KR20090104217A - Acne Treatment Composition - Google Patents
Acne Treatment Composition Download PDFInfo
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- KR20090104217A KR20090104217A KR1020080029533A KR20080029533A KR20090104217A KR 20090104217 A KR20090104217 A KR 20090104217A KR 1020080029533 A KR1020080029533 A KR 1020080029533A KR 20080029533 A KR20080029533 A KR 20080029533A KR 20090104217 A KR20090104217 A KR 20090104217A
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- acne
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 73
- 206010000496 acne Diseases 0.000 title claims abstract description 73
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 241000894006 Bacteria Species 0.000 claims abstract description 28
- 244000005700 microbiome Species 0.000 claims abstract description 19
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 239000003755 preservative agent Substances 0.000 claims description 16
- 239000003995 emulsifying agent Substances 0.000 claims description 12
- 230000002335 preservative effect Effects 0.000 claims description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 239000004909 Moisturizer Substances 0.000 claims description 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 8
- 229930195729 fatty acid Natural products 0.000 claims description 8
- 239000000194 fatty acid Substances 0.000 claims description 8
- -1 fatty acid monoglycerides Chemical class 0.000 claims description 8
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- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 241000186361 Actinobacteria <class> Species 0.000 claims description 5
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 5
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- 241000233866 Fungi Species 0.000 description 2
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
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- 150000002632 lipids Chemical class 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
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- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 1
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- 206010033733 Papule Diseases 0.000 description 1
- 241000745768 Pluchea carolinensis Species 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
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- 230000001684 chronic effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
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- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
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- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
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- 235000013379 molasses Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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- 208000029561 pustule Diseases 0.000 description 1
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- 230000001172 regenerating effect Effects 0.000 description 1
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- 235000002020 sage Nutrition 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
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- 210000001732 sebaceous gland Anatomy 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Plant Pathology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Agronomy & Crop Science (AREA)
- Dermatology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 여드름 치료제 조성물에 관한 것으로, 더욱 상세하게는 유효미생물을 배양시킨 배양액 95 내지 97 중량부, 아로마오일 1 내지 2 중량부 및 보습제 2.5 내지 7.5 중량부를 포함하여 이루어지는데, 이러한 여드름 치료제 조성물은 각질에 기생하는 여드름균을 제거하여 여드름의 치료효과를 나타낸다.The present invention relates to an acne treatment composition, and more particularly, comprising 95 to 97 parts by weight of a culture medium in which an effective microorganism is cultured, 1 to 2 parts by weight of aroma oil, and 2.5 to 7.5 parts by weight of a moisturizing agent. It removes acne bacteria that are parasitic on keratin and shows the treatment effect of acne.
Description
본 발명은 여드름 치료에 사용되는 조성물에 관한 것으로, 유효미생물이 함유된 배양액을 첨가하여 여드름균을 제거하고, 여드름균의 증식을 억제하여 여드름의 발생을 예방하고 치료하는 여드름 치료제 조성물에 관한 것이다.The present invention relates to a composition used for the treatment of acne, and to an acne treatment composition for preventing and treating the occurrence of acne by adding a culture medium containing an effective microorganism to remove acne bacteria and inhibiting the growth of acne bacteria.
여드름은 모낭 및 피지선에 발생하는 만성, 난치성, 염증성 피부 질환을 말하는 것으로, 이러한 여드름의 발생원인은 크게 피지 분비의 증가, 모낭의 하이퍼케라토시스(hyperkeratosis)에 의한 협착, 여드름균의 증식, 염증 반응 등으로 여드름 증세의 발전 정도에 따라 설명될 수 있고, 또한 여러가지 메카니즘이 복합적으로 작용할 수도 있다. 즉, 사춘기 이후 증가되는 성호르몬인 에스트로겐(estrogen)은 피지의 분비를 과도하게 증가시켜 모낭의 협착을 유발시킬 수 있다. 또한 피지의 지질 조성은 피부 표피와 달라 산화가 잘되고 또한 여드름균의 에너지원으로 사용되므로 피지의 증가는 여드름을 유발시킬 수 있는 첫번째 요인으로 생각된다. 또한 여드름균은 혐기성 세균으로 모낭이 열린 상황에서는 증식되지 않 는다. 즉, 피지 증가와 모낭의 과각질화가 진행되면 모낭 입구가 막히게 되어 여드름의 초기 병변인 면포(comedones)가 발생되고 여드름균의 과다 증식이 일어나게 된다. 증가된 여드름균은 피지의 지질을 대사하여 자극원이 되는 여러 지방산을 생성하고 또한 여드름균은 항원으로 인식되어 체내의 면역 반응을 자극하여 염증 반응이 일어나게 된다. 이는 구진(papule)과 염증성 여드름 병변의 원인이 되고 악화되면 모낭벽이 파괴되며 조직이 손상되는 낭포, 농포등의 병변으로 발전된다. 여드름의 치료 영역에서는 여러 가지 약재들이 개발되어 사용되고 있지만 적절한 피부 관리를 위한 치료제는 아직까지 연구되지 않은 것이 현실이다.Acne refers to chronic, refractory and inflammatory skin diseases that occur in hair follicles and sebaceous glands. The causes of acne are largely increased sebum secretion, narrowing of hair follicles by hyperkeratosis, proliferation of acne bacteria, and inflammation. The reaction may be explained according to the degree of development of acne symptoms, and various mechanisms may work in combination. In other words, estrogen, a sex hormone that is increased after puberty, may excessively increase sebum secretion and cause narrowing of hair follicles. In addition, the lipid composition of sebum is different from the epidermis of the skin, so it is oxidized well and is used as an energy source of acne bacteria. Acne bacteria are also anaerobic bacteria that do not multiply in the open hair follicles. In other words, when sebum increases and hyperkeratosis of hair follicles progresses, the entrance of the hair follicles is blocked, resulting in acne, an early lesion of acne, and excessive proliferation of acne bacteria. Increased acne bacteria metabolize the lipids of sebum to produce various fatty acids that are stimulants, and acne bacteria are recognized as antigens and stimulate the body's immune response to cause inflammatory reactions. This causes papules and inflammatory acne lesions, and when deteriorated, the follicle wall is destroyed and tissues are damaged, such as cysts and pustules. Although various medicines have been developed and used in the treatment area of acne, the treatment for proper skin care has not been studied yet.
화장품 영역으로는 주로 비누, 약용 비누, 아브레이시브 클린저(abrasive cleanser)등으로 주로 피부 박리를 통해 모낭 협착을 제거하여 여드름을 치유하는 개념이다. 또한 아스트리젠트의 알코올 성분에 의해 피부 박리와 여드름균의 살균 효과도 역시 여드름에 효과가 어느 정도 있다. 또한 레소르시놀(resorcinol), 황(sulfur), 살리실산(salicylic acid), 벤조일퍼옥시드(benzoyl peroxide)등을 함유한 화장품도 있다. 그러나 이러한 원료들은 피부 자극이 있어 사용 농도의 제한이 따르는 등 많은 부작용과 제한이 따르는 실정이다.Cosmetics are mainly soap, medicated soap, and abrasive cleanser, which are the concept of healing acne by removing hair follicle narrowing through skin exfoliation. In addition, the alcohol component of astrigent also exfoliates the skin and disinfects the acne. There are also cosmetics containing resorcinol, sulfur, salicylic acid and benzoyl peroxide. However, these raw materials have a lot of side effects and limitations such as skin irritation due to the restriction of the use concentration.
또한, 여드름균의 제거를 위한 에리드로마이신(erythromycine)등의 항생제나 염증 치료를 위한 항염증(anti-inflamation)원료, 피지 조절을 위한 호르몬 제제들이 사용되지만 이러한 치료제는 인체에 유해한 문제점이 있다.In addition, antibiotics such as erythromycine for removal of acne bacteria, anti-inflamation raw materials for inflammation treatment, and hormone preparations for sebum control are used, but these therapeutic agents are harmful to the human body.
본 발명의 목적은 전술한 문제점을 해결하기 위한 것으로, 인체에 무해한 유효미생물을 배양시킨 배양액을 함유하여 인체에 해를 가하지 않으면서 여드름을 치료하는 여드름 치료제 조성물을 제공하는 것이다.An object of the present invention is to solve the above-mentioned problems, and to provide an acne treatment composition for treating acne without harming the human body by containing a culture medium cultured effective microorganisms harmless to the human body.
또한, 인체에 무해한 천연 방부제를 첨가하여 장기간 보존이 가능한 여드름 치료제 조성물을 제공하는 것이다.In addition, it is to provide an acne therapeutic composition that can be stored for a long time by adding a natural preservative harmless to the human body.
전술한 본 발명의 목적은, 유효미생물을 배양시킨 배양액, 아로마오일 및 보습제를 포함하여 이루어지는 것을 특징으로 하는 여드름 치료제 조성물을 제공함에 의해 달성된다.The object of the present invention described above is achieved by providing an acne therapeutic composition comprising a culture medium, an aroma oil and a moisturizer cultivated effective microorganisms.
본 발명의 바람직한 특징에 따르면, 전술한 여드름 치료제 조성물은 유효미생물을 배양시킨 배양액 95 내지 97 중량부, 아로마오일 1 내지 2 중량부 및 보습제 2.5 내지 7.5 중량부를 포함하여 이루어진다.According to a preferred feature of the present invention, the aforementioned acne treatment composition comprises 95 to 97 parts by weight of the culture cultured the effective microorganism, 1 to 2 parts by weight of aroma oil and 2.5 to 7.5 parts by weight of the moisturizer.
본 발명의 바람직한 특징에 따르면, 전술한 유효미생물은 효모, 유산균, 방선균 및 광합성세균을 포함하여 이루어진다.According to a preferred feature of the present invention, the above-mentioned effective microorganism comprises yeast, lactic acid bacteria, actinomycetes and photosynthetic bacteria.
본 발명의 더 바람직한 특징에 따르면, 전술한 여드름 치료제 조성물에는 유화제가 더 포함되는 것을 특징으로 한다.According to a more preferred feature of the invention, the aforementioned acne treatment composition is characterized in that it further comprises an emulsifier.
본 발명의 더욱 바람직한 특징에 따르면, 전술한 유화제는 지방산모노글리세 리드, 지방산에스테르, 레시틴 및 알긴산으로 이루어진 그룹으로부터 선택된 하나 이상으로 이루어진다.According to a further preferred feature of the invention, the emulsifier described above consists of at least one selected from the group consisting of fatty acid monoglycerides, fatty acid esters, lecithin and alginic acid.
본 발명의 더욱 바람직한 특징에 따르면, 전술한 여드름 치료제 조성물에는 방부제가 더 포함되는 것을 특징으로 한다.According to a more preferred feature of the present invention, the aforementioned acne treatment composition is characterized in that it further comprises a preservative.
본 발명의 더욱 바람직한 특징에 따르면, 전술한 방부제는 방부제는 녹차, 카모마일, 자몽, 나한백 및 버드나무 추출물로 이루어진 그룹으로부터 선택된 하나 이상을 포함하여 이루어지는 것을 특징으로 한다.According to a more preferred feature of the present invention, the above-mentioned preservatives are characterized in that the preservative comprises at least one selected from the group consisting of green tea, chamomile, grapefruit, nahanbaek and willow extract.
본 발명에 의한 여드름 치료제 조성물은 유효미생물을 배양시킨 배양액이 첨가되어 여드름이 발생한 피부에 도포하면 여드름균을 제거하여 여드름 치료에 탁월한 효과를 나타낸다.Acne treatment composition according to the present invention is added to the culture medium in which the effective microorganisms are added and applied to the skin where acne has occurred to remove the acne bacteria shows an excellent effect in the treatment of acne.
또한, 방부제는 녹차, 카모마일, 자몽, 나한백 및 버드나무 추출물로 이루어진 그룹으로부터 선택된 하나 이상으로 이루어진 천연방부제가 함유되어 보존기간에 탁월한 효과를 나타낸다.In addition, the preservative contains a natural preservative composed of one or more selected from the group consisting of green tea, chamomile, grapefruit, nahanbaek and willow extract shows an excellent effect on the shelf life.
