KR850004963A - 피리딘 카복실산 유도체의 제조방법 - Google Patents
피리딘 카복실산 유도체의 제조방법 Download PDFInfo
- Publication number
- KR850004963A KR850004963A KR1019830006229A KR830006229A KR850004963A KR 850004963 A KR850004963 A KR 850004963A KR 1019830006229 A KR1019830006229 A KR 1019830006229A KR 830006229 A KR830006229 A KR 830006229A KR 850004963 A KR850004963 A KR 850004963A
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogen
- chlorine
- methyl
- carboxylic acid
- acid derivative
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical class OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 title claims 2
- 238000000034 method Methods 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- HXELGNKCCDGMMN-UHFFFAOYSA-N [F].[Cl] Chemical group [F].[Cl] HXELGNKCCDGMMN-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- ZWLPBLYKEWSWPD-UHFFFAOYSA-N o-toluic acid Chemical class CC1=CC=CC=C1C(O)=O ZWLPBLYKEWSWPD-UHFFFAOYSA-N 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims (6)
- 다음 구조식(Ⅱ)의 피리딘카복실산 유도체에 다음 구조식(Ⅲ)의 디치환톨루인산 또는 그 염을 반응시켜 다음 구조식(Ⅰ)의 프탈리딜피리딘 카복실산 에스테르를 제조하는 방법.상기식에서 B는 아세톡시 또는 다음 일반식으로 표기되는 아닐린기이다.R1및 R2는 각각 수소염소, 메칠 또는 트리플루오로 메칠기중에서 선택될 수 있다.D는 수소 또는 불소, 염소, 브롬, 요오드이다.R 및 R3는 각각 수소, 칼륨, 나트륨의 알칼리금속이며, X는 불소 염소, 브롬, 요오드이거나 아릴설포닐옥시 또는 알킬설포닐옥시기이다.
- D가 수소인 경우의 제1항의 제조방법.
- R1이 수소이고, R2가 트리플루오로메칠인 경우의 제1항의 제조방법.
- R1이 메칠, R2가 염소인 경우의 제2항 또는 제2항의 제조방법.
- R1및 R2가 각각 메칠인 경우의 제1항 또는 제2항의 제조방법.
- X가 브롬인 경우의 제1항, 제2항, 제3항, 제4항 또는 제5항의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019830006229A KR860000591B1 (ko) | 1983-12-28 | 1983-12-28 | 피리딘 카복실산 유도체의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019830006229A KR860000591B1 (ko) | 1983-12-28 | 1983-12-28 | 피리딘 카복실산 유도체의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR850004963A true KR850004963A (ko) | 1985-08-19 |
| KR860000591B1 KR860000591B1 (ko) | 1986-05-17 |
Family
ID=19230738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830006229A KR860000591B1 (ko) | 1983-12-28 | 1983-12-28 | 피리딘 카복실산 유도체의 제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR860000591B1 (ko) |
-
1983
- 1983-12-28 KR KR1019830006229A patent/KR860000591B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR860000591B1 (ko) | 1986-05-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR880000433A (ko) | 이미다조피리딘 및 중간체 화합물의 제조방법 | |
| KR850004500A (ko) | 2-플루오로-17β-에스트라디올의 제조방법 | |
| KR840000463A (ko) | 광학적으로 활성인 1-방향족 그룹으로 치환된-1- 알카논의 제조방법 | |
| KR830006906A (ko) | 시클로로프로판 카르복실레이트의 제조방법 | |
| KR860000236A (ko) | 유기산의 트리테르페닐의 에스테르의 제조방법 | |
| KR860003239A (ko) | 퀴놀론 카복실산 유도체의 제조방법 | |
| KR830006191A (ko) | 살균제로 유용한 n-알키닐-2-(치환된 페녹시)부틸아미드의 제조방법 | |
| KR880009937A (ko) | 치환된 3-알킬퀴놀린-8-카르복실산의 제조방법 | |
| KR880011103A (ko) | 5-아미노-4,6-디할로게노피리딘의 제조방법 | |
| KR860001045A (ko) | 메발로노락톤의 나프틸 동족체의 제조방법 | |
| KR920006321A (ko) | 3-메틸피라졸의 제조방법 | |
| KR830004292A (ko) | 벤조구아나민 유도체의 제조방법 | |
| KR840004422A (ko) | 사이프로헵타딘-3-카복실산의 에스테르 및 관련 화합물의 제조방법 | |
| KR850004963A (ko) | 피리딘 카복실산 유도체의 제조방법 | |
| KR830001948A (ko) | 페니실린 설폭사이드의 제조방법 | |
| KR850004581A (ko) | α,α-디메틸페닐아세트아닐리드 유도체의 제조방법 | |
| KR850004961A (ko) | 소염진통작용을 갖는 살리실산 유도체의 제조방법 | |
| KR830001890A (ko) | 카바졸 유도체의 제조방법 | |
| KR850005411A (ko) | α-메틸-(6-펜옥시)-2- 피콜릴 사이클로프로판 카복실 레이트의 제조방법 | |
| KR860002454A (ko) | 살리실아미드 유도체의 제조방법 | |
| KR850006397A (ko) | 치환된 이소크로만 및 옥세핀의 제조방법 | |
| KR880001636A (ko) | 벤즈이미다졸 유도체의 제조 방법 | |
| KR840003639A (ko) | 이속사졸로피리미딘 유도체의 제조방법 | |
| KR870007094A (ko) | 벤조일아세트 산 에스테르 유도체의 제조방법 | |
| KR840001573A (ko) | 안트라닐산 에스테르의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19831228 |
|
| PA0201 | Request for examination | ||
| PG1501 | Laying open of application | ||
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19860201 Patent event code: PE09021S01D |
|
| G160 | Decision to publish patent application | ||
| PG1605 | Publication of application before grant of patent |
Comment text: Decision on Publication of Application Patent event code: PG16051S01I Patent event date: 19860419 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 19860730 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 19860829 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 19860829 End annual number: 3 Start annual number: 1 |
|
| PR1001 | Payment of annual fee |
Payment date: 19890222 Start annual number: 4 End annual number: 4 |
|
| PR1001 | Payment of annual fee |
Payment date: 19900116 Start annual number: 5 End annual number: 5 |
|
| PR1001 | Payment of annual fee |
Payment date: 19910212 Start annual number: 6 End annual number: 6 |
|
| PR1001 | Payment of annual fee |
Payment date: 19920122 Start annual number: 7 End annual number: 7 |
|
| PR1001 | Payment of annual fee |
Payment date: 19930119 Start annual number: 8 End annual number: 8 |
|
| PR1001 | Payment of annual fee |
Payment date: 19940215 Start annual number: 9 End annual number: 9 |
|
| PR1001 | Payment of annual fee |
Payment date: 19950330 Start annual number: 10 End annual number: 10 |
|
| PR1001 | Payment of annual fee |
Payment date: 19960130 Start annual number: 11 End annual number: 11 |
|
| PR1001 | Payment of annual fee |
Payment date: 19961224 Start annual number: 12 End annual number: 12 |
|
| PR1001 | Payment of annual fee |
Payment date: 19971229 Start annual number: 13 End annual number: 13 |
|
| FPAY | Annual fee payment |
Payment date: 19990512 Year of fee payment: 14 |
|
| PR1001 | Payment of annual fee |
Payment date: 19990512 Start annual number: 14 End annual number: 14 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |