[go: up one dir, main page]

KR20100093621A - 사포게닌 및 그 유도체의 치료 방법 및 용도 - Google Patents

사포게닌 및 그 유도체의 치료 방법 및 용도 Download PDF

Info

Publication number
KR20100093621A
KR20100093621A KR1020107017081A KR20107017081A KR20100093621A KR 20100093621 A KR20100093621 A KR 20100093621A KR 1020107017081 A KR1020107017081 A KR 1020107017081A KR 20107017081 A KR20107017081 A KR 20107017081A KR 20100093621 A KR20100093621 A KR 20100093621A
Authority
KR
South Korea
Prior art keywords
alkyl
group
alkyl group
pharmaceutically acceptable
unsubstituted
Prior art date
Application number
KR1020107017081A
Other languages
English (en)
Korean (ko)
Inventor
다일 리스
필 구닝
안토니아 오르시
종친 시아
야얼 휴
Original Assignee
파이토팜 피엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ARP020101170A external-priority patent/AR033079A1/es
Application filed by 파이토팜 피엘씨 filed Critical 파이토팜 피엘씨
Publication of KR20100093621A publication Critical patent/KR20100093621A/ko

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/655Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)
KR1020107017081A 2002-03-27 2003-03-27 사포게닌 및 그 유도체의 치료 방법 및 용도 KR20100093621A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
ARP020101170 2002-03-27
ARP020101170A AR033079A1 (es) 2001-03-28 2002-03-27 Derivados de sapogeninas, sintesis y uso, y metodos en base a su uso
US36817802P 2002-03-28 2002-03-28
PCT/GB2002/001578 WO2002079221A2 (en) 2001-03-28 2002-03-28 Sapogenin derivatives, their synthesis and use
WOPCT/GB02/01578 2002-03-28
US60/368,178 2002-03-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020087007136A Division KR20080031062A (ko) 2002-03-27 2003-03-27 사포게닌 및 그 유도체의 치료 방법 및 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020127008441A Division KR20120128596A (ko) 2002-03-27 2003-03-27 사포게닌 및 그 유도체의 치료 방법 및 용도

Publications (1)

Publication Number Publication Date
KR20100093621A true KR20100093621A (ko) 2010-08-25

Family

ID=30001210

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107017081A KR20100093621A (ko) 2002-03-27 2003-03-27 사포게닌 및 그 유도체의 치료 방법 및 용도

Country Status (10)

