KR880012645A - 항-진균활성도를 가지는 β-시클로 덱스트린 착염 - Google Patents
항-진균활성도를 가지는 β-시클로 덱스트린 착염 Download PDFInfo
- Publication number
- KR880012645A KR880012645A KR1019880004742A KR880004742A KR880012645A KR 880012645 A KR880012645 A KR 880012645A KR 1019880004742 A KR1019880004742 A KR 1019880004742A KR 880004742 A KR880004742 A KR 880004742A KR 880012645 A KR880012645 A KR 880012645A
- Authority
- KR
- South Korea
- Prior art keywords
- complex salt
- dichlorophenyl
- cyclodextrin
- cyclodextrin complex
- fungal activity
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 8
- 229920000858 Cyclodextrin Polymers 0.000 title claims description 5
- 239000001116 FEMA 4028 Substances 0.000 title claims description 5
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 title claims description 5
- 235000011175 beta-cyclodextrine Nutrition 0.000 title claims description 5
- 229960004853 betadex Drugs 0.000 title claims description 5
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- YYTZRDXGDDUJTF-UHFFFAOYSA-N COC1=NC=CN1CCC2=C(C=C(C=C2)Cl)Cl Chemical compound COC1=NC=CN1CCC2=C(C=C(C=C2)Cl)Cl YYTZRDXGDDUJTF-UHFFFAOYSA-N 0.000 claims 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000002076 thermal analysis method Methods 0.000 description 2
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 1
- 229960003913 econazole Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Communicable Diseases (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1도는 미코나졸과 β-시클로덱스트린과의 혼합물과 착염의 각각의 회절열분석도. 제 2도는 에코나졸과 β-시클로덱스트린과의 혼합물과 착염의 각각의 회절열분석도.
Claims (7)
1-(2-(2,4-디클로로페닐)-2-((2,4-디클로로페닐)-메톡시)에틸)-1H-이미다졸 및 1-(2-((4-클로로페닐)-메톡시-2-(2,4-디클로로페닐)-에틸-1H-이미다졸을 포함하는 그룹에서 선택된 화합물과 β-시클로덱스트린의 착염.
제 1항에 있어서, 항-진균약제로서 유용한 착염.
β-시클로로덱스트린의 당량을 각각 미코나졸과 에코나졸과 뜨거운 조건에서 물속에서 반응시키는 것을 특징으로 하는 제 1항에 따른 착염의 제조방법.
제 3항에 있어서, 반응을 40℃에서 교반하면서 실시하는 것을 특징으로 하는 방법.
제 3항에 있어서, 반응생성물을 동결건조하는 것을 특징으로 하는 방법.
활성성분으로서 제 1항에 따른 β-시클로덱스트린의 착염과 이와 유용한 부형제를 포함하는 것을 특징으로 하는 제약학적 조성물.
제 6항에 있어서, 국소적 사용에 적합한 형태로된 것을 특징으로 하는 제약학적 조성물.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20256/87A IT1203968B (it) | 1987-04-24 | 1987-04-24 | Complessi di b-ciclodestrina ad attivita' antimicotica |
| IT20256A/87 | 1987-04-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR880012645A true KR880012645A (ko) | 1988-11-28 |
| KR970004051B1 KR970004051B1 (ko) | 1997-03-24 |
Family
ID=11165196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880004742A KR970004051B1 (ko) | 1987-04-24 | 1988-04-25 | 항-진균활성도를 가지는 β-시클로 덱스트린 착염 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5422347A (ko) |
| EP (1) | EP0288019B1 (ko) |
| JP (1) | JP2720929B2 (ko) |
| KR (1) | KR970004051B1 (ko) |
| DE (1) | DE3874941T2 (ko) |
| IT (1) | IT1203968B (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1067639A (ja) * | 1996-08-26 | 1998-03-10 | Shiseido Co Ltd | ビタミンｅ−ビタミンｃリン酸ジエステル／シクロデキストリン包接物及び該包接物を配合した皮膚外用剤 |
| US6824763B2 (en) | 2002-05-30 | 2004-11-30 | Kimberly-Clark Worldwide, Inc. | Anti-fungal powder having enhanced excipient properties |
| US20110160266A1 (en) * | 2008-08-29 | 2011-06-30 | The Uab Research Foundation | Novel Anti-Arrhythmia Agent |
| US10426744B2 (en) * | 2016-04-08 | 2019-10-01 | Harrow Health, Inc. | Anti-fungal compositions for treating nails and methods for fabricating and using thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) * | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| US3453259A (en) * | 1967-03-22 | 1969-07-01 | Corn Products Co | Cyclodextrin polyol ethers and their oxidation products |
| DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
-
1987
- 1987-04-24 IT IT20256/87A patent/IT1203968B/it active
-
1988
- 1988-04-20 DE DE8888106260T patent/DE3874941T2/de not_active Expired - Fee Related
- 1988-04-20 EP EP88106260A patent/EP0288019B1/en not_active Expired - Lifetime
- 1988-04-23 JP JP63099353A patent/JP2720929B2/ja not_active Expired - Lifetime
- 1988-04-25 KR KR1019880004742A patent/KR970004051B1/ko not_active IP Right Cessation
-
1990
- 1990-09-05 US US07/579,084 patent/US5422347A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3874941D1 (de) | 1992-11-05 |
| JP2720929B2 (ja) | 1998-03-04 |
| DE3874941T2 (de) | 1993-02-18 |
| KR970004051B1 (ko) | 1997-03-24 |
| IT1203968B (it) | 1989-02-23 |
| EP0288019A1 (en) | 1988-10-26 |
| EP0288019B1 (en) | 1992-09-30 |
| JPS6425766A (en) | 1989-01-27 |
| IT8720256A0 (it) | 1987-04-24 |
| US5422347A (en) | 1995-06-06 |
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