DE68915112D1 - Spiro-isochinolin-pyrrolidin-tetrone und Analoge davon, verwendbar als Aldosereduktase-Inhibitoren. - Google Patents

Spiro-isochinolin-pyrrolidin-tetrone und Analoge davon, verwendbar als Aldosereduktase-Inhibitoren.

Info

Publication number: DE68915112D1
Authority: DE; Germany
Prior art keywords: isoquinoline; spiro; analogues; useful; reductase inhibitors
Prior art date: 1988-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE68915112T

Other languages

English (en)

Other versions

DE68915112T2 (de

Inventor

Michael Sotirios Malamas

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

Original Assignee

American Home Products Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-20

Filing date

1989-10-19

Publication date

1994-06-09

1989-05-26 Priority claimed from US07/357,563 external-priority patent/US4927831A/en

1989-08-31 Priority claimed from GB898919736A external-priority patent/GB8919736D0/en

1989-10-19 Application filed by American Home Products Corp filed Critical American Home Products Corp

1994-06-09 Application granted granted Critical

1994-06-09 Publication of DE68915112D1 publication Critical patent/DE68915112D1/de

1994-10-06 Publication of DE68915112T2 publication Critical patent/DE68915112T2/de

2009-10-20 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE1989615112 1988-10-20 1989-10-19 Spiro-isochinolin-pyrrolidin-tetrone und Analoge davon, verwendbar als Aldosereduktase-Inhibitoren. Expired - Fee Related DE68915112T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US26043488A	1988-10-20	1988-10-20
US07/357,563 US4927831A (en)	1988-10-20	1989-05-26	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
GB898919736A GB8919736D0 (en)	1989-08-31	1989-08-31	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibators

Publications (2)

Publication Number	Publication Date
DE68915112D1 true DE68915112D1 (de)	1994-06-09
DE68915112T2 DE68915112T2 (de)	1994-10-06

Family

ID=27264666

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE1989615112 Expired - Fee Related DE68915112T2 (de)	1988-10-20	1989-10-19	Spiro-isochinolin-pyrrolidin-tetrone und Analoge davon, verwendbar als Aldosereduktase-Inhibitoren.

Country Status (7)

Country	Link
EP (1)	EP0365324B1 (de)
AU (2)	AU617541B2 (de)
DE (1)	DE68915112T2 (de)
ES (1)	ES2052019T3 (de)
GB (2)	GB2224734B (de)
HK (1)	HK168195A (de)
IE (1)	IE64498B1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU617541B2 (en) *	1988-10-20	1991-11-28	Wyeth	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
GB2252321B (en) *	1988-10-20	1993-02-24	American Home Prod	Process for preparing isoquinoline intermediates
US5045544A (en) *	1990-05-21	1991-09-03	American Home Products Corporation	N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5037831A (en) *	1990-05-21	1991-08-06	American Home Products Corporation	Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5068332A (en) *	1990-10-12	1991-11-26	American Home Products Corporation	Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) *	1990-10-12	1992-04-07	American Home Products Corporation	1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
DK0519600T3 (da) *	1991-05-22	1997-12-29	American Home Prod	Fremgangsmåde og mellemprodukt til fremstilling af isoquinolinderivater
US5169948A (en) *	1991-05-22	1992-12-08	American Home Products Corporation	Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors
TW202450B (de) *	1991-06-26	1993-03-21	Dainippon Pharmaceutical Co
US6743777B1 (en)	1992-03-19	2004-06-01	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en)	1992-03-19	2002-05-07	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
WO2000052037A1 (en)	1999-03-03	2000-09-08	Eli Lilly And Company	Echinocandin/carbohydrate complexes
JP4936595B2 (ja)	1999-03-03	2012-05-23	イーライリリーアンドカンパニー	ミセル形成界面活性剤を含有するエキノカンジン薬学的処方物
US6991800B2 (en)	2002-06-13	2006-01-31	Vicuron Pharmaceuticals Inc.	Antifungal parenteral products

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1185934A (en) *	1967-06-28	1970-03-25	Pfizer & Co C	Derivatives of 1,3(2H,4H)-Dioxoisoquinoline and preparation thereof
US4210756A (en) *	1976-10-18	1980-07-01	Pfizer Inc.	Tetrahydroquinoline hydantoins for chronic diabetic complications
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
ES8400116A1 (es) *	1981-10-13	1983-10-16	Pfizer	"un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona".
FR2525603A1 (fr) *	1982-04-27	1983-10-28	Adir	Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique
FR2544317B2 (fr) *	1983-04-12	1985-07-05	Adir	Benzoazacycloalkyl-spiro-imidazolidines et les compositions pharmaceutiques les contenant
DK277484A (da) *	1983-06-23	1984-12-24	Hoffmann La Roche	Thiazolidinderivater
AU617541B2 (en) *	1988-10-20	1991-11-28	Wyeth	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
GB2252321B (en) *	1988-10-20	1993-02-24	American Home Prod	Process for preparing isoquinoline intermediates

