[go: up one dir, main page]

KR910009686A - 키랄 3,4-에폭시 벤조피란의 신규 제조 방법 - Google Patents

키랄 3,4-에폭시 벤조피란의 신규 제조 방법 Download PDF

Info

Publication number
KR910009686A
KR910009686A KR1019900019429A KR900019429A KR910009686A KR 910009686 A KR910009686 A KR 910009686A KR 1019900019429 A KR1019900019429 A KR 1019900019429A KR 900019429 A KR900019429 A KR 900019429A KR 910009686 A KR910009686 A KR 910009686A
Authority
KR
South Korea
Prior art keywords
benzopyran
epoxy
dihydro
cyano
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019900019429A
Other languages
English (en)
Inventor
스미스 폴
그하브쇼우 마이클
Original Assignee
데이빗 로버츠
비이참 그루우프 피이엘시이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898926993A external-priority patent/GB8926993D0/en
Priority claimed from GB909023300A external-priority patent/GB9023300D0/en
Application filed by 데이빗 로버츠, 비이참 그루우프 피이엘시이 filed Critical 데이빗 로버츠
Publication of KR910009686A publication Critical patent/KR910009686A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

키랄 3,4-에폭시 벤조피란의 신규 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(D) 화합물:
    (상기식에서, NH2및 OH 부분은 트랜스이고, 각각(R,S) 또는 (S,R)이다.)의 사차 암모늄염의 염기 처리로 구성되는, 하기 일반식(A)′또는 (A)″화합물의 제조방법:
  2. 제1항에 있어서, Z이 산소인 방법.
  3. 제1항 또는 제2항에 있어서, R1이 치환체이고, R2가 수소인 방법.
  4. 제1항, 제2항 또는 제3항에 있어서, R3및 R4가 모두 메틸기인 방법.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, R1이 니트로, 시아노, 아세틸, CF3,C2F5,OCF3,에틸,이소프로필 또는 시클로펜틸인 방법.
  6. 제1항 내지 제5항중 어느 한 항에 있어서, 일반식(A′)의 화합물 즉, (S,S)-이성체의 제조방법.
  7. 제1항에 있어서, (3S,4S)-6-시아노-3,4-디히드로-3,4-에폭시-2,2-디메틸-2H-1-벤조피란, (3R,4R)-6-시아노-3,4-디히드로-3,4-에폭시-2,2-디메틸-2H-1-벤조피란, 또는 (3S, 4S)-6-에틸-3,4-디히드로-3,4-에폭시-2,2-디메틸-2H-1-벤조피란의 제조방법.
  8. 제1항에 있어서, 사차 암모늄 염이 RL(이때, R은 C1-4알킬이고, L은 수소이다)로 형성된 것인 방법.
  9. 제8항에 있어서, RL이 CH3I인 방법.
  10. 제1항에 따라 제조된 것과 같이, 각각 일반식(A′)또는(A″)의 (3S,4S) 또는 (3R,4R) 에폭시드로부터 제조되는 (3S,4R) 또는 (4R,4S) 칼륨 통로 활성제 벤조피란.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900019429A 1989-11-29 1990-11-28 키랄 3,4-에폭시 벤조피란의 신규 제조 방법 Ceased KR910009686A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB89269930 1989-11-29
GB898926993A GB8926993D0 (en) 1989-11-29 1989-11-29 Process
GB909023300A GB9023300D0 (en) 1990-10-25 1990-10-25 Process
GB90233008 1990-10-25

Publications (1)

Publication Number Publication Date
KR910009686A true KR910009686A (ko) 1991-06-28

Family

ID=26296278

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900019429A Ceased KR910009686A (ko) 1989-11-29 1990-11-28 키랄 3,4-에폭시 벤조피란의 신규 제조 방법

Country Status (8)

