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KR830006430A - 탈(마이시노실옥시)타일로신의 제조방법 - Google Patents

탈(마이시노실옥시)타일로신의 제조방법 Download PDF

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Publication number
KR830006430A
KR830006430A KR1019810002108A KR810002108A KR830006430A KR 830006430 A KR830006430 A KR 830006430A KR 1019810002108 A KR1019810002108 A KR 1019810002108A KR 810002108 A KR810002108 A KR 810002108A KR 830006430 A KR830006430 A KR 830006430A
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KR
South Korea
Prior art keywords
tyrosine
preparing
mycinosiloxy
mycinosyloxy
mycinoyloxy
Prior art date
Application number
KR1019810002108A
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English (en)
Other versions
KR840001957B1 (ko
Inventor
헨리 발츠 리차드
뮤리엘 와일드 진
토마스 세노 유진
앤드류 커스트 허버트
Original Assignee
아더 알. 웨일
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/156,855 external-priority patent/US4321362A/en
Application filed by 아더 알. 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR830006430A publication Critical patent/KR830006430A/ko
Application granted granted Critical
Publication of KR840001957B1 publication Critical patent/KR840001957B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Processing Of Solid Wastes (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

내용 없음

Description

탈(마이시노실옥시)타일로신의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
도면은 클로로포름중에서 DMOT(유리염기)의 적외부 흡수 스펙트럼

Claims (3)

  1. 스트렙토마이세스 프라디아에 NRRL 12171을 심부호기성 조건하 상당수준의 항생물질 활성이 생성될 때까지 배양시켜서 마크롤라이드를 수득하거나 23-탈(마이시노실옥시) 타일로신을 화학적 환원제로 환원시켜 Q가 -CH2OH인 마크롤라이드를 형성하고 필요하다면 염화 또는 에스테르화하여 염 또는 에스테르를 형성시킴을 특징으로 하여 다음 일반식(Ⅰ)의 마크룰라이드 그의 약학적으로 무독한 염, 또는 아실에스테르를 제조하는 방법.
    상기식에서
    Q는 -CH2OH 또는 -CHO 이다.
  2. 23-탈(마이시노일옥시) 타일로신을 제조하는 특허청구 범위 1에 따르는 방법.
  3. 20-디하이드로-23-탈(마이시노실옥시) 타일로신을 제조하는 특허청구범위 1에 따르는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810002108A 1980-06-12 1981-06-12 데(마이시노실옥시)타일로신의 제조방법 KR840001957B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/156,855 US4321362A (en) 1980-06-12 1980-06-12 De(mycinosyloxy)tylosin and process for its production
US156855 1980-06-12

Publications (2)

Publication Number Publication Date
KR830006430A true KR830006430A (ko) 1983-09-24
KR840001957B1 KR840001957B1 (ko) 1984-10-26

Family

ID=22561375

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810002108A KR840001957B1 (ko) 1980-06-12 1981-06-12 데(마이시노실옥시)타일로신의 제조방법

Country Status (24)

Country Link
EP (1) EP0042694B1 (ko)
JP (1) JPS5731698A (ko)
KR (1) KR840001957B1 (ko)
AT (1) ATE6468T1 (ko)
AU (1) AU544358B2 (ko)
CA (1) CA1172190A (ko)
CS (1) CS225842B2 (ko)
DD (1) DD159645A5 (ko)
DE (1) DE3162501D1 (ko)
DK (1) DK255581A (ko)
ES (1) ES8203963A1 (ko)
FI (1) FI811827L (ko)
GB (1) GB2077730B (ko)
GR (1) GR75276B (ko)
HU (1) HU189979B (ko)
IE (1) IE51613B1 (ko)
IL (1) IL63076A (ko)
NZ (1) NZ197360A (ko)
PH (1) PH15924A (ko)
PT (1) PT73164B (ko)
RO (1) RO81017A (ko)
SU (1) SU1134120A3 (ko)
YU (1) YU144281A (ko)
ZA (1) ZA813578B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423148A (en) * 1982-07-02 1983-12-27 Eli Lilly And Company Process for producing 20-dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US4435388A (en) 1982-06-10 1984-03-06 Schering Corporation Tylosin 20-imino-20-deoxo-4"-acyl derivatives, pharmaceutical compositions and method of use
JPS58219197A (ja) * 1982-06-15 1983-12-20 Sanraku Inc マクロライド系抗生物質の誘導体
US4436729A (en) * 1982-06-30 1984-03-13 Schering Corporation 23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use
US4452784A (en) * 1982-07-19 1984-06-05 Eli Lilly And Company C-23-Modified derivatives of DMT
IL71032A0 (en) * 1983-02-28 1984-05-31 Lilly Co Eli C-20 and c-23-modified macrolide derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1428452A (fr) * 1958-10-29 1966-02-18 Lilly Co Eli Méthodes de production de nouveaux composés organiques azotés, tels que la tylosine et la desmycosine
US4161523A (en) * 1972-11-15 1979-07-17 Schering Corporation Rosamicin esters, acid addition salts and methods for production thereof

Also Published As

Publication number Publication date
PT73164A (en) 1981-07-01
KR840001957B1 (ko) 1984-10-26
YU144281A (en) 1983-09-30
AU544358B2 (en) 1985-05-23
DD159645A5 (de) 1983-03-23
CS225842B2 (en) 1984-02-13
EP0042694A1 (en) 1981-12-30
GB2077730B (en) 1984-06-20
EP0042694B1 (en) 1984-03-07
IL63076A0 (en) 1981-09-13
ATE6468T1 (de) 1984-03-15
GR75276B (ko) 1984-07-13
PT73164B (en) 1982-07-16
ES502981A0 (es) 1982-04-16
HU189979B (en) 1986-08-28
SU1134120A3 (ru) 1985-01-07
AU7144781A (en) 1981-12-17
ES8203963A1 (es) 1982-04-16
NZ197360A (en) 1984-03-30
JPS5731698A (en) 1982-02-20
FI811827L (fi) 1981-12-13
RO81017A (ro) 1983-02-01
IE51613B1 (en) 1987-01-21
PH15924A (en) 1983-04-26
ZA813578B (en) 1983-01-26
GB2077730A (en) 1981-12-23
DE3162501D1 (en) 1984-04-12
DK255581A (da) 1981-12-13
CA1172190A (en) 1984-08-07
IE811296L (en) 1981-12-12
IL63076A (en) 1984-07-31

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