Country Link
KR (1) KR20100093621A (xx)
CN (1) CN1642558B (xx)
AT (1) ATE424211T1 (xx)
IL (1) IL164161A0 (xx)
NZ (2) NZ547344A (xx)
PE (1) PE20040306A1 (xx)
PL (1) PL213697B1 (xx)
RU (1) RU2332999C2 (xx)
TW (1) TWI329016B (xx)
WO (1) WO2003082893A2 (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861788B2 (en) * 2003-06-03 2005-03-01 Motorola, Inc. Switchable display/mirror method and apparatus
FR2868700B1 (fr) * 2004-04-09 2008-09-26 Michel Coisy Utilisation de la dopamine ou de ses precurseurs biologiques contre l'algoneurodystrphie.
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) * 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
CN101296703B (zh) 2005-10-28 2011-07-27 金善砺 薯蓣科提取物及包含此提取物、用于预防或治疗外周神经疾病的组合物
EA201190115A1 (ru) 2009-01-24 2012-02-28 ФИТОФАРМ ПиЭлСи Лечение расстройств, опосредованных нейротрофическим фактором
JP2013543482A (ja) * 2010-07-20 2013-12-05 ファイトファーム ピーエルシー L−ドーパ、ドーパミン作動薬及び/又はドーパミン賦活剤により誘発される疾患の処置
BR112014005373B1 (pt) 2011-09-08 2022-04-19 Sage Therapeutics, Inc Compostos esteróides neuroativos, composições e usos destes
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
WO2013149580A1 (en) * 2012-04-03 2013-10-10 Chiming Che Timosaponin compounds
IL280068B1 (en) 2013-03-13 2025-02-01 Sage Therapeutics Inc Neuroactivity is modulated at position 24 by hydroxy and alkyl/alkenyl/alkynyl 3beta–hydroxy–cholane and 3beta–hydroxy–chol–5–ene derivatives
CN103232520A (zh) * 2013-05-13 2013-08-07 中国药科大学 一种螺甾类化合物、其制备方法及医药用途
JP6628745B2 (ja) 2014-06-18 2020-01-15 セージ セラピューティクス, インコーポレイテッド オキシステロールおよびその使用方法
RS62220B1 (sr) 2015-07-06 2021-09-30 Sage Therapeutics Inc Oksisteroli i postupci njihovog korišćenja
NZ738582A (en) 2015-07-06 2024-10-25 Sage Therapeutics Inc Oxysterols and methods of use thereof
PH12018500065B1 (en) 2015-07-06 2022-11-04 Sage Therapeutics Inc Oxysterols and methods of use thereof
PT3436022T (pt) 2016-04-01 2022-07-04 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
TWI752976B (zh) 2016-07-07 2022-01-21 美商賽吉醫療公司 氧固醇(oxysterol)及其使用方法
PT3519422T (pt) 2016-09-30 2022-12-05 Sage Therapeutics Inc Oxisteróis substituídos em c7 e métodos como moduladores nmda
DK3529257T3 (da) 2016-10-18 2023-08-07 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf
EP4105223A1 (en) 2016-10-18 2022-12-21 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CN108264535A (zh) * 2016-12-30 2018-07-10 中国科学院上海药物研究所 一种抗抑郁化合物及其制备方法和应用
RU2635485C1 (ru) * 2017-03-21 2017-11-13 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ лечения атрофии зрительного нерва после черепно-мозговой травмы
CN109988218B (zh) * 2017-12-29 2022-11-25 中国科学院上海药物研究所 一种菝葜皂苷元衍生物及其制备方法和应用
EP3572085A1 (en) 2018-05-25 2019-11-27 Neuro-Sys Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and optionnaly a second polyphenolic compound
CN112457362B (zh) * 2019-09-06 2023-09-19 上海青东生物科技有限公司 一种卤代四环三萜衍生物及其制备与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3416112A1 (de) * 1984-04-30 1985-10-31 Roecar Holdings (Netherlands Antilles) N.V., Willemstad, Curacao, Niederländische Antillen Verwendung von sterolinen und spiroketalinen als lipoxygenaseregulatoren
US4680289A (en) * 1985-06-05 1987-07-14 Progenics, Inc. Treatment of obesity and diabetes using sapogenins
JPH05246866A (ja) * 1992-03-06 1993-09-24 Ruibosuteii Japan:Kk 脳代謝促進・脳機能改善剤
DE4303214A1 (de) * 1993-02-04 1994-08-11 Wolfgang Marks Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone
TW479061B (en) * 1993-12-24 2002-03-11 Mitsubishi Chem Corp Sialic acid derivatives
JPH092956A (ja) * 1995-06-22 1997-01-07 Mitsubishi Chem Corp 神経障害の治療、予防薬
JPH092957A (ja) * 1995-06-22 1997-01-07 Mitsubishi Chem Corp 末梢性神経障害の治療、予防薬
US6046185A (en) * 1996-07-11 2000-04-04 Inflazyme Pharmaceuticals Ltd. 6,7-oxygenated steroids and uses related thereto
CN1131237C (zh) * 1997-09-26 2003-12-17 中国人民解放军军事医学科学院放射医学研究所 甾体皂甙防治老年性痴呆的用途及新的甾体皂甙
JP3768100B2 (ja) * 1998-03-26 2006-04-19 ファイトファーム・ピーエルシー アルツハイマー病を治療するためのステロイドサポゲニンとその誘導体
GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
JP2002030096A (ja) * 2000-07-11 2002-01-29 Kyorin Pharmaceut Co Ltd 神経細胞突起再生剤及びその製造方法
AU2003218180B2 (en) * 2002-03-15 2008-03-20 Georgetown University Neuroprotective spirostenol pharmaceutical compositions

