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KR830007549A - 2-옥소아제티딘 유도체의 제법 - Google Patents

2-옥소아제티딘 유도체의 제법 Download PDF

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Publication number
KR830007549A
KR830007549A KR1019810004759A KR810004759A KR830007549A KR 830007549 A KR830007549 A KR 830007549A KR 1019810004759 A KR1019810004759 A KR 1019810004759A KR 810004759 A KR810004759 A KR 810004759A KR 830007549 A KR830007549 A KR 830007549A
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KR
South Korea
Prior art keywords
amino group
acylated
formula
protected
compound
Prior art date
Application number
KR1019810004759A
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English (en)
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KR880001564B1 (ko
Inventor
다이쓰께 마쓰오
히로또모 마스야
노리요시 노꾸찌
미찌히꼬 오찌아이
Original Assignee
구라바야시 이꾸시로
다께다 야꾸힝 고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1980/000296 external-priority patent/WO1982001872A1/ja
Priority claimed from PCT/JP1981/000102 external-priority patent/WO1982003858A1/ja
Priority claimed from PCT/JP1981/000192 external-priority patent/WO1983000690A1/ja
Application filed by 구라바야시 이꾸시로, 다께다 야꾸힝 고오교 가부시끼가이샤 filed Critical 구라바야시 이꾸시로
Publication of KR830007549A publication Critical patent/KR830007549A/ko
Application granted granted Critical
Publication of KR880001564B1 publication Critical patent/KR880001564B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

2-옥소아제티딘 유도체의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기구조식(Ⅱ)의 화합물을 술폰화시키고, 필요에 따라 R2가 보호되는아미노기일 경우의 보호기를 제거시킴을 특징으로 하는 하기구조식(I) 화합물의 제조방법.
    여기서,
    R1은 임의로 아실화되거나, 보호되는 아미노기이고,
    X는 수소 또는 메톡시기이며,
    R4는 아지도, 할로겐, 임의로 아실화되는 아미노기, 또는 OR5,또는 --S-S-R5기이다.
    (여기서, R5는 유기잔기이고, n는 0,1 또는 2이다)
    여기서, R2는 아실화 또는 보호되는 아미노기이고, X 및 R4는 상기에서 정의한 바와 같다.
  2. 제1항에 있어서, 출발물질을 실질화시킴을 특징으로 하는방법.
  3. 하기식(IV)의 화합물을 아실화시킴을 특징으로 하는 하기식(III) 화합물의 제조방법.
    여기서, R3는 아실화되는 아미노기이고,
    X는 수소 또는 메톡시이고,
    R4는 아지도, 할로겐, 임의로 아실화되는 또는 -OR5,또는 S-S-R5기이다
    (여기서, R5는 유기잔기이고, n는 0,1 또는 2임).
    여기서, X 및 R4는 상기와 동일한 의미를 갖는다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810004759A 1980-12-05 1981-12-05 2-옥소아제티딘 유도체의 제법 KR880001564B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PCT/JP1980/000296 WO1982001872A1 (en) 1980-12-05 1980-12-05 Azetidine derivatives and process for their preparation
JPPCT/JP80/00296 1980-12-05
PCT/JP1981/000102 WO1982003858A1 (fr) 1981-04-30 1981-04-30 Derives d'azetidine et procede de preparation
JPPCT/JP81/00192 1981-04-30
JPPCT/JP81/00102 1981-04-30
PCT/JP1981/000192 WO1983000690A1 (en) 1981-08-25 1981-08-25 Azetidine derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
KR830007549A true KR830007549A (ko) 1983-10-21
KR880001564B1 KR880001564B1 (ko) 1988-08-22

Family

ID=27303167

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004759A KR880001564B1 (ko) 1980-12-05 1981-12-05 2-옥소아제티딘 유도체의 제법

Country Status (26)

