KR102271530B1 - 리포테이코익산 유래 당지질을 포함하는 암 예방 및 치료용 약학적 조성물 - Google Patents
리포테이코익산 유래 당지질을 포함하는 암 예방 및 치료용 약학적 조성물 Download PDFInfo
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- KR102271530B1 KR102271530B1 KR1020180173590A KR20180173590A KR102271530B1 KR 102271530 B1 KR102271530 B1 KR 102271530B1 KR 1020180173590 A KR1020180173590 A KR 1020180173590A KR 20180173590 A KR20180173590 A KR 20180173590A KR 102271530 B1 KR102271530 B1 KR 102271530B1
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Abstract
Description
도 2는 L. plantarum LTA의 COSY 스펙트럼을 나타낸다.
도 3은 L. plantarum LTA의 HMQC 스펙트럼을 나타낸다. (A: 올레핀 탄소에 연결된 α-메틸렌과 메틸렌, B: α-D-갈락토스와 α-D-글루코스의 아노머 양성자)
도 4는 LTA 가수분해물의 GC/MS 분석결과를 나타낸다.
도 5는 LTA 당지질의 MALDI-TOF MS 스펙트럼을 나타낸다. (A: S aureus, B: L. plantarum)
도 6은 (A) aLTA 및 (B) pLTA의 intact 당지질 및 O-아세틸화된 당지질의 MALDI-TOF MS 스펙트럼을 나타낸다.
도 7은 pLTA의 당지질의 구조를 나타낸다.
도 8은 pLTA 당지질의 질량을 분석한 표를 나타낸다.
도 9는 (A) aLTA 당지질 및 (B) pLTA 당지질의 LTQ-Orbitrap FTMS 스펙트럼을 나타낸다.
도 10은 LTA 당지질의 음이온 CID 스펙트럼을 나타낸다. (A: 다이헥소실-다이아실-글리세롤, B: 트리헥소실-다이아실-글리세롤)
도 11은 aLTA 당지질의 질량을 분석한 표를 나타낸다.
도 12는 aLTA의 탈아실화된 당지질의 MALDI-TOF MS 스펙트럼을 나타낸다.
(a: intact 당지질, b: NaOH 처리한 당지질, c: Ca(OH)2 처리한 당지질)
도 13은 pLTA, dLTA, rLTA 및 sLTA의 당지질 부위에 대한 MALDI-TOF 분석 결과를 나타낸다.
도 14는 리포테이코익산 유래 당지질에 의한 대장암 세포의 자가 사멸유도 분석한 결과를 나타낸다:
TI only: TNF-α+IFN-γ
Intact pLTA: 리포테이코익산에 변형을 주지 않은 것
phosphate chain: NaOH를 처리한 후 분리한 것
glycolipid: Tris HCl pH 8.0으로 처리한 후 분리한 당지질.
Claims (18)
- 하기 화학식 I의 구조를 갖는 당지질을 포함하는 암 예방 또는 치료용 약학적 조성물.
[화학식 I]
(상기 화학식 I에서,
X1는 C15 내지 C19의 직쇄 알킬이고, 여기서 상기 C15 내지 C19의 직쇄 알킬은 1 내지 5의 불포화 결합을 포함할 수 있고;
X2는 C15 내지 C19의 직쇄 알킬이고, 여기서 상기 C15 내지 C19의 직쇄 알킬은 1 내지 5의 불포화 결합을 포함할 수 있고;
R4는 하이드록시 또는 -O(C=O)X3이고, 상기 X3는 C12 내지 C16의 직쇄 알킬이고, 여기서 상기 C12 내지 C16의 직쇄 알킬은 1 내지 5의 불포화 결합을 포함할 수 있다.)
- 제 1항에 있어서,
상기 암은 대장암, 간암, 위암, 폐암, 유방암, 직장암, 췌장암 또는 혈액암인 것을 특징으로 하는 약학적 조성물.
- 제 1항에 있어서,
X1는 C16 내지 C18의 직쇄 알킬이고;
X2는 C16 내지 C18의 직쇄 알킬이고, 여기서 상기 C16 내지 C18의 직쇄 알킬은 1 내지 3의 불포화 결합을 포함할 수 있고;
R4는 하이드록시 또는 -O(C=O)X3이고, 상기 X3는 C13 내지 C15의 직쇄 알킬인 것을 특징으로 하는 약학적 조성물.
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- 제 1항의 조성물에 TNF-α 및 IFN-γ를 추가적으로 포함하는 암 예방 또는 치료용 약학적 조성물.
- 제 15항에 있어서,
상기 암은 대장암, 간암, 위암, 폐암, 유방암, 직장암, 췌장암 또는 혈액암인 것을 특징으로 하는 약학적 조성물.
- 제 1항의 조성물에 TNF-α 및 IFN-γ를 추가적으로 포함하는 항암 보조제.
- 제 1항의 조성물에 TNF-α 및 IFN-γ를 추가적으로 포함하는 암 예방 또는 개선용 건강기능식품.
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Non-Patent Citations (2)
Title |
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Arch Dig Disord, Vol. 1, No. 1, pp. 22-27 (2017)* |
The Oncologist, Vol. 11, pp. 397-408 (2006)* |
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