036 patent/US5468623A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0644261B1 (en) | 2001-06-20 |
| DE69427508T2 (de) | 2001-10-04 |
| EP0644261A1 (en) | 1995-03-22 |
| US5468623A (en) | 1995-11-21 |
| DE69427508D1 (de) | 2001-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE19680256T1 (de) | Kleine Inhibitor-Moleküle der Enzymaktivität von Rotamase | |
| FI942624A0 (fi) | Alfa-heteroaryylioksimetyyliketoneja interleukiini-1betaa muuttavan entsyymin inhibiittoreina | |
| ES2157470T3 (es) | Amidas arilicas y heteroarilicas de tetrahidronaftaleno, cromano, tiocromano y acidos 1,2,3,4-tetrahidroquinolin-carboxilicos que tienen actividad biologica de tipo retinoide. | |
| BR9611615A (pt) | Aril ou heteroarilamidas substituídas tendo uma atividade biológica semelhante à retinóide | |
| FI962315L (fi) | Entsyymi-inhibiittorit | |
| DE69614768D1 (de) | Emulsionsspaltung durch Mikroorganismen | |
| ATE265997T1 (de) | Substituierte tetrahydronaphthalin- und dihydronaphthalin-derivate mit einer retinoiden und/oder retinoid antagonist-ähnlichen biologischen aktivität | |
| DE69012141D1 (de) | Ortsspezifische modifikation des candida tropicalis genomes. | |
| DE69009562D1 (de) | Korrosionsinhibitor und seine Verwendung. | |
| DE69323019D1 (de) | Verbesserter Nachweis von Mikroorganismen | |
| DE69400036D1 (de) | Reinigung von Pentafluorethan. | |
| DE69535239D1 (de) | Verbrennung von organischen Abfällen | |
| DE68915112D1 (de) | Spiro-isochinolin-pyrrolidin-tetrone und Analoge davon, verwendbar als Aldosereduktase-Inhibitoren. | |
| DE69434084D1 (de) | Diagnostische anwendungen von hydrazinoadenosine | |
| ATE274273T1 (de) | Verfahren und system zur vorbeugung von unerwüschten betätigungen von ausführbaren objekten | |
| KR950008684A (ko) | 아포리포프로틴 b로 이루어진 엔도텔린 전환효소 | |
| ES2186807T3 (es) | Inhibidores de trombina. | |
| DE69421273D1 (de) | Kristallisation von 2,6-dimethylnaphthalin | |
| KR950700988A (ko) | 미생물, 이들의 제조방법 및 이들의 사용(Micro-organisms, preparation method therefor and uses thereof) | |
| KR910005885A (ko) | 단백질 c의 활성화방법 | |
| DE3778158D1 (de) | Inhibitoren von esterase produzierenden mikroorganismen zur hauptverwendung in deodorants. | |
| EP0705263A1 (en) | NOVEL CARBOCYCLIC NUCLEOSIDES USEFUL AS SELECTIVE INHIBITORS OF CYTOKINES INVOLVED IN INFLAMMATIONS | |
| EP0679051A3 (de) | Kontaktierung von Betätigungs- und Anzeigemitteln. | |
| ES2139341T3 (es) | Isocomarinas antitumorales. | |
| KR910021410A (ko) | 신규 올리고펩티드 및 안지오텐신 변환효소저해제 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19940917 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |