CN106345051A - Miniature injection needle and integrated device thereof - Google Patents
Miniature injection needle and integrated device thereof Download PDFInfo
- Publication number
- CN106345051A CN106345051A CN201611056980.2A CN201611056980A CN106345051A CN 106345051 A CN106345051 A CN 106345051A CN 201611056980 A CN201611056980 A CN 201611056980A CN 106345051 A CN106345051 A CN 106345051A
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- Prior art keywords
- needle
- medicine
- microneedle
- drug
- skin
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- Pending
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0008—Scalp
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
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- A61M2205/36—General characteristics of the apparatus related to heating or cooling
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
- A61N2005/066—Radiation therapy using light characterised by the wavelength of light used infrared far infrared
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to a miniature injection needle and an integrated device thereof. The miniature needle comprises a needle and a body, wherein the needle comprises a slant part with the outer slant wall, a perfectly straight part with the outer perfectly-straight wall and a groove with the certain depth along the outer slant wall or the outer perfectly-straight wall; the body is coupled to the needle to move or support the needle, the body comprises a cylindrical part and a conical part the body connected to the needle part with the reduced diameter, and a plurality of V-shaped grooves are formed in the surface of the cylindrical part of the body in an etched mode in the axial direction of the body, The invention also relates to a miniature needle head and miniature needle device which are integrated with the miniature needle. The miniature needle and integrated device thereof have the advantages shown in the specification.
Description
Technical Field
The present invention relates to a micro-injection needle and an integrated device of micro-injection needles, and more particularly, to a micro-injection needle having improved drug delivery efficiency and fracture resistance, an integrated device of micro-injection needles for injecting a vaccine for active immunization or a skin care solution for skin care through the skin into the human body more efficiently and maximizing the bioactive effect of infrared rays.
Background
Drugs or medicaments for active immunization such as a care solution or a vaccine (hereinafter may be referred to as a drug) are delivered into the human body by oral administration or injection. However, when a drug is delivered orally, the action of digestive enzymes within the digestive tract may prevent the drug from being absorbed directly into the bloodstream, or may modify the drug to destroy its desired effect. When drugs are delivered by injection, they are absorbed directly into the bloodstream through the skin or veins. Thus, unlike oral administration, the drug is prevented from being modified by digestive enzymes in the digestive tract. However, the needle pierces the dermis of the skin during injection, which can cause pain or infection.
To address these limitations of injection and oral administration, transdermal drug delivery methods for delivering drugs through the skin into local tissues or the entire circulatory system are actively studied. Such a transdermal delivery method may be used with, for example, a microneedle device comprising a microneedle having a plurality of microneedles. The microneedles of the microneedle device are capable of injecting a drug through the skin without pain and physically piercing the epidermis including the stratum corneum of the skin to increase the diffusion rate of the drug from the drug supply site to the dermis. Such microneedles are also commonly referred to as micro-injection needles. When a typical moldless molded microneedle is used to inject the drug, the drug is delivered to the skin along the smooth outer wall of the moldless molded microneedle. However, at this time, a large amount of the drug is blocked by the skin, and a very small amount of the drug is injected into the skin. In addition, when drugs are injected into the skin using hollow type needles having a hollow portion in the center thereof, these hollow type needles are easily broken, and the air of the hollow portion can enter the skin before injection. In addition, typical microneedle devices do not include means for relaxing skin having pores that shrink at low temperatures, or hardened cellular tissue. Therefore, when a drug is injected into the epidermis including the stratum corneum of the skin through the micro needles at low temperature or in winter, the absorption efficiency of the drug through the epidermis, or the delivery efficiency of the drug into the dermis is all decreased. As a result, the injection efficiency of the drug is reduced. In addition, typical microneedle devices do not have a means of preventing leakage of the drug to be supplied from the microneedles through the drug supply site before or after the injection of the drug from the microneedles. Therefore, when the microneedle device is moved to use or store the microneedle device before or after injecting the drug, or when the microneedle head is shaken, the drug may leak through the microneedle. In addition, the performance of typical microneedle devices deteriorates significantly when skin pores shrink at low temperatures, or cellular tissues harden. That is, even if the micro needles pierce the epidermis including the stratum corneum of the skin at a low temperature or in winter, the absorption efficiency of the drug through the epidermis, or the transmission efficiency of the drug into the dermis may be decreased, thereby decreasing the natural healing efficiency of the dermal cells. Furthermore, because these micro-injection needles are extremely delicate, they must closely fit the corresponding components of the device in which they are integrated, while avoiding bending and breaking. However, it is preferable that the device for forming these micro-needles is made of synthetic resin. However, it has been found that certain drugs have problems with poor flow of the drug solution when using such devices incorporating a microneedle.
Accordingly, there remains a need in the art for a device for delivering a drug to the skin that overcomes one or more of the problems described above.
Disclosure of Invention
It is an object of the present application to provide a micro-injection needle and an integrated device thereof, and it is expected that the micro-injection needle and the integrated device thereof can overcome one or more problems of the related art. It has been surprisingly found that this object in one or more aspects can be achieved by the inventive design. The present invention has been completed based on this finding.
An embodiment of the present invention is to provide a microneedle for injecting a drug into the skin through a groove provided in an outer wall of the microneedle, thereby improving drug delivery efficiency of the microneedle and preventing breakage of the microneedle.
An embodiment of the present invention is to provide a micro needle device which heats the skin to expand skin pores when a drug is injected, or stimulates the skin by means of infrared rays and/or far infrared rays, thereby improving drug delivery efficiency.
An embodiment of the present invention provides a microneedle device that emits infrared rays to the inside of the skin and the epidermis, thereby maximizing the effect of the infrared rays.
In particular, a first aspect of the invention provides a microneedle, comprising:
a needle including an inclined portion having an inclined outer wall, a straight portion having a straight outer wall, and a groove having a depth along the inclined outer wall or the straight outer wall; and
a body coupled to the needle to move or support the needle.
According to the above design, the micro needle has improved drug delivery efficiency and is resistant to breakage.
A microneedle according to a first aspect of the present invention, wherein the groove has a straight linear shape extending along the needle and is recessed to a certain depth toward the center of the needle.
The microneedle according to the first aspect of the present invention, wherein the grooves are provided in three or more along the outer wall of the needle, or in four at constant intervals along the outer wall at the upper, lower, left and right sides.
A microneedle according to a first aspect of the present invention, wherein the groove extends from one end of the inclined portion to a part or end of the straight portion and has a plurality of branch shapes.
The microneedle according to the first aspect of the present invention, wherein the groove has a cross (+) shape or a flat (-) shape.
A microneedle according to the first aspect of the invention, in which the recess has a thread shape extending clockwise or counterclockwise along the outer wall of the needle.
A microneedle according to a first aspect of the present invention, in which the body has a cylindrical shape and a tapered shape that decreases in diameter at a portion connected to the needle.
According to the microneedle of the first aspect of the present invention, a plurality of V-grooves are etched in the axial direction of the cylindrical surface of the body, and the depth of the V-grooves is 1/50 to 1/15 (for example, 1/40 to 1/15) of the radius of the body.
A microneedle according to a first aspect of the present invention, in which the plurality of V-shaped grooves cover 1/8-1/5 regions (e.g. 1/7-1/5 regions) of the radial surface of the body in a radial cross-section of the cylindrical-shaped subsection of the body.
A microneedle according to a first aspect of the present invention, wherein the plurality of V-grooves extend from the tapered shape of the body to the other end of the body in the axial direction of the body.
Further, the present invention provides in a second aspect a microneedle device comprising:
a medicine storage portion for storing a medicine;
a micro needle including a drug channel connected to the drug storage part, and a plurality of micro needles having a front end portion protruding from the micro needle, wherein the micro needles pierce the dermis of the skin to transfer the drug from the drug channel to the dermis of the skin when the micro needles are pressed toward the skin; and
a heating part for heating the skin through the micro needle.
The microneedle device according to a second aspect of the present invention, wherein the drug storage part is formed by connecting a drug storage chamber and a drug supply tube to each other.
A microneedle device according to a second aspect of the present invention, wherein the drug storage chamber comprises a drug reservoir, a drug chamber, a drug selector, and at least two drug units longitudinally spaced apart to receive a plurality of drugs.
A microneedle device according to a second aspect of the present invention, wherein the drug selector comprises:
a hollow housing permitting rotation of the drug storage portion therein;
a shutter disposed at a lower end of the housing and including a selection hole corresponding to an outlet of one of the plurality of medicine units;
a rotor provided at an upper end of the medicine storage part; and
an upper cover closing an upper portion of the medicine storage part, supporting the rotor and allowing the rotor to rotate,
wherein the rotor rotates to rotate the drug storage portion within the housing.
A microneedle device according to a second aspect of the present invention, wherein the drug selector comprises:
a hollow housing permitting rotation of the drug storage portion therein;
a plurality of medicine units including an elastic member and an opening/closing ball inside the medicine storage part;
a shutter disposed at a lower end of the housing and including a selection hole corresponding to an outlet of one of the medicine units;
a rotor provided at an upper end of the medicine storage part; and
an upper cover closing an upper portion of the medicine storage part, supporting the rotor and allowing rotation of the rotor,
wherein the rotor rotates to rotate the drug storage portion within the housing.
A microneedle device according to a second aspect of the present invention, wherein the drug selector comprises:
a rotation shutter provided at a lower end portion of the medicine storage portion and capable of blocking the lower end portions of the medicine units in a rotatable manner, the rotation shutter including a selection hole corresponding to a lower end portion of one of the plurality of medicine units;
a rotor provided at an upper end of the medicine storage portion and rotatably blocking an upper end of the medicine unit; and
a rotation rod passing through the medicine storage part and connecting the rotation barrier to the rotor,
wherein, when the rotor rotates, the rotation baffle rotates with the dwang is integrative.
A microneedle device according to a second aspect of the present invention, wherein the microneedle head comprises:
a stationary body forming the drug channel therein;
a needle fixing plate fixing the micro needle; and
a needle cover forming a medicine dispensing space together with the needle fixing plate to communicate with the medicine passage and including a needle hole through which the micro needle is exposed to the outside;
wherein each of the needle holes has an inner diameter slightly larger than an outer diameter of the microneedle to discharge the drug from the drug dispensing space along the microneedle.
A microneedle device according to a second aspect of the present invention, wherein the microneedle further comprises a drug blocking portion comprising:
a blocking rod disposed inside the drug channel, the blocking rod opening the drug channel when the micro needle contacts the skin and closing the drug channel when the micro needle is spaced apart from the skin, wherein the blocking rod is movable between a first position for opening the drug channel and a second position for closing the drug channel; and
a spring elastically supporting the blocking lever to maintain the blocking lever at the second position.
A microneedle device according to a second aspect of the present invention, wherein the blocking lever comprises:
a pressing end portion protruding to the outside more than a front end portion of the microneedle when the pressing end portion is located at the second position;
a spring seat supporting a spring between the medication passage and the spring seat; and
a blocking end that blocks the medication channel in the second position.
The microneedle device according to the second aspect of the present invention, wherein the fixing body of the microneedle head, the needle fixing plate and the needle cover are made of synthetic resin (e.g., polymethylmethacrylate or polycarbonate, etc.) or organic glass.
A microneedle device according to a second aspect of the present invention, in which the microneedles are as described in any one of the embodiments of the first aspect of the present invention.
A microneedle device according to a second aspect of the present invention, wherein the plurality of V-shaped grooves on the microneedle extend in the axial direction of the body from the tapered shape of the body at least into the drug dispensing space of the microneedle head.
The microneedle device according to a second aspect of the present invention, wherein the heating portion is provided between the drug storage portion and the microneedle head at one of a position spaced apart from the microneedle head by a distance and a position contacting the microneedle head.
A microneedle device according to a second aspect of the present invention, wherein the heating part includes at least one of a far-infrared ray generator part coupled to the heater and generating far-infrared rays by means of heat from the heater, and an infrared ray generator part generating infrared rays.
According to a second aspect of the present invention, the microneedle device, wherein the infrared ray generator section includes one of a lamp and a light emitting diode that generates infrared rays.
Further, a third aspect of the present invention provides a micro needle, comprising:
a stationary body forming the drug channel therein;
a needle fixing plate on which a micro needle is fixed; and
a needle cover forming a medicine dispensing space together with the needle fixing plate to communicate with the medicine passage and including a needle hole through which the micro needle is exposed to the outside;
wherein each of the needle holes has an inner diameter slightly larger than an outer diameter of the microneedle to discharge the drug from the drug dispensing space along the microneedle.
The micro needle according to the third aspect of the present invention, further comprising a drug blocking portion, the drug blocking portion comprising:
a blocking rod disposed inside the drug channel, the blocking rod opening the drug channel when the micro needle contacts the skin and closing the drug channel when the micro needle is spaced apart from the skin, wherein the blocking rod is movable between a first position for opening the drug channel and a second position for closing the drug channel; and
a spring elastically supporting the blocking lever to maintain the blocking lever at the second position.
The microneedle according to a third aspect of the present invention, wherein the blocking lever comprises:
a pressing end portion protruding to the outside more than a front end portion of the microneedle when the pressing end portion is located at the second position;
a spring seat supporting a spring between the medication passage and the spring seat; and
a blocking end that blocks the medication channel in the second position.
The micro-needle according to the third aspect of the present invention, wherein the fixing body, the needle fixing plate and the needle cover are made of synthetic resin (e.g., polymethylmethacrylate or polycarbonate, etc.) or organic glass.
A microneedle according to a third aspect of the invention, in which the microneedle is as described in any embodiment of the first aspect of the invention.
The microneedle according to the third aspect of the present invention, wherein the plurality of V-grooves on the microneedle extend from the tapered shape of the body in the axial direction of the body at least into the drug dispensing space of the microneedle.
Further, a fourth aspect of the present invention relates to a microneedle injector comprising:
a microneedle according to any of the embodiments of the third aspect of the present invention;
a cap for covering one end of the microneedle, at which the microneedle is exposed, so that the microneedle injector protects the microneedle when not in use;
and the opening end of the liquid medicine bottle is detachably and hermetically connected with one end of the fixing body of the micro needle head.
The microneedle injector according to the fourth aspect of the present invention, wherein the liquid medicine bottle and the micro needle are hermetically connected by a screw.
According to the microneedle injector in the fourth aspect of the present invention, the material of the liquid medicine bottle is selected from glass, plastic, plexiglass and metal.
Any technical feature possessed by any one aspect of the invention or any embodiment of that aspect is equally applicable to any other embodiment or any embodiment of any other aspect, so long as they are not mutually inconsistent, although appropriate modifications to the respective features may be made as necessary when applicable to each other. Various aspects and features of the disclosure are described further below.
All documents cited herein are incorporated by reference in their entirety and to the extent such documents do not conform to the meaning of the present invention, the present invention shall control. Further, the various terms and phrases used herein have the ordinary meaning as is known to those skilled in the art, and even though such terms and phrases are intended to be described or explained in greater detail herein, reference is made to the term and phrase as being inconsistent with the known meaning and meaning as is accorded to such meaning throughout this disclosure.
The micro-needle according to the present invention, which has a cross (+) shape, can deliver a drug into the skin. In addition, since the groove is provided only in the needle sidewall, the strength of the needle can be secured, thereby preventing the needle from being broken in the skin when injecting the medicine.
The micro needle according to the present invention includes a groove having a cross (+) shape, so that a certain amount of medicine is stored in the groove and injected into the skin. Therefore, the medicine stored in the groove can be effectively injected into the skin. In addition, since the groove is short at the straight portion of the needle, the strength of the needle can be secured, thereby preventing the needle from breaking in the skin when injecting medicine.
According to the micro needle of the present invention, since the groove extending along the central portion of the needle has a large volume, a relatively large amount of drug can be efficiently delivered into the skin.
The micro needle according to the present invention includes a groove having a flat (-) shape, so that a certain amount of medicine is stored in the groove and injected into the skin. Therefore, the medicine stored in the groove can be effectively injected into the skin. In addition, since the groove is short in the straight portion of the needle, the strength of the needle is relatively high, thereby fundamentally preventing the needle from breaking in the skin when injecting the medicine.
According to the micro needle of the present invention, since the two micro needles face each other, a larger amount of the drug can be stored. In addition, since the needle composed of two small needles includes the groove having a flat (-) shape, the strength of the needle can be further increased, thereby preventing the needle from being broken in the skin when injecting the medicine.
A microneedle according to the present invention includes a groove having a thread shape to store a certain amount of medicine. In addition, when the needle is inserted into the skin, the medicine from the body may be rotated in a circumferential direction along the groove having a screw shape and slowly injected into the skin.
According to the present invention, a drug is injected into the skin through the grooves provided in the outer wall of the microneedles, thereby improving the drug delivery efficiency of the microneedles and preventing the microneedles from being broken.
In addition, the microneedle device integrated using the microneedles of the embodiments includes: a heater for heating the skin to dilate skin pores when the medicine is injected; and/or an infrared ray generator section and/or a far infrared ray generator section for stimulating the skin by means of infrared rays and/or far infrared rays. Therefore, when injecting the medicine, the micro-needle device stimulates skin cells by means of heat from the heater and infrared rays and/or far infrared rays from the infrared ray generator part and/or the far infrared ray generator part, thereby activating the cells and obtaining improved blood circulation in the skin, thermotherapy effect, suppurating effect, drying effect, evaporation effect, and resonance effect. Accordingly, the drug passes through the epidermis of the skin along the micro needles and passes through the expanded pores and the activated cells to reach the dermis, thereby improving the drug delivery efficiency.
According to some embodiments of the present invention, the drug storage portion is formed by connecting a drug storage chamber and a drug supply tube to each other, the drug storage chamber including a drug reservoir, a drug chamber, a drug selector, and at least two drug units longitudinally isolated to receive a plurality of drugs. Therefore, the medicine selector can simply and selectively supply a plurality of medicines from the medicine storage portion to the skin.
According to some embodiments of the invention, the drug blocking portion opens the drug channel when the microneedle contacts the skin, and closes the drug channel when the microneedle is spaced apart from the skin. Therefore, when the micro needle is spaced apart from the skin before or after injecting the drug, the drug can be automatically prevented from leaking through the micro needle, so that the user can freely move the micro needle to a target location without worrying about the drug leaking from the micro needle.
According to some embodiments of the present invention, since the microneedle device according to another embodiment emits infrared rays from the outside of the skin and supplies the infrared rays to the inside of the skin, it is possible to very effectively combine the skin improvement effect of the microneedles and the bioactivity effect of the infrared rays. In particular, when the microneedle device is used for a human head, the scalp can be stimulated by the microneedles and infrared rays, and the hair follicles of the scalp can be stimulated and heated to improve the quality of hair and prevent hair loss.
Drawings
Figures 1a to 1e are views illustrating a microneedle according to one embodiment of the present application.
Figures 2a to 2e are views illustrating microneedles according to one embodiment of the present application.
Figures 3a to 3d are views illustrating microneedles according to one embodiment of the present application.
Figures 4a to 4d are views illustrating microneedles according to one embodiment of the present application.
Figures 5a to 5d are views illustrating microneedles according to one embodiment of the present application.
Figures 6a to 6d are views illustrating microneedles according to one embodiment of the present application.
Figure 7 is a perspective view illustrating a microneedle device according to one embodiment of the present application.
Figure 8 is an exploded perspective view illustrating a microneedle device according to one embodiment of the present application.
Figure 9 is a cross-sectional view illustrating a drug storage chamber of a drug storage portion of a microneedle device according to one embodiment of the present application.
Fig. 10 is a cross-sectional view taken along line 2-2 of fig. 9.
Fig. 11 is a cross-sectional view taken along line 3-3 of fig. 9.
Figure 12 is a cross-section of a drug storage chamber illustrating a drug storage portion of a microneedle device according to one embodiment of the present application.
Fig. 13 is a cross-sectional view taken along line 4-4 of fig. 12.
Figures 14 and 15 are cross-sectional views illustrating the operation of the microneedle device of figures 7 and 8.
Fig. 16 is an embodiment of a microneedle injector of the present invention.
Detailed Description
The present invention will be further described by the following examples, however, the scope of the present invention is not limited to the following examples. It will be understood by those skilled in the art that various changes and modifications may be made to the invention without departing from the spirit and scope of the invention. The present invention has been described generally and/or specifically with respect to materials used in testing and testing methods. Although many materials and methods of operation are known in the art for the purpose of carrying out the invention, the invention is nevertheless described herein in as detail as possible.
Various embodiments of the present invention are described in detail below with reference to the accompanying drawings.
The microneedles of the present application are first described with reference to figures 1 to 6. Respective sub-figures (a) to (d) of fig. 1 to 6 are views illustrating a microneedle a according to an embodiment, in which: the figures corresponding to the letter a are perspective views; the figure corresponding to the letter b is a front view; the figure corresponding to letter c is a side view; and the drawing corresponding to the letter d is a top view.
Referring to figure 1, there is a microneedle a according to a first embodiment of the present invention, comprising a needle 1 and a body 2.
The needle 1 pierces the skin to inject the medicine. The body 2 is coupled to the needle 1 to move or support the needle 1. The medicament is delivered from the body 2 to the needle 1. The body 2 has a substantially cylindrical shape and a tapered shape of which the diameter is reduced at a portion connected to the needle 1, the needle 1 having a diameter smaller than that of the body 2.
The needle 1 comprises: a straight portion 20 having an end connected to the body 2 and including a straight outer wall; and an inclined portion 10 extending outward from the other end portion of the straight portion 20 and including an inclined outer wall having a sharp end portion with a reduced diameter.
Both the inclined portion 10 and the straight portion 20 may pierce the skin, or only the inclined portion 10 may pierce the skin according to the user's needs.
A groove 31, which has a linear shape extending along the needle 1 and is recessed toward the center of the needle 1 by a certain depth, is provided in the outer wall of the inclined portion 10 and the outer wall of the straight portion 20. The grooves 31 extend from one end of the straight portion 20 through the other end thereof to the inclined portion 10, and may be provided to be arranged in four at constant intervals on the upper, lower, left, and right sides of the outer wall of the needle 1, as shown in fig. 1 d. Alternatively, the grooves 31 may be provided in three or more.
When the grooves 31 are provided in four, the needle 1 has a cross (+) shape as shown in fig. 1 d. Thus, the drug can be efficiently delivered into the skin along the groove 31 provided in the sidewall of the needle 1. In addition, since the groove 31 is provided only in the sidewall of the needle 1, the strength of the needle 1 can be secured, thereby preventing the needle 1 from being broken in the skin when injecting medicine.
Figures 2a to 2d are views illustrating microneedles according to a second embodiment. Like reference numerals denote like elements in the first and second embodiments, and thus the description thereof will be omitted in the current embodiment.
Referring to fig. 2a to 2d, the cross-shaped recess 32 is recessed toward the body 2 by a certain depth at the central portion of the inclined portion 10 of the needle 1. The groove 32 may extend from one end of the inclined portion 10 to a portion of the straight portion 20 as shown in fig. 2b and 2c, and have a cross (+) shape having four branch portions branching toward the upper, lower, left and right sides of the needle 1 as shown in fig. 2 d. Although not shown, the groove 32 may have a shape such as an asterisk with six branches or a shape with three or more branches, as viewed in a plan view.
Since the groove 32 has a cross (+) shape as shown in fig. 2a to 2d, a certain amount of medicine is stored inside the groove 32. In this state, when the needle 1 is inserted into the skin, the medicine stored in the groove 32 is effectively injected into the skin. In addition, since the groove 32 has a short portion in the straight portion 20 of the needle 1, the strength of the needle 1 can be secured, thereby preventing the needle 1 from being broken into the skin when injecting the medicine.
Figures 3a to 3d are views illustrating a microneedle according to a third embodiment, which is a modification of the second embodiment of figures 2a to 2 d. Referring to fig. 3d, the groove 33 is in the shape of a cross (+) having four branches branching toward the upper side, the lower side, the left side and the right side, or in the shape provided with at least five branches, like the groove 32 of fig. 2a to 2 d.
However, as shown in fig. 3a to 3c, the groove 33 extends not only completely through the inclined portion 10, but also completely through the straight portion 20. Thus, the needle 1 is divided into four small-pointed needles, so that a larger amount of the medicine can be stored in the groove 33 provided between these small-pointed needles. Although the strength of the needle 1 of the third embodiment is slightly lower than that of the needle 1 of the second embodiment, the volume of the groove 33 extending along the central portion of the needle 1 is increased so that a larger amount of medicine can be efficiently injected into the skin.
Figures 4a to 4d are views illustrating microneedles according to a fourth embodiment. Referring to fig. 4a to 4d, the flat shape (-) groove 34 is recessed toward the body 2 by a certain depth at the central portion of the inclined portion 10 of the needle 1. The groove 34 may extend from one end of the inclined portion 10 to a portion of the straight portion 20 as shown in fig. 4c, and have a flat (-) shape with two branches branching toward the left and right sides (or upper and lower sides) of the needle 1 as shown in fig. 4 d.
Since the groove 34 has a flat (-) shape as shown in fig. 4a to 4d, a certain amount of the medicine is stored in the groove 34. In this state, when the needle 1 is inserted into the skin, the medicine stored in the groove 34 is effectively injected into the skin. In addition, since the groove 34 has a shorter portion in the straight portion 20 of the needle 1 and the branch portion of the groove 34 is less than that of the groove 33 of the second embodiment, the strength of the needle 1 can be increased, thereby preventing the needle 1 from being broken in the skin to a greater extent when injecting the medicine.
Fig. 5a to 5d are views illustrating a microneedle according to a fifth embodiment, which is a modification of the fourth embodiment of fig. 4a to 4 d. Referring to fig. 5d, the groove 35 is the same as the groove 34 of fig. 4a to 4d, and has a flat (-) shape with two branches branching to the left and right (or upper and lower sides).
However, as shown in fig. 5a and 5c, the groove 35 extends not only completely through the inclined portion 10, but also completely through the straight portion 20. Therefore, the needle 1 is divided into two facing small-pointed needles, so that a larger amount of the medicine than that stored in the groove 34 of the fourth embodiment can be stored in the groove 35 provided between the two small-pointed needles. Although the strength of the needle 1 of the fifth embodiment is slightly lower than that of the needle 1 of the fourth embodiment, the volume of the groove 35 extending along the central portion of the needle 1 is increased so that a larger amount of medicine can be efficiently injected into the skin. In addition, since the groove 35 has a flat (-) shape, the strength of the needle 1 can be further increased unlike the groove 33 of the third embodiment, thereby preventing the needle 1 from being broken when injecting the medicine.
Figures 6a to 6d are views illustrating a microneedle according to a sixth embodiment. Referring to fig. 6, a groove 36 having a screw shape with a certain depth extends along the outer wall of the needle 1. The groove 36 is provided on the entire area of the straight portion 20 of the needle 1 and a part of the inclined portion 10. The groove 36 may be rotated clockwise as shown in fig. 6d, or counterclockwise, and has a curved inner surface, and the width of the groove 36 may be varied according to design.
Thus, according to the sixth embodiment, the recess 36 may store a certain amount of drug. In addition, when the needle 1 is inserted into the skin, the medicine from the body 2 may be rotated in the circumferential direction along the groove 36 and slowly injected into the skin.
According to the above various embodiments, the drug is injected into the skin through the grooves provided in the outer wall of the microneedles, thereby improving the drug delivery efficiency of the microneedles and preventing the microneedles from being broken.
Although the drug is delivered into the skin through the microneedles in the embodiments, the cosmetic agent may also be delivered through the microneedles.
Hereinafter, a microneedle device according to an embodiment will be described in detail with reference to the accompanying drawings, in particular, fig. 7 to 13.
Figures 7 and 8 are perspective views illustrating a microneedle device B according to one embodiment.
The microneedle device B is a percutaneous device for more efficiently injecting a vaccine for active immunization or a skin elasticity care solution for skin care into the body through the skin. The micro-needle device B includes a power supply part 40, a drug storage part 50, a micro-needle 60, and a heating part 70.
The power supply portion 40 includes a cylindrical body 41 having a cylindrical shape. The cylindrical body 41 has a battery space for accommodating a dry battery or a battery pack. For example, two 1.5V dry cell batteries may be arranged in series within the cell space. A switch 42 for selectively supplying electric power is provided on the outer circumferential surface of the cylindrical body 41, and a cover 43 closes the bottom of the cylindrical body 41. The cylindrical body 41 functions not only as a power supply portion 40 for accommodating a dry cell or battery pack but also as a body for holding the microneedle device B by a user when injecting a medicine.
The medicine storage portion 50 is coupled to the cylindrical body 41 of the power supply portion 40, and includes a medicine storage chamber 51 inside the medicine storage portion 50 to store medicine. A medicine supply tube 52 is provided at the outlet of the medicine storage chamber 51. The medicine supply tube 52 is extended and airtightly connected to an inlet 62 of a fixing body 61 of a micro needle 60 described later.
The heating part 70 is disposed between the medicine storing part 50 and the micro needle 60. When the medicine is injected into the skin, the heating part 70 heats the skin to expand pores and stimulate the skin to activate skin cells. To achieve this, the heating part 70 includes an outer cylinder 71, an inner cylinder 72, and a heater 73 provided between the outer cylinder 71 and the inner cylinder 72.
A right end portion of the outer cylinder 71 is coupled to a left end portion of the medicine storage portion 50 by means of a member such as a screw. The outer tub 71 includes a heat insulator for heat insulation. The inner cartridge 72 receives the drug supply tube 52 and passes the drug supply tube 52 therethrough. Similar to the outer cartridge 71, the inner cartridge 72 includes an insulator for protecting the medicine supply tube 52 from radiant heat of the heater 73. A support 74 mounted on the outside of the inner cylinder 72 fixes the heater 73 at a position spaced apart from the micro-needle 60. The heater 73 heats the microneedle 60 to transmit heat to the skin. For example, the heater 73 includes a parallel connection wire 75, such as a nichrome wire having a width of about 3mm, to continuously emit heat in a range of about 40 to 50 ℃.
As described above, the heater 73 is fixed at a position spaced apart from the micro-needle 60 and indirectly heats the micro-needle 60. Alternatively, the heater 73 may directly contact the micro-needle 60 and/or the micro-needle a of the micro-needle 60 to directly heat the micro-needle 60 and/or the micro-needle a, thereby transferring heat to the skin.
Far infrared rays and/or infrared rays may be emitted to the skin to stimulate the skin, so that the microneedles a of the microneedle 60, described later, can more efficiently deliver the drug to the dermis of the skin. To this end, the heating part 70 may include a far infrared ray generator 76 and/or an infrared ray generator 77.
Although a microneedle a is illustrated in the current embodiment, the present disclosure is not so limited, and thus a typical needle without threads or grooves around its side wall may also be used.
The far infrared ray generator 76 is coupled to the inside of the outer tub 71 to face the heater 73 so that far infrared rays can be generated by means of heat from the heater 73. To this end, the far infrared ray generator 76 includes a cylindrical body 78, the cylindrical body 78 having an outer diameter smaller than an inner diameter of the outer cylinder 71, and being disposed on the outside of the heater 73 in a left portion of the outer cylinder 71. The cylinder 78 may be formed of jewels or ceramics.
Alternatively, the far infrared ray generator 76 may be disposed between the heater 73 and the inner tube 72. In this example, the far infrared ray generator 76 includes a cylindrical body (not shown) having an inner diameter larger than an outer diameter of the inner cylinder 72, and the heater 73 is fixed by a support (not shown) mounted on the outside of the cylindrical body.
The infrared ray generator 77 is disposed between the heater 73 and the medicine storage part 50 to generate infrared rays. The infrared ray generator 77 includes a fixed ring 79 having a circular shape and a plurality of infrared ray LEDs (liquid crystal displays) or lamps 80 generating infrared rays having wavelengths, for example, in the range of about 700nm to 20 μm. The fixing ring 79 includes a circular hole 81 at a central portion thereof, and the inner cylinder 72 is fitted into the circular hole 81. The far infrared rays and infrared rays generated by the far infrared ray generator 76 and the infrared lamp 80, and the heat generated by the heater 73 are reflected to the micro needle 60. To this end, the surface of the fixing ring 79 on which the infrared lamp 80 is mounted may include a reflecting surface. A plurality of infrared lamps 80 are arranged at regular intervals around the circular hole 81 of the fixing ring 79.
