KR920004375A - 퀴놀론 유도체의 제조방법 - Google Patents
퀴놀론 유도체의 제조방법 Download PDFInfo
- Publication number
- KR920004375A KR920004375A KR1019900011962A KR900011962A KR920004375A KR 920004375 A KR920004375 A KR 920004375A KR 1019900011962 A KR1019900011962 A KR 1019900011962A KR 900011962 A KR900011962 A KR 900011962A KR 920004375 A KR920004375 A KR 920004375A
- Authority
- KR
- South Korea
- Prior art keywords
- copper
- compound
- formula
- quinolone derivative
- butanedione
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 3
- 150000007660 quinolones Chemical class 0.000 title claims 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 3
- 239000005749 Copper compound Substances 0.000 claims 3
- 229910052802 copper Inorganic materials 0.000 claims 3
- 239000010949 copper Substances 0.000 claims 3
- 150000001880 copper compounds Chemical class 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- WHZMLJFJMRIQBA-UHFFFAOYSA-N 1-(2,4-dichloro-5-fluorophenyl)butane-1,3-dione Chemical compound CC(=O)CC(=O)C1=CC(F)=C(Cl)C=C1Cl WHZMLJFJMRIQBA-UHFFFAOYSA-N 0.000 claims 1
- -1 2,4-Dichloro-5-fluorobenzoyl Chemical group 0.000 claims 1
- XXLBDECSHXPVTP-UHFFFAOYSA-N C1=CC2=C(C=C1F)C(=O)C=CN2Cl Chemical compound C1=CC2=C(C=C1F)C(=O)C=CN2Cl XXLBDECSHXPVTP-UHFFFAOYSA-N 0.000 claims 1
- 239000012670 alkaline solution Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- LNOQURRKNJKKBU-UHFFFAOYSA-N ethyl piperazine-1-carboxylate Chemical compound CCOC(=O)N1CCNCC1 LNOQURRKNJKKBU-UHFFFAOYSA-N 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (2)
- 다음 구조식(Ⅰ)로 표시되는 1-사이클로프로필-6-플루오로-1,4-디하이드로-4-옥소-7-피페라지닐-퀴놀린-3-카로복실산을 제조합에 있어서, 다음 구조식(Ⅲ)으로 표시되는 1-(2,4-디클로로-5-플루오로페닐)-1,3-부탄디온을 출발물질로하여 다음 구조식((Ⅴ)로 표시되는 4-사이클로프로필아민-3-(2,4-디클로로-5-플루오로벤조일)-4-에톡시-3-부탄디온을 제조하고, 이를 염기존재하에 반응시켜서 다음 구조식(Ⅵ)의 3-아세틸-1-싸이클로프로필-7-클로로-6-플루오로-1,4-디하이드로-4-옥소퀴놀린을 제조한 다음, 여기에다 구리 또는 구리화합물을 촉매로 하여 불화성 유기용매하에서 한쪽이 보호된 N-에톡시 카보 닐피페라진과 반응시키고 산화반응시킨 후 다음 구조식(Ⅷ)의 화합물을 제조하고 이를 알칼리용액중에서 가수 분해시켜서 됨을 특징으로 하는 퀴놀론유도체의 제조방법.
- 제1항에 있어서, 상기 촉매인 구리 또는 구리화합물을 구리 또는 구리화합물중에서 선택된 것 중 상기 구조식(Ⅵ)의 화합물에 대해 1,-20몰%중량으로 첨가 사용하는 것을 특징으로 하는 퀴놀론유도체의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019900011962A KR930000439B1 (ko) | 1990-08-03 | 1990-08-03 | 퀴놀론 유도체의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019900011962A KR930000439B1 (ko) | 1990-08-03 | 1990-08-03 | 퀴놀론 유도체의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR920004375A true KR920004375A (ko) | 1992-03-27 |
| KR930000439B1 KR930000439B1 (ko) | 1993-01-21 |
Family
ID=19302010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900011962A KR930000439B1 (ko) | 1990-08-03 | 1990-08-03 | 퀴놀론 유도체의 제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR930000439B1 (ko) |
-
1990
- 1990-08-03 KR KR1019900011962A patent/KR930000439B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR930000439B1 (ko) | 1993-01-21 |
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