KR102174568B1 - Stamp type microstructure applicator - Google Patents

Abstract

A stamp type microstructure applicator is provided. The stamp type microstructure applicator according to an embodiment of the present invention includes: a microstructure module provided with a microstructure including a first chemical; a main body in which the microstructure module is coupled to the lower side to insert the microstructure into the skin through external force by a user; and a liquid supply unit provided on the upper side of the main body and supplying a second liquid chemical to the microstructure module side, wherein the second liquid chemical is applied to the skin after the microstructure is implanted into the skin to promote at least one of skin penetration, dissolution, diffusion and absorption into the skin of the microstructure.

Description

Stamp type microstructure applicator

The present invention relates to a stamp-type microstructure applicator.

In general, oral administration of a tablet or capsule form or a needle is used to deliver a drug for treatment or cosmetic treatment in the body. Recently, various microstructures including microneedles have been developed. Microstructures developed to date have been mainly used for drug delivery in vivo, blood collection, and detection of analytes in the body.

Inserting a conventional biodegradable microneedle into the skin is largely two types, using a patch form and an applicator. However, in the case of the patch type, skin irritation caused by attachment and detachment of the patch, human hair pushes the patch out of the skin where human hair exists, and the microneedle insertion rate decreases, which is caused by interfering with the patch-skin adhesion, and wrinkles or joints. Problems such as difficulty of attaching patches occurred in areas where there is a curvature or movement of the skin, such as in the area. In addition, in the case of the applicator, the form of shooting a microneedle using an elastic force is mainly formed, and at this time, pain may be caused to the skin by the shooting force.

On the other hand, biodegradable drugs contained in microneedles are inserted into the skin and dissolved, taking tens of minutes from moisture, so there is a high possibility that the drug will leak out of the skin due to external factors before the drug is absorbed into the skin. The absorption efficiency is not high.

In order to solve this problem, there is an increasing need for an applicator for simultaneously using a drug that facilitates penetration of the microstructure into the skin while reducing pain when inserting the microstructure into the skin.

KR 1782752 B1

In order to solve the problems of the prior art as described above, an embodiment of the present invention is to provide a stamp-type microstructure applicator capable of promoting the action of the microstructure in the skin while reducing pain during use.

According to an aspect of the present invention for solving the above problems, a microstructure module provided with a microstructure including a first drug; A main body coupled to the lower side of the microstructure module to insert the microstructure into the skin by an external force by a user; And a liquid supply unit provided on the upper side of the body and supplying a liquid second drug to the microstructure module side, wherein the liquid second drug is applied on the skin after the microstructure is implanted on the skin. A stamp-type microstructure applicator is provided that promotes at least one of skin penetration, dissolution, diffusion in the skin, and absorption into the skin of the microstructure.

In one embodiment, the microstructure module includes a plate-shaped support plate in which a through hole coupled to the body is provided in the center, and microprotrusions protrude downward at a predetermined interval, and the microstructure includes the microprotrusions It can be formed on.

In one embodiment, the liquid second drug may flow out through the through hole and flow through the first flow path formed by the microprotrusions to be applied to the skin.

In one embodiment, the support plate may have a second flow path orthogonal to the through hole therein, and the second flow path may communicate with the spaces of the fine projections.

In one embodiment, the main body is a handle for the user to hold; A seating part provided inside the handle part to which the liquid supply part is mounted; A plate-shaped support portion protruding downward from the coupling portion to which the microstructure module is coupled; An extension part extending the support part and the handle part; And a flow path portion formed from the seating portion to the coupling portion and through which the liquid second drug flows.

In one embodiment, the flow path portion may be formed in a vertical type, a horizontal zigzag type, a straight type or a curved shape inside the body.

In one embodiment, the seating portion may have a shape corresponding to the shape of the liquid supplying portion.

In one embodiment, the outer diameter of the coupling portion may be substantially the same as the inner diameter of the penetrating portion of the microstructure module.

In one embodiment, the microstructure module may be coupled to the main body by a force fitting method.

In one embodiment, the liquid supply unit includes a receiving unit for receiving the liquid second drug; And a withdrawal part for flowing the liquid second drug through the body.

In one embodiment, the receiving portion may flow the liquid second drug to the withdrawal portion in a dropper manner.

In one embodiment, the liquid second drug may be repeatedly supplied at predetermined time intervals.

In one embodiment, the liquid second drug may contain at least one of minoxidil, triamcinolone, and finasteride.

In one embodiment, at least a portion of the receiving portion may be provided to protrude outward of the body.

In one embodiment, the liquid supply unit may be provided integrally with the body.

In one embodiment, the liquid supply unit may be detachably provided on the main body.

In the stamp-type microstructure applicator according to an embodiment of the present invention, after the microstructure is inserted into the skin, a secondary drug for assisting the action of the microstructure is injected, thereby promoting penetration, dissolution, diffusion, and absorption of the microstructure. Therefore, the efficacy of drug delivery can be improved.

In addition, in the stamp-type microstructure applicator according to an embodiment of the present invention, since the microstructure is inserted into the skin by the user's pressing force, the user's pain can be reduced, thereby improving the user's convenience.

1 is a perspective view of a stamp-type microstructure applicator according to an embodiment of the present invention,
Figure 2 is an exploded perspective view of Figure 1,
3 is a cross-sectional view of the main body of FIG. 1;
Figure 4 is a perspective view of the main body of Figure 1,
5 is a cross-sectional view of an example of the microstructure module of FIG. 1;
6 is a cross-sectional view of another example of the microstructure module of FIG. 1;
7 is a cross-sectional view showing a state in which a microstructure is inserted into the skin by a stamp-type microstructure applicator according to an embodiment of the present invention, and,
8 is a cross-sectional view illustrating a state in which a second drug is applied to the skin after FIG. 7.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those of ordinary skill in the art can easily implement the present invention. The present invention may be implemented in various different forms, and is not limited to the embodiments described herein. In the drawings, parts irrelevant to the description are omitted in order to clearly describe the present invention, and the same reference numerals are assigned to the same or similar components throughout the specification.

Hereinafter, a stamp-type microstructure applicator according to an embodiment of the present invention will be described in more detail with reference to the drawings. 1 is a perspective view of a stamp-type microstructure applicator according to an embodiment of the present invention, Figure 2 is an exploded perspective view of FIG.

1 and 2, the stamp-type microstructure applicator 100 according to an embodiment of the present invention includes a liquid supply unit 110, a body 120, and a microstructure module 130.

The stamp-type microstructure applicator 100 is for implanting the microstructure of the microstructure module 130 into the skin by an external force by a user. Here, the "external force" is a pressing force by a user, and may be a force that presses the stamp-type microstructure applicator 100 in the skin direction. In addition, the external force may be an external force by a mechanical device.

As a result, the user's pain can be reduced compared to the conventional shooting device, and thus the user's convenience can be improved.

In this case, the microstructure may include the first drug. The first drug used for the microstructure in the present invention is not particularly limited. For example, the drug may include chemical drugs, protein drugs, peptide drugs, nucleic acid molecules for gene therapy, nanoparticles, functional cosmetic active ingredients and cosmetic ingredients.

Further, in the present invention, the material forming the microstructure includes a biocompatible or biodegradable material. As used herein, the term "biocompatible substance" refers to a substance that is not toxic to the human body, is chemically inactive, and is not immunogenic. In the present specification, the term "biodegradable material" refers to a material that can be degraded by body fluids or microorganisms in a living body.

In this case, the microstructure may be formed by spotting the viscous composition of drugs as described above. Here, the term "viscous composition" refers to a composition having the ability to form a microstructure by changing the shape.

In addition, the stamp-type microstructure applicator 100 supplies a second drug 116 for promoting the action of the microstructure through the liquid supply unit 110. Here, the action of the microstructure refers to a series of processes in which the microstructure penetrates and dissolves in the skin, and is diffused and absorbed in the skin.

