KR20240104964A - A cosmetic composition containing a mixed extract as an active ingredient and having an effect of improving skin inflammation - Google Patents

Abstract

The present invention relates to a cosmetic composition effective in improving skin inflammation that contains, as an active ingredient, a CSP mixed extract with an anti-inflammatory effect, including a CSP mixed extract obtained by extracting a mixture of health, dandruff, and root stems.

Description

Cosmetic composition effective in improving skin inflammation containing CSP {A cosmetic composition containing a mixed extract as an active ingredient and having an effect of improving skin inflammation}

The present invention relates to a cosmetic composition, and more specifically, to a cosmetic composition effective in improving skin inflammation containing CSP, which has an anti-inflammatory effect, including a mixed extract obtained by extracting a mixture of health, dandelion, and root stems. .

Cosmetics are products used to protect the skin and beautify and cleanse, but if you look at cosmetic compositions, ingredients different from those for skin protection are used as essential elements in the formation of the product. For example, surfactants, preservatives, fragrances, sunscreens, pigments, and various other ingredients used to provide efficacy and effects. These ingredients are generally known to cause various side effects such as skin inflammation, rashes, and swelling. In addition, sebum, sweat, and fatty acids, higher alcohols, and proteins in cosmetic ingredients that are discharged from the body may be decomposed into highly toxic substances by skin flora existing on the skin, which may cause skin inflammation. It is known that skin inflammation is also caused by ultraviolet rays from the sun.

Inflammation is the body's immune response to wounds or diseases, and oxidative stress such as ultraviolet rays, active oxygen, and free radicals activate inflammatory factors, causing various diseases and skin aging. One of the hallmarks of inflammation is arachidonic acid, which is metabolized by the cyclooxygenase (COX) pathway, which produces prostaglandins, and the 5-lipoxygenase pathway, which produces leukotrienes. ) is an increase in the oxygen addition reaction. Prostaglandins and leukotrienes are mediators of inflammation. Therefore, treatments designed to inhibit COX and/or lipoxygenase activity are of great interest. COX has two forms: COX-1 and COX-2. Among these, COX-2 appears to play an important role in the progression of inflammation. Therefore, inhibiting COX-2 may be an effective way to reduce inflammation without the side effects associated with irreversible COX-1 inhibition.

Nitric Oxide synthase (NOS), an enzyme that generates Nitric Oxide (NO), another powerful inflammatory mediator, and enzymes related to the biosynthesis of prostaglandins play an important role in mediating the inflammatory response. It is known that it is being done. Therefore, NOS, an enzyme that generates NO from L-arginine, and COX, an enzyme involved in synthesizing prostaglandins from arachidonic acid, are the main targets in blocking inflammation. According to recent research results, there are several types of NOS, including bNOS (brain NOS) in the brain, nNOS (neuronal NOS) in the nervous system, and eNOS (endothelial NOS) in the vascular system. The NO produced in small amounts plays an important role in maintaining normal body homeostasis by inducing nerve transmission and vasodilation, while iNOS is induced by various cytokines or external irritants. NO, which is rapidly generated in excessive amounts by (inducible NOS), is known to cause cytotoxicity and various inflammatory reactions, and studies have shown that chronic inflammation is associated with an increase in iNOS activity.

To date, substances used to relieve irritation such as erythema or edema and relieve inflammation include non-steroidal substances such as flufenamic acid, ibuprofen, benzydamine, and indomethacin. There are steroids such as prednisolone and dexamethasone [Chang-jong Kim, Pathophysiology, Hallym Corporation, pp. 61-69, 1988], allantoin, azrene, ε-amino caproic acid, hydrocortisone, licorice acid and its derivatives (β-glycyrrhizinic acid, glycyrrhizate) It is known to have anti-inflammatory effects.

As such, factors that cause skin side effects are always potential in cosmetics, and various studies have been conducted to solve this problem. However, indomethacin, which is used as an anti-inflammatory agent, cannot be used in cosmetics, hydrocortisone has a limited amount of use, and licorice Acids and their derivatives are difficult to stabilize or have poor solubility, making it difficult to achieve practical effects due to concentration limits when applied in practice. Most of the anti-inflammatory agents known so far have problems in terms of skin safety and stability when mixing cosmetics. Therefore, its use is restricted. In particular, recently, research and development on cosmetics using natural raw materials has been actively conducted to meet the needs of consumers.

Accordingly, the need for anti-inflammatory cosmetic compositions using natural products is emerging, avoiding the problems of chemical substances, and the need for cosmetic compositions with remarkable anti-inflammatory effects is increasing.

Republic of Korea Patent Publication No. 10-2013-0138590 (published on December 19, 2013), “Anti-inflammatory pharmaceutical composition and cosmetic composition containing alloferon”

In order to solve the above problems, the present invention aims to provide a cosmetic composition effective in improving skin inflammation containing CSP, which has an anti-inflammatory effect, including a mixed extract obtained by extracting a mixture of health, diced, and root stems. There is.

In order to achieve the above object, the present invention provides a cosmetic composition containing a mixed extract of health, diced horn, and eureum stem, characterized in that it contains a mixed extract obtained by extracting a mixture of cheonghwa, gonakak, and eureum stem. do.

In addition, the mixture is characterized in that it contains healthy, goekak, and eoreumstem in a weight ratio of 0.5 ~ 10.0: 0.5 ~ 10.0: 0.5 ~ 10.0, respectively.

In addition, the mixed extract is characterized in that it is extracted with any one extraction solvent selected from the group consisting of purified water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butylacetate, and 1,3-butylene glycol. Do it as

In addition, it is characterized by containing the above mixed extract as an active ingredient and having an anti-inflammatory effect.

In addition, the present invention contains the above mixed extract as an active ingredient, and is used in lotion, skin, lotion, cream, foundation, essence, gel, pack, emulsified sunscreen cream, emulsified foundation, emulsified makeup base, and oil cake type. Provided is a cosmetic composition that is manufactured in the form of a foundation, two-way cake, or powder pact.

The cosmetic composition containing CSP according to the present invention, which is effective in improving skin inflammation, has an anti-inflammatory effect, including a CSP mixed extract obtained by extracting a mixture of health, dandelion, and root stems.

1 is a graph showing cytotoxicity experiments for Example 1 and Comparative Examples 1 to 3 of the present invention.
Figure 2 is a graph showing NO production inhibition experiments for Example 1 and Comparative Examples 1 to 3 of the present invention.
Figure 3 is a graph showing the TNF-α inhibition experiment for Example 1 and Comparative Examples 1 to 3 of the present invention.

The following detailed description of the present invention is an embodiment in which the present invention can be practiced and refers to the accompanying drawings, which are shown as examples of the corresponding embodiments. These embodiments are described in sufficient detail to enable any person skilled in the art to practice the invention. It should be understood that the various embodiments of the invention are different from one another but are not necessarily mutually exclusive. For example, specific shapes, structures and characteristics described herein with respect to one embodiment may be implemented in other embodiments without departing from the spirit and scope of the invention. Additionally, it should be understood that the location or arrangement of individual components within each described embodiment may be changed without departing from the spirit and scope of the invention.

Accordingly, the detailed description set forth below is not intended to be taken in a limiting sense, and the scope of the present invention is limited only by the appended claims together with all equivalents to what those claims would assert if properly described. Similar reference numbers in the drawings refer to identical or similar functions across various aspects.

The terms used in the present invention are general terms that are currently widely used as much as possible while considering the functions in the present invention, but this may vary depending on the intention or precedent of a person working in the art, the emergence of new technology, etc. In addition, in certain cases, there are terms arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the description of the relevant invention. Therefore, the terms used in the present invention should be defined based on the meaning of the term and the overall content of the present invention, rather than simply the name of the term.

In the present invention, when a part “includes” a certain component, this means that, unless specifically stated to the contrary, it does not exclude other components but may further include other components.

Hereinafter, a cosmetic composition effective in improving skin inflammation containing CSP according to the present invention and its manufacturing method will be described in detail.

The cosmetic composition according to the present invention is characterized in that it contains a CSP mixed extract of Health, Gyeokak, and Eureum stem.

In the present invention, the CSP mixed extract is a term arbitrarily designated by the applicant, and refers to an extract extracted by mixing health, snail, and root stems (abbreviated as CSP).

The above health is ginger ( Zingiber officinale Roscoe ) refers to a herbal medicine made by drying the rhizome part. This medicine has a unique odor and its properties are spicy and hot. [辛熱] The above health medicine has the effect of warming the spleen and stomach, eliminating cold, regenerating yang, and making the blood flow through the veins, and it causes vomiting. It treats symptoms such as diarrhea, cold limbs and weak pulse, shortness of breath and coughing when eating cold food, and vomiting and bleeding due to yang deficiency. It's medicine. In the present invention, it is preferable to use the dried rhizome of ginger, not the stem or leaf part, for the above-mentioned health.

The above-mentioned square is a locust tree ( Sophora) japonica ) refers to the fruit. The above is a medicinal herb that is effective in reducing fever, moistening the dry liver, cooling the blood, and stopping bleeding. In the present invention, the ingots are the fruit of the prickly pear tree, and it is preferable to use the fruit parts rather than the stem, roots, and leaves of the prickly pear tree.

The above-mentioned stems are Akebia quinata ) refers to the stem part. In the present invention, it is preferable to use the stem part of Akebia quinata rather than the fruit or root. The creeping vine has five leaflets attached to long petioles and spreads out in a long form. Dark purple flowers bloom in spring, and long, oval-shaped berries ripen in dark purple in fall.

The composition according to the present invention preferably contains a CSP mixed extract obtained by extracting a mixture of health, snail, and root stems in a weight ratio of 0.5 ~ 10.0: 0.5 ~ 10.0: 0.5 ~ 10.0 using an extraction solvent, and in a more specific weight ratio. It would be preferable to extract it by mixing healthy, diced, and eureum stems at a weight ratio of 2.9:3.9:3.2. Meanwhile, the weight ratio of 2.9:3.9:3.2 is based on the raw material, and the weight ratio may be 5:3:2 based on the concentrate.

At this time, the mixture of healthy, diced, and root stems is an extraction solvent selected from the group consisting of purified water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butylacetate, and 1,3-butylene glycol. It is appropriate to extract using , and most specifically, it would be preferable to extract using ethanol.

In addition, the composition according to the present invention is preferably extracted at 50 to 100 ° C. for 2 to 10 hours when extracting a mixture of dangan, dangan, and euerum stem with an extraction solvent. More specifically, it would be most preferable to mix a mixture of dried, dried, and dried stems with an extraction solvent and extract at 70°C for 6 hours.

On the other hand, the composition according to the present invention is preferably made by extracting a mixture of jeongan, gokgak, and eureum stem with an extraction solvent, cooling to room temperature, and concentrating under reduced pressure.

In summary, the composition according to the present invention is a mixture of health, cut and root stems in a weight ratio of 0.5 ~ 10.0: 0.5 ~ 10.0: 0.5 ~ 10.0, mixed with purified water, anhydrous or hydrous lower alcohol with 1 to 4 carbon atoms, acetone, and ethyl. It may be extracted at 50 to 100°C for 2 to 10 hours using any extraction solvent selected from the group consisting of acetate, butylacetate and 1,3-butylene glycol, cooled to room temperature, and concentrated under reduced pressure.

Most appropriately, it may be obtained by mixing a mixture of health, snail, and root stems at a weight ratio of 2.9:3.9:3.2, extracting the mixture at 70°C for 6 hours using 50% ethanol, cooling to room temperature, and concentrating under reduced pressure. The CSP mixed extract may be extracted under the above conditions, concentrated under reduced pressure, and further aged for 1 to 10 days at room temperature of 15 to 35°C.

In addition to the CSP mixed extract according to the present invention, the present invention includes ingredients commonly used in cosmetic compositions, such as antioxidants, stabilizers, solubilizers, vitamins, pigments, pigments, and flavoring agents, and carriers. do.

The cosmetic composition of the present invention can be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing agents. , oil, powder foundation, emulsion foundation, wax foundation, spray, etc., but is not limited thereto. More specifically, it can be manufactured in the form of softening lotion, nourishing lotion, nourishing cream, massage cream, essence, pack, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray, or powder.

