KR20140043930A - Wipe for application of at least one active principle on the skin - Google Patents

Abstract

The present invention, inert plate-like support; A plurality of microcapsules containing one or more active ingredients and applied to an inert plate-like support; And at least one surfactant applied to the inert plate-like support, to a dry wiper for applying at least one active ingredient on the skin.

Description

WIPE FOR APPLICATION OF ONE OR MORE ACTIVE ACTIVE ON THE SKIN {WIPE FOR APPLICATION OF AT LEAST ONE ACTIVE PRINCIPLE ON THE SKIN}

The present disclosure relates to a wiper for applying an active principle, preferably a cosmetic active ingredient, on the skin. In particular, the present disclosure relates to a wiper in the form of a cotton wool sheet for applying a cosmetic active ingredient on the skin.

Known skin care wipers are wet wipers, ie wipers impregnated with the active ingredient for skin treatment in liquid form or dissolved in the solvent phase.

Such wipers should be packaged in a sealed package to prevent evaporation of the liquid phase and use over time. Wipers can be packaged in single or multiple packages; In the first case, the package must be sealed at the time of factory production, while in the second case, the package is sealed and sealed in a manner that ensures that the humidity in the wiper is preserved for use of the wiper over time. It must be suitable for resealing.

However, such packages are very often not properly sealed or unable to maintain the required seals, resulting in dry and unusable wipers from the package when used by the user.

Thus, there is a need for the development of wipers that do not require such special packaging.

In view of this premise, there is no need to be packaged in a hermetically sealed package, and there is a need for a solution that enables the realization of a wiper for applying an active ingredient, preferably but not necessarily, cosmetic active ingredients on the skin. .

According to the present invention, the above object is achieved by a solution specifically set forth in the appended claims, which constitute an essential part of the present specification.

One embodiment of the invention relates to a dry wiper for the application of an active ingredient, preferably cosmetics, on the skin, the active ingredient being contained in a microcapsule applied on the surface of the wiper, the wiper being one It contains the above surfactant.

Particularly preferred embodiments relate to dry wipers for the application of active ingredients on the skin, said wipers containing an inert plate-like support, preferably a cotton wool nonwoven sheet, at least one active ingredient, preferably a lipophilic ingredient. A plurality of microcapsules, and at least one surfactant, are applied to the surface of the plate-like support.

In the following specification, numerous specific details are set forth in order to provide a thorough understanding of the embodiments. Embodiments may be practiced without one or more specific details, or by other methods, components, materials, and the like. In other instances, well known structures, materials, or manipulations are not shown in detail or described in order to avoid obscuring certain aspects of the embodiments.

Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure, or characteristic described in connection with the embodiment is included in one or more embodiments. Thus, the phrases “in one embodiment” or “in an embodiment” in many parts throughout this specification are not necessarily all referring to the same embodiment. In addition, the details of features, structures, or properties may be combined in any suitable manner in one or more embodiments.

The headings provided herein are for convenience only and should not be construed in the scope or meaning of the embodiments.

As mentioned above, the present invention does not need to be hermetically sealed and packaged in order to preserve the function of the wiper itself, i.e. the required humidity, and is an active ingredient on the skin, preferably but not necessarily a cosmetic active ingredient. The purpose of the development of the wiper is to apply.

One embodiment of the invention relates to a dry wiper for applying at least one active ingredient on the skin, wherein the at least one active ingredient is contained in a microcapsule applied on the surface of the wiper, the wiper being at least one The above surfactant is contained / absorbed.

The expression "dry wiper" refers to a wiper having a moisture content of 7%, preferably 5% or less.

The wiper object herein applies a reduced amount of moisture wiper in use and rubs the wiper over the skin to allow the active ingredient to be applied on the skin (by the user).

Thus, rubbing on the skin exerts a pressure that can break the microcapsules, resulting in the leakage of the active ingredient (usually lipophilic), which is then quenched by the surfactant contained in the wiper Added at the time of use). Therefore, the oil-in-water (O / W) emulsion formed can exert its functions, for example, washing, moisturizing, etc., on the skin.

Particularly preferred embodiments relate to the use of lipophilic cosmetically active ingredients which can be emulsified during the application step.

In a further embodiment, the microcapsules also contain a fragrance which is released upon crushing to allow the user to sense the activation of the microcapsules, ie the release of the active ingredient.

Thus, in a preferred embodiment, the wiper object herein consists of an inert plate-like support in the form of a woven or nonwoven sheet and the following applies:

i) temperature stable surfactants;

ii) a plurality of microcapsules containing the active ingredient (s), preferably lipophilic, and optionally fragrances (also preferably lipophilic).

Also in a particularly preferred embodiment, a film-forming agent is applied to the inert plate-like support, which film-forming agent can produce a film that captures and retains microcapsules on the support itself.

In a preferred embodiment, the wiper consists of a sheet nonwoven, a synthetic material (eg polyester), or a mixture sheet thereof, more preferably a cotton wool sheet, having a reduced moisture content. Also in a more preferred embodiment, the wiper consists of a layer of water-needled cotton wool nonwoven. Wipers may be made of natural or various colors (including white) or combinations thereof.

Examples of lipophilic cosmetic active ingredients applicable to the wiper objects herein include mallow, chamomile, anise, fennel, carrot, aloe, orange, bamboo, marigold, fig, ginseng, St. John's wort, lavender, lemon, mandarin, apple Oil- or triglyceride extracts of orchid, pine, tomato, propolis, rosemary, red grapes, vanilla; Cashew, Argan, Avocado, Babasu, Borage, Cocoa, Carrot, Cherry, Coconut, Canola, Cotton, Malt, Jojoba, Flaxseed, Macadamia Nut, Walnut Husk, Almond, Indian Mulberry, Hazelnut, Olive There are oils of palm trees, pine trees, grape seeds, pistachios, musk roses.

Preferably, the microcapsules used in the present invention consist of a polyurethane polymer that is acceptable for the process of making the wiper. In particular, the microcapsules must be able to withstand the drying and packaging processes required for the realization of dry wipers without deterioration. In either case, microcapsules composed of polyamide- or polyacrylate-based polymer membranes may be used.

Examples of polyurethane polymers usable in the present invention include bifunctional, trifunctional hydroxyl compounds and / or difunctional amine compounds, in particular ethylene glycol, diethylene glycol, propylene glycol, tetraethylene glycol, tripropylene glycol, 1,3- Propanediol, 1,4-butanediol, neopentyl glycol, 1,6-hexanediol, 1,4-cyclohexanedimethanol, ethanolamine, methyldiethanolamine, phenyl diethanolamine, diethanolamine, glycerol, trimethylol 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, 4,4-diphenylmethane with propane, 1,2,6-hexanetriol, triethanolamine, diethyltoluenediamine, dimethylthiotoluenediamine Diisocyanate, 2,4-diphenylmethane diisocyanate, isophorone diisocyanate, copolymers of methylene bis 4-cyclohexyl diisocyanate, and homopolymers.

Polyurethane polymers are synthesized from isocyanates, the isocyanates having, as their main features, highly reactive isocyanate groups —NCO with active hydrogen-containing groups and together form a stable urethane compound through exothermic reactions. Among the various isocyanates, preferred compounds include toluene diisocyanate (TDI), especially 2,4-toluene diisocyanate, which is more reactive than 2,6-isomer. The order of the reaction of the compound containing active hydrogen with the aromatic isocyanate is as follows: aliphatic amine> aromatic amine> primary hydroxyl> secondary hydroxyl> water> carboxylic acid = urea> urethane.

Microencapsulation is a known technique in the pharmaceutical, cosmetic, agricultural and food industries. Microencapsulation is realized through chemical and physics techniques such as emulsions, coacervation and interfacial polymerization techniques (chemical processes), spray-drying techniques, spray cooling and fluid bed coating (physical processes).

Polyurethane-based microcapsules are preferably prepared by interfacial polymerization techniques; Microcapsules based on polyamides can be obtained by solvent spray-drying techniques, while polyacrylate-based microcapsules can also be prepared using emulsion techniques.

The wiper and its industrial manufacturing steps are in accordance with specification CEN / TR15917: 2009, which is an inert to preserve cosmetic active ingredients during the manufacturing, packaging, transport and storage phases as well as the release of cosmetic active ingredients over time. It defines a cosmetotextile as a fabric substrate.

An embodiment of a wiper according to the present specification will now be provided by way of non-limiting example. In particular, in the context of the present specification, we provide specific examples for interfacial polymerization, because interfacial polymerization is particularly advantageous for the coating / encapsulation of lipophilic active ingredients by polyurethane polymers.

Materials and methods

A) Preparation of Cotton Wool (Inert Fabric Substrate) CEN / TR15917 : 2009):

Cotton wool is a material of plant origin (in the raw state) and is in the form of a bundle of fiber filaments having a chemical composition as shown in Table 1 below.

Thus, the proportion of impurities (e.g. fats and waxes, pectin and lignin, minerals and organic acids) is very high, imparting lipophilic properties to the fibers, which are achieved through chemical processes of washing and sterilization known in the textile arts. Removed.

The raw cotton was then treated in an autoclave at 100 ° C. at a pressure of 3.5 bar for 1 hour as follows:

i) Washing with a solution as shown in Table 2 below at a cotton: crude ratio of 1:10.

ii) three rinses with water:

Time = 10 minutes; Temperature = 40 ° C., pressure = 3.5 bar.

The product obtained is a white bundle of hydrophilic fibers and conforms to the European Pharmacopoeia (cotton cotton).

B) of cotton wool Nonwoven fabric  Preparation of Sheets (Inert Fabric Substrate)

The resulting cotton ball bundles were carded.

Carding is a process known in the textile art and consists of opening, separating and cleaning the fiber mass and partial straightening thereof.

The carding machine consists of two or more large rollers with metal teeth; In a subsequent step, the spacing between the rollers was reduced to produce a thin fiber membrane with a certain parallelism.

The resulting fiber membranes were woven with very high pressure jet of water (also known as water-needling) and air dried in an oven at 100 ° C to 150 ° C.

The sheet obtained was then cut into strips of various sizes.

C) Lipophilic  Preparation of Polyurethane-Based Microcapsules Containing Cosmetic Active Ingredients

Microcapsules are prepared by the following known organic synthesis techniques for the preparation of polyurethane-derived prepolymers by reaction of diisocyanates with polyols.

The preliminary step dissolves dimethylphenyl diisocyanate (MDI) or toluene diisocyanate (TDI) in cyclohexanone, heats the monomer to 80 ° C. and adds a derivative of a polyol such as polyethylene glycol, polypropylene glycol or glycerin. Consisting of slowly adding at a molar concentration of 3: 1 for time.

The reaction of glycerin (1) with toluene diisocyanate (3) and the resulting polyurethane prepolymer (4) are schematically illustrated below.

30 ml of deionized water and 4.5 g of gum arabic are then mixed in a beaker at room temperature; The aqueous solution was stirred for 2 hours using a blade mixer.

A small amount of catalyst, for example dibutyltin dilaurate, was added to the prepolymer 4 prepared as described above.

The prepolymer 4 constituted an oil phase (10 g), and this oil phase was slowly added to the aqueous solution, and all of them were vigorously stirred. Preferably, 10 mole% excess of other glycerin is added (in aqueous solution) and the mixture is heated to 50 ° C. to extend the polymer chain, as outlined below.

At 50 ° C., any free isocyanate is gradually removed through reaction with water, as illustrated schematically below.

After stirring for 1 hour, a total of 2 g of one or more cosmetic active ingredients, in this example 40%: 40%: 10%: 10% by weight carrot oil, sunflower oil extract of aloe, vitamin E acetate and fragrance Add to oil phase (substantially composed of polyurethane polymer).

The emulsion was stirred with a blade mixer for an additional 2 hours to complete the reaction, and the microcapsules thus formed were collected from the aqueous phase, separated and placed in a beaker, washed with deionized water for several hours, and filtered.

Yield was greater than 90%.

C) Lipophilic  Preparation of Suspensions of Polyurethane-Based Microcapsules Containing Cosmetic Active Ingredients

The microcapsules were then introduced into the suspension for subsequent application onto the wiper.

Suspensions were prepared using the following.

i) fluid solvents such as water or a mixture of water and alcohol;

ii) film-forming agents such as gum arabic, hydroxyl cellulose, carboxylated cellulose, acrylic and polyurethane polymers and copolymers, chitosan, polyvinyl alcohol;

iii) anionic or nonionic or amphoteric surfactants. Preferred anionic surfactants are, in particular of 1 to 5 moles of ethylene oxide containing a linear and / or branched C _{8 -18} alkyl chains, sulfate and / or carboxylated or ethoxylated sulfate and / or carboxyl Alcohol having a rate. Preferred nonionic surfactants are alcohols with linear and / or branched C _{8 -22} alkyl chains containing 1 to 40 moles of ethylene oxide. A betaine-preferred amphoteric surfactants are C _{8 -18} alkyl-betaines, C _{8 -18} alkyl amido-beta, and C _{8 -18} alkyl sulfonyl. Particularly preferred surfactants are selected from lauryl ether sulfate, lauryl glucoside, cocamidopropyl betaine.

680 ml of cold deionized water, 20 g of carboxylated cellulose, 100 g of 40% w / w aqueous solution of cocamidopropyl betaine, and 200 g of microcapsules containing carrot oil, sunflower oil extract of aloe, vitamin E acetate and fragrance The mixture was mixed very slowly using a magnetic stirrer to prepare 1 L of a suspension.

E) Cotton wool added with suspension containing microcapsules Nonwoven fabric  Manufacture of sheets

The following step consists of spraying the suspension obtained as described above onto a strip of cotton wool sheet.

The suspension is sprayed at 5-30% by weight, preferably 10-15% by weight, based on the cotton wool sheet.

The strip of cotton wool sheet was then dried in a hot air oven at a temperature of 80 to 120 ° C.

The strip of sheet material obtained was then cut and packaged to obtain a dry wiper having a maximum moisture content of 5% as residual moisture in the materials used.

Claims (13)

Inert plate-like supports;
A plurality of microcapsules containing at least one active ingredient and applied to the plate support; And
At least one surfactant applied to the plate-like support
Dry wiper for applying at least one active ingredient on the skin. The dry wiper of claim 1, wherein the microcapsules are made of polyurethane polymer. The method of claim 1 or 2, wherein the microcapsules are
Difunctional, trifunctional hydroxyl compounds and / or difunctional amine compounds, i) 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, 4,4-diphenylmethane diisocyanate, 2,4-di Homopolymers of phenylmethane diisocyanate, isophorone diisocyanate, methylene bis 4-cyclohexyl diisocyanate, and ii) 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, 4,4-diphenylmethane diisocyanate A dry wiper, made of a polyurethane polymer selected from copolymers of 2,4-diphenylmethane diisocyanate, isophorone diisocyanate, methylene bis 4-cyclohexyl diisocyanate. The method of claim 3, wherein the difunctional, trifunctional hydroxyl compound or difunctional amine compound is
Ethylene glycol, diethylene glycol, propylene glycol, tetraethylene glycol, tripropylene glycol, 1,3-propanediol, 1,4-butanediol, neopentyl glycol, 1,6-hexanediol, 1,4-cyclohexanedimethanol Selected from ethanolamine, methyldiethanolamine, phenyl diethanolamine, diethanolamine, glycerol, trimethylolpropane, 1,2,6-hexanetriol, triethanolamine, diethyltoluenediamine, dimethylthiotoluenediamine, Dry wiper. The dry wiper according to any one of claims 1 to 4, wherein at least one active ingredient is a lipophilic active ingredient. 6. The surfactant according to claim 1, wherein the surfactant
1 to 5 moles of ethylene oxide containing a linear and / or branched C _{8 -18} alkyl chains, sulfate and / or a carboxylate or ethoxylated sulfate and / or an alcohol having carboxylate; Alcohols with linear and / or branched C _{8 -22} alkyl chains containing 1 to 40 moles of ethylene oxide; C _{8 -18} alkyl-betaines, C _{8 -18} alkyl amido-betaines and C _{8 -18} alkyl sulfonate -, dry wiper is selected from betaines. The dry wiper of claim 1, wherein the surfactant is selected from cocamidopropyl betaine, lauryl ether sulfate, lauryl glucoside. The dry wiper according to claim 1, wherein the dry wiper further comprises a film-forming agent applied on the plate-like support. The dry wiper of claim 8, wherein the film-forming agent is selected from gum arabic, hydroxycellulose, carboxylated cellulose, acrylic and polyurethane polymers and copolymers, chitosan, polyvinyl alcohol. 10. Dry wiper according to any one of the preceding claims, wherein the microcapsules further contain at least one fragrance, preferably at least one lipophilic fragrance. The dry wiper according to any one of claims 1 to 10, wherein the inert plate-like support consists of a woven or nonwoven fabric. The dry wiper according to any one of claims 1 to 11, wherein the inert plate-like support is made of cotton, a synthetic material, or a mixture thereof. The dry wiper according to any one of claims 1 to 12, wherein the inert plate-like support is a cotton wool sheet, preferably a water-needled cotton wool sheet.