In addition, the second drug 116 may be a liquid drug applied to the skin. However, the present invention is not limited thereto, and the second drug 116 may not include a specific drug and may include only a solvent. For example, the liquid second drug 116 may include at least one of minoxidil, triamcinolone, and finasteride.

The liquid second drug 116 is applied to the skin after the microstructure is implanted into the skin to promote at least one of skin penetration, dissolution, diffusion into the skin, and absorption of the microstructure.

Accordingly, since the microstructures are inserted into the skin and help the action of the microstructures, the efficacy of drug delivery contained in the microstructures can be improved.

The liquid supply unit 110 is provided on the upper side of the main body 120 and supplies a liquid second drug 116 to the microstructure module 130. In this case, the liquid supply unit 110 may be detachably provided on the main body 120. That is, the liquid supply unit 110 may be provided separately from the main body 120. Alternatively, the liquid supply unit 110 may be provided integrally with the body 120.

In the main body 120, the microstructure module 130 is coupled to the lower side to insert the microstructure into the skin by an external force by a user. Here, the main body 120 may be a part that the user holds and applies a force. In this case, the main body 120 may deliver the liquid second drug 116 supplied from the liquid supply unit 110 to the microstructure module 130.

The microstructure module 130 is provided with a microstructure including a first drug. Here, the microstructure module 130 may be a part that is in close contact with the user's skin. In this case, the microstructure module 130 may flow to apply the liquid second drug 116 supplied through the main body 120 from the liquid supply unit 110 to the skin.

More specifically, referring to FIGS. 1 and 2, the liquid supply unit 110 may include a receiving unit 112 and a drawing unit 114.

The accommodating part 112 may accommodate the liquid second drug 116. The receiving part 112 may have a certain receiving space. For example, the receiving part 112 may be formed in an elliptical shape. At this time, the receiving part 112 may flow the liquid second drug 116 to the withdrawal part 114 in a dropper manner.

To this end, at least a portion of the receiving part 112 may be provided to protrude outward of the body 120. That is, when the user presses the receiving unit 112 using the protruding portion of the receiving unit 112, the liquid second drug 116 accommodated in the receiving unit 112 will flow through the withdrawal unit 114. I can.

Here, the liquid second drug 116 may be supplied in full amount at one time or divided and supplied several times. For example, when the liquid second drug 116 is dividedly supplied, it may be repeatedly supplied at predetermined time intervals. That is, by using the dropper method, the receiving unit 112 may supply the liquid second drug 116 at a constant parallax interval.

Accordingly, by supplying the liquid second drug 116 at regular time intervals according to the action step of the microstructure inserted into the skin, the effect of the microstructure can be improved.

In addition, the receiving unit 112 may be configured to be sealed when the liquid supply unit 110 is configured separately from the main body 120, that is, when the liquid supply unit 110 is a replaceable type. Although not shown in the drawing, when the liquid supply unit 110 is integrally formed with the main body 120, the receiving unit 112 may include an injection port for injecting the liquid second drug 116.

The lead portion 114 may be formed to extend from the lower side of the receiving portion 112. At this time, the withdrawal part 114 may flow the liquid second drug 116 through the main body 120.

Here, the receiving portion 112 and the lead portion 114 may be integrally formed. In this case, the liquid supply unit 110 may be made of a soft material to supply the liquid second drug 116 in a dropper manner. For example, the liquid supply unit 110 may be made of a polyethylene material.

3 is a cross-sectional view of the main body of FIG. 1, and FIG. 4 is a perspective view of the main body of FIG. 1.

The body 120 may include a handle portion 121, an extension portion 122, and a support portion 123. Here, the main body 120 may have an approximately stamp shape. That is, in the main body 120, the handle portion 121 is formed to be convex, the extension portion 122 is formed to be concave, and the support plate 131 may be formed flat from the extension portion 122.

The handle part 121 is a part for the user to grasp. In addition, the handle portion 121 may be provided with a seating portion 125 for mounting the liquid supply unit 110 therein. Here, the seating unit 125 may have a shape corresponding to the shape of the liquid supply unit 110.

