[go: up one dir, main page]

KR880007542A - 순수 결정성 생성물의 제조방법 - Google Patents

순수 결정성 생성물의 제조방법 Download PDF

Info

Publication number
KR880007542A
KR880007542A KR870014661A KR870014661A KR880007542A KR 880007542 A KR880007542 A KR 880007542A KR 870014661 A KR870014661 A KR 870014661A KR 870014661 A KR870014661 A KR 870014661A KR 880007542 A KR880007542 A KR 880007542A
Authority
KR
South Korea
Prior art keywords
product
pure crystalline
temperature
crystallization
cephalosporin
Prior art date
Application number
KR870014661A
Other languages
English (en)
Inventor
지오반니 본판티
Original Assignee
지오반니 본판티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 지오반니 본판티 filed Critical 지오반니 본판티
Publication of KR880007542A publication Critical patent/KR880007542A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/18—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

순수 결정성 생성물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 무정형 또는 불안정 결정상태의 출발 목적 생성물을 1 또는 2단계로 무수 또는 함수 에탄올로 처리하여 불용성 불순물을 제거하고 목적하는 생성물을 순수한 결정상태로 침전시킴을 특징으로 하여, 순수한 결정성 생성물을 제조하는 방법.
  2. 제1항에 있어서, 공지의 방법에 따라 불안정 결정상태로 수득된 페니실린 및 세팔로스포린 그룹중에서 선택된 출발물질을 생성물의 용해온도와 결정화 온도 사이의 온도에서 무수 또는 함수 에탄올로 건조 처리한 후, 결정화 반응용액을 냉각시켜 순수한 결정 상태의 생성물을 수득함을 특징으로 하는 방법.
  3. 제1항에 있어서, 공지의 방법에 따라 무정형으로 제조된 페니실린 및 세팔로스포린 그룹 중에서 선택된 출발물질을 생성물의 용해온도와 결정화 온도 사이의 온도에서, 2단계에 걸쳐 에탄올로 건조 처리하여 순수한 결정상태의 생성물을 분리함을 특징으로 하는 방법.
  4. 제1항 내지 3항중 어느 한 항에 있어서, 생성물의 에탄올성 욕액을 여과함으로써 결정화하기 전에 불용성 불순물을 제거함을 특징으로 하는 방법.
  5. 제1항 내지 4항중 어느 하나의 방법으로 수득한 순수한 결정상의 페니실린.
  6. 제1항 내지 4항중 어느 하나의 방법으로 수득한 순수한 결정상의 세팔로스포린.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870014661A 1986-12-23 1987-12-22 순수 결정성 생성물의 제조방법 KR880007542A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22852A/86 1986-12-23
IT8622852A IT1214587B (it) 1986-12-23 1986-12-23 Metodo per la produzione diprodotti cristallini puri.

Publications (1)

Publication Number Publication Date
KR880007542A true KR880007542A (ko) 1988-08-27

Family

ID=11201177

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870014661A KR880007542A (ko) 1986-12-23 1987-12-22 순수 결정성 생성물의 제조방법

Country Status (5)

