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KR890015730A - 항염증성인 피부 보습용 조성물 및 이것의 제조방법 - Google Patents

항염증성인 피부 보습용 조성물 및 이것의 제조방법 Download PDF

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KR890015730A
KR890015730A KR1019890004378A KR890004378A KR890015730A KR 890015730 A KR890015730 A KR 890015730A KR 1019890004378 A KR1019890004378 A KR 1019890004378A KR 890004378 A KR890004378 A KR 890004378A KR 890015730 A KR890015730 A KR 890015730A
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마노하 게리아 네이빈
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원본미기재
워너-람버트 컴퍼니
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/007Preparations for dry skin

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  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

항염증성인 피부 보습용 조성물 및 이것의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (40)

  1. (1) 약30%-약80%의 오일 및 HLB수가 약7-약12이고 약5%-약9% 존재하는 비이온성 계면활성제로 이루어진 오일 상 ; (2) 약0.05%-약5%의 수성 농후제 및 약15%-약65%의 물로 이루어진 수성 상 및 (3) 효과적인 양의 코르티코스테로이드가 아닌 약물로 구성되고 오일상이 수성상에 부가되어 유제를 형성하는 약물이 첨가된 피부 보호 조성물.
  2. 높은 온도를 유지하면서 계면활성제를 오일에 용해시키고 혼합물을 가열하여 오일상을 만들고, 물내에 수성 농후제를 분산시키고 혼합물을 가열하여 수성상을 만들고, 수성상에 가열한 오일상을 천천히 부가하고 전단력을 높게해 혼합하여 유제를 만들고 효과적인 양의 약물과 혼합시키는데, 여기에서 약물은 코르티코스테로이드가 아니고 일정한 느린 속도로 물 상에 오일상을 부가하여 물리적으로 안정한 유제를 만들며 피부 보호 조성물을 회수하는 단계로 이루어진 피부 보호 조성물을 제조하는 방법.
  3. 높은 온도를 유지하면서 계면활성제를 오일에 용해시키고 용액을 가열하여 오일상을 만들고, 중화제를 필요로 하는 수성 농후제를 물내에 분산시키고 이 분산액을 가열하여 수성상을 만들고, 수성상에 가열된 오일상을 천천히 부가하고 전단력이 높게해 혼합하여 유제를 만들고 효과적인 양의 약물과 혼합시키는데, 여기에서 약물은 코르티코스테로이드가 아니고 균일한 느린 속도로 물 상에 오일상을 부가하여 물리적으로 안정한 유제를 만들고 효과적인 양의 중화제를 부가하여 유제를 중화시키며 피부 보호 조성물을 회수하는 단계로 이루어진 피부 보호 조성물을 제조하는 방법.
  4. (1) 약30%-약80%의 오일 및 HLB수가 약7-약12이고 약5%-약9% 존재하는 비이온성 계면활성제로 이루어진 오일 상 ; (2) 약0.05%-약5%의 수성 농후제 및 효과적인 양의 중화제 및 약 15%-약65%의 물로 이루어진 수성 상 및 (3) 효과적인 양의 코르티코스테로이드가 아닌 약물로 구성되고 오일상이 수성상에 부가되어 유제를 형성하는 피부 보호 조성물.
  5. (1) 약30%-약80%의 오일 및 HLB수가 약7-약12이고 약5%-약9% 존재하는 비이온성 계면활성제로 이루어진 오일 상 ; (2) 약0.05%-약5%의 수성 농후제 및 효과적인 양의 중화제 및 약15%-약65%의 물로 이루어진 수성 상 및 (3) 효과적인 양의 코르티코스테로이드가 아닌 약물로 구성되고 오일상이 수성상에 부가되어 유제를 형성하고 그후 유제가 효과적인 양의 중화제로 중화되는 것으로 이루어진 효과적인 양의 피부 보호 조성물을 피부에 도포하는 것으로 구성된 피부를 치료하는 방법.
  6. (1) 약30%-약80%의 오일 및 HLB수가 약7-약12이고 약5%-약9% 존재하는 비이온성 계면활성제로 이루어진 오일 상 ; (2) 약0.05%-약5%의 수성 농후제 및 약15%-약65%의 물로 이루어진 수성 상 및 (3) 효과적인 양의 코르티코스테로이드가 아닌 약물로 구성되고 오일상이 수성상에 부가되어 유제를 형성하는 것으로 이루어진 효과적인 양의 피부 보호 조성물을 피부에 도포하는 것으로 구성된 피부를 처리하는 방법.