In addition, the handle portion 121 may be formed in a cylindrical shape so that the liquid supply unit 110 is mounted at the same time while being easy for the user to grasp.

At this time, the seating portion 125 may be provided with protrusions 126 at regular intervals on the inner wall surface thereof. The protrusion 126 may be in close contact with the receiving part 112 of the liquid supplying part 110. In addition, a certain space may be formed between the protrusion 126 and the protrusion 126.

Accordingly, when the shape of the receiving portion 112 is pressed and the shape is deformed, the deformed portion is accommodated between the protrusions 126, so that the receiving portion 112 is operated in an eyedropper manner, and the protruding portion 126 is It can help to maintain the shape of 112.

In addition, when the liquid supply unit 110 in which the liquid second drug 116 is accommodated is mounted on the receiving unit 125, by reducing the contact area between the inner side of the receiving unit 125 and the receiving unit 112, The frictional force between the inner surface of the part 125 and the outer surface of the receiving part 112 is reduced, so that the receiving part 112 may be smoothly mounted on the seating part 125.

The extension part 122 may extend from the handle part 121 to the support part 123. Here, the extension part 122 may be formed to be concave compared to the handle part 121. That is, the diameter of the extension part 122 may be smaller than the diameter of the handle part 121.

The support part 123 may be formed in a plate shape perpendicular to the extension part 122. Here, the support part 123 may be a part to which the microstructure module 130 is coupled. In this case, the support part 123 may be formed radially from the extension part 122. That is, the extension part 122 may be disposed in the center of the support part 123. In addition, the support part 123 may be formed in a shape corresponding to the planar shape of the microstructure module 130.

In addition, the support part 123 may have a coupling part 124 to which the microstructure module 130 is coupled to protrude under the support part 123. Here, the coupling part 124 may be disposed in the center of the support part 123. In addition, the coupling portion 124 may be formed in a circular shape.

Here, the outer diameter of the coupling part 124 may be substantially the same as the inner diameter of the through hole 134 of the microstructure module 130. Accordingly, the microstructure module 130 may be coupled to the main body 120 in a force-fitting manner.

In this case, the flow path portions 127 and 128 may extend from the seating portion 125 to the coupling portion 124. These passage portions 127 and 128 are passages for flowing the liquid second drug 116. That is, the flow path portions 127 and 128 may be formed from the bottom surface of the seating portion 125 to the coupling portion 124.

In addition, the flow path portions 127 and 128 may be formed in various shapes inside the body 120. 3, the flow path portions 127 and 128 are illustrated and described as being vertically formed, but the present invention is not limited thereto. For example, the flow path portions 127 and 128 may be formed in a zigzag shape, a straight line, or a curved shape in the horizontal direction inside the main body 120.

On the other hand, when the withdrawal portion 114 of the liquid supply unit 110 is formed to extend to the extension portion 122, the flow path portion 128 may function as a guide. That is, a part of the withdrawal part 114 may be inserted into the flow path part 128.

In this case, a stepped portion may be provided at a boundary between the flow path part 127 and the flow path part 128. That is, the diameter of the flow path part 127 may be smaller than the diameter of the flow path part 128. Accordingly, the end of the lead portion 114 may be supported on the stepped portion.

5 is a cross-sectional view of an example of the microstructure module of FIG. 1.

The microstructure module 130 may include a support plate 131, a microprotrusion 132, and a microstructure 133. Here, the microstructure module 130 may be integrally formed with the microstructure 133. For example, the microstructure module 130 may be formed for a single use.

The support plate 131 may be formed in a plate shape corresponding to the support part 123 of the main body 120. The support plate 131 may have a through hole 134 formed in the center thereof. However, the present invention is not limited thereto, and the through hole 134 may be formed at a different position on the support plate 131. Here, the through hole 134 is for coupling to the coupling portion 124 of the body 120 and may have a shape corresponding to the coupling portion 124. For example, the through hole 134 may have a circular shape.

