[go: up one dir, main page]

KR920703634A - 염증 부위로 부터 정제된 포스포리파제 a₂의 펩타이드 저해제 - Google Patents

염증 부위로 부터 정제된 포스포리파제 a₂의 펩타이드 저해제

Info

Publication number
KR920703634A
KR920703634A KR1019920701448A KR920701448A KR920703634A KR 920703634 A KR920703634 A KR 920703634A KR 1019920701448 A KR1019920701448 A KR 1019920701448A KR 920701448 A KR920701448 A KR 920701448A KR 920703634 A KR920703634 A KR 920703634A
Authority
KR
South Korea
Prior art keywords
phospholipase
purified
peptide inhibitors
inflammatory sites
amino acid
Prior art date
Application number
KR1019920701448A
Other languages
English (en)
Other versions
KR960004772B1 (ko
Inventor
요리마사 스와
아쯔시 이마이즈미
마사히로 오까다
지에꼬 아즈마
이찌로 구도
게이조 이노우에
Original Assignee
이다가끼 히로시
데이진 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이다가끼 히로시, 데이진 가부시끼가이샤 filed Critical 이다가끼 히로시
Publication of KR920703634A publication Critical patent/KR920703634A/ko
Application granted granted Critical
Publication of KR960004772B1 publication Critical patent/KR960004772B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

염증 부위로 부터 정제된 포스포리파제 A2의 펩타이드 저해제
[도면의 간단한 설명]
제1도는 역상 HPLC에 의한 본 발명에 따른 실시예 1의 펩타이드 분별을 나타낸다.
제2도는 실시예 2에서 측정된 포스포리파제 A2에 대한 본 발명에 따른 펩타이드의 저해 활성을 나타낸다.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 서열 제1번에 나타난 아미노산 서열을 포함함을 특징으로 하는 염증부위에서 정제한 포스포리파제 A2의 펩타이드 저해제.
  2. 제1항에 있어서, 하나 이상의 아미노산 잔기가 치환, 결실 및 삽입된 것을 포함하는 아미노산 서열임을 특징으로 하는 펩타이드.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920701448A 1990-10-18 1991-10-17 염증 부위로 부터 정제된 포스포리파제 a_2의 펩타이드 저해제 KR960004772B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP90-277842 1990-10-18
JP27784290 1990-10-18
PCT/JP1991/001424 WO1992006997A1 (fr) 1990-10-18 1991-10-17 Peptide actif dans l'inhibition de la phospholipase a2 apparaissant dans une partie enflammee

Publications (2)

Publication Number Publication Date
KR920703634A true KR920703634A (ko) 1992-12-18
KR960004772B1 KR960004772B1 (ko) 1996-04-13

Family

ID=17589026

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920701448A KR960004772B1 (ko) 1990-10-18 1991-10-17 염증 부위로 부터 정제된 포스포리파제 a_2의 펩타이드 저해제

Country Status (8)

Country Link
US (1) US5374713A (ko)
EP (1) EP0506971B1 (ko)
KR (1) KR960004772B1 (ko)
AT (1) ATE138387T1 (ko)
AU (1) AU635669B2 (ko)
CA (1) CA2071910A1 (ko)
DE (1) DE69119747T2 (ko)
WO (1) WO1992006997A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100411828B1 (ko) * 2001-04-21 2003-12-24 김수열 항 염증 효과가 있는 새로운 합성 펩타이드
US20030100016A1 (en) * 2001-11-23 2003-05-29 George Jackowski Complement C3 precursor biopolymer markers predictive of Alzheimers disease

Also Published As

Publication number Publication date
DE69119747D1 (de) 1996-06-27
EP0506971A4 (en) 1994-08-17
ATE138387T1 (de) 1996-06-15
EP0506971B1 (en) 1996-05-22
AU635669B2 (en) 1993-03-25
WO1992006997A1 (fr) 1992-04-30
KR960004772B1 (ko) 1996-04-13
US5374713A (en) 1994-12-20
EP0506971A1 (en) 1992-10-07
DE69119747T2 (de) 1996-12-05
AU8716491A (en) 1992-05-20
CA2071910A1 (en) 1992-04-19

Similar Documents

Publication Publication Date Title
MX9304970A (es) ACIDOS ß-AMINOALQUIL- Y ß-N-PEPTIDILAMINOALQUIL-BORONICOS.
ATE440863T1 (de) Chemokine peptide, varianten, derivate und analoge. ihre verwendung in methode für die hemmung oder erhíhung von einer entzündungsreaktion
ATE202554T1 (de) Peptide-analoge mit irreversibler interleukin-1 beta-protease inhibitoren
MX9101346A (es) Proteasa de interleucina 1b e inhibidores de la proteasa de interleucina 1b.
FI964317A (fi) Tekijän-Xa-inhibiittoreita
NO960939D0 (no) Kininogenaseinhibitor
DK0587799T3 (da) Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning
DK0498784T3 (da) Hæmmere af retroviral protease
NO971621L (no) Keratinocyttvekstfaktoranaloger
DK0437556T3 (da) Substitutionsanaloger af magaininpeptider
KR920703634A (ko) 염증 부위로 부터 정제된 포스포리파제 a₂의 펩타이드 저해제
IT8921613A0 (it) Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.
EP0237202A3 (en) Novel renin inhibiting peptides having a dihydroxyethylene isostere transition state insert
DE60044945D1 (de) Auf scf peptid basiertes basolaterales sortiersignal und inhibitoren dafür
BR9711540A (pt) Inibidores de protease proteìnico estabilizados e variantes dos mesmos
DE69429642D1 (de) Lactol-Derivate, als Cathepsin L Inhibitoren
AU1521500A (en) Inhibition of angiogenesis by peptide analogs of high molecular weight kininogendomain
DE3782880D1 (de) Hemmende peptide.
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
CA2568107A1 (en) Anti-inflammatory peptides
DE69922150D1 (de) Deoxyhypusin reagenz und peptide
DE60038741D1 (de) Tachykininpeptide, ihre präpeptide und sie kodierende gene
ES2052447B1 (es) Peptidos hemorreguladores.
MX9605037A (es) Inhibidores de factor xa.
NO962204D0 (no) Dobbeltkjedede hemoregulatoriske peptider

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19920618

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19920810

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19920618

Comment text: Patent Application

PG1501 Laying open of application
G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19960320

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19960625

NORF Unpaid initial registration fee
PC1904 Unpaid initial registration fee