1989
- 1989-10-18 AU AU42983/89A patent/AU617541B2/en not_active Ceased
- 1989-10-19 IE IE336389A patent/IE64498B1/en not_active IP Right Cessation
- 1989-10-19 DE DE1989615112 patent/DE68915112T2/de not_active Expired - Fee Related
- 1989-10-19 ES ES89310762T patent/ES2052019T3/es not_active Expired - Lifetime
- 1989-10-19 EP EP89310762A patent/EP0365324B1/de not_active Expired - Lifetime
- 1989-10-19 GB GB8923622A patent/GB2224734B/en not_active Expired - Fee Related
1992
- 1992-01-24 AU AU10435/92A patent/AU635873B2/en not_active Ceased
- 1992-10-02 GB GB9220822A patent/GB2257971B/en not_active Expired - Fee Related
1995
- 1995-11-02 HK HK168195A patent/HK168195A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0365324B1 (de)	1994-05-04
ES2052019T3 (es)	1994-07-01
AU635873B2 (en)	1993-04-01
GB2224734A (en)	1990-05-16
GB9220822D0 (en)	1992-11-18
EP0365324A1 (de)	1990-04-25
GB8923622D0 (en)	1989-12-06
AU4298389A (en)	1990-04-26
HK168195A (en)	1995-11-10
GB2257971B (en)	1993-04-14
AU1043592A (en)	1992-03-19
DE68915112T2 (de)	1994-10-06
AU617541B2 (en)	1991-11-28
IE64498B1 (en)	1995-08-09
IE893363L (en)	1990-04-20
GB2224734B (en)	1993-03-03
GB2257971A (en)	1993-01-27

Publication	Publication Date	Title
DE68901836D1 (de)	1992-07-23	Drehbohrhammer.
DE68904095D1 (de)	1993-02-11	Drehbohrhammer.
FI896093A0 (fi)	1989-12-19	Varmlaminerbara, gas ogenomslaeppliga flerskiktsfolier.
ATE121741T1 (de)	1995-05-15	Piperidinyl-benzimidazole als antihistaminica.
DE69009822D1 (de)	1994-07-21	Zusammensetzung und ihre Verwendung.
DE69423679D1 (de)	2000-05-04	Kleiner, tragbarer Rehner
DE69005393D1 (de)	1994-02-03	Gas-Laser-Vorrichtung.
DE69000467D1 (de)	1992-12-24	Bis-aza-bicyclische anxiolytica und antidepressiva.
DE68915112D1 (de)	1994-06-09	Spiro-isochinolin-pyrrolidin-tetrone und Analoge davon, verwendbar als Aldosereduktase-Inhibitoren.
DE68915585D1 (de)	1994-07-07	Infrarot-Gasanalysator.
DE3881373D1 (de)	1993-07-01	Hmg-coa-reduktase-hemmer.
DE69015119D1 (de)	1995-01-26	Stabilisierte Enzym-Mischungen.
DE69020394D1 (de)	1995-08-03	Aldose-Reductase-Inhibitor.
DE68900988D1 (de)	1992-04-23	Hmg-coa-reduktase-inhibitoren.
FI941146A0 (fi)	1994-03-10	Iskulaite
DE68912476D1 (de)	1994-03-03	Substituierte Thienopyrane als blutdrucksenkendes Mittel.
DE69011337D1 (de)	1994-09-08	Polyhalodihydrodioxine und polyhalodioxole.
FI905506A0 (fi)	1990-11-06	Viskoelastisk daempare.
ATE105291T1 (de)	1994-05-15	Spiro-isochinolin-pyrrolidin-tetrone und analoge davon, verwendbar als aldosereduktaseinhibitoren.
FR2704340B1 (fr)	1997-11-28	Numériseur.
DK519289D0 (da)	1989-10-19	Mikrobiel reduktase
NO903229D0 (no)	1990-07-19	Substituerte isoksazol- og isotiazolderivater.
DE59005232D1 (de)	1994-05-11	Gaslaser.
DE68901482D1 (de)	1992-06-17	Gasverdichter.
FI922902A0 (fi)	1992-06-22	Detektorsystem foer gas.

Legal Events

Date	Code	Title	Description
1995-06-01	8364	No opposition during term of opposition
2002-09-26	8327	Change in the person/name/address of the patent owner	Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J.
2007-08-23	8339	Ceased/non-payment of the annual fee