KR20090027752A - 구강 질환 치료를 위한 약초 조성물 - Google Patents
구강 질환 치료를 위한 약초 조성물 Download PDFInfo
- Publication number
- KR20090027752A KR20090027752A KR1020097002083A KR20097002083A KR20090027752A KR 20090027752 A KR20090027752 A KR 20090027752A KR 1020097002083 A KR1020097002083 A KR 1020097002083A KR 20097002083 A KR20097002083 A KR 20097002083A KR 20090027752 A KR20090027752 A KR 20090027752A
- Authority
- KR
- South Korea
- Prior art keywords
- sodium
- composition
- bioadhesive
- purified water
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 235000012756 tartrazine Nutrition 0.000 description 1
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- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
성분 | 중량% |
테트라히드로커큐민 | 6.00 |
중탄산나트륨 | 0.5 |
염화나트륨 | 0.7 |
폴리에틸렌 글리콜 400 | 30.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
삭카린 나트륨 | 0.40 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 100000) | 1 |
정제수 | 20 |
소르비톨 용액 70 % | QS (전체 100중량 %를 만들기 위한 충분량; 이하 동일) |
성분 | 중량% |
테트라히드로커큐민 | 6.00 |
염화나트륨 | 1.20 |
스피아민트 오일 | 1.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 100000) | 3.00 |
삭카린 나트륨 | 0.80 |
정제수 | QS |
성분 | 중량% |
강황(C. longa)의 근경 분말 | 6.00 |
중탄산나트륨 | 1.00 |
염화나트륨 | 1.50 |
수크로오스 | 20.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 50000) | 1.50 |
삭카린 나트륨 | 0.20 |
티타늄디옥사이드 | 2.00 |
시트르산 | 0.50 |
스피아민트 오일 | 0.90 |
정제수 | QS |
성분 | 중량% |
강황(C. longa) 추출물 (95 %) | 0.014 |
중탄산나트륨 | 1.50 |
염화나트륨 | 1.75 |
수크로오스 | 25.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 50000) | 1.50 |
삭카린 나트륨 | 0.20 |
티타늄디옥사이드 | 1.00 |
시트르산 | 0.80 |
스피아민트 오일 | 0.90 |
정제수 | QS |
성분 | 중량% |
강황(C. longa)의 근경 분말 | 0.4 |
중탄산나트륨 | 1.20 |
염화나트륨 | 1.20 |
수크로오스 | 25.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 50000) | 1.50 |
삭카린 나트륨 | 0.20 |
티타늄디옥사이드 | 1.00 |
시트르산 | 0.80 |
브릴리언트 블루 | 0.0007 |
착향료 라임소다 | 0.90 |
정제수 | QS |
성분 | 중량% |
강황(C. longa)의 근경 분말 | 0.4 |
중탄산나트륨 | 1.0 |
염화나트륨 | 1.75 |
수크로오스 | 25.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 50000) | 1.50 |
삭카린 나트륨 | 0.20 |
티타늄디옥사이드 | 1.00 |
시트르산 | 0.80 |
브릴리언트 블루 | 0.0007 |
착향료 라임소다 | 0.90 |
정제수 | QS |
성분 | 중량% |
강황(C. longa) 추출물 (95 %) | 0.016 |
중탄산나트륨 | 0.50 |
염화나트륨 | 1.00 |
수크로오스 | 25.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 50000) | 1.50 |
삭카린 나트륨 | 0.20 |
티타늄디옥사이드 | 1.00 |
시트르산 | 0.80 |
브릴리언트 블루 | 0.0006 |
스피아민트 오일 | 0.90 |
정제수 | QS |
성분 | 중량% |
강황(C. longa) 추출물 (95 %) | 0.016 |
중탄산나트륨 | 1.20 |
염화나트륨 | 1.20 |
수크로오스 | 25.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 50000) | 1.50 |
삭카린 나트륨 | 0.20 |
티타늄디옥사이드 | 1.00 |
시트르산 | 0.80 |
시트르산 나트륨 | 0.50 |
