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KR850006939A - 아실트리펩타이드의 제조방법 - Google Patents

아실트리펩타이드의 제조방법 Download PDF

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Publication number
KR850006939A
KR850006939A KR1019850002106A KR850002106A KR850006939A KR 850006939 A KR850006939 A KR 850006939A KR 1019850002106 A KR1019850002106 A KR 1019850002106A KR 850002106 A KR850002106 A KR 850002106A KR 850006939 A KR850006939 A KR 850006939A
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KR
South Korea
Prior art keywords
preparing acyl
formula
preparing
catalytic hydrogenation
acyl tripeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019850002106A
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English (en)
Other versions
KR870000372B1 (ko
Inventor
리 아이브스(외 1) 제프리
Original Assignee
윌리엄 데이비스 헌
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 윌리엄 데이비스 헌, 화이자 인코포레이티드 filed Critical 윌리엄 데이비스 헌
Publication of KR850006939A publication Critical patent/KR850006939A/ko
Application granted granted Critical
Publication of KR870000372B1 publication Critical patent/KR870000372B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/16—Eight-membered rings
    • C07D313/18—Eight-membered rings not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

아실트리펩타이드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 일반식(Ⅰ′)의 화합물을 탄소상 팔라듐상에서 촉매적으로 수소 첨가시키고, 임으로는 염형성시켜 일반식(Ⅰ)의 화합물 또는 약제학적으로 허용가능한 그의 염을 제조하는 방법.
    상기식에서, R0는 탄소수 1 내지 6의 알킬이고, X는 1 내지 4의 정수이고, Bz은 벤질이고, Z은 벤질 옥시카보닐이다.
  2. 제1항에 있어서, 촉매적 수소첨가반응을 수성 아세트산 용매중에서 수행하는 방법.
  3. 제2항에 있어서, R0가 헥실이고 X가 3 또는 4인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850002106A 1984-03-30 1985-03-29 아실트리펩타이드의 제조방법 Expired KR870000372B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US595169 1984-03-30
US06/595,169 US4565653A (en) 1984-03-30 1984-03-30 Acyltripeptide immunostimulants
US595,169 1984-03-30

Publications (2)

Publication Number Publication Date
KR850006939A true KR850006939A (ko) 1985-10-25
KR870000372B1 KR870000372B1 (ko) 1987-03-06

Family

ID=24382038

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850002106A Expired KR870000372B1 (ko) 1984-03-30 1985-03-29 아실트리펩타이드의 제조방법

Country Status (20)

Country Link
US (1) US4565653A (ko)
EP (1) EP0157572A3 (ko)
JP (1) JPS60224699A (ko)
KR (1) KR870000372B1 (ko)
AU (2) AU552919B2 (ko)
CA (1) CA1270098A (ko)
DD (1) DD239406A5 (ko)
DK (1) DK142485A (ko)
EG (1) EG17928A (ko)
ES (1) ES8605821A1 (ko)
FI (1) FI851271L (ko)
GR (1) GR850783B (ko)
HU (1) HU198086B (ko)
IL (1) IL74758A (ko)
NO (1) NO851278L (ko)
NZ (1) NZ211634A (ko)
PH (1) PH21303A (ko)
PL (1) PL252659A1 (ko)
PT (1) PT80181B (ko)
ZA (1) ZA852335B (ko)

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DE3820528A1 (de) * 1988-06-16 1989-12-21 Bayer Ag Mittel zur insekten- und milbenabwehr
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US5248820A (en) * 1989-02-21 1993-09-28 Pfizer Inc. Crystalline N-(S-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, and processes and intermediates therefor
US5134225A (en) * 1989-02-21 1992-07-28 Pfizer Inc. Processes and intermediates for N-(S-3-alkyl-heptanoyl)-D-gamma-glutamyl-D-alanine
US5185464A (en) * 1989-02-21 1993-02-09 Pfizer Inc. Crystalline N-(S-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, and processes and intermediates therefor
US5136020A (en) * 1989-02-21 1992-08-04 Pfizer Inc. Crystalline n-(s-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, and processes and intermediates therefor
US5798387A (en) * 1992-10-15 1998-08-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Amino acid derivatives
EP0617009B1 (en) * 1992-10-15 1999-09-08 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Novel amino acid derivative
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US7399613B2 (en) * 2001-10-10 2008-07-15 Neose Technologies, Inc. Sialic acid nucleotide sugars
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Also Published As

Publication number Publication date
PH21303A (en) 1987-09-28
EP0157572A2 (en) 1985-10-09
EG17928A (en) 1991-08-30
AU5647686A (en) 1986-09-04
DD239406A5 (de) 1986-09-24
US4565653A (en) 1986-01-21
DK142485D0 (da) 1985-03-29
KR870000372B1 (ko) 1987-03-06
AU566460B2 (en) 1987-10-22
ES8605821A1 (es) 1986-04-01
FI851271A7 (fi) 1985-10-01
IL74758A0 (en) 1985-06-30
JPS60224699A (ja) 1985-11-09
NZ211634A (en) 1988-10-28
DK142485A (da) 1985-10-01
PT80181B (en) 1987-03-20
PT80181A (en) 1985-04-01
CA1270098A (en) 1990-06-05
ES541620A0 (es) 1986-04-01
NO851278L (no) 1985-10-01
PL252659A1 (en) 1985-11-19
ZA852335B (en) 1986-11-26
FI851271A0 (fi) 1985-03-29
HUT37443A (en) 1985-12-28
GR850783B (ko) 1985-11-25
IL74758A (en) 1988-06-30
HU198086B (en) 1989-07-28
AU4052385A (en) 1985-10-03
FI851271L (fi) 1985-10-01
EP0157572A3 (en) 1987-01-07
AU552919B2 (en) 1986-06-26

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