When the formulation of the present invention is a paste, cream or gel, the carrier ingredient may contain one or more of animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide. It can be used by selecting .

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder can be used as the carrier ingredient. In particular, when the formulation is a spray, chlorofluorohydrocarbon and propane may be used as carrier ingredients. /May contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent, or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, butyl. Len glycol, 1,3-butyl glycol oil, polyoxyethylene hydrogenated castor oil, glycerol, glycerin, aliphatic ester, phenoxyethanol, triethanolamine, polyethylene glycol, beeswax, polysorbate 60, sorbitan sesquiolade, paraffin, Sorbitan stearate, lipophilic monostearate glycerin, stearic acid, glyceryl stearate/PEG-400 stearate, carboxypolymer, sitosterol, polyglyceryl 2-oleate, ceramide, cholesterol, steareth-4, dicetyl phosphate. , macadamia oil, carboxyvinyl polymer, xanthan gum, or fatty acid ester of sorbitan can be selected and used.

When the formulation of the present invention is a suspension, the carrier ingredients include water, liquid diluents such as ethanol, glycerin, butylene glycol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester. Same suspending agent, microcrystalline cellulose, hydroxyethylcellulose, sodium hyaluronate, phenoxyethanol, aluminum metahydroxide, bentonite, stearic acid, cetyl alcohol, glyceryl monostearate, polyoxyethylene sorbitan monostearate. , sorbitan sesquioleate, glyceryl monostearate/glyceryl stearate/polyoxyethylene stearate, wax, paripin, squalane, caprylic/capric triglyceride, carboxyvinyl polymer, triethanolamine, agar or triglyceride. It can be used by selecting any one or more of Kant.

When the formulation of the present invention is a surfactant-containing cleansing agent, the carrier ingredients include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, and fatty acid amide. Any one or more of ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester may be selected and used.

In addition, the efficacy of the cosmetic composition according to an embodiment of the present invention can be appropriately adjusted depending on the individual's skin condition and condition, and external environmental conditions.

Hereinafter, a method for producing a cosmetic composition effective in improving skin inflammation containing CSP according to the present invention will be described in detail.

The method for producing a cosmetic composition effective in improving skin inflammation containing CSP according to the present invention includes a mixture preparation step (S10) of preparing a mixture by mixing health, snails, and euerum stems; The mixture prepared in the mixture preparation step (S10) is extracted with any one selected from the group consisting of purified water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butylacetate, and 1,3-butylene glycol. Extraction step (S20) of extracting the CSP mixed extract by mixing with a solvent; And, it includes a reduced pressure concentration step (S30) in which the CSP mixed extract of the extraction step (S20) is cooled and concentrated under reduced pressure.

First, the mixture preparation step (S10) is performed.

In the mixture preparation step (S10), a mixture is prepared by mixing health, goekak, and eoreumstem.

The mixture in the mixture preparation step (S10) is preferably a mixture of health, goekak, and eoreumstem at a weight ratio of 0.5 to 10.0:0.5 to 10.0:0.5 to 10.0, respectively.

More specifically, the mixture in the mixture preparation step (S10) is preferably a mixture of health, goekak, and eoreumstem at a weight ratio of 2.9:3.9:3.2, respectively.

Next, an extraction step (S20) is performed.

In the extraction step (S20), the mixture prepared in the mixture preparation step (S10) is a group consisting of purified water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butylacetate, and 1,3-butylene glycol. A CSP mixed extract is prepared by extraction with any one of the extraction solvents selected from.

In the extraction step (S20), the mixture prepared in the mixture preparation step (S10) is a group consisting of purified water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butylacetate, and 1,3-butylene glycol. Extract at 50 to 100°C for 2 to 10 hours using any extraction solvent selected from.

More specifically, in the extraction step (S20), it is preferable to extract the mixture prepared in the mixture preparation step (S10) using 50% ethanol at 70°C for 6 hours.

Next, a reduced pressure concentration step (S30) is performed.

In the reduced pressure concentration step (S30), the CSP mixed extract of the extraction step (S20) is cooled and concentrated under reduced pressure.

More specifically, in the reduced pressure concentration step (S30), it is preferable that the CSP mixed extract of the extraction step (S20) is cooled to room temperature of 15 to 35°C and concentrated under reduced pressure.

Additionally, the method for producing a cosmetic composition effective in improving skin inflammation containing CSP according to the present invention may further include a maturing step (S35). In the ripening step (S35), the CSP mixed extract that has gone through the reduced pressure concentration step (S30) may be further aged at room temperature of 15 to 35°C for 1 to 10 days.

Hereinafter, the effects of the cosmetic composition according to the present invention will be described in detail through the following Preparation Examples, Examples, Comparative Examples, and Experimental Examples.

Example 1. According to the present invention CSP Preparation of mixed extract

A mixture of health, snail, and root stems mixed at a weight ratio of 2.9:3.9:3.2 was extracted with 50% ethanol at 70°C for 6 hours, cooled to room temperature, and concentrated under reduced pressure to obtain a CSP mixed extract. The obtained extract was stored in a cool place at 20°C for 2 days, aged, and then used in the experiment.

Comparative example 1. Preparation of extract derived solely from health

The extract was extracted using 50% ethanol at 70°C for 6 hours, cooled to room temperature, and concentrated under reduced pressure. The obtained extract was stored in a cool place at 20°C for 2 days, aged, and then used in the experiment.

Comparative example 2. Angular Preparation of singly extracted extract

The crust was extracted with 50% ethanol at 70°C for 6 hours, cooled to room temperature, and concentrated under reduced pressure to obtain an extract. The obtained extract was stored in a cool place at 20°C for 2 days, aged, and then used in the experiment.

Comparative example 3. The creeping stem Preparation of singly extracted extract

The extract was extracted using 50% ethanol at 70°C for 6 hours, cooled to room temperature, and concentrated under reduced pressure. The obtained extract was stored in a cool place at 20°C for 2 days, aged, and then used.

Experiment example 1. Check cell viability - MTT assay

The degree of effect on cell viability of the samples obtained in Example 1 and Comparative Examples 1 to 3 was measured. The samples obtained in Example 1 and Comparative Examples 1 to 3 were suspended in purified water and formulated at different concentrations, and cell viability was measured using the following method.

1) Experiment method

Cytotoxicity and proliferation experiments were performed as follows. The cultured keratinocyte cell line HaCaT cells were dispensed at 5,000 cells/well in a 96-well microplate and cultured in a thermostat for 30 minutes, and the samples obtained in Example 1 and Comparative Examples 1 to 3 were administered at different concentrations and cultured for 72 hours. . Thiazoline blue was then administered and further cultured for 4 hours. All culture medium was discarded, reaction stop solution was added to each well of the microplate, stirred for 5 minutes, and absorbance was measured at 570 nm. The control group was co-cultured under optimal conditions for cell growth by administering 10% Fetal Bovine Serum (FBS) medium equal to the sample injection amount. The cell proliferation of the control group was set at 100% and the cell proliferation rate of the sample injection experimental group was calculated. .

2) Experiment results

The cell proliferation effect was calculated by Equation 1, and the results are shown in Table 1 below.

Cell viability (%) Sample processing concentration (%) 0(%) 0.01(%) 0.05(%) 0.1(%) 0.25(%) 0.5(%) 1.0(%) Example 1 100.0 168.6 179.8 178.0 145.8 141.0 121.4 Comparative Example 1 100.0 135.3 139.4 139.5 138.9 138.7 118.5 Comparative example 2 100.0 110.1 113.4 113.7 120.6 122.6 116.8 Comparative Example 3 100.0 111.2 126.7 149.0 116.3 110.0 105.3

As a result of the experiment, as shown in Table 1, no significant toxicity was observed in the compositions according to Example 1 and Comparative Examples 1 to 3.