  7. 제 1 항 또는 제 4 항에 있어서, 오일이 동물성 오일, 식물성 오일, 미네랄 오일, 합성 오일 및 이들의 혼합물로 이루어진 조성물.
  8. 제 1 항 또는 제 4 항에 있어서, 오일이 라놀린, 지방산 에스테르, 어유, 고래기름, 어간유, 물범오일, 스콸란 및 이들의 혼합물로 이루어진 그룹으로 부터 선택되는 동물성 오일인 조성물.
  9. 제 1 항 또는 제 4 항에 있어서, 오일이 피자마유, 아마인유, 해바라기 오일, 콩기름, 올리브유, 낙화생유, 평지종자유, 옥수수 기름, 잇꽃 종자유, 면실유, 코코낫 오일, 팜유, 팜핵유, 감편도유, 야라보오일, 아바카도 오일, 세리알 젬 오일, 퍼셀린 오일 및 이들의 혼합물로 이루어진 그룹으로부터 선택되는 식물성 오일인 조성물.
  10. 제 1 항 또는 제 4 항에 있어서, 오일이 백색 광유, 파라핀 오일, 황색 와셀린 오일, 와셀린 및 이들의 혼합물로 구성된 그룹으로부터 선택되는 미네랄오일인 조성물.
  11. 제 1 항 또는 제 4 항에 있어서, 오일이 실리콘 오일, 디메틸폴리실옥산, 환식 실리콘, 메틸페닐폴리실옥산, 실리콘-글리콜 공중합체, 및 이들의 혼합물로 이루어진 그룹으로부터 선택되는 합성 오일인 조성물.
  12. 제 1 항 또는 제 4 항에 있어서, 비이온성 계면활성제가 알카놀아미드, 폴리옥시에틸렌, 폴리옥시에틸렌지방산 에스테르, 폴리에틸렌글리콜 유도체, 폴리에틸렌이유도체, 에톡실화되고 수소첨가된 피자마유로 이루어진 그룹의 하나인 조성물.
  13. 제 1 항 또는 제 4 항에 있어서, 비이온성 계면활성제가 폴리옥시에틸렌 (2) 스테아릴 에테르, POE(2) 올레일 에테르, PPG (5) 세테스 20, POE (5) 스테아레이트, POE (20) 스테아릴 에테르 및 이들의 혼합물로 이루어진 그룹의 하나인 조성물.
  14. 제 1 항 또는 제 4 항에 있어서, 수성 농후제가 천연 검, 합성 검, 겔화제 및 이들의 혼합물로 이루어진 그룹의 하나인 조성물.
  15. 제 1 항 또는 제 4 항에 있어서, 수성농후제가 알기네이트, 카라게난, 키산탄 검, 젤라틴, 구아, 아라비아 고무, 구주콩 나무, 트라가칸드, 로커스트 빈검, 카라야, 펙틴, 아가 및 이들의 혼합물로 이루어진 그룹으로 부터 선택된 천연 검인 조성물.
  16. 제 1 항 또는 제 4 항에 있어서, 수성 농후제가 셀룰로스 에테르 및 에스테르, 메틸셀룰로스, 소듐 카복시메틸셀룰로스, 카복시메틸셀룰로스, 하이드록시프로필셀룰로스, 카보더 및 카보폴 및 이들의 혼합물로 이루어진 그룹으로 부터 선택된 합성 검인 조성물.
  17. 제 1 항 또는 제 4 항에 있어서, 수성 농후제가 콜로이드성의 수화된 알루미늄 실리케이트, 벤토나이트, 합성 헥토라이트, 라포나이트, 콜로이드성 실리카 및 이들의 혼합물로 이루어진 그룹의 하나인 조성물.
  18. 제 4 항에 있어서, 중화제가 염기성 알칼리 금속염, 염기성 알칼리 토금속염, 염기성 아민 화합물 및 이들의 혼합물로 이루어진 그룹의 하나인 조성물.
  19. 제 4 항에 있어서, 중화제가 알칼리 금속 및 알칼리 토금속의 수산화물 및 탄산염, 트리에탄올 아민이소프로필아민 및 이들의 혼합물로 이루어진 그룹의 하나인 조성물.
  20. 제 3 항 또는 제 5 항에 있어서, 중화제가 염기성 알칼리 금속, 알칼리 토금속염, 염기성 아민 화합물 및 이들의 혼합물로 이루어진 그룹의 하나인 방법.
  21. 제 3 항 또는 제 5 항에 있어서, 중화제가 알칼리 금속 및 알칼리 토금속의 수산화물 및 탄산염, 트리에탄올아민, 이소프로필아민 및 이들의 혼합물로 이루어진 그룹의 하나인 방법.
  22. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 오일이 동물성 오일, 식물성 오일, 미네랄 오일, 합성 오일 및 이들의 혼합물로 이루어진 그룹의 하나인 방법.
  23. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 오일이 라놀린, 지방산 에스테르, 어유, 고래기름, 어간유, 물범오일, 스콸란 및 이들의 혼합물로 이루어진 그룹으로 부터 선택된 동물성 오일인 방법.
  24. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 오일이 피자마유, 아마인유, 해바라기 오일, 콩기름, 올리브유, 낙화생유, 평지종자유, 옥수수기름, 잇꽃 종자유, 면실유, 코코낫 오일, 팜유, 팜핵유, 감편도유, 야라보 오일, 아바카도 오일, 세리알 젬 오일, 퍼셀린 오일 및 이들의 혼합물로 이루어진 그룹으로 부터 선택된 식물성 오일인 방법.