Country Link
US (1) US4822790A (ko)
EP (1) EP0053815B1 (ko)
JP (1) JPS57131759A (ko)
KR (1) KR880001564B1 (ko)
AT (3) ATE13178T1 (ko)
AU (1) AU551463B2 (ko)
CH (1) CH656122A5 (ko)
DE (2) DE3148020A1 (ko)
DK (1) DK534381A (ko)
ES (2) ES507716A0 (ko)
FI (1) FI79528C (ko)
FR (1) FR2495612A1 (ko)
GB (1) GB2091723B (ko)
HU (1) HU189545B (ko)
IE (1) IE53451B1 (ko)
IL (1) IL64314A (ko)
IT (1) IT1146726B (ko)
LU (1) LU83820A1 (ko)
MX (1) MX7096E (ko)
NL (1) NL8105468A (ko)
NO (1) NO160297C (ko)
NZ (1) NZ199168A (ko)
PT (1) PT74087B (ko)
SE (1) SE8107273L (ko)
SU (2) SU1662348A3 (ko)
WO (1) WO1982002042A1 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU557649B2 (en) * 1981-03-30 1987-01-08 E.R. Squibb & Sons, Inc. 4-substituted mercapto-2-oxo-1-azetidinesulfonic acid salts
US4734496A (en) * 1981-05-29 1988-03-29 E. R. Squibb & Sons, Inc. 4-amino derivatives of 2-oxo-1-azetidinesulfonic acid salts
JPS588060A (ja) * 1981-06-29 1983-01-18 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド アリ−ルチオアゼチジノンスルホン酸塩類
FR2509726B1 (ko) * 1981-07-16 1984-04-27 Squibb & Sons Inc
ATE24726T1 (de) * 1981-10-05 1987-01-15 Squibb & Sons Inc 4-aether-derivate von 2-azetidinon-1-sulfonsaeuren.
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
JPS58210060A (ja) * 1982-05-31 1983-12-07 Takeda Chem Ind Ltd ２−オキソアゼチジン誘導体、その製造法および用途
JPS5916888A (ja) * 1982-07-20 1984-01-28 Takeda Chem Ind Ltd １−スルホ−２−アゼチジノン誘導体およびその製造法
US4681937A (en) * 1982-09-27 1987-07-21 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters
JPS59101485A (ja) * 1982-11-29 1984-06-12 Otsuka Chem Co Ltd アセチジノン誘導体
DE3342929A1 (de) * 1983-11-26 1985-06-05 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel
US4883869A (en) * 1984-12-20 1989-11-28 The Upjohn Company Novel beta-lactams containing amino acid substituents
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
KR890700586A (ko) * 1987-02-27 1989-04-25 로버어트 에이 아마테이지 피리돈 카르복실산 또는 산유도체를 함유하는 항균제 베타-락탐
CA1317298C (en) * 1987-03-03 1993-05-04 Upjohn Company (The) Antibiotic sulfonylaminocarbonyl activated .beta.-lactams
US5015737A (en) * 1987-07-22 1991-05-14 The Upjohn Company Therapeutically useful beta-lactams
EP0950046B1 (en) * 1996-09-23 2002-04-10 Naeja Pharmaceutical Inc. 3,4-disubstituted azetidin-2-one derivatives useful as cysteine proteinase regulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6046955B2 (ja) * 1977-12-30 1985-10-18 武田薬品工業株式会社 抗生物質ｇ−６３０２
JPS5549394A (en) * 1978-10-03 1980-04-09 Takeda Chem Ind Ltd Antibiotic substance sb-72310
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
CA1338538C (en) * 1979-06-08 1996-08-20 Taisuke Matsuo 1-sulfo-2-oxoazetidine derivatives and their production
EP0021676B1 (en) * 1979-06-08 1983-09-14 Takeda Chemical Industries, Ltd. 3-methoxy-2-oxoazetidine derivatives and their production
NZ205240A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
AU557649B2 (en) * 1981-03-30 1987-01-08 E.R. Squibb & Sons, Inc. 4-substituted mercapto-2-oxo-1-azetidinesulfonic acid salts
JPS588060A (ja) * 1981-06-29 1983-01-18 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド アリ−ルチオアゼチジノンスルホン酸塩類
FR2509726B1 (ko) * 1981-07-16 1984-04-27 Squibb & Sons Inc
FR2515182B1 (fr) * 1981-10-23 1986-05-09 Roussel Uclaf Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation

Also Published As

Publication number Publication date
PT74087B (en) 1983-05-23
DK534381A (da) 1982-06-06
CH656122A5 (de) 1986-06-13
LU83820A1 (fr) 1982-05-07
ES8305325A1 (es) 1983-04-01
PT74087A (en) 1982-01-01
US4822790A (en) 1989-04-18
NO814113L (no) 1982-06-07
FI79528B (fi) 1989-09-29
IT1146726B (it) 1986-11-19
IE53451B1 (en) 1988-11-23
GB2091723A (en) 1982-08-04
JPS57131759A (en) 1982-08-14
EP0053815B1 (en) 1985-05-08
MX7096E (es) 1987-06-19
IT8168585A0 (it) 1981-12-04
ES513420A0 (es) 1983-04-01
GB2091723B (en) 1985-06-12
AU7831381A (en) 1982-06-10
SU1531852A3 (ru) 1989-12-23
FR2495612B1 (ko) 1984-06-01
ES8301915A1 (es) 1982-12-16
WO1982002042A1 (en) 1982-06-24
ATA170384A (de) 1985-10-15
AT380471B (de) 1986-05-26
FR2495612A1 (fr) 1982-06-11
SU1662348A3 (ru) 1991-07-07
DE3148020A1 (de) 1982-10-21
ATA520781A (de) 1985-07-15
DE3170437D1 (en) 1985-06-13
NZ199168A (en) 1985-08-30
IL64314A (en) 1988-06-30
EP0053815A1 (en) 1982-06-16
ATE13178T1 (de) 1985-05-15
HU189545B (en) 1986-07-28
AU551463B2 (en) 1986-05-01
FI813851L (fi) 1982-06-06
AT379800B (de) 1986-02-25
KR880001564B1 (ko) 1988-08-22
IL64314A0 (en) 1982-02-28
SE8107273L (sv) 1982-06-06
NO160297B (no) 1988-12-27
NO160297C (no) 1989-04-05
IE812859L (en) 1982-06-05
ES507716A0 (es) 1982-12-16
NL8105468A (nl) 1982-07-01
FI79528C (fi) 1990-01-10

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