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KR830000680A - N-알킬화 아미노알콜의 제조방법 - Google Patents

N-알킬화 아미노알콜의 제조방법 Download PDF

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Publication number
KR830000680A
KR830000680A KR1019820001067A KR820001067A KR830000680A KR 830000680 A KR830000680 A KR 830000680A KR 1019820001067 A KR1019820001067 A KR 1019820001067A KR 820001067 A KR820001067 A KR 820001067A KR 830000680 A KR830000680 A KR 830000680A
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KR
South Korea
Prior art keywords
group
alk
general formula
substituted
producing
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Ceased
Application number
KR1019820001067A
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English (en)
Inventor
오스터마이어 푸란쯔
찌머만 다르쿠스
Original Assignee
아놀드 자인러 에른스트 알테르
시바 가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 아놀드 자인러 에른스트 알테르, 시바 가이기 에이지 filed Critical 아놀드 자인러 에른스트 알테르
Publication of KR830000680A publication Critical patent/KR830000680A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

내용 없음

Description

N-알킬화 아미노알콜의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(V)의 화합물을 수소화시킴을 특징으로 하는 일반식(I)의 N-알킬화 아미노알콜 및 그의 염을 제조하는 방법.
    상기식에서
    Ar은 치환되지 않거나 하이드록실로 치환된 방향족기이고,
    n은 0 또는 1이며,
    Alk는 탄소수 2 내지 5개의 알킬렌기이며,
    질소원자는 산소원자 또는 n이 0인 경우에는 페닐기와 적어도 2개의 탄소원자에 의해 서로 분리되어 있고,
    X6는 일반식 -CH=N-Alk-(Va), -CH2-N=Alk1, (Vb), -C(=X7)-N(X8)-Alk-(Vc), -CH2-N(X8)-C(=X7)-Alk2-(Vd) 또는 -CH2-N(X8)-Alk-(Ve)의 환원성 그룹이며,
    Alk1은 Alk기에 상응하는 알킬-일리덴기이고,
    Alk2는 질소원자에 결합된 메틸렌기에 의해 단축된(즉 탄소수가 1개 적은) Alk기에 상응하는 기,
    X7은 옥소와 티오옥소기,
    X8은 수소 또는 X6및/또는 Y를 환원시키는 조건하에서 수소로 치환될 수 있는 기이고,
    Y는 일반식 -CO-(Vf) 또는 -CH(OX8)-(Vg)기 (이때 X8은 전술된 바와 같음)이고,
    Ar2는 Ar기에 상응하지만 한개나 두개의 하이드록실기 대신에 한개나 두개의 OX8그룹(이때 X8은 전술된 바와 같음)을 수반할 수 있다.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019820001067A 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법 Ceased KR830000680A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH6136/78-4? 1978-06-05
CH613678 1978-06-05

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR7901814A Division KR840000926B1 (ko) 1978-06-05 1979-06-04 N-알킬화된 아미노알콜의 제조방법

Publications (1)

Publication Number Publication Date
KR830000680A true KR830000680A (ko) 1983-04-18

Family

ID=4304840

Family Applications (4)

Application Number Title Priority Date Filing Date
KR7901814A Expired KR840000926B1 (ko) 1978-06-05 1979-06-04 N-알킬화된 아미노알콜의 제조방법
KR1019820001068A Ceased KR830000681A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법
KR1019820001067A Ceased KR830000680A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법
KR1019820001066A Ceased KR830000679A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법

Family Applications Before (2)

Application Number Title Priority Date Filing Date
KR7901814A Expired KR840000926B1 (ko) 1978-06-05 1979-06-04 N-알킬화된 아미노알콜의 제조방법
KR1019820001068A Ceased KR830000681A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019820001066A Ceased KR830000679A (ko) 1978-06-05 1982-03-12 N-알킬화 아미노알콜의 제조방법

Country Status (25)

