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KR940019703A - 피리독신 5-옥소-2-피롤리돈 카르복실레이트의 제조공정 - Google Patents

피리독신 5-옥소-2-피롤리돈 카르복실레이트의 제조공정 Download PDF

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Publication number
KR940019703A
KR940019703A KR1019930005259A KR930005259A KR940019703A KR 940019703 A KR940019703 A KR 940019703A KR 1019930005259 A KR1019930005259 A KR 1019930005259A KR 930005259 A KR930005259 A KR 930005259A KR 940019703 A KR940019703 A KR 940019703A
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KR
South Korea
Prior art keywords
oxo
pyridoxine
pyrrolidone carboxylate
process according
isopropanol
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Application number
KR1019930005259A
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English (en)
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KR100257967B1 (ko
Inventor
마씨모 발다찌
Original Assignee
마시모 발다찌
라보라토리 발다찌 쏘시에떼 퍼 아찌오니
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Publication of KR940019703A publication Critical patent/KR940019703A/ko
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Publication of KR100257967B1 publication Critical patent/KR100257967B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

본 발명은 피리독신 5-옥소-2-피롤리돈 카르복길레이트의 제조를 위해 고형분말의 파리독신 염기와 피로글루타민산을 혼합하여 생성된 혼합물에 5-10% 물을 포함한 소량의 이소프로판을 첨가하는 것을 특징으로 한다.

Description

피리독신 5-옥소-2-피롤리돈 카르복실레이트의 제조공정
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명 성분물의 NMR을 나타낸 것이다,
제2도는 본 발명 성분물의 DSC를 나타낸 것이다,
제3도는 본 발명 성분물의 1R을 나타낸 것이다.

Claims (3)

  1. 하기의 구조식을 가지고 이 제조공정에 있어서:
    고형분말로써 피리독신 염기와 피로글루타민산의 동량을 완전히 혼합하여 탈이온수 5-10%를 포함하는 소량의 이소프로판올을 첨가하여 반응시키는 것을 특징으로 하는 피리독신 5-옥소-피롤리돈 카르복실레이트의 생산공정.
  2. 제1항에 있어서, 페이스트형태의 반응 생성물을 결정상태의 공형이 형성될 때까지 방치해두고, 그다음 입자형성후 가열하여 진공건조시키는 것을 특징으로 하는 공정.
  3. 제1항에 있어서, 이소프로판올에서 결정을 형성시킴으로써 정제하는 것을 특징으로 하는 공정.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930005259A 1993-02-23 1993-03-31 피리독신 5-옥소-2-피롤리돈 카르복실레이트의 제조공정 Expired - Fee Related KR100257967B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI93A000340 1993-02-23
ITMI930340A IT1263956B (it) 1993-02-23 1993-02-23 Procedimento per la preparazione di 5-oxo-2-pirrolidoncarbossilato di piridossina

Publications (2)

Publication Number Publication Date
KR940019703A true KR940019703A (ko) 1994-09-14
KR100257967B1 KR100257967B1 (ko) 2000-07-01

Family

ID=11365118

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930005259A Expired - Fee Related KR100257967B1 (ko) 1993-02-23 1993-03-31 피리독신 5-옥소-2-피롤리돈 카르복실레이트의 제조공정

Country Status (5)

Country Link
KR (1) KR100257967B1 (ko)
AT (1) AT403160B (ko)
IT (1) IT1263956B (ko)
TW (1) TW235962B (ko)
WO (1) WO1994019324A1 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105906559B (zh) * 2016-06-14 2018-08-14 成都倍特药业有限公司 一种药用级美他多辛的一步合成法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6990M (ko) * 1968-03-13 1969-05-27
FR2244466A1 (en) * 1973-06-29 1975-04-18 Dufour Claude Salts of pyridoxine with aryloxy alkanoic acids - useful as antihyperlipemic agents for oral administration
FR2260330A1 (en) * 1974-02-07 1975-09-05 Innothera Lab Sa Pyridoxine N-oxy nicotinate - hypolipaemiant and hypocholesterolemiant of good therapeutic index
FR2485372B1 (fr) * 1980-06-30 1985-08-09 Baldacci Lab Spa Composition pharmaceutique pour le traitement des etats d'intoxication alcoolique aigue a base de 5-oxo-2-pyrrolidone carboxylate de pyridoxine et procede de preparation de ce dernier
IT1131856B (it) * 1980-06-30 1986-06-25 Baldacci Lab Spa Composizione farmaceutica per il trattamento di intossicazioni alcooliche

Also Published As

Publication number Publication date
AT403160B (de) 1997-11-25
TW235962B (ko) 1994-12-11
KR100257967B1 (ko) 2000-07-01
WO1994019324A1 (en) 1994-09-01
ITMI930340A0 (it) 1993-02-23
ATA900494A (de) 1997-04-15
IT1263956B (it) 1996-09-05
ITMI930340A1 (it) 1994-08-23

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