Also Published As

Publication number Publication date
ATE424211T1 (de) 2009-03-15
WO2003082893A3 (en) 2004-04-15
RU2004130281A (ru) 2006-01-20
TW200400042A (en) 2004-01-01
CN1642558A (zh) 2005-07-20
NZ547897A (en) 2008-02-29
WO2003082893A8 (en) 2003-12-31
CN1642558B (zh) 2012-05-30
NZ547344A (en) 2007-11-30
IL164161A0 (en) 2005-12-18
PL213697B1 (pl) 2013-04-30
PE20040306A1 (es) 2004-05-29
WO2003082893A2 (en) 2003-10-09
PL372941A1 (en) 2005-08-08
RU2332999C2 (ru) 2008-09-10
TWI329016B (en) 2010-08-21

Similar Documents

Publication Publication Date Title
KR20100093621A (ko) 사포게닌 및 그 유도체의 치료 방법 및 용도
US20110190249A1 (en) Therapeutic methods and uses of sapogenins and their derivatives
RU2325396C2 (ru) Производные 5бета-сапогенина и псевдосапогенина и их применение при лечении деменции
KR100632052B1 (ko) 알츠하이머병을 치료하기 위한 스테로이드계 사포게닌 및 이의 유도체
KR20040007479A (ko) 사포게닌 유도체, 이들의 합성법 및 용도, 및 그 용도에기초한 방법
JPH09165333A (ja) カプサイシン様応答のための可変スペクトルを有する化合物を含有する組成物
JP4970932B2 (ja) コレスト−4−エン−3−オンの誘導体の医薬としての使用、これらを含む医薬組成物、新規誘導体及びそれらの製造方法
CN101133075A (zh) 用于治疗阿尔茨海默氏病和抑制β淀粉样肽生成的化合物
CA3100886C (en) Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and a second polyphenolic compound
US20050130948A1 (en) Therapeutic methods and uses of sapogenins and their derivatives
KR20120128596A (ko) 사포게닌 및 그 유도체의 치료 방법 및 용도
AU2003229877B2 (en) Theraputic methods and uses of sapogenins and their derivatives
KR20080031062A (ko) 사포게닌 및 그 유도체의 치료 방법 및 용도
TWI357816B (en) Therapeutic methods and uses of sapogenins and the
WO2024242517A1 (ko) 한약재 혼합물을 포함하는 비만 예방 또는 약학적 조성물 및 이를 포함하는 주사제
AU781810B2 (en) Steroidal sapogenins and their derivatives for treating Alzheimer&#39;s disease
US20170348340A1 (en) New c-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of genista tenera ethyl acetate extracts containing some of those agents

Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20100729

Application number text: 1020087007136

Filing date: 20080325

PA0201 Request for examination
PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20101020

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20111129

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20101020

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

J201 Request for trial against refusal decision
PJ0201 Trial against decision of rejection

Patent event date: 20120229

Comment text: Request for Trial against Decision on Refusal

Patent event code: PJ02012R01D

Patent event date: 20111129

Comment text: Decision to Refuse Application

Patent event code: PJ02011S01I

Appeal kind category: Appeal against decision to decline refusal

Decision date: 20130603

Appeal identifier: 2012101002170

Request date: 20120229

A107 Divisional application of patent
AMND Amendment
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20120330

Application number text: 1020087007136

Filing date: 20080325

PB0901 Examination by re-examination before a trial

Comment text: Amendment to Specification, etc.

Patent event date: 20120330

Patent event code: PB09011R02I

Comment text: Request for Trial against Decision on Refusal

Patent event date: 20120229

Patent event code: PB09011R01I

Comment text: Amendment to Specification, etc.

Patent event date: 20110420

Patent event code: PB09011R02I

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

Comment text: Final Notice of Reason for Refusal

Patent event date: 20120503

Patent event code: PE09021S02D

B701 Decision to grant
PB0701 Decision of registration after re-examination before a trial

Patent event date: 20130603

Comment text: Decision to Grant Registration

Patent event code: PB07012S01D

Patent event date: 20120406

Comment text: Transfer of Trial File for Re-examination before a Trial

Patent event code: PB07011S01I

PC1904 Unpaid initial registration fee