  25. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 오일이 백색 광유, 파라핀 오일, 황색 와셀린 오일, 와셀린 및 이들의 혼합물로 이루어진 그룹으로부터 선택된 미네랄 오일인 방법.
  26. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 오일이 실리콘 오일, 디메틸폴리실옥산, 환식실리콘, 메틸페닐폴리실옥신, 실리콘-글리콜 공중합체 및 이들의 혼합물로 이루어진 그룹으로부터 선택된 합성오일인 방법.
  27. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 비이온성 계면활성제가 알카놀아미드, 폴리옥시에틸렌, 폴리옥시에틸렌 지방산 에스테르, 폴리에틸렌글리콜유도체, 폴리에틸렌아민 유도체, 에톡실화되고 수소가 첨가된 피자마유로 이루어진 그룹의 하나인 방법.
  28. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 비이온성 계면활성제가 폴리옥시에틸렌(2) 스테아릴 에테르, POE (2)올레일 에테르, PPG (5)세레스 20, POE(5) 스테아레이트, POE(20)스테아릴에테르 및 이들의 혼합물로 이루어진 그룹의 하나인 방법.
  29. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 수성 농후제가 천연검, 합성검, 젤화제, 이들의 혼합물로 이루어진 그룹으로부터 선택되는 방법.
  30. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 수성 농후제가 알기네이트, 카라게난, 키산탄검, 젤라틴, 구아, 아라비아 고무, 구주콩 나무, 트라가칸드, 로커스트 빈 검, 카라야, 펙틴, 아가 및 이들의 혼합물로 이루어진 그룹으로부터 선택된 천연검인 방법.
  31. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 수성 농후제가 셀룰로스 에테르 및 에스테르, 메틸 셀룰로스, 소듐 카복시메틸셀룰로스, 카복시메틸셀룰로스 하이드록시프로필셀룰로스, 카보더 및 카보폴 및 이들의 혼합물로 이루어진 그룹으로부터 선택된 합성 검인 방법.
  32. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 수성 농후제는 콜로이드성의 수소가 첨가된 알루미늄 실리케이트, 벤토나이트, 합성 헥토라이트, 라포나이트 콜로이드성 실리카 및 이들의 혼합물로 이루어진 그룹의 하나인 방법.
  33. 제 3 항에 있어서, 중화제가 염기성 알칼리금속 염, 알칼리 토금속 염, 염기성 아민 화합물 및 이들의 혼합물로 이루어진 그룹의 하나인 방법.
  34. 제 3 항에 있어서, 중화제가 알칼리 금속 및 알칼리 토금속의 수산화물 및 탄산염, 트리에탄올아민, 이소프로필아민 및 이들의 혼합물로 이루어진 그룹의 하나인 방법.
  35. 제 1 항 또는 제 4 항에 있어서, 오일이 미네랄 오일인 조성물.
  36. 제 2 항, 제 3 항, 제 5 항 또는 제 6 항에 있어서, 오일이 미네랄 오일인 방법.
  37. 제 1 항 또는 제 4 항에 있어서, 약물이 하이드로코르티손, 하이드로코르티손 아세테이트, 하이드로코르티손 발레레이트, 덱사메타손, 트리암시놀론, 트리암시놀론 아세토나이드, 프레드니손, 클로코톨론, 클로코톨론 피발레이트, 메틸프레드니솔론, 메틸프레드니솔론 아세테이트, 베타메타손, 베타메타손 벤조에이트, 베타메타손 디프로피오네이트, 메타메타손 발레레이트, 데소나이드, 디플로라손디아세테이트, 플루오시노나이드 할시노나이드 및 이들의 혼합물로 구성된 그룹으로부터 선택된 코르티코스테로이드인 조성물.
  38. 제 1 항 또는 제 4 항에 있어서, 약물이 하이드로코티손 아세테이트인 조성물.
  39. 제 1 항, 제 2 항, 제 3 항 또는 제 6 항에 있어서, 약물이 하이드로코르티손, 하이드로코르티손 아세테이트, 하이드로코르티손 발레레이트, 덱사메타손, 트리암시놀론, 트리암시놀론 아세토나이드, 프레드니손, 클로코톨론, 클로코톨론 피발레이트, 메틸프레드니솔론, 메틸프레드니솔론 아세테이트, 베타메타손, 베타메타손 벤조에이트, 베타메타손 디프로피오네이트, 메타메타손발레레이트, 데소나이드, 디플로라손 디아세테이트, 플루오시노나이드 할시노나이드 및 이들의 혼합물로 구성된 그룹으로부터 선택된 코르티코스테로이드인 방법.
  40. 제 2 항, 제 3 항, 제 4 항 또는 제 6 항에 있어서, 약물이 하이드로코티손 아세테이트인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890004378A 1988-04-04 1989-04-03 항염증성인 피부 보습용 조성물 및 이것의 제조방법 Withdrawn KR890015730A (ko)

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