KR20160062401A - Cosmetic composition having Anti-aging and anti-wrinkle effect containing wheat sprout extracts - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising, as an active ingredient, an extractive mixture obtained by mixing extracts of green tea, camphor tree, Halla pertussis, Jeju borsaetiflora, and ganoderma lucidum fruit.
The cosmetic composition for wrinkle improvement according to the present invention is expected to be highly suitable for wrinkle-improving skin care, since it exhibits improved safety to skin and excellent collagen synthesis promoting effect, and therefore has excellent durability of skin wrinkle improving effect.

Description

[0001] Cosmetic composition having anti-aging and anti-wrinkle effect containing wheat sprout extracts [

The present invention relates to a cosmetic composition for improving skin wrinkles, and more particularly, to a cosmetic composition for improving skin wrinkles containing a ginseng extract.

In general, skin wrinkles are known to be produced by various factors such as moisture content of skin, collagen content, immunity to external environment, and especially, 70% Of the collagen fibers is reduced by aging, or the collagen fibers are deformed by the external environment, so that a lot of wrinkles are generated and deepened on the skin.

Conventionally, in order to improve the wrinkles of the skin, the composition has been provided as a cosmetic composition for suppressing transdermal water evaporation, a collagen for providing skin elasticity, and the like. In recent years, herbal medicines have been used for moisturizing, anti- And the use of herbal medicines has become prominent in the field of cosmetics, and many studies have been conducted on cosmetic compositions using herbal medicine extracts. In addition, researches on the cosmetic compositions using extracts isolated from natural products Background Art [0002] Various prior arts relating to the anti-aging and cosmetic composition for improving wrinkles have been known.

And wheat (Triticum aestrivum) is the first crop in the world to be grown in the temperate zone. It has been used for precious wheat food in Korea since ancient times, and wheat has a little temper, It is known that it eliminates burning, reduces thirst, supports diuretic action and the interphase. Recently, it is a trend to use germinated wheat and whole wheat as health functional food, and shows great interest in its efficacy.

Especially, wheat contains high content of proteins, vitamins and chlorophyll compared with whole wheat. It is rich in vitamin C superoxide dismutase (SOD) enzyme which has 6 times as much as mandarin orange and antioxidant power, and wheat bran is mucolytic acid crystal It is known that it eliminates toxins in the body by eliminating succulence, and is strong in antioxidant power and has excellent effects such as cancer, hypertension, diabetes, and atopy.

For example, in Korean Patent Registration No. 10-1250386, 20% by weight of broccoli, 20% by weight of alfalfa, 20% by weight of cabbage, 20% by weight of sprout wheat 15% by weight, a mixture of 10% by weight of blueberry seeds and 15% by weight of unsweetened seeds by hot water extraction at 100 ° C for 9 hours, followed by ultrasonic extraction at 50 ° C for 1 hour, And a cosmetic composition for accelerating the removal of keratin, black spot, freckles, or the like, which comprises an extract of a myrrh 2 and an extract of a myrrh, as an active ingredient, is disclosed in Korean Patent Registration No. 10-1303294 And Korean Patent Publication No. 10-1363029 discloses that the extracts of Mugwort, marigold, moss, and bergamot By weight, respectively, in a weight ratio of 1: 10: 1 to 10: 1 to 10: 1: 10.

The present invention confirms that a cosmetic composition comprising an extract of a mildew plant together with an extract of a mildew with excellent antioxidant power exhibits a superior skin wrinkle-reducing effect, and completed the present invention.

The present invention relates to a cosmetic composition for improving skin wrinkles using a mixture of a green tea extract and a natural plant extract. More specifically, the present invention relates to a cosmetic composition for improving skin wrinkles, comprising a mixture of a green tea extract, a camphor tea extract, The present invention aims to provide a cosmetic composition for wrinkle-improving skin wrinkle improvement which is excellent in wrinkle-improving skin care and which complements the safety of a wrinkle-improving skin care component commonly used in the conventional cosmetic industry.

As a solution to achieve the object of the present invention, the cosmetic composition for improving skin wrinkles containing the extract of wheat comprises 15-20 parts by weight of a camphor leaf extract, 15-20 parts by weight of a Halla herb extract, 15 to 20 parts by weight of a Sasa extract, and 15 to 20 parts by weight of an extract of Pisum sativum, in an amount of 0.01 to 15% by weight based on the total weight of the cosmetic composition.

The wheat contains protein (protein 23 g / 100 g of wheat), vitamins at a higher ratio than whole wheat, vitamin C 6 times as much as mandarin and especially 543 mg of chlorophyll called "natural red blood" The superoxide dismutase (SOD) enzyme, which has antioxidant power in wheat, is not contained in whole wheat flour. It has excellent antioxidant ability and has strong antioxidant ability. It has effects such as cancer, hypertension, diabetes and atopy Is known to be excellent.

In the present invention, the extract is obtained by extracting the above-mentioned germ from alcohol at room temperature, specifically with ethanol. In order to increase the extraction efficiency, it is preferable to pulverize and dry the dried germ.

The camphor leaves are useful for disinfection of inflammation by fumigation. The camphor leaf extract reduces the expression of TNF-α, IL-6 and IL-1β, which are inflammatory mediators, and the elimination of DPPH and xanthine oxidase-hypoxanthine It is known to be effective for anti-inflammation and antioxidation.

The above-mentioned Halla vulgaris is a plant of Asteraceae which grows at 1,300m above sea level in Jeju Island, Jeju Island, and has been dried for a long time after having dried the leaves and stalks of Rhizobium japonica in menstrual irregularities, poor circulation, infertility, . It grows in a clean area and is also known to be effective for antibacterial, anti-inflammatory and skin eczema. The Jeju berry bred grows in Halla Mountain, Jeju Island. It releases heat and releases toxins and is effective against cancer cell suppression, diabetes, hypertension, gastritis and stomach cancer. do. It is used as a representative natural cosmetics raw material of Jeju Island and it is known that it is excellent for skin whitening function and collagen synthesis.

In addition, the above-mentioned pomegranate fruit is called as a pomegranate, and it is useful for headache, eye disease, ear infections, etc. The extract of Pomegranate fruit contains essential oil such as Kempene, , And is excellent in antiallergic action and is often used as a cosmetic composition.

Also, it is preferable to use an extract obtained by extracting with alcohol at room temperature the camphor tree, Halla transplant, Jeju berry bran, and Porphyra japonica, which are dried and pulverized to enhance extraction efficiency.

The mixture of the extracts of the wheat germ extract is mixed with 100 parts by weight of the extract to 15-20 parts by weight of the camphor leaf extract. 15 to 20 parts by weight of a Halla Orthoptera extract, 15 to 20 parts by weight of an extract of Jeju Sasa basil, and 15 to 20 parts by weight of an extract of Pepper fruit.

The steam-extract mixture according to the present invention may be prepared by taking into account the stability and palatability of the formulation 0.01 to 15% by weight based on the total weight of the cosmetic composition. If the amount is less than 0.01% by weight, the effect / effect is insufficient. If the amount is more than 15% by weight, the stability of the formulation is poor. And is preferably 0.1 to 10% by weight based on the total weight of the cosmetic composition.

The cosmetic composition containing the germ extract mixture according to the present invention is prepared according to a conventional method for producing a cosmetic. For example, it may be combined with a pharmaceutically or dermatologically acceptable excipient such as a lotion, cream, essence, cosmetic lotion, spray, cleansing foam, cleansing water, pack, body oil, lotion, foundation, lipstick, mascara, , Make-up remover, and detergent, and the excipient may include a pharmacologically or dermatologically acceptable skin softening agent, a skin permeation enhancer, a coloring agent, a fragrance, an emulsifier, a thickener, and a solvent.

The cosmetic composition for improving skin wrinkles using the germ extract mixture according to the present invention has an effect of improving the stability to the skin by using the extract of the wheat extract and the extract of the natural plant in combination, and exhibiting an excellent effect on the improvement of the skin wrinkles.

EXAMPLES Hereinafter, the present invention will be described in detail with reference to Examples and Test Examples. However, the present invention is not limited to the following examples.

<Examples>

 One). Wheat Extract Manufacture

To 200 g of the wheat powder obtained by pulverizing the dried germ, 10 L of 80% EtOH was added and extracted four times at room temperature for 72 hours. The extract was filtered through a filter paper, and the filtrate was concentrated under reduced pressure to obtain 128.65 g of an ethyl acetate extract (yield: 64.33%).

In the same manner as the above-mentioned wheat extract, camphor tree, Halla herbaceousum, Jeju borsaetiflora, and Porphyra japonica were individually extracted and 100 g of each extract was prepared.

 2). Manufacture of wheat extract mixture

Each of the extracts obtained above was uniformly mixed with 60% by weight of the extract, 10% by weight of camphor leaf extract, 10% by weight of Halla herbacea extract, 10% by weight of Jeju berry berry extract and 10% Mixed solution.

For the accuracy of the experiment, 250 μg / ml, 100 (w / w) extract of wheat germ extract and WS extract obtained from the above <Experimental Example> (WS) diluted to a concentration of 50 μg / ml, and a mixture of wheat extract diluted with 250 μg / ml, 100 μg / ml and 50 μg / ml.

Test Example 1 DPPH radical scavenging activity

In this experiment, the antioxidant activity of Blois (Blois, 1958) was modified to measure the radical scavenging activity of the sample.

800 μl of 0.1 mM DPPH (2,2-diphenyl-1-picrylhydrazyl, Sigma, USA) dissolved in 95% ethanol and 200 μl of each experimental group were placed in an E.P tube and reacted for 30 minutes in a dark room by vortexing for 3 minutes.

The concentration of residual radicals was measured at 517 nm using a UV-Visible spectrophotometer (SCINCO, Seoul, Korea), and gallic acid (Sigma, USA) was used as a positive control. The concentration range was 100 μg / / Ml. The scavenging ability (IC ₅₀ ) of the extract against DPPH was expressed as the concentration required to reduce the absorbance of the control using only the solvent by 50%.

The results [Table _{1] (IC 50 of radical scavenging} activity) IC of the wheat germ extract (WS) and wheat germ extract liquid mixture, as shown in ₅₀ (㎍ / ㎖) and 86.31 (㎍ / ㎖), respectively. Antioxidative activity of gallic acid was lower than that of gallic acid. However, .

&Lt; Test Example 2 > ABTS radical scavenging activity

In this experiment, Jeong et al. (2009) was modified and measured. The solution was diluted with PBS (pH 7.4) so that the absorbance value was 0.70 ± 0.02 by adding 1: 1 ABTS potassium persulfate (2.45 mM) dissolved in distilled water.

After incubation for 12 ~ 16 hours, the radial stock solution was added to the diluted solution (800 ㎕) of each sample (200 ㎕) and the absorbance was measured for 15 minutes. Gallic acid (Sigma, USA) was used as a positive control and the concentration range was 0.1 ~ 0.025 mg / ㎖.

The abstraction (IC ₅₀ ) of the extracts against ABTS was expressed as the concentration required to reduce the absorbance of the control using only solvent by 50%. The experimental results showed a higher antioxidant activity than the DPPH radical scavenging activity, the results were determined as because the ABTS radical scavenging ability measurement method can measure both hydrophilic and hydrophobic materials, wheat germ extract (WS) and the IC ₅₀ of a wheat germ extract mixture The values were 63.50 (㎍ / ml) and 68.18 (㎍ / ml), respectively, as shown in Table 1 below (IC ₅₀ of radical scavenging activity).

&Lt; Test Example 3 > SOD activity

The reaction conditions were as follows: 1 ml of WST solution was mixed with 19 ml of Buffer solution, and 15 μl of enzyme solution (xanthine) was mixed with 25 ml of dilution buffer to prepare a reaction solution.

As shown in Table 1, the IC ₅₀ values of the SOD ridical cleavage of the extracts of wheat germ extract and wheat germ extract were 89.31 and 93.73 ㎍ / ㎖, respectively, as shown in Table 1 (IC ₅₀ of radical scavenging activity) Showed high antioxidant activity, which is consistent with the two previous methods (DPPH, ABTS).

Test Example 4 Measurement of Hydroxyl Radical Cancellation Effect

Hydroxyl radicals are the most chemically reactive radicals in the active oxygen radicals. They are known to initiate lipid oxidation and cause DNA damage or mutagenesis. The lipid peroxides or hydrogen peroxide produced in the metabolism of the body are either Fe ²⁺ or Cu ^It is the most toxic free radical produced in the presence of ²⁺ ions.

As shown in Table 1 below, the IC ₅₀ values of the mixture of the extract of wheat germ and the extract of wheat germ were 84.81 (㎍ / ㎖) and 86.50 (㎍ / ㎖), respectively, as shown in the IC ₅₀ of radical scavenging activity Antioxidant assay methods (DPPH, ABTS, SOD).

According to the results of the above experiment, the IC ₅₀ average values of each of the mixture of the extract of wheat germ and the extract of the wheat germ were estimated to be 80 (㎍ / ㎖) and 84 (㎍ / ㎖), respectively. These antioxidant activities are thought to be caused by flavonoids and polyphenols. It is necessary to identify the antioxidant ability and precise mechanism by using the standard materials of each ingredient. When the results of the antioxidant ability tests are taken into consideration, the whey extract mixture according to the present invention is superior to the extract of wheat germ, It is judged that it is very suitable as a material.

Example 2 Cosmetic formulation

Nutritional creams were prepared according to the composition and composition ratios shown in [Table 2] below. [Table 2] < Formulation Example; Nutrition Cream &quot; is an example for helping understanding of the present invention, and the present invention is not limited to the following formulation examples.

INCI Name Amount (wt%) Remarks Glycerin 5.00 Allantoin 0.10 Dipotassium glycyrrhizate 0.10 Propanediol 5.00 Sparassis crispa extract 1.50 Lactobacillus / Soymilk ferment extract 1.00 Hydrogenated lecithin 1.00 Grated extract mixture 1.00 Xanthan gum 0.10 Bentonite 0.40 Cetearyl alcohol 1.50 Glyceryl stearate, PEG-100 stearate 1.00 Simmondsia chinensis (Jojoba) seed oil 1.00 Macadamia ternifolia seed oil 1.00 Butyrospermum parkii (Shea butter) 1.00 Cetearyl olivate, Sorbitan olivate 3.00 Tocopheryl acetate 0.40 Dimethicone 1.00 Caprylhydroxamic acid, Caprylyl glycol, Glycerin 0.50 Phenoxyethanol 0.30 Water to 100.00

The cosmetic composition of the present invention can be blended with an ordinary ingredient to be incorporated in a cosmetic composition for general skin. The oil component content of the cosmetic composition according to the present invention is selected in consideration of enhancement of emulsifying ability and economical efficiency, and at least one oil selected from vegetable oil, mineral oil, silicone oil and synthetic oil can be used . In addition, 0.1 to 5% by weight of a surfactant, a higher alcohol and the like may be added to reinforce the emulsifying ability. As such surfactants, conventional surfactants such as nonionic surfactants, phospholipids and the like can be used. As the higher alcohols, alcohols having 12 to 20 carbon atoms can be used singly or in combination. In addition, in the cosmetic composition, 0.001 to 5% by weight of one or more kinds of thickening agents such as carbomer, xanthan gum, bentonite and the like may be further added in order to control the viscosity or hardness of the water phase. In addition, the composition of the present invention may further contain a pharmaceutical ingredient such as higher fatty acids and vitamins, and components used in conventional cosmetics such as an ultraviolet screening agent, an antioxidant, a preservative, a flavoring agent, a coloring agent, and a pH adjusting agent. The cosmetic composition of the present invention is a product which is absorbed through the skin, and is a product which can be used as a skin care cosmetic composition for a cosmetic composition, such as a soft longevity (skin), a convergent lotion, a nutritional lotion (lotion), a nutrition cream, a massage cream, an essence, a gel, a pack, Suspension, emulsion, spray, or serum, and may contain various conventional carriers and additives suitable for each of these formulations and known in the art. While the present invention has been described with reference to certain preferred embodiments, it is to be understood that the invention is not limited to the disclosed embodiments.

&Lt; Test Example 4 > Stability test of cosmetic formulation

The above formulation was subjected to a long-term storage test (temperature: 25 ± 2 ° C / relative humidity: 60 ± 5%), an accelerated test (temperature: 40 ± 2 ° C / relative humidity: 75 ± 5% : 40 ℃, 8hrs → 20 ℃, 8hrs → 0 ℃, 8hrs). The test was conducted for 6 months for the long-term storage test, 3 months for the accelerated test and 1 month or more for the severe test. No physico-chemical changes were observed and it was confirmed that the formulation had a very stable formulation.

Claims (4)

A mixture of 15 to 20 parts by weight of a camphor leaf extract, 15 to 20 parts by weight of a Halla herbaceutic extract, 15 to 20 parts by weight of an extract of Jeju bamboo sake bran, and 15 to 20 parts by weight of an extract of Pseudomonas sp. Is contained in an amount of 0.01 to 15% by weight based on the total weight of the cosmetic composition. The method according to claim 1,
Characterized in that the mixture of the extract of Liliaceae is composed of 60% by weight of the extract, 10% by weight of camphor leaf extract, 10% by weight of Halla herbacea extract, 10% by weight of Jeju berry berry extract and 10% A cosmetic composition for improving skin wrinkles. The method according to claim 1 or 2,
A cosmetic composition for improving skin wrinkles containing a extract of a wheat germ extract, wherein the germ extract mixture contains 0.1 to 10% by weight based on the total weight of the cosmetic composition. The method of claim 3,
The cosmetic composition can be used in cosmetics such as soft longevity (skin), astringent lotion, nutritional lotion (lotion), nutritional cream, massage cream, essence, gel, pack, powder, ointment for external use, suspension, emulsion, spray, shampoo, Wherein the cosmetic composition is a cosmetic composition for improving skin wrinkles.