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KR840008013A - 퀴놀론 카복실산의 제조방법 - Google Patents

퀴놀론 카복실산의 제조방법 Download PDF

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Publication number
KR840008013A
KR840008013A KR1019840000914A KR840000914A KR840008013A KR 840008013 A KR840008013 A KR 840008013A KR 1019840000914 A KR1019840000914 A KR 1019840000914A KR 840000914 A KR840000914 A KR 840000914A KR 840008013 A KR840008013 A KR 840008013A
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KR
South Korea
Prior art keywords
carbon atoms
compound
formula
cyano
represents hydrogen
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KR1019840000914A
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English (en)
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KR870000891B1 (ko
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페터젠(외 3) 우베
Original Assignee
귄테르 페터스, 칼-루드빅 쉬미트
바이엘 아크티엔 게젤샤프트
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Application filed by 귄테르 페터스, 칼-루드빅 쉬미트, 바이엘 아크티엔 게젤샤프트 filed Critical 귄테르 페터스, 칼-루드빅 쉬미트
Publication of KR840008013A publication Critical patent/KR840008013A/ko
Priority to KR1019870002923A priority Critical patent/KR870001004B1/ko
Application granted granted Critical
Publication of KR870000891B1 publication Critical patent/KR870000891B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음.

Description

퀴놀론 카복실산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키거나, 일반식(Ⅱ)의 화합물을 일반식(Ⅳ)의 화합물과 반응시키거나, 일반식(Ⅴ)의 화합물을 알칼리 또는 산 조건하에서, 또는 R′가 벤질인 경우에는 가수소분해조건하에서 처리함을 특징으로 하여 일반식(I)의 퀴놀론카복실산 및 그의 약제학적으로 유용한 산 부가염, 알칼리금속염, 알칼리 토금속염 및 수화물을 제조하는 방법.
    상기식서 A는 탄소수 1내지 6의 직쇄 또는 측쇄알킬렌 또는 라디칼을 나타내고; R1은 알킬부위가 탄소수 1내지 6인 알콕시카보닐, 벤질옥시카보닐, 카복실, 임의로 치환된 카바모일, 시아노, 디알콕시포스포닐 또는 알킬부위가 탄소수 1내지 4인 알킬설포닐을 나타내며, R2가 수소, 알킬부위가 탄소수 1내지 6인 알콕시카보닐, 벤질옥시카보닐, 임의로 치환된 카바모일, 시아노, 염소, 아성틸, 탄소수 1 내지 3의 알킬 또는 페닐을 나타내거나, R1및 R2와 이들이 치환된 탄소원자가 함께 2-옥소-테트라 하이드로 푸릴환을 형성할 수 있고; R3,R4,R5및 R6는 동일하거나 다르며, 수소, 메틸, 에틸 또는 n-또는 l-프로필을 나타내며;X는 수소, 할로겐(바람직하게는 불소 또는 염소), 또는 니트로를 나타내고; Y는 할로겐(바람직하게는 염소,브롬 또는 요오드), CH3O-SO2-O, C2H5O-SO2-O, 메톡시 또는에톡시를 나타내며; R′는 탄소수 1내지 6의 알킬 또는 벤질을 나타낸다.
  2. 제1항에 있어서, A가 탄소수 1내지 5의 직쇄 또는 측쇄 알킬렌 또는을 나타내고; R1이 알킬 부위가 탄소수 1 내지 5인 알콕시카보닐, 벤질옥시카보닐, 카복실, 1 또는 2개의 메틸 또는 에틸라디칼에 의해 임의로 치환된 카바모일, 시아노, 메틸 설포닐 또는 에틸설포닐을 나타내고, R2가 수소, 알킬부위가 탄소수 1 내지 5인 알콕시카보닐, 벤질옥시카보닐, 카바모일, 시아노, 염소, 아세틸, 탄소수 1또는 2인 알킬 또는 페닐을 나타내거나, R1및 R2와 이들이 치환된 탄소원자가 함께 2-옥소-테트라하이드로푸릴환을 형성할수 있음; R3,R4,R5및 R6가 수소, 메틸 또는 에틸을 나타내고; X가 수소, 불소 또는 니트로를 나타내는 일반식(I)의 퀴놀론카복실 산을 제조하는 방법.
  3. 제1항에 있어서, A가 탄소수 1내지 5의 직쇄 알킬렌 또는를 나타내고; R1이 알킬부위가 탄소수 1내지 4인 알콕시카보닐, 벤질옥시카보닐, 카복실, 카바모일, 시아노 또는 메틸설포닐을 나타내고, R2가 수소, 알킬부위가 탄소수 1내지 3인 알콕시카보닐, 시아노, 염소, 아세틸 또는 페닐을 나타내거나, R1및 R2와 이들이 치환된 탄소원자가 함께 2-옥소-테트라하이드로-3-푸릴환을 형성할 수 있으며; R3가 수소, 메틸 또는 에틸을 나타내고; R4가 수소를 나타내며; R5가 수소 또는 메틸을 나타내고; R6가 수소를 나타내며; X가 수소, 불소, 염소 또는 니트로를 나타내는 일반식(I)의 퀴놀론카복실산을 제조하는 방법.
  4. 제1항에 있어서, 1-사이클로프로필-6-플우오로-1,4-디하이드로-4-옥소-7-{4-[2-옥소-1-(메톡시카보닐)-1-프로필]-1-프로필-1-피페라지닐}-3-퀴놀린카복실 산을 제조하는 방법.
  5. 제1항에 있어서, 7-[4-(2-클로로-2-시아노-에틸)-1-피페라지닐]-1-사이클로프로필-6-플루오로-1,4-디하이드로-4-옥소-3-퀴놀린카복실 산을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000914A 1983-02-25 1984-02-24 퀴놀론 카복실산의 제조방법 Expired KR870000891B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019870002923A KR870001004B1 (ko) 1983-02-25 1987-03-30 퀴놀론 카복실산의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3306772.4 1983-02-25
DE19833306772 DE3306772A1 (de) 1983-02-25 1983-02-25 Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019870002923A Division KR870001004B1 (ko) 1983-02-25 1987-03-30 퀴놀론 카복실산의 제조방법

