KR102060426B1 - Pumping type toothpaste composition - Google Patents
Pumping type toothpaste composition Download PDFInfo
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- KR102060426B1 KR102060426B1 KR1020170010589A KR20170010589A KR102060426B1 KR 102060426 B1 KR102060426 B1 KR 102060426B1 KR 1020170010589 A KR1020170010589 A KR 1020170010589A KR 20170010589 A KR20170010589 A KR 20170010589A KR 102060426 B1 KR102060426 B1 KR 102060426B1
- Authority
- KR
- South Korea
- Prior art keywords
- pump
- toothpaste composition
- composition
- toothpaste
- type
- Prior art date
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 118
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 117
- 239000000203 mixture Substances 0.000 title claims abstract description 116
- 238000005086 pumping Methods 0.000 title description 3
- 239000011230 binding agent Substances 0.000 claims description 35
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 11
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 11
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 11
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 11
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 11
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 11
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 11
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- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
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- ATGAWOHQWWULNK-UHFFFAOYSA-I pentapotassium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [K+].[K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O ATGAWOHQWWULNK-UHFFFAOYSA-I 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
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- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
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- 229960003080 taurine Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940095688 toothpaste product Drugs 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 펌프형 용기에 담지해 제공 가능한 펌프형 치약 조성물에 관한 것으로서, 칫솔에 토출된 치약 조성물이 칫솔 속으로 스며들어 치아에 대한 발림성이 개선되고, 궁극적으로는 구강 내에서 오랫동안 지속적으로 약효성분 전달이 가능한 효과가 있는 펌프형 치약 조성물에 관한 것이다. The present invention relates to a pump-type toothpaste composition that can be supported on a pump-type container, wherein the toothpaste composition discharged to the toothbrush penetrates into the toothbrush, improving the application of teeth, and ultimately, the active ingredient for a long time in the oral cavity. It relates to a pump-type toothpaste composition having an effect capable of delivery.
Description
본 발명은 치약 조성물에 관한 것으로, 펌핑형 용기에 담지하여 제공되기 위한 치약 조성물로서, 칫솔 속으로 치약 조성물이 스며들어 치아에 대한 발림성이 개선된 치약 조성물에 관한 것이다. The present invention relates to a toothpaste composition, which is provided in a pumped container to be provided in a toothpaste composition, the toothpaste composition is permeated into the toothbrush relates to a toothpaste composition with improved tooth spreadability.
구강 및 치아의 세정을 위해 통상적으로 사용되는 치약 조성물은 페이스트상, 분말상, 젤상/점액상 또는 액상으로 된 제품이 유통되고 있고, 그 사용 및 취급상에는 일정한 장단점이 있다. Toothpaste compositions commonly used for cleaning mouths and teeth are in the form of paste, powder, gel / mucus, or liquid products, which have certain advantages and disadvantages in their use and handling.
미국 콜게이트사에서 최초 개발된 페이스트상 치약은 알루미늄 튜브에 담겨 판매되었고 1970년대까지도 이러한 알루미늄 튜브를 사용하고 있었다. 이러한 페이스트상 치약의 용기가 현대와 같이 알루미늄이 적층필름 재질로 개발된 것은 고분자 및 고분자 가공 기술의 발전으로 이루어진 것이라 할 수 있다. 그러나 이러한 튜브형태의 치약은 점도가 높고 연마제 성분에 의한 치아 에나멜층의 손상을 유발시킬 가능성이 높고 사용시에 짜내기가 불편할 뿐만 아니라 용기내의 제품을 완벽하게 사용할 수 없어서 폐기되는 용기에도 잔량의 치약이 남게 되고 환경오염을 유발시키는 문제점이 있는 등 여러가지 불편이 많은 것이 현실이다. 이러한 치약의 풀림성 등을 개선하기 위하여 플라스틱 용기에 흐르는 특성을 가지는 액상 치약 제품이 출시되었으나 너무 잘 흐르는 경우 칫솔 위에서 흘러 치약제품 내에 약물을 치아 및 잇몸에 효과적으로 전달하는데 어려움이 있다. 이에, 구강균의 억제 및 구취 제거의 기능을 수행하는 구강 가글제로서 널리 사용되고 있으나 세정성분이 부족하고 쉽게 흘러내리는 문제점으로 인해 구강내 플라그의 제거 및 구강균 제거 등의 충분한 양치질의 효과를 발휘할 수 없었다. 소비자의 사용자 편리성 증진을 위하여 다음으로 적용된 것이 진공펌프 형의 플라스틱 용기를 적용하여 고점도의 페이스트를 토출할 수 있도록 하는 시도가 있었으며, 일부 제품은 시판중에 있으나 가격적인 문제 및 기존 페이스트 치약의 풀림성이 약한 특성 등이 상존하고 있다. 또한, 분말상은 그 사용중에 입자가 분사되거나 비산되므로 사용상에 불편함이 있다. Paste toothpaste, first developed by Colgate in the United States, was sold in aluminum tubes, which were used until the 1970s. The container of paste-like toothpaste, which is developed as a laminated film material as in modern times, can be said to be made by the development of polymer and polymer processing technology. However, the tube-type toothpaste has a high viscosity, is likely to cause damage to the tooth enamel layer due to the abrasive component, it is inconvenient to squeeze out of use, and the remaining amount of toothpaste remains in the container discarded because the product in the container cannot be used completely. It is a reality that there are many inconveniences such as problems that cause environmental pollution. In order to improve the loosening properties of the toothpaste, such as liquid toothpaste products having flow characteristics in a plastic container has been released, but if flows too well, it is difficult to effectively deliver the drug in the toothpaste product to the teeth and gums flowing on the toothbrush. Thus, although it is widely used as an oral goggle agent to perform the function of suppression of oral bacteria and bad breath removal, due to the problem of lacking cleaning components and easily flowing down, it was not possible to exert sufficient brushing effect such as removing oral plaque and removing oral bacteria. In order to enhance consumer convenience, the next application was to apply a vacuum pump-type plastic container to discharge high-viscosity pastes. Some products are commercially available, but there are price issues and loosening of existing paste toothpaste. This weak characteristic is present. In addition, the powder phase is inconvenient in use because particles are sprayed or scattered during its use.
이에, 본 발명이 해결하고자 하는 과제는, 상술한 문제를 해결하고, 펌프형 용기에 담지해 제공 가능한 펌프형 치약 조성물을 제공하기 위한 것이다. Accordingly, the problem to be solved by the present invention is to solve the above-described problems, and to provide a pump-type toothpaste composition that can be supported on the pump-type container.
또한, 펌프형 치약 조성물로서, 칫솔에 토출된 치약 조성물이 칫솔 속으로 스며들어 치아에 대한 발림성이 개선된 치약 조성물을 제공하기 위한 것이다. In addition, the pump-type toothpaste composition, the toothpaste composition discharged to the toothbrush penetrates into the toothbrush to provide a toothpaste composition with improved tooth spreadability.
상술한 과제를 해결하기 위하여, 본 발명은 펌프형 용기에 담지해 제공 가능한 펌프형 치약 조성물을 제공한다. 보다 구체적으로, 펌프형 치약 조성물로서, 칫솔에 토출된 치약 조성물이 칫솔 속으로 스며들어 치아에 대한 발림성이 개선된 치약 조성물을 제공한다. In order to solve the above problems, the present invention provides a pump-type toothpaste composition that can be provided on a pump-type container. More specifically, as a pump-type toothpaste composition, the toothpaste composition discharged to the toothbrush penetrates into the toothbrush, thereby providing a toothpaste composition having improved tooth spreadability.
이하, 보다 상세히 기술한다. It is described in more detail below.