The heater 73 and the infrared lamp 80 are electrically connected to the power supply portion 40 through an electric wire (not shown) provided in the medicine storage portion 50.
Thus, the far infrared rays generated by the far infrared ray generator 76 and the infrared rays generated by the infrared ray generator 77 can have the following effects: during injection, skin cells may be stimulated and activated; active oxygen accumulated due to environmental pollution can be removed from the body; the double bond of unsaturated fatty acid can be used for improving cosmetic effect; tissues that are acidified due to inflammation may be alkalized. Thus, improved blood circulation in the skin, thermotherapy effect, suppurating effect, dampness eliminating effect, evaporation effect and resonance effect can be obtained.
Referring to fig. 9 to 11, the medicine storage chamber 51 of the medicine storage part 50 is connected to the medicine supply tube 52, and includes a medicine storage 51a, a medicine chamber 51b, a medicine selector 51c, and at least two medicine units 51d longitudinally partitioned to receive a plurality of medicines. The drug reservoir 51a is provided with a housing 51 e. The medicine reservoir 51a has a hollow cylindrical shape, and is therefore rotatable inside the housing 51 e. The inner spacer 51f of the medicine reservoir 51a divides the medicine reservoir 51a into at least two longitudinal spaces. As shown in fig. 10, the spacer 51f may have a cross shape, and thus the number of the medicine units 51d may be four. However, the number of the medicine units 51d is not limited to four, and thus may be two or more. A plurality of outlets 51h are provided in the lower end portions 51g of the plurality of medicine units 51d, respectively, to discharge the medicine.
The medicine chamber 51b is disposed below the medicine reservoir 51a to receive the medicine discharged from the medicine unit 51d through the outlet 51 h. That is, the medicine chamber 51b is provided between the medicine supply tube 52 and the medicine storage 51a to form a space for temporarily storing the medicine discharged from the medicine unit 51 d. The medicine chamber 51b may have a hollow cylindrical shape having an outer diameter substantially the same as that of a housing 51e described later. The medicine stored in the medicine chamber 51b is discharged to the micro needle 60 through the medicine supply tube 52.
The drug selector 51c is used to select one of the plurality of drug units 51d of the drug storage 51 a. Then, the medicine stored in the selected one of the medicine units is discharged to the micro needle 60 through the medicine chamber 51b and the medicine supply tube 52. The drug selector 51c may be configured in various forms.
For example, the drug selector 51c may be configured to rotate the drug reservoir 51a to select one of the plurality of drug units 51d of the drug reservoir 51 a.
The medicine selector 51c includes a housing 51e that allows the medicine storage 51a to rotate therein, and a shutter 51i provided at a lower end portion of the housing 51 e. The lower end portion of the housing 51e is inserted into the medicine chamber 51 b. A sealing member (not shown) may be provided between the shutter 51i and the lower end 51g of the drug reservoir 51a to allow the drug reservoir 51a to rotate relative to the shutter 51i and prevent the drug stored in the drug unit 51d from leaking and mixing. Referring to fig. 9 and 11, the shutter 51i is provided with a selection hole 51j corresponding to the outlet 51h of one of the plurality of medicine units 51 d. Therefore, when the medicine storage 51a is rotated to match the outlet 51h of one of the plurality of medicine units 51d with the selection hole 51j, the medicine stored in the medicine unit 51d is discharged to the medicine chamber 51b through the selection hole 51 j.
The rotor 51k is provided on an upper end portion of the medicine reservoir 51a for the user to rotate the medicine reservoir 51a, and extends from the cover 43 of the power supply portion 40, not shown. Thus, the user can conveniently rotate the medicine storage 51 a.
An upper cover 51l is provided on the housing 51e to close an upper portion of the medicine reservoir 51 a. The upper cover 51l is provided with a support hole 51m to support a support shaft 51n for rotating the rotor 51 k. Therefore, the support shaft 51n of the rotor 51k can rotate in the support hole 51m of the upper cover 51 l. When the user grips the rotor 51k and rotates the rotor 51k in the arrow direction X shown in fig. 9, the medicine reservoir 51a also rotates in the arrow direction X within the housing 51 e. Therefore, when the rotor 51k rotates to match the outlet 51h of one of the plurality of medicine units 51d with the selection hole 51j of the shutter 51i, the medicine stored in the medicine unit 51d is discharged to the medicine chamber 51b through the selection hole 51 j.
Further, referring to fig. 12 and 13, an elastic member 51o and an opening/closing ball 51p may be provided in each of the plurality of medicine units 51 d. Therefore, the user can select one of the plurality of medicine units 51d by sensing the insertion of the opening/closing ball 51p into the selection hole 51j only by the elasticity of the elastic member 51o provided in the medicine unit 51d without observing the insertion of the opening/closing ball 51p with his/her own eyes.
Thus, when the elastic member 51o and the opening/closing ball 51p are disposed inside the medicine unit 51d, the medicine selector 51c includes a housing 51e and a shutter 51i, the housing 51e allowing the medicine storage 51a to rotate therein, the shutter 51i being disposed at a lower end portion of the housing 51 e. In this example, the lower end of the housing 51e is inserted into the medicine chamber 51b, and the medicine storage 51a is rotatable relative to the shutter 51 i. In addition, the shutter 51i is provided with a selection hole 51j corresponding to the outlet 51h of one of the plurality of medicine units 51 d. Referring to fig. 13, a plurality of projections 51q are provided around the selection hole 51j of the shutter 51i, and the medicine from the medicine unit 51d is discharged from between the plurality of projections 51q to the medicine chamber 51 b.
As described above, when the user grips the rotor 51k and rotates the rotor 51k in the arrow direction X shown in fig. 12, the medicine storage 51a also rotates in the arrow direction X inside the housing 51 e. Therefore, when the rotor 51k is rotated to match the outlet 51h of one of the plurality of medicine units 51d with the selection hole 51j of the shutter 51i, the medicine stored in the medicine unit 51d is discharged to the medicine chamber 51b from between the plurality of projections 51q provided around the selection hole 51 j.
Referring next to the drawings, and in particular to figures 14 and 15, the micro-needle of the present invention will be discussed.
The micro needles 60 allow painless injection of the drug through the skin C and physically penetrate the epidermis including the stratum corneum layer of the skin C to increase the diffusion rate of the drug through the skin C. Referring to fig. 14 and 15, the micro-needle 60 includes a fixing body 61, a medicine blocking part 63, a needle fixing plate 68, and a needle cover 65.
The fixing body 61 is provided with an inlet 62 coupled to the medicine supply tube 52, and a medicine passage 66 is provided within the fixing body 61 to communicate with the medicine supply tube 52. The medication channel 66 has a shape of a pyramid block and includes an upper channel 66a, a lower channel 66b, and a middle channel 66c for connecting the upper channel 66a to the lower channel 66 b. A blocking seat 64a having a frustoconical shape is disposed in a lower portion of the upper channel 66a and is coupled to a blocking end of a blocking rod 64 described later to block the medicine channel 66. A first spring seat 67a is provided in an upper portion of the lower passage 66b to support an upper end portion of a spring 67 described later.
When the micro-needle 60 contacts the skin C, the drug passage 66 is opened as shown in fig. 15, and when the micro-needle 60 is spaced apart from the skin C, the drug passage 66 is closed as shown in fig. 14. To this end, a drug blocking portion 63 is provided inside the drug passage 66.
The medicine blocking portion 63 includes a blocking lever 64, and the blocking lever 64 is movable between a first position (see fig. 15) for opening the medicine passage 66 and a second position (see fig. 14) for closing the medicine passage 66. The blocking lever 64 includes a pressing end portion 64b, a second spring seat 64c, and a blocking end portion 64 d. When the jamming lever 64 is disposed at the second position, the pressing end 64b protrudes from the needle cover 65 more than the front end of the microneedle a protrudes from the needle cover 65. The second spring seat 64c supports a lower end portion of the spring 67 such that the spring 67 is mounted between the first spring seat 63a and the second spring seat 64c, and has a through hole (not shown) in the spring 67 to pass the medicine. The blocking end 64d has a shape corresponding to the blocking seat 64a of the medicine passage 66. Thus, when the blocking lever 64 is disposed in the second position, the blocking end 64d engages the blocking seat 64a to block the medication channel 66.
In order to hold the blocking lever 64 at the second position, a spring 67 is provided between the first spring seat 67a of the upper passage 66a and the second spring seat 64c of the blocking lever 64 to elastically support the blocking lever 64. The spring 67 may comprise a compression spring.
Therefore, when the micro-needle 60 contacts the skin C as shown in fig. 15, the pressing end 64b is moved upward by the skin C against the elastic force of the spring 67 to move the blocking lever 64 to the first position. Thus, the blocking end 64d is spaced from the blocking seat 64a to open the medication passage 66. In contrast, when the micro-needle 60 is spaced apart from the skin C as shown in FIG. 14, the blocking lever 64 is restored to the second position by the elastic force of the spring 67. Thus, the blocking end 64d contacts the blocking seat 64a to close the medicine passage 66.
The needle retainer plate 68 retains the upper ends of the microneedles a in an array. The microneedles a are solid and not hollow, and the lower ends of the microneedles a protrude from the needle cover 65. Thus, when contacting the skin C, the micro-needles a pierce the epidermis of the skin C and the drug supplied from the drug channel 66 is delivered to the dermis of the skin C. For example, the protruding length of the lower end of the microneedle a from the needle cover 65 may be in the range of about 200 to 500 μm. Therefore, when the micro-needle a contacts the skin C, the lower end portion of the micro-needle a pierces the epidermis of the skin C to efficiently deliver the drug without irritating the pain spot of the skin C.
The needle cover 65 and the needle fixing plate 68 are fixed to the fixing body 61 by means of fixing screws 65b to form a medicine dispensing space 65a, the medicine dispensing space 65a communicating with a medicine passage 66 between the needle cover 65 and the needle fixing plate 68. The needle hole 65c is provided in the needle cover 65. The plurality of microneedles a fixed to the needle fixing plate 68 pass through the plurality of needle holes 65c, respectively, and protrude outside the needle holes 65 c.
The inner diameter of the needle hole 65c is slightly larger than the outer diameter of the microneedle a.
The size of the medicine dispensing space 65a and the size of the pinhole hole 65c are determined to satisfy the following condition: when the micro-needle 60 contacts the skin C and the blocking rod 64 opens the drug passage 66, the drug in the drug dispensing space 65a is discharged at a certain speed or amount along the micro-needle a by capillary action between the micro-needle a and the needle hole 65C; and when the microneedle 60 is spaced apart from the skin C and the blocking rod 64 closes the drug channel 66, the drug in the drug dispensing space 65a is prevented from being discharged along the microneedles a between the microneedles a and the needle holes 65C.
The fixing body 61, the medicine blocking part 63, the needle fixing plate 68, and the needle cover 65 are formed of a transparent synthetic resin material such as polymethylmethacrylate, polycarbonate, or the like, or organic glass, or the like, so that the far infrared rays generated by the far infrared ray generator 76 and the infrared rays generated by the infrared ray generator 77 are transmitted to the skin C.
After the injection of the medicine, the micro needle 60 is sealed by the needle cover 90 and stored.
Another embodiment of a microneedle according to the present invention is further described below with reference to the figures, in particular fig. 1 to 2, and fig. 14 and 15.
As shown in fig. 1, the body 2 portion of the microneedle according to the invention has a substantially cylindrical shape. As described herein, since the body 2 having the cylindrical shape partially passes through the needle hole 65c having a slightly larger inner diameter than it, as presented in fig. 14 and 15, the needle hole 65c is distributed in the needle cover 65 so that the medicine can pass through the gap between the needle hole 65c and the body 2. According to the present invention, the components constituting the micro-needle 60 include a fixing body 61, a needle fixing plate 68, and a needle cover 65, which are preferably made of synthetic resin or organic glass.
The present application performed a liquid medicine permeation test designed as follows: the micro-needle 60 is assembled as shown in fig. 7 and 8 but the heating function is not activated, which is the minimum assembly requirement for the micro-needle 60 and the micro-needle a during use; the medicine storage chamber 51 shown in fig. 7 is filled with a medicine solution; the assembled microneedle device shown in fig. 7 is pressed against a plurality of layers of absorbent paper as shown in fig. 15, the blocking rod 64 is opened so that the liquid medicine flows down into the gap between the needle hole 65c and the body 2 and further reaches the needle 1 and the groove 31 thereof, if the liquid medicine is discharged normally, the liquid medicine is adsorbed on the absorbent paper, and fine wetting points appear on the absorbent paper; if the liquid is not discharged smoothly, no liquid medicine exists on the absorbent paper; if the liquid is excessive, the wetting point is obviously increased, and at the moment, the liquid medicine amount in the needle 1 and the groove 31 thereof can be observed by means of a magnifying glass so as to judge whether the liquid medicine is excessive in seepage.
In the liquid medicine permeation test, the present inventors have found that, in the case of using the needle cover 65 made of various synthetic resins such as polymethyl methacrylate, polycarbonate, and organic glass, etc., the ability of the drug solution to pass through the gap between the needle hole 65c and the body 2 seems to be related to the pH value of the solution, and when the pH value of the solution is less than or equal to 7, the gap between the needle hole 65c and the body 2 is larger or smaller or when the body 2 is loosely or tightly inserted into the needle hole 65c, the liquid medicine can be smoothly discharged from the drug-dispensing space 65a to the needle 1 portion through the gap; however, when the pH of the solution is greater than 7, the body 2 needs to be inserted into the needle hole 65c to be able to swing left and right to smoothly discharge the solution, or the solution is only forcibly thrown toward the outlet of the solution to allow the solution to ooze. This is unacceptable because the microneedles and corresponding devices of the present invention need to be adapted for use with different fluids, particularly fluids having different pH values.
The inventor of the present invention has found through research that when a plurality of V-shaped grooves 29 are etched on the surface of the body 2 of the microneedle a in the axial direction thereof, the depth of the V-shaped grooves 29 is 1/100 to 1/10, preferably 1/75 to 1/10, preferably 1/50 to 1/15, preferably 1/40 to 1/15 of the radius of the body 2. The V-shaped groove 29 extends from the tapered shape of the body 2 at least into the medicine dispensing space 65a in the axial direction of the body 2, preferably to the other end of the body 2. In one example, in a radial cross section of the body 2, the plurality of V-shaped grooves 29 cover 1/10-1/4 regions, preferably 1/8-1/5 regions, such as 1/7-1/5 regions, of the radial surface of the body 2.
It has been found that with the design of the V-grooves 29 having a depth of 1/50-1/15 of the radius of the body 2 (too deep a V-groove affects the structural strength of the microneedle and too shallow a V-groove does not perform its function in the present invention), it is desirable that the V-groove 29 cover an area that is: when the area covered by the V-shaped groove 29 is smaller than the 1/10 area of the radial surface of the body 2, the requirement that the liquid medicine in the full acid-base area range of pH 1-13 smoothly passes through the gap between the needle hole 65c and the body 2 and seeps out to the needle 1 area to enter the groove 31 and fill the space therein cannot be realized; when the area covered by the V-shaped groove 29 is larger than the 1/4 area on the radial surface of the body 2, although the requirement that the liquid medicine in the full acid-base area range with the pH value of 1-13 smoothly passes through the gap between the needle hole 65c and the body 2 and seeps out to the needle 1 area to enter the groove 31 and fill the space therein can be realized, the obvious liquid medicine seeping-out excess can occur, so that micro-droplets existing outside the groove 31 can occur in the needle 1 area, the serious liquid medicine seeping-out excess can occur, and the part of liquid medicine can be blocked by the epidermis during injection and can not enter the skin; it is found that only when these plural V-shaped grooves 29 cover the 1/8-1/5 areas on the radial surface of the body 2, the liquid chemicals of various types and various pH can smoothly reach the grooves 31 in desired amounts.