이하에는, 본 발명의 바람직한 실시예와 각 성분의 물성을 상세하게 설명하되, 이는 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 발명을 용이하게 실시할 수 있을 정도로 상세하게 설명하기 위한 것이지, 이로 인해 본 발명의 기술적인 사상 및 범주가 한정되는 것을 의미하지는 않는다.In the following, preferred embodiments of the present invention and the physical properties of each component will be described in detail, which is intended to explain in detail enough to be able to easily carry out the invention by one of ordinary skill in the art, This does not mean that the technical spirit and scope of the present invention is limited.
본 발명에 따른 여드름 치료제 조성물은 여드름균을 제거하는 유효미생물을 배양시킨 배양액, 여러가지 향이 나는 아로마오일 및 피부 보습효과를 나타내는 보습제를 포함하여 이루어진다.The acne treatment composition according to the present invention comprises a culture medium in which an effective microorganism is removed to remove acne bacteria, various flavored aroma oils, and a moisturizer exhibiting a skin moisturizing effect.
본 발명에 따른 여드름 치료제 조성물의 조성을 상세히 살펴보면, 유효미생물을 배양시킨 배양액 95 내지 97 중량부, 아로마오일 1 내지 2 중량부 및 보습제 2.5 내지 7.5 중량부를 포함하여 이루어지며, 이 외에 유화제 및 분산제를 더 포함하여 이루어지는 것이 바람직하다.Looking at the composition of the acne treatment composition according to the present invention in detail, it comprises 95 to 97 parts by weight of the culture cultured the effective microorganism, 1 to 2 parts by weight of aroma oil and 2.5 to 7.5 parts by weight of moisturizer, in addition to the emulsifier and dispersant It is preferable to comprise.
전술한 유효미생물을 배양시킨 배양액은 효모, 유산균, 방선균 및 광합성세균으로 이루어진 균류를 정제수와 혼합하여 이루어지는 유효미생물 원액을 쌀뜨물에 혼합하고 밀폐시켜서 배양하는데, 더욱 자세하게는 쌀뜨물 500밀리리터 준비한 후에 당밀 또는 설탕을 녹여 약 30 내지 40 밀리리터를 넣고 효모, 유산균, 방선균 및 광합성세균으로 이루어진 균류를 정제수와 혼합하여 이루어지는 유효미생물 원액을 30 내지 40 밀리리터 넣은 후에 밀폐용기에서 4 내지 7일 동안 20 내지 25℃의 온도를 유지하면서 배양시킨다.The culture medium in which the above-mentioned effective microorganisms are cultured is cultured by mixing an effective microbial stock solution consisting of yeast, lactic acid bacteria, actinomycetes and photosynthetic bacteria with purified water and mixing it with rice water and sealing it. Alternatively, add about 30 to 40 milliliters of sugar, add 30 to 40 milliliters of the effective microbial stock solution obtained by mixing fungi consisting of yeast, lactic acid bacteria, actinomycetes and photosynthetic bacteria with purified water, and then put them in a sealed container for 20 to 25 ℃ for 4 to 7 days. Incubate while maintaining the temperature.
4 내지 7일 이후에 달콤한 향이 나고 가스가 배출되지 않으면 완성된 것인데 가스가 배출될 경우에는 밀폐용기를 천천히 개방해서 가스를 방출하고 다시 밀폐한 후에 배양을 진행시킨다.After 4 to 7 days, the sweet scent and no gas is discharged, but the gas is discharged. If the gas is discharged, slowly open the airtight container to release the gas, and then close the air before culturing.
본 발명에 따른 여드름 치료용 조성물에는 유효미생물을 배양시킨 배양액이 95 내지 97 중량부로 비교적 많은 양의 배양액이 첨가되는데, 이는 배양액이 피지에 분포하는 여드름균에 즉각적이며 지속적으로 작용하기 위한 함량으로 95 중량부 미만일 경우에는 여드름 치료효과가 오래 지속되지 못하기 때문이다.In the acne treatment composition according to the present invention, a culture medium in which effective microorganisms are cultured is added to a relatively large amount of 95 to 97 parts by weight, which is a content for immediate and continuous action of the culture medium on acne bacteria distributed in sebum. If the weight is less than the acne treatment effect does not last long.
아로마오일은 추출식물에 따라 여러 가지 좋은 향을 내기 때문에 치료제의 향을 좋게 할 뿐만 아니라 박테리아 막아내는 효능이 있어 피지에서 여드름균이 제거되어 여드름이 치료된 후에 호르몬의 이상으로 피지량이 증가함에 따른 여드름균의 재차 감염을 예방하는 역할을 한다.Aroma oil has various good scents depending on the extracting plant, which not only improves the scent of the therapeutic agent but also has the effect of preventing bacteria. Acne bacteria are removed from sebum, and acne is increased after hormone treatment after acne is removed. It plays a role in preventing the infection of bacteria again.
전술한 아로마오일의 종류는 티트리오일, 꽃에서 추출하는 장미, 자스민, 캐모마일 아로마 오일과 잎에서 추출하는 세이지, 레몬밤, 타임 아로마 오일 및 뿌리에서 추출하는 앤젤리카, 창포 아로마오일 등이 있으며, 이 밖에도 씨, 나무껍질 및 과실껍질 등에서 추출하는 아로마 오일이 이용된다.The above-mentioned aromatic oils include tea tree oil, rose extracted from flowers, jasmine, chamomile aromatic oil and sage extracted from leaves, lemon balm, thyme aromatic oil and angelica extracted from root, iris aroma oil, etc. In addition, aromatic oils extracted from seeds, bark and fruit bark are used.
보습제는 호르몬 이상으로 피지가 과다 분비되면 세수를 자주 하게 되는데 이에 따른 피부표면이 약해지는 것을 보완하기 위한 것으로 올리브유, 동백기름 및 달맞이유 등의 천연 보습제가 사용된다.Moisturizers often wash the face of excess sebum due to hormones, which are used to compensate for the weakening of the skin. Natural moisturizers such as olive oil, camellia oil, and evening primrose oil are used.
전술한 천연보습제는 불포화지방산이 다량 함유되어 피부의 재생이나 보습에 매우 효과적이다.The above-mentioned natural moisturizer contains a large amount of unsaturated fatty acid, which is very effective for regenerating or moisturizing the skin.
유화제는 여드름 치료제 조성물에 첨가되어 유효미생물을 배양시킨 배양액과 아로마 오일의 혼합이 잘 이루어지게 하는 역할뿐만 아니라 치료하고자 하는 피부 에 피지가 과다하게 분비되었을 경우에 피지층과 전술한 여드름 치료제 조성물 사이에서 계면활성제로서의 역할을 하기 때문에 피지층과 여드름 치료제 조성물의 반응이 빠르게 진행될 수 있게 하는 역할을 하며, 그 성분은 지방산모노글리세리드, 지방산에스테르, 레시틴 및 알긴산으로 이루어진 그룹으로부터 선택된 하나 이상으로 이루어진다.The emulsifier is added to the acne treatment composition to facilitate the mixing of the cultured culture with the effective microorganisms and the aroma oil, as well as between the sebaceous layer and the acne treatment composition described above when excessive sebum is secreted into the skin to be treated. Since it serves as a surfactant, the reaction between the sebaceous layer and the acne treatment composition is accelerated, and the component is composed of one or more selected from the group consisting of fatty acid monoglycerides, fatty acid esters, lecithin and alginic acid.
방부제는 천연성분으로 구성되는 여드름 치료제 조성물을 장기간 보존하기 위한 것으로, 천연방부제를 사용하는 것이 바람직하다. 방부제로는 녹차, 카모마일, 자몽, 나한백 및 버드나무 추출물로 이루어진 그룹으로부터 선택된 하나 이상을 포함하여 이루어지며, 보존기간이 약 1년 정도로 늘어나게 된다.Preservatives are for long-term preservation of acne therapeutic composition consisting of natural ingredients, it is preferred to use natural preservatives. Preservatives include one or more selected from the group consisting of green tea, chamomile, grapefruit, na hanbaek and willow extract, the shelf life is increased to about 1 year.
