KR102728366B1 - Natural shampoo bar comprising panax ginseng extracted surfactant and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a natural shampoo bar comprising a ginseng-extracted surfactant and a method for producing the same. Specifically, the present invention provides a natural shampoo bar comprising a surfactant extracted from ginseng, wherein the surfactant contains saponin and exhibits an activity of inhibiting inflammatory cell-activating substances, thereby improving and preventing dandruff and itching without side effects.

Description

{NATURAL SHAMPOO BAR COMPRISING PANAX GINSENG EXTRACTED SURFACTANT AND MANUFACTURING METHOD THEREOF}

The present invention relates to a natural shampoo bar comprising a ginseng-extracted surfactant and a method for producing the same. Specifically, the present invention provides a natural shampoo bar comprising a surfactant extracted from ginseng, wherein the surfactant contains saponin and exhibits an activity of inhibiting inflammatory cell-activating substances, thereby improving and preventing dandruff and itching without side effects.

The occurrence of hair loss is divided into environmental factors such as fatigue, stress, disease, and environmental changes such as drugs, and genetic factors. In the case of male hair loss, genetic factors and androgen hormones are reported to be important factors, and in female hair loss, some are presumed to occur in the same path as male hair loss, but there are clinical differences. Women have less testosterone hormone secretion and therefore less DHT production, so their hair loss rate is 50% lower than that of men, and androgen alopecia can occur in the 20s, and when female hormones decrease, hair follicles weaken and aromatase causes hair loss or widening of the parting. Since the scalp becomes thinner and pores do not open smoothly, sebum and sweat are not discharged out, but enter the hair follicles, causing damage to the hair root. Therefore, it is necessary to always keep the scalp clean by removing dead skin cells and waste products, open pores and sweat glands (sweat pores) to supply nutrients, and induce hair follicle strengthening and dermal cell proliferation to activate hair follicle cells, thereby inducing a hair loss suppression effect.

Hair is easily contaminated with oil, waste, and dust, so use detergents such as shampoo and soap to wash away sweat, sebum, and dust attached to the hair. Shampoo washes away sweat, sebum, and dust attached to the hair, and at the same time, keeps the hair clean and gives it shine. There are wet shampoos that use water and dry shampoos that do not use water.

Wet shampooing is the usual method, using soap or shampoo and washing with water. The water temperature should be around 38℃. When hair is dry or damaged, warm hair oil is rubbed into the scalp before shampooing. This is called oil shampoo.

Dry shampoo is used for people who are bedridden for a long time or when water is not available, and is done with volatile liquids such as gasoline, alcohol, or hair tonic. After shampooing, rinse with cream rinse or acid rinse to give the hair shine. The most important factor in shampoo is cleansing power, but if the cleansing power is too strong, it will remove too much oil from the hair, so it is common to add a conditioner separately. There are neutral detergents made from petroleum or cetyl alcohol, detergents with lanolin (the fat of wool) or lecithin, a component of egg yolk, for dry or malnourished hair, detergents with vegetable oil, detergents with sterilizing properties, detergents for removing dandruff, and detergents for babies.

Meanwhile, ginseng is one of the herbal medicines that is widely studied around the world, and is known to contain saponins, phenol compounds, polyacetylenes, alkaloids, and polysaccharides. Ginseng is a perennial herb belonging to the genus Panax in the Araliaceae family, and its scientific name is Panax ginseng CAMeyer. Panaxa is a combination of pan, meaning everything, and Axos, meaning medicine, and it means ‘treating all diseases.’ Since it was discovered that the effective ingredient in ginseng is saponin, its pharmacological effects, such as anti-diabetic effects and improving cardiovascular disorders, have been elucidated, centered on saponin.

Saponins have been used as detergents and foaming agents since ancient times in South America and Europe, and are listed in the US FDA and the UK BP (British Pharmacopea), and are substances with excellent foaming power and confirmed safety. Among them, triterpenoid saponins are substances with excellent foaming power, with the hydrophilic part mainly composed of glucose, galactose, xylose, and rhamonose.

Ginseng saponin (ginsenoside) components can be divided into protopanaxidiol (PPD) ginsenosides (Rb1, Rb2, Rb3, Rc, Rd) and protopanaxatriol (PPT) ginsenosides (Re, Rf, Rg1, Rg2) based on their chemical structure. Ginsenosides belonging to the PPD family are effective in calming the central nervous system, sedation, anti-inflammation, and analgesic effects, while PPT ginsenosides are known to have effects such as recovering from fatigue, increasing exercise muscle strength, and reducing cholesterol.

Recently, soapless shampoos using synthetic detergents as the main ingredient have been released instead of detergents using soap as the main ingredient. Some of these have added suppressants such as cholesterol, lanolin, and glycerol to avoid removing too much sebum. They come in liquid and cream forms.

While the global movement to reduce the use of plastic products is gaining momentum, the number of plastic shampoo containers discarded worldwide is 552 million per year, and it is difficult to phase out plastics in the short term. This is why there is an urgent need for technology development for solid shampoos that do not require shampoo containers.

KR 10-2020-0070269 A

The purpose of the present invention is to provide a method for manufacturing a natural shampoo bar, which comprises a surfactant extracted from ginseng, wherein the surfactant contains saponin and exhibits activity of inhibiting inflammatory cell activation substances.

Another object of the present invention is to provide a natural shampoo bar that can improve and prevent dandruff or itchiness without side effects, including a surfactant extracted from ginseng.

In order to achieve the above object, a method for manufacturing a natural shampoo bar according to one embodiment of the present invention includes: 1) a surfactant manufacturing step of extracting a surfactant from ginseng; 2) a mixture manufacturing step of adding a natural extract to the ginseng extracted surfactant of step 1) and mixing them; 3) a heating step of heating the mixture of step 2) while stirring; 4) a solidification step of cooling and solidifying after the heating step of step 3); 5) a maturing step of maturing after the solidification step of step 4); and 6) a molding step of compression molding using a compressor PVC mold after the maturing step of step 5).

The above ginseng extract surfactant is characterized by containing saponin.

The above heating step is to stir and heat at 30 to 50°C.

The above maturation step is carried out at 5 to 35°C for 1 to 3 weeks.

The above natural extracts further include Fragaria orientalis extract, Carex nubigena var. albata extract, and Saussurea uchiyamana Nakai extract.

The above extract is extracted using an extraction solvent selected from the group consisting of water, lower alcohols having C ₁ to C ₆ and mixtures thereof.

According to another embodiment of the present invention, a natural shampoo bar is manufactured by the above-described manufacturing method.

Hereinafter, the present invention will be described in more detail.

Hereinafter, embodiments of the present invention will be described in detail so that those with ordinary knowledge in the technical field to which the invention of the present application belongs can easily practice it. The embodiments of the present invention are provided so that those with average knowledge in the art can more completely explain the present invention. Therefore, the embodiments of the present invention can be modified in various different forms, and the scope of the present invention is not limited to the embodiments described below.

The terminology used herein is for the purpose of describing embodiments only and is not intended to be limiting of the present invention. In this specification, the singular also includes the plural unless the context clearly dictates otherwise. The terms "comprise" and/or "comprising" as used herein do not exclude the presence or addition of one or more other components, steps, operations, and/or elements.

The term 'extract' used herein has the meaning commonly used in the art as a crude extract as described above, but in a broad sense, it also includes a fraction obtained by further fractionating an extract. That is, the plant extract includes not only one obtained by using the above-described extraction solvent, but also one obtained by additionally applying a purification process thereto. For example, fractions obtained by passing the extract through an ultrafiltration membrane having a certain molecular weight cut-off value, fractions obtained through various additional purification methods such as separation by various chromatographies (designed for separation according to size, charge, hydrophobicity, or affinity) are also included in the plant extract of the present invention.

The extract used in the present invention can be manufactured into a powder state by additional processes such as reduced pressure distillation and freeze drying or spray drying.

According to one embodiment of the present invention, a method for manufacturing a natural shampoo bar comprises: 1) a surfactant manufacturing step of extracting a surfactant from ginseng; 2) a mixture manufacturing step of adding a natural extract to the ginseng extracted surfactant of step 1) and mixing them; 3) a heating step of heating the mixture of step 2) while stirring; 4) a solidification step of cooling and solidifying after the heating step of step 3); 5) a maturing step of maturing after the solidification step of step 4); and 6) a molding step of compression molding using a compressor PVC mold after the maturing step of step 5).

The above step 1) is a step to extract surfactant from ginseng, and is intended to provide a natural shampoo bar that is harmless to the human body and environmentally friendly.

The above step 1) may further include a natural surfactant composed of disodium laureth sulfosuccinate, cocoamidopropyl betaine, cocodiethanolamide, sodium laureth sulfosuccinate, and an olive-based surfactant, but preferably includes a surfactant extracted from ginseng.

The above disodium laureth sulfosuccinate, also known as LES, is an anionic surfactant that is made from palm oil and succinic acid and increases viscosity. It has excellent foaming power and is hypoallergenic to the skin, so it is used in shampoos, skin care products, etc.

The above cocoamidopropyl betaine is called coco betaine and is a zwitterionic surfactant. It is a substance obtained from coconut oil and has a mild nature that does not irritate the skin mucosa when used in shampoos, shower gels, etc. When used with sodium lauryl sulfate (SLS), it can reduce irritation and increase viscosity, and as a cationic agent, it has antibacterial properties and an antistatic effect.

The above cocoamidopropyl betaine is a surfactant used as a viscosity-increasing detergent, foam stabilizer, and viscosity-forming agent made from palm oil fatty acids.

Meanwhile, olive surfactant is a surfactant manufactured by transforming olive oil, which is commonly used as olive liquid, into something that dissolves well in water and makes it blend well with water and oil.

Preferably, a natural shampoo bar containing a surfactant extracted from ginseng is manufactured, thereby providing a natural shampoo bar that is harmless to the human body and environmentally friendly.

The above step 2) is a process of adding a natural extract to the ginseng extract surfactant of step 1) and mixing them, and the natural extract of the present invention can provide a safe cleansing power to the skin or scalp.

The above step 3) is a step of heating while stirring the mixture of the ginseng extract surfactant and natural extract mixed in step 2), and is intended to increase the effect of the ginseng extract surfactant and natural extract mixing together.

The above heating step is a stirring heating step at 30 to 50°C. It is preferably performed at 30 to 35°C for 10 to 20 days, and the temperature range and period enhance the effect of mixing the ginseng extract surfactant and the natural extract, thereby facilitating the production of natural shampoo.

The above step 4) is a step for solidifying the mixture by cooling it after the heating step of step 3), and is a step for manufacturing a shampoo bar of solid shampoo that does not require a shampoo container.

The above 4) solidification step is different from the manufacturing process of making shampoo into a solid by condensing liquid shampoo, which is a conventional technology, or the manufacturing process of making general soap, and is a manufacturing process that compresses a surfactant rather than solidifying with a chemical solvent.

The above step 5) is a maturing step that follows the above solidification step 4), and is carried out at 5 to 35°C for 1 to 3 weeks.

The above temperature range and period are the temperature range and period for maintaining the solidified mixture, which is a step for ensuring that the mixture does not break easily and can be maintained in a certain shape during the manufacturing of the shampoo bar.

Additionally, a kneading step may be additionally included to evenly mix the ingredients during the maturing step.

Step 6) after the above 5) maturing step is a molding step that uses a compressor PVC mold to compress the solidified mixture, thereby maintaining it in a solid form once more, and is a step that can be molded into a desired shape according to the model of the PVC mold.

The above ginseng extract surfactant is characterized by containing saponin.

Ginseng is a perennial shade-loving herbaceous plant belonging to the genus Panax in the family Araliaceae in plant taxonomy, and has long been used as an important medicinal ingredient in oriental medicine. Ginseng is generally classified into white ginseng and red ginseng according to processing method. White ginseng is unprocessed ginseng dug from the field, that is, fresh ginseng that is dried as is, while red ginseng is fresh ginseng that is steamed and dried.

Ginseng is not only listed as a product in Shennongbonchogyeong, but has also been used as a valuable health supplement since ancient times. Through many pharmacological experiments to date, it has been revealed that ginseng enhances the body's non-specific resistance to stress and has an anti-acid effect. In addition, it has been revealed that it improves hypertension, enhances insulin action, lowers blood sugar in alloxan diabetic mice, promotes liver RNA synthesis, protein synthesis, sugar and lipid metabolism in rats, and has anticancer effects.

Ginseng has been used as a herbal medicine in Asian countries such as Korea, China, and Japan for various diseases such as psychiatric disorders, nervous system disorders, and diabetes. Saponin, the main component of ginseng, is known to have effects such as strengthening, tonic, sedation, hematopoiesis, and antihypertensive effects.

Ginseng is used in the form of white ginseng, which is made by drying fresh ginseng at room temperature as is, red ginseng, which is made by heat-treating fresh ginseng at 98 to 100°C, or fresh ginseng, which is made by heat-treating fresh ginseng at 120 to 180°C.

Ginseng roots contain approximately 5.22% of ginseng saponins, which are called ginsenosides. Ginseng is known to contain approximately 30 types of ginsenosides, which are broadly classified into diol types (panaxadiol, hereinafter referred to as "PD"), such as ginsenosides Rb1, Rb2, Rc, and Rd, and triol types (panaxatriol, hereinafter referred to as "PT"), such as ginsenosides Re, Rg1, and Rf. Diol (PD) ginsenosides and triol (PT) ginsenosides have opposing pharmacological effects, with diol (PD) ginsenosides having excellent efficacy in central nervous system sedation, and triol (PT) ginsenosides having excellent efficacy in central nervous system stimulation.

In particular, saponins have been used as detergents or foaming agents since ancient times in South America and Europe, and are substances with excellent foaming power and confirmed safety, and are also listed in the US FDA and the UK BP (British Pharmacopea). Among them, triterpenoid saponins are substances with excellent foaming power, whose hydrophilic portions are mainly composed of glucose, galactose, xylose, rhamonose, etc. Therefore, as described above, the ginseng extract surfactant according to the present invention has excellent foaming power.

In addition, the ginseng extract surfactant contains saponin, which forms a safe physical barrier on the skin or scalp, and protects the scalp safely and healthily from skin or scalp irritation such as itchiness, stinging, burning, inflammation, and erythema, and irritation and inflammation caused by dyeing, and soothes irritation.

Meanwhile, the scalp also excretes harmful substances and waste products from the body. When dead skin cells and waste products mix with sebum and accumulate on the surface of the scalp, they can block the pores of the scalp, causing inflammation and thinning of the hair.

The present invention shows activity of suppressing inflammatory cell activation substances by containing saponin through the ginseng extract surfactant.

Accordingly, the shampoo bar of the present invention can provide a natural shampoo bar that washes away sebum, sweat, dead skin cells, waste products, dust, etc. accumulated on the scalp, and at the same time suppresses inflammatory cell activators without side effects, thereby improving and preventing dandruff and itchiness.

The above natural extracts further include Fragaria orientalis extract, Carex nubigena var. albata extract, and Saussurea uchiyamana Nakai extract.

If the above natural extracts are further included, it can exhibit excellent cleansing effects while preventing the natural oils essential to the scalp from being removed.

The above-mentioned Fragaria orientalis is a diploid species of wild strawberry native to East Asia and Siberia, and its fruit ripens to a purple-red color with deeply inserted ovoid achenes.

The above Carex nubigena var. albata is a perennial herb of the Cyperaceae family in the Poaceae order of monocotyledons, and grows in mountains and fields. The rhizome is short, and the stem is thin and long, triangular, and grows in clumps and stands upright. It is about 30 cm tall. The leaves grow in clumps and are linear, with pointed tips. The leaves are shorter or longer than the stem and are about 3 mm wide. The flowers bloom from April to June. The inflorescence is erect at the end of the stem, cylindrical, and about 25 to 40 mm long. There are short linear bracts at the base, and the spikelets are bisexual and about 5 mm long. The female inflorescence is egg-shaped, pointed at the tip, and brown. The fruit sac is egg-shaped lanceolate, 4 to 5 mm long, longer than the inflorescence, and has two styles. It is distributed in Jeollabuk-do, Gyeonggi-do, Pyeongannam-do, Pyeongannam-do, Hamgyeongnam-do, and Hamgyeongbuk-do.

