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KR940005615A - 시클로헵트이미다졸 유도체, 그의 제조방법 및 이 화합물을 함유하는 치료제 - Google Patents

시클로헵트이미다졸 유도체, 그의 제조방법 및 이 화합물을 함유하는 치료제 Download PDF

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Publication number
KR940005615A
KR940005615A KR1019930008601A KR930008601A KR940005615A KR 940005615 A KR940005615 A KR 940005615A KR 1019930008601 A KR1019930008601 A KR 1019930008601A KR 930008601 A KR930008601 A KR 930008601A KR 940005615 A KR940005615 A KR 940005615A
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South Korea
Prior art keywords
hydrogen
compound
formula
active ingredient
isopropyl
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KR1019930008601A
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English (en)
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KR0152299B1 (ko
Inventor
츄요시 도미야마
아키라 도미야마
다카시 야나기사와
나오토 우에야마
도모유키 가와이
모토하루 소네가와
히로미 바바
마고토 하케다
Original Assignee
츄요시 도미야마
고토부키 세이야쿠 컴퍼니 리미티드
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Publication of KR940005615A publication Critical patent/KR940005615A/ko
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Publication of KR0152299B1 publication Critical patent/KR0152299B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 신규한 치료제인 다음 일반식의 시클로헵트이미다졸 유도체 또는 그의 알칼리-부가염에 관한 것이다.
상기식에서, R1은 H또는 이소프로필이고, R2는 저급알킬이며, R3는 카르복실산 또는 테트라졸 그룹이고, A 및 A1은 4- 또는 8-위치의 치환체 그룹으로서, A가 수소인 경우에 A1은 수소 또는 하이드록시 그룹이거나, A 및 A1은 옥소 그룹이며, 점선 "…"은 2개의 이중결합 또는 포화된 단일결합이다.

Description

시클로헵트미이다졸 유도체, 그의 제조방법 및 이 화합물을 함유하는 치료제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(1)의 화합물 또는 그의 염.
    상기식에서, R1은 수소 또는 이소프로필이고, R2는 저금알킬이며, R3는 카르복실 또는 테트라졸릴이고, A 및 A1은 각각 4- 또는 8- 위치의 치환기로서, A가 수소인 경우에 A1은 수소 또는 하이드록시이거나, A 및 A1은 옥소 그룸을 형성할 수 있으며, 선 …은 2개의 이중결합 또는 포화된 단일결합이다.
  2. 일반식(2)의 화합물을 일반식(3)의 화합물과 반응시킨 후, 생성된 일반식(4)의 화합물을 가수분해시키거나 탈트리틸시킴을 특징으로 하여 일반식(1)의 화합물 또는 그의 염을 제조하는 방법.
    상기식에서, R1은 수소 또는 이소프로필이고, R2는 저급알킬이며, R3는 카르복실 또는 테트라졸릴이고, A및 A1은 각각 4- 또는 8- 위치의 치환기로서, A가 수소인 경우에 A1은 수소 또는 하이드록시이거나, A및 A1은 옥소 그룹을 형성할 수 있으며, 선 …은 2개의 이중결합 또는 포화된 단일결합이고, R4는 -COOR5(여기에서, R5는 저급알킬 그룹을 나타낸다).
    X는 염소 또는 브롬이다.
  3. 활성성분으로서 일반식(1)의 화합물 또는 그의 약제학적으로 허용되는 염기와의 염을 약제학적으로 허용되는 담체와 함께 함유함을 특징으로 하는 약제학적 조성물.
    상기식에서, R1은 수소 또는 이소프로필이고, R2는 저급알킬이며, R3는 카르복실 또는 테트라졸릴이고, A 및 A1은 각각 4- 또는 8- 위치의 치환기로서, A가 수소인 경우에 A1은 수소 또는 하이드록시이거나, A 및 A1은 옥소 그룸을 형성할 수 있으며, 선 …은 2개의 이중결합 또는 포환된 단일결합을 나타낸다.
  4. 제1항에서 청구된 화합물을 활성성분으로 함유하는 고혈압 치료제.
  5. 제1항에서 청구된 화합물을 활성성분으로 함유하는 울혈성 심부전증 치료제.
  6. 제1항에서 청구된 화합물을 활성성분으로 함유하는 안압저하제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930008601A 1992-05-22 1993-05-19 시클로헵트이미다졸 유도체, 그의 제조방법 및 이 화합물을 함유하는 치료제 KR0152299B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4131142A JP2707390B2 (ja) 1992-05-22 1992-05-22 シクロヘプトイミダゾ−ル誘導体及びその製造方法並びにこれを含有する薬剤
JP131142/92 1992-05-22