전술한 방부제를 추출하는 방법은 크게 세 가지가 주로 사용되는데, 유기 용매를 사용하여 추출하는 방법, 고온추출방법 및 냉침추출방법이 있다.Three methods are mainly used for extracting the above-mentioned preservative, and there are a method of extracting using an organic solvent, a high temperature extraction method, and a cold leaching extraction method.
먼저 유기용매를 사용하여 추출하는 방법은 메탄올, 에탄올, 이소프로탄올, 부탄올 등의 알콜, 에틸렌, 아세톤, 에테르, 헥산, 클로로포름, 에틸아세테이트, DMF (N,N-디메틸포름아미드), DMSO (디메틸설폭사이드), 이들의 혼합물 등을 이용하여 실온에서 또는 가온하여 유기 용매로 추출하는 방법이다.First, the extraction method using an organic solvent is alcohol such as methanol, ethanol, isoprotanol, butanol, ethylene, acetone, ether, hexane, chloroform, ethyl acetate, DMF (N, N-dimethylformamide), DMSO (dimethyl Sulfoxide), a mixture thereof, and the like, at room temperature or by heating to extract with an organic solvent.
또한, 고온 추출하는 방법은, 원재를 물 및 유기 용매에 가하여 70 내지 90℃에서 1 시간 내지 4 시간 이상 가열하여 추출한다.Moreover, in the method of high temperature extraction, a raw material is added to water and an organic solvent, and it extracts by heating at 70-90 degreeC for 1 hour-4 hours or more.
또한, 냉침추출방법은 부유하는 고체 입자를 제거하기 나일론과 같은 함성섬유로 이루어진 필터를 통해 여과하고 그대로 사용하거나 이를 동결건조, 진공건조, 열풍건조, 분무건조 등을 이용해 건조시켜 사용한다.In addition, the cold extraction method is used to filter through a filter made of a constituent fiber such as nylon to remove the suspended solid particles or use it as it is or use it by drying by freeze drying, vacuum drying, hot air drying, spray drying.
이하에서는 본 발명의 따른 여드름 치료제 조성물의 제조방법 및 임상실험결과를 실시예를 들어 설명한다.Hereinafter will be described with reference to the production method and clinical experiment results of the acne treatment composition according to the present invention.
비교예 1>Comparative Example 1
쌀뜨물 500밀리리터 준비한 후에 당밀 또는 설탕을 녹여 약 35 밀리리터를 넣고 효모, 유산균, 방선균 및 광합성세균으로 이루어진 균류를 정제수와 혼합하여 이루어지는 유효미생물 원액을 35 밀리리터 넣은 후에 밀폐용기에서 6일 동안 22 ℃의 온도를 유지하면서 유효미생물을 배양시킨 배양액 93 중량부 아로마오일로는 티트리오일 2 중량부 및 보습제 5 중량부 유화제로 지방산에스테르 2 중량부 및 방부제로 녹차추출액 0.5 중량부를 혼합하여 제조된 여드름 치료제 조성물을 제조하였다.After preparing 500 milliliters of rice water, add 35 milliliters of molasses or sugar, and add 35 milliliters of the effective microbial stock solution obtained by mixing fungi consisting of yeast, lactic acid bacteria, actinomycetes and photosynthetic bacteria with purified water. 93 parts by weight of the culture medium incubated effective microorganisms while maintaining the temperature as an acne therapeutic composition prepared by mixing 2 parts by weight of tea tree oil and 5 parts by weight of emulsifier and 2 parts by weight of fatty acid ester with emulsifier and 0.5 parts by weight of green tea extract with preservative Was prepared.
실시예 1>Example 1
비교예 1의 방법으로 제조된 유효미생물을 배양시킨 배양액 95 중량부 아로마오일 2 중량부 및 보습제 5 중량부 유화제 2 중량부 및 방부제 0.5 중량부를 혼합하여 제조된 여드름 치료제 조성물을 제조하였다.An acne treatment composition prepared by mixing 95 parts by weight of 2 parts by weight of aroma oil, 5 parts by weight of an emulsifier, and 0.5 parts by weight of a preservative was mixed.
