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KR920009981A - 아데노-관련된 바이러스 타입 2에 의해 암호화되는 rep 유전자의 항바이러스 활성 - Google Patents

아데노-관련된 바이러스 타입 2에 의해 암호화되는 rep 유전자의 항바이러스 활성 Download PDF

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Publication number
KR920009981A
KR920009981A KR1019910020336A KR910020336A KR920009981A KR 920009981 A KR920009981 A KR 920009981A KR 1019910020336 A KR1019910020336 A KR 1019910020336A KR 910020336 A KR910020336 A KR 910020336A KR 920009981 A KR920009981 A KR 920009981A
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KR
South Korea
Prior art keywords
rep gene
adeno
associated virus
virus type
antiviral activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019910020336A
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English (en)
Inventor
리트너 카롤라
쉬자키엘 제오르크
Original Assignee
스타인, 부크
베링베르케 아크티엔게젤샤프트
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Application filed by 스타인, 부크, 베링베르케 아크티엔게젤샤프트 filed Critical 스타인, 부크
Publication of KR920009981A publication Critical patent/KR920009981A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

아데노-관련된 바이러스 타입 2에 의해 암호화되는 rep 유전자의 항바이러스 활성
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 HIV-1 복제의 억제를 나타낸다.
제2도는 CAT 발현의 억제를 나타낸다.
제3도는 HIV-1과 AAV-2서열을 비교한 것이다.

Claims (5)

  1. 바이러스 감염 조절용 특정한 항바이러스제를 제조하기 위한 아데노-관련된 바이러스 타입 2(AAV-2)로부터 유도되는 rep 유전자 또는 이 유전자의 부분-서열의 용도.
  2. 제1항에 있어서, 조절되는 바이러스가 HIV-1 바이러스인 용도.
  3. AAV rep 유전자의 개방 판독 프레임의 해독 생성물인 펩타이드.
  4. 제3항에 있어서, 플스미드 pTAV2 또는 pTAV2-6의 삽입물의 해독 생성물인 펩타이드.
  5. 제3항 및 4항의 펩타이드중 하나 이상의 펩타이드를 포함하는 진단 키트.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910020336A 1990-11-17 1991-11-15 아데노-관련된 바이러스 타입 2에 의해 암호화되는 rep 유전자의 항바이러스 활성 Withdrawn KR920009981A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4036784.3 1990-11-17
DE4036784A DE4036784A1 (de) 1990-11-17 1990-11-17 Antivirale aktivitaet des vom adeno-assoziierten virus typ 2 codierten rep-gens

Publications (1)

Publication Number Publication Date
KR920009981A true KR920009981A (ko) 1992-06-26

Family

ID=6418520

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910020336A Withdrawn KR920009981A (ko) 1990-11-17 1991-11-15 아데노-관련된 바이러스 타입 2에 의해 암호화되는 rep 유전자의 항바이러스 활성

Country Status (7)

Country Link
EP (1) EP0486917A3 (ko)
KR (1) KR920009981A (ko)
AU (1) AU8785491A (ko)
CA (1) CA2055635A1 (ko)
DE (1) DE4036784A1 (ko)
IE (1) IE913993A1 (ko)
PT (1) PT99520A (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0733122A4 (en) * 1993-05-26 1998-06-10 Us Health FUSION PROTEINS CONTAINING REP VIRUS PROTEIN ASSOCIATED WITH ADENOVIRUS AND BACTERIAL PROTEIN
US6146847A (en) * 1996-11-01 2000-11-14 Genespan Corporation Stabilized transient gene expression
AU732445B2 (en) * 1996-11-01 2001-04-26 Genespan Corporation Stabilized transient gene expression

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291893A1 (en) * 1987-05-19 1988-11-23 The Du Pont Merck Pharmaceutical Company Stable human cell lines expressing an indicator gene product under virus-specific genetic controls
EP0327960A1 (en) * 1988-02-11 1989-08-16 F. Hoffmann-La Roche Ag Secretable forms of alkaline phosphatase
WO1992010574A1 (en) * 1990-12-06 1992-06-25 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Inhibition of human immunodeficiency virus by an adeno-associated virus gene for human cells

Also Published As

Publication number Publication date
DE4036784A1 (de) 1992-05-21
AU8785491A (en) 1993-01-28
PT99520A (pt) 1992-10-30
IE913993A1 (en) 1992-05-20
CA2055635A1 (en) 1992-05-18
EP0486917A3 (en) 1992-12-16
EP0486917A2 (de) 1992-05-27

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19911115

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid