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KR910016734A - 광학활성 알킬렌디옥시벤젠 유도체 및 치료에의 용도 - Google Patents

광학활성 알킬렌디옥시벤젠 유도체 및 치료에의 용도 Download PDF

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Publication number
KR910016734A
KR910016734A KR1019910003908A KR910003908A KR910016734A KR 910016734 A KR910016734 A KR 910016734A KR 1019910003908 A KR1019910003908 A KR 1019910003908A KR 910003908 A KR910003908 A KR 910003908A KR 910016734 A KR910016734 A KR 910016734A
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South Korea
Prior art keywords
compound
formula
integer
represented
structural formula
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KR1019910003908A
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KR100240242B1 (ko
Inventor
헤이다로오 이와다
아께미찌 바바
도시오 마쓰다
미쓰오 에가와
아끼히로 도베
겡이찌 사이도오
Original Assignee
에도오 다께도시
미쓰비시 가세이 가부시기가이샤
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Publication of KR910016734A publication Critical patent/KR910016734A/ko
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Publication of KR100240242B1 publication Critical patent/KR100240242B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

광학활성 알킬렌디옥시벤젠 유도체 및 치료에의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 하기 구조식(Ⅰ)의 광학활성 알킬렌디옥시벤젠 유도체 및 그 산부가염.
    위의 식에서, m은 2~5의 정수이고, n은 1~3의 정수이다.
  2. 제1항에 있어서, 하기 구조식(I')으로 나타내어지는 화합물.
    위의 식에서 m과 n은 앞서 정의된 바와 같다.
  3. 제2항에 있어서, m이 3,4 또는 5의 정수인 화합물.
  4. 제3항에 있어서, n이 1인 화합물.
  5. 제4항에 있어서, 5-[3-{(2S)-(1,4-벤조디옥산-2-일메틸)아미노}프로폭시]-1,3-벤조디옥솔 염산염.
  6. 제4항에 있어서, 5-[4-{(2S)-(1,4-벤조디옥산-2-일메틸)아미노}부록시]-1,3-벤조디옥솔 염산염.
  7. 제4항에 있어서,5-[5-{(2S)-(1,4-벤조디옥산-2-일메틸)아미노}펜틸옥시] -1 ,3-벤조디옥솔 염산염.
  8. 적당한 부형제 또는 담체와 더불어 하기 일반 구조식(Ⅱ)의 화합물 또는 그 산부가염 유효량을 필수 성분으로 하여 함유하는 불안증 치료용 약제학적 조성물.
    위의 식에서 m과 n은 앞서 정의된 바와 같다.
  9. 제8항에 있어서, 화합물이 하기 구조식(Ⅱ')으로 나타내어 지는 것인 조성물.
    위의 식에서 m과 n은 앞서 정의된 바와 같다.
  10. 제9항에 있어서, 화합물이 구조식(Ⅱ')로 나타내어지는 것이고, m이 3,4 또는 5의 정수인 조성물.
  11. 제10항에 있어서, 화합물이 구조식(Ⅱ')로 나타내어지는 것이고, S배위를 하고 있는 것인 조성물.
  12. 제7항 또는 제 8항에서 정의된 화합물 또는 이들의 약제학적으로 허용 되는 염 유효량을 온혈동물에게 투여하는 온형동물의 불안증 치료방법.
  13. 제7항 또는 제 8항에서 정의된 화합물 또는 이들의 약제학적으로 허용 되는 염의 항불안 의약으로 유용한 약제학적 조성물 제조를 위한 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910003908A 1990-03-14 1991-03-12 광학활성 알킬렌디옥시벤젠 유도체 및 치료에의 용도 KR100240242B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2-63839 1990-03-14
JP2063839A JPH03264528A (ja) 1990-03-14 1990-03-14 抗不安薬

Publications (2)

Publication Number Publication Date
KR910016734A true KR910016734A (ko) 1991-11-05
KR100240242B1 KR100240242B1 (ko) 2001-02-01

Family

ID=13240916

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KR1019910003908A KR100240242B1 (ko) 1990-03-14 1991-03-12 광학활성 알킬렌디옥시벤젠 유도체 및 치료에의 용도

Country Status (10)

Country Link
US (1) US5168099A (ko)
EP (1) EP0446921B1 (ko)
JP (1) JPH03264528A (ko)
KR (1) KR100240242B1 (ko)
AT (1) ATE171704T1 (ko)
CA (1) CA2038025C (ko)
DE (1) DE69130266T2 (ko)
DK (1) DK0446921T3 (ko)
ES (1) ES2122962T3 (ko)
TW (1) TW200398B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391570A (en) * 1993-10-14 1995-02-21 Bristol-Myers Squibb Aminomethyl-benzodioxane and benzopyran serotonergic agents
FR2716680B1 (fr) * 1994-02-25 1996-04-05 Adir Nouveaux dérivés de benzodioxane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5525347A (en) * 1995-01-31 1996-06-11 Medical University Of South Carolina Composition and methods for treating performance anxiety
US5998467A (en) * 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
ES2182175T3 (es) * 1997-05-20 2003-03-01 Mitsubishi Chem Corp Utilizacion de un derivado del alquilenodioxibenceno para el tratamiento de los trastornos del ritmo circadiano del sueño.
JP4316793B2 (ja) * 1997-08-19 2009-08-19 三菱化学株式会社 過敏性腸症候群の治療剤
WO2004096208A1 (en) * 2003-04-25 2004-11-11 Mitsubishi Pharma Corporation Composition for oral administration containing alkylene dioxybenzene derivative
CN101619059B (zh) * 2008-07-01 2011-09-14 江苏恩华药业股份有限公司 盐酸奥沙莫唑坦的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281245A (ko) * 1962-07-20
BE759468A (fr) * 1969-11-27 1971-05-26 Merck Patent Gmbh Derives de benzodioxanne
US4684739A (en) * 1980-12-15 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene derivatives and acid addition salts thereof

Also Published As

Publication number Publication date
DE69130266T2 (de) 1999-03-18
TW200398B (ko) 1993-02-21
EP0446921B1 (en) 1998-09-30
JPH03264528A (ja) 1991-11-25
DK0446921T3 (da) 1999-06-21
CA2038025A1 (en) 1991-09-15
ES2122962T3 (es) 1999-01-01
CA2038025C (en) 2005-12-20
EP0446921A2 (en) 1991-09-18
EP0446921A3 (en) 1992-01-29
US5168099A (en) 1992-12-01
ATE171704T1 (de) 1998-10-15
KR100240242B1 (ko) 2001-02-01
DE69130266D1 (de) 1998-11-05

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