Experiment example 2. Confirmation of anti-inflammatory activity 1 ( NO production inhibition)

1) Experiment method

Raw 264.7 cells, mouse macrophages, were distributed in a 6-well plate at a concentration of 3.5Х10 ⁵ cells/well and cultured for 24 hours. Afterwards, each well was replaced with cell medium containing diluted samples prepared in Examples 1 to 7 at the concentrations shown in Table 10. As a stimulus, 1 μg of LPS (Lipopolysaccharide) was treated and cultured for 24 hours. Take 100 ㎕ of the supernatant and transfer it to a 96-well plate, add 100 ㎕ of Griess solution each, react at room temperature for 10 minutes, measure the absorbance at 540 nm to determine NO inhibition activity, and the results are shown in Table 2 below. It was.

NO inhibitiona activity(%) Sample processing concentration (%) 0.01(%) 0.05(%) 0.1(%) 0.25(%) 0.5(%) 1.0(%) Example 1 29.0 40.4 55.7 71.2 73.6 76.7 Comparative Example 1 19.0 28.1 36.5 49.6 49.9 50.5 Comparative example 2 17.3 27.6 28.9 35.8 46.2 47.8 Comparative Example 3 11.9 29.7 33.0 36.3 40.4 52.8

As a result, it was confirmed that both Example 1 and Comparative Examples 1 to 3 had the effect of suppressing NO production in a concentration-dependent manner. In particular, in the case of Example 1, which was extracted by mixing health, gonak, and eoreum stems, it was confirmed that the NO production inhibitory effect was further increased compared to Comparative Examples 1 to 3, which were single extracts of health, gonak, and eoreum stems.

Experiment example 3. Confirmation of anti-inflammatory activity 2 ( TNF - alpha inhibitory ability )

1) Experiment method

RAW 264.7 cells, which are macrophages, were cultured in Dulbecco' modified Eagle' medium (DMEM) supplemented with 10% (v/v) fetal bovine serum, streptomycin, and penicillin at approximately 37°C and 5% CO ₂ and cultured in a 48 well plate. It was dispensed in an amount of 2×10 ⁵ cells/well.

Next, each of the compositions prepared in Example 1 and Comparative Examples 1 to 3 were treated according to concentration, stimulated with LPS (1 μg/mL), cultured for 24 hours, and the cell culture medium was collected and analyzed with an ELISA kit (R&D System Inc. Minneapolis). , MN, USA) was used to measure the amount of TNF-α. The amount of TNF-α was quantified using the TNF-α standard curve for each concentration included in the kit. The amount of TNF-α produced in the control group stimulated with LPS (1 μg/mL) but not treated with the composition was about 715.79. The results are shown in Table 3 below.

TNF-α production amount (kit measurement value) Sample treatment concentration (%) 0.05(%) 0.1(%) 0.25(%) 0.5(%) 1.0(%) Example 1 506.82 444.19 397.76 370.86 340.96 Comparative Example 1 678.25 646.85 633.64 588.14 577.44 Comparative example 2 675.43 653.42 622.33 608.33 559.22 Comparative Example 3 688.32 654.36 632.32 594.25 563.33

As a result, it was confirmed that Example 1 and Comparative Examples 1 to 3 all had the effect of suppressing TNF-α production in a concentration-dependent manner. In particular, in the case of Example 1, which was extracted by mixing health, gonak, and eoreum stems, it was confirmed that the inhibitory effect on TNF-α production was further increased compared to Comparative Examples 1 to 3, which were single extracts of health, gonak, and eoreum stems.

Formulation example 1. Toner formulation preparation

An example of a toner formulation using the CSP mixed extract according to the present invention is shown in Table 4 below.

number Raw material Content (% by weight) Content ratio in raw materials (%) One Example 1 2.00 2 glycerin 5.00 3 Methylpropanediol 3.00 4 Betaine 1.00 5 Polyglyceryl-10 Oleate 0.50 44% Polyglyceryl-10 Stearate 56% 6 1,2-hexanediol 1.20 7 Disodium EDTA 0.02 8 antiseptic a very small amount 9 Spices a very small amount 10 Purified water remaining amount

Formulation example 2. Lotion formulation manufacturing

Prescription examples of lotions using the CSP mixed extract according to the present invention are shown in Table 5 below.

