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KR850008450A - 수포의 안정화 방법 - Google Patents

수포의 안정화 방법 Download PDF

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Publication number
KR850008450A
KR850008450A KR1019850003629A KR850003629A KR850008450A KR 850008450 A KR850008450 A KR 850008450A KR 1019850003629 A KR1019850003629 A KR 1019850003629A KR 850003629 A KR850003629 A KR 850003629A KR 850008450 A KR850008450 A KR 850008450A
Authority
KR
South Korea
Prior art keywords
micelle
gel matrix
polymerizable
polymerizable gel
protective
Prior art date
Application number
KR1019850003629A
Other languages
English (en)
Inventor
윙-유 틴 죠지
Original Assignee
원본미기재
베스타 리서치 인코포레이팃드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 베스타 리서치 인코포레이팃드 filed Critical 원본미기재
Publication of KR850008450A publication Critical patent/KR850008450A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1227—Micelles, e.g. phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Ceramic Products (AREA)

Abstract

내용없음

Description

수포의 안정화 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
본 발명 방법에 의한 수포의 안정화도를 도시한 도면.

Claims (18)

  1. 액체로 변화되어 보호 갤 표면을 현탁수용액으로 변화시킬 수 있는 중합성 겔 매트릭스에 미셀입자를 현탁시켜 그 미셀입자 주위에 보호 겔 표면을 형성시키는 것을 특징으로 하는 미셀입자의 안정화 및 수명증대 방법.
  2. 제1항에 있어서, 상기 중합성 겔 매트릭스가 거의 실온 또는 그 이상의 온동에서 용융하여 상기 보호 겔 표면을 수용액으로 변화시킬 수 있는 다당류 또는 폴리펩티드인 방법.
  3. 제2항에 있어서, 상기 중합성 겔 매트릭스가 젤라틴인 방법.
  4. 제2항에 있어서, 상기 중합성 겔 매트릭스가 아가로우즈인 방법.
  5. 제1항 또는 제2항에 있어서, 상기 미셀입자가 인지질인 방법.
  6. 제5항에 있어서, 상기 수포의 내부에 치료제를 포함시키는 방법.
  7. 제1항, 제2항 또는 제5항에 있어서, 상기 중합성 겔 매트릭스 약 0.5중량% 내지 약 10중량%의 겔을 함유하는 방법.
  8. 제7항에 있어서, 상기 중합성 겔 매트릭스가 약 1중량% 내지 약 5중량%의 겔을 함유하는 방법.
  9. 제1항,제2항 또는 제5항에 있어서, 상기 중합성 겔 매트릭스를 액체로 변화시킴으로써 그 갤 매트릭스는 현탁수용액으로 변화시키고, 이어서 미셀입자에는 방사성 핵종으로 표지를 붙이는 방법.
  10. 액체로 변화되어 보호 겔 표면을 현탁수용액으로 변화시킬 수 있는 중합성 겔 매트릭스에 미셀입자를 현탁시켜 그 미셀입자 주위에 보호 겔 표면이 형성된 미셀입자.
  11. 제10항에 있어서, 상기 중합성 겔 매트릭스가 거의 실온 또는 그 이상의 온도에서 용융하여 상기 보호겔 표면을 수용액으로 변화시킬 수 있는 다당류 또는 폴리펩티드인 미셀입자.
  12. 제11항에 있어서, 상기 중합성 겔 매트릭스가 젤라틴인 미셀입자.
  13. 제11항에 있어서, 상기 중합성 겔 매트릭스가 아가로우즈인 미셀입자.
  14. 제11항에 있어서, 상기 미셀입자가 인지질인 미셀입자.
  15. 제14항에 있어서, 상기 수포의 내부에 치료제를 포함시키는 미셀입자.
  16. 제10항, 제11항 또는 제14항에 있어서, 상기 중합성 겔 매트릭스 약 0.5중량% 내지 약 10중량%의 겔을 함유하는 미셀입자.
  17. 제16항에 있어서, 상기 중합성 겔 매트릭스가 약 1중량% 내지 약 5중량%의 겔을 함유하는 미셀입자.
  18. 제10항, 제11항 또는 제14항에 있어서, 상기 중합성 겔 매트릭스는 현탁수용액으로 변화되어 있고, 미셀입자에는 방사성 핵종으로 표지를 붙인 미셀입자.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850003629A 1984-05-25 1985-05-25 수포의 안정화 방법 KR850008450A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61425584A 1984-05-25 1984-05-25
US614255 1984-05-25

Publications (1)

Publication Number Publication Date
KR850008450A true KR850008450A (ko) 1985-12-18

Family

ID=24460474

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003629A KR850008450A (ko) 1984-05-25 1985-05-25 수포의 안정화 방법

Country Status (13)