비교예 2>Comparative Example 2
비교예 1의 방법으로 제조된 유효미생물을 배양시킨 배양액 90 중량부 아로마오일 2 중량부 및 보습제 5 중량부 유화제 2 중량부 및 방부제 0.5 중량부를 혼합하여 제조된 여드름 치료제 조성물을 제조하였다.An acne treatment composition prepared by mixing 90 parts by weight of 2 parts by weight of aroma oil, 5 parts by weight of an emulsifier, and 0.5 parts by weight of a preservative was mixed.
실시예 2>Example 2
비교예 1의 방법으로 제조된 유효미생물을 배양시킨 배양액 97 중량부 아로마오일 2 중량부 및 보습제 5 중량부 유화제 2 중량부 및 방부제 0.5 중량부를 혼합하여 제조된 여드름 치료제 조성물을 제조하였다.An acne treatment composition prepared by mixing 97 parts by weight of 2 parts by weight of aroma oil, 5 parts by weight of an emulsifier, and 0.5 parts by weight of an emulsifier and 0.5 parts by weight of a preservative was prepared.
비교예 1, 2에 의해 제조된 여드름 치료제 조성물과 실시예 1, 2에 의해 제조된 여드름 여드름 치료제 조성물에 대한 효과를 각각 확인하기 위하여 안면에 여드름의 갯수가 20개 이상인 15 내지 25 살의 임상실험 대상자 총 80명을 비교예와 실시예 별로 각 20명씩 분류하여 임상실험하였다. 단, 피부타입은 지성 25명, 건성 25명 및 정상 30명이 각 비교예 및 실시예에 고르게 분포하도록 분류했다.15 to 25 year old clinical subjects having more than 20 acne in the face to confirm the effects on the acne treatment composition prepared by Comparative Examples 1 and 2 and the acne treatment composition prepared by Examples 1 and 2, respectively. A total of 80 patients were classified into 20 groups for each of Comparative Examples and Examples. However, skin types were classified such that 25 oily, 25 dry and 30 normal were distributed evenly in each of the comparative examples and examples.
임상실험 대상자들은 제조된 여드름 치료제 조성물을 하루에 3회씩 3일간 9회를 바르도록 하여 실험 결과를 아래와 같이 얻었다.Clinical trial subjects were applied to the prepared acne treatment composition three times a day 9 times for 3 days to obtain the experimental results as follows.
전술한 임상실험 후에 여드름 치료효과에 대한 설문을 통해 아래와 같은 표를 얻었다.The following table was obtained through a questionnaire on the effect of acne treatment after the aforementioned clinical trial.
표 1>Table 1>
표 2>Table 2>
상기에 나타낸 비교예 1,2 및 실시예 1,2를 통해 유효미생물을 배양시킨 배양액은 피부에 발생한 피지에 분포하는 여드름균에 작용하여 여드름균을 제거함으 로 인해 여드름을 치료하는 효과가 있는 것을 확인할 수 있었다.The culture medium in which the effective microorganisms were cultured through Comparative Examples 1 and 2 and Examples 1 and 2 shown above were effective in treating acne by removing acne bacteria by acting on acne bacteria distributed in sebum generated on the skin. I could confirm it.
또한, 전술한 표 1,2에 나타낸 설문결과와 같이 유효미생물을 배양시킨 배양액의 함량이 95 중량부 미만일 때는 실험자들의 여드름 치료만족도가 떨어지는 것을 확인할 수 있었다.In addition, as shown in the above-mentioned questionnaire results shown in Tables 1 and 2, when the content of the culture medium in which the effective microorganism was cultured was less than 95 parts by weight, it was confirmed that the satisfaction of the acne treatment satisfaction of the experimenters was lowered.
또한, 유효미생물을 배양시킨 배양액의 함량이 97 중량부 이상이 될 경우에는 배양액 자체에서 발생하는 역한 냄새는 휘발성으로 인해 증발된다.In addition, when the content of the culture medium in which the effective microorganism is cultured is more than 97 parts by weight, the reverse odor generated in the culture medium itself is evaporated due to volatility.
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| US9675650B2 (en) | 2012-10-31 | 2017-06-13 | Amorepacific Corporation | Composition for removing keratinous skin material comprising green tea Lactobacillus |
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