Publications (2)

Publication Number Publication Date
KR840008013A true KR840008013A (ko) 1984-12-12
KR870000891B1 KR870000891B1 (ko) 1987-05-02

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KR1019840000914A Expired KR870000891B1 (ko) 1983-02-25 1984-02-24 퀴놀론 카복실산의 제조방법

Country Status (21)

Country Link
US (1) US4559342A (ko)
EP (1) EP0117474B1 (ko)
JP (1) JPS59157068A (ko)
KR (1) KR870000891B1 (ko)
AR (1) AR244669A1 (ko)
AT (1) ATE23152T1 (ko)
AU (1) AU562184B2 (ko)
CA (1) CA1216849A (ko)
DE (2) DE3306772A1 (ko)
DK (1) DK103284A (ko)
ES (1) ES530045A0 (ko)
FI (1) FI83955C (ko)
GR (1) GR79988B (ko)
HU (1) HU192398B (ko)
IE (1) IE56924B1 (ko)
IL (1) IL71036A (ko)
NO (1) NO840557L (ko)
NZ (1) NZ207238A (ko)
PH (3) PH21906A (ko)
PT (1) PT78114B (ko)
ZA (1) ZA841375B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306772A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3308908A1 (de) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3504643A1 (de) * 1985-02-12 1986-08-14 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-chinolin carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
IT1200470B (it) * 1985-05-10 1989-01-18 Schering Spa Composti ad attivita' antibatterica,loro preparazione e composizioni farmaceutiche relative
ATE72668T1 (de) * 1985-09-24 1992-03-15 Hoffmann La Roche Chinolinderivate.
EP0224121A3 (en) * 1985-11-19 1987-11-11 ROTTAPHARM S.p.A. 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPH0811749B2 (ja) * 1986-03-06 1996-02-07 富山化学工業株式会社 新規なキノリン誘導体およびその塩
DE3902079A1 (de) * 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
EP0338372A3 (en) * 1988-04-22 1991-10-09 American Cyanamid Company Solubilized pro-drugs
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
JPH04502317A (ja) * 1988-12-06 1992-04-23 ジ・アップジョン・カンパニー 抗菌性キノロン化合物
WO2004043496A1 (de) * 2002-11-11 2004-05-27 Austria Wirtschaftsservice Gesellschaft M.B.H. Fluor-18-markierte fluorchinolone
WO2010140562A1 (ja) 2009-06-04 2010-12-09 新日本石油株式会社 潤滑油組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) * 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
US3590036A (en) * 1968-11-18 1971-06-29 George Y Lesher Naphthyridine-3-carboxylic acids,their derivatives and preparation thereof
US4017622A (en) * 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
SE444566B (sv) * 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3363711D1 (en) * 1982-03-31 1986-07-03 Sterling Drug Inc New quinolone compounds and preparation thereof
DE3248505A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(4- (oxoalkyl)-1-piperazinyl/-3-chinolincarbonsaeuren und ihre derivate, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306772A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Also Published As

Publication number Publication date
FI83955C (fi) 1991-09-25
DE3461087D1 (en) 1986-12-04
ES8500931A1 (es) 1984-11-01
AU2428384A (en) 1984-08-30
US4559342A (en) 1985-12-17
PT78114A (en) 1984-03-01
NO840557L (no) 1984-08-27
KR870000891B1 (ko) 1987-05-02
IL71036A (en) 1987-12-31
PH22443A (en) 1988-09-12
PT78114B (en) 1986-04-30
DK103284A (da) 1984-08-26
IE56924B1 (en) 1992-01-29
IE840443L (en) 1984-08-25
CA1216849A (en) 1987-01-20
DE3306772A1 (de) 1984-08-30
FI83955B (fi) 1991-06-14
ATE23152T1 (de) 1986-11-15
GR79988B (ko) 1984-10-31
PH21906A (en) 1988-04-08
PH23079A (en) 1989-04-10
DK103284D0 (da) 1984-02-24
JPH0430391B2 (ko) 1992-05-21
FI840747L (fi) 1984-08-26
IL71036A0 (en) 1984-05-31
NZ207238A (en) 1986-05-09
EP0117474A1 (de) 1984-09-05
ES530045A0 (es) 1984-11-01
HU192398B (en) 1987-06-29
EP0117474B1 (de) 1986-10-29
JPS59157068A (ja) 1984-09-06
AU562184B2 (en) 1987-06-04
ZA841375B (en) 1984-10-31
AR244669A1 (es) 1993-11-30
FI840747A0 (fi) 1984-02-23

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