Country Link
EP (1) EP0162724B1 (ko)
JP (1) JPH0696515B2 (ko)
KR (1) KR850008450A (ko)
AT (1) ATE93387T1 (ko)
AU (1) AU576363B2 (ko)
CA (1) CA1263311A (ko)
DE (1) DE3587541T2 (ko)
DK (1) DK164483C (ko)
ES (1) ES8608862A1 (ko)
HU (1) HU200698B (ko)
IE (1) IE61706B1 (ko)
IL (1) IL75315A (ko)
ZA (1) ZA853943B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US4740375A (en) * 1985-02-25 1988-04-26 Technology Unlimited, Inc. Gelcores
EP0199362A3 (en) * 1985-04-26 1987-10-07 Massachusetts Institute Of Technology System and apparatus for delayed and pulsed release of biologically active substances
GB8522963D0 (en) * 1985-09-17 1985-10-23 Biocompatibles Ltd Microcapsules
US4839111A (en) * 1987-02-02 1989-06-13 The University Of Tennessee Research Corporation Preparation of solid core liposomes
FR2620333B1 (fr) * 1987-09-15 1990-01-05 Inst Nat Sante Rech Med Liposomes, leur procede de preparation et application desdits liposomes comme vecteur de produits
US5006473A (en) * 1988-08-09 1991-04-09 Abbott Laboratories Electrophoresis method using vesicles
US5064655A (en) * 1989-02-24 1991-11-12 Liposome Technology, Inc. Liposome gel composition and method
SI9620107A (sl) * 1995-08-10 1998-10-31 Kazunori Kataoka Blok polimer, ki ima funkcionalne skupine na obeh svojih koncih
US5962015A (en) * 1997-05-02 1999-10-05 Kobo Products S.A.R.L. Stabilized liposomes
FR2764507B1 (fr) * 1997-06-11 2000-10-20 Lipogel Sarl Compositions pulverulentes de liposomes unilamellaires, leur procede de preparation et leurs applications comme complements nutritionnels et comme complements nutritionnels et comme medicaments
US6048546A (en) * 1997-07-31 2000-04-11 Sandia Corporation Immobilized lipid-bilayer materials
AU5731200A (en) * 1999-06-11 2001-01-02 Endorex Corporation Adjuvant-containing polymerized liposomes for oral, mucosal or intranasal vaccination
US20050129751A1 (en) * 2003-12-16 2005-06-16 Rothenberg Barry E. Drug delivery compositions and methods
ATE553748T1 (de) 2006-09-22 2012-05-15 Mivital Ag Emulsionen enthaltend gummi arabicum
US20110020428A1 (en) * 2007-11-15 2011-01-27 Qun Zeng Gel-stabilized liposome compositions, methods for their preparation and uses thereof
KR101685218B1 (ko) * 2008-11-14 2016-12-09 아처 다니엘 미드랜드 캄파니 유기젤 조성물 및 이의 생산 공정
FR2943252B1 (fr) * 2009-03-17 2011-08-05 Dermo Cosmetique Animale Lab De Composition dermo-cosmetique
BR112012029040A2 (pt) 2010-05-14 2016-08-02 Archer Daniels Midland Co composição de organogel de fosfolipideo estruturado termorreversível comestível para uso em produto alimentício, método de estruturar uma fase orgânica comestível, produto ou ingrediente alimentício, composição, método de carregar um organogel de fosfolipídeo estruturado termorreversível comestível, método de revestir um alimento e composição de organogel de fosfolipídeo estruturado termorreversivel comestível para uso em um produto alimentício
JP2012102043A (ja) * 2010-11-10 2012-05-31 Konica Minolta Holdings Inc 単胞リポソームの製造方法、単胞リポソームの分散液とその乾燥粉末及びそれらの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069307B1 (de) * 1981-07-02 1986-03-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Liposomenlösungen
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
US4608278A (en) * 1983-06-22 1986-08-26 The Ohio State University Research Foundation Small particule formation and encapsulation
FR2548902B1 (fr) * 1983-07-13 1986-04-11 Guerbet Sa Gel pour embolisation therapeutique
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions

Also Published As

Publication number Publication date
DE3587541T2 (de) 1993-12-23
JPS60258109A (ja) 1985-12-20
DK234185D0 (da) 1985-05-24
DK164483B (da) 1992-07-06
ES543495A0 (es) 1986-09-01
DE3587541D1 (de) 1993-09-30
EP0162724A2 (en) 1985-11-27
IE851306L (en) 1985-11-25
DK234185A (da) 1985-11-26
AU576363B2 (en) 1988-08-25
HU200698B (en) 1990-08-28
ATE93387T1 (de) 1993-09-15
ZA853943B (en) 1988-12-28
IE61706B1 (en) 1994-11-30
HUT38266A (en) 1986-05-28
JPH0696515B2 (ja) 1994-11-30
EP0162724A3 (en) 1986-07-23
IL75315A (en) 1991-07-18
EP0162724B1 (en) 1993-08-25
IL75315A0 (en) 1985-09-29
ES8608862A1 (es) 1986-09-01
AU4285685A (en) 1985-12-12
CA1263311A (en) 1989-11-28
DK164483C (da) 1992-11-16

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