EP0733122A4 - FUSION PROTEINS CONTAINING THE REP PROTEIN OF THE ADENO-ASSOCIATED VIRUS AND PROTEINS FROM BACTERIA - Google Patents

FUSION PROTEINS CONTAINING THE REP PROTEIN OF THE ADENO-ASSOCIATED VIRUS AND PROTEINS FROM BACTERIA

Info

Publication number: EP0733122A4
Authority: EP; European Patent Office
Prior art keywords: adeno; bacteria; proteins; associated virus; rep protein
Prior art date: 1993-05-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP94919252A

Other languages

German (de)

French (fr)

Other versions

EP0733122A1 (en

Inventor

Robert Kotin

Brian Safer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Genetic Therapy Inc

US Department of Health and Human Services

Original Assignee

Genetic Therapy Inc

US Department of Health and Human Services

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-26

Filing date

1994-05-26

Publication date

1998-06-10

1994-05-26 Application filed by Genetic Therapy Inc, US Department of Health and Human Services filed Critical Genetic Therapy Inc

1996-09-25 Publication of EP0733122A1 publication Critical patent/EP0733122A1/en

1998-06-10 Publication of EP0733122A4 publication Critical patent/EP0733122A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Virology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

EP94919252A 1993-05-26 1994-05-26 FUSION PROTEINS CONTAINING THE REP PROTEIN OF THE ADENO-ASSOCIATED VIRUS AND PROTEINS FROM BACTERIA Withdrawn EP0733122A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6723693A	1993-05-26	1993-05-26
US67236		1993-05-26
PCT/US1994/005940 WO1994028157A1 (en)	1993-05-26	1994-05-26	Fusion proteins containing adeno-associated virus rep protein and bacterial protein

Publications (2)

Publication Number	Publication Date
EP0733122A1 EP0733122A1 (en)	1996-09-25
EP0733122A4 true EP0733122A4 (en)	1998-06-10

Family

ID=22074622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP94919252A Withdrawn EP0733122A4 (en)	1993-05-26	1994-05-26	FUSION PROTEINS CONTAINING THE REP PROTEIN OF THE ADENO-ASSOCIATED VIRUS AND PROTEINS FROM BACTERIA

Country Status (4)

Country	Link
EP (1)	EP0733122A4 (en)
JP (1)	JPH09501309A (en)
CA (1)	CA2162271A1 (en)
WO (1)	WO1994028157A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6342390B1 (en)	1994-11-23	2002-01-29	The United States Of America As Represented By The Secretary Of Health And Human Services	Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
US5843742A (en) *	1994-12-16	1998-12-01	Avigen Incorporated	Adeno-associated derived vector systems for gene delivery and integration into target cells
US5756283A (en) *	1995-06-05	1998-05-26	The Trustees Of The University Of Pennsylvania	Method for improved production of recombinant adeno-associated viruses for gene therapy
US6281010B1 (en)	1995-06-05	2001-08-28	The Trustees Of The University Of Pennsylvania	Adenovirus gene therapy vehicle and cell line
DE19545126A1 (en) *	1995-12-04	1997-06-05	Hoechst Ag	ATP and nucleic acid binding protein with helicase properties
JP2001500376A (en) *	1996-09-06	2001-01-16	カイロンコーポレイション	Methods and compositions for liver-specific delivery of therapeutic molecules using recombinant AAV vectors
US6544523B1 (en)	1996-11-13	2003-04-08	Chiron Corporation	Mutant forms of Fas ligand and uses thereof
DE69841807D1 (en)	1997-11-06	2010-09-16	Novartis Vaccines & Diagnostic	NEISSERIAL ANTIGENE
AU1979599A (en)	1998-01-14	1999-08-02	Chiron S.P.A.	(neisseria meningitidis) antigens
CA2650642A1 (en)	1998-05-01	1999-11-11	Chiron Corporation	Neisseria meningitidis antigens and compositions
AU4309600A (en)	1999-04-30	2000-11-17	Chiron S.R.L.	Conserved neisserial antigens
GB9911683D0 (en)	1999-05-19	1999-07-21	Chiron Spa	Antigenic peptides
GB9916529D0 (en)	1999-07-14	1999-09-15	Chiron Spa	Antigenic peptides
CA2389321A1 (en)	1999-10-29	2001-05-03	Chiron S.P.A.	Neisserial antigenic peptides
BR0107679A (en)	2000-01-17	2004-07-06	Chiron Spa	Outer membrane vesicle (omv) vaccine comprising neisseria meningitidis serum group b outer membrane proteins
MX357775B (en)	2000-10-27	2018-07-20	J Craig Venter Inst Inc	Nucleic acids and proteins from streptococcus groups a b.
GB0107658D0 (en)	2001-03-27	2001-05-16	Chiron Spa	Streptococcus pneumoniae
GB0107661D0 (en)	2001-03-27	2001-05-16	Chiron Spa	Staphylococcus aureus
JP4413617B2 (en)	2001-12-12	2010-02-10	カイロンソチエタアレスポンサビリタリミタータ	Immunization against CHLAMYDIATRACHOMATIS
GB0308198D0 (en)	2003-04-09	2003-05-14	Chiron Srl	ADP-ribosylating bacterial toxin
EP1736541B1 (en)	2004-03-29	2013-01-23	Galpharma Co., Ltd.	Novel modified galectin 9 protein and use thereof
ATE522541T1 (en)	2006-06-09	2011-09-15	Novartis Ag	BACTERIAL ADHESIN CONFORMERS
WO2019032898A1 (en)	2017-08-09	2019-02-14	Bioverativ Therapeutics Inc.	Nucleic acid molecules and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0486917A2 (en) *	1990-11-17	1992-05-27	BEHRINGWERKE Aktiengesellschaft	Antiviral activity from the rep gene of adenoassociated virus-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5139941A (en) *	1985-10-31	1992-08-18	University Of Florida Research Foundation, Inc.	AAV transduction vectors

1994
- 1994-05-26 EP EP94919252A patent/EP0733122A4/en not_active Withdrawn
- 1994-05-26 WO PCT/US1994/005940 patent/WO1994028157A1/en not_active Application Discontinuation
- 1994-05-26 JP JP7500965A patent/JPH09501309A/en active Pending
- 1994-05-26 CA CA002162271A patent/CA2162271A1/en not_active Abandoned

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0486917A2 (en) *	1990-11-17	1992-05-27	BEHRINGWERKE Aktiengesellschaft	Antiviral activity from the rep gene of adenoassociated virus-2

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHIORINI J A ET AL: "BIOLOGICALLY ACTIVE REP PROTEINS OF ADENO-ASSOCIATED VIRUS TYPE 2 PRODUCED AS FUSION PROTEINS IN ESCHERICHIA COLI", JOURNAL OF VIROLOGY, vol. 68, no. 2, February 1994 (1994-02-01), pages 797 - 804, XP000608411 *
IM D.S: & MUZYCZKA N.: "The AAV origin bvinding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity.", CELL, vol. 61, 4 May 1990 (1990-05-04), pages 447 - 457, XP002060793 *
NEW ENGLAND BIOLABS CATALOG, 1992, pages 96 - 97, XP002061117 *
See also references of WO9428157A1 *

Also Published As

Publication number	Publication date
EP0733122A1 (en)	1996-09-25
WO1994028157A1 (en)	1994-12-08
JPH09501309A (en)	1997-02-10
CA2162271A1 (en)	1994-12-08