Country Link
EP (1) EP0430621A3 (ko)
JP (1) JPH03190878A (ko)
KR (1) KR910009686A (ko)
AU (1) AU633383B2 (ko)
CA (1) CA2030969A1 (ko)
IE (1) IE904278A1 (ko)
NZ (1) NZ236228A (ko)
PT (1) PT96023B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3936616A1 (de) * 1989-11-03 1991-05-08 Merck Patent Gmbh Verfahren zur enantiomerentrennung von benzopyranderivaten
US5573758A (en) * 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0076075B1 (en) * 1981-09-25 1986-11-20 Beecham Group Plc Pharmaceutically active benzopyran compounds
DE3811017A1 (de) * 1988-03-31 1989-10-19 Hoechst Ag Ungesaettigte n-benzopyranyllactame
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
DE3936616A1 (de) * 1989-11-03 1991-05-08 Merck Patent Gmbh Verfahren zur enantiomerentrennung von benzopyranderivaten

Also Published As

Publication number Publication date
PT96023A (pt) 1991-09-13
JPH03190878A (ja) 1991-08-20
EP0430621A2 (en) 1991-06-05
AU6697890A (en) 1991-06-06
NZ236228A (en) 1992-07-28
PT96023B (pt) 1997-08-29
CA2030969A1 (en) 1991-05-30
AU633383B2 (en) 1993-01-28
IE904278A1 (en) 1991-06-05
EP0430621A3 (en) 1992-03-04

Similar Documents

Publication Publication Date Title
AU4253193A (en) Urea-containing hydroxyethylamine compounds as retroviral protease inhibitors
BR9916711A (pt) Composto, composição de tensoativo, processo para preparar compostos, agente de modificação de viscosidade, e, auxiliar de flotação de minério
KR870000340A (ko) 광학 활성 피리도벤즈옥사진 유도체 및 이의 중간체의 제조방법
KR850000426A (ko) 디하이드로 벤조피란 유도체의 제조방법
KR860009023A (ko) 치환된 실릴기를 갖는 신규 에테르 화합물의 제조방법
KR910004592A (ko) 벤조피란 화합물, 그의 제조방법 및 약학 조성물
CY2405B1 (en) Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes.
KR970006265A (ko) 내장 광개시제(photoinitiator)를 함유하는 방사선-경화성 아크릴레이트
KR900016190A (ko) 2-페닐피리딘
KR870000318A (ko) 2,6-이치환된 4-에폭시프로필페닐 글리시딜 에테르의 제조방법
KR910009686A (ko) 키랄 3,4-에폭시 벤조피란의 신규 제조 방법
KR840003674A (ko) N,n'-비스(트리플로로메틸설포닐)옥사이드류 및 이를 함유하는 화학루미네센스 조성물
DE69815380D1 (de) N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind
KR890700584A (ko) 헤테로아릴카르복시아미드 유도체 그의 제조방법 및 그것을 함유하는 의약조성물
ES2008067A4 (es) Analogos de prostaciclina (pgi2).
KR870003074A (ko) 피라졸 유도체의 제조방법
KR900014415A (ko) 백금착물 및 활성 성분으로 이를 함유하는 항암제
KR850007588A (ko) β-나프틸알킬아민의 제조방법
RU94029675A (ru) Производные азоксицианобензола, их использование, способы их получения, фунгицидная композиция и способ борьбы с грибками
KR940000454A (ko) 신규 아졸 유도체, 그의 제조 방법 및 이 유도체를 함유하는 항진균제 및 항아로마타아제제
DE69014256D1 (de) Benzopyran-Derivate.
DE69200389D1 (de) Verfahren zur Herstellung von Enantiomeren von 3-Aminchromanderivaten.
ATE260267T1 (de) Verfahren zur herstellung von c-4-deacetyltaxanen
KR830005141A (ko) 방향족 아미노에탄올 화합물의 제조방법
KR870005988A (ko) 복소환식 화합물

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19901128

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19951128

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19901128

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19980421

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19980626

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19980421

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I