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KR890700117A - 유효성분으로서 칼콘 유도체를 함유하는 항 궤양제 및 신규의 칼콘 유도체 - Google Patents

유효성분으로서 칼콘 유도체를 함유하는 항 궤양제 및 신규의 칼콘 유도체

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KR890700117A
KR890700117A KR1019880700971A KR880700971A KR890700117A KR 890700117 A KR890700117 A KR 890700117A KR 1019880700971 A KR1019880700971 A KR 1019880700971A KR 880700971 A KR880700971 A KR 880700971A KR 890700117 A KR890700117 A KR 890700117A
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propanone
carboxymethoxy
group
isopentylphenyl
methoxyphenyl
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고마자와 유끼오
다께다 시게후미
호사까 구니오
와따나베 도시히꼬
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쓰무라 아끼라
쓰무라 준펜도 인코포레이티드
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Priority claimed from JP29495286A external-priority patent/JPS63150241A/ja
Priority claimed from JP19819787A external-priority patent/JPS6442422A/ja
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Publication of KR890700117A publication Critical patent/KR890700117A/ko
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    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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Abstract

내용 없음

Description

유효성분으로서 칼콘 유도체를 함유하는 항 궤양제 및 신규의 칼콘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 유효성분으로서 다음의 일반식(Ⅰ)의 화합물을 함유하는 항궤양제
    상기 일반식중, X 및 Y는 각각 수소원자를 나타내거나 함께 단일결합을 형성하고, R'1은 히드록실기, 아세톡시기, 카르복시메톡시기 또는 메톡시카르보닐메톡시기를 나타내고, R'2는 수소원자, 이소프레닐기, 이소펜틸기 또는 프로필기를 나타내며, R'3은 히드록실기 또는 메톡시기를 나타내고, R'4는 수소원자, 히드록실기 또는 메톡시기를 나타내고, R'5는 수소원자, 히드록실기, 메톡시기 또는 이소펜틸기를 R'6은 히드록실기, 메톡시기 또는 카르복시메톡시기를 나타내며, R'7은 수소원자 또는 메톡시기를 나타낸다.
  2. 제1항에 있어서, 1-(2, 4, 6-트리히드록시-3-이소펜틸페닐-3-(4-히드록시-3-메톡시페닐)-1-프로판온, 1-(2, 4,6-트리히드록시-3-이소펜틸페닐)-3-(4-히드록시-3, 5-디메톡시페닐)-1-프로판온, 1-(2-카로복시메톡시-4-메톡시-3-이소펜틸페닐)-3-(4-메톡시페닐)-1-프로판온, 1-(2-히드록시-4-메톡시-3-이소펜틸페닐_-3(4-카르복시메톡시페닐)-1-프로판온, 1,(2-카르복시-메톡시-4,6-디메톡시-3-이소펜틸페닐)-3-(4-히드록시-3-메톡시페닐)-1-프로판온, 1-(2-카르복시메톡시-4,6-디메톡시-3-이소펜틸페닐)-3,(3-히드록시-4-메톡시페닐)-1-프로판온, 1-(2-카르복시메톡시-4,6-디메톡시-3-이소펜틸페닐) -3-(4-히드록시-3,5-디메톡시페닐)-1-프로판온, 2'-카르복시메톡시-4, 4 -디메톡시-3 -(3-메틸-2-부테닐)칼콘, 2 -카르복시메톡시-4, 4 , 6 -트리메톡시-3 -이소펜틸칼콘, 3-(4-히드록시페닐)-1-(2, 4, 6-트리히드록시-3-n-프로필페닐)-1-프로판온 1-(2-카르복시메톡시-4, 6-디메톡시페닐)-3-(4-메톡시페닐)-1-프로판온, 1-[2-카르복시메톡시-4, 6-디메톡시-3-(3-메틸-2-부테닐)페닐]-3-(4-메톡시페닐)-1-프로판온,2 -카르복시메톡시-4, 4 , 6 -트리메톡시칼콘, 2 -카르복시메톡시-4, 4 , 6 -트리메톡시-3 -(3-메틸-2-부테닐)칼콘, 2 , 4, 4 -트리히드록시칼콘, 2 -히드록시-4, 4 -디메톡시-3 -(3-메틸-2-부테닐)칼콘, 2 , 4, 4 , 6 -테트라히드록시-3 -(3-메틸-2-부테닐)칼콘, 2 -아세톡시-4, 4 , 6 -트리히드록시-3 -(3-메틸-2-부테닐)칼콘, 2 , 3, 4, 4 -테트라히드록시칼콘, 2 , 3, 4, 4 , 6 -펜타히드록시칼콘, 2 , 4, 4 , 6 -테트라히드록시-3 -이소펜틸칼콘, 1-(2, 4-디히드록시페닐)-3-(4-히드록시페닐)-1-프로판온, 1-(2, 4, 6-트리히드록시페닐)-3-(4-히드록시페닐)-1-프로판온,1-[2-아세톡시-4, 6-디히드록시-3-(3-메틸-2-부테닐)페닐]-3-(4-히드록시페닐)-1-프로판온, 1-[2, 4, 6-트리히드록시-3-(3-메틸-2-부테닐)페닐]-3-(4-히드록시페닐)-1-프로판온, 1-(2, 4, 6-트리히드록시-3-이소펜틸페닐)-3-(4-히드록시페닐)-1-프로판온, 1-(2, 4-디히드록시페닐)-3-(3, 4-디히드록시페닐)-1-프로판온, 1-(2, 4, 6-트리히드록시페닐)-3-(3, 4-디히드록시페닐)-1-프로판온, 1-(2-아세톡시-4, 6-디히드록시-3-이소펜틸페닐)-3-(4-히드록시페닐)-1-프로판온, 1-(2-히드록시-4, 6-디메톡시-3-이소펜탈페닐)-3-(4-메톡시페닐)-1-프로판온, 1-(4, 6-디히드록시-2-메톡시카르보닐메톡시-3-이소펜틸페닐)-3-(4-히드록시-페닐)-1-프로판온, 1-(2-카르복시메톡시-4, 6-디히드록시-3-이소펜틸페닐)-3-(4-히드록시페닐)-1-프로판온, 1-(2-히드록시-4-메톡시-3-이소펜틸페닐)-3-(4-메톡시페닐)-1-프로판온, 1-(3-이소펜틸-4, 6-디메톡시-2-메톡시카르보닐메톡시페닐)-3-(4-메톡시페닐)-1-프로판온, 1-(2-카르복시메톡시-4, 6-메톡시-3-이소펜틸페닐)-3-(4-메톡시페닐)-1-프로판온, 1-(2, 4-디히드록시-3-이소펜틸페닐)-3-(4-히드록시페닐)-1-프로판온, 및 1-(2, 4, 6-트리히드록시-3-이소펜틸페닐)-3-(4-히드록시-3-이소펜틸)-1-프로판온 중에서 화합물을 선택함을 특징으로 하는 항궤양제.
  3. 제2항에 있어서, 1-(2-카르복시메톡시-4-메톡시-3-이소펜틸페닐)-3-(4-메톡시페닐)-1-프로판온, 2 -카르복시메톡시-4-4 -디메톡시-3 -(3-메틸-2-부테닐)칼콘, 2 -카르복시메톡시-4, 4 , 6 -트리메톡시-3 -이소펜틸칼콘, 1-(2-카르복시메톡시-4, 6 -디메톡시페닐)-3-(4-메톡시페닐)-1-프로판온, 2 -카르복시메톡시-4, 4 , 6 -트리메톡시칼콘, 2 -카르복시메톡시-4, 4 , 6 -트리메톡시-3 -(3-메틸-2-부테닐)칼콘, 1-(2, 4-디히드록시페닐)-3-(3, 4-디히드록시페닐)-1-프로판온, 및 1-(2-카르복시메톡시-4, 6-디메톡시-3-이소펜틸페닐)-3-(4-메톡시페닐)-1-프로판온 중에서 화합물을 선택함을 특징으로 하는 항궤양제.
  4. 다음의 일반식(Ⅰ )으로 나타내는 화합물
