KR20180035645A - Lecithin emulsification composition containing lecithin and high-viscosity ester oil - Google Patents

Abstract

The present invention relates to a composition comprising lecithin as an emulsifier or a surfactant, characterized in that it contains a high viscosity ester oil. More specifically, the composition according to the present invention not only exhibits an improved emulsifying effect without an additional emulsifying agent other than lecithin, but also exhibits excellent effects in feelings such as moisturizing feeling of a cosmetic and a medicinal product, and feeling of a feeling of warming.

Description

[0001] The present invention relates to a lecithin emulsification composition containing lecithin and a high viscosity ester oil,

The present invention relates to a lecithin emulsified composition, and relates to a pharmaceutical or cosmetic composition excellent in stability of formulation and excellent in feeling of use.

Generally, emulsions for pharmaceuticals or cosmetics are those in which a water-soluble substance and an oil-soluble substance, which are not mixed with each other in most cases, are dispersed in the form of fine particles in one phase using an emulsifier or a surfactant. The emulsifier or surfactant used is an indispensable element, but on the other hand it dissolves the lipid layer of the skin and causes skin irritation and allergy. In particular, synthetic emulsifiers should be designed in consideration of stability and safety within the shelf life of pharmaceuticals or cosmetics, since skin irritation may increase depending on the content.

In recent years, a pharmacological or cosmetic composition composed of a naturally derived component has been preferred due to the increased awareness of skin safety. However, a natural-derived surfactant tends to have a lower emulsifying power than a synthetic surfactant. Accordingly, efforts have been made to secure emulsion stability by using various naturally occurring surfactants. However, when designing considering both the expiration date and the expiration date, there is a relatively large amount of the surfactant And the like.

On the other hand, lecithin is a representative natural-derived surfactant and is a mixture composed of phosphoric acid, choline, fatty acid, glycerol, glycolipid, triglyceride, phospholipid and the like. In particular, lecithin is known to be a substance having a high affinity for human body similar to skin lipid structure, and it has been reported to be safe for skin to a content of 15% in the case of the leave-on type. However, lecithin has a low HLB (Hydrophile-Lipophile Balance) value and thus has limitations such as a phase change during emulsification. That is, in order to stabilize pharmacy and cosmetics which use lecithin as an emulsifier, it has been difficult to express the merits of lecithin because it is required to additionally employ a non-ionic emulsifier or an ionic emulsifier having a high HLB.

Products using lecithin as a sole emulsifier are manufactured by using high-pressure emulsification method instead of general underwater type emulsification method, such as nanoparticles and liposomes. However, such a technique has disadvantages in that it is not preferable from the economical point of view because the manufacturing cost is increased, and it is difficult to design differently from general emulsification prescription.

Accordingly, there is a continuing need for a lecithin emulsifying composition in which the emulsified state is stably maintained without any other emulsifier besides lecithin.

Korean Registered Patent No. 10-1585922 (published on January 18, 2016) Korean Registered Patent No. 10-0713564 (2007.04.05 Announcement) Korean Registered Patent No. 10-0896697 (issued on May 14, 2009)

 Mary Beth Genter, International Journal of Toxicology, 2001, Vol.20, pp. 21-45

Accordingly, an object of the present invention is to provide an emulsified composition in which an emulsified state is stably maintained in lecithin-based emulsified formulations without lecithin and another emulsifier.

In order to solve the above problems, A composition comprising lecithin as an emulsifier or a surfactant, which comprises a high viscosity ester oil.

The inventors of the present invention have found that emulsifying agents can be easily produced by using a high viscosity ester oil in order to stabilize the emulsification system without the use of a separate emulsifier other than lecithin and that the emulsification stability is effectively increased according to the content ratio of lecithin and high viscosity ester oil Thereby completing the present invention. In addition, when such a composition is a cosmetic composition, it is excellent in feeling in many aspects.

The present invention provides a lecithin emulsion composition additionally comprising a high viscosity ester oil in a composition comprising lecithin as an emulsifier or a surfactant, and preferably provides an underwater type composition. In addition, the lecithin emulsifying composition according to the present invention may be a pharmaceutical or cosmetic composition.

When a pharmaceutical or cosmetic composition according to the present invention is applied, a cosmetic film having less stickiness and uniformity can be obtained. In addition, the affinity of the powder or the emulsion with the skin can be controlled, and the cosmetic or pharmaceutical sustaining effect can be improved by forming a uniform cosmetic film. In addition, by using a polyhydric alcohol and water in combination, the skin-rubbing property can be improved. Further, when the composition for underwater type according to the present invention is applied, cleansing by the lukewarm water is facilitated. In addition, when another cosmetic material is applied after application of an underwater type medicament or a cosmetic material, the cosmetic sustaining effect of the cosmetic material is improved, and the cosmetic material used after the application is also simultaneously removed with hot water.

The lecithin included in the present invention may be natural lecithin, hydrogenated products thereof, and synthetic lecithin extracted from microorganisms such as animal or plant such as egg yolk, soybean, and corn, and Escherichia coli. Specific examples of the lecithin include natural phospholipids such as spartidyl choline, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, egg yolk lecithin and soybean lecithin; Synthetic lecithin such as diureuyl phosphatidylcholine, di-myristoyl phosphatidyl choline, dipalmitoyl phosphatidyl choline, di-stearoyl phosphatidyl choline, dioleoyl phosphatidyl choline, palmitoyl phosphatidyl choline and oleoyl phosphatidyl choline; And hydrogenated lecithin such as hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, hydrogenated phosphatidylcholine, hydrogenated phosphatidylserine, and the like. Among them, hydrogenated lecithin has suitable adhesion to skin and dispersibility in water, and is therefore preferable in view of uniformity of cosmetic film and easiness of cleansing in hot water.

The content of the lecithin is 0.01 to 20% by weight, preferably 0.1 to 10% by weight, based on the total weight of the composition. When the content is less than 0.01, the stability of the composition is remarkably poor. When the content is more than 20% by weight, it is difficult to secure the effect of improving the flaking feeling according to the present invention.

In the present specification, the " high viscosity " ester oil is a paste or wax ester oil, preferably the ester oil has a hardness of 15 to 65 dyne / cm ² (T.Speed 2 cm / min) Phosphorus ester oil.

In addition, the weight-average molecular weight of the high-viscosity ester oil is 550 or more, and when the weight-average molecular weight is 550 or less, the stabilizing effect according to the present invention may be insignificant. Preferably, an ester oil having a boiling point of 650 or higher can be used. In order to ensure the stability of the formulation, it is possible to use an ester oil having a weight average molecular weight of 5500 or less, preferably 3200 or less.

Also preferably, the high viscosity ester oil according to the present invention is an adipate or a fatty acid ester. More preferably, the high viscosity ester oil according to the present invention is selected from the group consisting of dipentaerythritol hexahydroxy stearate / hexa stearate / hexa stearate / hexa stearate / hexarosinate, bis-diglyceryl polyacyl adipate- BIS-DIGLYSERYL POLYACYLADIPATE-2), CHOLESTERYL HYDROXYSTEARATE, EUPHORBIA CERIFERA, OZORAKATE, MICROCRYSTALLINE WAX, DIPENTAERYTHRITE FATTY ACID ESTER, CHOLESTERYL HYDROXYSTEARATE, PHYTOSTERYL HYDROXYSTEARATE, PHYTOSTERYL OLEATE, dipentaerythritol hexahydroxystearate, / Tetrastearate / tetraisostearate (DIPENTAERYTHRITYL HEXAHYDROXYSTEARATE / TETRASTEARATE / TETRAISOTSEARATE), glyceryl ethylhexanoate / stearate / adipate, caprylic / capric / capric / ), Hygrogenated palm oil, and petrolatum. However, the present invention is not limited thereto.

The content of the high viscosity ester oil is 0.01 to 40% by weight, preferably 0.1 to 30% by weight, and more preferably 1 to 25% by weight based on the total weight of the composition. When the content is less than 0.1% by weight, the stability of the composition is remarkably poor. When the content is more than 40% by weight, the composition may show an improper viscosity.

The weight ratio of lecithin to high viscosity ester oil included in the present invention is 1: 0.2 to 1: 150, preferably 1: 0.5 to 1: 100, in terms of lecithin: high viscosity ester oil. When the weight ratio is less than 1: 0.2, the emulsion stability improvement according to the present invention is insignificant. When the weight ratio is more than 1: 150, the stickiness of the composition increases sharply.

The lecithin emulsifying composition according to the present invention can be used in a variety of cosmetics such as polyhydric alcohols, humectants, preservatives, antibacterial agents, antioxidants, pH adjusting agents, chelating agents, refreshing agents, anti- Cosmetic ingredients, and vitamin ingredients, and the like.

Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, tetramethylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, pentamethylene glycol Dihydric alcohols; Trihydric alcohols such as glycerin, trimethylol propane and 1,2,6-hexatriol; Quaternary alcohols such as pentaerythritol; Pentahydric alcohols such as xylitol; Polyhydric alcohol polymers such as diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol and polyglycerin; Divalent alcohol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol diethyl ether, and ethylene glycol dibutyl ether; Dihydric alcohol alkyl ethers such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol monobutyl ether; Divalent alcohol ether esters such as ethylene glycol monomethyl ether acetate and propylene glycol monomethyl ether acetate; Glycerin monoalkyl ethers such as butyl alcohol; And sugar alcohols such as sorbitol, melitol, maltotriose, mannitol, sucrose, erythritol, fructose, maltose, xylitol and starch equivalent reduced alcohol. Among these, dipropylene glycol and 1,3-butylene glycol are preferable in terms of giving a smooth and moist feeling and forming a uniform cosmetic film, but are not limited thereto.

Examples of the moisturizing agent include, but are not limited to, hyaluronic acid, squalane, chondroitin sulfate, and pyrrolidonecarboxylic acid salt.

The antiseptic or antimicrobial agent may be selected from the group consisting of paraoxybenzoic acid ester, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, phenoxyethanol, salicylic acid, phenolics, parachlorometacresol, hexachlorophen, benzalkonium chloride, chlorhexidine chloride, Dithium, photosensitizer, isopropylmethylphenol and the like can be used, but the present invention is not limited thereto.

Examples of the antioxidant include tocopherol, butylhydroxyanisole, dibutylhydroxytoluene, and the like, but are not limited thereto.

The pH adjusting agent may be lactic acid, lactic acid salt, citric acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, potassium carbonate, sodium hydrogen chloride, ammonium hydrogen carbonate and the like.

The chelating agent may be selected from the group consisting of sodium edetate, Sodium polyphosphate, sodium metaphosphate, phosphate, hydroxyethanediphosphone, and the like, but not limited thereto.

Examples of the refreshing agent include, but are not limited to, L-menthol, camphor, peppermint oil, peppermint oil, and eucalyptus oil.

Examples of the anti-inflammatory agent include allantoin, glycyrrhetinic acid salt, glycyrrhetin derivative, tranexamic acid, and azulene, but are not limited thereto.

The cosmetic ingredient may be a whitening agent such as arbutin, glutathione and sucky extract, a cell activator such as a royal jelly, a cholesterol derivative and a baby calf blood extract, a nicotinic acid benzyl ester, nicotinic acid? -Butoxyethyl ester, capsaicin, A blood circulation accelerator such as cantharides tincture, icatamol, caffeine, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinarnizine, tolazoline, verapamil, A skin astringent, and the like may be used, but the present invention is not limited thereto.

The vitamin components include vitamin A such as vitamin A oil, retinol, retinol acetate and retinol palmitate, vitamin B2 such as riboflavin, riboflavin butyrate, and flavin adenine nucleotide, vitamins such as pyridoxine hydrochloride and pyridoxine dioctanoate Ascorbic acid dibasic acid ester, L-ascorbic acid-2-sulphate, DL-a-tocopherol-L-ascorbic acid diester diacid, etc .; vitamin C such as pantothenic acid Pantothenic acid such as calcium, D-pantothenyl alcohol, pantothenyl ethyl ether and acetyl pantothenyl ethyl ether, vitamin D such as ergocalciferol and cholecalciferol, nicotinic acid such as nicotinic acid benzyl, nicotinic acid amide, Vitamin E such as DL-alpha -tocopherol, DL-alpha -tocopherol acetic acid, DL-alpha -tocopherol nicotinic acid DL-alpha -tocopherol and succinic acid DL- alpha -tocopherol, vitamin P and biotin However, it is not limited thereto.

The pharmaceutical composition according to the present invention may be formulated into oral or parenteral dosage forms in the form of solid, semi-solid or liquid, by adding a known inorganic or organic carrier. Examples of the agent for oral administration include tablets, pills, granules, capsules, powders, and pellets. Examples of the parenteral administration agent include injections, drops, ointments, creams, lotions, sprays, suspensions, emulsions, suppositories, etc., and various pharmacological agents such as bandages, bandages, Patch, and the like, but the present invention is not limited thereto.

The cosmetic composition containing the composition according to the present invention can be used as a skin care cosmetic such as toner, lotion, cream, essence and lotion used in various cosmetic packs, foundation, concealer, makeup base, blusher, Makeup cosmetics such as a shadow, an eyeliner, a lipstick, and an ultraviolet screening cosmetic, but are not limited thereto.

When the pharmacological or cosmetic composition of the present invention is applied, it is possible to maintain the emulsified state stably without lecithin, which is one kind of natural emulsifier, which is a kind of natural emulsifier, besides lecithin, Or a cosmetic may be provided.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate preferred embodiments of the invention and, together with the description of the invention given above, serve to further the understanding of the technical idea of the invention, It should not be construed as limited.
Fig. 1 is a graph showing a result of evaluating the feeling according to the first embodiment of the present invention.

Hereinafter, test examples and examples will be described in detail to facilitate understanding of the present invention. However, the test examples and examples according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following examples. Embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art to which the present invention belongs.

Table 1 shows the compositions and the weights thereof in one embodiment in the preparation of an underwater type cosmetic preparation according to the present invention. However, the compositions and weights shown in the embodiments described herein are merely preferred embodiments and are not intended to represent all of the technical ideas of the present invention, so that various equivalents It should be understood that water and variations may be present.

[Confirmation of emulsified state of cosmetic composition to which the present invention is applied and stability evaluation]

Example  1-3 and Comparative Example  Preparation of 1-6

An underwater type cosmetic composition was prepared using ingredients and weights as shown in Table 1 below. To confirm the improved stability of the emulsified state obtained by mixing the viscous ester oil in the cosmetic composition containing lecithin as an emulsifier A comparative evaluation was conducted. The lecithin used in the test was hydrogenated lecithin, Examples 1-3 were prepared to include lecithin and high viscosity ester oil, and Comparative Examples 1-6 were prepared to include lecithin and low viscosity ester oil.

ingredient
(weight%) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 One Hydrogenated lecithin 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 2 Dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate 3.0 - - - - - - - - 3 Bis-diglyceryl polyacyl adipate-2 - 3.0 - - - - - - - 4 Cholesteryl hydroxystearate - - 3.0 - - - - - - 5 Cetyl ethyl hexanoate - - - - 3.0 - - - - 6 Isocetyl myristate - - - - - 3.0 - - - 7 Octyldodecyl myristate - - - - - - 3.0 - - 8 Pentaerythrityl tetraethyl hexanoate - - - - - - - 3.0 - 9 Polyglyceryl-2 triisostearate - - - - - - - - 3.0 10 Squalane 20.0 20.0 20.0 20.0 20.0 20.0 20.0 20.0 20.0 11 Carbomer 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 12 Tromethamine Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 13 Dipropylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 14 glycerin 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 15 Propanediol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 16 Phenoxyethanol Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 17 water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100

Observation of emulsion condition and evaluation of stability

The emulsified state immediately after preparation of Example 1-3 and Comparative Example 1-6 were compared and sampled (sampled) for each of Example 1-3 and Comparative Example 1-6, which were prepared in order to confirm the stability of the formulation, Respectively. The two samples were then stored at 45 ° C and 0 ° C, respectively, for one month from the date of manufacture, and the other sample was repeatedly subjected to 5 cold washes. The emulsion state immediately after preparation and the stability of the formulations on the three samples treated with the respective conditions were visually observed, and the evaluation results according to the following evaluation criteria are shown in Table 2.

Compare Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Immediately after manufacture
Emulsified state ○ ○ ○ X X X X X △ 45 ° C Storage stability ○ ○ △ X X X X X X 0 ° C Storage stability ○ ○ ○ X X X X X X Stability after 5 cycles of cold-freezing ○ ○ ○ X X X X X X

<Evaluation Criteria>

No phase separation observed: ○

Partially heterogeneous emulsification was observed:

Complete phase separation was observed: X

As can be seen from the above Table 2, the cosmetic compositions using lecithin as an emulsifier were superior in the emulsified state immediately after preparation, as compared with Comparative Example 1-6, , Storage stability at 45 [deg.] C and 0 [deg.] C for one month, and stability of the formulation after 5 cycles of cold rinsing.

[Evaluation of stability according to content of lecithin and high viscosity ester oil]

Preparation of Example 4-6

A water-in-oil cosmetic composition was prepared using ingredients and weights as shown in Table 3 below. In order to confirm a desirable blending ratio (weight ratio) of the two components in a cosmetic composition comprising lecithin and a high viscosity ester oil, lecithin And a high viscosity ester oil. The lecithin used in the test was hydrogenated lecithin and dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate was used as the high viscosity ester oil. The weight ratio of lecithin and high viscosity ester oil was hydrogenated lecithin: dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognetate, Example 4 was 1: 100, Example 5 was 1: 2, and Example 6 Was prepared at 1: 0.56.

Component (% by weight) Example 4 Example 5 Example 6 One Hydrogenated lecithin 0.20 5.00 9.00 2 Dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate 20.00 10.00 5.00 3 Squalane 10.00 10.00 10.00 4 Carbomer 0.05 0.05 0.05 5 Tromethamine Suitable amount Suitable amount Suitable amount 6 Dipropylene glycol 5.00 5.00 5.00 7 glycerin 5.00 5.00 5.00 8 Propanediol 5.00 5.00 5.00 9 Phenoxyethanol Suitable amount Suitable amount Suitable amount 10 water To 100 To 100 To 100

Observation and stability evaluation of emulsification according to the contents of both components

The emulsified state immediately after preparation was compared, and samples (samples were taken) were prepared for each of Examples 4-6 prepared for confirming the stability of the formulation. The two samples were then stored at 45 ° C and 0 ° C, respectively, for one month from the date of manufacture, and the other sample was repeatedly subjected to 5 cold washes. The emulsified state immediately after preparation and the stability of the formulations on the three samples treated with the respective conditions were visually observed, and the evaluation results according to the following evaluation criteria are shown in Table 4.

Compare Example 4 Example 5 Example 6 Immediately after manufacture
Emulsified state ○ ○ ○ 45 ° C Storage stability ○ ○ ○ 0 ° C Storage stability ○ ○ ○ Stability after 5 cycles of cold-freezing ○ ○ △

<Evaluation Criteria>

No phase separation observed: ○

Partially heterogeneous emulsification was observed:

Complete phase separation was observed: X

As shown in Table 4, in Example 6 in which the weight ratio of lecithin and high viscosity ester oil was 1: 0.56, a partially uneven emulsified state was observed after 5 repetitions of the cold deterioration. However, C and 0 ° C after storage for one month. In the case of Example 4-5 in which the weight ratios were 1: 100 and 1: 2, respectively, it was confirmed that the stability of the formulation immediately after preparation and after the treatment of each condition was still stable.

[ Evaluation of use feeling and result]

The feeling of use was evaluated by applying Example 1 to the facial skin of 23 women aged 20-30. The evaluation items were a feeling of tingling, an absorbency, a moistness, a skin texture, and a feeling of nourishment, and evaluated according to the following evaluation criteria.

<Evaluation Criteria>

Poor: 1

Poor: 2

Moderate: 3

Good: 4

Very Good: 5

The evaluation results are shown in Fig. As can be seen from Fig. 1, a feeling of use evaluation was conducted for women in their 20s and 30s who used the cosmetic composition of Example 1 for facial skin, and as a result, all the evaluation items showed an excellent evaluation of 4.0 or more. Particularly, it was confirmed that 4.3 or higher evaluation was shown in the evaluation of the feeling of dullness and moisture.

Claims (11)

In a composition comprising lecithin as an emulsifier or a surfactant,
And a high viscosity ester oil. The lecithin emulsifying composition according to claim 1, wherein the lecithin emulsifying composition is an oil in water type. The lecithin emulsifying composition according to claim 1, wherein the lecithin emulsifying composition is a pharmaceutical composition. The lecithin emulsifying composition according to claim 1, wherein the lecithin emulsifying composition is a cosmetic composition. The lecithin emulsification composition according to claim 1, wherein the lecithin is at least one selected from the group consisting of natural phospholipids, synthetic lecithin, and hydrogenated lecithin. The lecithin emulsification composition according to claim 1, wherein the high viscosity ester oil represents a paste or a wax phase. The lecithin emulsification composition according to claim 1, wherein the high viscosity ester oil is an adipate or a fatty acid ester. The composition of claim 1, wherein the high viscosity ester oil is selected from the group consisting of dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate, bis-diglyceryl polyacyl adipate-2, cholesteryl hydroxystearate, Polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, / Tetrastearate / tetraisostearate, glyceryl ethylhexanoate / stearate / adipate, caprylic / capric / myristic / stearic triglyceride, hydrogene palm oil and petrolatum And at least one selected from the group consisting of a lecithin emulsifying tank Water. The lecithin emulsification composition according to claim 1, wherein the high viscosity ester oil is an ester oil having a weight average molecular weight of 550 or more. [3] The composition according to claim 1, wherein the content of the lecithin is 0.01 to 20% by weight based on the total weight of the composition, and the content of the high-viscosity ester oil is 0.01 to 40% by weight based on the total weight of the composition. The lecithin emulsification composition according to claim 1, wherein the weight ratio of the lecithin to the high viscosity ester oil is 1: 0.2 to 1: 150 as lecithin: high viscosity ester oil.

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