칫솔에 토출해 사용하는 치약은 칫솔에 잘 스며들어 칫솔질을 하는 동안 치아에 지속적으로 약효성분을 전달할 수 있도록 제조되는 것이 중요하다. 따라서, 흐름성이 너무 강하면 칫솔 위에서 치약이 흘러버리고, 고점도이거나 탄성계수가 높은 치약은 풀림성이 약하고 치아에 닿는 순간 모두 소진되버리는 단점을 해소하는 것이 필요하다. 아울러, 칫솔 안으로 스며들되, 동시에 양치시에는 풍만감을 느낄 수 있을 정도의 기포감이 제공되는 치약 조성물을 제조하는 것이 중요하나, 이러한 치약 조성물 제조에 어려움이 있었다. It is important that toothpaste dispensed on a toothbrush is used to penetrate the toothbrush and continuously deliver the active ingredient to the tooth while brushing. Therefore, if the flow is too strong, it is necessary to solve the disadvantage that toothpaste flows on the toothbrush, and the toothpaste having high viscosity or high modulus of elasticity is loosened and exhausted at the moment of touching the tooth. In addition, it is important to prepare a toothpaste composition that is permeated into the toothbrush, but at the same time provides a feeling of bubble enough to feel a voluptuous when brushing teeth, there was a difficulty in preparing such a toothpaste composition.
이에, 본 발명자들은 펌프형 용기에 담지되는 펌프형 치약 조성물에서 사용하는 결합제의 종류 및/또는 함량을 조절함으로써, 펌프형 치약 조성물이 칫솔모 사이에 잘 스며들어 치아에 대한 발림성 개선에 현저한 효과가 있고 이로써 오랫동안 치아에 지속적으로 약효성분을 전달하는 우수한 효과가 있으며, 이에 더불어 양치시 풍만감을 제공하는 효과가 있음을 발견하고 본 발명을 완성하였다. Thus, the present inventors by controlling the type and / or content of the binder used in the pump-type toothpaste composition carried in the pump-type container, the pump-type toothpaste composition soaks well between the bristles and has a remarkable effect on improving the applicability to teeth As a result, there is an excellent effect of continuously delivering the active ingredient to the teeth for a long time, and in addition, found that there is an effect of providing a voluptuous feeling when brushing the teeth and completed the present invention.
보다 구체적으로, 펌프형 치약 조성물에서 결합제의 함량을 조성물의 총 중량 대비 0.1 중량% 이상 2.5 중량% 미만으로 포함하거나, 또는 결합제로써 PVM/MA, PVP, HPMC, 및 HPC로 이루어진 군에서 선택된 1종 이상을 사용하는 경우, 치아에 대한 발림성 개선 및 풍만한 양치감 제공이 가능함을 확인하였다. More specifically, the content of the binder in the pump-type toothpaste composition comprises 0.1% to 2.5% by weight relative to the total weight of the composition, or as a binder selected from the group consisting of PVM / MA, PVP, HPMC, and HPC In the case of using the above, it was confirmed that the improvement of applicability to teeth and the provision of a voluminous brushing feeling were possible.
본 발명에 따른 명세서에 있어서, 용어 '펌프형'은 용기의 누름부를 이용한 펌프작용을 통해 용기 내부에 저장된 내용물을 토출구를 통하여 외부로 간단히 배출시킬 수 있는 구조를 말한다. 구체적으로 용기 내부에 있는 치약 조성물을 피스톤의 펌프작용을 통해 용기 외부로 배출시켜 사용하는 구조를 의미하며, 즉, 상기펌프작용으로 용기 내부에 장착된 피스톤에 의해서 내용물이 용기의 내부 하단에서 외부로 배출될 수 있다.In the specification according to the present invention, the term 'pump type' refers to a structure that can simply discharge the contents stored inside the container to the outside through the discharge port through the pump action using the pressing portion of the container. Specifically, it means a structure that discharges the toothpaste composition inside the container to the outside of the container through the pumping action of the piston, that is, the contents from the inner bottom of the container to the outside by the piston mounted inside the container by the pumping action. May be discharged.
본 발명은 펌프형 용기에 담지되는 펌프형 치약 조성물로서, 특정 함량 범위 및/또는 특정 종류의 결합제를 포함하는 펌프형 치약 조성물을 제공한다. The present invention provides a pump-type toothpaste composition carried in a pump-type container, the pump-type toothpaste composition comprising a specific content range and / or a specific kind of binder.
상기 '결합제'는 치약이 안정하고 균일한 형태를 유지하게 하는 성분을 말하고, 당업계 통상적으로 치약 조성물에 결합제로서 통상 사용 가능한 다양한 성분이 포함될 수 있다. 예컨대, 카르복시메틸셀룰로오스나트륨, 메틸비닐에텔과 말레익안하이드라이드의 공중합체(PVM/MA), 폴리비닐피롤리돈(PVP), 하이드록시프로필메틸셀룰로오스(HPMC), 하이드록시메틸셀룰로오스(HMC), 하이드록시프로필셀룰로오스(HPC), 카보머, 카라기난, 잔탄검, 구아검, 폴리아크릴산/나트륨 및 알지네이트류 등이 포함되며, 이에 제한되지 않는다. 결합제로써의 기능과 함께 다른 기능을 발휘하는 성분도 본 발명에서 정의하는 결합제에 포함되며 배제되지 않는 것으로 해석한다. The 'binder' refers to a component that allows the toothpaste to maintain a stable and uniform form, and may include various components conventionally used as a binder in a toothpaste composition. For example, sodium carboxymethyl cellulose, copolymers of methyl vinyl ether and maleic hydride (PVM / MA), polyvinylpyrrolidone (PVP), hydroxypropylmethyl cellulose (HPMC), hydroxymethyl cellulose (HMC), Hydroxypropyl cellulose (HPC), carbomer, carrageenan, xanthan gum, guar gum, polyacrylic acid / sodium and alginates, and the like. Ingredients that perform other functions in addition to their function as binders are also included in the binders defined in the present invention and are interpreted as not being excluded.
본 발명에 따른 펌프형 치약 조성물은 겔상으로 제공된다. The pump toothpaste composition according to the present invention is provided in a gel form.
본 발명에 따른 명세서에 있어서, 용어 '겔상'은 기존의 묽은 제형의 액상 치약 및 고점도의 페이스트 치약는 구별하기 위한 개념으로 사용된 것이다. 상기 겔상은 기존 액상 제형과는 차별되는 제형으로, 액상치약에 비해서 끈적이는 정도가 크고, 점성이 있는 제형을 의미한다. 본 발명의 겔상의 치약은 탄성이 있으며, 액상 치약에 비해 견고성이 있는 제형을 의미한다. 또한, 본 발명의 겔상 치약은 페이스트형의 치약에 비해서는 점도가 낮아서 유동성이 있고, 흐름성이 있어 내용물을 외부로 용이하게 토출할 수 있다. In the specification according to the present invention, the term 'gel' is used as a concept for distinguishing between the liquid toothpaste of the conventional thin formulation and the paste paste of high viscosity. The gel phase is a formulation that is different from the conventional liquid formulation, and refers to a viscous formulation having a greater stickiness than the liquid toothpaste. Gel toothpaste of the present invention refers to a formulation that is elastic and firmer than liquid toothpaste. In addition, the gel toothpaste of the present invention has a lower viscosity than the paste-type toothpaste, has fluidity, and has flowability, so that the contents can be easily discharged to the outside.
본 발명에 따른 명세서에 있어서, 용어 '탄성'은 외부 힘에 의하여 변형을 일으킨 물체가 힘이 제거되었을 때 원래의 모양으로 되돌아 가려는 성질을 의미하는 것으로서, 원래의 형태를 유지하려고 하는 물체의 특성을 의미하는 넓은 개념으로 사용되었다. 즉, 치약 조성물을 토출구에서 토출한 후에 최초 모양을 유지하려고 하는 모든 성질을 포함하는 넓은 의미로 사용되었다. In the specification according to the present invention, the term 'elasticity' refers to a property of the object caused by the external force to return to its original shape when the force is removed, it is characterized by the characteristics of the object to maintain the original shape It is used as a broad concept. In other words, the toothpaste composition was used in a broad sense including all the properties to maintain the original shape after the discharge from the discharge port.
일 양태로, 본 발명은 펌프형 용기에 담지되는 펌프형 치약 조성물로서, 메틸비닐에텔과 말레익안하이드라이드의 공중합체(PVM/MA), 폴리비닐피롤리돈(PVP), 하이드록시프로필메틸셀룰로오스(HPMC), 및 하이드록시프로필셀룰로오스(HPC)(이하, 4종이라 칭함)로 이루어진 군에서 선택된 1이상의 결합제를 포함하는 것을 특징으로 하는, 펌프형 치약 조성물을 제공한다. In one aspect, the present invention is a pump-type toothpaste composition carried in a pump-type container, a copolymer of methyl vinyl ether and maleic hydride (PVM / MA), polyvinylpyrrolidone (PVP), hydroxypropyl methyl cellulose (HPMC), and at least one binder selected from the group consisting of hydroxypropyl cellulose (HPC) (hereinafter referred to as four species), provides a pump-type toothpaste composition.
본 발명에 있어서, 결합제로써 상기 4종 중 1이상을 사용한다면, 이들 결합제 외에, 선택적으로 결합제로 당업계에 공지된 그 외의 결합제를 추가하여 사용할 수 있다. 그 외의 결합제에는 상술한 예로, 카르복시메틸셀룰로오스나트륨, 카보머, 카라기난, 잔탄검, 구아검, 폴리아크릴산/나트륨 및 알지네이트류 등이 포함되며, 이에 제한되지 않는다. In the present invention, if one or more of the above four kinds are used as the binder, in addition to these binders, other binders known in the art may be optionally used as the binder. Other binders include, but are not limited to, the aforementioned examples, carboxymethylcellulose sodium, carbomer, carrageenan, xanthan gum, guar gum, polyacrylic acid / sodium and alginates.
상기 4종 중 1이상의 결합제 총 함량은 펌프형 치약 조성물의 총 중량 대비 0.1 - 7 중량%, 보다 바람직하게 0.3-5 중량%, 보다 더 바람직하게 0.5-2.5 중량% 포함할 수 있다. 상기 범위 내의 함량으로 결합제를 사용하면 적절한 점도의 치약 조성물을 제조할 수 있고, 칫솔모 간극에 잘 스며드는 치약 조성물 제조가 가능한 효과가 있다. The total content of at least one of the four kinds may include 0.1-7 wt%, more preferably 0.3-5 wt%, even more preferably 0.5-2.5 wt%, based on the total weight of the pump toothpaste composition. When the binder is used in an amount within the above range, a toothpaste composition having an appropriate viscosity can be prepared, and the toothpaste composition penetrating into the bristle gap can be produced.
상기 4종 중 1이상의 결합제를 포함해 본 발명에 따른 치약 조성물에 포함되는 결합제의 총 함량은 펌프형 치약 조성물의 총 중량 대비 0.5 - 8 중량%, 보다 바람직하게 0.5-6 중량%, 보다 더 바람직하게 0.5-5 중량% 포함할 수 있다. 상기 범위 내의 함량으로 결합제를 사용하면 적절한 점도의 치약 조성물을 제조할 수 있고, 칫솔모 간극에 잘 스며드는 치약 조성물 제조가 가능한 효과가 있다. The total content of the binder included in the dentifrice composition according to the present invention, including one or more of the above four kinds of binders, is 0.5-8% by weight, more preferably 0.5-6% by weight, even more preferably based on the total weight of the pump-type toothpaste composition. It may contain 0.5-5% by weight. When the binder is used in an amount within the above range, a toothpaste composition having an appropriate viscosity can be prepared, and the toothpaste composition penetrating into the bristle gap can be produced.
본 발명에 따른 상기 4종 중 1이상의 결합제를 포함하는 펌프형 치약 조성물은, 칫솔모와 칫솔모 사이의 간격이 1-1.5mm 인 칫솔에 토출 하였을 때 10초 이내에 칫솔 간극 사이로 1.5mm 이상의 깊이로 스며든다. 보다 바람직하게, 5 mm 이하의 깊이로 스며든다. 상기 용어 '깊이'는 칫솔모의 상단에서 치약이 하단으로 전개하는 길이를 의미한다. Pump-type toothpaste composition comprising at least one of the four kinds of binders according to the present invention, when discharged to the toothbrush between the bristles and the bristles bristle 1 to 1.5mm within 10 seconds soaking into a depth of more than 1.5mm between the toothbrush gap. More preferably, it soaks to a depth of 5 mm or less. The term 'depth' means the length of the toothpaste from the top of the brush head to the bottom.
본 발명에 따른 상기 4종 중 1이상의 결합제를 포함하는 펌프형 치약 조성물은, 상온(25℃)에서 점도가 5 X 103 cP 이상 60 X 103 cP 미만이다. 상기 점도는 당업계 공지된 다양한 방법에 의해 측정할 수 있으며, 예컨대 브룩필드점도계 RVT형으로 스핀들 7번을 이용하여 분당 10회전의 회전속도로 회전하면서 측정할 수 있고, 이에 제한되지 않는다. Pump type toothpaste composition comprising at least one of the above four kinds of binders according to the present invention has a viscosity of 5 X 10 3 cP or more and less than 60 X 10 3 cP at room temperature (25 ° C). The viscosity can be measured by a variety of methods known in the art, for example, Brookfield viscometer RVT type using a spindle number 7 can be measured while rotating at a rotational speed of 10 revolutions per minute, without being limited thereto.
본 발명에 따른 상기 4종 중 1이상의 결합제를 포함하는 펌프형 치약 조성물은, Tan δ (Loss modulus(손실계수)(G”)/Elastic Modulus(탄성계수)(G')가 0.4 이상이다. 본 발명은, 점성계수가 높은 고분자인 상기 4종을 사용하면서도, 동시에 우수한 흐름성을 가져, 풍만감이 우수한 치약 조성물을 제공한다. In the pump-type toothpaste composition comprising at least one of the four kinds of binders according to the present invention, Tan δ (Loss modulus (G ') / Elastic Modulus (G') is 0.4 or more. The present invention provides the dentifrice composition having excellent viscous feeling while using the four kinds of polymers having high viscosity coefficients and at the same time having excellent flowability.
본 발명에 따른 상기 4종 중 1이상의 결합제를 포함하는 펌프형 치약 조성물은, 우수한 풍만감을 발휘한다. Pump-type toothpaste composition comprising at least one of the above four kinds of binders according to the present invention exhibits excellent voluminous feel.
본 발명에 따른 명세서에 있어서, 용어 '풍만감'은 양치시 발생하는 기포의 질감과 점도로 인해 입안 그득한 감각을 칭한다. In the specification according to the present invention, the term 'fullness' refers to a full sense of mouth due to the texture and viscosity of bubbles generated when brushing teeth.
또 다른 양태로, 본 발명은 펌프형 용기에 담지되는 펌프형 치약 조성물로서, 결합제의 함량이 조성물의 총 중량 대비 0.5 중량% 이상인 것을 특징으로 하는, 펌프형 치약 조성물을 제공한다. 보다 바람직하게, 조성물의 총 중량 대비 2.5 중량% 미만이다. 더욱 더 바람직하게, 조성물의 총 중량 대비 1.5 중량% 이하이다. 조성물의 총 중량 대비 2.5 중량% 이상의 경우, 칫솔모에 잘 스며들지 않고 고점도인 치약 조성물이 제조된다. In another aspect, the present invention provides a pump-type toothpaste composition supported on the pump-type container, characterized in that the content of the binder is at least 0.5% by weight based on the total weight of the composition. More preferably, less than 2.5% by weight relative to the total weight of the composition. Even more preferably, it is 1.5% by weight or less based on the total weight of the composition. At least 2.5% by weight relative to the total weight of the composition, a toothpaste composition having a high viscosity without penetrating the bristles is prepared.