Publications (2)

Publication Number Publication Date
KR940005615A true KR940005615A (ko) 1994-03-21
KR0152299B1 KR0152299B1 (ko) 1998-10-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930008601A KR0152299B1 (ko) 1992-05-22 1993-05-19 시클로헵트이미다졸 유도체, 그의 제조방법 및 이 화합물을 함유하는 치료제

Country Status (10)

Country Link
US (1) US5409947A (ko)
JP (1) JP2707390B2 (ko)
KR (1) KR0152299B1 (ko)
BE (1) BE1006419A3 (ko)
DE (1) DE4316117C2 (ko)
ES (1) ES2103161B1 (ko)
FR (1) FR2691461B1 (ko)
GB (1) GB2267089B (ko)
IT (1) IT1265077B1 (ko)
ZA (1) ZA933151B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA945190B (en) * 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
JP4316686B2 (ja) * 1994-09-05 2009-08-19 壽製薬株式会社 シクロヘプトイミダゾール誘導体
US6162922A (en) * 1998-01-30 2000-12-19 Bristol-Myers Squibb Co. Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
JP4018816B2 (ja) * 1998-09-08 2007-12-05 壽製薬株式会社 シクロヘプテノン誘導体及びその製造方法並びにそれを利用してシクロヘプトイミダゾール誘導体を製造する方法
WO2001052847A1 (en) * 2000-01-19 2001-07-26 Alteon, Inc. Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
CN100453117C (zh) * 2003-10-10 2009-01-21 索尔瓦药物有限公司 包含选择性ⅰ1咪唑啉受体激动剂和血管紧张素ⅱ受体阻断剂的药物组合物
JP4675586B2 (ja) * 2004-06-23 2011-04-27 壽製薬株式会社 高血圧症及び血清高尿酸血症の重複発症の治療のための薬剤
JP5575357B2 (ja) * 2004-07-02 2014-08-20 第一三共株式会社 組織因子産生抑制剤
AU2005297984B2 (en) 2004-10-27 2009-11-12 Daiichi Sankyo Company, Limited Benzene compound having 2 or more substituents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250554A (en) * 1989-10-24 1993-10-05 Takeda Chemical Industries, Ltd. Benzimidazole derivatives useful as angiotensin II inhibitors
US5104891A (en) * 1989-12-11 1992-04-14 G. D. Searle & Co. Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension

Also Published As

Publication number Publication date
IT1265077B1 (it) 1996-10-30
ITMI931019A0 (it) 1993-05-18
KR0152299B1 (ko) 1998-10-15
JP2707390B2 (ja) 1998-01-28
ITMI931019A1 (it) 1994-11-18
ZA933151B (en) 1993-12-06
ES2103161A1 (es) 1997-08-16
GB9310492D0 (en) 1993-07-07
DE4316117A1 (de) 1993-11-25
BE1006419A3 (fr) 1994-08-23
ES2103161B1 (es) 1998-04-01
FR2691461B1 (fr) 1994-11-10
US5409947A (en) 1995-04-25
JPH05320139A (ja) 1993-12-03
GB2267089A (en) 1993-11-24
FR2691461A1 (fr) 1993-11-26
DE4316117C2 (de) 2002-06-27
GB2267089B (en) 1995-10-04

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