The fine protrusions 132 may be formed to protrude from the lower side of the support plate 131 at regular intervals. Here, between the microprotrusions 132 and the microprotrusions 132 may function as the first flow path 135 through which the liquid second drug 116 flows. That is, when the microstructure 133 is inserted into the skin, the microprotrusions 132 may form the first flow path 135 between the skin and the support plate 131.

Here, the liquid second drug 116 flowing from the main body 120 flows out through the through hole 134 and flows through the first flow path 135 formed by the microprotrusions 132, thereby affecting the skin. Can be applied.

The microstructure 133 may be formed on the microprotrusions 132. At this time, the microstructure 133 may be formed by spotting after applying the viscous composition to the microprotrusions 132. Here, the viscous composition may be formed by a biocompatible or biodegradable material as described above, or a drug that can be injected into the body, and a combination thereof.

In addition, the microstructure 133 may include a first drug. In this case, the first drug may be integrally formed with the microstructure 133.

In addition, the microstructure 133 may have a circular horizontal cross section. Here, the microstructure 133 may be formed in a circular shape having a predetermined area at a portion joined to the microprotrusions 132. In addition, the microstructure 133 may include a pointed tip portion at a site to be implanted in the skin.

Thereby, the microstructure 133 can be administered to the skin to a certain depth as soon as the microstructure 133 is implanted into the skin with the first drug mounted thereon.

6 is a cross-sectional view of another example of the microstructure module of FIG. 1.

The microstructure module 130 ′ may be provided with an additional flow path in the support plate 131. That is, the microstructure module 130 ′ may further include a second passage 136 and a third passage 137.

The second flow path 136 may be provided in the support plate 131 so as to be orthogonal to the through hole 134. That is, the second flow path 136 may be horizontally formed on the support plate 131 in the direction in which the fine protrusions 132 are formed.

The third passage 137 may be formed on the support plate 131 so that the first passage 135 and the second passage 136 communicate with each other. That is, the third passage 137 may be vertically formed in the support plate 131 so as to communicate with the space between the fine protrusions 132.

Accordingly, the liquid second drug 116 flowing into the through hole 134 may flow more smoothly within the range of the support plate 131. Therefore, the liquid second drug 116 may be applied more evenly to the skin.

7 is a cross-sectional view showing a state in which a microstructure is inserted into the skin by a stamp-type microstructure applicator according to an embodiment of the present invention, and FIG. 8 is a diagram illustrating a state in which a second drug is applied to the skin after FIG. 7 It is a cross-sectional view.

Referring to FIG. 7, when the user presses the skin 10 while holding the handle 121 of the stamp-type microstructure applicator 100, the microstructure 133 is formed by the microprotrusion 132. ) Is inserted within.

At this time, between the support plate 131 and the skin 10, a first flow path 135 between the microprotrusions 132 may be formed.

Referring to FIG. 8, when the user presses the receiving part 112 of the liquid supplying part 110, the liquid second drug 116 passes through the withdrawal part 114 and the flow path part 127, and finally through the through hole ( It can be applied to the skin 10 through 134.

At this time, the liquid second drug 116 may flow through the first flow path 135 between the microprotrusions 132 to diffuse throughout the area of the skin 10 into which the microstructure 133 is inserted. .

Here, the liquid second drug 116 is applied on the skin 10 after the microstructure 133 is implanted on the skin 10 to penetrate, dissolve, diffuse into the skin, and penetrate the microstructure 133 into the skin. At least one of the absorption of can be promoted.

In this case, the liquid second drug 116 may be supplied in full amount at one time or divided and supplied several times. For example, when the liquid second drug 116 is dividedly supplied, it may be repeatedly supplied at predetermined time intervals. That is, by using the dropper method, the receiving unit 112 may supply the liquid second drug 116 at a constant parallax interval.

With such a configuration, the stamp-type microstructure applicator according to the present invention can improve the efficacy of drug delivery and reduce user pain because the microstructure can promote penetration, dissolution, diffusion, and absorption of the microstructure. Therefore, user convenience can be improved.