Saussurea uchiyamana Nakai is a perennial herb of the Asteraceae family in the Campanulate order of dicotyledons, growing in mountain forests. The leaves that grow from the roots remain until the flowers bloom, spread out like a rose, are egg-shaped or oblong, and have pointed tips. They are 11 to 20 cm long and 7 to 9.5 cm wide, have slightly curly hairs on the surface, and have cobweb-like hairs on the back and sharp teeth on the edges. The leaves that grow from the stem are similar to those that grow from the roots, but are different in size.

Preferably, the natural shampoo bar of the present invention contains 10 to 20 parts by weight of an extract of Dongbangchomae, 10 to 20 parts by weight of an extract of Dorangi sacho, and 10 to 20 parts by weight of an extract of Sharon rhizome per 100 parts by weight of a ginseng extract surfactant.

When mixed within the above weight range, it is most suitable for use as a final manufactured natural shampoo bar and can have excellent cleansing power for the scalp. In particular, it can maintain the natural oils essential to the scalp.

In addition, if the weight range above is exceeded, excessive stimulation to the scalp may occur, which may cause adverse effects such as inflammation.

The above extract is extracted using an extraction solvent selected from the group consisting of water, alcohols having 1 to 6 carbon atoms, and mixtures thereof.

Specifically, in order to prepare an extract, a natural extract can be obtained, including a step of washing a natural material; a step of drying after washing; a step of pulverizing the natural material after drying; a step of extracting the pulverized material using an organic solvent; a step of drying the sample after extracting; a step of extracting using water; and a step of extracting.

The natural extract extracted using the above organic solvent may further include a step of performing fractionation using an organic solvent.

The method for producing the above extract may be a conventional extraction method in the art, such as an ultrasonic extraction method, an infusion method, and a reflux extraction method. Specifically, it may be an extract obtained by removing foreign substances from a natural product by washing and drying, and extracting it with water, an alcohol having 1 to 6 carbon atoms, or a mixed solvent thereof, and it may be an extract obtained by sequentially applying the above solvents to a sample.

The above reflux extraction method is performed using 10 to 30 g of a pulverized natural product, 1 to 3 hours of reflux time, and 50 to 100% of alcohol having 1 to 6 carbon atoms or water, based on 100 mL of water and alcohol having 1 to 6 carbon atoms. More specifically, it is performed using 10 to 20 g of a pulverized natural product, 1 to 2 hours of reflux time, and 70 to 90% of alcohol having 1 to 4 carbon atoms or water, based on 100 mL of water or alcohol having 1 to 6 carbon atoms.

The above extraction method is carried out at 15 to 30°C for 24 to 72 hours, and uses water or 50 to 100% alcohol having 1 to 6 carbon atoms as an extraction solvent. More specifically, it is carried out at 20 to 25°C for 30 to 54 hours, and the extraction solvent is water or 70 to 80% alcohol having 1 to 6 carbon atoms.

The above ultrasonic extraction method is carried out at 30 to 50°C for 0.5 to 2.5 hours, and the extraction solvent is water or an alcohol having 1 to 6 carbon atoms at 50 to 100%. Specifically, the extraction is carried out at 40 to 50°C for 1 to 2.5 hours, and the extraction solvent is water or an alcohol having 1 to 6 carbon atoms at 70 to 80%.

The above extraction solvent can be used in an amount of 2 to 50 times the weight of the sample, more specifically 2 to 20 times. For extraction, the sample can be left in the extraction solvent for 1 to 72 hours, more specifically 24 to 48 hours.

After extraction, the extract can be fractionated by sequentially applying a new fractionation solvent. The fractionation solvent used in the fractionation is at least one selected from the group consisting of water, hexane, butanol, ethyl acetate, ethyl acetate, methylene chloride, and mixtures thereof, and is preferably ethyl acetate or methylene chloride.

After obtaining the extract or fraction, additional methods such as concentration or lyophilization can be used.

According to another embodiment of the present invention, a natural shampoo bar is manufactured by the above-described manufacturing method.

Hereinafter, the present invention will be described in more detail through examples. These examples are only intended to illustrate the present invention, and therefore, the scope of the present invention is not to be construed as being limited by these examples.

The natural shampoo bar comprising a ginseng-extracted surfactant and the method for producing the same according to the present invention comprises a surfactant extracted from ginseng, and the surfactant contains saponin, thereby exhibiting an activity of suppressing inflammatory cell-activating substances, thereby providing a natural shampoo bar capable of improving and preventing dandruff or itchiness without side effects.

Figure 1 shows the results of a cleaning power test before and after use of a natural shampoo bar manufactured according to one embodiment of the present invention.
Figure 2 illustrates a method for manufacturing a natural shampoo bar according to one embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein.

[Manufacturing Example 1: Manufacturing of Ginseng Extract Surfactant]

1. Preparation of ginseng extract surfactant

10 kg of ginseng root was cut into small pieces and soaked in 8 L of 80% aqueous MeOH and left at room temperature for 2 days, and this extraction method was repeated twice. The extracts were combined and concentrated in vacuo to obtain 540 g of residue. 100 g of the residue was chromatographed on a C18 silica gel flash column using MeOH in _H2O (4 L each) as an eluent in 10% increments from 0 to 100% to obtain fractions. The active fractions were combined and chromatographed again on silica gel color to obtain the final fraction.

Afterwards, the ginseng root was pressed to extract oil, and the raw material was dried at 50℃ for 12 hours using a high-temperature dryer (model name; Sanyo Mov-212F).

Dried ginseng roots were ground through a grinder and irradiated with gamma rays for 10 hours to produce a ginseng extract surfactant (GES) that increases the preservative power of the ground ginseng root.

[Manufacturing Example 2: Manufacturing of Natural Shampoo Bar]

1. Preparation of natural extracts

After drying the oriental medicinal herb naturally, the oriental medicinal herb was ground in a blender with its skin to make a powder. Afterwards, 95% concentration ethanol was mixed and extracted at 70℃ for 5 hours.

The above extract was filtered through Whatman NO.2 (Whatman Ltd., UK) to obtain a liquid component, and the liquid component was concentrated by applying it to a vacuum evaporator to obtain the extract of Dongbangchomae (FE).

2. Preparation of other extracts

Using the same method as the above method for producing the extract of the oriental medicinal herb (FE), the extract of the Chinese chive (AE) and the extract of the common chive (CE) were produced.

3. Manufacturing of natural shampoo bars

The above ginseng extract surfactant (GES) and natural extracts of Dongbangchomae extract (FE), Dorangi sacho extract (AE), and Haemulsae extract (CE) were mixed within the weight ranges shown in Table 1 below.

SP1 SP2 SP3 SP4 SP5 GES 100 100 100 100 100 FE - 5 10 20 25 AE - 5 10 20 25 CE - 5 10 20 25

(Unit: parts by weight)

A mixture (SP1 to SP5) of the extract of Dongbangchomae (FE), the extract of Dorangi Sacho (AE), and the extract of Haemulsae (CE) mixed with the above ginseng extract surfactant (GES) was heated with stirring at 35°C for 20 days.

Afterwards, the stirred and heated mixture was cooled and solidified without using any chemical solvent.

The above solidified mixture was aged at 35°C for 3 weeks, and then compression molded using a circular compressor PVC mold to produce natural shampoo bars SPB1 to SPB5 of the present invention.

[Experimental Example 1: Foaming Power Test of Natural Shampoo Bar]

In order to determine the foaming power according to the use of natural shampoo bars SPB1 to SPB5 manufactured in the above manufacturing example 2, a foaming power test was conducted according to the following method.

The measurement was performed using a SITA R-2000 foam meter (a device that generates foam using a rotor and then measures the height of the foam), and the measurement method was as follows: 5 g each of the natural shampoo bars SPB1 to SPB5 and 200 g of tap water were used to make 205 g of natural shampoo bar sample solutions SPB'1 to SPB'5, and then 0.1 g of artificial sebum solution was dropped and mixed.

The results are shown in Table 2 below, and represent the average value after repeating the experiment three times.

In addition, ammonium lauryl sulfate (ALS), a sulfate-based surfactant commonly used as a detergent, was used as a comparative example, and the foaming power was measured using the same method as in the above experiment.