number Raw material Content (% by weight) Content ratio in raw materials (%) One Example 1 2.00 2 Caprylic/Capric Triglyceride 5.00 3 Cetearyl alcohol 1.00 4 Stearic Acid 0.50 5 glycerin 5.00 6 Methylpropanediol 3.00 7 propanediol 3.00 8 Dimethicone 0.50 9 Cyclopentasiloxane 1.00 65% Cyclohexasiloxane 35% 10 Cetearyl olivate 1.00 50-70% Sorbitan Olivate 35-50% 11 Polyglyceryl-3methylglucose distearate 1.00 12 1,2-hexanediol 1.20 13 Glyceryl Stearate 0.50 14 Polysorbate 60 0.30 15 Tromethamine 0.18 16 Disodium EDTA 0.02 17 Ammonium Acryloyl Dimethyl Taurate/VPicopolymer 0.10 18 Sodium polyacrylate 0.10 55-65% Hydrogenated polydecene 30-40% Trideceth-6 < 5% 19 carbomer 0.10 20 xanthan gum 0.05 21 antiseptic a very small amount 22 Spices a very small amount 23 Purified water remaining amount

Formulation example 3. Cream formulation preparation

Prescription examples of creams using the CSP mixed extract according to the present invention are shown in Table 6 below.

number Raw material Content (% by weight) Content ratio in raw materials (%) One Example 1 2.00 2 Caprylic/Capric Triglyceride 7.00 3 dicaprylyl carbonate 3.00 4 Cetearyl alcohol 2.00 5 Stearic Acid 0.20 6 glycerin 5.00 7 propanediol 5.00 8 Dimethicone 0.50 9 Cyclopentasiloxane 1.00 65% Cyclohexasiloxane 35% 10 1,2-hexanediol 1.20 11 trehalose 0.50 12 Glyceryl Stearate Citrate 3.00 13 Glyceryl Stearate 0.30 14 Polysorbate 60 0.30 15 Tromethamine 0.18 16 Disodium EDTA 0.02 17 Ammonium Acryloyl Dimethyl Taurate/VPicopolymer 0.10 18 Sodium polyacrylate 0.40 55-65% Hydrogenated polydecene 30-40% Trideceth-6 < 5% 19 carbomer 0.20 20 xanthan gum 0.05 21 Sodium Hyaluronate 0.005 22 antiseptic a very small amount 23 Spices a very small amount 24 Purified water remaining amount

Although the present invention has been described with the accompanying drawings, this is only one example among various embodiments including the gist of the present invention, and is intended to enable those skilled in the art to easily implement the present invention. For this purpose, it is clear that the present invention is not limited to the embodiments described above. Accordingly, the scope of protection of the present invention should be interpreted in accordance with the following claims, and all technical ideas within the equivalent scope by change, substitution, substitution, etc. without departing from the gist of the present invention are subject to the rights of the present invention. will be included In addition, it should be clarified that some of the configurations in the drawings are provided in an exaggerated or reduced form than the actual figure for the purpose of explaining the configuration more clearly.

(S10): Mixture preparation step
(S20): Extraction step
(S30): Reduced pressure concentration step

Claims (5)

A cosmetic composition effective in improving skin inflammation containing CSP, characterized in that it contains a CSP mixed extract obtained by extracting a mixture of health, radish, and root stems.
According to paragraph 1,
The mixture is a cosmetic composition effective in improving skin inflammation containing CSP, characterized in that the mixture contains healthy, succulent, and eureum stems at a weight ratio of 0.5 ~ 10.0: 0.5 ~ 10.0: 0.5 ~ 10.0, respectively.
According to paragraph 1,
The CSP mixed extract is characterized in that it is extracted with any one extraction solvent selected from the group consisting of purified water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, butylacetate, and 1,3-butylene glycol. A cosmetic composition effective in improving skin inflammation containing CSP.
According to paragraph 1,
A cosmetic composition effective in improving skin inflammation containing CSP, comprising the CSP mixed extract as an active ingredient and having an anti-inflammatory effect.
According to paragraph 1,
Containing the above CSP mixed extract as an active ingredient, lotion, skin, lotion, cream, foundation, essence, gel, pack, emulsified sunscreen cream, emulsified foundation, emulsified makeup base, oil cake-type foundation, two-way cake , or a cosmetic composition, characterized in that it is manufactured in the form of a powder pact.