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KR840009311A - 치환된 1,2,3-트리아지노 〔4´,5´ : 4,5〕 티에노〔2,3-b〕 퀴놀린-4(3H)-온의 제조방법 - Google Patents

치환된 1,2,3-트리아지노 〔4´,5´ : 4,5〕 티에노〔2,3-b〕 퀴놀린-4(3H)-온의 제조방법 Download PDF

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Publication number
KR840009311A
KR840009311A KR1019840002823A KR840002823A KR840009311A KR 840009311 A KR840009311 A KR 840009311A KR 1019840002823 A KR1019840002823 A KR 1019840002823A KR 840002823 A KR840002823 A KR 840002823A KR 840009311 A KR840009311 A KR 840009311A
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South Korea
Prior art keywords
hydrogen
compound
triazino
thieno
quinolin
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KR1019840002823A
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KR900002248B1 (ko
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알. 맥카티(외 1) 제임스
Original Assignee
개리 디 스트리트
메렐 다우 파마슈티칼스 인코포레이티드
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Publication of KR840009311A publication Critical patent/KR840009311A/ko
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Publication of KR900002248B1 publication Critical patent/KR900002248B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

치환된 1,2,3-트리아지노〔4′,5′:4,5〕티에노〔2,3-b〕퀴놀린-4(3H)-온의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식(Ⅱ)의 화합물을 아질산 나트륨과 아세트산 중에서 반응시켜 R이 수소인 화합물을 수득한 후, 임의로 이 화합물을 염기 및 알킬 요다이드 또는 브로마이드와 반응시켜 R이 알킬인 화합물을 수득함을 특징으로 하는 하기 일반식(Ⅰ)의 화합물의 제조방법.
    상기식에서 R은 수소 또는 탄소수 1내지 4의 알킬이고 R′및 R″는 이들 중 하나만이 수소일 수 있다는 조건하에 수소 또는 메톡시이거나, R′및 R″는 함께 메틸렌디옥시를 형성한다.
  2. 제1항에 있어서, 3-아미노-6,7-디메톡시티에노〔2,3-b〕퀴놀린-2-카복스아미드를 아질산 나트륨과 아세트산 중에서 반응시킴을 특징으로 하는, 8,9-디메톡시-1,2,3-트리아지노〔4′,5′:4,5〕티에노〔2,3-b〕퀴놀린-4(3H)-온의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840002823A 1983-05-23 1984-05-23 치환된 1,2,3-트리아지노[4',5':4,5] 티에노[2,3-b]퀴놀린-4(3H)-온 및 그의 제조방법 KR900002248B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US496800 1983-05-23
US06/496,800 US4496725A (en) 1983-05-23 1983-05-23 Substituted 1,2,3-triazino[4',5':4,5]-thieno[2,3-B]quinolin-4(3H)-ones

Publications (2)

Publication Number Publication Date
KR840009311A true KR840009311A (ko) 1984-12-26
KR900002248B1 KR900002248B1 (ko) 1990-04-07

Family

ID=23974193

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002823A KR900002248B1 (ko) 1983-05-23 1984-05-23 치환된 1,2,3-트리아지노[4',5':4,5] 티에노[2,3-b]퀴놀린-4(3H)-온 및 그의 제조방법

Country Status (19)

Country Link
US (1) US4496725A (ko)
EP (1) EP0126487B1 (ko)
JP (1) JPS59222493A (ko)
KR (1) KR900002248B1 (ko)
AT (1) ATE36713T1 (ko)
AU (1) AU558765B2 (ko)
CA (1) CA1227484A (ko)
DE (1) DE3473601D1 (ko)
DK (1) DK251284A (ko)
ES (1) ES8602010A1 (ko)
GR (1) GR82028B (ko)
HU (1) HU189898B (ko)
IE (1) IE57490B1 (ko)
IL (1) IL71881A (ko)
NO (1) NO842026L (ko)
NZ (1) NZ208205A (ko)
PH (1) PH19387A (ko)
PT (1) PT78624B (ko)
ZA (1) ZA843794B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581448A (en) * 1984-10-10 1986-04-08 Merrell Dow Pharmaceuticals Inc. Thienotriazines
DE4014171A1 (de) * 1990-05-03 1991-11-07 Basf Ag Cyanochinolinverbindungen
US6332287B1 (en) 1997-03-06 2001-12-25 Carroll M. Geraldson Plant cultivation apparatus and method
CN102757447B (zh) * 2011-07-05 2014-12-31 北京大学 一种尿素通道蛋白抑制剂及其制备方法与应用
ES2656972T3 (es) 2012-02-23 2018-03-01 Vanderbilt University Análogos de 5-aminotieno [2,3-c] piridazin-6-carboxamida como moduladores alostéricos positivos del receptor de acetilcolina muscarínico M4
WO2015027214A1 (en) 2013-08-23 2015-02-26 Vanderbilt University Substituted thieno[2,3-c]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239887A (en) * 1979-10-31 1980-12-16 Usv Pharmaceutical Corporation Pyridothienotriazines

Also Published As

Publication number Publication date
NZ208205A (en) 1986-08-08
ATE36713T1 (de) 1988-09-15
PT78624A (en) 1984-06-01
IE841254L (en) 1984-11-23
KR900002248B1 (ko) 1990-04-07
HU189898B (en) 1986-08-28
GR82028B (ko) 1984-12-12
DK251284D0 (da) 1984-05-22
CA1227484A (en) 1987-09-29
ES532698A0 (es) 1985-11-01
PT78624B (en) 1986-06-18
IL71881A0 (en) 1984-09-30
EP0126487A3 (en) 1985-07-31
NO842026L (no) 1984-11-26
ZA843794B (en) 1984-12-24
DE3473601D1 (en) 1988-09-29
IL71881A (en) 1987-07-31
PH19387A (en) 1986-04-07
ES8602010A1 (es) 1985-11-01
AU2844784A (en) 1984-11-29
HUT34199A (en) 1985-02-28
US4496725A (en) 1985-01-29
EP0126487A2 (en) 1984-11-28
IE57490B1 (en) 1992-10-07
JPS59222493A (ja) 1984-12-14
AU558765B2 (en) 1987-02-05
DK251284A (da) 1984-11-24
EP0126487B1 (en) 1988-08-24

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