Comparative example (ALS) SPB'1 SPB'2 SPB'3 SPB'4 SPB'5 Bubble height 652 657 666 712 724 659

(Unit: mm)

As can be seen from Table 2 above, the sample solution SPB'1 of shampoo bar SPB1 containing the ginseng extract surfactant (GES) of the present invention showed foaming power very similar to that of ammonium lauryl sulfate (comparative example).

In particular, it was confirmed that sample solutions SPB'2 to SPB'5 further containing dongbangchomae extract (FE), dorangi grass extract (AE), and yam extract (CE) in addition to ginseng extract surfactant (GES) exhibited better foaming power than the comparative examples. Therefore, by mixing and using the ginseng extract surfactant and natural extract of the present invention, a detergent with high cleaning power can be manufactured.

[Experimental Example 2: Anti-inflammatory activity test of natural shampoo bar]

In an anti-inflammatory experiment of the natural shampoo bars SPB1 to SPB5 of the present invention, the secretion amounts of IL-1β and TNF-α cytokines in the cell culture solution of peritoneal macrophage cell lines were measured using an ELISA kit (Mouse ELISA set, BD Bioscience, San Diego, CA, USA).

Then, peritoneal macrophages were pretreated with SPB1 to SPB5, a natural shampoo bar containing a ginseng extract surfactant according to Manufacturing Example 2, at various concentrations, stimulated with LPS (1), and then cultured for 48 hours.

Natural shampoo bars SPB1 to SPB5 containing ginseng extract surfactants were quantitatively measured at a concentration of 30 mg/ml in 100% ethanol, and then the ethanol was evaporated.

The supernatant was injected with an equal amount of Griess reagent (1% sulfanilamide, 0.1% N-(1-naphthyl)-ethylene diamine dihydrochloride in 2.5% phosphoric acid solution) and left at room temperature for 10 minutes.

The absorbance of the result was measured at 540 nm using a microlate reader.

Blank Comparative example (LPS) SPB1 SPB2 SPB3 SPB4 SPB5 NO production 10 75 62 54 23 18 52

(Unit: μm)

As can be seen in Table 3 above, the experimental results demonstrated that natural shampoo bars SPB1 to SPB5 according to Manufacturing Example 2 had high anti-inflammatory activity as shown in Table 3 above.

In particular, among the natural shampoo bars SPB2 to SPB5 containing more natural extracts, it was confirmed that the natural shampoo bars showed a higher anti-inflammatory activity effect when containing natural extracts by SPB3 to SPB4 compared to the comparative example of toxic substance (LPS).

[Experimental Example 3: Sensory Test]

1. Dandruff reduction rate

Twenty people who usually suffer from relatively frequent scalp itching and dandruff were selected and had them use the natural shampoo bars SPB1 to SPB5 manufactured in Manufacturing Example 2 for one month.

Before the start of the experiment, the weight of dandruff accumulated for 3 days was collected by washing the hair with the same regular shampoo (comparative example), and the weight of dandruff accumulated for 3 days after 1 month by washing the hair once a day with the natural shampoo bars SPB1 to SPB5 manufactured in the above-mentioned manufacturing example 2 (B) was compared and evaluated.

Dandruff reduction rate (%) = [(Dandruff weight before test (A) (mg) - Dandruff weight 1 month after test (B) (mg)) / Dandruff weight before test (A) (mg)] × 100

The results are shown in Table 4 below.

2. Effective in relieving scalp itchiness

The above 20 subjects washed their hair once a day with the natural shampoo bars SPB1 to SPB5 manufactured in Manufacturing Example 2, and after one month, each experimental item was evaluated according to the 5-point scoring system below.

< 5-point grading system >

1 point: Scalp itchiness worsened.

2 points: I don't know.

3 points: Average.

4 points: Good.

5 points: Very good.

The evaluation results for each item are the average values of the 20 subjects, and the results are shown in Table 4 below.

Comparative example SPB1 SPB2 SPB3 SPB4 SPB5 Dandruff reduction rate 22.1 48.7 50.2 55.6 58.4 50.9 Scalp itching level 60.2 70.2 77.5 85.6 88.0 78.6

(unit: %)

As can be seen from Table 4 above, when the natural shampoo bars SPB1 to SPB5 of the present invention were used, it was confirmed that they showed very excellent evaluations in terms of the dandruff reduction rate and scalp itchiness elimination degree compared to when the comparative shampoo was used.