메타중아황산나트륨 | 0.08 |
브릴리언트 블루 | 0.0003 |
스피아민트 오일 | 0.90 |
정제수 | QS |
성분 | 중량% |
강황(C. longa) 추출물 (95 %) | 1.3 |
중탄산나트륨 | 0.50 |
염화나트륨 | 1.00 |
수크로오스 | 25.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 50000) | 1.50 |
삭카린 나트륨 | 0.20 |
티타늄디옥사이드 | 2.40 |
시트르산 | 0.80-1.0 |
시트르산 나트륨 | 0.80-1.0 |
메타중아황산나트륨 | 0.10 |
브릴리언트 블루 | 0.00176 |
착향료 라임소다 | 1.20 |
정제수 | QS |
성분 | 중량% |
강황(C. longa) 추출물 (95 %) | 1.3 |
염화나트륨 | 1.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
카보폴 934P | 1.0 |
폴리에틸렌 글리콜 400 (PEG 400) | 10.00 |
페뮬린 TR-2(페뮬린 TR-2) | 0.30 |
스팬 80(Span 80) | 0.20 |
삭카린 나트륨 | 0.30 |
시트르산 | 1.00 |
메타중아황산나트륨 | 0.10 |
브릴리언트 블루 | 0.0033 |
착향료 라임소다 | 1.50 |
정제수 | QS |
성분 | 중량% |
강황(C. longa) 추출물 (95%) | 1.3 |
중탄산나트륨 | 0.50 |
염화나트륨 | 0.50 |
수크로오스 | 20.00 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
소듐 카르복시메틸 셀룰로오즈 (Cekol 50000) | 1.00 |
프로필렌 글리콜 | 2.50 |
히드록시프로필 메틸셀룰로오즈 (100 LV) | 10.00 |
삭카린 나트륨 | 0.20 |
시트르산 | 1.60 |
메타중아황산나트륨 | 0.10 |
정제수 | QS |
성분 | 중량% |
강황(C. longa) 추출물 (95 %) | 1.3 |
염화나트륨 | 1.5 |
중탄산나트륨 | 1.2 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
히드록시프로필 셀룰로오즈 (Klucel HXF) | 3.0 |
폴리에틸렌 글리콜 400 | 70.00 |
글리세린 | 4.00 |
삭카린 나트륨 | 0.20 |
시트르산 | 1.60 |
메타중아황산나트륨 | 0.10 |
정제수 | QS |
성분 | 중량% |
강황(C. longa) 추출물 (95 %) | 1.3 |
중탄산나트륨 | 1.50 |
염화나트륨 | 1.50 |
메틸 파라벤 | 0.18 |
프로필 파라벤 | 0.02 |
히드록시프로필 셀룰로오즈 (Klucel HXF) | 2.00 |
N-메틸 피롤리돈 (Pharmasolve) | 27.00 |
폴리옥시에칠렌경화피마자유 40 (Polyoxyl 40 hydrogenated castor oil) (Cremophor RH40) | 2.00 |
삭카린 나트륨 | 0.20 |
시트르산 | 2.40 |
정제수 | QS |
Sr. No. | 실시예 No. | 생접착 강도 (그램) |
1 | 2 | 1.85 |
2 | 3 | 1.55 |
3 | 5 | 2.0 |
4 | 8 | 2.35 |
5 | 9 | 2.40 |
6 | 11 | 1.65 |
7 | 13 | 1.70 |
Claims (8)
- (a) 약 0.01% 내지 약 10%의 커큐미노이드 성분과,(b) 하나 이상의 폴리머와,(c) 염화나트륨, 중탄산나트륨, 또는 이들의 혼합물과,(d) 적어도 하나의 약제학적으로 허용가능한 첨가제를 포함하는 구강 처치용 생접착성 조성물.
- 제1항에 있어서,상기 커큐미노이드 성분은 커큐민(curcumin), 테트라히드로커큐민(tetrahydrocurcumin), 비스히드로커큐민(bishydrocurcumin), 강황(Curcuma longa) 생약(crude drug) 및 강황(Curcuma longa) 용매 추출물로 구성된 군으로부터 선택되는 것을 특징으로 하는 구강 처치용 생접착성 조성물.
- 제1항에 있어서,상기 폴리머는 하드록시프로필 셀룰로오즈, 히드록시프로필 메틸셀룰로오즈, 소듐 카르복시메틸 셀룰로오즈, 히드록시에틸 셀룰로오즈 및 카보머(carbomers)로 구성된 군으로부터 선택되는 것을 특징으로 하는 구강 처치용 생접착성 조성물.
- 제1항에 있어서,상기 조성물 중량에 대해 2중량%까지 염화나트륨을 포함하는 구강 처치용 생접착성 조성물.
- 제1항에 있어서,상기 조성물 중량에 대해 2중량%까지 중탄산나트륨을 포함하는 구강 처치용 생접착성 조성물.
- 제1항 내지 제5항 중 어느 한 항에 있어서,상기 조성물은 약 1.5 내지 3.5 그램(grams)의 생접착 강도를 나타내는 것을 특징으로 하는 구강 처치용 생접착성 조성물.
- 치은염 및 다른 치주질환을 치료 및 예방하는 방법에 있어서,치료가 필요한 환자에게 청구항 제1항 내지 제6항 중 어느 한 항에 정의된 생접착성 조성물의 유효량을 구강에 적용하는 것을 포함하는 치은염 및 다른 치주질환을 치료 및 예방하는 방법.
- 청구항 제1항 내지 제5항 중 어느 한 항에 정의된 생접착성 조성물의 용도로서, 치은염 및 다른 치주질환의 치료용 의약 제조를 위한 생접착성 조성물의 용도.