Therefore, a plurality of V-shaped grooves 29 are etched on the surface of the body 2 of the micro needle A along the axial direction, and the depth of the V-shaped grooves 29 is 1/50-1/15 (for example, 1/40-1/15) of the radius of the body 2; and in the radial section of the body 2, the plurality of V-shaped grooves 29 cover 1/8-1/5 regions (for example, 1/7-1/5 regions) of the radial surface of the body 2. This design is extremely beneficial for various types of drugs (especially drugs in the full pH range) to smoothly and in desired amounts seep out to the needle 1 area through the gap between the needle hole 65c and the body 2.
Referring to each sub-drawing of fig. 1, (a) to (c) of fig. 1 are perspective, front and side views of the microneedle of the present application, and a plurality of V-shaped grooves 29 (exemplarily, 5 grooves are drawn) are etched on the surface of the body 2 along the axial direction thereof, and the depth of the V-shaped grooves 29 is 1/100 to 1/10, preferably 1/75 to 1/10, preferably 1/50 to 1/15, preferably 1/40 to 1/15 of the radius of the body 2. Fig. 1 (d) is a plan view of the microneedle of the present invention, wherein the plurality of V-shaped grooves 29 cover 1/10 to 1/4 regions, preferably 1/8 to 1/5 regions, for example, 1/7 to 1/5 regions of the radial surface of the body 2 in the radial cross section of the body 2. The depth of these V-shaped grooves 29 can be easily understood from the plan view of fig. 1 (d). Figure 1 (e) is a side view of a microneedle of the present invention showing the plurality of V-grooves 29 extending from the tapered shape of the body 2 in the axial direction of the body 2 to the other end of the body 2.
The above V-groove scheme is also depicted in fig. 2 herein, and differs from fig. 1 in that fig. 2 (e) is a side view of the microneedle of the present application, showing the plurality of V-grooves 29 extending from the tapered shape of the body 2 in the axial direction of the body 2 to a certain position of the body 2, the certain position to which the plurality of V-grooves 29 extend reaching at least into the drug dispensing space 65a of the microneedle 60 when the microneedle is assembled with the components of the microneedle 60, including the fixing body 61, the needle fixing plate 68, the needle cover 65, etc.
The V-groove arrangement described above may likewise be embodied in the embodiments of fig. 3-6 described herein; of course, for simplicity, these V-shaped grooves are not depicted in fig. 3-6 and their respective sub-figures.
In the chemical liquid permeation test of the present application, the synthetic resin of each member constituting the micro-needle 60 is polymethyl methacrylate, polycarbonate, or organic glass, and the results thereof can be concluded. In the liquid medicine permeation test of the present application, a 0.05M sodium chloride solution, a 0.05M citric acid/sodium citrate solution, a 0.05M acetic acid/sodium acetate solution, a commercially available elastic crystal anti-wrinkle essence, a commercially available skin-whitening, anti-wrinkle, speckle-lightening and whitening essence (the five solutions are adjusted in pH with hydrochloric acid or sodium hydroxide, respectively, to obtain 7 kinds of liquid medicine with pH values, pH1, pH3, pH5, pH7, pH9, pH11, and pH13, if necessary, filtered), and water for injection (pH7.2) are used as test liquid medicines, and the micro needle of the present application is examined to perform a liquid medicine flow test designed with V-shaped grooves 29 on the surface of the body 2, and the corresponding results as described in the present application are obtained.
In addition, the invention also provides a micro-needle injector. An exemplary microneedle injector is shown in fig. 16, which comprises: a micro-needle 60, which may be of the design according to any of the embodiments of the third aspect of the invention; a cap 91 for covering an end of the microneedle 60 where the microneedle is exposed, so that the microneedle injector protects the microneedle when not in use; and a liquid medicine bottle 92 for filling liquid medicine, wherein the open end of the liquid medicine bottle 92 is detachably and hermetically connected with one end of the fixing body 61 of the micro needle 60. In an exemplary embodiment, in order to facilitate the sealed connection between the micro needle 60 and the liquid medicine bottle 92, a connection screw 69 is disposed at one end of the micro needle 60 near the fixing body 61, and a thread matching with the connection screw 69 is disposed at the mouth of the liquid medicine bottle 92. In one embodiment, the liquid medicine bottle 92 may be made of glass, plastic, plexiglass, metal, or the like.
The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. The equivalent substitution or change made by the technical personnel in the technical field on the basis of the invention is all within the protection scope of the invention. The protection scope of the invention is subject to the claims.
Claims (13)
1. A microneedle, comprising:
a needle including an inclined portion having an inclined outer wall, a straight portion having a straight outer wall, and a groove having a depth along the inclined outer wall or the straight outer wall; and
a body coupled to the needle to move or support the needle, the body having a cylindrical shape and a tapered shape that decreases in diameter at a portion connected to the needle,
the cylindrical body is characterized in that a plurality of V-shaped grooves are etched on the surface of the cylindrical branch of the body along the axial direction of the cylindrical branch.
2. The microneedle according to claim 1,
in a radial section of the cylindrical-shaped subsection of the body, the plurality of V-shaped grooves cover 1/8-1/5 regions (e.g., 1/7-1/5 regions) of the radial surface of the body;
the depth of the V-shaped groove is 1/50-1/15 (for example 1/40-1/15) of the radius of the body; and/or
The V-shaped grooves extend from the conical shape of the body to the other end of the body along the axial direction of the body.
3. The microneedle according to claim 1,
the groove has a straight linear shape extending along the needle and is recessed toward the center of the needle by a certain depth;
the grooves are provided in three or more along the outer wall of the needle, or in four at constant intervals along the outer wall at upper, lower, left, and right sides;
the groove extends from one end of the inclined part to a part or end of the straight part and has a plurality of branch shapes;
the groove has a cross (+) shape or a flat (-) shape; and/or
The groove has a thread shape extending clockwise or counterclockwise along an outer wall of the needle.
4. A microneedle device comprising:
a medicine storage portion for storing a medicine;
a micro needle including a drug channel connected to the drug storage part, and a plurality of micro needles having a front end portion protruding from the micro needle, wherein the micro needles pierce the dermis of the skin to transfer the drug from the drug channel to the dermis of the skin when the micro needles are pressed toward the skin; and
a heating part for heating the skin through the micro needle,
wherein the microneedle is according to any one of claims 1 to 3.
5. The microneedle device according to claim 4,
the medicine storage part is formed by connecting a medicine storage chamber and a medicine supply tube to each other; and/or
The medication storage chamber includes a medication reservoir, a medication chamber, a medication selector, and at least two medication units longitudinally segregated to receive a plurality of medications.
6. The microneedle device according to claim 5,
the medication selector includes:
a hollow housing permitting rotation of the drug storage portion therein;
a shutter disposed at a lower end of the housing and including a selection hole corresponding to an outlet of one of the plurality of medicine units;
a rotor provided at an upper end of the medicine storage part; and
an upper cover closing an upper portion of the medicine storage part, supporting the rotor and allowing the rotor to rotate,
wherein the rotor rotates to rotate the drug storage portion within the housing; or,
the medication selector includes:
a hollow housing permitting rotation of the drug storage portion therein;
a plurality of medicine units including an elastic member and an opening/closing ball inside the medicine storage part;
a shutter disposed at a lower end of the housing and including a selection hole corresponding to an outlet of one of the medicine units;
a rotor provided at an upper end of the medicine storage part; and
an upper cover closing an upper portion of the medicine storage part, supporting the rotor and allowing rotation of the rotor,
wherein the rotor rotates to rotate the drug storage portion within the housing; or,
the medication selector includes:
a rotation shutter provided at a lower end portion of the medicine storage portion and capable of blocking the lower end portions of the medicine units in a rotatable manner, the rotation shutter including a selection hole corresponding to a lower end portion of one of the plurality of medicine units;
a rotor provided at an upper end of the medicine storage portion and rotatably blocking an upper end of the medicine unit; and
a rotation rod passing through the medicine storage part and connecting the rotation barrier to the rotor,
wherein, when the rotor rotates, the rotation baffle rotates with the dwang is integrative.