In particular, it was confirmed that excellent effects were exhibited when shampoo bars SPB2 to SPB5 further containing ginseng extract surfactant (GES) plus oriental ginseng extract (FE), dandelion grass extract (AE), and eucommia ulmoides extract (CE) were used.

3. Sensory evaluation

In order to determine the effects of shampoo bars SPB1 to SPB5 manufactured according to Manufacturing Example 2 of the present invention, a sensory evaluation was conducted. Twenty participants who had family members who were concerned about hair loss or sensitive scalps participated in the evaluation.

The evaluation was conducted for 4 weeks, and the subjects used regular shampoo (comparative example) for 2 weeks and the natural shampoo bar (SPB1 to SPB5) of Manufacturing Example 2 for 2 weeks. The subjects washed their hair once a day using the shampoo and shampoo bar, and checked the amount of hair loss.

The evaluation was conducted using a 5-point scale, and included evaluation of scalp heat, hair loss, hair softness after shampooing, and cleansing power.

The results are shown in Table 5 below, and a higher score indicates less scalp heat, less hair loss from the scalp, softer hair, and better cleansing power.

Evaluation items Comparative example SPB1 SPB2 SPB3 SPB4 SPB5 Scalp fever 2.16 3.23 3.55 4.21 4.56 4.01 Hair loss 2.01 3.11 3.32 4.20 4.65 3.86 Softness 2.97 3.05 2.84 3.62 4.03 3.11 Cleaning power 2.10 3.16 3.22 4.01 4.52 3.59

(Unit: Index)

As can be seen from Table 5 above, the natural shampoo bars SPB3 to SPB4 of the present invention received the best evaluations. Next, the natural shampoo bars SPB1, SPB2, and SPB5 received good evaluations, while the comparative example, which was a shampoo previously used by the participants, received poor evaluations.

Additionally, according to the opinions of the participants, there were responses that when using the natural shampoo bar of the present invention, less hair loss occurred and the hair felt softer after shampooing.

In addition, when using shampoo bars of SPB3 or SPB4, participants who had scalp heat responded that the scalp heat was reduced, and participants who had sensitive scalp discomfort also responded that their scalp became more comfortable.

Additionally, to test the cleansing power of the natural shampoo bar SPB4 of the present invention, which exhibited the above-mentioned excellent effects, a waterproof eyeliner was applied to the scalp of a normal wig, washed with the natural shampoo bar SPB4 of the present invention, and the cleansing power was observed through an electron microscope.

The results are shown in Figure 1 below. The photo on the left shows an unwashed wig, showing waterproof eyeliner, while the photo on the right shows a wig washed with the natural shampoo bar SPB4 of the present invention, magnified 600 times to confirm its excellent cleaning power.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concept of the present invention defined in the following claims also fall within the scope of the present invention.

Claims (7)

1) A surfactant manufacturing step for extracting a surfactant containing saponin from ginseng;
2) Mixture preparation step of adding natural extract to the ginseng extract surfactant of step 1) above and mixing:
3) A heating step of heating the mixture of step 2) while stirring;
4) A solidification step of cooling and solidifying after the heating step of step 3);
5) A maturing step that is performed after the solidification step of 4) above; and
6) A molding step of performing compression molding using a compressor PVC mold after the maturation step of the above 5);
The above natural extracts include extracts of Fragaria orientalis, Carex nubigena var. albata, and Saussurea uchiyamana Nakai.
How to make a natural shampoo bar. delete In the first paragraph,
The above 3) heating step is to stir and heat at 30 to 50°C.
How to make a natural shampoo bar. In the first paragraph,
The above 5) maturation step is carried out at 5 to 35℃ for 1 to 3 weeks.
How to make a natural shampoo bar. delete In paragraph 1.
The above extract is extracted using an extraction solvent selected from the group consisting of water, lower alcohols of C ₁ to C ₆ , and mixtures thereof.
How to make a natural shampoo bar. Manufactured by a manufacturing method according to any one of Articles 1, 3, 4 and 6
Natural shampoo bar.