KR100776346B1 - Composition with anti-dandruff, anti-inflammatory activity, containing nasturtium, succinate, sewage, and half-mixed herbal extract - Google Patents

Abstract

The present invention contains a mixed extract extracted from hanryeoncho, sukjihwang, sewage and contrary having antibacterial, anti-inflammatory effect on dandruff causative agents of Pitti Los form Ovalle (Pityrosporum ovale) breeding and inflammatory activity, which may cause irritation to the scalp, as an active ingredient The present invention relates to a pharmaceutical composition and cosmetic composition for external skin, wherein the extracts of Nasturtium, Sukji-hwang, Sewao and Ban-Hae are inhibiting dandruff, anti-inflammatory effect, and lipoxydase activity. Since it shows efficacy, it can be usefully used for the prevention and treatment of dandruff and inflammation.

Description

A composition comprising an extract Eclipta prostrata L., Rehmannia glutinosa Liboschtz var. purpurea Makino, Polygonum multiflorium Thunb. and Pinellia ternata Breit. showing anti-dandruff and anti-inflammatory activity}

The present invention relates to an external skin pharmaceutical composition and a cosmetic composition containing an extract of nasturtium, succinate, sesame and half-harvested herbal medicines having antibacterial and anti-inflammatory effects on dandruff propagation and inflammatory action causing irritation to the scalp.

The types and features of the scalp are as follows.

   Normal scalp refers to the condition of the scalp, which is a standard for determining the type of scalp, and scalp tone has a blue-white milky color, and it is a clean state without foreign substances, that is, aging keratin or sebum oxide.

   Dry scalp is very dry due to poor secretion of oil and moisture of the scalp, and hair also feels crumbly. Excess stratum corneum and dandruff accumulated in the scalp is not properly supplied with nutrients, keratin is seen to occur badly.

Oily scalp is a type caused by excessive sebum secretion in sebaceous glands or poor sebum secretion around pores. Sebum in the scalp is entangled with keratin or dandruff to block the pores, causing sebum to flow back, causing inflammation and hair loss.

Dandruff scalp is a type of scalp in which dandruff increases abnormally due to abnormal growth of dandruff bacteria. Dandruff is largely divided into dry and oily and delayed management can lead to inflammation and hair loss.

   Sensitive scalp refers to a case where keratin of the scalp is more than necessary or sensitive to stress, and the thickness of the hair is also thin and elastic. In terms of diagnostics, the scalp has a red color as a whole and capillaries appear in various places on the screen. Inflammation can easily occur, and in severe cases, hair loss may develop.

   Hair loss-type scalp rarely loses hair temporarily when hair loss begins, and gradually thins and leads to hair loss. The characteristics of the scalp are that the hair loses its elasticity and the scalp tone is yellowish or reddish. This symptom is caused by the blood not moving smoothly inside the scalp, or foreign matter (ie sebum oxide or aging keratin) accumulated on the scalp for a long time.

The deterioration of the physiological function of the scalp is caused by the blockage of hair follicles, the epidermal outlet of the hair, by the excessive generation of dandruff. This causes hair root deterioration. In addition, a lot of dandruff is broken down by bacteria, the decomposition products irritate the scalp, causing the sinus cavities accompanied by itching or inflammation (Anbongjeon, Jintae, skin aging and cosmetics , crisp yarn, p288, 1999).

Dandruff is a drop of dead cells. Dandruff is a skin condition that causes dead cells in the scalp (skin of the head) to fall off more quickly than normal. The cause of dandruff is abnormally fast cell replacement. The dandruff causative agent, Pityrosporum ovale , has everyone and is present in abundant sebaceous glands, ie around hair. Petey Los formaldehyde proliferation and increased activity of Ovalle has become noted as a major factor in the relationship with dandruff aggravate dandruff and itching (ganggyeonghui, such as dermatology, billing cultural history, pp156 ~ 163, 2002). The cause of dandruff is still unknown. However, it is known to worsen due to stress, irregular living, excessive sweating.

As prior arts, Korean Patent Publication Nos. 10-2005-0047810 and 10-1992-0014460 disclose the effects of epigallocatechin galate (EGCG) and horsetail extract on dandruff prevention, respectively. No. 10-1992-0014460 discloses the effect on the hair loss prevention of horsetail extract.

In order to prevent or improve the condition of capillaries, hair follicles, sebaceous glands and epidermis due to abnormal changes in the scalp, various preparations, skin hormones such as female hormones, vitamins, amino acids, herbal extracts, various fungicides, keratinicides and sensitizing dyes And peripheral nerve stimulants such as menthol have been used in hair tonic compositions. To date, however, there has been practically no natural preparation for simultaneously relieving dandruff and inflammation of the scalp.

Nasturtium ( Eclipta prostrata L. ) belongs to the Asteraceae, an annual herb, about 40cm high. The leaves are willow-shaped. In summer and autumn, round flowers hang on the leaf axils. It grows in low mountains and fields in central and southern regions. Ingredients include wedellalactone, nicotine and coumarin compounds. When fresh plant juice gets on the cloth, it initially turns colorless, but gradually turns to a dark-colored black because of the wedellalactone.

The application of nasturtium is used for swelling and various wounds by stopping the blood and removing pus in the private treatment and folklore, and the juice acts to blacken hair or make hairs come out (attention, ingredients and use of herbal medicine , January Written, p733, 1984).

Suzuki is the yellow ( Rehmannia glutinosa Liboschtz var. Purpurea Makino) is washed with water and steamed several times with alcohol to give a black luster to dry. Chihwang is a common ginseng plant, perennial herb, 15-25cm high. It is long oval or long oval. In early summer, branched pink flowers grow on the top of stems. At the root are the iridoid glycosides catalpol and mannitol and lechmanine. It is due to Catalfall that the black color of the roots is dried or steamed. Luteolin and chrysoriol were also identified. There are also alkaloids, flavonoids and carotenoids, but their composition is unknown. Application method is blood in motion Treatment medicine, tonic medicine, pimeot about, Pee Maggie drugs, about which beams the kidneys writes anemia, illness weakness, hematemesis, uterine bleeding, tuberculosis breakdown (statement of interest, composition and use of herbs, January Worth, p656, 1984).

Sewage ( Polygonum multiflorium Thunb.) Is a genus of perennial plants. The roots form a thick mass. The leaves are heart shaped and stick together. In autumn, small white flowers bloom and are planted all over the country. Sewage refers to roots, which are carved in autumn and washed in water and dried in the sun. The root contains 1.8% oxymethylatraquinone derivative, about 45% starch, about 3% essential oil and 3.7% lecithin. The application of sewage is to use roots for skin diseases such as postpartum and senile constipation, scabies and eczema. Sewage has long been used as a tonic, gangjeong, and longevity medicine. Originally called this plant, it is said that a man named Shouao ate this herb, ate it, became black, and lived up to 160 years old, and it was called sewage. (Paintings, Ingredients and Use of Herbs , January, p. 1984, p. 1984) ).

It is a tuber of Pinellia ternata Breit., A perennial herb that is 15 ~ 30cm long as a cheonnamseong plant. It is called half-hearted because its leaves fall in early summer. Main ingredients are ether extract, about 1%, essential oil 0.003 ~ 0.013%, β-sitosterol and its glycosides, choline (0.015%), triterpene compounds, glucuronic acid and its derivatives, aspartic acid, arginine, lysine, ornithine, serine, In addition to glycine, alanine, and citroline, there are glycosides, glucose, and rhamnose released in water. The contrary application was to stop vomiting in the synergistic therapy and to use it for sedation, sputum, cough, dizziness, acute gastritis and insomnia. In the private sector, crushed fresh tubers and ginger are used to apply the juice to alopecia (interest, ingredient and use of herbal medicine , p. 322, 1984).

Accordingly, the present inventors have a strong antibacterial activity against the dandruff causing bacteria Pityrosporum ovale, and screened various kinds of natural products by selecting a substance that can inhibit inflammation of the scalp, Naechocho, Sukjihwang, Sewage and Banha Mixed herbal extracts including the confirmed that the antimicrobial and anti-inflammatory effect at the same time, the experiment was carried out under various conditions in order to maximize the efficacy to complete the present invention by confirming the optimum ratio.

The present invention is a mixture of herbal extracts containing hanryeoncho, sukjihwang, sewage and contrary having antibacterial, anti-inflammatory effect on dandruff causative agents of Pitti Los form Ovalle (Pityrosporum ovale) breeding and inflammatory activity, which may cause irritation to the scalp, as an active ingredient An object of the present invention is to provide an external skin pharmaceutical composition and a cosmetic composition containing.

In order to achieve the above object, the present invention provides a skin external pharmaceutical composition for the prevention and treatment of dandruff and inflammation containing a mixed herbal extract including nasturtium, succinate, sewage and halved as an active ingredient having dandruff and inflammation inhibitory effect. do.

The pharmaceutical composition comprises a cream, gel, patch, spray, ointment, warning, lotion, linen, pasta or cataplasma formulation.

In another aspect, the present invention provides a cosmetic composition for the prevention and improvement of dandruff and inflammation containing a mixed herbal extract including nasturtium, succinate, sewage, halved as an active ingredient having anti-dandruff and inflammation.

In addition, the cosmetic composition is, for example, hair tonic, hair conditioner, hair lotion, shampoo, hair rinse, treatment, hair cream, hair oil, hair drying agent, hair preserving agent, hair colorant, hair wave agent, hair bleaching agent, Formulations for hair cosmetics such as hair gels, hair glazes, hairdressers, hair lacquers, hair moisturizers, hair mousses and hair sprays, lotions, skins, lotions, nourishing lotions, nourishing creams, massage creams, essences and packs Include.

Each herbal medicine of the present invention includes all herbal medicines derived from the same plant, and the composition ratio of the individual compositions is not limited thereto, but preferably the individual weight composition ratio of Nasturtium, Sukji sulfur, sewage and half is about 1-10. : 1 to 10: 1 to 10: 1, more preferably about 1 to 5: 1 to 5: 1 to 5: 1, and most preferably 1 to 2: 1 to 2: 1 to 2: 1.

The extract as defined herein is at least one solvent selected from the group consisting of water, ethanol, methanol, propanol, butanol, acetone, ethyl acetate, hexane, butylene glycol, hydrous butylene glycol, propylene glycol, hydrous propylene glycol, hydrous glycerin It is characterized by being extracted.

Hereinafter, the present invention will be described in detail.

   The mixed herbal extract comprising nasturtium, succinomyceum, sewage, and half of the present invention is dried after drying all the nasturtium, succinate, sewage, and half of the seed, crushed in the case of seed, and finely cut in the case of root or rhizome, and then the medicine of the herbal volume 1 to 20 times, preferably about 10 to 15 times water, lower alcohol or a mixed solvent having a mixing ratio of about 1: 0.1 to 1:10, preferably 1: 1 to 1: 3 DEG C, preferably at 1-40 DEG C for about 1-30 days, preferably about 1-15 DEG C, or 10-100 DEG C, preferably 40-100 DEG C at about 30 DEG C extraction temperature. Minutes to 2 days, preferably about 1 hour to 1 day can be obtained by extraction methods such as ultrasonic extraction, reflux extraction.

The extract can be used in 0.001 to 90% by weight, preferably 0.01 to 10% by weight based on the total weight of the skin external pharmaceutical composition or cosmetic composition.

The external skin pharmaceutical composition containing the extract of the present invention is a skin external preparation having an anti-dandruff and inflammation inhibitory effect, such as a cream, gel, patch, spray, ointment, warning, lotion, linen, pasta or cataplasma. It may be prepared and used as a pharmaceutical composition in the form of an external preparation, but is not limited thereto.

Preferred dosages of the extracts of the present invention vary depending on the condition and weight of the patient, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art. However, for the preferred effect, the extract of the present invention is preferably administered at 0.0001 to 100 mg / kg, preferably 0.001 to 10 mg / kg per day. Administration may be administered once a day or may be divided several times. The dosage does not limit the scope of the invention in any aspect.

In addition, the extract of the present invention can be used in various ways, such as cosmetics and face wash having an anti-dandruff and inflammation inhibitory effect.

 Products to which the composition can be added include, for example, cosmetics such as lotion, skin, lotion, nourishing lotion, nourishing cream, massage cream, essence and pack, and cleansing, face wash, soap, treatment, essence, etc. have.

Cosmetics of the present invention comprises a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids and seaweed extract.

The water-soluble vitamins may be any compound that can be incorporated into cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, and the like. Their salts (thiamine hydrochloride, sodium ascorbate salt, etc.) and derivatives (ascorbic acid-2-sodium phosphate salt, ascorbic acid-2-magnesium phosphate salt, etc.) may also be used in the water-soluble vitamins that can be used in the present invention. Included. The water-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification from microorganism culture, enzyme method or chemical synthesis.

The oil-soluble vitamin may be any compound that can be incorporated into cosmetics, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), and the like. And derivatives thereof (ascorbic palmitate, ascorbic stearate, ascorbic acid dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherolvitamin E, dl-pantothenyl alcohol, D-pantothenyl alcohol, pantotenylethyl Ethers, etc.) are also included in the oil-soluble vitamins used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification of microorganism culture, enzyme or chemical synthesis.

The polymer peptide may be any compound as long as it can be incorporated into cosmetics. Preferably, collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin and the like can be given. Polymeric peptides can be purified and obtained by conventional methods such as purification from microbial cultures, enzymatic methods or chemical synthesis methods, or can be purified and used from natural products such as dermis and pig silk such as pigs and cattle.

The polymer polysaccharide may be any compound as long as it can be blended into cosmetics. Preferably, hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt, etc.) may be mentioned. For example, chondroitin sulfate or its salt, etc. can be normally purified from a mammal or fish.

The sphingolipid may be any compound as long as it can be blended into cosmetics. Preferably, ceramide, phytosphingosine, sphingosaccharide lipid, etc. may be mentioned. Sphingo lipids can usually be purified from mammals, fish, shellfish, yeasts or plants by conventional methods or obtained by chemical synthesis.

The seaweed extract may be any compound as long as it can be blended into cosmetics. Preferably, the seaweed extract may include brown algae extract, red algae extract, green algae extract, and the like. Also, calginine, arginic acid, sodium arginate, Potassium arginate and the like are also included in the seaweed extract used in the present invention. Seaweed extract can be obtained by purification from seaweed by conventional methods.

In addition to the said essential component, you may mix | blend the cosmetics of this invention with the other components normally mix | blended with cosmetics as needed.

Other components that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavorings, Blood circulation accelerators, cooling agents, restriction agents, purified water and the like.

Examples of the fat or oil component include ester fats, hydrocarbon fats, silicone fats, fluorine fats, animal fats, and vegetable fats and oils.

As ester fats and oils, glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl mystinate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl acid isocetyl, isostyl acid isostearyl, isostaryl palmitate, octylate acid octyldodecyl, isostearic acid isetyl, diethyl sebacate, adipine Acid isopropyl, isoalkyl neopentane, tri (capryl, capric acid) glyceryl, trimethyl ethyl trimethylol propane, triisostearic acid trimethylol propane, tetra 2-ethylhexanoic penta erythritol Cetyl caprylate, lauric acid decyl, hexyl laurate, decyl myristin, myristin acid myristyl, myritic acid cetyl, stearyl stearate, decyl oleate, rininooleic acid , Isostearyl laurate, isotridecyl myristin, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecate oleate, octylate decyl oleate, octyl dodecyl linoleate, isopropyl isopropyl acid, 2 -Cetostearyl ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicapric acid, propylene glycol dicacapate, capric acid Propylene Glycol, Dipentane Neopentyl Glycol, Dioctanoate Neopentyl Glycol, Tricaprylic Acid Glyceryl, Triundecyl Glyceryl, Triisopalmitinate Glyceryl, Triisostearate Glyceryl, Neopentane Octyldodecyl Isostearyl octanoate, octyl isononate, hexyl decyl neodecanoate, octyl dodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, Sothete octylate, polyglycerol oleate, polyglycerine isostearate, triisocetyl citrate, triisoalkyl citrate, triisoctyl citrate, lauryl lactate, myritic lactate, octyl lactate, octyl lactate, tricitric acid Ethyl, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malic acid, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipicate, diisopropyl sebacinate, Dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, physteryl isostearate, phytic oleate, 12-Steloylhydroxystearate isocetyl, 12-Steloylhydroxystearate stearyl, 12-steal One hydroxy stearic acid and the like esters such as cetearyl source.

Hydrocarbon-based fats and oils, such as squalene, a liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, a liquid isoparaffin, polybutene, microcrystal wax, and a vaseline, etc. are mentioned as a hydrocarbon-type fats and oils.

Examples of the silicone-based oils and fats include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane, methylcetyloxysiloxane copolymer, dimethylsiloxane and methylsteoxysiloxane copolymer, and alkyl. Modified silicone oil, amino modified silicone oil and the like.

Perfluoro polyether etc. are mentioned as fluorine-based fats and oils.

Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, soybean oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil. , Cottonseed oil, Palm oil, Cucumber nut oil, Wheat germ oil, Rice germ oil, Shea butter, Walnut colostrum oil, Marker demia nut oil, Meadow home oil, Egg yolk oil, Uji, Horse oil, Mink oil, Orange rape oil, Jojoba oil And animal or plant fats and oils such as candeler wax, carnava wax, liquid lanolin and hardened castor oil.

Examples of the moisturizing agent include a water-soluble low molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, and a fat-soluble polymer.

Water-soluble low molecular humectants include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerol B (polymerization degree n = 2 or more), lactic acid, lactic acid salt, etc. are mentioned.

Examples of the fat-soluble low molecular humectants include cholesterol and cholesterol esters.

Examples of the water-soluble polymer include carboxyvinyl polymer, polyasparaginate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water soluble chitin, chitosan, and dextrin. Can be.

Examples of the fat-soluble polymers include polyvinylpyrrolidone-eicosene copolymers, polyvinylpyrrolidone-hexadecene copolymers, nitrocellulose, dextrin fatty acid esters, polymer silicones, and the like.

Examples of the emollient include long-chain acyl glutamic acid cholesteryl esters, hydroxy stearic acid cholesterol, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl esters, and the like.

As surfactant, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant, etc. are mentioned.

As the nonionic surfactant, self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hardened castor oil, POE castor oil, POE / POP (polyoxyethylene / polyoxypropylene) copolymer, POE / POP alkyl ether, polyether modified silicone, lauric acid Alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, etc. are mentioned.

Anionic surfactants include fatty acid soaps, alpha-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkylamide sulfates, alkyl phosphates, POE alkylphosphates, and alkylamides. Phosphates, alkyloylalkyltaurine salts, N-acylamino acid salts, POE alkyl ether carboxylate salts, alkyl sulfosuccinate salts, sodium alkyl sulfo acetates, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, and the like. Can be.

As cationic surfactant, alkyl trimethylammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium bromide, behenyl trimethyl ammonium chloride, chloride Benzalkonium, diethylaminoethyl stearate, dimethylaminopropyl stearate, lanolin derivatives, quaternary ammonium salts, and the like.

Examples of amphoteric surfactants include the carboxybetaine type, the amide betain type, the sulfobetain type, the hydroxysulfobetain type, the amide sulfobetain type, the phosphobetaine type, the aminocarboxylate type, the imidazoline derivative type, and the amideamine type. An amphoteric surfactant etc. are mentioned.

Organic and inorganic pigments include silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium film mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminum oxide Inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium hydroxide, calamine and composites thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene, styrene copolymer, Organic pigments such as silk powder, cellulose, CI pigment yellow, CI pigment orange, and composite pigments of these inorganic pigments and organic pigments;

As organic powder, Metal soaps, such as a calcium stearate; Alkyl phosphate metal salts such as sodium cetylinate, zinc lauryl acid and calcium laurate; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroylglycine calcium; Amide sulfonic acid polyvalent metal salts, such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-epsilon-lauroyl-L-lysine, N-epsilon-palmitolyzine, N-alpha-paratoylol nitin, N-alpha-lauroyl arginine, N-alpha-cured fatty acid acyl arginine -Acyl basic amino acid; N-acyl polypeptides, such as N-lauroyl glycyl glycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene-styrene copolymer, ethylene tetrafluoride and the like.

Examples of the ultraviolet absorber include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoic acid, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomentyl salicylic acid and benzyl cinnamic acid. , Paramethoxy cinnamic acid-2-ethoxyethyl, paramethoxy cinnamic acid octyl, diparamethoxy cinnamic acid mono-2-ethylhexaneglyceryl, paramethoxy cinnamic acid isopropyl, diisopropyl diisopropyl cinnamic acid ester mixture, wuro Canonic acid, ethyl urokanoate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium sulfonate, dihydroxybenzophenone , Tetrahydroxybenzophenone, 4- tert -butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino- p- (carbo-2'-ethylhexyl-1'-oxy) -1 , 3,5-triazine, 2- (2-hi And the like can be mentioned hydroxy-5-methylphenyl) benzotriazole.

As fungicides, hinokithiol, trichloric acid, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zinphylthione, benzalkonium chloride, Photosensitizer No. 301, mononitrourecosodium sodium, undecylenic acid, etc. are mentioned.

Examples of the antioxidant include butylhydroxyanisole, propyl gallic acid, and erythorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fmaric acid, sodium pmarate, succinic acid, sodium succinate, sodium hydroxide, sodium dihydrogen phosphate, and the like.

Examples of the alcohol include higher alcohols such as cetyl alcohol.

Moreover, the compounding component which may be added other than this is not limited to this, Moreover, Although all said components can be mix | blended within the range which does not impair the objective and effect of this invention, Preferably it is 0.01-5% weight percentage with respect to a total weight, More preferably 0.01-3% by weight.

The cosmetic of the present invention may take the form of a solution, an emulsion, a viscous mixture, or the like.

Ingredients included in the cosmetic composition of the present invention may include components commonly used in cosmetic compositions in addition to the extract as an active ingredient, for example, conventional auxiliary agents such as stabilizers, solubilizers, vitamins, pigments and flavorings. And carriers.

The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, and includes, for example, emulsion, cream, lotion, pack, foundation, lotion, beauty solution, hair cosmetic, and the like.

Specifically, the cosmetic composition of the present invention skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisturizing cream, hand cream, foundation, essence, nutrition essence, Formulations of packs, soaps, cleansing foams, cleansing lotions, cleansing creams, body lotions and body cleansers.

When the formulation of the present invention is a paste, cream or gel, animal carriers, vegetable fibers, waxes, paraffins, starches, tracantes, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide, etc. may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating or emulsifying agent is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the dosage form of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

Hereinafter, the present invention will be described in detail by the following Examples and Experimental Examples.

However, the following Examples and Experimental Examples are merely illustrative of the present invention, and the content of the present invention is not limited by the following Examples and Experimental Examples.

Example  1. Preparation of mixed herbal extracts according to the blending ratio

Nayeoncho, Sukjiwang, Sewage and half purchased from Gyeongdong Market are mixed in the weight ratio of Table 1 below, 70% hydrous ethanol (weight%) is added in 7 times the amount of the raw material and extracted by immersion for 5 days at room temperature with a 400 mesh filter cloth Filtered to 0.45um filter and concentrated in a vacuum condenser with a cooler to prepare Examples 1-1 to 1-19.

Raw material (0.1kg) Solvent (kg) Yield (g) Yield compared to raw materials (%) Nasturtium Hungjiwang Shouao Half Example 1-1 One - - - 0.7 3.1 3.1 Example 1-2 - One - - 0.7 13.9 13.9 Example 1-3 - - One - 0.7 8.5 8.5 Example 1-4 - - - One 0.7 8.8 8.8 Example 1-5 One One One One 2.8 24.8 6.2 Example 1-6 2 One One One 3.5 29.5 5.9 Example 1-7 One 2 One One 3.5 52.0 10.4 Example 1-8 One One 2 One 3.5 58.5 11.7 Example 1-9 One One One 2 3.5 42.5 8.5 Example 1-10 2 2 One One 4.2 65.4 10.9 Example 1-11 2 One 2 One 4.2 54.6 9.1 Example 1-12 2 One One 2 4.2 56.4 9.4 Example 1-13 One 2 2 One 4.2 64.8 10.8 Example 1-14 One One 2 2 4.2 612 10.2 Example 1-15 One 2 One 2 4.2 67.8 11.3 Example 1-16 2 2 2 One 4.9 80.5 11.5 Example 1-17 2 2 One 2 4.9 70.7 10.1 Example 1-18 2 One 2 2 4.9 68.6 9.8 Example 1-19 One 2 2 2 4.9 68.4 11.4

Example  2. Preparation of Mixed Herbal Extracts by Extraction Solvents

200g, Sukjihwang 200g, Sewage 200g, Half 100g, which was purchased from Gyeongdong Market, was mixed into 4.9kg of each solvent in Table 2, extracted at room temperature with an extractor for 5 days, filtered through a 400 mesh filter cloth, and filtered with a filter of 0.45um. Examples 2-1 to 2-5 were prepared and used as samples in the following experiment.

Solvent Yield (kg) Solid content (%) Yield compared to raw materials (multiple) Example 2-1 Purified water 3.93 1.87 5.61 Example 2-2 95% ethanol 4.30 0.74 6.14 Example 2-3 30% hydrous propylene glycol 4.11 1.24 5.87 Example 2-4 30% hydrous ethanol 4.19 1.31 5.99 Example 2-5 30% Hydrated Butylene Glycol 4.08 1.20 5.83

Experimental Example  1. Dandruff ( Pityrosporum ovale Antimicrobial effect test

Inhibition of activity against dandruff bacteria of Examples 1-1 to 2-5 was examined.

Strain ( Pityrosporum) ovale : KCCM 50150; ATCC12078) was purchased from the Korea Center for Microbial Conservation, and the seed culture was used for 4 days or more in Luria-Bertani broth. Each sample was dropwise to 1 mg of sample on a circular paper (disc paper, 8 mm in diameter), and after dropping, it was dried for 1 hour at 50 ° C and used for the experiment. First, the Luria-Bertani agar medium (Luria-Bertani agar, DIFCO, USA) was autoclaved (121 ° C., 30 minutes), and the prepared culture was poured into petri-dish and hardened. Was plated in petri-dish and spread. The sample (disc paper) prepared on each petri dish was placed and incubated at 35 ° C. for 3 days to measure the difference in the antimicrobial activity of the sample by the size of the clear zone (diameter, mm) generated around the circular filter. As a result, almost all samples showed antimicrobial activity, and in particular, Examples 1-10, 1-16, and 2-5 showed strong antimicrobial activity (see Table 3).

Dandruff ( Pityrosporum antimicrobial effect on ovale ) Raw material Transparent ring (mm) Raw material Transparent ring (mm) Raw material Transparent ring (mm) Example 1-1 8.9 Example 1-11 9.5 Example 2-2 9.8 Example 1-2 8.5 Example 1-12 9.5 Example 2-3 9.2 Example 1-3 8.6 Example 1-13 9.2 Example 2-4 9.5 Example 1-4 8.4 Example 1-14 9.8 Example 2-5 13.9 Example 1-5 9.1 Example 1-15 10.8 Example 1-6 9.6 Example 1-16 13.2 Example 1-7 9.5 Example 1-17 9.5 Example 1-8 9.8 Example 1-18 11.1 Example 1-9 10.1 Example 1-19 10.5 Example 1-10 10.9 Example 2-1 -

Experimental Example  2. Lipoxysidase ( Lipoxydase Activity inhibition experiment

In order to confirm the inhibitory effect of lipidase activity of Examples 1-1 to 2-5, the experiment was performed as follows (Kim Kyung-man, Journal of Drug Research , 5 , p45, 1996).

50 mL of 0.95 mL of Lipoxydase solution and a concentration of 50 mL of 1.12 mM Linolenic acid in 1.0 mL solution dissolved in 0.1 M sodium phosphate buffer (pH 7.0) It put in and made it react at 25 degreeC for 10 minutes. Sample as a control Solvent is used instead. Blank blank is added with 0.95 mL of buffer instead of lipoxidase solution. Thereafter, 0.5 mL of 20% trichloroacetic acid and 1.0 mL of 0.6% thiobarbituric acid were added, followed by heating and color development in boiling water for 10 minutes and cooling in ice water. 2.0 mL of butanol was added and stirred, followed by centrifugation. The upper layer butanol was measured for absorbance at 535 nm using a spectrophotometer (UV Spectrum).

    Each sample was carried out with the final concentration of the reaction solution 500 ㎍ / ㎖, 1,000 ㎍ / ㎖, the inhibition rate for the enzyme activity was calculated by the following equation (1). As a result of the experiment, Examples 1-10, 1-16, and 2-5 showed high inhibition rates of 50% or more (see Table 4).

Inhibitory Effect of Lipoxydase Activity division % Inhibition division % Inhibition 500 µg / ml 1000 µg / ml 500 µg / ml 1000 µg / ml Example 1-1 9.5 13.8 Example 1-13 12.1 28.8 Example 1-2 5.8 6.1 Example 1-14 7.9 12.7 Example 1-3 7.6 19.4 Example 1-15 5.0 9.4 Example 1-4 8.0 16.3 Example 1-16 37.7 60.4 Example 1-5 11.6 20.5 Example 1-17 15.1 21.0 Example 1-6 6.9 10.1 Example 1-18 13.8 22.6 Example 1-7 16.4 13.8 Example 1-19 8.4 12.8 Example 1-8 12.1 16.4 Example 2-1 10.3 16.7 Example 1-9 9.4 19.2 Example 2-2 6.5 8.6 Example 1-10 30.2 69.7 Example 2-3 11.1 20.4 Example 1-11 13.8 21.9 Example 2-4 5.0 11.6 Example 1-12 14.2 26.4 Example 2-5 48.2 67.5

Experimental Example  3. Dandruff Suppression Experiment

    The dandruff inhibitory effect was measured for Examples 1-10, 1-16, and 2-5, which had anti-dandruff inhibitory and anti-inflammatory effects in the experiment.

    Ten relatively relatively dandruff subjects were tested for one month for the shampoo composition shown in Table 5 below. The weight of the dandruff accumulated for 3 days after washing with a general shampoo before the test was measured, then washed with a shampoo composition of the composition shown in Table 5, and after the end of the test, the weight of the dandruff accumulated for 3 days was evaluated. Accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the dandruff reduction rate was calculated by Equation 2 below. The anti-dandruff effect was judged to be effective only when the dandruff reduction rate was 30% or more. The anti-dandruff effect is shown in Table 6 below.

Examples 1-10 and 1-16 were dissolved in 50% hydrous butylene glycol to 1.2% by weight, and Example 2-5 was applied as it was.

Shampoo recipe 1-10 1-16 2-5 Comparative example Lauryl POE (3) sulfate ester triethanol amine salt (30%) 12.0 12.0 12.0 12.0 Lauryl POE (3) ester sodium salt (30%) 23.0 23.0 23.0 23.0 Lauryl sulfate ether sodium salt (30%) 5.0 5.0 5.0 5.0 Lauryl Dimethyl Amino Betaine (30%) 10.0 10.0 10.0 10.0 Cationized cellulose 0.2 0.2 0.2 0.2 Ethylene Glycol Distearic Acid Ether 2.0 2.0 2.0 2.0 Methyl Paraben 0.2 0.2 0.2 0.2 EDTA-2Na 0.2 0.2 0.2 0.2 Citric acid 0.02 0.02 0.02 0.02 Spices 0.5 0.5 0.5 0.5 Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 1.0 1.0 1.0 - water Add until 100% by weight.

Anti dandruff effect division Average Dandruff Reduction (%) Example 1-10 41.1 Example 1-16 38.6 Example 2-5 63.2 Comparative example 12.0

It describes an example of the formulation of the cosmetic composition comprising a nasturtium herb, Sukji sulfur, sewage and half-harvested herbal extract of the present invention, but the present invention is not intended to limit the present invention is to be described in detail only.

Formulation example  1. Preparation of Hydrophilic Ointment

Raw material weight%   Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 9.00   White vaseline 36.00   Stearyl alcohol 31.00   Ethyl (or methyl) p-oxybenzoate a very small amount   Propylene glycol 19.00   Sodium lauryl sulfate 2.40   Propyl p-oxybenzoate a very small amount system 100.00

Formulation example  2. Flexible Cosmetics skin Manufacturing

Raw material weight%   Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 2.0 1,3-butylene glycol 2.00 glycerin 3.00 Oleyl alcohol 2.00 Polysorbate 20 1.00 ethanol 6.00 antiseptic a very small amount incense a very small amount Purified water Remaining amount system 100.00

Formulation example  3. Milk croissant  Produce

Raw material weight%   Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 5.0 1,3-butylene glycol 4.00 glycerin 3.00 Oleyl alcohol 0.05 Polysorbate 20 1.00 antiseptic a very small amount incense a very small amount Purified water Remaining amount system 100.00

Formulation example  4. Manufacturing of Nutritional Cream

Raw material Formulation Example 4   Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 2.0 Vaseline 5.00 Liquid paraffin 30.00 Beeswax 3.00 Polysorbate 60 1.00 Sorbitan sesquioleate 1.00 1,3-butylene glycol 5.00 glycerin 5.00 antiseptic a very small amount incense a very small amount Purified water Remaining amount system 100.00

Formulation example  5. Massage  Manufacture of cream

Raw material weight%   Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 7.0 glycerin 5.00 Triethanolamine 0.50 Tocopheryl acetate 1.00 Liquid paraffin 5.00 Squalane 5.00 Macadamia Nut Oil 15.00 Polysorbate 60 1.00 Sorbitan sesquioleate 1.00 Carboxy vinyl polymer 0.20 antiseptic a very small amount incense a very small amount Purified water Remaining amount system 100.00

Formulation example  6. Hair shampoo  Produce

 Raw material name  Formulation Example 1  Comparative Formulation Example 1 1.lauryl POE (3) sulfate ester triethanol amine salt (30%) 12.0% 12.0% 2. Lauryl POE (3) ester sodium salt (30%) 23.0% 23.0% 3. Lauryl sulfate ether sodium salt (30%) 5.0% 5.0% 4. Lauryl Dimethyl Amino Betaine (30%) 10.0% 10.0% 5. Cationic Cellulose 0.2% 0.2% 6. Ethylene Glycol Distearic Acid Ether 2.0% 2.0% 7. Methyl Paraben 0.2% 0.2% 8.EDTA-2Na 0.2% 0.2% 9. Citric Acid 0.02% 0.02% 10. Spices 0.5% 0.5% 11. Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 5.0% - 12. Purified Water Remaining amount Remaining amount Sum 100% 100%

Formulation example  7. Preparation of Hair Tonic

  Raw material name  Formulation Example 1  Comparative Formulation Example 1 Resorcinol 0.1% 0.1% 2. Menthol 0.05% 0.05% 3. Panthenol 0.2% 0.2% 4. Salicylic Acid 0.1% 0.1% 5. Tocopheryl Acetate 0.1% 0.1% 6. Pyridoxine Hydrochloride 0.1% 0.1% 7. Castor Oil 5.0% 5.0% 8. Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 5.0% - 9. Pigment Quantity Quantity 10. Spices Quantity Quantity 11.ethanol Quantity Quantity 12. Purified Water Remaining amount Remaining amount Sum 100% 100%

Formulation example  8. Of hair conditioner  Produce

   Raw material name  Formulation Example 2  Comparative Formulation Example 2 1. Cetanol 3.5% 3.5% 2. Self-emulsifying glycerin monostearate 1.5% 1.5% 3. Propylene Glycol 2.5% 2.5% 4. Stearylmethylbenzyl ammonium chloride (25%) 7.0% 7.0% 5. Methyl Paraoxybenzoate 0.3% 0.3% 6. Nasturtium, Sukjihwang, Sewao and Hyacinth Mixed Herbal Extracts 5.0% 5.0% 7. Pigment Quantity Quantity 8. Spices Quantity Quantity 9. Purified water Remaining amount Remaining amount Sum 100% 100%

As described above, the herbal extracts of Hannyeoncho, Sukjihwang, Sewao and Hemichaum according to the present invention inhibit dandruff, anti-inflammatory effect, and lipoxydase activity. Since it shows efficacy, it can be used as a pharmaceutical composition and cosmetic composition for the prevention and treatment of dandruff and inflammation.

Claims (6)

Water, Ethanol, Propylene Glycol, Butylene Glycol, or Mixtures of Mixed Herbal Medicines with Individual Weight Composition of 1 to 10: 1 to 10: 1 to 10: 1 A skin external pharmaceutical composition for preventing and treating dandruff and inflammation containing a solvent-soluble extract as an active ingredient. delete delete Water, Ethanol, Propylene Glycol, Butylene Glycol, or Mixture of Mixed Herbal Medicines with Individual Weight Composition of 1 ~ 10: 1 ~ 10: 1 ~ 10: 1 Cosmetic composition for the prevention and improvement of dandruff and inflammation containing a solvent-soluble extract as an active ingredient. The composition of claim 4, wherein the composition comprises hair tonic, hair conditioner, hair lotion, shampoo, hair rinse, treatment, hair cream, hair oil, hair dryer, hair preservative, hair colorant, hair wave agent, hair bleach, hair Cosmetic compositions in the form of gels, hair glazes, hairdressers, hair lacquers, hair moisturizers, hair mousses or hairsprays, lotions, skins, lotions, nourishing lotions, nourishing creams, massage creams, essences or packs. . delete