7. The microneedle device of claim 5, wherein said microneedle head comprises:
a stationary body forming the drug channel therein;
a needle fixing plate fixing the micro needle; and
a needle cover forming a medicine dispensing space together with the needle fixing plate to communicate with the medicine passage and including a needle hole through which the micro needle is exposed to the outside;
wherein each of the needle holes has an inner diameter slightly larger than an outer diameter of the microneedle to discharge the medicine from the medicine distribution space along the microneedle, or
The miniature syringe needle still includes medicine jam portion, medicine jam portion includes:
a blocking rod disposed inside the drug channel, the blocking rod opening the drug channel when the micro needle contacts the skin and closing the drug channel when the micro needle is spaced apart from the skin, wherein the blocking rod is movable between a first position for opening the drug channel and a second position for closing the drug channel; and
a spring elastically supporting the blocking lever to hold the blocking lever in the second position, or
The jamming rod includes:
a pressing end portion protruding to the outside more than a front end portion of the microneedle when the pressing end portion is located at the second position;
a spring seat supporting a spring between the medication passage and the spring seat; and
a blocking end blocking the drug passage in the second position, or, further
The fixing body, the needle fixing plate and the needle cover of the micro needle head are made of synthetic resin (such as polymethyl methacrylate or polycarbonate) or organic glass, or, further
The microneedle according to any of claims 1 to 3, or, further
The plurality of V-shaped grooves on the microneedle extend from the tapered shape of the body in the axial direction of the body at least into the drug dispensing space of the microneedle.
8. A micro needle, comprising:
a stationary body forming the drug channel therein;
a needle fixing plate on which a micro needle is fixed; and
a needle cover forming a medicine dispensing space together with the needle fixing plate to communicate with the medicine passage and including a needle hole through which the micro needle is exposed to the outside;
wherein each of said needle holes has an inner diameter slightly larger than an outer diameter of said microneedles to expel drug from said drug dispensing space along said microneedles,
the microneedle according to any one of claims 1 to 3.
9. The microneedle of claim 8, further comprising a drug blocking portion, said drug blocking portion comprising:
a blocking rod disposed inside the drug channel, the blocking rod opening the drug channel when the micro needle contacts the skin and closing the drug channel when the micro needle is spaced apart from the skin, wherein the blocking rod is movable between a first position for opening the drug channel and a second position for closing the drug channel; and
a spring elastically supporting the blocking lever to maintain the blocking lever at the second position.
10. The microneedle of claim 8, wherein said blocking rod comprises:
a pressing end portion protruding to the outside more than a front end portion of the microneedle when the pressing end portion is located at the second position;
a spring seat supporting a spring between the medication passage and the spring seat; and
a blocking end blocking the drug passage in the second position, or, further
The fixing body, the needle fixing plate and the needle cover are made of synthetic resin (such as polymethylmethacrylate or polycarbonate) or organic glass, or, further
The plurality of V-shaped grooves on the microneedle extend from the tapered shape of the body in the axial direction of the body at least into the drug dispensing space of the microneedle.
11. A microneedle injector, characterized by comprising:
a microneedle according to any one of claims 8 to 10;
a cap for covering one end of the microneedle, at which the microneedle is exposed, so that the microneedle injector protects the microneedle when not in use;
and the opening end of the liquid medicine bottle is detachably and hermetically connected with one end of the fixing body of the micro needle head.
12. A microneedle injector as claimed in claim, wherein the said liquid bottle is in screw-type sealing connection with the said miniature needle.
13. A microneedle injector as claimed in claim, wherein the liquid bottle is made of a material selected from glass, plastic, plexiglass, and metal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056980.2A CN106345051A (en) | 2016-11-25 | 2016-11-25 | Miniature injection needle and integrated device thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056980.2A CN106345051A (en) | 2016-11-25 | 2016-11-25 | Miniature injection needle and integrated device thereof |
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| Publication Number | Publication Date |
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| CN106345051A true CN106345051A (en) | 2017-01-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611056980.2A Pending CN106345051A (en) | 2016-11-25 | 2016-11-25 | Miniature injection needle and integrated device thereof |
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| CN (1) | CN106345051A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109789301A (en) * | 2017-03-24 | 2019-05-21 | 李昌雨 | Needle plate seal |
| CN110270006A (en) * | 2019-07-11 | 2019-09-24 | 上海揽微医学科技有限公司 | Prismatic metal micro-needle and preparation method thereof |
| CN111317911A (en) * | 2020-02-28 | 2020-06-23 | 广东工业大学 | Novel microneedle and manufacturing method thereof |
| CN111526918A (en) * | 2017-12-26 | 2020-08-11 | 三岛光产株式会社 | Microneedle array |
| CN112135597A (en) * | 2018-05-11 | 2020-12-25 | 百时美施贵宝公司 | Combination Drug Delivery Device |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935096A (en) * | 1994-09-02 | 1999-08-10 | Oversby Pty Ltd. | Grooved phaco-emulsification needle |
| US20090131887A1 (en) * | 2006-07-04 | 2009-05-21 | Toppan Printing Co., Ltd. | Method of manufacturing microneedle |
| JP2012157406A (en) * | 2011-01-29 | 2012-08-23 | Asti Corp | Microneedle, microneedle array, and microneedle array device |
| JP2012170784A (en) * | 2011-02-24 | 2012-09-10 | Terumo Corp | Needle assembly |
| CN102844072A (en) * | 2010-01-29 | 2012-12-26 | 优比欧迈德有限公司 | Micro needle and micro needle device |
| CN105381536A (en) * | 2015-12-22 | 2016-03-09 | 无锡吉迈微电子有限公司 | Automatic-medicine-carrying long-time transdermal-delivery and sampling device |
| CN206950455U (en) * | 2016-11-25 | 2018-02-02 | 崔丽林 | Micro-injection pin and by its integrated device |
| CN108290031A (en) * | 2015-09-17 | 2018-07-17 | Ａｏｆ株式会社 | Micropin |
-
2016
- 2016-11-25 CN CN201611056980.2A patent/CN106345051A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935096A (en) * | 1994-09-02 | 1999-08-10 | Oversby Pty Ltd. | Grooved phaco-emulsification needle |
| US20090131887A1 (en) * | 2006-07-04 | 2009-05-21 | Toppan Printing Co., Ltd. | Method of manufacturing microneedle |
| CN102844072A (en) * | 2010-01-29 | 2012-12-26 | 优比欧迈德有限公司 | Micro needle and micro needle device |
| JP2012157406A (en) * | 2011-01-29 | 2012-08-23 | Asti Corp | Microneedle, microneedle array, and microneedle array device |
| JP2012170784A (en) * | 2011-02-24 | 2012-09-10 | Terumo Corp | Needle assembly |
| CN108290031A (en) * | 2015-09-17 | 2018-07-17 | Ａｏｆ株式会社 | Micropin |
| CN105381536A (en) * | 2015-12-22 | 2016-03-09 | 无锡吉迈微电子有限公司 | Automatic-medicine-carrying long-time transdermal-delivery and sampling device |
| CN206950455U (en) * | 2016-11-25 | 2018-02-02 | 崔丽林 | Micro-injection pin and by its integrated device |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109789301A (en) * | 2017-03-24 | 2019-05-21 | 李昌雨 | Needle plate seal |
| CN109789301B (en) * | 2017-03-24 | 2021-03-12 | 李昌雨 | Needle plate stamp |
| CN111526918A (en) * | 2017-12-26 | 2020-08-11 | 三岛光产株式会社 | Microneedle array |
| CN111526918B (en) * | 2017-12-26 | 2022-03-29 | 三岛光产株式会社 | Microneedle array |
| US11801372B2 (en) | 2017-12-26 | 2023-10-31 | Mishima Kosan Co., Ltd. | Microneedle array |
| CN112135597A (en) * | 2018-05-11 | 2020-12-25 | 百时美施贵宝公司 | Combination Drug Delivery Device |
| CN110270006A (en) * | 2019-07-11 | 2019-09-24 | 上海揽微医学科技有限公司 | Prismatic metal micro-needle and preparation method thereof |
| CN110270006B (en) * | 2019-07-11 | 2022-03-01 | 上海揽微医学科技有限公司 | Prismatic metal microneedle and preparation method thereof |
| CN111317911A (en) * | 2020-02-28 | 2020-06-23 | 广东工业大学 | Novel microneedle and manufacturing method thereof |
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Application publication date: 20170125 |
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