    상기 일반식중, X' 및 Y' 는 각각 수소원자를 나타내거나 함께 결합을 형성하고, R'1은 히드록시기 또는 카르복시메톡시기를 나타내며 R'2는 수소원자, 이소프레닐기, 이소펜틸기 또는 프로필기를 나타내고, R'3은 히드록시기 또는 메톡시기를 나타내며, R'4는 수소원자, 히드록실기 또는 메톡시기를, R'5는 수소원자, 히드록실기, 메톡시기 또는 이소펜틸기, R'6은 히드록시기, 메톡시기 또는 카르복시메톡시기를 나타내고, R'7은 수소원자 또는 메톡시기를 나타내며, 만약 (1)R'2가 수소원자이며, R'4, R'4, R'5및 R'6중 적어도 하나는 메톡시기가 아니고, (2), R'2가 이소프레닐기이며, R' 1은 카르복시메톡시기이고, (3) R'2가 이소펜틸기이고 R'5와 R'7이 각각 수소원자이면, R' 는 수소원자이고, R'1및 R'6중 한가지는 카르복시메톡시기이며, (4) R'4가 수소원자가 아니면 R'3및 R'4는 일반적으로 히드록실기 또는 메톡시기를 나타내며, (5) R'5가 히드록실기이면, R'6은 메톡시기이고, (6) R' 가 에톡시기이면 R'6은 히드록실기이고, (7) R'6이 카르복시메톡시기이면 R'1은 히드록실기이다.
  5. 제4항에 있어서, 1-(2, 4, 6-트리-히드록시-3-이소펜틸페닐)-3-(4-히드록시-3-메톡시페닐)-1-프로판온, 1-(2, 4, 6-트리히드록시-3-이소펜틸-페닐)-3-(4-히드록시-3, 5-디메톡시페닐)-1-프로판온, 1-(2-카르복시메톡시-4-메톡시-3-이소펜틸페닐)-3-(4-메톡시페닐)-1-프로판온, 1-(2-히드록시-4-메톡시-3-이소펜틸페닐)-3-(4-카르복시메톡시페닐)-1-프로판온, 1-(2-카르복시메톡시-4, 6-디메톡시-3-이소펜틸페닐)-3-(4-히드록시-3-메톡시페닐)-1-프로판온, 1-(2-카르복시메톡시-4, 6-디메톡시-3-이소펜틸페닐)-3-(3-히드록시-4-메톡시페닐)-1-프로판온, 1-(2-카르복시메톡시-4, 6-디메톡시-3-이소펜틸페닐)-3-(4-히드록시-3, 5-디메톡시페닐)-1-프로판온, 2 -카르복시메톡시-4, 4 -디메톡시-3 -(3-메틸-2-부테닐)칼콘, 2 -카르복시메톡시-4, 4 , 6 -트리메톡시-3 -이소펜틸칼콘, 3-(4-히드록시-페닐)-1-(2, 4, 6-트리히드록시-3-n-프로필페닐)-1-프로판온, 1-(2-카르복시메톡시-4, 6-디메톡시페닐)-3-(4-메톡시페닐)-1-프로판온, 1-[2-카르복실메톡시-4, 6-디메톡시-3-(3-메틸-2-부테닐)페닐]-3-(4-메톡시페닐)-1-프로판온, 2 -카르복시메톡시-4, 4 , 6 -트리메톡시칼콘 및 2 -카르복시메톡시-4, 4 , 6 -트리메톡시-3 -(3-메틸-2-부테닐)칼콘 중에서 선택되는 화합물.
  6. 제5항에 있어서, 1-(2-카르복시메톡시-3-이소펜틸-4-메톡시페닐)-3-(4-메톡시페닐)-1-프로판온, 2 -카르복시메톡시-4, 4 -디메톡시-3 -(3-메틸-2-부테닐)칼콘, 2 -카르복시메톡시-4, 4 , 6 -트리메톡시-3-이소펜틸칼콘, 1-(2-카르복시메톡시-4, 6-디메톡시페닐)-3-(4-메톡시페닐)-1-프로판온, 2 -카르복시메톡시-4, 4 -트리메톡시칼콘 및 2 -카르복시메톡시-4, 4 , 6 -트리메톡시-3 -(3-메틸-2-부테닐)칼콘 중에서 선택되는 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880700971A 1986-12-12 1987-12-12 유효성분으로서 칼콘 유도체를 함유하는 항 궤양제 및 신규의 칼콘 유도체 Withdrawn KR890700117A (ko)

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JP61-294952 1986-12-12
JP29495286A JPS63150241A (ja) 1986-12-12 1986-12-12 カルコン誘導体および該カルコン誘導体を有効成分とする抗潰瘍剤
JP19819787A JPS6442422A (en) 1987-08-10 1987-08-10 Antiulcer agent
JP62-198197 1987-08-10
PCT/JP1987/000973 WO1988004288A1 (en) 1986-12-12 1987-12-12 Anti-ulcerous agent containing chalcone derivative as effective ingredient and novel chalcone derivatives

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