Country Link
US (1) US4460580A (ko)
EP (1) EP0005848B1 (ko)
JP (1) JPS54163543A (ko)
KR (4) KR840000926B1 (ko)
AR (3) AR229022A1 (ko)
AT (1) ATE511T1 (ko)
AU (1) AU522483B2 (ko)
CA (1) CA1124241A (ko)
CY (1) CY1256A (ko)
DD (1) DD144050A5 (ko)
DE (1) DE2961669D1 (ko)
DK (1) DK229879A (ko)
ES (1) ES481238A1 (ko)
GB (1) GB2026474B (ko)
GR (1) GR74057B (ko)
HK (1) HK15585A (ko)
HU (1) HU182019B (ko)
IL (1) IL57471A (ko)
MY (1) MY8500690A (ko)
NO (1) NO149034C (ko)
NZ (1) NZ190632A (ko)
PL (5) PL117155B1 (ko)
PT (1) PT69723A (ko)
SG (1) SG45884G (ko)
ZA (1) ZA792748B (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100380520B1 (ko) * 2000-09-08 2003-04-23 한국화학연구원 피리딘을 포함한 β-아미노알코올 유도체
CN104008939A (zh) * 2014-06-19 2014-08-27 苏州普京真空技术有限公司 一种耐用电子枪灯丝

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AU1533495A (en) * 1994-01-12 1995-08-01 Byk Nederland Bv Phenyl ethanol amine ethers and uses thereof as beta-adreno-receptor agonists
DE69533948T2 (de) 1994-10-21 2005-12-15 NPS Pharmaceuticals, Inc., Salt Lake City Kalzium-Rezeptor aktive Verbindungen
PT907631E (pt) 1996-05-01 2003-10-31 Nps Pharma Inc Compostos inorganicos activos como receptores de ioes
US20050151459A1 (en) * 2002-04-22 2005-07-14 Geerdinck Leonie M. Luminescent screen
US7538141B2 (en) * 2004-03-23 2009-05-26 Alan Daniel Brown Compounds for the treatment of diseases
JP2013522195A (ja) * 2010-03-08 2013-06-13 ザ ユニバーシティー オブ テネシー リサーチ ファウンデーション ベータアドレナリン受容体アゴニスト及びその使用
ITMI20122221A1 (it) * 2012-12-21 2014-06-22 C4T S C A R L Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100380520B1 (ko) * 2000-09-08 2003-04-23 한국화학연구원 피리딘을 포함한 β-아미노알코올 유도체
CN104008939A (zh) * 2014-06-19 2014-08-27 苏州普京真空技术有限公司 一种耐用电子枪灯丝
CN104008939B (zh) * 2014-06-19 2016-05-11 苏州普京真空技术有限公司 一种耐用电子枪灯丝

Also Published As

Publication number Publication date
PL116612B1 (en) 1981-06-30
PL216090A1 (ko) 1980-03-24
DE2961669D1 (en) 1982-02-18
AR229951A1 (es) 1984-01-31
PT69723A (de) 1979-07-01
AR229022A1 (es) 1983-05-31
AU4773679A (en) 1979-12-13
PL117155B1 (en) 1981-07-31
NO149034B (no) 1983-10-24
KR840000926B1 (ko) 1984-06-29
DD144050A5 (de) 1980-09-24
AR229581A1 (es) 1983-09-30
ATE511T1 (de) 1982-01-15
ZA792748B (en) 1980-06-25
KR830000681A (ko) 1983-04-18
CY1256A (en) 1984-11-23
DK229879A (da) 1979-12-06
JPS54163543A (en) 1979-12-26
HU182019B (en) 1983-12-28
SG45884G (en) 1985-03-08
CA1124241A (en) 1982-05-25
MY8500690A (en) 1985-12-31
EP0005848B1 (de) 1981-12-30
KR830000679A (ko) 1983-04-18
PL117158B1 (en) 1981-07-31
ES481238A1 (es) 1980-02-16
NZ190632A (en) 1984-07-06
GR74057B (ko) 1984-06-06
NO791841L (no) 1979-12-06
GB2026474A (en) 1980-02-06
AU522483B2 (en) 1982-06-10
IL57471A (en) 1982-11-30
HK15585A (en) 1985-03-15
NO149034C (no) 1984-02-01
PL116597B1 (en) 1981-06-30
PL116529B1 (en) 1981-06-30
EP0005848A1 (de) 1979-12-12
US4460580A (en) 1984-07-17
GB2026474B (en) 1982-07-14

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