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IN1049MU2006 | 2006-06-30 | ||
IN1049/MUM/2006 | 2006-06-30 |
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US (1) | US8182843B2 (ko) |
EP (1) | EP2046360A4 (ko) |
JP (1) | JP2009542620A (ko) |
KR (1) | KR20090027752A (ko) |
CN (1) | CN101505769A (ko) |
BR (1) | BRPI0713574A2 (ko) |
CA (1) | CA2656308A1 (ko) |
IL (1) | IL195986A0 (ko) |
MX (1) | MX2008016486A (ko) |
NZ (1) | NZ573763A (ko) |
RU (1) | RU2450819C2 (ko) |
WO (1) | WO2008001325A2 (ko) |
ZA (1) | ZA200900712B (ko) |
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US20100183524A1 (en) * | 2008-11-26 | 2010-07-22 | Perio Sciences, Llc | Antioxidant compositions for soft oral tissue and methods of formulation and use thereof |
CN102762200B (zh) * | 2009-12-18 | 2015-01-14 | 高露洁-棕榄公司 | 作为抗微生物剂的增强剂的查尔酮 |
AT509777B1 (de) * | 2010-04-30 | 2012-03-15 | Orphanidis Pharma Res Gmbh | Adhesive retardformulierungen zur lokalen verabreichung von curcumin |
CA2849910A1 (en) | 2011-09-30 | 2013-04-04 | Perio Sciences, Llc | Antioxidant compositions for treatment of inflammation or oxidative damage |
WO2014206960A1 (en) | 2013-06-26 | 2014-12-31 | Novozymes A/S | Process for manufacturing a feed composition |
IN2013MU01590A (ko) * | 2013-11-02 | 2015-08-07 | Jatin Vasant Thakkar | |
FR3022140B1 (fr) * | 2014-06-13 | 2016-06-03 | Laurent Haddad | Composition d'un dispositif medical ou produit cosmetique a base d'extrait de pepin de pamplemousse, d'extrait de feuille d'alchemille, d'extrait de stevia et de curcumine |
CN105688067A (zh) * | 2016-03-18 | 2016-06-22 | 董燕妮 | 治疗阴虚血亏型盗汗的中药组合物 |
WO2018175522A1 (en) * | 2017-03-21 | 2018-09-27 | Gross Andrew J | Compositions for treating periodontal diseases |
DE102017222955A1 (de) * | 2017-12-15 | 2019-06-19 | Henkel Ag & Co. Kgaa | Verdicktes Ein-Komponenten-Haartönungsmittel |
WO2019203813A1 (en) * | 2018-04-18 | 2019-10-24 | Muhammed Majeed | Compositions containing tetrahydrocurcuminoids for improvement of oral health and hygiene |
US20190321308A1 (en) * | 2018-04-18 | 2019-10-24 | Muhammed Majeed | Compositions containing tetrahydrocurcuminoids for improvement of oral health and hygiene |
US20220395441A1 (en) * | 2019-12-26 | 2022-12-15 | Colgate-Palmolive Company | Methods for Improving Barrier Integrity of Gingival Tissue |
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2007
- 2007-06-29 CN CNA2007800247498A patent/CN101505769A/zh active Pending
- 2007-06-29 CA CA002656308A patent/CA2656308A1/en not_active Abandoned
- 2007-06-29 MX MX2008016486A patent/MX2008016486A/es active IP Right Grant
- 2007-06-29 JP JP2009517564A patent/JP2009542620A/ja active Pending
- 2007-06-29 WO PCT/IB2007/052521 patent/WO2008001325A2/en active Application Filing
- 2007-06-29 RU RU2009102390/15A patent/RU2450819C2/ru not_active IP Right Cessation
- 2007-06-29 BR BRPI0713574-2A patent/BRPI0713574A2/pt not_active IP Right Cessation
- 2007-06-29 EP EP07789827A patent/EP2046360A4/en not_active Withdrawn
- 2007-06-29 KR KR1020097002083A patent/KR20090027752A/ko not_active Abandoned
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WO2008001325A3 (en) | 2009-04-30 |
CA2656308A1 (en) | 2008-01-03 |
MX2008016486A (es) | 2009-01-22 |
US8182843B2 (en) | 2012-05-22 |
IL195986A0 (en) | 2009-09-01 |
US20090297644A1 (en) | 2009-12-03 |
ZA200900712B (en) | 2010-03-31 |
AU2007264709A1 (en) | 2008-01-03 |
CN101505769A (zh) | 2009-08-12 |
EP2046360A4 (en) | 2011-01-26 |
BRPI0713574A2 (pt) | 2012-10-23 |
RU2450819C2 (ru) | 2012-05-20 |
WO2008001325A2 (en) | 2008-01-03 |
EP2046360A2 (en) | 2009-04-15 |
RU2009102390A (ru) | 2010-08-10 |
JP2009542620A (ja) | 2009-12-03 |
NZ573763A (en) | 2012-06-29 |
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