Country Link
US (1) US4912211A (ko)
EP (1) EP0273156A3 (ko)
JP (1) JPS63166839A (ko)
KR (1) KR880007542A (ko)
IT (1) IT1214587B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142042A (en) * 1989-01-23 1992-08-25 Purzer Pharmaceutical Co., Ltd. Process for preparing well crystallized alkali metal salts of 3, 7-substituted 7-aminocephalosporanic acid derivatives
DE3911322A1 (de) * 1989-04-07 1990-10-11 Hoechst Ag Verfahren zur herstellung von cefodizim-dinatrium
ZA941586B (en) * 1993-03-12 1995-09-07 Upjohn Co Crystalline ceftiofur free acid
AU679800B2 (en) * 1993-11-06 1997-07-10 Taiho Pharmaceutical Co., Ltd. Crystalline penicillin derivative, and its production and use
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
ES2134128B1 (es) * 1997-01-17 2000-05-01 Antibioticos Sa Un procedimiento de reduccion de los niveles residuales de disolventes, presentes en las composiciones farmaceuticas, en particular en los antibioticos y antibioticos obtenidos segun el mismo.
AU728627B2 (en) * 1997-08-25 2001-01-11 Otsuka Chemical Co. Ltd. Cephalosporin crystals and process for their preparation
AR014939A1 (es) 1997-12-22 2001-04-11 Astrazeneca Ab Proceso para purificar una solucion de un ester profarmaco de ampicilina
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
RU2457211C1 (ru) * 2011-01-12 2012-07-27 Общество С Ограниченной Ответственностью Нпф "Файн Кемикалс" Способ получения натриевой соли 6-[3-(2-хлор-6-фторфенил)-5-метилизоксазол-4-карбамино]-пенициллановой кислоты
CN103288850B (zh) * 2011-06-17 2015-09-23 桂林理工大学 氟氯西林钠无定形晶型物的制备方法
CN103717607A (zh) * 2012-09-12 2014-04-09 海南卫康制药(潜山)有限公司 头孢呋辛钠新晶型化合物及其组合物粉针
CN102964356B (zh) * 2012-12-25 2015-06-17 菏泽睿智科技开发有限公司 一种氟氯西林钠的合成方法
CN105153196B (zh) * 2015-09-15 2018-01-16 桂林南药股份有限公司 一种氟氯西林钠晶型、制备方法及应用
CN108659007B (zh) * 2018-07-23 2020-08-25 华北制药集团先泰药业有限公司 一种双氯西林钠柱形晶体的制备方法
CN111548357B (zh) * 2020-04-16 2021-07-13 华北制药河北华民药业有限责任公司 一种高纯度头孢唑林钠及其药物制剂的制备方法
CN113788843B (zh) * 2021-09-30 2022-07-19 海南海灵化学制药有限公司 一种注射用头孢呋辛钠的制备工艺

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2128207A1 (en) * 1971-06-07 1972-12-14 Purificn of org cpds - by meta-dissoln,esp for substd 2-mercapto-benzthiazoles,nitrones and organometallic cpds
US4061853A (en) * 1975-12-09 1977-12-06 Ciba-Geigy Corporation Virtually solvent-free crystal form of the sodium salt of Cephacetril

Also Published As

Publication number Publication date
IT1214587B (it) 1990-01-18
IT8622852A0 (it) 1986-12-23
US4912211A (en) 1990-03-27
JPS63166839A (ja) 1988-07-11
EP0273156A3 (en) 1990-04-04
EP0273156A2 (en) 1988-07-06

Similar Documents

Publication Publication Date Title
KR880007542A (ko) 순수 결정성 생성물의 제조방법
BR9609055A (pt) Processos e dispositivos para a purificação de ácido tereftálico bruto e para a produção de ácido tereftálico.
BG31071A3 (en) Method for extraction of tereftalic acid by continuous ckystallisation
DE69330963D1 (de) Herstellung von aluminosilikatzeolithen
KR880002847A (ko) 형태학적으로 균일한 형태를 갖는 티아졸 유도체의 제조방법
BR9205884A (pt) Processo para a preparação de um ácido tereftálico purificado contendo ácido p-tolúico
FI952065A0 (fi) Foerfarande foer tillvaratagande av en kristalliserbar organisk foerening
UA7080A1 (uk) Спосіб одержання кристалічного торасеміду
FI871182A0 (fi) Foerfarande foer rening av glykolid.
US2588449A (en) Levulose dihydrate
KR910002865A (ko) 피라노벤즈옥사디아졸 화합물 및 그 광학적 분할방법
KR890016014A (ko) 고순도 카프로락탐의 제조방법
ES386356A1 (es) Un procedimiento para cristalizar un componente cristaliza-ble a partir de una solucion del mismo.
KR890011923A (ko) 스티렌계 중합체 성형품 및 제조방법
FR2414556A1 (fr) Procede de preparation d'hydrolysats d'amidon contenant du maltose, et de production de maltose par cristallisation a partir de ces hydrolysats
SU403670A1 (ru) Способ получения d-кальция пантотената
KR890700559A (ko) 적어도 99.5%의 순도를 가지는 파라-크시롤의 제조방법
SU636229A1 (ru) Способ очистки 5-сульфохлорида о-нафтохинондиазида
KR900004266A (ko) 약용꿀의 제조 방법(Methods of making nedicinal mel)
SU451446A1 (ru) Способ очистки веществ
ES8203961A1 (es) Un metodo para producir un sistema de enzima inmovilizada.
GB2012767A (en) Process for Preparing Maltose- Containing Starch Hydrolyzate and Crystallization of Maltose therefrom
SU599819A1 (ru) Способ очистки веществ от примесей, понижающих температуру кристаллизации
JPS57192376A (en) Purification of 2-mercaptothiazolines
SU461055A1 (ru) Способ регенрации серной кислоты

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19871222

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid