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KR900015735A - 프로판아민 유도체 - Google Patents

프로판아민 유도체 Download PDF

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KR900015735A
KR900015735A KR1019890005344A KR890005344A KR900015735A KR 900015735 A KR900015735 A KR 900015735A KR 1019890005344 A KR1019890005344 A KR 1019890005344A KR 890005344 A KR890005344 A KR 890005344A KR 900015735 A KR900015735 A KR 900015735A
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alkyl
hydrogen
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phenyl
compound
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뷰포드 캠벨 잭
플로이드 스미스 제랄드
윌슨 터너 2세 윌리엄
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메리 앤 터커
일라이 릴리 앤드 캄파니
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Abstract

내용 없음.

Description

프로판아민 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염.
    상기 식에서, R1은 나프틸, C1-C4알콕시에 의해 치환된 나프틸,
    [여기서, R6은 수소, C1-C4알킬, 트리할로메틸, 페틸 또는 -NR10R11(여기서, R10및 R11은 서로 독립적으로 수소 또는 C1-C4알킬이다)이고 R7은 수소, C1-C4알킬, C3-C6사이클로알킬-(CH2)m-, R12-X-R13, -(C1-C4알킬) C≡N,(여기서, m은 0 내지 3의 정수이고, n은 1 내지 4의 정수이며, X는 -O- 또는 -S-이고, R12및 R13은 각각 C1-C4알킬이며, Q는 페닐 또는 C1-C4알킬이고, Z는 NR10R11(여기서, R10및 R11은 상기에서 정의한 바와 같다)이거나, Z는 C3-C6사이클로 알킬, 나프틸, 피리디닐, 이미다졸릴, 트리아졸릴, 페닐 또는 할로, 트리할로멜틸 또는 C1-C4알콕시로부터 선택된 1 또는 2개의 그룹에 의해 치환된 페닐이다)이며, R8은 C3-C6사이클로 알킬 -(CH2)m-이고, R9는 C1-C4알킬이다]이고, R2는 수소, C1-C4알킬, 페닐, 할로겐에 의해 치환된 페닐, 비페닐, 나프틸, 피리디닐,
    (여기서, R14, R15및 R16은 서로 독립적으로 수소 또는 C1-C4알콕시이고, R17은 C5-C8알콕시이다)이며, R9은 수소, C1-C8알킬 또는 C3-C6알킬, 트리할로 메틸에 의해 치환된 사이클로 헥실 또는 -(CH2)nR10R11[여기서, n, R10및 R11은 상기에서 정의한 바와 같거나, 추가로 R10및 R11은 인접한 질소원자와 함께 모르폴리닐 그룹을 형성한다] 이거나, R4및 R5는 인접한 질소원자와 함께 피롤리디닐, 이미다졸릴 또는 1 또는 2개의 C1-C4알킬 그룹에 의해 임의로 치환된 모르폴리닐 그룹이다.
  2. 하기 일반식(II)의 화합물 또는 약제학적으로 허용되는 이의 염.
    상기식에서, R1은 나프틸, C1-C4알콕시에 의해 치환된 나프틸,
    (여기서, R4는 수소, C1-C4알킬, 트리할로 메틸 또는 페닐이고, R5는 C1-C14알킬이다)이고, R2는 페닐, 할로겐에 의해 치환된 페닐, 비페닐, 나프틸, 피리디닐
    R6, R7및 R8은 서로 독립적으로 수소 또는 C1-C4알콕시이고, R9는 C5-C8알콕시이다)이며, R3은 수소, C1-C4알킬 또는 -(CH2)mNR10R11(여기서, R10및 R11은 서로 독립적으로 수소 또는 C1-C4알킬이고, M은 1,2 또는 3이다)이다.
  3. 제1항에 있어서, R1이
    [여기서, R7은 C1-C14알킬 또는 -(CH2)nZ(여기서, n은 1 내지 4의 정수이고, Z는 페닐이다)이다]이고, R2는 수소, 페닐 또는 나프틸이며, R3, R4및 R5는 서로 독립적으로 수소 또는 C1-C4알킬인 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염.
  4. 제1항 또는 제3항에 있어서, R1에 대한 정의에서 R7이 C3-C10알킬이거나, R7이 -(CH2)nZ인 경우, n이 1 또는 2이고, R2는 수소 또는 페닐이며, R3, R4및 R5는 서로 독립적으로 수소 또는 C1-C4알킬인 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염.
  5. 제1항, 제3항 또는 제4항에 있어서, R1에 대한 정의에서 R7이 C4-C7알킬인 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염.
  6. 4-(헥실옥시)-β=페닐벤젠프로판아민 염산염.
  7. 활성 성분으로서 제1항 내지 제6항 중의 어느 한 항에서 청구한 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염을 하나 이상의 약제학적으로 허용되는 담체와 함께 포함함을 특징으로 하는 약제학적 조성물.
  8. a) 일반식(IV)의 니트릴을 일반식(V)의 R4, R5-치환된 아민의 존재하에 환원시켜 R3이 수소인 일반식(I)의 화합물 제조하거나, b) 일반식(VI)의 R1, R3-치화된 케톤을 일반식(V)의 R4, R5-치환된 아민과 반응시켜 R2가 수소인 일반식(I)의 화합물을 제조하거나, (c) 일반식(VIII)의 케톤을 일반식(V)의 R4, R5-치환된 아민의 존재하에 환원성 아민화 반응시키고, d) 생성된 일반식(I)의 화합물을 임의로 염형성시키는 공정을 포함함을 특징으로 하여 제1항 내지 제6항중 어느 한 항에서 청구한 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염을 제조하는 방법.
    상기 식에서, R1, R2, R3, R4및 R5는 제1항에서 정의한 바와 같다.
  9. 제8항에 따른 방법에 의해 생성된 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890005344A 1988-04-25 1989-04-24 프로판아민 유도체 KR900015735A (ko)

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US18567588A 1988-04-25 1988-04-25
US185,675 1988-04-25
US07/313,571 US5135955A (en) 1988-04-25 1989-02-22 Propanamine derivatives
US313.571 1989-02-22

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IT1240427B (it) * 1990-03-02 1993-12-15 Ministero Dall Uni E Della Ric Arilpropilammine ad azione antifungina
CA2115183A1 (en) * 1993-02-12 1994-08-13 Takashi Nomoto Substituted amic acid derivatives
EP0721783B1 (en) * 1994-06-07 2005-03-16 Toray Industries, Inc. Preventive and remedy for diseases caused by fibrinoid or thrombus formation in the lung
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
WO2009023964A1 (en) * 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
MX354184B (es) 2007-10-05 2018-02-16 Acucela Inc Compuestos alcoxi para el tratamiento de enfermedades.
US10471027B2 (en) * 2009-07-02 2019-11-12 Acucela, Inc. Pharmacology of visual cycle modulators
CN104703598A (zh) 2012-01-20 2015-06-10 奥克塞拉有限公司 用于疾病治疗的取代的杂环化合物
GB201322777D0 (en) * 2013-12-20 2014-02-05 Algipharma As Use of alginate oligomers as blood anticoagulants

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DE2656747C2 (de) * 1976-12-15 1984-07-05 Basf Ag, 6700 Ludwigshafen Morpholinderivate
CA1120058A (en) * 1978-07-03 1982-03-16 Jack Mills Phenethanolamines, formulations and potentiation of oncolytic drugs
NZ197798A (en) * 1978-07-03 1982-05-25 Lilly Co Eli 1-phenyl-3-aminobutane derivatives
CA1145766A (en) * 1978-07-03 1983-05-03 Jack Mills Optically active phenethanolamines and method for increasing cardiac contractility
DK160936C (da) * 1978-07-03 1991-10-21 Lilly Co Eli Analogifremgangsmaade til fremstilling af optisk aktive phenethanolaminer
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US4996235A (en) * 1987-11-25 1991-02-26 Eli Lilly And Company 3,4-diphenylbutanamines

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