상기 결합제에는 당업계 치약 조성물의 결합제로 공지된 결합제가 사용될 수 있으며, 예컨대, 카르복시메틸셀룰로오스나트륨, 메틸비닐에텔과 말레익안하이드라이드의 공중합체(PVM/MA), 폴리비닐피롤리돈(PVP), 하이드록시프로필메틸셀룰로오스(HPMC), 하이드록시메틸셀룰로오스(HMC), 하이드록시프로필셀룰로오스(HPC), 카보머, 카라기난, 잔탄검, 구아검, 폴리아크릴산/나트륨 및 알지네이트류 등이 사용될 수 있다. 바람직하게, 카르복시메틸셀룰로오스나트륨, 카보머, 카라기난, 잔탄검, 구아검, 폴리아크릴산/나트륨 및 알지네이트류 중 1이상이 사용될 수 있다. The binder may be a binder known as a binder of a toothpaste composition in the art, for example, sodium carboxymethylcellulose, a copolymer of methyl vinyl ether and maleic hydride (PVM / MA), polyvinylpyrrolidone (PVP) , Hydroxypropylmethyl cellulose (HPMC), hydroxymethyl cellulose (HMC), hydroxypropyl cellulose (HPC), carbomer, carrageenan, xanthan gum, guar gum, polyacrylic acid / sodium, alginates and the like. Preferably, at least one of sodium carboxymethylcellulose, carbomer, carrageenan, xanthan gum, guar gum, polyacrylic acid / sodium and alginates can be used.
본 발명에 따른 조성물의 총 중량 대비 0.5 중량% 이상의 결합제를 포함하는 펌프형 치약 조성물은, 칫솔모와 칫솔모 사이의 간격이 1.5mm 인 칫솔에 토출 하였을 때 10초 이내에 칫솔 간극 사이로 1mm 이상의 깊이로 스며든다. 또한, 칫솔모와 칫솔모 사이의 간격이 2mm 인 칫솔에 토출 하였을 때 10초 이내에 칫솔 간극 사이로 1.5 이상의 깊이로 스며든다. 상기 용어 '깊이'는 칫솔모의 상단에서 치약이 하단으로 전개하는 길이를 의미한다. The pump-type toothpaste composition comprising a binder at least 0.5% by weight relative to the total weight of the composition according to the present invention is soaked to a depth of 1 mm or more between toothbrush gaps within 10 seconds when discharged to a toothbrush having a bridging distance between the bristles and the bristles. In addition, when discharging the toothbrush between the bristles and the bristles is 2mm, soaking to a depth of 1.5 or more between the toothbrush gap within 10 seconds. The term 'depth' means the length of the toothpaste from the top of the brush head to the bottom.
본 발명에 따른 조성물의 총 중량 대비 0.5 중량% 이상의 결합제를 포함하는 펌프형 치약 조성물은, 상온(25℃)에서 점도가 5 X 103 cP 이상 40 X 103 cP 이하이다. 상기 점도는 당업계 공지된 다양한 방법에 의해 측정할 수 있으며, 예컨대 브룩필드점도계 RVT형으로 스핀들 7번을 이용하여 분당 20회전의 회전속도로 회전하면서 측정할 수 있고, 이에 제한되지 않는다. Pump type toothpaste composition comprising a binder at least 0.5% by weight relative to the total weight of the composition according to the present invention, the viscosity at room temperature (25 ℃) 5 X 10 3 cP or more 40 X 10 3 cP or less. The viscosity can be measured by a variety of methods known in the art, for example, Brookfield viscometer RVT type can be measured while rotating at a rotational speed of 20 revolutions per minute using a spindle number 7, but is not limited thereto.
본 발명에 따른 치약 조성물은 결합제 외에, 당업계에 치약 조성물로서 통상적으로 사용되는 성분들로, 그 제현 및 사용 목적에 따라, 착향제, 감미제, 약효제, pH조정제, 방부제, 결합제, 기포제, 증백제 등을 더 포함할 수 있다.Toothpaste composition according to the present invention is a component commonly used as a toothpaste composition in the art, in addition to the binder, according to the expression and purpose of use, flavoring agent, sweetening agent, agonist, pH adjuster, preservative, binder, foaming agent, thickening It may further include a bleach.
바람직하게, 본 발명에 따른 치약 조성물은 펌프형 치약 조성물로 제공되는바, 펌프 마모 방지를 위해 연마제는 소량 포함하는 것이 바람직하며, 건조에 의한 토출구 막힘 현상을 방지하기 위해 윤활제(폴리올, 글리세린 등)를 포함하는 것이 바람직하다. Preferably, the toothpaste composition according to the present invention is provided as a pump-type toothpaste composition, it is preferable to include a small amount of abrasives to prevent pump abrasion, lubricants (polyol, glycerin, etc.) to prevent the discharge port clogging phenomenon by drying It is preferable to include.
연마제는 구강 내에서 치태(플라그)를 제거하는 기능을 하는 물질로써, 치아 플라그의 제거 효율을 높이고 단단한 이물 등을 제거하기 위하여 필수적으로 사용되며, 모스 경도가 3~6 정도의 값을 나타낸다. 본 발명에 있어서, 펌프 용기의 피스톤이 저밀도 폴리에틸렌으로 제작되며, 상기 폴리에틸렌의 경도는 사용되는 연마제의 경도보다 낮기 때문에 펌프가 마모될 수 있으므로, 연마제는 소량 포함하는 것이 바람직하다. 예컨대, 조성물의 총 중량 대비 30 중량% 이하, 바람직하게는 0.5 내지 20 중량% 포함될 수 있다. 상기 연마제는 예컨대 인산일수소칼슘, 침강 실리카, 흄드실리카, 콜로이드성 실리카, 제올라이트, 탄산 칼슘, 함수 알루미나, 카오린, 셀룰로오스 및 이들의 혼합물로 이루어진 군에서 선택된 어느 하나를 포함할 수 있으나, 이에 제한되지 않는다. The abrasive is a material that functions to remove plaque in the oral cavity, and is used to increase the removal efficiency of the dental plaque and to remove hard foreign matters, and has a Mohs hardness of about 3-6. In the present invention, the piston of the pump container is made of low-density polyethylene, and since the hardness of the polyethylene is lower than that of the abrasive used, the pump may wear out, and therefore it is preferable to include a small amount of abrasive. For example, 30 wt% or less, preferably 0.5 to 20 wt% of the total weight of the composition may be included. The abrasive may include, for example, any one selected from the group consisting of calcium hydrogen phosphate, precipitated silica, fumed silica, colloidal silica, zeolite, calcium carbonate, hydrous alumina, kaolin, cellulose, and mixtures thereof. It doesn't work.