Publication	Publication Date	Title
EP0733122A4 (en)	1998-06-10	FUSION PROTEINS CONTAINING THE REP PROTEIN OF THE ADENO-ASSOCIATED VIRUS AND PROTEINS FROM BACTERIA
DE3787002D1 (en)	1993-09-16	SYNTHETIC PEPTIDES THAT GENERATE CELLULAR IMMUNITY AGAINST THE AIDS VIRUS AND ITS PROTEINS.
DE69723254D1 (en)	2003-08-07	PROTEIN OF THE OUTER MEMBRANE OF MORAXELLA CATARRHALIS OMP-106, ITS GENE SEQUENCE AND THEIR USE
EP0571442A4 (en)	1995-05-03	CYTOKIN INDUCIBLE PROTEIN TSG-14, ITS ENCODING DNA AND THEIR USE.
DE69628791D1 (en)	2003-07-31	Absorbent composition, absorbent material, and an absorbent product containing the absorbent material.
FI964311L (en)	1996-10-25	Bifunctional protein, preparation and use
DE69631065D1 (en)	2004-01-22	IMPROVED AGENT FOR REDUCING THE FLOW RESISTANCE OF SLUDGE
MY102472A (en)	1992-06-30	Preparation of funtional human urokinase proteins.
DE3861132D1 (en)	1991-01-10	DISMULING AND CLEANING AGENT, SUITABLE FOR SEPARATING PETROLEUM-WATER MIXTURES, EMISSIONS, IF ANY, AND APPLICATIONS THEREOF.
FI892408L (en)	1989-11-21	FIBRONECTIN-BINDING PROTEIN.
DE69531958D1 (en)	2003-11-20	(1-3) -BETA-D-GLUUCON-BINDING PROTEIN, ANTIBODY DETECTING THIS PROTEIN AND USE OF THE PROTEIN AND ANTIBODY
ATE47853T1 (en)	1989-11-15	5,6-DIFLUORAPHTYRIDINE AND 5,6,8TRIFLUOROQUINOLINE USABLE AS ANTIBACTERIAL AGENTS.
FI972384L (en)	1997-06-05	Novel dipeptide p-amidinobenzylamides containing N-terminal sulfonyl or amidinosulfonyl groups
DE3788807D1 (en)	1994-02-24	FUSION PROTEINS AND PARTICLES.
DE69727240D1 (en)	2004-02-19	COMBINATIONS CONTAINING VX478, ZIDOVUDIN AND 3TC FOR THE TREATMENT OF HIV
DE69714451D1 (en)	2002-09-05	PRION-BINDING PROTEINS AND THEIR USE
DE3850433D1 (en)	1994-08-04	Allergy treatment and composition therefor.
DE3852625D1 (en)	1995-02-09	Vectors and compounds for the expression of zymogen forms of human protein C.
BR9605046B1 (en)	2010-08-10	n- (pyrimidinyl) -benzenesulfonamide compounds and pharmaceutical preparation containing them.
FI921582L (en)	1992-04-09	FIBRONECTIN-BINDING PROTEIN.
DE69722433D1 (en)	2003-07-03	PHARMACEUTICAL PREPARATIONS CONTAINING ZIDOVUDIN AND LAMIVUDINE
AU3698595A (en)	1996-04-09	Dna sequence and protein of the non-structural reading frame i of the human parvovirus b19
DE69311146D1 (en)	1997-07-10	Cleaning sensor surfaces - method, sensor and cleaning element
DE69529295D1 (en)	2003-02-06	CHEMICAL PROTEIN DETURING TREATMENT
DE69327167D1 (en)	2000-01-05	NUCLEOTID SEQUENCES CODING FOR PROTEINS OF CRYPTOSPORIDIUM, POLYPEPTIDES CODED BY THESE SEQUENCES, AND KITS FOR THE USE THEREOF

Legal Events

Date	Code	Title	Description
1996-08-09	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1996-09-25	17P	Request for examination filed	Effective date: 19951202
1996-09-25	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1998-05-27	RHK1	Main classification (correction)	Ipc: C12N 15/62
1998-06-10	A4	Supplementary search report drawn up and despatched	Effective date: 19980428
1998-06-10	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1999-02-12	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1999-03-31	18D	Application deemed to be withdrawn	Effective date: 19980723