Although an embodiment of the present invention has been described above, the spirit of the present invention is not limited to the embodiment presented in the present specification, and those skilled in the art who understand the spirit of the present invention can add components within the scope of the same idea. Other embodiments may be easily proposed by changes, deletions, additions, etc., but it will also be said to fall within the scope of the present invention.

100: stamp-type microstructure applicator
110: liquid supply unit 112: receiving unit
114: withdrawal unit 116: second drug
120: main body 121: handle
122: extension part 123: support part
124: coupling portion 125: seating portion
126: protrusion 127, 128: euro part
130: microstructure module 131: support plate
132: microprotrusions 133: microstructure
134: through hole 135: first flow path
136: 2nd euro 137: 3rd euro

Claims (16)

A microstructure module in which a microstructure including a first drug is provided;
A main body coupled to the lower side of the microstructure module to insert the microstructure into the skin by an external force by a user; And
Includes; a liquid supply unit provided on the upper side of the main body and supplying a liquid second drug to the microstructure module side,
In the main body, a flow path part for guiding the second drug supplied from the liquid supply part to the microstructure module is formed,
The liquid second drug is applied on the skin after the microstructure is implanted into the skin to promote at least one of skin penetration, dissolution, diffusion in the skin, and absorption into the skin of the microstructure,
The microstructure module includes a plate-shaped support plate having an upper surface facing the lower portion of the body and having a through hole through which the second drug from the flow path part passes,
A plurality of fine protrusions protrude to the lower side of the plate-shaped support plate,
Each of the microstructures is formed on the plurality of microprotrusions,
In a state in which the microstructure is inserted into the skin, a first flow path is formed between the skin and the support plate by the plurality of microprotrusions,
A stamp-type microstructure applicator that flows so that the liquid second drug that flows out through the through hole passes through the first flow channel, passes through the lower surface of the plate-shaped support plate, and diffuses throughout the area of the skin into which the microstructure is inserted. The method of claim 1,
The plate-shaped support plate is a stamp-type microstructure applicator in which the through hole coupled to the body is provided in the center. delete The method of claim 2,
The support plate is provided with a second passage orthogonal to the through hole therein, and the second passage is a stamp-type microstructure applicator that communicates with between the fine projections. The method of claim 1,
The main body,
A handle for the user to grab;
A seating part provided inside the handle part to which the liquid supply part is mounted;
A plate-shaped support portion protruding downward from the coupling portion to which the microstructure module is coupled;
An extension part extending the support part and the handle part; And
A stamp-type microstructure applicator including a flow path portion formed from the seating portion to the coupling portion and through which the liquid second drug flows. The method of claim 5,
The flow path part is a stamp-type microstructure applicator formed in a vertical, horizontal zigzag, straight or curved shape inside the body. The method of claim 5,
The seating portion is a stamp-type microstructure applicator having a shape corresponding to the shape of the liquid supply portion. The method of claim 5,
The outer diameter of the coupling portion is substantially the same as the inner diameter of the penetrating portion of the microstructure module stamp-type microstructure applicator. The method of claim 1,
The micro-structure module is a stamp-type micro-structure applicator that is coupled to the body by a force-fitting method. The method of claim 1,
The liquid supply unit,
An accommodating part for accommodating the liquid second drug; And
Stamp-type microstructure applicator comprising a withdrawal portion for flowing the liquid second drug through the body. The method of claim 10,
The accommodating part is a stamp-type microstructure applicator for flowing the liquid second drug to the withdrawal part in a dropper manner. The method of claim 10,
The liquid second drug is a stamp-type microstructure applicator that is repeatedly supplied at regular time intervals. The method of claim 10,
The liquid second drug is a stamp-type microstructure applicator comprising at least one of minoxidil, triamcinolone, and finasteride. The method of claim 10,
A stamp-type microstructure applicator provided with at least a portion of the receiving portion protruding outward of the main body. The method of claim 1,
The liquid supply unit is a stamp-type microstructure applicator provided integrally with the body. The method of claim 1,
The liquid supply part is a stamp-type microstructure applicator provided detachably to the body.

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