윤활제는 서로 접촉해서 미끄러지는 두면 사이의 마찰을 줄이는 작용을 하는 물질을 의미하며, 윤활제는 윤활작용을 하여 본 발명의 치약 조성물 중에 함유되어 있는 마모 특성을 나타내는 원료(연마제 등 고형분)에 의한 피스톤의 마모를 방지하는 역할을 한다. 상기 윤활제는 예컨대 폴리에틸렌글리콜, 글리세롤, 프로필렌글리콜, 에틸렌글리콜, 폴리프로필렌글리콜 및 이들의 혼합물로 이루어진 군에서 선택된 어느 하나를 포함할 수 있으나 이에 제한되지 않는다. 바람직하게는 폴리에틸렌글리콜 200 내지 600, 글리세롤, 프로필렌글리콜, 에틸렌글리콜, 폴리프로필렌글리콜 및 이들의 혼합물로 이루어진 군에서 선택된 어느 하나를 포함할 수 있다. 바람직하게는 액상 윤활제로, 석유계 기름, 동식물유, 합성윤활유 등이 이용될 수 있으며, 가장 바람직하게는 조성물의 안정성 및 우수한 사용감 측면에서 액상 폴리올을 사용할 수 있다. 또는, 윤활제는 액상 폴리올에 한정되지 않고, 고분자의 형태를 갖는 폴리에틸렌글리콜, 폴리프로필렌글리콜 같이 일정 분자량 이상에서 고분자의 내부인력(intramolecular interaction)에 의하여 상온에서 고상으로 존재할 수 있지만 제조 온도의 조절을 통하여 액화가 가능하고 제품화하여 안정된 상태로 유지될 수 있는 고분자량 폴리올도 포함한다. Lubricant refers to a substance that acts to reduce friction between two surfaces that come into contact with each other and slip, and a lubricant refers to a piston made of a raw material (a solid component such as an abrasive) that lubricates and exhibits wear characteristics contained in the toothpaste composition of the present invention. It serves to prevent wear. The lubricant may include, but is not limited to, any one selected from the group consisting of polyethylene glycol, glycerol, propylene glycol, ethylene glycol, polypropylene glycol, and mixtures thereof. Preferably it may include any one selected from the group consisting of polyethylene glycol 200 to 600, glycerol, propylene glycol, ethylene glycol, polypropylene glycol and mixtures thereof. Preferably, as a liquid lubricant, petroleum oil, animal or vegetable oil, synthetic lubricating oil, or the like may be used, and most preferably, a liquid polyol may be used in view of stability of the composition and excellent usability. Alternatively, the lubricant is not limited to the liquid polyol, but may be present in the solid phase at room temperature due to the internal tensile force of the polymer at a predetermined molecular weight such as polyethylene glycol and polypropylene glycol having a polymer form, but by controlling the manufacturing temperature. It also includes high molecular weight polyols that can be liquefied and commercialized and maintained in a stable state.
본 발명의 조성물에는 소비자의 기호에 맞도록 착향제와 감미제를 첨가할 수 있다. 착향제는 구강에 잔류하며 지속적으로 향을 발산함으로써 상쾌감을 지속할 수 있도록 한다. Flavoring agents and sweetening agents can be added to the composition of the present invention to suit consumer preferences. Flavoring agents remain in the oral cavity and continually exude fragrance to help maintain freshness.
착향제로는 페퍼민트, 스피어민트 등의 민트, 윈터그린, 메틸 살리실레이트, 유게놀, 메론, 딸기, 오렌지, 바닐린 등이 사용될 수 있다. 일반적으로 착향제는 조성물 총 중량 대비 0.001 내지 10 중량% 범위에서 사용될 수 있다.As the flavoring agent, mint such as peppermint and spearmint, wintergreen, methyl salicylate, eugenol, melon, strawberry, orange, vanillin and the like can be used. Generally, flavoring agents can be used in the range of 0.001 to 10% by weight relative to the total weight of the composition.
또한, 본 발명의 조성물에는 제형이 가질 수 있는 기본적인 맛을 극복하기 위하여 감미제를 첨가할 수 있다. 감미제는 구강내 잔류하면서 지속적으로 맛을 제공해줌으로써 타액의 발생을 지속시켜주는 역할을 할 수 있다.In addition, sweeteners may be added to the compositions of the present invention to overcome the basic taste the formulation may have. Sweeteners can play a role in sustaining the development of saliva by providing a lasting taste while remaining in the mouth.
감미제로는 사카린, 수크랄로스, 설탕, 자일리톨, 솔비톨, 락토스, 만니톨, 말티톨, 에리쓰리톨, 아스파탐, 타우린, 사카린염, D-트립토판 등을 1 종 혹은 2 종 이상 혼합하여 사용할 수 있다. 사카린염 중에서는 사카린나트륨이 가장 널리 사용된다. 감미제의 양은 조성물 총 중량의 0.001 내지 20 중량% 범위에서 사용하는 것이 일반적이다. As the sweetener, one or two or more kinds of saccharin, sucralose, sugar, xylitol, sorbitol, lactose, mannitol, maltitol, erythritol, aspartame, taurine, saccharin salt and D-tryptophan may be used. Among saccharin salts, saccharin sodium is the most widely used. The amount of sweetener is generally used in the range of 0.001 to 20% by weight of the total weight of the composition.
약효제는 구강위생을 위하여 사용되는 약효제로는 충치 예방, 잇몸질환 예방, 치석 침착 예방, 미백 등의 효과가 있는 성분들을 사용할 수 있다. 충치 예방을 목적으로 사용하는 약효제에는 불소 이온을 포함한 미국 식품의약품 안전청에서 안전한 물질로 인정한 화합물이 포함된다. 불소 이온의 공급원으로 사용할 수 있는 화합물은 불화나트륨, 일불소인산나트륨, 불화주석, 불화암민을 들 수 있다. 불소의 함량은 국가에 따라 사용량의 차이가 있을 수 있지만, 바람직하게는 850 내지 1500 ppm 범위의 불소 이온 농도를 갖도록 이들 공급원의 1 종 또는 2 종 이상의 혼합물을 사용하는 것이 일반적이다. 재석회화제 역시 충치 예방제로 작용할 수 있다. 재석회화는 치아의 주요 구성 성분인 하이드록시아파타이트를 재생하고 복원시키는 역할을 하는 것이다. 하이드록시아파타이트의 주성분은 2가의 칼슘 양이온과 인산 음이온으로 구성된다. 따라서, 칼슘이온과 인산이온을 동시에 공급하거나 구강 내의 화학평형을 하이드록시아파타이트가 생성되는 쪽으로 이동시킬 수 있도록 칼슘 2가 이온이나 인산 음이온 1 종 이상이 함유된 것이면 재석회화제로 될 수 있다. 칼슘과 인을 제공하는 물질은 원료상의 하이드록시아파타이트, 제2인산칼슘, 염화칼슘, 카제인 포스펩티드, 칼슘 글리세로포스페이트, 제1인산나트륨, 제2인산나트륨, 제3인산나트륨, 제1인산칼륨, 제2인산칼륨, 제3인산칼륨 등이 이에 포함된다. 일반적으로 재석회화제는 조성물 전체의 0.001 내지 20 중량% 범위에서 사용하는 것이 바람직하다. 0.001 중량% 미만에서는 재석회화 효과가 떨어지게 되고, 20 중량% 보다 많으면 제제가 본래 갖고 있는 성질을 잃게 된다. 구강 위생용품을 사용하는 목적 중 하나는 구강 내에 생존하고 있는 구강내 유해 미생물에 대한 살균 또는 항염 작용을 통하여 진행되고 있는 잇몸질환의 완화뿐만 아니라 잇몸질환을 미리 방지하고자 하는 것이다. 이러한 목적을 위해서는 항균제로 알려진 이소프로필메틸페놀, 사이클로헥시딘, 세틸피리디늄 클로라이드, 잔토리졸 등이 사용될 수 있으며, 항염 작용을 위하여 비타민류와 효소, 아미노카프로산, 알라토인 및 그 유도체 등도 사용될 수 있다. 약효제는 0.005 중량 % 내지 5 중량%를 함유할 수 있다. 약효제 함량이 0.005 미만인 경우에는 약효를 나타내기 어려우며, 5 중량%를 초과 함유하는 경우에는 기본 베이스의 맛을 변화시키는 단점이 있다. 잇몸 질환 이외에도 미백 효과를 나타내는 과산화수소, 카바마이드 퍼옥사이드, 칼슘 퍼옥사이드 등이 사용될 수 있으며, 치석 침착 억제 효과를 얻기 위하여 피로인산나트륨, 산성 피로인산나트륨, 피로인산칼륨, 메타인산나트륨 등도 사용된다. 일반적으로 이들 약효제는 조성물 전체 중량의 0.001 내지 10 중량% 범위에서 사용한다. Pharmacological agents can be used as a pharmacological agent used for oral hygiene, such as caries prevention, gum disease prevention, tartar deposition prevention, whitening effect. Drugs used to prevent tooth decay include compounds recognized as safe by the US Food and Drug Administration, including fluoride ions. Examples of the compound that can be used as a source of fluorine ions include sodium fluoride, sodium monofluorophosphate, tin fluoride, and ammonium fluoride. The amount of fluorine may vary depending on the country, but it is common to use one kind or a mixture of two or more of these sources, preferably to have a fluorine ion concentration in the range of 850 to 1500 ppm. Remineralizing agents can also act as a caries preventer. Remineralization plays a role in regenerating and restoring hydroxyapatite, a major component of teeth. The main component of hydroxyapatite consists of divalent calcium cations and phosphate anions. Therefore, it can be a remineralizing agent if it contains at least one of calcium divalent ions or phosphate anions so as to simultaneously supply calcium ions and phosphate ions or to shift chemical equilibrium in the oral cavity toward the formation of hydroxyapatite. Substances that provide calcium and phosphorus include hydroxyapatite, dicalcium phosphate, calcium chloride, casein phosphate, calcium glycerophosphate, sodium monophosphate, dibasic sodium phosphate, sodium triphosphate, potassium phosphate, This includes potassium diphosphate, potassium triphosphate, and the like. In general, the remineralizing agent is preferably used in the range of 0.001 to 20% by weight of the entire composition. If it is less than 0.001% by weight, the effect of remineralization is inferior, and if it is more than 20% by weight, the property of the formulation is lost. One of the objectives of using oral hygiene products is to prevent gum disease as well as to alleviate gum disease that is progressing through antiseptic or anti-inflammatory action against harmful microorganisms in the oral cavity that survive in the oral cavity. For this purpose, isopropylmethylphenol, cyclohexidine, cetylpyridinium chloride, xantholizol, etc., which are known as antimicrobial agents, may be used, and vitamins and enzymes, aminocaproic acid, allatoin and derivatives thereof may also be used for anti-inflammatory action. Can be used. The agonist may contain 0.005% to 5% by weight. If the drug content is less than 0.005 it is difficult to show the drug, when containing more than 5% by weight has the disadvantage of changing the taste of the base base. In addition to gum disease, hydrogen peroxide, carbamide peroxide, calcium peroxide, and the like, which may have a whitening effect, may be used, and sodium pyrophosphate, acid pyrophosphate, potassium pyrophosphate, sodium metaphosphate, etc. may also be used to obtain tartar deposition inhibitory effect. Generally these agents are used in the range of 0.001 to 10% by weight of the total weight of the composition.
pH조정제로는 인산, 인산나트륨, 구연산, 구연산나트륨, 호박산, 호박산나트륨, 주석산, 주석산 나트륨 등을 사용할 수 있고, 구강용 조성물의 산성도는 일반적으로 5 내지 8이다. As the pH adjuster, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium stannate and the like can be used, the acidity of the composition for oral cavity is generally 5 to 8.
방부제로서는 안식향산, 메틸파라벤, 프로필파라벤, 안식향산나트륨 등을 사 용할 수 있다. Benzoic acid, methylparaben, propylparaben, sodium benzoate, etc. can be used as a preservative.
기포제로는 알킬황산나트륨, 라우릴 황산나트륨, 알킬살루코시네이트, 라우릴살루코시네이트, 코코일 글루타메이트 나트륨염, 미리스리토일 글루나메이트 나트륨염, 코카미도프로필베타인, 자당지방산에스테르, 소르비탄지방산에스테르, 폴리엑시에틸렌폴리옥시프로필렌의 공중합체(폴록사머) 등의 음이온, 양쪽성 및 비이온 계면 활성제를 단독 또는 2종 이상을 혼합하여 사용할 수 있다.Examples of the foaming agent include sodium alkyl sulfate, sodium lauryl sulfate, alkyl salucinate, lauryl salucinate, cocoyl glutamate sodium salt, myrithroyl glutamate sodium salt, cocamidopropyl betaine, sucrose fatty acid ester, and sorbitan fatty acid ester. And anionic, amphoteric, and nonionic surfactants such as copolymers of polyoxyethylene polyoxypropylene (poloxamer) can be used alone or in combination of two or more thereof.
증백제로는 산화티탄을 사용하며 일반적으로 0.1% 내지 2 중량% 사용한다.Titanium oxide is used as the brightener, and generally 0.1% to 2% by weight.
본 발명의 치약 조성물을 제조하는 방법은 업계에서 통상적으로 제조하는 방법에 따라 제조될 수 있다. The method for preparing the dentifrice composition of the present invention may be prepared according to a method commonly prepared in the art.
본 발명에 치약 조성물은 구강청정제, 의치세정제 등으로 전용될 수 있다. Toothpaste composition in the present invention can be used as a mouthwash, denture cleaner and the like.
본 발명에 따른 펌프형 치약 조성물은 펌프형 용기에 담지되어 제공된다. The pump toothpaste composition according to the present invention is provided supported on a pump type container.
본 발명은 상술한 펌프형 치약 조성물, 및 상기 펌프형 치약 조성물이 담지되는 펌프형 용기를 포함하는 펌프형 치약을 제공한다. The present invention provides a pump-type toothpaste comprising the pump-type toothpaste composition and the pump-type container on which the pump-type toothpaste composition is supported.
본 발명에 따르면, 펌프형 용기에 담지해 제공 가능한 펌프형 치약 조성물을 제공하며, 특히 펌프형 치약 조성물로서, 칫솔에 토출된 치약 조성물이 칫솔 속으로 스며들어 치아에 대한 발림성이 개선되고, 궁극적으로는 구강 내에서 오랫동안 지속적으로 약효성분 전달이 가능한 효과가 있다. According to the present invention, there is provided a pump-type toothpaste composition that can be supported and provided in a pump-type container, and in particular, as a pump-type toothpaste composition, the toothpaste composition discharged to the toothbrush penetrates into the toothbrush, improving the applicability to the teeth, and ultimately The effect is that the drug can be delivered continuously for a long time in the oral cavity.
본 명세서에 첨부되는 다음의 도면들은 본 발명의 바람직한 실시예를 예시하는 것이며, 전술한 발명의 내용과 함께 본 발명의 기술사상을 더욱 이해시키는 역할을 하는 것이므로, 본 발명은 그러한 도면에 기재된 사항에만 한정되어 해석되어서는 아니 된다.
도 1은 실시예 2에 따라 제조된 펌프형 치약 조성물(실시예 7, 실시예 8, 및 비교예 1)의 기포 만족도와 기포 질감 만족도를 평가한 값을 그래프로 도시한 것이다. The following drawings, which are attached to this specification, illustrate preferred embodiments of the present invention, and together with the contents of the present invention serve to further understand the technical spirit of the present invention, the present invention is limited to the matters described in such drawings. It should not be construed as limited.
1 is a graph showing values for evaluating bubble satisfaction and bubble texture satisfaction of a pump-type toothpaste composition (Example 7, Example 8, and Comparative Example 1) prepared according to Example 2. FIG.
이하, 본 발명을 보다 구체적으로 설명하기 위하여 하기 실시예 등을 들어 설명한다. 그러나, 본 발명에 따른 실시예들은 여러 가지 다른 형태로 변형될 수 있으며 본 발명의 범위가 아래에서 상술하는 실시예들에 한정되는 것으로 해석되어서는 안 된다. 본 발명의 실시예들은 본 발명의 구체적 이해를 돕기 위해 예시적으로 제공되는 것이다.Hereinafter, the following examples and the like will be described in order to describe the present invention in more detail. However, embodiments according to the present invention can be modified in many different forms and the scope of the present invention should not be construed as being limited to the embodiments described below. Embodiments of the present invention are provided by way of example in order to facilitate a specific understanding of the present invention.
실시예Example 1. 펌프형 치약 조성물의 제조 (1) 1. Preparation of Pump Type Toothpaste Composition (1)
실시예 및 비교예의 치약 조성물은 하기 표 1에 나타낸 성분 및 조성비로 제조하였다. 정제수, 액상폴리올, 향료, 약효제, 계면활성제, 결합제, 사카린, 계면활성제 등 분말 성분을 완전히 분산시켜 1 차 혼합하고, 그 다음에 실리카 등의 연마제와 약효제를 투입하고 진공 상태 하에서 혼합하여 치약 조성물을 제조하였다.Toothpaste compositions of Examples and Comparative Examples were prepared with the components and composition ratios shown in Table 1 below. Powder components such as purified water, liquid polyol, flavoring agent, pharmacological agent, surfactant, binder, saccharin, and surfactant are completely dispersed and mixed firstly. Then, abrasives such as silica and medicament are added and mixed under vacuum. The composition was prepared.
실험예Experimental Example 1-1. 제조 치약의 점도 ( 1-1. Viscosity of manufactured toothpaste ( 부룩필드점도계를Brookfield Viscometer 이용한 점도 측정) Viscosity measurement)
상기 표 1의 실시예 1 내지 5와 비교예 1과 같이 제조한 치약에 대하여, 상온(25℃)에서 점도를 측정하기 위하여, 브룩필드점도계 RVT형으로 스핀들 7번을 이용하여 분당 20회전의 회전속도로 회전하면서 점도 값을 측정하였으며, 그 결과는 하기 표 2와 같았다. For toothpastes prepared in Examples 1 to 5 and Comparative Example 1 of Table 1, in order to measure the viscosity at room temperature (25 ° C), Brookfield Viscometer RVT type was rotated 20 revolutions per minute using spindle 7 The viscosity value was measured while rotating at a speed, and the results are shown in Table 2 below.
비교예 1은 고점도를 나타내는 반면에, 실시예 1 내지 5의 경우 5,500 내지 4만 cP의 범위 내의 점도를 나타냈다. Comparative Example 1 exhibited high viscosity, while Examples 1 to 5 exhibited a viscosity within the range of 5,500 to 40,000 cP.
실험예Experimental Example 1-2. 칫솔모에 스며드는 정도 1-2. Soaking in the brush head
상기 표 1의 실시예 1 내지 5와 비교예 1과 같이 제조한 치약을, 실시예 1 내지 5의 젤상의 치약 조성물은 펌프형 용기에 담고 비교예 1의 페이스트상의 치약 조성물은 튜브에 담아, 홀간격(칫솔모와 칫솔모 사이의 간격) 1.5mm인 칫솔에 토출하여, 칫솔모에 치약을 안착하고 10초 이후에 칫솔모의 상단에서 하단으로 치약이 전개하는 침투 깊이를 측정하였으며, 그 결과는 하기 표 3과 같았다. The toothpaste composition prepared in Examples 1 to 5 and Comparative Example 1 of Table 1, the gel toothpaste composition of Examples 1 to 5 was put in a pump-type container, the paste toothpaste composition of Comparative Example 1 was put in a tube, a hole Discharged to a toothbrush of 1.5mm intervals (gap between bristles and bristles), the toothpaste was settled on the bristles, and after 10 seconds, the penetration depth of the toothpaste developed from the top of the bristles to the bottom was measured. It was like
비교예 1에 따른 페이스트 치약은 칫솔모에 스며들지 않는데 반해, 실시예 1 내지 5의 경우 칫솔 간극 사이로 1 - 2 mm 깊이로 칫솔모에 스며든 것을 알 수 있었다. The paste toothpaste according to Comparative Example 1 did not penetrate the bristles, whereas in Examples 1 to 5, it was found that the toothbrush penetrated the bristles at a depth of 1-2 mm between the toothbrush gaps.
또한, 상기 표 1의 실시예 1 내지 5와 비교예 1과 같이 제조한 치약을, 실시예 1 내지 5의 젤상의 치약 조성물은 펌프형 용기에 담고 비교예 1의 페이스트상의 치약 조성물은 튜브에 담아, 홀간격(칫솔모와 칫솔모 사이의 간격)이 2mm인 칫솔에 토출하여, 칫솔모에 치약을 안착하고 10초 이후에 침투 깊이를 측정하였으며, 그 결과는 하기 표 4와 같았다. In addition, the toothpaste composition prepared in Examples 1 to 5 and Comparative Example 1 of Table 1, the gel toothpaste composition of Examples 1 to 5 was put in a pump-type container, the paste toothpaste composition of Comparative Example 1 was put in a tube , Hole spacing (gap between the bristles and bristles) was discharged to the toothbrush 2mm, the toothpaste was placed on the bristles and the penetration depth was measured after 10 seconds, the results were as shown in Table 4.
비교예 1에 따른 페이스트 치약은 칫솔모에 스며들지 않는데 반해, 실시예 1 내지 5의 경우 칫솔 간극 사이로 1.5 - 5 mm 깊이로 칫솔모에 스며든 것을 알 수 있었다. The paste toothpaste according to Comparative Example 1 did not penetrate the bristles, whereas in Examples 1 to 5, it was found that the toothpaste penetrated to the bristles at a depth of 1.5-5 mm between the toothbrush gaps.
상기 표 3 및 표 4의 결과를 통해 알 수 있는 바와 같이, 홀간격이 큰 칫솔을 사용할수록, 비교예과 실시예 간의 칫솔모 스며듦의 차이가 현격히 나타냈다. As can be seen from the results of Table 3 and Table 4, the more the use of the toothbrush with a large hole spacing, the difference in bristles infiltrating between the comparative example and the embodiment was markedly.
상기 표 3 및 표 4의 결과를 통해 알 수 있는 바와 같이, 비교예 1에 비해 실시예 1 - 5에 따른 치약은 펌프형 용기에 담지해 칫솔에 토출하면 칫솔모에 잘 스며들고, 따라서 칫솔질을 하는 동안 지속적으로 구강 내에 약효성분을 전달하는 효과가 있음을 알 수 있었다. As can be seen through the results of Table 3 and Table 4, compared to Comparative Example 1, the toothpaste according to Examples 1 to 5 is impregnated to the bristles when soaked in the pump-type container and discharged in the toothbrush, thus brushing It was found that the effect of delivering the active ingredient in the oral cavity continuously.
실시예Example 2. 펌프형 치약 조성물의 제조 (2) 2. Preparation of Pump Type Toothpaste Composition (2)
실시예 및 비교예의 치약 조성물은 하기 표 5에 나타낸 성분 및 조성비로 제조하였다. 정제수, 액상폴리올, 향료, 약효제, 계면활성제, 결합제, 사카린, 계면활성제 등 분말 성분을 완전히 분산시켜 1 차 혼합하고, 그 다음에 실리카 등의 연마제와 약효제를 투입하고 진공 상태 하에서 혼합하여 치약 조성물을 제조하였다.Toothpaste compositions of Examples and Comparative Examples were prepared with the components and composition ratios shown in Table 5. Powder components such as purified water, liquid polyol, flavoring agent, pharmacological agent, surfactant, binder, saccharin, and surfactant are completely dispersed and mixed firstly. Then, abrasives such as silica and medicament are added and mixed under vacuum. The composition was prepared.
실험예Experimental Example 2-1. 제조 치약의 점도 ( 2-1. Viscosity of manufactured toothpaste ( 부룩필드점도계를Brookfield Viscometer 이용한 점도 측정) Viscosity measurement)
상기 표 5의 실시예 1 내지 24와 비교예 1 내지 4과 같이 제조한 치약에 대하여 상온(25℃)에서 점도를 측정하기 위하여, 브룩필드점도계 RVT형으로 스핀들 7번을 이용하여 분당 20회전의 회전속도로 회전하면서 점도 값을 측정하였으며, 그 결과는 하기 표 6과 같았다. In order to measure the viscosity at room temperature (25 ° C) with respect to the toothpaste prepared in Examples 1 to 24 and Comparative Examples 1 to 4 of Table 5, Brookfield viscometer RVT type of 20 revolutions per minute using spindle 7 The viscosity value was measured while rotating at the rotational speed, and the results are shown in Table 6 below.
비교예 1 내지 4 및 실시예 1 내지 24, 모두 4만 cP이하 범위 내의 점도를 나타냈다. In Comparative Examples 1 to 4 and Examples 1 to 24, both exhibited viscosities within the range of 40,000 cP or less.
실험예Experimental Example 2-2. 칫솔모에 스며드는 정도 2-2. Soaking in the brush head
상기 표 5의 실시예 1 내지 24와 비교예 1 내지 4과 같이 제조한 치약을 펌프형 용기에 담아 홀간격(칫솔모와 칫솔모 사이의 간격) 1 ~ 1.5mm인 칫솔에 토출하여, 칫솔모에 치약을 안착하고 10초 이후에 칫솔모의 상단에서 하단으로 치약이 전개하는 침투 깊이를 측정하였으며, 그 결과는 하기 표 7과 같았다. The toothpaste prepared in Examples 1 to 24 and Comparative Examples 1 to 4 of Table 5 was put in a pump-type container and discharged to a toothbrush having a hole spacing (gap between the bristles and bristles) of 1 to 1.5 mm, and the toothpaste to the bristles. After 10 seconds of seating, the penetration depth of the toothpaste was measured from the top to the bottom of the bristles, and the results were as shown in Table 7 below.
비교예 1-4에 따른 페이스트 치약은 적절한 점도를 나타내기는 하나, 침투깊이는 실시예 1 내지 24에 비해 현저히 떨어졌다. 이를 통해, 비교예 1 내지 4의 경우 탄성계수가 높은 것으로 예상되었다. Paste toothpaste according to Comparative Examples 1-4 showed an appropriate viscosity, but the penetration depth was significantly lower than that of Examples 1 to 24. Through this, in the case of Comparative Examples 1 to 4 was expected to have a high elastic modulus.
실험예Experimental Example 2-3. Tan δ (Loss modulus(G')/Elastic Modulus(G") 2-3. Tan δ (Loss modulus (G ') / Elastic Modulus (G ")
Paar Physica 유변학 측정기를 이용하여 진폭왕복 진동 시험(Amplitude sweep oscillation test)을 실시하였는바, Shear Stress(전단응력) 1 일 때 탄성계수와 점성계수를 읽고 이것에 대한 Tan δ 값을 구하였다. Amplitude sweep oscillation test was performed using a Paar Physica rheometer. Shear stress (1) was used to read the elastic and viscous coefficients and to determine the Tan δ values.
Tan δ의 값이 클수록, 점성 계수가 높은 고분자를 사용함으로써 치약의 점도가 올라간다 할지라도 흐름성을 가질 수 있는 구조를 만들어낸다는 것을 의미한다. 상기 표 8에 따르면, 실시예의 경우 비교예에 비해 Tan δ의 값이 크다는 것을 알 수 있다. The larger the value of Tan δ, the higher the viscosity of the polymer, the higher the viscosity of the toothpaste, even if the viscosity of the flow is possible to create a structure that can have. According to Table 8, in the case of the Example it can be seen that the value of Tan δ is larger than the comparative example.
실험예Experimental Example 2-4. 2-4. 풍만감Voluptuous 측정 Measure
실시예 7과 8과 비교예 1에 따른 치약을 평가집단에게 사용하게 한 후 양치시 풍만감의 평가 척도가 되는 속성에 대한 설문 평가를 진행하였다. 설문은 5점 척도로 진행하였으며 1점이 질감에 대한 만족이 낮은 것이며 5점이 높은 것으로 평가하였다. After the toothpaste according to Examples 7 and 8 and Comparative Example 1 was used by the evaluation group, a questionnaire evaluation was performed on the property of being an evaluation measure of voluminous feeling at the time of brushing teeth. The survey was conducted on a five-point scale, with one point indicating low satisfaction with the texture and five points high.
그 결과, 도 1에 도시된 바와 같이, 실시예를 사용한 경우 기포 질감 및 기포에 대한 만족도가 비교예에 비하여 높음을 확인하였다.As a result, as shown in Figure 1, when using the embodiment was confirmed that the satisfaction of the bubble texture and the bubble is higher than the comparative example.
Claims (8)
폴리비닐피롤리돈(PVP), 하이드록시프로필메틸셀룰로오스(HPMC), 및 하이드록시프로필셀룰로오스(HPC)로 이루어진 군에서 선택된 1 이상의 결합제를 필수적으로 포함하는 것을 특징으로 하는 펌프형 치약 조성물로서,
브룩필드점도계 RVT형으로 스핀들 7번을 이용하여 분당 20회전의 회전속도로 회전하면서 측정한 상기 조성물의 점도가 상온(25℃)에서 5 X 103 cP 이상 60 X 103 cP 미만이고, 전단응력(Shear Stress)이 1 일 때 Tan δ (Loss modulus(손실계수)(G")/Elastic Modulus(탄성계수)(G'))가 적어도 0.4인 것을 특징으로 하는 펌프형 치약 조성물. A pump type toothpaste composition supported on a pump type container,
A pump type toothpaste composition comprising essentially one or more binders selected from the group consisting of polyvinylpyrrolidone (PVP), hydroxypropylmethylcellulose (HPMC), and hydroxypropylcellulose (HPC),
Brookfield viscometer RVT type, the viscosity of the composition measured while rotating at a rotational speed of 20 revolutions per minute using a spindle number 7 at room temperature (25 ℃) is more than 5 X 10 3 cP less than 60 X 10 3 cP, shear stress A pump type toothpaste composition, characterized in that Tan δ (Loss modulus (G ″) / Elastic Modulus (G ′)) is at least 0.4 when (Shear Stress) is 1.
Priority Applications (10)
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| KR1020170010589A KR102060426B1 (en) | 2017-01-23 | 2017-01-23 | Pumping type toothpaste composition |
| PCT/KR2018/000410 WO2018135791A1 (en) | 2017-01-23 | 2018-01-09 | Pump-type toothpaste composition |
| AU2018210626A AU2018210626B2 (en) | 2017-01-23 | 2018-01-10 | Pump-type toothpaste composition |
| EP18741570.8A EP3572067A4 (en) | 2017-01-23 | 2018-01-10 | Pump-type toothpaste composition |
| CN201880006835.4A CN110167526B (en) | 2017-01-23 | 2018-01-10 | Pump-pressed toothpaste composition |
| PCT/KR2018/000485 WO2018135797A1 (en) | 2017-01-23 | 2018-01-10 | Pump-type toothpaste composition |
| RU2019126290A RU2778519C2 (en) | 2017-01-23 | 2018-01-10 | Composition of pump-type toothpaste |
| JP2019538652A JP7118978B2 (en) | 2017-01-23 | 2018-01-10 | Pump type dentifrice composition |
| US16/479,080 US10842722B2 (en) | 2017-01-23 | 2018-01-10 | Pump-type toothpaste composition |
| US17/075,135 US20210030644A1 (en) | 2017-01-23 | 2020-10-20 | Pump-Type Toothpaste Composition |
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| JP2001031542A (en) | 1999-07-21 | 2001-02-06 | Nippon Zettoc Co Ltd | Composition for oral cavity |
| US20120020897A1 (en) * | 2009-04-02 | 2012-01-26 | Colgate-Palmolive Company | Dentifrice composition |
| JP2013523729A (en) | 2010-03-31 | 2013-06-17 | コルゲート・パーモリブ・カンパニー | Oral care composition |
| US20150238395A1 (en) * | 2012-10-19 | 2015-08-27 | Colgate-Palmolive Company | Toothpaste Composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001031542A (en) | 1999-07-21 | 2001-02-06 | Nippon Zettoc Co Ltd | Composition for oral cavity |
| US20120020897A1 (en) * | 2009-04-02 | 2012-01-26 | Colgate-Palmolive Company | Dentifrice composition |
| JP2013523729A (en) | 2010-03-31 | 2013-06-17 | コルゲート・パーモリブ・カンパニー | Oral care composition |
| US20150238395A1 (en) * | 2012-10-19 | 2015-08-27 | Colgate-Palmolive Company | Toothpaste Composition |
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